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Articles 6901 - 6930 of 10986
Full-Text Articles in Entire DC Network
The Claustrum In Autism And Typically Developing Male Children: A Quantitative Mri Study, Warren B. Davis
The Claustrum In Autism And Typically Developing Male Children: A Quantitative Mri Study, Warren B. Davis
Theses and Dissertations
The claustrum (Cl) is a subcortical gray-matter structure housed between the external capsule medially and the extreme capsule laterally. Due to its extensive reciprocal connections throughout the brain, it has been implicated in consciousness and other higher order functions including linking behavior and emotion. Such linkage may be important in understanding the neurobiology of autism since other cortical and subcortical regions including the spatially and ontologically related basal ganglia, as well as limbic structures, have been implicated in the disorder. Participants were males with autism (n=16) and typically developing (TD; n=14) matched for head circumference and age. The Cl and …
Many Species In One: Dna Barcoding Overestimates The Number Of Species When Nuclear Mitochondrial Pseudogenes Are Coamplified, Michael F. Whiting, Hojun Song, Keith A. Crandall, Jennifer E. Buhay
Many Species In One: Dna Barcoding Overestimates The Number Of Species When Nuclear Mitochondrial Pseudogenes Are Coamplified, Michael F. Whiting, Hojun Song, Keith A. Crandall, Jennifer E. Buhay
Faculty Publications
Nuclear mitochondrial pseudogenes (numts) are nonfunctional copies of mtDNA in the nucleus that have been found in major clades of eukaryotic organisms.
An Evaluation Of An Upper-Division, General Education Information Literacy Program, Elizabeth S. Hopkins, Suzanne Julian
An Evaluation Of An Upper-Division, General Education Information Literacy Program, Elizabeth S. Hopkins, Suzanne Julian
Faculty Publications
The Advanced Writing library instruction program at Brigham Young University's Harold B. Lee Library (HBLL) is intended to teach junior-level students advanced information literacy and research skills. The university general education curriculum requires students to participate in the program as part of their Advanced Writing course. When anecdotal feedback from librarians and students identified problems with the program, the authors conducted a qualitative evaluation of the program in order to identify problems and possible solutions. The evaluation included a student survey and focus groups with students, librarians, and English faculty. This paper describes the HBLL Advanced Writing instruction program, identifies …
Ultracompact Awg Using Air-Trench Bends With Perfluorocyclobutyl Polymer Waveguides, Seunghyun Kim, Gregory P. Nordin, John Ballato, Yongbin Lin, Nazli Rahmanian, Dennis W. Smith, Chris Topping
Ultracompact Awg Using Air-Trench Bends With Perfluorocyclobutyl Polymer Waveguides, Seunghyun Kim, Gregory P. Nordin, John Ballato, Yongbin Lin, Nazli Rahmanian, Dennis W. Smith, Chris Topping
Faculty Publications
Using air-trench bends, an ultracompact 8 8 arrayed waveguide grating (AWG) demultiplexer (200-GHz channel spacing) for wavelength-division multiplexing (WDM) has been designed and fabricated with perfluorocyclobutyl (PFCB) core and clad co-polymers on a polyimide substrate. Compared to a conventional AWG in the same material system, the air-trench bend AWG shrinks the required chip area by a factor of 20. The decreased size is a factor in reducing the measured thermal shift to -0.012 nm/ C and decreasing the polarization-dependent wavelength shift to 1.3 nm.
Biologically Relevant Multiple Sequence Alignment, Hyrum D. Carroll
Biologically Relevant Multiple Sequence Alignment, Hyrum D. Carroll
Theses and Dissertations
Researchers use multiple sequence alignment algorithms to detect conserved regions in genetic sequences and to identify drug docking sites for drug development. In this dissertation, a novel algorithm is presented for using physicochemical properties to increase the accuracy of multiple sequence alignments. Secondary structures are also incorporated in the evaluation function. Additionally, the location of the secondary structures is assimilated into the function. Multiple properties are combined with weights, determined from prediction accuracies of protein secondary structures using artificial neural networks. A new metric, the PPD Score is developed, that captures the average change in physicochemical properties. Using the physicochemical …
Implementation Of Optical Spectra Calculations In Fireball: A Local-Orbital Density Functional Theory Approach, Ivan Grigoryevich Okhrimenko
Implementation Of Optical Spectra Calculations In Fireball: A Local-Orbital Density Functional Theory Approach, Ivan Grigoryevich Okhrimenko
Theses and Dissertations
We have expanded the capabilities of the ab initio tight-binding molecular dynamics package FIREBALL to include calculations of optical properties. Basic zero order approximation is based on transitions between Kohn-Sham states. Corrections for electron-electron interactions are based on time dependant density functional theory (TDDFT). Consistent with the FIREBALL approach, we use precalculated integrals and approximations to make the program faster.
