Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Education (212)
- Higher Education (168)
- Medicine and Health Sciences (148)
- Business (103)
- Marketing (102)
-
- Life Sciences (86)
- Public Health (46)
- Immunology and Infectious Disease (37)
- Microbiology (33)
- Educational Administration and Supervision (31)
- Medical Education (30)
- Higher Education Administration (29)
- Medical Specialties (24)
- Diseases (21)
- Biology (19)
- Epidemiology (19)
- Medical Sciences (18)
- Physical Sciences and Mathematics (18)
- Social and Behavioral Sciences (17)
- Immunology of Infectious Disease (16)
- Organisms (15)
- Internal Medicine (14)
- Biochemistry, Biophysics, and Structural Biology (13)
- Community Health and Preventive Medicine (12)
- Bacteria (11)
- Bacteriology (11)
- Medical Microbiology (11)
- Pathogenic Microbiology (11)
- Arts and Humanities (9)
- Bacterial Infections and Mycoses (9)
- Keyword
-
- Internal Medicine (41)
- Biomedical Sciences (24)
- Surgery (23)
- HIV (19)
- QCOM (18)
-
- College of medicine (14)
- Scholarly activities (14)
- Higher education (13)
- Biostatistics and Epidemiology (12)
- Graduate school (11)
- Health and environmental sciences (10)
- Immunology (9)
- Sepsis (9)
- COVID-19 (8)
- Antibiotic resistance (7)
- Apoptosis (7)
- HCV (7)
- ATM (6)
- Chlamydia (6)
- Chlamydia trachomatis (6)
- Climate change (6)
- East Tennessee State University (6)
- Macrophages (6)
- Candida albicans (5)
- Dectin-1 (5)
- Inflammation (5)
- Medical education (5)
- Office of the President (5)
- Pharmacy Practice (5)
- Aedes aegypti (4)
- Publication Year
- Publication
-
- Electronic Theses and Dissertations (144)
- ETSU Faculty Works (125)
- ETSU News (99)
- Undergraduate Honors Theses (46)
- Appalachian Student Research Forum (15)
-
- Board of Trustees Agendas and Minutes (15)
- Quillen College of Medicine Scholarly Activity Reports (14)
- Graduate Council Agendas and Minutes (11)
- Annual Reports (8)
- ETSU Today [magazine] (8)
- GattonRX Magazine (8)
- Quillen Magazine (8)
- Pharmacy Academic Catalogs (6)
- Accent [newsletter] (5)
- ETSU Health Annual Reports (5)
- Illuminated: Graduate Student Research Magazine (5)
- Medical Student Education Committee Minutes (5)
- Office of the President State of the University Annual Report (5)
- Dr. Jay W. Boland Research Day (3)
- Epsilon Sigma at-Large Research Conference (3)
- Faculty Senate Agendas and Minutes (3)
- Speech-Language Pathology Handbooks (3)
- 3 Minute Thesis Competition (2)
- Academic Council Agenda and Minutes (2)
- Bill Gatton College of Pharmacy Miscellaneous Publications (2)
- Biological Sciences Newsletters (2)
- Tennessee Posters at the Capitol [2022] (2)
- Community Voices [magazine] (1)
- ETSU/NORC Rural Health Research Center Policy Briefs (1)
- International Journal of Health Sciences Education (1)
- Publication Type
- File Type
Articles 331 - 360 of 563
Full-Text Articles in Entire DC Network
Lmp1 Signaling Pathway Activates Irf4 In Latent Ebv Infection And A Positive Circuit Between Pi3k And Src Is Required, Ling Wang, Junping Ren, Guang Li, Jonathan P. Moorman, Zhi Q. Yao, Shunbin Ning
Lmp1 Signaling Pathway Activates Irf4 In Latent Ebv Infection And A Positive Circuit Between Pi3k And Src Is Required, Ling Wang, Junping Ren, Guang Li, Jonathan P. Moorman, Zhi Q. Yao, Shunbin Ning
ETSU Faculty Works
Interferon (IFN) regulatory factors (IRFs) have crucial roles in immune regulation and oncogenesis. We have recently shown that IRF4 is activated through c-Src-mediated tyrosine phosphorylation in virus-transformed cells. However, the intracellular signaling pathway triggering Src activation of IRF4 remains unknown. In this study, we provide evidence that Epstein–Barr virus (EBV) latent membrane protein 1 (LMP1) promotes IRF4 phosphorylation and markedly stimulates IRF4 transcriptional activity, and that Src mediates LMP1 activation of IRF4. As to more precise mechanism, we show that LMP1 physically interacts with c-Src, and the phosphatidylinositol 3 kinase (PI3K) subunit P85 mediates their interaction. Depletion of P85 by …
