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Depolarizing Science: The Effects Of Local Crises On Partisan Science Policy, Christopher R. Handy Apr 2016

Depolarizing Science: The Effects Of Local Crises On Partisan Science Policy, Christopher R. Handy

Honors Capstones

No abstract provided.

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Competition-Mediated Feedbacks In Experimental Multispecies Epizootics, Tad Dallas, Richard J. Hall, John M. Drake Mar 2016

Competition-Mediated Feedbacks In Experimental Multispecies Epizootics, Tad Dallas, Richard J. Hall, John M. Drake

Faculty Publications

© 2016 by the Ecological Society of America. Competition structures ecological communities and alters host-pathogen interactions. In environmentally transmitted pathogens, an infection-resistant competitor may influence infection dynamics in a susceptible species through the negative impacts of competition (e.g., by reducing host density or causing nutritional stress that increases susceptibility to infection) and/or the positive impacts of reducing transmission efficiency (e.g., by removing environmental pathogen stages). Thus, a non-susceptible competitor may enhance, reduce, or have no net effect on susceptible host density and infection prevalence. Here, we couple an epidemiological model with experimental epidemics to test how resource competition with a …

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Costs Of Resistance And Infection By A Generalist Pathogen, Tad Dallas, Mathieu Holtackers, John M. Drake Mar 2016

Costs Of Resistance And Infection By A Generalist Pathogen, Tad Dallas, Mathieu Holtackers, John M. Drake

Faculty Publications

© 2016 Published by John Wiley & Sons Ltd. Pathogen infection is typically costly to hosts, resulting in reduced fitness. However, pathogen exposure may also come at a cost even if the host does not become infected. These fitness reductions, referred to as "resistance costs", are inducible physiological costs expressed as a result of a trade-off between resistance to a pathogen and aspects of host fitness (e.g., reproduction). Here, we examine resistance and infection costs of a generalist fungal pathogen (Metschnikowia bicuspidata) capable of infecting a number of host species. Costs were quantified as reductions in host lifespan, total reproduction, …

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Halobacteriovorax, An Underestimated Predator On Bacteria: Potential Impact Relative To Viruses On Bacterial Mortality, Henry N. Williams, Despoina S. Lymperopoulou, Rana Athar, Ashvini Chauhan, Tamar L. Dickerson, Huan Chen, Edward Laws, Timkhite Kulu Berhane, Adrienne R. Flowers, Nadine Bradley, Shanterial Young, Denene Blackwood, Jacqueline Murray, Oladipupo Mustapha, Cory Blackwell, Yahsuan Tung, Rachel T. Noble Feb 2016

Halobacteriovorax, An Underestimated Predator On Bacteria: Potential Impact Relative To Viruses On Bacterial Mortality, Henry N. Williams, Despoina S. Lymperopoulou, Rana Athar, Ashvini Chauhan, Tamar L. Dickerson, Huan Chen, Edward Laws, Timkhite Kulu Berhane, Adrienne R. Flowers, Nadine Bradley, Shanterial Young, Denene Blackwood, Jacqueline Murray, Oladipupo Mustapha, Cory Blackwell, Yahsuan Tung, Rachel T. Noble

Faculty Publications

Predation on bacteria and accompanying mortality are important mechanisms in controlling bacterial populations and recycling of nutrients through the microbial loop. The agents most investigated and seen as responsible for bacterial mortality are viruses and protists. However, a body of evidence suggests that predatory bacteria such as the Halobacteriovorax (formerly Bacteriovorax), a Bdellovibrio-like organism, contribute substantially to bacterial death. Until now, conclusive evidence has been lacking. The goal of this study was to better understand the contributors to bacterial mortality by addressing the poorly understood role of Halobacteriovorax and how their role compares with that of viruses. The results revealed …

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Clean And White: A History Of Environmental Racism In The United States, Andrew Kahrl Jan 2016

Clean And White: A History Of Environmental Racism In The United States, Andrew Kahrl

Civil War Book Review

A Long View of Environmental Racism in the United States From the nation's founding in the eighteenth century to the present, white stereotypes of black bodies as dirty and diseased have formed the ideological basis for all manner of racist policies and practices -- from jobs to housing to public a....

