Digital Commons Network^™

Information Geometric Approaches To Optimal Experimental Design And Reduced-Order Modeling In Ocean Acoustics, Jay C. Spendlove

Theses and Dissertations

This thesis demonstrates the application of information geometry to problems in underwater acoustics. Information geometry combines the fields of information theory and differential geometry by interpreting a multiparameter model as a Riemannian manifold in an ambient data space. Information geometry tools are especially powerful in context of problems of experimental design and model selection in ocean acoustics. The application area specifically considered in this research is geoacoustic inversion, where seabed parameter values are inferred from acoustical data. Chapter 2 contains a paper submitted to the Journal of Theoretical and Computational Acoustics, which introduces information geometry tools such as the model …

Sex Influences Of Age Of Onset And Duration Of Illness On Patterns Of Cortical Thickness In Individuals With Schizophrenia, Rachael Olivia Slate

Theses and Dissertations

Given that the manifestation of schizophrenia varies by sex, it is hypothesized that the interaction between diagnosis and sex significantly influences brain structure and is believed to be a crucial factor in understanding the neurobiology of schizophrenia. While much is known about cortical thickness mapping of the condition, there is currently no work that has assessed how changes to the cortical mantle relate to important clinical features of schizophrenia that vary by sex, such as age of illness onset (AOO) or duration of illness (DOI). This study utilized a sex-wise approach to examining cortical thickness alterations in men and women …

Effect Of Local Chain Stiffness On Oligomer Crystallization From A Melt, Pierre Kawak, Christopher Akiki, Douglas R. Tree

Faculty Publications

While the process by which a polymer crystal nucleates from the melt has been extensively studied via molecular simulation, differences in polymer models and simulated crystallization conditions have led to seemingly contradictory results. We make steps to resolve this controversy by computing low-temperature phase diagrams of oligomer melts using Wang-Landau Monte Carlo simulations. Two qualitatively different crystallization mechanisms are possible depending on the local bending stiffness potential. Polymers with a discrete bending potential crystallize via a single-step mechanism, whereas polymers with a continuous bending potential can crystallize via a two-step mechanism that includes an intermediate nematic phase. Other model differences …

Ready, Set, Grow: From Micelles To Giant Vesicles Via Biocatalytic Activation, Nicholas P. Bair, Qinyu Zhu, Bryon A. Staynings, Douglas R. Tree, Walter F. Paxton

Faculty Publications

Controlling physicochemical processes that drive changes in supramolecular aggregates is an important objective toward creating artificial soft micro- and nanomachines. Previous research explored the morphology control of membrane-based materials subjected to externally imposed chemical stimuli. Here, we modulate the microscale morphology of pH-responsive assemblies by using biocatalysis to internally generate changes in global pH. Catalytic reactions offer flexibility in the mechanism and rate at which stimuli are introduced to responsive assemblies, ultimately enabling precision and control over size and morphology. We observed, by dynamic light scattering and fluorescence microscopy, substantial microscale differences between assemblies subjected to manually titrated pH changes …

Facets Of Neuroticism As Predictors Of Heart Rate Variability And Psychological Distress, Mikel Cressman

Theses and Dissertations

Heart rate variability (HRV) and personality are related to both physical and mental health outcomes. Previous research has found a relationship between neuroticism and distress while the findings on the relationship between neuroticism and HRV are mixed. Studying the facets of neuroticism may provide a more nuanced view of the effects of personality on HRV and distress. Previous research has suggested that the vulnerability facet of neuroticism appears to be uniquely related to the cardiovascular response to stress. This study's first hypothesis is that individuals with higher scores on the vulnerability facet will have lower heart rate variability. The second …

The Role Of Nr4a Transcription Factors In The Body And Their Effects In The Pancreatic Beta Cell, Jacob A. Herring

Theses and Dissertations

A central aspect of type 1 and type 2 diabetes is decreased functional β-cell mass which leads to systemic glucose dysregulation. Functional β-cell mass takes into account β-cell insulin secretion, β-cell proliferation, and β-cell survival. Several treatments are currently used to help maintain glucose levels in individuals with diabetes. However, cures for these diseases are not available due to inability to expand functional β-cell mass. Transcription factors control expression of target genes critical for various functions, and transcription factors that control β-cell function, proliferation and survival play a significant role in β-cell development and function. A more thorough examination of …