Wnt5a Signaling Independently Of The Planar Cell Polarity Pathway Resulting In Convergent Extension And Neural Tube Closure During Vertebrate Development, Jared James Barrott
Wnt5a Signaling Independently Of The Planar Cell Polarity Pathway Resulting In Convergent Extension And Neural Tube Closure During Vertebrate Development, Jared James Barrott
Theses and Dissertations
Vertebrate development is regulated by cellular communication by mechanisms of cell fate and cell behavior. These crucial mechanisms are regulated by cellular signaling and in the case of cell fate, cellular signaling results in transcription of developmentally important genes. Communication between cells can also result in regulation of cell behavior by acting on cytoskeletal elements rather than nuclear factors. One of the cellular signals that regulate both cell fate and cell behavior is the family of Wnt signaling molecules. Wnt5a is one of 19 Wnt molecules and has been previously demonstrated to play critical roles in many important processes in …
Determining The Role Of Wnt5a Signaling In Embryonic Limb Outgrowth Via Clonal Analysis, Whitney Herrod Sowby
Determining The Role Of Wnt5a Signaling In Embryonic Limb Outgrowth Via Clonal Analysis, Whitney Herrod Sowby
Theses and Dissertations
The exact mechanisms that regulate limb outgrowth the mouse embryo are unknown. Although there are several models, we favor a hypothesis where cells become polarized by signals secreted from the AER which orient their cell migration and/or divisions causing limb outgrowth. Clonal analysis has provided a mechanism to study cell behavior. We have generated a targeting construct containing the Fgf8 inhibitor, Sprouty2, in order to generate mutant clones for behavioral analyses in the limb. In order to more effectively study clonal behavior we report the modification of a novel clonal analysis approach, exo-utero surgery. We have modified, enhanced and proven …
I. Thermodynamics And Magnetism Of Cu2ocl2 Ii. Repairs To Microcalorimeter The "2"S Are Subscripts, And The Second 2 Is Preceded By A Lower Case L, Not A One, Thomas J. Parry
Theses and Dissertations
Adiabatic calorimetry provides accurate and precise specific heat (Cp) data. From this data, thermodynamic functions may be calculated. Cu2OCl2, melanothallite, became of interest as part of a study of a particular thermochemical cycle. The experimental specific heat data and the calculated thermodynamic functions are reported here. Free energies of formation, calculated from the thermodynamic functions, suggest the particular cycle of interest with this compound as an intermediate is not feasible; uncertainty as to the accuracy of CuO and CuCl2 data used in the calculations indicate further study may be necessary. Upon collection of the specific heat data, an antiferromagnetic transition …
The Antioxidant Defense Network: Synergistic Combinations To Prevent Oxidative Damage, Amy Marie Clement
The Antioxidant Defense Network: Synergistic Combinations To Prevent Oxidative Damage, Amy Marie Clement
Theses and Dissertations
One of the matchless ironies of the human body is its requirement for the highly reactive oxygen molecule, which has been clearly implicated in many diseases and the aging processes. Oxidants produced by metabolic processes damage cells by starting chemical chain reactions including oxidation of DNA and proteins as well as lipid peroxidation. Damage to DNA can cause mutations and lead to cancer if not reversed by DNA repair mechanisms. Damage to proteins causes enzyme inhibition, denaturation and protein degradation. Lipid peroxidation can cause cell lysis as well as creating mutagenic and carcinogenic by-products. The human body contains antioxidants and …
Domain Duplication, Darwinian Selection, And The Origin Of The Globulin Seed Storage Proteins, Nathaniel S. Cannon
Domain Duplication, Darwinian Selection, And The Origin Of The Globulin Seed Storage Proteins, Nathaniel S. Cannon
Theses and Dissertations
The seed storage globulins found among virtually all spermatophytes comprise a multi-gene family of proteins with ancient evolutionary origins. The two main groups of storage globulins include the legumins (11S) and vicilins (7S), both of which play a main role in protein deposition and storage in the seed endosperm. Composed of two cupin domains (bicupin), these proteins have been recently noted not only for their close structural relationships among the two subfamilies (7S and 11S) but also for their similarity to other proteins such as germin-like proteins (GLP's), bacterial oxalate decarboxylases, and other cupin containing proteins. Previous studies have investigated …
