Digital Commons Network^™

Sound Innovations For Biofabrication And Tissue Engineering, Mengxi Wu, Zhiteng Ma, Zhenhua Tian, Joseph Rich, Xin He, Jianping Xia, Ye He, Kaichun Yang, Shujie Yang, Kam W. Leong, Luke P. Lee, Tony Jun Huang

Faculty Publications

Advanced biofabrication techniques can create tissue-like constructs that can be applied for reconstructive surgery or as in vitro three-dimensional (3D) models for disease modeling and drug screening. While various biofabrication techniques have recently been widely reviewed in the literature, acoustics-based technologies still need to be explored. The rapidly increasing number of publications in the past two decades exploring the application of acoustic technologies highlights the tremendous potential of these technologies. In this review, we contend that acoustics-based methods can address many limitations inherent in other biofabrication techniques due to their unique advantages: noncontact manipulation, biocompatibility, deep tissue penetrability, versatility, precision …

Investigating Secondary Metabolites Of Streptomyces And Bacillus Bacteria That Inhibit Colony Growth Of Pathogenic Potato Fungi (Colletotrichum Coccodes, Pythium Ultimum), Jacob R. Henrie

Theses and Dissertations

Potato (Solanum tuberosum) is a crucial global food crop, yet its production is threatened by fungal pathogens such as Pythium ultimum and Colletotrichum coccodes, which cause significant yield losses and impact tuber quality. In this study, we investigated the antifungal properties of various Streptomyces and Bacillus isolates against these pathogens. The Streptomyces isolates, known for their prolific secondary metabolite production, were selected for their varying efficacy against these fungi. Despite the anticipated potential, Streptomyces isolates exhibited limited antifungal activity against Pythium ultimum and only moderate activity against Colletotrichum coccodes. In contrast, Bacillus isolates, particularly B1, demonstrated strong inhibition of C. …

Biodegradable Polymeric Microspheres For Magnetically Guided Drug Delivery To Tumors, Tyler Payson Green

Theses and Dissertations

This thesis investigates the feasibility of utilizing biodegradable polymeric microspheres loaded with the anticancer drug 5-fluorouracil (5FU) and superparamagnetic iron oxide nanoparticles (SPIONs) to magnetically deliver the cancer therapeutic 5FU to a target tumor in the human body. The primary method of material loading consisted of a w/o/w double emulsion mechanism which 1) loads and protects 5FU in the inner water phase consisting of distilled water and polyvinyl alcohol (PVA), 2) dispersed SPIONs in the biodegradable polymeric organic phase consisting of methylene chloride (MeCl2) for eventual magnetic transport, and 3) suspended these w/o emulsion droplets in an outer aqueous phase …

Ballard Brief, Kate Bradley, Jayden Davis

Marriott Student Review

At Ballard Brief, we help people understand the problem by publishing topic-specific briefs that synthesize modern research about social issues. Ballard Briefs are authored by BYU students who noticed a problem and set out to educate themselves and others.

Review: White Before Whiteness In The Late Middle Ages, Alani Hicks-Bartlett

Quidditas

No abstract provided.

End-Of-Life Care For Hispanics In The United States, Rebecca Zarate

Family Perspectives

No abstract provided.

Automation, Improvement, And Sensitivity Analysis Of 3d Parameterized Maize Stalk Models, Joseph Steven Carter

Theses and Dissertations

Maize is the most grown crop in the world. Each year, 5% of maize is lost due to a phenomenon known as stalk lodging (breakage of the stalk below the ear). One of the most promising solutions to stalk lodging is to design stalks with superior geometry to increase stalk strength. Researchers have developed a 3D parameterized maize stalk model, but these models take a long time to structurally analyze and are missing important material properties. This thesis addressed these problems by developing an automated package for analyzing the 3D parameterized maize stalk model, and by measuring the longitudinal shear …

Embodiment And Ritual Clothing: Dressing The Israelite High Priest, Ally Huffmire

Studia Antiqua

Exodus 28 and 39 contain a detailed description of the clothing God instructed to be made and worn by Israelite priests. In this essay, sacred clothing will be understood through the lens of ritual studies, characterizing clothing with a sense of liminality that defines and endows the human wearer with identity and power. The social meanings and implications of the high priest’s dress will be reconstructed by engaging in sensory criticism, drawing upon insights from the greater eastern Mediterranean world. Given the ancient world’s unique conception of a permeable body, ritual clothing had the ability to imbue the wearer with …

Magnetic Resonance Imaging Of Ultrasound Fields For Visualization And Measurement Of Pressure Amplitudes, Paul-Emile Victor Passe-Carlus

