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Covalent Solutions To Biofilm Formation: Incorporation Of Antimicrobial Ceragenins Into Polymer-Brush Coatings, Jeffrey Clark, Dr. Paul Savage Aug 2013

Covalent Solutions To Biofilm Formation: Incorporation Of Antimicrobial Ceragenins Into Polymer-Brush Coatings, Jeffrey Clark, Dr. Paul Savage

Journal of Undergraduate Research

The accumulation of biofilm on urinary catheters and endotracheal tubes is one of the leading causes of hospital-acquired infection1. A variety of techniques have been developed to help mitigate this problem. One of these techniques is to coat devices with a biofilm-resistant polymer brush coating. Although these coatings may prevent adhesion by bacteria, they do not actively kill invading bacteria.

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A Speculative Approach To Parallelization In Particle Swarm Optimization, Matthew Gardner, Dr. Kevin Seppi Aug 2013

A Speculative Approach To Parallelization In Particle Swarm Optimization, Matthew Gardner, Dr. Kevin Seppi

Journal of Undergraduate Research

Optimization problems are ubiquitous in our modern world. Businesses such as Google need to decide where to place ads, scientists need to t models to data, and airlines need to schedule their flights. All of these problems are optimization problems, and optimization techniques can be used to find solutions. Particle swarm optimization (PSO) is a relatively new optimization technique that draws on ideas from the sociology of flocking birds. It was originally developed for use on a single machine, and attempts at modifying the algorithm to run in parallel are still quite preliminary. However, the problems people want to solve …

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The Efficacy Of Using Animal-Assisted Therapy To Decrease Maladaptive Behaviors In Children With Reactive Attachment Disorder, Trisha Markle, Dr. Gary Burlingame Aug 2013

The Efficacy Of Using Animal-Assisted Therapy To Decrease Maladaptive Behaviors In Children With Reactive Attachment Disorder, Trisha Markle, Dr. Gary Burlingame

Journal of Undergraduate Research

This study is currently still in progress. We are in the final stages of a pilot study that was supported by this ORCA grant. A new and funded version of the study will begin in January based upon the findings of the pilot. As noted in our IRB, our pilot study was conducted as a quality improvement project at Utah State hospital (USH).

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Effects Of Chronic Alcohol Intoxication On The Dopaminergic Reward Pathway, Brian Hoyt, Dr. Scott Steffensen Aug 2013

Effects Of Chronic Alcohol Intoxication On The Dopaminergic Reward Pathway, Brian Hoyt, Dr. Scott Steffensen

Journal of Undergraduate Research

My research project studied the effects of chronic alcohol intoxication on the brain’s pleasure center (the mesocorticolimbic system). I worked with JungJae Park (M.S. in neuroscience) and three other undergraduate students. Because rats dislike the taste of alcohol, we injected the alcohol directly into their abdominal cavity. This was done under isoflourane anesthesia to avoid any discomfort for the animals. We injected three experimental rats an intoxicating dose of alcohol twice daily for three weeks. Three other rats were used as control subjects (received saline injections twice daily).

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The Misapplication Of Dna Barcodes To Taxonomic Classification, Taylor Southwick, Dr. Keith Crandall Aug 2013

The Misapplication Of Dna Barcodes To Taxonomic Classification, Taylor Southwick, Dr. Keith Crandall

Journal of Undergraduate Research

The classification of organisms into different taxa is a central issue in biology. If similar organisms are grouped together, then comparative analyses can be used from the genome to the systems level to understand how they work, both biologically and behaviorally. There are two ways to perform this classification: morphologically and phylogenetically. Morphological demarcations are based on visual differences in anatomical structure and physiological function. Phylogenetic classification is based upon the evolutionary relationship among the individuals in the population quantified by the similarity or dissimilarity of their DNA strands.