A Radical Conjugate Addition Approach To The Total Synthesis Of Celogentin C, Steven G. Capps
A Radical Conjugate Addition Approach To The Total Synthesis Of Celogentin C, Steven G. Capps
Theses and Dissertations
The synthesis of five chiral DBFOX (dibenzofuran-oxazoline) ligands with either aryl or benzyl substituents will be presented. The requisite amino alcohols were obtained with high enantioselectivity either commercially (DBFOX/Bn), via Sharpless asymmetric aminohydroxylation (DBFOX/Nap, DBFOX/t-BuPh, DBFOX/Pip), or via phase-transfer catalyzed asymmetric alkylation (DBFOX/MeNap). These ligands, complexed with Mg(NTf2)2, were used as Lewis acid promoters of enantioselective radical conjugate additions to α/β-unsaturated nitro-amides/esters. A summary of these results is presented and discussed. These findings led us to believe that our initial binding model between metal, ligand, and substrate was flawed. Thus, we figured that if we started with a functionality known …
Cellular And Matrix Changes In Articular Cartilage Of The Disproportionate Micromelia Mouse Model Of Osteoarthritis, Crystal Noelle Smaldone
Cellular And Matrix Changes In Articular Cartilage Of The Disproportionate Micromelia Mouse Model Of Osteoarthritis, Crystal Noelle Smaldone
Theses and Dissertations
Osteoarthritis (OA) is a degenerative joint disease that affects more than 60% of Americans 65 and older. Because human subjects and samples are not readily available for research, animal models are an invaluable resource for the study of OA. Disproportionate micromelia (Dmm) is one such model that develops OA early in life due to a deletion in the c-propeptide of the Col2a1 gene. Light microscope analysis of the articular cartilage in Dmm has been completed, but is insufficient to show the cellular effects of the deletion mutation in Dmm in adequate detail. The present study explores the changes that occur …
Fmri Evidence Of Group Differences On The Word Memory Test In A Sample Of Traumatic Brain Injury Patients, James Douglas Larsen
Fmri Evidence Of Group Differences On The Word Memory Test In A Sample Of Traumatic Brain Injury Patients, James Douglas Larsen
Theses and Dissertations
The Word Memory Test (WMT) is a popular effort test that requires participants to memorize lists of paired words and repeat them back in a variety of different memory tasks. Four brain injured patients participated in two trials of the delayed recall (DR) portion of the WMT while undergoing fMRI scanning. In the first trial subjects put forth full effort, and during the second trial subjects were instructed to simulate increased memory impairment in order to represent poor effort. fMRI activation from both trials were compared in order to contrast full and simulated poor effort activation patterns during the WMT. …
Patterns Of Social Participation: Assessing The Long-Term Effects Of Creating Social Capital, Camille Miller
Patterns Of Social Participation: Assessing The Long-Term Effects Of Creating Social Capital, Camille Miller
Theses and Dissertations
Given the numerous benefits noted in academic research from having social capital, investigators may now turn to looking at what makes a person likely to create it. In this study I examine whether building social capital in high school through participation in religious, athletic, and volunteer activities makes individuals more likely to continue to create it as adults through participation in similar activities. Using data from the National Education Longitudinal Study, I employ both multilevel and seemingly unrelated regression models. I find that early participation in religious and athletic activities increases the likelihood of doing two out of three social …
Regulators Of G-Protein Signaling, Rgs13 And Rgs16, Are Associated With Cxcl12-Mediated Cd4+ T Cell Migration, Lijin Xia
Theses and Dissertations
Chemokines are important chemical signals that guide lymphocyte movement within the immune system and promote the organization and functions of germinal centers (GCs) in the secondary lymphoid tissues. Previous studies have shown that GC T cells exhibit high expression of chemokine receptor 4, CXCR4, but that these cells are unable to migrate to the ligand for this receptor, the chemokine CXCL12. This “migratory paralysis” to CXCL12 was found to be correlated with the expression of two Regulators of G-protein Signaling, RGS13 and RGS16 in the GC T cells. The objective of my research was to determine whether RGS13 and RGS16 …