Theses and Dissertations

In vivo pressure estimations for therapeutic ultrasound has the potential of rendering treatments using non-invasive ultrasound targeting safer and more reliable. By quantifying pressures and their respective spatial locations, better acoustic predictions and models can be made. In this thesis, we aim to measure a pressure field from a piezo-electric transducer through a ballistic gel medium by using an external gradient coil to encode the pressure field in a way that can be read and quantified using an MRI scanner. We describe the methods and the results pertaining to visualizing a pressure field. The setup was able to capture pressure …

Development Of Temperature Measurement And Control Of 3d Printed Microfluidic Devices Towards Biomolecular Analysis, Derek A. Sanchez

Theses and Dissertations

Microfluidics are devices with channels or reservoirs that have dimensions in the range of micrometers. They have an increasing role in biological analysis processes due to their ability to use very small sample volumes. Many microfluidic processes rely heavily on precise temperature measurement and control. Advances in 3D printing have led to high resolution digital light processing stereolithography (DLP-SLA) printers capable of using bio-compatible materials, available at BYU. This custom 3D printer has a resolution of 7.6 µm in the XY plane and 10 µm in the Z axis. Combined with a custom-made resin, we can produce microfluidic features as …

Joint Subarray Acoustic Tweezers Enable Controllable Cell Translation, Rotation, And Deformation, Liang Shen, Zhenhua Tian, Kaichun Yang, Joseph Rich, Jianping Xia, Neil Upreti, Jinxin Zhang, Chuyi Chen, Nanjing Hao, Zhichao Pei, Tony Jun Huang

Faculty Publications

Contactless microscale tweezers are highly effective tools for manipulating, patterning, and assembling bioparticles. However, current tweezers are limited in their ability to comprehensively manipulate bioparticles, providing only partial control over the six fundamental motions (three translational and three rotational motions). This study presents a joint subarray acoustic tweezers platform that leverages acoustic radiation force and viscous torque to control the six fundamental motions of single bioparticles. This breakthrough is significant as our manipulation mechanism allows for controlling the three translational and three rotational motions of single cells, as well as enabling complex manipulation that combines controlled translational and rotational motions. …

Viewing Adhd’S Impact On Children’S Social Development Through The Lens Of Peer Rejection, Bethany Sycamore

Family Perspectives

No abstract provided.

50 Universities Working On Research In Public Health Technologies, Angie Holzer, Erica Bassett

Journal of Nonprofit Innovation

No abstract provided.

Covid-19 And Health Equity: Lessons Learned From The Pandemic, Sumaya Ali, Lakell Archer, Erica L. Jensen

Journal of Nonprofit Innovation

Health inequities refer to avoidable, unjust differences in health outcomes caused by systemic disadvantages rooted in social, economic, and environmental contexts (Braveman, 2014). Health disparities refer to differences in health outcomes between groups, often measured by prevalence, morbidity, or mortality (Centers for Disease Control and Prevention [CDC], 2020). Health inequalities are measurable differences in health status that may arise from biological, social, or environmental factors (World Health Organization [WHO], 2019). Health inequities, however, are specifically preventable and unjust differences.

The COVID-19 pandemic highlighted these inequities, intensifying pre-existing structural disparities within healthcare and societal systems. The pandemic underscored the urgency of …

Addressing Adolescent Suicide In South Korea, Alyssa Kang

Journal of Nonprofit Innovation

Suicide is a prevalent issue that widely affects all demographics in South Korea. Among adolescents, it is the leading cause of mortality with an average rate of 7 deaths per 100,000 people. Some of the most significant factors that influence the risk of suicidal ideation and attempts are cultural stigma and academic stress. Other factors, such as bullying and family structure, also increase the likelihood of suicide, while specific characteristics including internet addiction, socioeconomic status, and substance abuse have been found to be predictors of suicide. Adolescent suicide attempts in Korea also increase the individual's risk for future attempts, and …

Cognosis And The Evolution Of Civilization, Ken Baskin

Comparative Civilizations Review

From the time when the complex states such as Egypt or Sumer emerged roughly 5,000 years ago, the civilizations they represent have generally become more populous, more socially varied, wealthier, and more technologically advanced. As a result, the innovations they produced would begin to change the conditions in which they existed, and their cultures have had to evolve to adapt to this ongoing change. For instance, the cultures of Bronze Age Egypt and the Iron Age Han Dynasty had to be quite different, even though both were agricultural societies. And, of course, the Electronic Age cultures of the United States …

Seventeen Crises In Western Civilization That Have Arisen Since The Dark Ages: A Cognition Science-Oriented Approach, Andrew Targowski