"Toll-Free" Pathways For Production Of Type I Interferons, Ling Wang, Shunbin Ning
"Toll-Free" Pathways For Production Of Type I Interferons, Ling Wang, Shunbin Ning
ETSU Faculty Works
Pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) are recognized by different cellular pathogen recognition receptors (PRRs), which are expressed on cell membrane or in the cytoplasm of cells of the innate immune system. Nucleic acids derived from pathogens or from certain cellular conditions represent a large category of PAMPs/DAMPs that trigger production of type I interferons (IFN-I) in addition to pro-inflammatory cytokines, by specifically binding to intracellular Toll-like receptors or cytosolic receptors. These cytosolic receptors, which are not related to TLRs and we call them "Toll-free" receptors, include the RNA-sensing RIG-I like receptors (RLRs), the DNA-sensing HIN200 family, …
Interferon-Α-Enhanced Cd100/Plexin-B1/B2 Interactions Promote Natural Killer Cell Functions In Patients With Chronic Hepatitis C Virus Infection, Yu He, Yonghong Guo, Chao Fan, Yingfeng Lei, Yun Zhou, Mingjie Zhang, Chuantao Ye, Guangxi Ji, Li Ma, Jianqi Lian, Jonathan P. Moorman, Zhi Q. Yao, Jiuping Wang, Chunqiu Hao, Ying Zhang, Zhansheng Jia
Interferon-Α-Enhanced Cd100/Plexin-B1/B2 Interactions Promote Natural Killer Cell Functions In Patients With Chronic Hepatitis C Virus Infection, Yu He, Yonghong Guo, Chao Fan, Yingfeng Lei, Yun Zhou, Mingjie Zhang, Chuantao Ye, Guangxi Ji, Li Ma, Jianqi Lian, Jonathan P. Moorman, Zhi Q. Yao, Jiuping Wang, Chunqiu Hao, Ying Zhang, Zhansheng Jia
ETSU Faculty Works
Background: CD100, also known as Sema4D, is an immune semaphorin constitutively expressed on natural killer (NK) cells and T cells. As an immune activation molecule, CD100 has important immunoregulatory effects on NK functions by enhancing the interactions between NK cells and target cells. The aim of this study was to investigate whether hepatitis C virus (HCV) infection affects CD100 expression, and whether interferon-α treatment enhances NK killing activity to facilitate HCV clearance via CD100. Methods: Expression of CD100 on NK cells was evaluated by flow cytometry in patients with chronic HCV infection, with or without pegylated interferon-α-based therapy. NK cell …
Quillen Magazine - Fall 2017, Quillen College Of Medicine, East Tennessee State University
Quillen Magazine - Fall 2017, Quillen College Of Medicine, East Tennessee State University
Quillen Magazine
No abstract provided.
Retrospective Cohort Study Of The Efficacy Of Azithromycin Vs. Doxycycline As Part Of Combination Therapy In Non-Intensive Care Unit Veterans Hospitalized With Community-Acquired Pneumonia, Justin Spivey, Heather Sirek, Robert Wood, Kalpit Devani, Billy Brooks, Jonathan Moorman
Retrospective Cohort Study Of The Efficacy Of Azithromycin Vs. Doxycycline As Part Of Combination Therapy In Non-Intensive Care Unit Veterans Hospitalized With Community-Acquired Pneumonia, Justin Spivey, Heather Sirek, Robert Wood, Kalpit Devani, Billy Brooks, Jonathan Moorman
ETSU Faculty Works
The IDSA Community-Acquired Pneumonia (CAP) Guideline recommends ceftriaxone in combination with doxycycline as an alternative to combination therapy with ceftriaxone and azithromycin for non-intensive care unit (ICU) patients hospitalized with CAP. This is an attractive alternative regimen due to recent concerns of increased cardiovascular risk associated with azithromycin. The objective of this study was to compare the clinical outcomes of azithromycin and doxycycline each in combination with ceftriaxone for non-ICU Veterans hospitalized with CAP.