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Quantification Of Kaposi’S Sarcoma Herpesvirus Gene Expression In Infected Humanized Mice, Mark Rowan, Dr. Bradford K. Berges Aug 2013

Quantification Of Kaposi’S Sarcoma Herpesvirus Gene Expression In Infected Humanized Mice, Mark Rowan, Dr. Bradford K. Berges

Journal of Undergraduate Research

Kaposi’s Sarcoma Herpesvirus (KSHV) is a prevalent disease around the world. Some Sub- Saharan African countries have infection levels as high as 40 percent. Usually the effects of this disease are not fatal unless the infected person has already been infected with HIV or has some other immunodeficiency. If both of these problems exist, deadly cancers can form within the infected person1. Studies have shown that people with HIV are 200,000 times more likely to have Kaposi’s sarcoma (a cancer caused by KSHV) than those not infected. Until now, no competent animal model existed to study KSHV pathogenesis.

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Does Selenium Alter The Expression Of The Large T Antigen In Tramp Mice?, Britlyn Orgill, Dr. Merrill Christensen Aug 2013

Does Selenium Alter The Expression Of The Large T Antigen In Tramp Mice?, Britlyn Orgill, Dr. Merrill Christensen

Journal of Undergraduate Research

Prostate cancer is the second most common cancer in American men. The American Cancer Society predicts that 217,730 cases of prostate cancer will be diagnosed and that 32,050 men will die from the disease in the year 2010 (1). Since prostate cancer has a long latency period, it is a prime candidate for dietary prevention. Isoflavones, natural compounds found in soy, and selenium, a trace element, have both been previously shown to have protective effects against prostate cancer. The lab of Dr. Merrill Christensen has been studying the effects of these compounds using the Transgenic Adenocarcinoma of the Mouse Prostate …

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The Role Of Rage In Inflammatory Lung Disease Induced By Diesel Particulate Matter, Karisa Wasley, Dr. Paul Reynolds Aug 2013

The Role Of Rage In Inflammatory Lung Disease Induced By Diesel Particulate Matter, Karisa Wasley, Dr. Paul Reynolds

Journal of Undergraduate Research

The causes of high morbidity and mortality associated with inflammatory respiratory diseases are not well understood. My research project helped to shed light on cellular signaling pathways associated with inflammatory disease, particularly those caused by or worsened by air pollutants. Asthmatics, in particular, have a difficult time dealing with common pollutants found in cities, including diesel particulate matter (PM). I focused specifically on the inflammation induced by air pollutants such as diesel PM and the activation of signaling pathways initiated by their binding with the receptors for advanced glycation end-products (RAGE). RAGE is involved developmentally in the lungs and specifically …

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Establishing The Spondyloepiphyseal Congenita Heterozygous Mouse As An Animal Model For Human Osteoarthritis, Michael Henderson, Dr. Robert Seegmiller Aug 2013

Establishing The Spondyloepiphyseal Congenita Heterozygous Mouse As An Animal Model For Human Osteoarthritis, Michael Henderson, Dr. Robert Seegmiller

Journal of Undergraduate Research

Osteoarthritis (OA) causes discomfort and immobility to millions of Americans every year. Due to the high demand for patient pain relief and improved mobility, scientists are seeking to understand the pathway of OA and develop drugs which would illuminate the onset of, and/or the progression of, OA.

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The Role Of Htra1, Ddr2, And Mmp-13 Proteins In The Mechanistic Pathway Leading To Osteoarthritis In Sedc Mice, David Holt, Robert Seegmiller Aug 2013

The Role Of Htra1, Ddr2, And Mmp-13 Proteins In The Mechanistic Pathway Leading To Osteoarthritis In Sedc Mice, David Holt, Robert Seegmiller

Journal of Undergraduate Research

In the present study, we report OA in a mouse model that, like the human families presented by Kannu et al., bears a heterozygous mutation in the Col2a1 gene but has a phenotypically normal skeleton.1 The mouse mutation was named sedc by Donahue et al. because when homozygous, it produces feature that resemble the most common clinical phenotypes of SED congenita in humans, including abnormal epiphyses, flattened vertebral bodies, and problems with the eyes and ears.2 The mutation consists of a single base pair substitution in exon 48 of the Col2a1 gene, which changes an arginine to a cysteine in …

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A Multiplex Real-Time Pcr Assay For Rapid Detection And Differentiation Of Burkholderia Mallei, B. Pseudomallei, And B. Thailandensis, Chinn-Woan Shih, Richard Robison Aug 2013

