Digital Commons Network^™

Histone Deacetylase 6 (Hdac6) Is Critical For Tumor Cell Survival And Promotes The Pro-Survival Activity Of 14-3-3Ζ Viadeacetylation Of Lysines Within The14-3-3Ζ Binding Pocket, Jeffrey Benjamin Mortenson

Theses and Dissertations

Our understanding of non-histone acetylation as a means of cellular regulation is in its infancy. Using a mass spectrometry approach we identified acetylated lysine residues and monitored acetylation changes across the proteome as a consequence of metabolic stress (hypoxia). We observed changes in acetylation status of non-histone lysines in tumor cells. Through the use of small molecule inhibitors of histone deacetylase enzymes (HDACs) and siRNA screening identified HDAC6 as a pro-survival regulator of lysine acetylation during hypoxia. The phospho-binding protein 14-3-3ζ acts as a signaling hub controlling a network of interacting partners and oncogenic pathways. We show here that lysines …

Supporting An Understanding Of Mathematics Teacher Educators:Identifying Shared Beliefs And Ways Of Enacting Their Craft, Joseph S. Rino

Theses and Dissertations

For many preservice elementary and secondary teachers, the first time they encounter the notion that mathematics can be taught in ways other than what they experienced is in their teacher preparation program. Therefore, the potential impact of the mathematics teacher educator on the understanding and development of preservice teachers is immense, especially as that impact is considered in connection to the various reform efforts related to mathematics education that have spread across the country for the past three decades. Given the scarcity of systematic research focused on mathematics teacher educators, the author sought to understand defining characteristics of that role. …

Geometry And Material Properties Of Vocal Fold Models, Kimberly Ann Stevens

Theses and Dissertations

Voiced communication plays a fundamental role in society. Voice research seeks to improve understanding of the fundamental physics governing voice production, with the eventual goal of improving methods to diagnose and treat voice disorders. For this thesis, three different aspects of voice production research were studied. First, porcine vocal fold medial surface geometry was determined, and the three-dimensional geometric distortion induced by freezing the larynx, especially in the region of the vocal folds, was quantified. It was found that porcine vocal folds are qualitatively geometrically similar to canine and human vocal folds, as well as commonly used models, and that …

Problems Faced By Reform Oriented Novice Mathematics Teachers Utilizing A Traditional Curriculum, Tyler Joseph Winiecke

Theses and Dissertations

Task-based instruction has been a promising method of instruction advocated by mathematics education researchers over the past twenty years. However traditional curricula constitute a majority of the curricula utilized in the United States. The purpose of this study is to identify the problems reform oriented novice teachers face when utilizing a traditional curriculum to plan task-based lessons. In order to identify these problems three novice teachers' interactions with curricula were observed and characterized using the frameworks of past researchers. Through analysis of teachers' textbook interaction practices it was found that teachers struggled to plan task-based lessons due to issues encountered …

Geologic Mapping Of Ice Cave Peak Quadrangle, Uintah And Duchesne Counties, Utah With Implications From Mapping Laramide Faults, Gabriel J. Poduska

Theses and Dissertations

Geologic mapping (1:24,000 scale) of the Ice Cave Peak quadrangle, Uintah and Duchesne Counties, Utah has produced a better understanding of the geologic structures present in the quadrangle and has increased our understanding of faulting in northeastern Utah. Map units in the quadrangle range in age from late Neoproterozoic to Quaternary and include good exposures of Paleozoic rocks (Mississippian to Permian), limited exposures of Mesozoic rocks, and good exposures of Tertiary strata (Duchesne River Formation and Bishop Conglomerate) deposited during uplift of the Uinta Mountains. Lower Mississippian strata along the south flank of the Uinta Mountains have typically been mapped …

Dna Origami Stabilized And Seeded With 4'-Aminomethyltrioxsalen For Improved Dna Nanowire Fabrication, Matthew Paul Mcdowell

Theses and Dissertations

A fast emerging technology in the microelectronics field is bottom-up self-assembly of computer circuitry. A promising method to develop nanoelectronic devices through bottom-up self-assembly is the implementation of DNA-based technologies. Using DNA to create nanoelectronic devices is advantageous because of its already well understood base-paring and annealing qualities. These base-pairing and annealing qualities can be used to design and construct DNA nanostructures called DNA origami. DNA origami are specially designed structures made from single stranded DNA. Short single stranded DNA oligonucleotides called staple strands attach to a large single stranded DNA called a DNA scaffold. DNA staple strands and DNA …

Progress Towards The Total Synthesis Of Yaku'amide A, Zhiwei Ma

Theses and Dissertations

The synthetic progress towards yaku'amide A is described. The study leads to development of new synthetic methodologies. Base-free regioselective aminohydroxylation is convenient to deliver β-tert-hydroxyamino acids. A sequence consisting of alkylative esterification, Martin sulfurane mediated anti dehydration, a tandem azide reduction-O→N acyl transfer allows the rapid access of E- and Z-dehydroisoleucine-containing peptides from β-tert-hydroxyisoleucine derivatives. Those methods are effective in constructing complicated peptides and advanced subunits of yaku'amide A.