Women Gaze Back: Affect And Apparatic Disintegration In Funeral Parade Of Roses And Perfect Blue, Jessi Ivie

Theses and Dissertations

This thesis explores how films Funeral Parade of Roses (1969) by Toshio Matsumoto and Perfect Blue (1997) by Satoshi Kon subvert the male gaze of the camera by having the female main characters look back at the audience. The characters Mima (Perfect Blue) and Eddie (Funeral Parade) take control of the camera to subvert the hierarchical relationship between apparatus, audience, and characters. Through the lenses of apparatus and affect theory, these films show how the world of film includes the audience instead of precluding them. Experimental editing and heightened emotional situations unsettle the audience's voyeuristic position, bringing them closer to …

Jinetes De La Tormenta: The Invasive Influence Of Gender Constructs On The Journey Towards Selfhood And Societal Progress, Marissa Nicole Luquette

Theses and Dissertations

The novel Jinetes de la tormenta, written by Spanish author, Javier Castañeda de la Torre, presents gender as an obstacle to individuals in the ongoing process of self-discovery (as it relates to personal identity) and as the underlying source of human discontent in the technological age. Jinetes represents gender as a hindrance to the developing self through masculine and feminine binaries in European colonial languages and through the performative behavioral expectations tethered to the gendered body the theoretical works of Jacques Lacan and Hélène Cixous. The theoretical works of Jacques Lacan and Hélène Cixous establish the argument surrounding linguistic gender …

Evaluating The Effects Of Cheatgrass On Western Burrowing Owls, Kaylee R. Draughon

Theses and Dissertations

There has been a global decline of specialist species observed in recent decades due to the impacts of climate change, invasive species, and habitat loss. Habitat loss and degradation may lead to a mismatch between habitat attractiveness and actual quality, otherwise known as an ecological trap. Ecological traps occur when an organism is constrained by its evolutionary past to select for cues that no longer accurately predict habitat quality. Specialist species are more susceptible to ecological traps due to greater reliance on and fidelity to historic sites and resources. The burrowing owl (Athene cunicularia), a specialist bird species adapted to …

Exploring Seizure Signal Processing And Methods To Characterize Seizure-Like Activity In Mouse Brains, Benjamin Kearsley

Undergraduate Honors Theses

Status Epilepticus (SE) is a dangerous type of seizure that is difficult to treat and can have permanent or fatal consequences. Developing methods to properly process and classify SE in Local Field Potential (LFP) signals are important steps towards being able to predict SE in clinic and save lives. This thesis explores methods for the seizure data processing LFP data with the goal of gaining a deeper understanding of the effect of brain region and tissue preparation paradigm on power output in specific frequency ranges. The brain regions compared are the neocortex and hippocampus, and the preparation paradigms are 4AP …

Synthesis Of Streptococcus Pneumoniae Serotypes 6a And 6b Di- And Trisaccharides As Propargyl Glycosyl Antigens For Glycoconjugate Vaccines, Tianyao Meng

Theses and Dissertations

Streptococcus pneumoniae (Spn) is a globally prevalent Gram-positive pathogen responsible for invasive pneumococcal diseases (IPD). Among its over 90 serotypes, Spn serotypes 6A (Sp6A) and 6B (Sp6B) are two of the most common causes of IPD around the world and are more frequently isolated from infections than most of the other serotypes. Our group has previously developed a method for making immune responses to bacterial glycans T cell-dependent, involving attachment of short synthetic glycans to a virus-like nanoparticle (VLP), and in combination with a natural killer T cell (NKT cell) adjuvant. This strategy enhanced immune responses by facilitating T cell …

Comparative Genomics Of Anax (Odonata: Aeshnidae), Ying Fei Lin

Theses and Dissertations

Insect migration is an important phenomenon characterized by the long-distance travel of various species in search of resources, safety, breeding, and/or suitable climates. However, relatively little is known about insect migration patterns and the genetic factors associated with them. Three closely related species of dragonflies (Odonata: Aeshnidae), Anax junius, A. strenuus, and A. walsinghami, form a clade of migratory and non-migratory species and present a natural laboratory to study the evolution of genes that may be related to muscle developments and insect migration. In this study, we sequence the whole genomes of these three Anax species to present a resource …

The Osteological Neutral Pose Of The Neck Of An Apatosaurine Sauropod Based On Virtual And Physical Models, Colin Don Boisvert