Redefining Aging In Hiv Infection Using Phenotypes, David M. Stoff, Karl Goodkin, Dilip Jeste, Maria Marquine
Redefining Aging In Hiv Infection Using Phenotypes, David M. Stoff, Karl Goodkin, Dilip Jeste, Maria Marquine
ETSU Faculty Works
Purpose of review: This article critically reviews the utility of “phenotypes” as behavioral descriptors in aging/HIV research that inform biological underpinnings and treatment development. We adopt a phenotypic redefinition of aging conceptualized within a broader context of HIV infection and of aging. Phenotypes are defined as dimensions of behavior, closely related to fundamental mechanisms, and, thus, may be more informative than chronological age. Primary emphasis in this review is given to comorbid aging and cognitive aging, though other phenotypes (i.e., disability, frailty, accelerated aging, successful aging) are also discussed in relation to comorbid aging and cognitive aging. Recent findings: The …
In Vivo Efficacy Of A Cocktail Of Human Monoclonal Antibodies (Cl184) Against Diverse North American Bat Rabies Virus Variants, Richard Franka, William C. Carson, James A. Ellison, Steven T. Taylor, Todd G. Smith, Natalia A. Kuzmina, Ivan V. Kuzmin, Wilfred Marissen, Charles E. Rupprecht
In Vivo Efficacy Of A Cocktail Of Human Monoclonal Antibodies (Cl184) Against Diverse North American Bat Rabies Virus Variants, Richard Franka, William C. Carson, James A. Ellison, Steven T. Taylor, Todd G. Smith, Natalia A. Kuzmina, Ivan V. Kuzmin, Wilfred Marissen, Charles E. Rupprecht
ETSU Faculty Works
Following rabies virus (RABV) exposure, a combination of thorough wound washing, multiple-dose vaccine administration and the local infiltration of rabies immune globulin (RIG) are essential components of modern post-exposure prophylaxis (PEP). Although modern cell-culture-based rabies vaccines are increasingly used in many countries, RIG is much less available. The prohibitive cost of polyclonal serum RIG products has prompted a search for alternatives and design of anti-RABV monoclonal antibodies (MAbs) that can be manufactured on a large scale with a consistent potency and lower production costs. Robust in vitro neutralization activity has been demonstrated for the CL184 MAb cocktail, a 1:1 protein …
1017-September-12-Chair Of Excellence, University Marketing And Communication, East Tennessee State University
1017-September-12-Chair Of Excellence, University Marketing And Communication, East Tennessee State University
ETSU News
No abstract provided.
Evaluation Of Trained Immunity By Β-1, 3 (D)-Glucan On Murine Monocytes In Vitro And Duration Of Response In Vivo, Pablo Garcia-Valtanen, Ruth Marian Guzman-Genuino, David L. Williams, John D. Hayball, Kerrilyn R. Diener
Evaluation Of Trained Immunity By Β-1, 3 (D)-Glucan On Murine Monocytes In Vitro And Duration Of Response In Vivo, Pablo Garcia-Valtanen, Ruth Marian Guzman-Genuino, David L. Williams, John D. Hayball, Kerrilyn R. Diener
ETSU Faculty Works
The β-1, 3 (d)-glucan (β-glucan) present in the cell wall of Candida albicans induces epigenetic changes in human monocytes resulting in primed macrophages exhibiting increased cytokine responsiveness to reinfection. This phenomenon is referred to as trained immunity or innate immune memory. However, whether β-glucan can reprogramme murine monocytes in vitro or induce lasting effects in vivo has yet to be elucidated. Thus, purified murine spleen-derived monocytes were primed with β-glucan in vitro and assessed for markers of differentiation and survival. Important macrophage cell markers during monocyte-to-macrophage differentiation were downregulated and survival enhanced due to partial inhibition of apoptosis. Increased survival …
Effects Of Acute Sepsis On Renal Structure And Sympathetic Innervation In Mice, Tuqa Alkhateeb
Effects Of Acute Sepsis On Renal Structure And Sympathetic Innervation In Mice, Tuqa Alkhateeb
Electronic Theses and Dissertations
Sympathetic nerves are important for renal physiology and sepsis pathophysiology. A recent study showed sprouting of sympathetic nerves in spleen of septic mice. This study was done to test if renal sprouting of sympathetic nerves also happens and to investigate renal morphology in septic mice. Cecal ligation and puncture (CLP) was used to induce sepsis and kidneys were removed for evaluation. Bowman’s space was diminished with cortical bubble cells present suggestive of acute renal pathology, however, renal function was unchanged. Acute sepsis did not affect either renal sympathetic innervation or non-neuronal cholinergic cells. Mouse kidneys had more epinephrine (EPI) than …
2017-July-07-Sam Pettyjohn, University Marketing And Communications, East Tennessee State University
2017-July-07-Sam Pettyjohn, University Marketing And Communications, East Tennessee State University
ETSU News
No abstract provided.