Terminological Mediation In Information Technology And Related Fields, Jessica Smith Richards

Theses and Dissertations

Terminological dissonance is created by the inherent ambiguity of natural language and compounded by ontological specialization efforts within fields. Terminological dissonance creates high-risk miscommunications in two key areas: within Information Technology as a singular domain, and also between IT and other fields in interdisciplinary projects. A comprehensive literature review revealed a lack of previous effort to acknowledge or solve problems of terminological dissonance within Information Technology. This research provides a comprehensive overview and definition of the terminology mediation space as it relates to Information Technology and adjacent fields. An analysis and verification of the contents and implementation of the terminology …

Examining The Effects Of College Algebra On Students' Mathematical Dispositions, Kevin Lee Watson

Theses and Dissertations

As Mathematics Educators, we want to help our students not only develop a deep, conceptual understanding of mathematical concepts and processes, but also a positive disposition towards mathematics. Despite the importance of helping students develop a positive mathematical disposition, little research has been conducted examining how students' dispositions develop as they progress through their mathematical studies. In particular, the effects of college algebra on students' mathematical dispositions is not well understood. To examine the influence of college algebra on students' dispositions, students using two different college algebra curriculums were studied at Brigham Young University. Using a mathematical disposition survey, student …

Including The Arts In The Generalist Classroom, Camille Hone

Theses and Dissertations

Including the Arts in the Generalist Classroom is an integrated arts curriculum within a 6th grade classroom in Eagle Mountain Utah. This project describes the process of putting an art curriculum into an elementary 6th grade where there is no art specialist and no means of getting one. This project focuses on four lessons that have been written using the 6th grade Science and Social Studies Utah Core. Each lesson is written to ensure that a teacher and/or a parent volunteer can give instruction without any prior knowledge of content and/or technique in art.The Appendices describe the curriculum and more …

Use Of Roadway Attributes In Hot Spot Identification And Analysis, David R. Bassett

Theses and Dissertations

The Utah Department of Transportation (UDOT) Traffic and Safety Division continues to advance the safety of roadway sections throughout the state. In an effort to aid UDOT in meeting their goal, the Department of Civil and Environmental Engineering at Brigham Young University (BYU) has worked with the Statistics Department in developing analysis tools for safety. The most recent of these tools has been the development of a hierarchical Bayesian Poisson Mixture Model (PMM) of traffic crashes known as the Utah Crash Prediction Model (UCPM), a hierarchical Bayesian Binomial statistical model known as the Utah Crash Severity Model (UCSM), and a …

Opportunism In Ugandan Ngos: A Randomized Field Experiment, Eric Reuben Smith

Journal of Undergraduate Research

Corruption undermines the effectiveness of international development. The financial integrity of non-governmental organizations (NGO) can be improved by donor-to-organization contact, but foreign donors rarely travel to countries such as Uganda. This project involved a randomized design to compare the size of project bids by NGO management when approached by potential donors (foreigners) or donor representatives (Ugandan citizens). Local donor representatives were more likely to be denied information during an in-person visit than the foreigners visiting NGOs. Otherwise, foreign potential donors were provided with information that was the same as local representatives, except in 6 instances in which bids were substantially …

Discovery And Confirmation Of Novel Serum Biomarkers Diagnosing Alzheimer’S Disease, Tyler Mower, Dr. John Kauwe

Journal of Undergraduate Research

Background: Alzheimer’s disease (AD) remains challenging to diagnose, especially early disease. Useful serum AD biomarkers would be of great utility in clinical settings and in drug development efforts. We used a novel serum proteomic approach to interrogate the lowmolecular- weight proteome for AD biomarkers.

Experimental design: A discovery study used sera from 58 any-stage AD cases and 55 controls analyzed by capillary liquid chromatography-tandem mass spectrometry. Promising biomarkers were retested in a second, blinded confirmatory study (AD cases=68, controls=57). Several biomarkers replicated and multi-marker sets were modeled.

Results: The initial study found 59 potential AD biomarkers. Thirteen recurred in more …

Amiens Cathedral: City Of God, Dennis West, Dr. Seth Holladay

Journal of Undergraduate Research

What was it like to visit a gothic cathedral in the thirteenth century? That is the question that is explored in Amiens Cathedral: City of God. The purpose of this project was to illustrate the experience a medieval citizen of Amiens would have had upon visiting the Cathedral of Amiens. This was accomplished through researching dimensions and original construction of the cathedral, and illustrating how the stained glass and other art accentuates the sermons presented.