Theses and Dissertations

An array of sauropod taxa coexisted in Late Jurassic North America. How so many giant genera coexisted without competing for food is puzzling considering their potential metabolic requirements. One aspect of this question is neck posture, which has been much contested, both in terms of the intrinsic curvature of the neck and the resultant elevation of the head. Neck curvature is characterized by the Osteological Neutral Pose (ONP), wherein the intervertebral joints are in an undeflected state. This pose is crucial to understanding neck posture. The articulated series of presacral vertebrae 2-19 of an exceptionally well-preserved apatosaurine, BYU 18531, are …

Chromosome-Scale Assemblies And A Pangenome Reveal Ltr Repeat Dynamics As A Major Driver Of Genome Evolution In Chenopodium, Kate E. Jaggi

Theses and Dissertations

The genus Chenopodium, which comprises around 150 species globally, is characterized by its wide geographic distribution and ecological adaptability, particularly in temperate regions. Some species, such as Chenopodium quinoa and Chenopodium pallidicaule, have served as domesticated staple crops in the Andean region of South America for centuries, valued for their robust nutritional profile and adaptability to adverse environmental conditions. In contrast, wild Chenopodium species exhibit broad geographic distributions and diverse niche adaptations, functioning as reservoirs for beneficial traits, including disease resistance and climate hardiness, essential for enhancing domesticated crops through introgression and breeding efforts. However, taxonomic classification within the genus …

A Grounded Theory Analysis Of Honesty And Deception In Intimate Relationships, Lyndsey Kunzler Gerring

Theses and Dissertations

Although honesty is valued in intimate relationships, there has not been significant research on the range and different types of honesty and deception and their impacts on couples. The purpose of this study was to explore and define the role honesty plays in intimate relationships by examining the spectrum of honest and deceptive behaviors as described by participants. The study utilized qualitative methods to examine how romantic partners describe various types of honesty and deception in their relationships and the influence these have. The data was taken from part of a larger project on healthy and unhealthy relationships where semi-structured …

Ocean Rain Detection And Wind Retrieval Through Deep Learning Architectures On Advanced Scatterometer Data, Matthew Yoshinori Otani Mckinney

Theses and Dissertations

The Advanced Scatterometer (ASCAT) is a satellite-based remote sensing instrument designed for measuring wind speed and direction over the Earth's oceans. This thesis aims to expand and improve the capabilities of ASCAT by adding rain detection and advancing wind retrieval. Additionally, this expansion to ASCAT serves as evidence of Artificial Intelligence (AI) techniques learning both novel and traditional methods in remote sensing. I apply semantic segmentation to ASCAT measurements to detect rain over the oceans, enhancing capabilities to monitor global precipitation. I use two common neural network architectures and train them on measurements from the Tropical Rainfall Measuring Mission (TRMM) …

Self-Determination Towards Regular Exercise Relates To Quality Of Life In Female College Students With At Least One Child, Toby Khung Chilai Roylance

Theses and Dissertations

Inspired by one of my daughters, Rachel Tam, and her journeys through motherhood while pursuing an MBA at Brigham Young University, this study was conceived from observing her struggle to balance academic responsibilities, motherhood, being a wife, and prenatal care. Her experience highlighted the significance of self-directed physical activity (PA) for young mothers pursuing higher education in a religious institution. This study explores the dynamics of PA, motivation, and well-being among 264 college-attending mothers from Brigham Young University Provo and BYU-Pathway Worldwide. These participants were selected from an online survey pool of over 1,500 female student respondents. All mothers in …

Chemical Herding As A Multiplicative Factor For Top-Down Manipulation Of Colloids, Mark N. Mcdonald, Douglas R. Tree, Cameron K. Peterson

Faculty Publications

Colloidal particles can create reconfigurable nanomaterials, with applications such as color-changing, self-repairing, and self-regulating materials and reconfigurable drug delivery systems. However, top-down methods for manipulating colloids are limited in the scale they can control. We consider here a new method for using chemical reactions to multiply the effects of existing top-down colloidal manipulation methods to arrange large numbers of colloids with single-particle precision, which we refer to as chemical herding. Using simulation-based methods, we show that if a set of chemically active colloids (herders) can be steered using external forces (i.e., electrophoretic, dielectrophoretic, magnetic, or optical forces), then a larger …

Differential Effects Of Social Media On Body Esteem: An Ecological Momentary Assessment On Weight Satisfaction And Muscularity Importance, Megan Van Alfen Brown