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Deletion Of A Predicted Β-Sheet Domain Within The Amino Terminus Of Herpes Simplex Virus Glycoprotein K Conserved Among Alphaherpesviruses Prevents Virus Entry Into Neuronal Axons, Nithya Jambunathan, Anu Susan Charles, Ramesh Subramanian, Ahmad A. Saied, Misagh Naderi, Paul Rider, Michal Brylinski, Vladimir N. Chouljenko, Konstantin G. Kousoulas Jan 2016

Deletion Of A Predicted Β-Sheet Domain Within The Amino Terminus Of Herpes Simplex Virus Glycoprotein K Conserved Among Alphaherpesviruses Prevents Virus Entry Into Neuronal Axons, Nithya Jambunathan, Anu Susan Charles, Ramesh Subramanian, Ahmad A. Saied, Misagh Naderi, Paul Rider, Michal Brylinski, Vladimir N. Chouljenko, Konstantin G. Kousoulas

Faculty Publications

© 2016, American Society for Microbiology. We have shown previously that herpes simplex virus 1 (HSV-1) lacking expression of the entire glycoprotein K (gK) or expressing gK with a 38-amino-acid deletion (gKΔ31-68 mutation) failed to infect ganglionic neurons after ocular infection of mice. We constructed a new model for the predicted three-dimensional structure of gK, revealing that the gKΔ31-68 mutation spans a well-defined β-sheet structure within the amino terminus of gK, which is conserved among alphaherpesviruses. The HSV- 1(McKrae) gKΔ31-68 virus was tested for the ability to enter into ganglionic neuronal axons in cell culture of explanted rat ganglia using …

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Deletion Of A Predicted Β-Sheet Domain Within The Amino Terminus Of Herpes Simplex Virus Glycoprotein K Conserved Among Alphaherpesviruses Prevents Virus Entry Into Neuronal Axons, Nithya Jambunathan, Anu Susan Charles, Ramesh Subramanian, Ahmad A. Saied, Misagh Naderi, Paul Rider, Michal Brylinski, Vladimir N. Chouljenko, Konstantin G. Kousoulas Jan 2016

Deletion Of A Predicted Β-Sheet Domain Within The Amino Terminus Of Herpes Simplex Virus Glycoprotein K Conserved Among Alphaherpesviruses Prevents Virus Entry Into Neuronal Axons, Nithya Jambunathan, Anu Susan Charles, Ramesh Subramanian, Ahmad A. Saied, Misagh Naderi, Paul Rider, Michal Brylinski, Vladimir N. Chouljenko, Konstantin G. Kousoulas

Faculty Publications

© 2016, American Society for Microbiology. We have shown previously that herpes simplex virus 1 (HSV-1) lacking expression of the entire glycoprotein K (gK) or expressing gK with a 38-amino-acid deletion (gKΔ31-68 mutation) failed to infect ganglionic neurons after ocular infection of mice. We constructed a new model for the predicted three-dimensional structure of gK, revealing that the gKΔ31-68 mutation spans a well-defined β-sheet structure within the amino terminus of gK, which is conserved among alphaherpesviruses. The HSV- 1(McKrae) gKΔ31-68 virus was tested for the ability to enter into ganglionic neuronal axons in cell culture of explanted rat ganglia using …

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The Evaluation Of Eprinomectin (Longrange®) On Long-Term Parasitic Infection In Nursing Calves During Summer Grazing®, Lyndsea D. Seibert Jan 2016

The Evaluation Of Eprinomectin (Longrange®) On Long-Term Parasitic Infection In Nursing Calves During Summer Grazing®, Lyndsea D. Seibert

LSU Master's Theses

One of the most significant threats to the well-being and performance of grazing livestock are gastrointestinal nematode (GIN) parasitic infections. Allowing a large GIN burden to manifest can cause a significant cost in terms of productivity in grazing cattle. Beef producers commonly rely greatly on the efficacy of broad-spectrum anthelmintics, to not only kill resident worms but to also prevent the establishment of ingested infective stage larvae (L3) for a period following treatment. Eprinomectin (LONGRANGE®, E-LR) is the first extended-release injectable cattle dewormer that claims to provide cattle producers season-long persistent parasite control for 100 to 150 d in a …

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Roles Of Members Of The Conserved Deda/Tvp38 Membrane Protein Family In Escherichia Coli Drug Resistance And Alkaline Ph Tolerance, Sujeet Kumar Jan 2016