Β-Glucan Size Controls Dectin-1-Mediated Immune Responses In Human Dendritic Cells By Regulating Il-1Β Production, Matthew J. Elder, Steve J. Webster, Ronnie Chee, David L. Williams, J. S. Hill Gaston, Jane C. Goodall
Β-Glucan Size Controls Dectin-1-Mediated Immune Responses In Human Dendritic Cells By Regulating Il-1Β Production, Matthew J. Elder, Steve J. Webster, Ronnie Chee, David L. Williams, J. S. Hill Gaston, Jane C. Goodall
ETSU Faculty Works
Dectin-1/CLEC7A is a pattern recognition receptor that recognizes β-1,3 glucans, and its stimulation initiates signaling events characterized by the production of inflammatory cytokines from human dendritic cells (DCs) required for antifungal immunity. β-glucans differ greatly in size, structure, and ability to activate effector immune responses from DC; as such, small particulate β-glucans are thought to be poor activators of innate immunity. We show that β-glucan particle size is a critical factor contributing to the secretion of cytokines from human DC; large β-glucan-stimulated DC generate significantly more IL-1β, IL-6, and IL-23 compared to those stimulated with the smaller β-glucans. In marked …
Productive And Penicillin-Stressed Chlamydia Pecorum Infection Induces Nuclear Factor Kappa B Activation And Interleukin-6 Secretion In Vitro, Cory A. Leonard, Robert V. Schoborg, Nicole Borel
Productive And Penicillin-Stressed Chlamydia Pecorum Infection Induces Nuclear Factor Kappa B Activation And Interleukin-6 Secretion In Vitro, Cory A. Leonard, Robert V. Schoborg, Nicole Borel
ETSU Faculty Works
Nuclear factor kappa B (NFκB) is an inflammatory transcription factor that plays an important role in the host immune response to infection. The potential for chlamydiae to activate NFκB has been an area of interest, however most work has focused on chlamydiae impacting human health. Given that inflammation characteristic of chlamydial infection may be associated with severe disease outcomes or contribute to poor overall fitness in farmed animals, we evaluated the ability of porcine chlamydiae to induce NFκB activation in vitro. C. pecorum infection induced both NFκB nuclear translocation and activation at 2 hours post infection (hpi), an effect strongly …
Chat Expression In Chlamydia Muridarum-Infected Female Murine Genital Tract, Hallie Sartain
Chat Expression In Chlamydia Muridarum-Infected Female Murine Genital Tract, Hallie Sartain
Undergraduate Honors Theses
Chlamydia trachomatis is the most prevalent agent of bacterial sexually transmitted infections in the world. However, a profuse number of cases are unreported, as the infection is often asymptomatic. Sequelae such as pelvic inflammatory disease, an increased risk of cervical cancer, premature birth, and perinatal infections in pregnant women can occur. Inflammation occurs in the body in response to infection or injury. Although inflammation can lead to some unwanted secondary effects, such as pain, it serves to return the body to homeostasis by restoring injured tissues and eliminating pathogens. One recently identified connection between the central nervous system and the …
Assessment Of Social, Dietary And Biochemical Correlates Of Cardiometabolic Risk In Pre-Adolescent Hispanic Children, Abraham Basil Alhassan
Assessment Of Social, Dietary And Biochemical Correlates Of Cardiometabolic Risk In Pre-Adolescent Hispanic Children, Abraham Basil Alhassan
Electronic Theses and Dissertations
Obesity, elevated blood pressure and dyslipidemia are highly prevalent in Hispanic children. Compared to their non-Hispanic White peers, Hispanic children experience higher prevalence of obesity and hypertension. The Hispanic population in Tennessee has been growing, with about a tenth of newborn babies being Hispanic. This study aimed to: 1. Examine the influence of sociodemographic factors on Hispanic children’s cardiometabolic risk; 2. Assess the relationship between food group intake and cardiometabolic risk in Hispanic children; and 3. Evaluate the efficacy of non-traditional biomarkers for detecting cardiometabolic risk in Hispanic children. Data for the study came from a larger cross-sectional pilot study …
Range-Wide Prevalence And Impacts Of Pseudocercosporella Inconspicua On Lilium Grayi And An Assessment Of L. Superbum And L. Michauxii As Reservoirs, Cindy L. Barrett