Curved-Folding-Inspired Deployable Compliant Rolling-Contact Element (D-Core), Todd Nelson, Robert Lang, Spencer P. Magleby, Larry L. Howell

Faculty Publications

This work describes a deployable compliant rolling-contact element joint (DCORE joint) that employs curved-folding origami techniques to enable transition from a flat to deployed state. These deployable joints can be manufactured from a single sheet of material. Two fundamental configurations of the D-CORE are presented. The first configuration allows for motion similar to that of a Jacob’s ladder when the joint is in a planar state while achieving the motion of a CORE when in the deployed state. The second configuration constrains all degrees of freedom to create a static structure when the joint is in the planar state and …

Alphabetical List Of 106 Swiss Officers With Short Biographical Entries

Swiss American Historical Society Review

No abstract provided.

The Swiss In The American Civil War 1861-1865

Swiss American Historical Society Review

No abstract provided.

A Feasibility Study Of Photometric Reverberation Mapping With Meter-Class Telescopes, Carla June Carroll

Theses and Dissertations

For the past several decades, mass estimates for supermassive black holes hosted by active galactic nuclei (AGN) have been made with the reverberation mapping (RM) technique. This methodology has produced consistent results and has been used to establish several relations that link the characteristics of the host galaxy to the mass of the central black hole. Despite this success, there are less than 50 AGN with black hole masses derived from RM. This low number is generally attributed to the difficulties in coordinating large blocks of telescope time for making simultaneous photometric and spectroscopic observations. Spectroscopic observations also generally require …

Examining The Relationship Between Anemia, Cognitive Function, And Socioeconomic Status In School-Aged Ecuadorian Children, Angela Chamberlain

Theses and Dissertations

Background and Objectives: It is estimated that over 40% of children in Ecuador are anemic. Anemia in children can influence physical and cognitive development and have lasting effects on adulthood productivity and quality of life. The objectives of this study were to: (1) evaluate the relationship of anemia and cognitive function, and (2) determine the influence of demographic factors on cognitive function. Population and Setting: The sample consisted of 175 school-aged children between 5 to 11 years old attending a school in a poverty stricken area of Guayaquil, Ecuador. Methods: A descriptive correlational cross sectional design was used to study …

Meat Intake And Insulin Resistance In Women Without Type 2 Diabetes, Larry A. Tucker, James D. Lecheminant, Bruce W. Bailey

Faculty Publications

Purpose. To examine the relationship between meat intake and insulin resistance (IR) in 292 nondiabetic women. Methods. IR was evaluated using the homeostasis model assessment (HOMA). Diet was assessed via 7-day weighed food records. Servings of very lean meat (VLM) and regular meat (meat) were indexed using the ADA Exchange Lists Program. Physical activity was assessed using accelerometers and body fat was measured using the Bod Pod. Results. Meat intake was directly related to HOMA (F = 7.4; P = 0.007). Women with moderate or high meat intakes had significantly higher HOMA levels than their counterparts. Adjusting for body fat …

Examining The Relationship Between Anemia, Cognitive Function, And Socioeconomic Status In School-Aged Ecuadorian Children, Angela Chamberlain

Student Works

Background and Objectives: It is estimated that over 40% of children in Ecuador are anemic. Anemia in children can influence physical and cognitive development and have lasting effects on adulthood productivity and quality of life. The objectives of this study were to: (1) evaluate the relationship of anemia and cognitive function, and (2) determine the influence of demographic factors on cognitive function. Population and Setting: The sample consisted of 175 school-aged children between 5 to 11 years old attending a school in a poverty stricken area of Guayaquil, Ecuador. Methods: A descriptive correlational cross sectional design was used to study …

Dialect Contact: Lexical Availability As A Measure Of The Acquisition Of Characteristics From Another Dialect, Ross James Cairns

Theses and Dissertations

This study uses lexical availability as a way in which to measure the level of an individual's acquisition of the dialect of their spouse. Although lexical availability studies are in abundance, to the author's knowledge, this is one of the few, if not the only, type of study that uses lexical availability to measure dialect contact.