Roles Of Members Of The Conserved Deda/Tvp38 Membrane Protein Family In Escherichia Coli Drug Resistance And Alkaline Ph Tolerance, Sujeet Kumar

LSU Doctoral Dissertations

The objective of this dissertation is to understand the functions of Escherichia coli YqjA and YghB, which are members of the conserved DedA/Tvp38 membrane protein family. YqjA and YghB are inner membrane (IM) proteins with multiple predicted membrane–spanning domain, sharing 62% amino acid identity and partly overlapping functions. Simultaneous in-frame deletions of these two genes in a strain named BC202 results in various phenotypes including cell division defects, temperature sensitivity, and sensitivity to drugs and alkaline pH. The cell division defect of BC202 is due to the inefficient secretion of periplasmic amidases by the twin arginine transport (Tat) pathway into …

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Human Norovirus In Artificial And Environmental Marine Water: Development Of Antibody Based Rapid Methods, Morgan Maite Jan 2016

Human Norovirus In Artificial And Environmental Marine Water: Development Of Antibody Based Rapid Methods, Morgan Maite

LSU Doctoral Dissertations

Norovirus (NoV) is the principal cause of viral gastroenteritis in the United States. It has been linked to filter-feeding molluscan shellfish, that bioaccumulate the virus from contaminated surrounding waters. The consumption of raw or undercooked contaminated oysters may result in acute gastroenteritis. We investigated the occurrence of NoV GI and GII and microbial indicators of fecal contamination in oysters and harvesting water from areas along the Louisiana Gulf Coast. We developed a filtration and concentration method for the detection of NoV from oyster harvesting waters. Lastly, this body of work compares commonly used molecular techniques (RT-PCR) and a commercial enzyme …

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Isolation And Identification Of Foodborne Pathogens And Spoilage Bacteria In Environmental And Food Samples, Myriam Evelyn Gutierrez Barberena Jan 2016

Isolation And Identification Of Foodborne Pathogens And Spoilage Bacteria In Environmental And Food Samples, Myriam Evelyn Gutierrez Barberena

LSU Doctoral Dissertations

Escherichia coli O157:H7 has become an important problem for human health in the United States. Scientific studies indicate cattle herds as primary reservoirs of E. coli O157:H7. To diagnose this pathogen, proper isolation and identification methods are crucial. From five different culture media, CT-SMAC and CHROMagar™ O157 results analyzed simultaneously were the best option for an effective detection of environmental E. coli O157. Despite extensive research at feedlots and dairy farms, there is limited information available on the prevalence of E. coli O157:H7 at cow/calf operations. From 28 small-scale cow/calf operations in the state of Louisiana, we observed an 8% …

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Detection Of Antibiotic Resistance Clostridium Difficile In Lettuce, Yi Han Jan 2016

Detection Of Antibiotic Resistance Clostridium Difficile In Lettuce, Yi Han

LSU Master's Theses

Clostridium difficile (C. difficile) is regarded as the major cause of infectious diarrhea in humans after antimicrobial treatment. C. difficile has been reported to be widely isolated from food animals and meat. The main purpose of this study was to characterize C. difficile isolates from retail fresh vegetable (lettuce), test the antibiotic-resistance property using five common clinical-selected antibiotics (metronidazole, vancomycin, clindamycin, erythromycin, and cefotaxime). Lettuces (grown in California, Arkansas, and Louisiana) were purchased from retail stores. Toxigenic C. difficile was isolated from 13.8% (41/297) of the lettuce samples. Among the toxigenic isolates, 82.9% (34/41) only produce toxin B, and 17.1% …

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Effects Of Truck Based Ultra-Low Volume Mosquito Adulticides On Honey Bees (Apis Mellifera) In A Real World Scenario, Vivek Pokhrel Jan 2016

Effects Of Truck Based Ultra-Low Volume Mosquito Adulticides On Honey Bees (Apis Mellifera) In A Real World Scenario, Vivek Pokhrel

LSU Master's Theses

Honey bees are crucial pollinators for many economically important fruit crops. The recent honey bee colony decline in the United States and other regions of the world has caused concern among commercial beekeepers, research groups, the government, and the general public. The role of pesticides in recent honey bee declines has not been fully determined. In Louisiana, it is a common practice to spray truck based ultra-low volume mosquito adulticides in Integrated Mosquito Management Programs to control mosquitoes and minimize the risk of vector borne viruses such as West Nile, chikungunya, and Zika. This study measured the effects of truck …