Range-Wide Prevalence And Impacts Of Pseudocercosporella Inconspicua On Lilium Grayi And An Assessment Of L. Superbum And L. Michauxii As Reservoirs, Cindy L. Barrett
Electronic Theses and Dissertations
Lilium grayi (Gray’s Lily), a southern Appalachian endemic species, is threatened by a Lilium-specific fungal pathogen, Pseudocercosporella inconspicua. The disease is characterized by tan lesions that can cause early senescence, while also lowering seed production and viability. This project tested for P. inconspicua conidia and accessed health at nine locations. The disease was present and ubiquitous across the range of L. grayi. Through identification of P. inconspicua conidia in the field, L. superbum (Turk’s Cap Lily) was identified as an additional host, while L. michauxii (Michaux’s Lily) was disease-free. However, infection was inducible in both species. With …
The Increasing Risk Of Vector-Borne Diseases: Mapping The Effects Of Climate Change And Human Population Density On Future Aedes Aegypti Habitats, Julie Obenauer
Electronic Theses and Dissertations
The Aedes aegypti mosquito is the vector for four infectious diseases of global concern – Yellow Fever, Dengue, Chikungunya, and Zikavirus. Previous attempts to model the expansion of the vector habitat due to global climate change have rarely included characteristics related to the human populations on which this mosquito is dependent. The purpose of this research was to determine whether the inclusion of human population density improves model performance while creating risk maps that can be used to determine where humans are most likely to be exposed to the vector in the future. The resulting model demonstrated that the inclusion …
Is Prison Why I’M Sick? Examining Health Conditions Among Minority Males Within Correctional Facilities, Mary Hannah Hughes
Is Prison Why I’M Sick? Examining Health Conditions Among Minority Males Within Correctional Facilities, Mary Hannah Hughes
Electronic Theses and Dissertations
Given the current United States prison population of 1.5 million persons, many states have begun to examine how to effectively reduce correctional expenditures, considering in 2011 healthcare related prison costs increased to approximately eight billion (The Pew Charitable Trusts, 2014). Recent research attributes much of this increase to the prevalence of disease and aging within the prison population (Williams et al., 2012; Dumont et al., 2012; Gallagher, 2001; Ahalt et al., 2013). Alternatively, little attention has been devoted to measuring the disparity in health among minority male inmates or the effects of identifying more cost effective health initiatives that address …
An Investigation Of The Relationship Between Child, Family, And Community Factors And Early Childhood Oral Health And The Utilization Of Dental Health Services, Nicole Holt
Electronic Theses and Dissertations
Background / Objective: Children under the age of 5 years bear a disproportionate burden of oral disease. The aim of this study is to investigate how child, family, and community determinants impact dental care utilization, and parental report of child’s oral health. Methods: Data for this study came from the 2011/2012 National Survey of Children’s Health for children aged 1 to 5 years old. Dependent variables evaluated were if the child had an oral health problem, been to a dentist in the past year, and parents description of the child’s teeth. Independent variables were selected from child, family, and community …
Screening Of Siderophore Producers From Soil, Rana Elgazzar
Screening Of Siderophore Producers From Soil, Rana Elgazzar
Undergraduate Honors Theses
Iron is a vital nutrient for the maintenance of enzymatic function, electron transport, DNA synthesis, and other metabolic processes. Thus, bacteria and other microorganisms cope with iron deficiency by secreting high-affinity iron chelators called siderophores. This investigation aimed to characterize siderophore-producing soil bacteria. The soil provides the most complex ecological environment where one can look for promising siderophores to be used for treating either iron overload conditions or to be used as an antibiotic carrier.