A Multiplex Real-Time Pcr Assay For Rapid Detection And Differentiation Of Burkholderia Mallei, B. Pseudomallei, And B. Thailandensis, Chinn-Woan Shih, Richard Robison

Journal of Undergraduate Research

As stated in the proposal, my focus has been with three bacterial species of Burkholderia: mallei, pseudomallei, and thailandensis. Burkholderia mallei is the causative agent of glanders, an abscess-forming infection that is predominantly found in the equine population and is capable of being transmitted to humans from infected animals. There is documentation that B. mallei was used as a biowarfare agent in World War I (Gee et al., 2003).

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Genetic Investigation Of The Pathology Of Ustilago Bullata, Erin Ladle, Dr. Jeff Maughan Aug 2013

Genetic Investigation Of The Pathology Of Ustilago Bullata, Erin Ladle, Dr. Jeff Maughan

Journal of Undergraduate Research

Bromus tectorum L., commonly known as cheatgrass, is an invasive annual grass species that dominates millions of hectares of land in the Great Basin area, in the western United States.1 The widespread invasion of cheatgrass has increased fire incidence in some areas of the Great Basin from every 30-100 years to every 5 years. Moreover, once cheatgrass becomes the dominant vegetative species, it monopolizes resources, significantly contributing to the endangerment of many native plant species.

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Selenium’S Effect On Insulin Resistance, Scott Brunson, Chad Hancock Aug 2013

Selenium’S Effect On Insulin Resistance, Scott Brunson, Chad Hancock

Journal of Undergraduate Research

Due to dramatic increases in type II diabetes, studies on insulin resistance are especially applicable to this current health issue. Previous epidemiological studies examining selenium’s effect on prostate cancer observed a possible correlation between increased risk for type II diabetes mellitus and increased selenium levels in humans (Lippman, S.M.2009). However, in other studies contradictory results have been recorded. Due to these inconsistencies we are investigating the effects of selenium on insulin resistance. If increased dietary selenium causes insulin resistance, we will examine the mechanism by which this occurs.

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Promoting Healthy Home Environments For Asthma Risk Reduction In Utah County, Utah, Cecilia Fernandez, Dr. Gene Cole Aug 2013

Promoting Healthy Home Environments For Asthma Risk Reduction In Utah County, Utah, Cecilia Fernandez, Dr. Gene Cole

Journal of Undergraduate Research

To conduct an initial needs assessment relative to the promotion of healthy home environments and asthma risk reduction, with a focus on multi-family dwellings and ethnic minority populations (primarily Hispanic).

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Development Of A Sense And Avoid System For Small Unmanned Aircraft Systems, Robert Andrew Klaus Aug 2013

Development Of A Sense And Avoid System For Small Unmanned Aircraft Systems, Robert Andrew Klaus

Theses and Dissertations

Unmanned aircraft systems (UAS) represent the future of modern aviation. Over the past 10 years their use abroad by the military has become commonplace for surveillance and combat. Unfortunately, their use at home has been far more restrictive. Due to safety and regulatory concerns, UAS are prohibited from flying in the National Airspace System without special authorization from the FAA. One main reason for this is the lack of an on-board pilot to "see and avoid" other air traffic and thereby maintain the safety of the skies. Development of a comparable capability, known as "Sense and Avoid" (SAA), has therefore …

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Natural History Museums Of Early Utah Settlement, Leslie Evens Jul 2013

Natural History Museums Of Early Utah Settlement, Leslie Evens

Library Research Grants

No abstract provided.