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Chikungunya Virus Infection-Associated Bone And Joint Disease, Brad A. Goupil Jan 2016

Chikungunya Virus Infection-Associated Bone And Joint Disease, Brad A. Goupil

LSU Doctoral Dissertations

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that circulates predominantly in tropical and subtropical regions. Infection results in severe debilitating polyarthralgia during the acute phase of disease, and reports suggest that chronic arthralgia lasting months to years after the initial infection can occur. More severe and prolonged disease has been associated with pre-existing joint disease, though this has not been experimentally examined. In the research presented herein, two established mouse models (adult IRF 3/7 -/- -/- and wild-type C57BL/6J mice) were utilized to characterize CHIKV-associated bone and joint disease and evaluate its impact on the progression of pre-existing osteoarthritis (OA) …

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Immune Gene Variation And Susceptibility To Upper Respiratory Tract Disease In Gopher Tortoises, Jean Pierre Elbers Jan 2016

Immune Gene Variation And Susceptibility To Upper Respiratory Tract Disease In Gopher Tortoises, Jean Pierre Elbers

LSU Doctoral Dissertations

The immune system defends the host from bacteria, fungi, parasites, and viruses. The immune system is partially under genetic control through immune response genes, such as those of the major histocompatibility complex (MHC) whose nucleotide variation influences the host’s ability to recognize foreign pathogens and can influence disease susceptibility. Populations of threatened species generally possess low levels of genetic variation, and genetically depauperate hosts may be at greater risk of infectious disease contributing to extirpations because they also possess low immunogenetic variation. My dissertation examines the relationship between immunogenetic variation and disease susceptibility and the factors that influence innate immune …

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Using An External Exposome Framework To Examine Pregnancy-Related Morbidities And Mortalities: Implications For Health Disparities Research, Tonny J. Oyana, Patricia Matthews-Juarez, Stephania A. Cormier, Xiaoran Xu, Paul D. Juarez Dec 2015

Using An External Exposome Framework To Examine Pregnancy-Related Morbidities And Mortalities: Implications For Health Disparities Research, Tonny J. Oyana, Patricia Matthews-Juarez, Stephania A. Cormier, Xiaoran Xu, Paul D. Juarez

Faculty Publications

© 2015 by the authors; licensee MDPI, Basel, Switzerland. Objective: We have conducted a study to assess the role of environment on the burden of maternal morbidities and mortalities among women using an external exposome approach for the purpose of developing targeted public health interventions to decrease disparities. Methods: We identified counties in the 48 contiguous USA where observed low birthweight (LBW) rates were higher than expected during a five-year study period. The identification was conducted using a retrospective space-time analysis scan for statistically significant clusters with high or low rates by a Discrete Poisson Model. Results: We observed statistically …

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Association Of Car Ownership And Physical Activity Across The Spectrum Of Human Development: Modeling The Epidemiologic Transition Study (Mets), David A. Shoham, Lara R. Dugas, Pascal Bovet, Terrence E. Forrester, Estelle V. Lambert, Jacob Plange-Rhule, Dale A. Schoeller, Soren Brage, Ulf Ekelund, Ramon A. Durazo-Arvizu, Richard S. Cooper, Amy Luke Dec 2015

Association Of Car Ownership And Physical Activity Across The Spectrum Of Human Development: Modeling The Epidemiologic Transition Study (Mets), David A. Shoham, Lara R. Dugas, Pascal Bovet, Terrence E. Forrester, Estelle V. Lambert, Jacob Plange-Rhule, Dale A. Schoeller, Soren Brage, Ulf Ekelund, Ramon A. Durazo-Arvizu, Richard S. Cooper, Amy Luke

Faculty Publications

Background: Variations in physical activity (PA) across nations may be driven by socioeconomic position. As national incomes increase, car ownership becomes within reach of more individuals. This report characterizes associations between car ownership and PA in African-origin populations across 5 sites at different levels of economic development and with different transportation infrastructures: US, Seychelles, Jamaica, South Africa, and Ghana. Methods: Twenty-five hundred adults, ages 25-45, were enrolled in the study. A total of 2,101 subjects had valid accelerometer-based PA measures (reported as average daily duration of moderate to vigorous PA, MVPA) and complete socioeconomic information. Our primary exposure of interest …