Lexical availability studies attempt to determine the most readily available lexical items in an individual's lexicon. This study implemented standard methodologies in order to determine whether dialect contact was more likely when specific topics were chosen. That is, if the topic in question was …

Using Declassified Satellite Imagery To Quantify Geomorphic Change: A New Approach And Application To Himalayan Glaciers, Joshua Michael Maurer

Theses and Dissertations

Himalayan glaciers are key components of earth's cryosphere, acting as hydrological reservoirs vital to many human and natural systems. Most Himalayan glaciers are shrinking in response to changing climate, which will potentially impact water resources, natural hazards, sea level rise, and many other aspects. However, there is much uncertainty regarding the state of these glaciers, as direct field data are difficult to obtain. Accordingly, long-timespan remote sensing techniques are needed to measure changing glaciers, which have memory and often respond to climate on decadal timescales. This study uses declassified historical imagery from the Hexagon spy satellite database to fulfill this …

A Simplified Performance-Based Procedure For The Prediction Of Lateral Spread Displacements, Levi Thomas Ekstrom

Theses and Dissertations

Characterization of the seismic hazard and ground-failure hazard of a site using traditional empirical lateral spread displacement models requires consideration of uncertainties in seismic loading, site conditions, and model prediction. Researchers have developed performance-based design methods to simultaneously account for these sources of uncertainty through the incorporation of a probabilistic analytical framework. While these methods can effectively handle the various sources of uncertainty associated with empirical lateral spread displacement prediction, they can be difficult for engineers to perform in a practical manner without the use of specialized numerical tools. To make the benefits of a performance-based approach accessible to a …

Service Dependency Analysis Via Tcp/Udp Port Tracing, John K. Clawson

Theses and Dissertations

Enterprise networks are traditionally mapped via layers two or three, providing a view of what devices are connected to different parts of the network infrastructure. A method was developed to map connections at layer four, providing a view of interconnected systems and services instead of network infrastructure. This data was graphed and displayed in a web application. The information proved beneficial in identifying connections between systems or imbalanced clusters when troubleshooting problems with enterprise applications.

Nonlocally Maximal Hyperbolic Sets For Flows, Taylor Michael Petty

Theses and Dissertations

In 2004, Fisher constructed a map on a 2-disc that admitted a hyperbolic set not contained in any locally maximal hyperbolic set. Furthermore, it was shown that this was an open property, and that it was embeddable into any smooth manifold of dimension greater than one. In the present work we show that analogous results hold for flows. Specifically, on any smooth manifold with dimension greater than or equal to three there exists an open set of flows such that each flow in the open set contains a hyperbolic set that is not contained in a locally maximal one.

Topics Pertaining To The Group Matrix: K-Characters And Random Walks, Randall Dean Reese

Theses and Dissertations

Linear characters of finite groups can be extended to take k operands. The basics of such a k-fold extension are detailed. We then examine a proposition by Johnson and Sehgal pertaining to these k-characters and disprove its converse. Probabilistic models can be applied to random walks on the Cayley groups of finite order. We examine random walks on dihedral groups which converge after a finite number of steps to the random walk induced by the uniform distribution. We present both sufficient and necessary conditions for such convergence and analyze aspects of algebraic geometry related to this subject.

Analysis Of Multiple Collision-Based Periodic Orbits In Dimension Higher Than One, Skyler C. Simmons

Theses and Dissertations

We exhibit multiple periodic, collision-based orbits of the Newtonian n-body problem. Many of these orbits feature regularizable collisions between the masses. We demonstrate existence of the periodic orbits after performing the appropriate regularization. Stability, including linear stability, for the orbits is then computed using a technique due to Roberts. We point out other interesting features of the orbits as appropriate. When applicable, the results are extended to a broader family of orbits with similar behavior.

Characterization Of Order-Disorder Phase Transition Temperature For Select Nanoparticles, Gregory J. Sutherland

Theses and Dissertations

A method was found for creating ordered nanoparticles whose size and theoretical order-disorder temperature are ideal for study in the TEM. Specifically FePt, NiPt, FeNiPt and AuCu nanoparticles were studied. We were able to show how a nanoparticle's size affects its order-disorder temperature (Tod). When the particles were around 6 nm in diameter there was a shift downward of the Tod of 10-15 percent compared to the bulk. While particles around 10 nm in diameter experienced a downward shift of 0-6 percent compared to the bulk. One can approximate that particles less than 10-15 nm in diameter would show significant …

Orchestrating Mathematical Discussions: A Novice Teacher's Implementation Of Five Practices To Develop Discourse Orchestration In A Sixth-Grade Classroom, Jeffrey Stephen Young

Theses and Dissertations

This action research study examined my attempts during a six-lesson unit of instruction to implement five practices developed by Stein, Engle, Smith, and Hughes (2008) to assist novice teachers in orchestrating meaningful mathematical discussions, a component of inquiry-based teaching and learning. These practices are anticipating student responses to a mathematical task, monitoring student responses while they engage with the task, planning which of those responses will be shared, planning the sequence of that sharing, and helping students make connections among student responses. Although my initial anticipations of student responses were broad and resulted in unclear expectations during lesson planning, I …