In-Plane Photonic Transduction Of Silicon-On-Insulator Microcantilevers, Ryan Anderson, Seunghyun Kim, Gregory P. Nordin, Jong Wook Noh, Jaime Cardenas
In-Plane Photonic Transduction Of Silicon-On-Insulator Microcantilevers, Ryan Anderson, Seunghyun Kim, Gregory P. Nordin, Jong Wook Noh, Jaime Cardenas
Faculty Publications
We demonstrate an in-plane photonic transduction method for microcantilevers, which have been widely investigated for sensor applications. In our approach the microcantilever is etched to form a single mode rib waveguide. Light propagates down the microcantilever and crosses a small gap at the free end of the microcantilever, some of which is captured by an asymmetrical multimode waveguide that terminates in a Y-branch. The Y-branch outputs are used to form a differential signal that is monotonically dependent on microcantilever deflection. The measured differential signal matches simulation when microcantilever rotation is properly accounted for. The measured differential signal sensitivity is 1.4 …
Decline In A Dominant Invertebrate Species Contributes To Altered Carbon Cycling In A Low-Diversity Soil Ecosystem, Byron J. Adams, J. E. Barrett, Ross A. Virginia, Diana H. Wall
Decline In A Dominant Invertebrate Species Contributes To Altered Carbon Cycling In A Low-Diversity Soil Ecosystem, Byron J. Adams, J. E. Barrett, Ross A. Virginia, Diana H. Wall
Faculty Publications
Low-diversity ecosystems cover large portions of the Earth's land surface, yet studies of climate change on ecosystem functioning typically focus on temperate ecosystems, where diversity is high and the effects of individual species on ecosystem functioning are difficult to determine. We show that a climate-induced decline of an invertebrate species in a low-diversity ecosystem could contribute to significant changes in carbon © cycling. Recent climate variability in the McMurdo Dry Valleys of Antarctica is associated with changes in hydrology, biological productivity, and community composition of terrestrial and aquatic ecosystems. One of the greatest changes documented in the dry valleys is …
Spectroscopic Study Of Compressible Mobile Phase And Stationary Phase Behavior In Chromatography, Lawrence R. Baker
Spectroscopic Study Of Compressible Mobile Phase And Stationary Phase Behavior In Chromatography, Lawrence R. Baker
Theses and Dissertations
Raman spectroscopy, laser-induced fluorescence, and sum-frequency generation (SFG) spectroscopy are used to investigate the behavior of compressible mobile phases and stationary phases under a variety of chromatographic conditions. Efforts to understand and optimize separations employing compressible mobile phases have been limited by a lack of understanding of the mobile phase density gradient. Mobile phase compressibility leads to gradients in linear velocity and solute retention and affects separation speed and efficiency, especially in packed columns. This work describes on-column density measurement of CO2, a common carrier fluid for SFC and SGC, in packed capillary columns using Raman microspectroscopy. On-column detection by …
Deriving Operational Principles For The Design Of Engaging Learning Experiences, Richard Heywood Swan
Deriving Operational Principles For The Design Of Engaging Learning Experiences, Richard Heywood Swan
Theses and Dissertations
The issue of learner engagement is an important question for education and for instructional design. It is acknowledged that computer games in general are engaging. Thus, one possible solution to learner engagement is to integrate computer games into education; however, the literature indicates that pedagogical, logistical and political barriers remain. Another possible solution is to derive principles for the design of engaging experiences from a critical examination of computer game design. One possible application of the derived design principles is that instruction may be designed to be inherently more engaging. The purpose of this dissertation was to look for operational …
Comparison Of Guided And Open Inquiry Instruction In A High School Physics Classroom, Brett M. Guisti
Comparison Of Guided And Open Inquiry Instruction In A High School Physics Classroom, Brett M. Guisti
Theses and Dissertations