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Detection Of Nucleic Acid Sequence Differences Using The Ligase Detection Reaction With Addressable Arrays, Francis Barany, George Barany, Robert P. Hammer, Maria Kempe, Herman Blok, Monib Zirvi Dec 2015

Detection Of Nucleic Acid Sequence Differences Using The Ligase Detection Reaction With Addressable Arrays, Francis Barany, George Barany, Robert P. Hammer, Maria Kempe, Herman Blok, Monib Zirvi

College of Science Patents

The present invention describes a method for identifying one or more of a plurality of sequences differing by one or more single base changes, insertions, deletions, or translocations in a plurality of target nucleotide sequences. The method includes a ligation phase, a capture phase, and a detection phase. The ligation phase utilizes a ligation detection reaction between one oligonucleotide probe, which has a target sequence-specific portion and an addressable array-specific portion, and a second oligonucleotide probe, having a target sequence-specific portion and a detectable label. After the ligation phase, the capture phase is carried out by hybridizing the ligated oligonucleotide …

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Mathematics Library News 14, Aaron Lercher Dec 2015

Mathematics Library News 14, Aaron Lercher

Faculty Publications

No abstract provided.

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Failure Of A Heterologous Recombinant Sca5/Ompb Protein-Based Vaccine To Elicit Effective Protective Immunity Against Rickettsia Rickettsii Infections In C3h/Hen Mice, Sean P. Riley, Marissa M. Cardwell, Yvonne G. Chan, Ludovic Pruneau, Fabio Del Piero, Juan J. Martinez Dec 2015

Failure Of A Heterologous Recombinant Sca5/Ompb Protein-Based Vaccine To Elicit Effective Protective Immunity Against Rickettsia Rickettsii Infections In C3h/Hen Mice, Sean P. Riley, Marissa M. Cardwell, Yvonne G. Chan, Ludovic Pruneau, Fabio Del Piero, Juan J. Martinez

Faculty Publications

Spotted fever group (SFG) rickettsial species are obligate intracellular tick-borne pathogens that are responsible for important human diseases. Previous reports have demonstrated the feasibility of using recombinant surface cell antigen Sca5/OmpB to elicit protective immunity against homologous challenges using murine models of Mediterranean spotted fever and Rocky Mountain spotted fever. In addition, the feasibility of generating cross-protective immunity against related rickettsial species has also been established, but the molecular basis for these phenomena was not explored. Here, we demonstrate that vaccination of C3H/HeN mice with a recombinant OmpB domain derived from Rickettsia conorii induced high titer humoral immune responses that …

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Ecological Networks In Stored Grain: Key Postharvest Nodes For Emerging Pests, Pathogens, And Mycotoxins, John F. Hernandez Nopsa, Gregory J. Daglish, David W. Hagstrum, John F. Leslie, Thomas W. Phillips, Caterina Scoglio, Sara Thomas-Sharma, Gimme H. Walter, Karen A. Garrett Sep 2015

Ecological Networks In Stored Grain: Key Postharvest Nodes For Emerging Pests, Pathogens, And Mycotoxins, John F. Hernandez Nopsa, Gregory J. Daglish, David W. Hagstrum, John F. Leslie, Thomas W. Phillips, Caterina Scoglio, Sara Thomas-Sharma, Gimme H. Walter, Karen A. Garrett

Faculty Publications

Wheat is at peak quality soon after harvest. Subsequently, diverse biota use wheat as a resource in storage, including insects and mycotoxin-producing fungi. Transportation networks for stored grain are crucial to food security and provide a model system for an analysis of the population structure, evolution, and dispersal of biota in networks. We evaluated the structure of rail networks for grain transport in the United States and Eastern Australia to identify the shortest paths for the anthropogenic dispersal of pests and mycotoxins, as well as the major sources, sinks, and bridges for movement. We found important differences in the risk …

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Evidence For The Convergence Model: The Emergence Of Highly Pathogenic Avian Influenza (H5n1) In Viet Nam, Sumeet Saksena, Jefferson Fox, Michael Epprecht, Chinh C. Tran, Duong H. Nong, James H. Spencer, Lam Nguyen, Melissa L. Finucane, Vien D. Tran, Bruce A. Wilcox Sep 2015