Theses and Dissertations

This study investigated how social media use is related to body esteem (particularly weight satisfaction and muscularity importance) in adolescents. We conducted a 17-day Ecological Momentary Assessment study among 183 adolescents (12–17 years, 58% girls). Each adolescent reported on his/her social media use, weight satisfaction, and muscularity importance four times per day (68 assessments per participant; 6,863 completed in total). Using a person-specific, N=1 method of analysis (Dynamic Structural Equation Modeling), we found that at the between-person level, social media use is not associated with lower satisfaction with one’s weight and greater importance of looking masculine. At the within-person level, …

Design And Fabrication Of Passive Microfluidic Devices For Enhancing Membrane-Based Biosensors, Tanner N. Wells

Theses and Dissertations

Microfluidic devices and systems have demonstrated wide applicability in sample processing and analysis. The ability to integrate sample processing and analysis into a single platform is a key benefit of microfluidic technologies. This dissertation describes the design and fabrication two types of microfluidic devices developed to enhance membrane-based biosensors. First is a device for collecting particles into a highly confined region, locally enhancing their concentration. Second is a device for size-based particle separation capable of separating differently sized particles into separate streams. Both types of devices are fabricated with a thin top layer, providing a platform for synthetic membrane-based technologies. …

The Design, Prototyping, And Validation Of A New Wearable Sensor System For Monitoring Lumbar Spinal Motion In Daily Activities, Brianna Bischoff

Theses and Dissertations

Lower back pain is a widespread problem affecting millions worldwide, because understanding its development and effective treatment remains challenging. Current treatment success is often evaluated using patient-reported outcomes, which tend to be qualitative and subjective in nature, making objective success measurement difficult. Wearable sensors can provide quantitative measurements, thereby helping physicians improve care for countless individuals around the world. These sensors also have the potential to provide longitudinal data on daily motion patterns, aiding in monitoring the progress of treatment plans for lower back pain. In this work it was hypothesized that a new wearable sensor garment that makes use …

Manipulating Colloidal Particles Using Chemical Gradients And Top-Down Control, Mark Nichols Mcdonald

Theses and Dissertations

Colloidal particles provide the ideal building blocks for the next generation of microdevices, such as advanced sensors and precision drug delivery systems. However, many such applications require the use of top-down (i.e. humanly controllable) forces to manipulate colloidal particles with single-particle precision, and current methods can only achieve such precision for small numbers of particles at a time. To address this challenge, we propose using chemical forces in combination with existing top-down techniques to enable the control of larger numbers of particles simultaneously. Controlling colloids using chemical reactions is a novel technique not typically utilized. Due to its distinct difference …

Factors Surrounding Mental Health Well-Being For Male Adolescent Pacific Islanders, Melia Fonoimoana Garrett

Theses and Dissertations

Despite increasing mental health concerns, individuals from the Pacific Islands largely do not utilize the resources available to them (National Survey of Drug Use and Health, 2020). This is of particular concern among male adolescents within the population who are more at risk of mental health concerns. An interpretative phenomenological analysis focus group study was conducted in person with male adolescent Pacific Islanders (PI; ages 14–16) residing in one Western state (n = 3). Male adolescents reported that admitting to mental health concerns would greatly limit their academic, career, and personal ambitions due to the stigma attached. They also discussed …

Leveraging Biological Mechanisms In Machine Learning, Kyle J. Rogers

Theses and Dissertations

This thesis integrates biologically-inspired mechanisms into machine learning to develop novel tuning algorithms, gradient abstractions for depth-wise parallelism, and an original bias neuron design. We introduce neuromodulatory tuning, which uses neurotransmitter-inspired bias adjustments to enhance transfer learning in spiking and non-spiking neural networks, significantly reducing parameter usage while maintaining performance. Additionally, we propose a novel approach that decouples the backward pass of backpropagation using layer abstractions, inspired by feedback loops in biological systems, enabling depth-wise training parallelization. We further extend neuromodulatory tuning by designing spiking bias neurons that mimic dopamine neuron mechanisms, leading to the development of volumetric tuning. This …

Reactivity To Environmental And Social Demands In Autistic And Neurotypical Adults: More Alike Than Different?, Mackenzie Marjorie Hyde