Comparative Civilizations Review

The purpose of this article is to synthesize those crises in the unfolding of Western civilization that are controlled by human knowledge and wisdom. The methodology is transdisciplinary, utilizing a cognitive science-oriented, big-picture view of civilization and main conflicts. The crises are investigated across three time periods; the Dark Ages (from the fifth to the fourteenth century), Modern Times (from the fifteenth to the twentieth century), and the present century. The findings reveal that today Western civilization faces seventeen significant crises. Knowledge is not sufficient to solve these crises; we need to employ knowledge-based wisdom. This approach presents a new …

The Sociology Of Crisis: Pitirim Sorokin’S Scholarly Legacy And Current Problems, Resilience, And Community, Emiliana Mangone

Comparative Civilizations Review

In his writings on crises, Sorokin highlighted their complexity and their multiple consequences on a personal, cultural, and social level. In this paper, crises in the 21st century are analyzed from Sorokin’s incisive perspective. The significant points include:

1. the study of crises cannot be enclosed within the confines of individual disciplines but rather must incorporate interdisciplinary approaches.
2. the category “crisis” does not encompass only those conditions that are the consequences of specific disastrous events such as natural disasters, wars, and terrorism but also all those phenomena that produce the conjunction of harm to human beings and social disturbances.
3. successive crises …

The Geographic Clash Of Civilizations?, Mojtaba Sadeghi

Comparative Civilizations Review

The Geographic Clash of Civilizations represents a significant geographic-civilizational reality and process, a phenomenon that has occurred and is expected to unfold increasingly in the third millennium. Understanding, analyzing, and forecasting this phenomenon relies solely on the geographic conceptualization of civilization. Through that perspective, the world is undergoing another instance of the geographic clash of civilizations, a clash more profound than the Clash of Civilizations, impacting the survival or collapse of human civilizations. The geographic clash of civilizations epitomizes an inescapable conflict between the soul (das-man) and the body (no-da-sein) of a civilization, stemming from …

Book Review: Why War?, Stephen T. Satkiewicz

Comparative Civilizations Review

Pay any attention to current events and it seems that war and conflict are everywhere: from the Russian invasion of Ukraine in 2022, to the eruption of conflict in the Middle East in October 2023, to on-going geopolitical tensions in the Pacific over the status of Taiwan. It was only a decade or so ago that many were confidently predicting not only the decline but the outright end of war, as Steven Pinker boldly argued in his The Better Angels of Our Nature: Why Violence Has Declined.

Diversification And Evolution Of Hawaiian Megalagrion Damselflies (Pinapinao, Odonata: Coenagrionidae), Robert K. Hadfield

Theses and Dissertations

The Megalagrion damselflies of HawaiÊ»i present a valuable study system for understanding the impacts of geology on evolutionary processes. Despite their significance, our understanding of the temporal, geographic, and phylogenetic origins of these damselflies remains incomplete. Prior phylogenetic studies have proposed adaptive ecological and morphological progressions, but evaluating these hypotheses relies on a sound understanding of phylogenetic relationships within the genus. Previous phylogenetic analyses have produced conflicting topologies. To resolve these uncertainties, we performed phylogenetic analyses including divergence time estimation with 90 nuclear loci (>50 kbp) and 2 mitochondrial loci (>1000 bp), sampling representatives from each genus within …

A Comprehensive Review And Meta-Analysis Of Breast Cancer Gene Expression Data: Understanding The Molecular Complexity Of A Silent Epidemic, Ifeanyichukwu O. Nwosu

Theses and Dissertations

Breast cancer is the most frequently diagnosed cancer type and the leading cause of cancer death; it accounts for 23% of total cases and 14% of deaths, with over 2 million new cases diagnosed and 600,000 deaths in 2020. This is a huge public health burden. Traditionally, clinical subtypes of breast cancer are defined based on a patient's immunohistochemistry profile. These profiles are determined by the combined expression status of three receptors: estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. It has also been observed that women of African descent, more commonly present with ER, PR and …

Optimal Limb Regeneration Strategies In Hemigrapsus Sanguineus, Laura S. Fletcher

Theses and Dissertations

Diet quality and energy allocation influence an individual’s life-history traits by determining how much energy is available for processes such as growth and reproduction. One common method of assessing diet quality involves measuring gut length or size, which is typically inversely related to diet quality. However, this often requires animal sacrifice and time- consuming dissections. Similarly, many traditional bioenergetics models fail to capture the context-dependence of energy allocation, as these models rely on fixed energy allocation rules. One such rule is the κ-rule of dynamic energy budget theory, which assumes a fixed proportion (κ) of assimilated energy is always allocated …

Microbial Hydrolysis Process To Improve Anaerobic Digestion For Biofuel Generation, Caleb Michael Jensen