Evidence For The Convergence Model: The Emergence Of Highly Pathogenic Avian Influenza (H5n1) In Viet Nam, Sumeet Saksena, Jefferson Fox, Michael Epprecht, Chinh C. Tran, Duong H. Nong, James H. Spencer, Lam Nguyen, Melissa L. Finucane, Vien D. Tran, Bruce A. Wilcox

Faculty Publications

Building on a series of ground breaking reviews that first defined and drew attention to emerging infectious diseases (EID), the 'convergence model' was proposed to explain the multifactorial causality of disease emergence. The model broadly hypothesizes disease emergence is driven by the co-incidence of genetic, physical environmental, ecological, and social factors. We developed and tested a model of the emergence of highly pathogenic avian influenza (HPAI) H5N1 based on suspected convergence factors that are mainly associated with land-use change. Building on previous geospatial statistical studies that identified natural and human risk factors associated with urbanization, we added new factors to …

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Herpes Simplex Vaccines: Prospects Of Live-Attenuated Hsv Vaccines To Combat Genital And Ocular Infections, Brent Stanfield, Konstantin Gus Kousoulas Sep 2015

Herpes Simplex Vaccines: Prospects Of Live-Attenuated Hsv Vaccines To Combat Genital And Ocular Infections, Brent Stanfield, Konstantin Gus Kousoulas

Faculty Publications

© 2015, Springer International Publishing AG. Herpes simplex virus type 1 (HSV-1) and its closely related herpes simplex virus type 2 (HSV-2) cause important clinical manifestations in humans including acute ocular disease and genital infections. These viruses establish latency in the trigeminal ganglionic and dorsal root neurons, respectively. Both viruses are widespread among humans and can frequently reactivate from latency causing disease. Currently, there are no vaccines available against herpes simplex viral infections. However, a number of promising vaccine approaches are being explored in preclinical investigations with few progressing to early-phase clinical trials. Consensus research findings suggest that robust humoral …

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Infectious Disease And Red Wolf Conservation: Assessment Of Disease Occurrence And Associated Risks, Kristin E. Brzeski, Rebecca B. Harrison, William T. Waddell, Karen N. Wolf, David R. Rabon, Sabrina S. Taylor Aug 2015

Infectious Disease And Red Wolf Conservation: Assessment Of Disease Occurrence And Associated Risks, Kristin E. Brzeski, Rebecca B. Harrison, William T. Waddell, Karen N. Wolf, David R. Rabon, Sabrina S. Taylor

Faculty Publications

Infectious diseases pose a significant threat to global biodiversity and may contribute to extinction. As such, establishing baseline disease prevalence in vulnerable species where disease could affect persistence is important to conservation. We assessed potential disease threats to endangered red wolves (Canis rufus) by evaluating regional (southeastern United States) disease occurrences in mammals and parasite prevalence in red wolves and sympatric coyotes (Canis latrans) in North Carolina. Common viral pathogens in the southeast region, such as canine distemper and canine parvovirus, and numerous widespread endoparasites could pose a threat to the red Wolf population. The most prevalent parasites in red …

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Expansion Of Brucellosis Detection In The Country Of Georgia By Screening Household Members Of Cases And Neighboring Community Members, Lia Sanodze, Christian T. Bautista, Natalia Garuchava, Svetlana Chubinidze, Ekaterine Tsertsvadze, Mariam Broladze, Nazibrola Chitadze, Ketevan Sidamonidze, Shota Tsanava, Tamar Akhvlediani, Robert G. Rivard, Rupal Mody, Matthew J. Hepburn, Philip H. Elzer, Mikeljon P. Nikolich, Nino Trapaidze May 2015

Expansion Of Brucellosis Detection In The Country Of Georgia By Screening Household Members Of Cases And Neighboring Community Members, Lia Sanodze, Christian T. Bautista, Natalia Garuchava, Svetlana Chubinidze, Ekaterine Tsertsvadze, Mariam Broladze, Nazibrola Chitadze, Ketevan Sidamonidze, Shota Tsanava, Tamar Akhvlediani, Robert G. Rivard, Rupal Mody, Matthew J. Hepburn, Philip H. Elzer, Mikeljon P. Nikolich, Nino Trapaidze