Theses and Dissertations

Lack of mutual understanding between autistic and neurotypical individuals contributes to the marginalization of the autistic community. This study aimed to investigate similarities in reactivity to environmental and social pressures between autistic and neurotypical adults in order to facility empathy between the communities. Participants were 328 young adults aged 18-26 years old. Twenty-eight young adults (14 female) reported a diagnosis of autism spectrum disorder (ASD) and 300 young adults (150 female) comprised a complimentary group of neurotypical individuals. Participants completed multiple standardized tests to measure autistic trait expression and an original survey that measured their reactivity to eight scenarios that …

Challenging The Master Narrative Of Holocaust Victimhood: Examining The Holocaust Through A Gendered Lens, Annabella Blowers

Undergraduate Honors Theses

Women are severely unrepresented in the master narrative that has come to define what it means to be a Holocaust victim. Although men and women were subjected to different forms of victimization, women’s unique experiences of suffering have been marginalized and subsumed within the male-dominated master narrative. Examining the Holocaust through a gendered lens challenges this existing narrative of Holocaust victimhood. Conducting a gender analysis of the Holocaust is essential to fully incorporate women’s experiences into Holocaust history and the grossly inadequate narrative society uses to define Holocaust victimhood.

An analysis of fifty Holocaust fiction novels revealed that literature’s depiction …

Medial Temporal Lobe Surface Features And Cognition In Aging Amyloid-Positive Individuals, Jacob Johnston

Undergraduate Honors Theses

Memory consolidation and metabolism are known to differ between amyloid-beta plaque positive (A+) and negative (A-) amnestic Mild Cognitive Impairment (aMCI) and Alzheimer's disease (AD) dementia participants despite similar medial temporal lobe (MTL) volume between groups. Using high-dimensional surface analysis (shape characterization), this study identified structural differences in the medial temporal lobe between A+ aMCI, A+ AD dementia, and amyloid-negative (A-) healthy control groups (CON), specifically in the CA1 and subiculum regions of the hippocampus and entorhinal cortex. Additionally, regional brain surface-based features were correlated with procedural and episodic memory measures, finding positive associations between CA1 integrity and episodic memory …

One Size Does Not Fit All: Creating Educational Equity For Later Diagnosed Autistic Women, Naomi Julian

Undergraduate Honors Theses

Autism research focuses on the externalized behaviors usually associated with the male phenotype of autism with little representation of the internalized behaviors associated with the female phenotype of autism. Even more so, there is little research involving later diagnosed autistic women — especially women of color. Beyond this, non-white individuals have been marginalized within the sphere of education, and their marginalization is exacerbated by an autism diagnosis.

In the realm of schooling, the relationship between race, gender, and disability lacks investigation. In this exploratory study, I draw upon qualitative data from interviews of 17 racially diverse autistic women ages ranging …

Investigation Of Collision Cross Sections & Time-Resolved Structural Modification Of Biomolecules, Host-Guest Systems, & Small Molecules Using Ion Mobility & Fourier Transform Ion Cyclotron Resonance Mass Spectrometry, Noah Mismash

Theses and Dissertations

This thesis explores the structures and structural changes of supramolecular host-guest systems, proteins, and other small molecules in the gas phase, utilizing a combination of computational modeling and experimental data. The primary instruments employed were a Fourier transform ion cyclotron resonance mass spectrometer (FTICR-MS) and an ion mobility mass spectrometer (IM-MS). In the IM-MS experiments, the focus was on investigating the binding behavior of cyclodextrin macrocycles—specifically α, β, and γ-cyclodextrin—with per-fluoroalkane substances (PFAS), which are pervasive environmental contaminants. This investigation involved measuring ion-neutral collision cross sections and using computational modeling to determine whether PFAS compounds bind inside or outside the …

Mathematical Modeling And Understanding The Physiological Mechanisms Of Vibration On Wound Healing And Scar Remodeling, Devin Rion Needs

Theses and Dissertations

Chronic wounds and pathological scars reduce the quality of life for millions of people worldwide. Through mathematical modeling and clinical testing, understanding of how these conditions occur continues to increase. These tools have also been employed to investigate the efficacy of treatments that could impact wound healing and scar remodeling. The purpose of this work is to investigate the physiological effects of vibration treatment on wound healing, blood flow, and scar remodeling through mathematical modeling and experimental testing. This work presents and validates a mathematical murine model for whole body vibration enhanced wound healing (VEWH). This VEWH model builds on …