This study compared two levels of inquiry in high school physics classrooms over a year-long course. One class fit well the definition of guided-inquiry and the other matched common descriptions of open-inquiry. Four sections of introductory physics at Lone Peak High School in Highland, Utah were randomly divided into two sections for each treatment. The majority of students in all classes were sophomores with relatively few juniors and seniors. The guided-inquiry classes followed the Modeling Instruction Program developed at Arizona State University, while the open-inquiry classes were be based on an approach used by Wolff-Michael Roth, at the University of …
Differential Expression And Functional Characterization Of Alpha3 Beta2 Neuronal Nicotinic Acetylcholine Receptors, John Hideo Mizukawa
Differential Expression And Functional Characterization Of Alpha3 Beta2 Neuronal Nicotinic Acetylcholine Receptors, John Hideo Mizukawa
Theses and Dissertations
Neuronal nicotinic acetylcholine receptors (nAChRs) are expressed in both the periperhal and central nervous systems, and are involved in pre-, post-, and non-synaptic control of neuronal activation. In the brain, these receptors play an important role in a variety of physiological processes such as cognition, development, learning, and memory formation. Malfunction of these receptors have been implicated in neurodegenerative diseases like Alzheimer's disease (AD), schizophrenia, and Parkinson's disease. To date, 17 different nAChR subunits, including α2-α7 and β2-β4, have been cloned that can form homo- and/or hetero-pentameric ionotropic receptors. The unique combinations of subunit pentamers manifest in distinct functional receptors. …
Assessing Multivariate Heritability Through Nonparametric Methods, Benjamin Alan Carper
Assessing Multivariate Heritability Through Nonparametric Methods, Benjamin Alan Carper
Theses and Dissertations
The similarities between generations of living subjects are often quantified by heritability. By distinguishing genotypic variation, or variation due to parental pairings, from phenotypic variation, or normal intraspecies variation, the heritability of traits can be estimated. Due to the multivariate nature of many traits, such as size and shape, computation of heritability can be difficult. Also, assessment of the variation of the heritability estimate is extremely difficult. This study uses nonparametric methods, namely the randomization test and the bootstrap, to obtain both a measure of the extremity of the observed heritability and an assessment of the uncertainty.
Arthropod And Plant Communities As Indicators Of Land Rehabilitation Effectiveness In A Semi-Arid Shrub-Steppe, Eric T. Gardner
Arthropod And Plant Communities As Indicators Of Land Rehabilitation Effectiveness In A Semi-Arid Shrub-Steppe, Eric T. Gardner
Theses and Dissertations
We describe a case study evaluating the ecological impact of Bromus tectorum L. (cheatgrass) invasion following fire disturbance and the effectiveness of revegetation in improving ecological integrity in a degraded semi-arid shrub steppe system. The effectiveness of rehabilitation efforts was assessed from measurements of arthropod richness, vegetation and arthropod community composition, and ground cover characteristics in three habitats: undisturbed, burned and weed-infested (B. tectorum), and burned and rehabilitated with native and non-native vegetation. Arthropods were collected in each habitat using pitfall traps. Differences in arthropod richness were compared using rarefaction curves. Non-metric multidimensional scaling, and non-parametric multivariate statistical procedures including …
Music And The Modern Maya: A Reception Study Of Rock-Maya Music In Guatemala, Malcolm Miguel Botto
Music And The Modern Maya: A Reception Study Of Rock-Maya Music In Guatemala, Malcolm Miguel Botto
Theses and Dissertations
The current global flows of people, capital, technology, images and ideas--a phenomenon described as "mediascapes" by Arjun Appadurai (1996), traverse the most isolated Maya communities in Guatemala. These flows have recently influenced the creation of hybrid media products among the Maya. Among them we find an emerging indigenous musical genre called "Rock-Maya." I use reception analysis methods to document the encoding and decoding of this new indigenous medium of communication. Through qualitative interviews I attempt to show how K'iche'-Maya youth appropriate, what Motti Regev (1997) calls, the rock aesthetic to promote a sense of K'iche'-Maya youth identity in a modern …
Investigating And Modeling Possible Mechanisms By Which Healthy Cell Membranes Become Resistant To Hydrolysis By Secretory Phospholipase A2, Jennifer Nelson