Faculty Publications

© 2015 Sanodze et al.; licensee BioMed Central. Background: Brucellosis is considered as endemic zoonotic disease in the country of Georgia. However, the burden of the disease on a household level is not known. Therefore, this study sought to determine the benefits of active surveillance coupled to serological screening for the early detection of brucellosis among close contacts of brucellosis cases. Methods: We used an active surveillance approach to estimate the rate of seropositivity among household family members and neighboring community members of brucellosis index cases. All participants were screened using the serum tube agglutination test (SAT). Blood cultures were …

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Synthesis, Functionalization, And Characterization Of Metallic And Organic Nanoparticles For Biomedical Applications, Christopher Brian Sylvester May 2015

Synthesis, Functionalization, And Characterization Of Metallic And Organic Nanoparticles For Biomedical Applications, Christopher Brian Sylvester

Honors Capstones

No abstract provided.

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Recycling Antibiotics Into Gumbos: A New Combination Strategy To Combat Multi-Drug-Resistant Bacteria, Marsha R. Cole, Jeffery A. Hobden, Isiah M. Warner Apr 2015

Recycling Antibiotics Into Gumbos: A New Combination Strategy To Combat Multi-Drug-Resistant Bacteria, Marsha R. Cole, Jeffery A. Hobden, Isiah M. Warner

Faculty Publications

© 2015 by the authors; licensee MDPI. The emergence of multi-drug-resistant bacteria, coupled with the lack of new antibiotics in development, is fast evolving into a global crisis. New strategies utilizing existing antibacterial agents are urgently needed. We propose one such strategy in which four outmoded β-lactam antibiotics (ampicillin, carbenicillin, cephalothin and oxacillin) and a well-known antiseptic (chlorhexidine di-acetate) were fashioned into a group of uniform materials based on organic salts (GUMBOS) as an alternative to conventional combination drug dosing strategies. The antibacterial activity of precursor ions (e.g., chlorhexidine diacetate and β-lactam antibiotics), GUMBOS and their unreacted mixtures were studied …

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High Frequency Of Active Hcv Infection Among Seropositive Cases In West Africa And Evidence For Multiple Transmission Pathways, Jennifer E. Layden, Richard O. Phillips, Shirley Owusu-Ofori, Fred Stephen Sarfo, Stephanie Kliethermes, Nallely Mora, Dorcas Owusu, Kenrad Nelson, Ohene Opare-Sem, Lara Dugas, Amy Luke, David Shoham, Joseph C. Forbi, Yury E. Khudyakov, Richard S. Cooper Apr 2015

High Frequency Of Active Hcv Infection Among Seropositive Cases In West Africa And Evidence For Multiple Transmission Pathways, Jennifer E. Layden, Richard O. Phillips, Shirley Owusu-Ofori, Fred Stephen Sarfo, Stephanie Kliethermes, Nallely Mora, Dorcas Owusu, Kenrad Nelson, Ohene Opare-Sem, Lara Dugas, Amy Luke, David Shoham, Joseph C. Forbi, Yury E. Khudyakov, Richard S. Cooper

Faculty Publications

Background. Sub-Saharan Africa (SSA) has one of the highest global hepatitis C virus (HCV) prevalence estimates. However, reports that suggest high rates of serologic false positives and low levels of viremia have led to uncertainty regarding the burden of active infection in this region. Additionally, little is known about the predominant transmission risk factors in SSA. Methods. We prospectively recalled 363 past blood donors (180 who were rapid screen assay [RSA] positive and 183 who were RSA negative at time of donation) to identify the level of active infection and risk factors for infection at a teaching hospital in Kumasi, …

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A Comparison Of Nutrient Intake, Nutrient Adequacy, Diet Quality, And Obesity Prevalence In Low-Income Children (2-18 Yr) Based On Participation In The Supplemental Nutrition Assistance Program: Nhanes 2003-2010, Matthew J. Landry Apr 2015

A Comparison Of Nutrient Intake, Nutrient Adequacy, Diet Quality, And Obesity Prevalence In Low-Income Children (2-18 Yr) Based On Participation In The Supplemental Nutrition Assistance Program: Nhanes 2003-2010, Matthew J. Landry

Honors Capstones

No abstract provided.

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Characterization Of A Novel Retrotransposon In New World Monkeys, Sreeja Sanampudi Apr 2015

Characterization Of A Novel Retrotransposon In New World Monkeys, Sreeja Sanampudi

Honors Capstones

No abstract provided.

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