Theses and Dissertations

Human development results in billions of tons of waste per year, which contributes to major issues such as pollution, climate change, and habitat destruction. In this study, we explored the impact of bacterial inoculation on volatile fatty acid (VFA) production, volatile solids (VS), and gas output in anaerobic digesters under different substrate treatments. Our results reveal that bacterial inoculation significantly boosts VFA levels, especially acetic acid, with both Caldicellulosiruptor bescii and mixed Caldicellulosiruptor, cultures showing notable differences compared to controls, especially in untreated manure and WAS treatments. Acetic acid and VS/TS increased in untreated WAS when inoculated with C. bescii …

Deep Learning For Source Localization In A Laboratory Tank, Corey Emerson Dobbs

Theses and Dissertations

Deep learning has been applied to underwater acoustics problems in many forms. One difficulty in applying deep learning techniques to ocean acoustics is the spatially and temporally varying environmental properties. Another challenge is the lack of labeled data for training large networks. The overall goal of this work is to develop deep learning approaches for source localization that can be adaptable to different conditions. In this work, a convolutional neural network was trained on acoustic data measured in a water tank, while the water was at room temperature, to predict source-receiver range. Tests were done to ascertain ideal quantities of …

Linking Geospatial Trends And Geochemical Fingerprints To Anthropogenic Phosphorus Dust Deposition In Subalpine Soils, Austen Michael Lambert

Theses and Dissertations

This study shows that fugitive emissions associated with the surface mining of phosphate rock are a significant phosphorus (P) source to surface soils in northeastern Utah. Phosphorus is a nonrenewable resource essential for all life. Anthropogenic alterations to the P-cycle have led to widespread P pollution, and the unsustainable management of P has led to the threat of global depletion of P resources. Thus, accounting for both natural and anthropogenic flow paths of P is essential for the conservation and pollution reduction of P. One such source of human alteration to the P-cycle is the mining of phosphate rock. Mining, …

Exploring The Mechanism Of Increased Survival In Rb1-Mutant Glioblastoma Multiforme, Lucia Wesemann

Undergraduate Honors Theses

Glioblastoma Multiforme (GBM) is an incredibly invasive and particularly lethal central nervous system cancer. Recent work has shown that GBM patients with mutated RB1 have greater overall survival. A proposed mechanism for the improved prognosis of this molecular subgroup is mainly supported by previous research that is not specific to GBM. I utilize the Clinical Proteomic Tumor Analysis Consortium (CPTAC) dataset to interrogate this mechanism using GBM-specific data. The mechanism is largely not supported by the CPTAC GBM dataset, and the trend of significantly improved overall survival in RB1-mutant GBM patients is not validated here. This study highlights the …

The Effects Of Combining Β-Lactam Antibiotics And Mefloquine In Multi-Drug Resistant Pseudomonas Aeruginosa, Kayla C. Maas

Theses and Dissertations

Pseudomonas aeruginosa, a notorious opportunistic pathogen, is a leading cause of hospital-acquired infections. The newest generation of β-lactam antibiotics, the carbapenems, are often used to treat multi-drug resistant (MDR) P. aeruginosa infections. Treatment of P. aeruginosa has become increasingly difficult due to its remarkable ability to resist antibiotics through various intrinsic and acquired mechanisms. Physicians rely on a limited group of antibiotics to treat these infections, but many P. aeruginosa isolates are evolving to become resistant to all available antibiotics, including carbapenems. The multifaceted mechanisms underlying P. aeruginosa antibiotic resistance include β -lactamases, efflux pumps, altered membrane porins, and antibiotic …

Tribological Analysis Of Heat Treatments On Medical Grade Cobalt Chromium Molybdenum Alloys, Samuel Edis Bowden

Theses and Dissertations

Cobalt chromium molybdenum (CoCrMo) has many material properties that make it desirable as a medical hip implant. Due to the range of heat treatments available and the resulting material properties that are present in medical device manufacturing using CoCrMo, many implants are not able to withstand both the chemical and physical wear necessary as a hip replacement. This research looks to examine various heat treatments and their resulting properties to find a desirable heat treatment for CoCrMo in hip implant bearing surfaces. This study was accomplished by using five distinct variations of heat treatment on forged CoCrMo alloy that would …

Exploring How Caregiver Multiracial Socialization Is Related To Multiracial Identity Pride, Self-Esteem, And Racial Political Identity In Emerging Adulthood, Jennie Jasperson

Theses and Dissertations

The current study examined how caregiver multiracial socialization processes play a role in multiracial emerging adults' multiracial identity pride self-esteem, and racial political identity. The constructs of caregiver multiracial socialization, multiracial identity pride in emerging adulthood, sense of self-esteem in emerging adulthood, and racial political identity in emerging adulthood were examined among 387 multiracial emerging adults between the ages of 18-29 from across the United States. To examine these relationships, multiple regressions were run to analyze data. The results of this study underscore the significance of understanding the role that socialization processes within multiracial families play in ethnic racial identity …