Investigating And Modeling Possible Mechanisms By Which Healthy Cell Membranes Become Resistant To Hydrolysis By Secretory Phospholipase A2, Jennifer Nelson
Theses and Dissertations
Secretory phospholipase A2 (sPLA2) behaves differently toward the membranes of healthy cells compared to those of damaged or dying cells. The enzyme catalyzes rapid and sustained hydrolysis of compromised cells consistent with a simple catalytic mechanism. In contrast, when healthy cells are incubated with sPLA2, they become resistant to hydrolytic attack as manifest by three unusual observations: First, hydrolysis is transient and represents only a small fraction of the total membrane phospholipid content. Second, subsequent addition of sPLA2 fails to generate additional product. Third, the apparent potency of the enzyme to cause the membrane to be refractory is much greater …
Evaluation Of Downy Mildew (Peronospora Farinosa F.Sp. Chenopodii) Resistance Among Quinoa Genotypes And Investigation Of P. Farinosa Growth Using Scanning Electron Microscopy, Leilani Kitz
Theses and Dissertations
Quinoa (Chenopodium quinoa Willd.) is a pseudocereal native to the Andean region of South America and a staple crop for subsistence farmers in the altiplano of Bolivia and Peru. Downy mildew is the most significant disease of quinoa caused by the pathogen Peronospora farinosa f.sp. chenopodii Byford. This disease greatly impacts quinoa crops with yield losses up to 99%. As fungicides are expensive for farmers, the development of resistant cultivars appears to be the most efficient means for controlling downy mildew. The quinoa germplasm bank contains high amounts of genetic diversity, some of which exhibit mildew resistance. Methods for evaluating …
A Comparative Analysis Of Hydrolysis Kinetics By Spla2 Isoforms During Apoptosis In S49 Cells, Erin Dalene Olson
A Comparative Analysis Of Hydrolysis Kinetics By Spla2 Isoforms During Apoptosis In S49 Cells, Erin Dalene Olson
Theses and Dissertations
Secretory Phospholipase A2 (sPLA2) represents a diverse class of roughly 20 enzymes, 12 of which have been identified in humans. These isoforms can be distinguished based on their tissue distribution, structure, and regulation. These differences in structure between the isoforms lead to the question does the enzyme's ability to respond to physical changes in the membrane during apoptosis governed by structure. S49 cell apoptosis was initiated by treatment with either the glucocorticoid dexamethasone (6–48 h) or with the calcium ionophore, ionomycin. The rates of hydrolysis were compared with each treatment condition for various concentrations of snake venom and human groups …
Studies On Transformation Of Tomato(Solanum Lycopersicum L.) And Arabidopsis Thaliana Using Chimerical Constructs Of Varying Tospoviral Origin, Joshua Nathaniel Cobb
Studies On Transformation Of Tomato(Solanum Lycopersicum L.) And Arabidopsis Thaliana Using Chimerical Constructs Of Varying Tospoviral Origin, Joshua Nathaniel Cobb
Theses and Dissertations
Pathogen derived resistance (PDR) is a recent breakthrough where plant hosts can be made to be resistant to viral infections through transformation with conserved viral genes. Given the severity of Tospovirus diseases worldwide (particularly in tomato), PDR has the potential to garner large yield returns where pathogen populations have overcome the established resistance. Tomato breeding lines FLA7804, FLA8044, and the research line MP1 were used in transformation experiments with potions of the Tomato spotted wilt virus (TSWV) N-gene, and two other chimerical viral nucleocapsid gene constructs from, Impatiens necrotic spot virus (INSV), and Groundnut ringspot virus (GRSV). We conducted 19 …
Religious Networks As A Sociolinguistic Factor: The Case Of Cardston, Benjamin Joseph Chatterton
Religious Networks As A Sociolinguistic Factor: The Case Of Cardston, Benjamin Joseph Chatterton
Theses and Dissertations
Religious affiliation and its inherent membership in an associated social network as a sociolinguistic factor is examined in the community of Latter-day Saints (LDS) in Cardston, Alberta. Building on Meechan's 1998 findings that the LDS community in the area used Canadian Raising in a different set of phonotactic environments than the surrounding non-LDS English speakers, the study aims to determine if the LDS community uses other Canadian speech features differently or less frequently and if any Utah features (defined as Utah English in the literature, being the language of LDS English speakers in Utah) have continued from the settling of …