Toll Like Receptor 4 Stimulation Increases Scavenger Receptor A Expression On Murine Macrophages, Mackenzie L. Guthrie
Toll Like Receptor 4 Stimulation Increases Scavenger Receptor A Expression On Murine Macrophages, Mackenzie L. Guthrie
Undergraduate Honors Theses
Sepsis is the body’s response to an overwhelming infection and is a serious consequence of critical illness. It can cause tissue damage, organ failure, and death. Sepsis continues to have an unacceptably high mortality rate, due to the lack of effective treatments. Specific therapeutic targets for sepsis remain elusive since the complex functional changes that result in a septic state remain poorly understood. Macrophage Scavenger Receptor A (SRA, CD204) is a surface receptor that binds negatively charged, endogenous and exogenous ligands. We have discovered that SRA plays a significant role in the pathophysiology of sepsis. We have shown that mice …
Determination Of The Effects That A Previously Uncharacterized Secreted Product From Klebsiella Pneumoniae Has On Citrobacter Freundii And Enterobacter Cloacae Biofilms, Cody M. Hastings
Undergraduate Honors Theses
More so than ever, Multiple Drug Resistant (MDR) bacteria are on the rise due to overuse of antibiotics along with natural selection for adaptations that enhance drug-resistant properties. One particular bacterial family, Enterobacteriaceae, has been problematic, exhibiting several bacterial members that have developed a precipitous resistance to modern antibiotics and are also primary causative agents of nosocomial, or hospital acquired, infections. Citrobacter freundii (CF) and Enterobacter cloacae (ECL) are two species of the Enterobacteriaceae family causing significant medical concern due to their role in producing numerous opportunistic infections such as bacteremia, lower respiratory tract infections, urinary tract infections, and endocarditis. …
2017-April-27-Editorial Board, University Marketing And Communications, East Tennessee State University
2017-April-27-Editorial Board, University Marketing And Communications, East Tennessee State University
ETSU News
No abstract provided.
Capture-Recapture Methodology To Study Rare Conditions Using Surveillance Data For Fragile X Syndrome And Muscular Dystrophy, Michael G. Smith, Julie Royer, Joshua Mann, Suzanne Mcdermott, Rodolfo Valdez
Capture-Recapture Methodology To Study Rare Conditions Using Surveillance Data For Fragile X Syndrome And Muscular Dystrophy, Michael G. Smith, Julie Royer, Joshua Mann, Suzanne Mcdermott, Rodolfo Valdez
ETSU Faculty Works
Rare conditions can be catastrophic for families and the implications for public health can be substantial. Our study compared basic surveillance through active medical record review with a linked administrative data file to assess the number of cases of two rare conditions, fragile X syndrome (FXS) and muscular dystrophy (MD) in a population. Methods: Two methods of data collection were used to collect information from five counties comprising two standard metropolitan statistical areas of South Carolina. The passive system relied mostly on health claims data using ICD-9 CM diagnostic codes. The active system relied on a nurse abstracting records from …
Malaria Over-Diagnosis In Cameroon: Diagnostic Accuracy Of Fluorescence And Staining Technologies (Fast) Malaria Stain And Led Microscopy Versus Giemsa And Bright Field Microscopy Validated By Polymerase Chain Reaction, Sean M. Parsel, Steven A. Gustafson, Edward Friedlander, Alexander A. Shnyra, Aderosoye J. Adegbulu, Ying Liu, Nicole M. Parrish, Syed Jamal, Eve Lofthus, Leo Ayuk, Charles Awasom, Carolyn J. Henry, Carole P. Mcarthur
Malaria Over-Diagnosis In Cameroon: Diagnostic Accuracy Of Fluorescence And Staining Technologies (Fast) Malaria Stain And Led Microscopy Versus Giemsa And Bright Field Microscopy Validated By Polymerase Chain Reaction, Sean M. Parsel, Steven A. Gustafson, Edward Friedlander, Alexander A. Shnyra, Aderosoye J. Adegbulu, Ying Liu, Nicole M. Parrish, Syed Jamal, Eve Lofthus, Leo Ayuk, Charles Awasom, Carolyn J. Henry, Carole P. Mcarthur
ETSU Faculty Works
Background: Malaria is a major world health issue and its continued burden is due, in part, to difficulties in the diagnosis of the illness. The World Health Organization recommends confirmatory testing using microscopy-based techniques or rapid diagnostic tests (RDT) for all cases of suspected malaria. In regions where Plasmodium species are indigenous, there are multiple etiologies of fever leading to misdiagnoses, especially in populations where HIV is prevalent and children. To determine the frequency of malaria infection in febrile patients over an 8-month period at the Regional Hospital in Bamenda, Cameroon, we evaluated the clinical efficacy of the Flourescence and …
Annual Report - 2016-2017, Bill Gatton College Of Pharmacy, East Tennessee State University
Annual Report - 2016-2017, Bill Gatton College Of Pharmacy, East Tennessee State University
GattonRX Magazine
No abstract provided.
Identification Of Pp1 As The First Phosphatase For Irf7, Shunbin Ning, Ling Wang
Identification Of Pp1 As The First Phosphatase For Irf7, Shunbin Ning, Ling Wang
ETSU Faculty Works
Excerpt: Interferon (IFN) regulatory factor 7 (IRF7) is phosphorylated and activated in response to pathogenic infections for production of type I IFNs
Microrna-155 Attenuates Late Sepsis-Induced Cardiac Dysfunction Through Jnk And Β-Arrestin 2, Yu Zhou, Yan Song, Zahir Shaikh, Hui Li, Haiju Zhang, Yi Caudle, Shouhua Zheng, Hui Yan, Dan Hu, Charles Stuart, Deling Yin
Microrna-155 Attenuates Late Sepsis-Induced Cardiac Dysfunction Through Jnk And Β-Arrestin 2, Yu Zhou, Yan Song, Zahir Shaikh, Hui Li, Haiju Zhang, Yi Caudle, Shouhua Zheng, Hui Yan, Dan Hu, Charles Stuart, Deling Yin
ETSU Faculty Works
Cardiac dysfunction is correlated with detrimental prognosis of sepsis and contributes to a high risk of mortality. After an initial hyperinflammatory reaction, most patients enter a protracted state of immunosuppression (late sepsis) that alters both innate and adaptive immunity. The changes of cardiac function in late sepsis are not yet known. MicroRNA-155 (miR-155) is previously found to play important roles in both regulations of immune activation and cardiac function. In this study, C57BL/6 mice were operated to develop into early and late sepsis phases, and miR-155 mimic was injected through the tail vein 48 h after cecal ligation and puncture …
Analysis Of The Liberian Ebola Survivors Support System (Esss), Jessi Hanson, Patrick Seeco Faley, Megan Quinn
Analysis Of The Liberian Ebola Survivors Support System (Esss), Jessi Hanson, Patrick Seeco Faley, Megan Quinn
ETSU Faculty Works
A systems theoretical analysis to capture the evolution and transition of the network systems supporting Ebola survivors and their affected communities, during the 2014-15 Ebola outbreak and recovery phases. The qualitative analysis includes a literature review, archival review, and interviews with representatives of key actors operating in strategic action fields. This paper uses a series of Diagrams that visually illustrate the various complex phases and their network changes that occurred and were established during the outbreak. This case analysis provides crucial phase information that both captures the historical events that informed the systems changes, including the development of the Ebola …
Viral And Cellular Micrornas In Regulation Of Ebv Latency And Oncogenesis, Ling Wang, Shunbin Ning
Viral And Cellular Micrornas In Regulation Of Ebv Latency And Oncogenesis, Ling Wang, Shunbin Ning
ETSU Faculty Works
Epstein-Barr virus (EBV), an oncogenic virus that ubiquitously establishes life-long persistence in humans, encodes viral miRNAs in two clusters, BHRF1 and BART. EBV also regulates expression of a large pool of cellular miRNAs, including miR-155, miR-146a, miR-21, miR-29, and miR-34a. These miRNAs targets both viral and cellular genes involved in the entire viral lifetime from lytic infection to oncogenesis, including viral replication, immune responses, cell cycle regulation, apoptosis, and cell proliferation, and are indispensable for persistent infection, latency establishment and maintenance, and cancer development. Among them, circulating miRNAs and unique miRNA profiles are promising diagnosis and prognosis biomarkers alone or …