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Popup Height And The Dynamics Of Rising Buoyant Spheres, Randy H. Munns Jul 2013

Popup Height And The Dynamics Of Rising Buoyant Spheres, Randy H. Munns

Theses and Dissertations

In this paper the popup height of rising buoyant spheres is studied over a range of distinct release depths along with the accompanying velocities and accelerations near the free surface. In the past, regimes of motion due to vortex induced vibrations have been classified based on trajectories below the free surface. This study focuses on the popup height, velocity and acceleration at free surface exit, and vortex shedding in order to further define regimes of motion experienced by a rising buoyant sphere. Varying the release depth below the free surface reveals varying exit angles, velocities, accelerations, and popup heights at …

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Improvements In Diffusion Weighted Imaging Through A Composite Body And Insert Gradient Coil System, Peter Austin Jepsen Jul 2013

Improvements In Diffusion Weighted Imaging Through A Composite Body And Insert Gradient Coil System, Peter Austin Jepsen

Theses and Dissertations

Diffusion Magnetic Resonance Imaging (DMRI) is a class of Magnetic Resonance Imaging (MRI) techniques with broad medical applications ranging from characterization of tumors and brain damage to potential prediction of stroke. Gradient coil and signal-to- noise ratio (SNR) constraints limit spatial resolution, accuracy, and scan time in DMRI. Achieving high b-values (measures of a scan's sensitivity to diffusion) often require scans with long diffusion gradient pulses, leading to significant magnetic resonance (MR) signal decay before the signal can be sampled. This signal loss reduces the accuracy of diffusion parameter estimation. The ability to sample the MR signal sooner while maintaining …

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European Emerging Adults In The Context Of Free Time And Leisure, Eric K. Layland Jul 2013

European Emerging Adults In The Context Of Free Time And Leisure, Eric K. Layland

Theses and Dissertations

Research on emerging adulthood has increased over the past decade, including further investigation of the five features of emerging adulthood: (a) exploring identity, (b) instability, (c) focus on self, (d) feeling in-between, and (e) possibilities (Arnett, 2004). Despite an increased focus on this age period (i.e., 18 -- 29 year olds), research has not addressed the context of free time and leisure. Trends among European emerging adults include increased delay of marriage, decreased childbirth, and general postponement of adult markers. Both the high cultural valuation of leisure and the apparent change in patterns of external markers (i.e., sustained low fertility …

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A Theory Of Text As Action:Why Delivery Through Publication Improves Student Writers And Their Writing, Lisa Kae Thomas Jul 2013

A Theory Of Text As Action:Why Delivery Through Publication Improves Student Writers And Their Writing, Lisa Kae Thomas

Theses and Dissertations

Students in required writing courses often fail to see the purpose of their writing and invest themselves in their writing. Many composition pedagogues have noticed that one solution to this problem is to help students publish their writing, and have reported the positive outcomes of their publication-focused courses. However, this practice has not been grounded in theory. My project connects the practice of publishing student writing to theory. I draw on Kenneth Burke's and other's ideas of text as action and show how the ancient cannon of delivery is a necessary means of experiencing and understanding text as action with …

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Memory As Ecology In The Poetry Of Tomas Tranströmer, Richelle Jolene Wilson Jul 2013

Memory As Ecology In The Poetry Of Tomas Tranströmer, Richelle Jolene Wilson

Theses and Dissertations

The purpose of this study is to explore how memory functions ecologically in the poetry of Tomas Tranströmer. The term ecology is useful because of its connotative associations with the natural world as well as its broader definition of being a network of relationships as they function within and relate to their environment. Throughout his oeuvre, Tranströmer positions memory as being an external presence with which he interacts primarily because he honors it as a living being and he feels a poetic responsibility to it. As such, he grapples with the challenges of representation, particularly the limitations of language. Ultimately, …

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The Effectiveness Of Systematic And Engaging Early Literacy (Seel) Intervention On Word Reading In Kindergarten Students Receiving Tier 3 Services, Christina Haley Cole Jul 2013

The Effectiveness Of Systematic And Engaging Early Literacy (Seel) Intervention On Word Reading In Kindergarten Students Receiving Tier 3 Services, Christina Haley Cole

Theses and Dissertations

This study evaluated the effectiveness of the Systematic and Engaging Early Literacy (SEEL) intervention method to improve consonant-vowel-consonant (CVC) reading in four students receiving Tier 3 services. The SEEL intervention method was also combined with the use of digital books on an iPad to investigate the effects of using technology in reading intervention sessions. Previous research indicates effectiveness for the foundational principles of SEEL, which include instruction in engaging, meaningful contexts that provide frequent and intense opportunities to practice. This research involved 4 kindergarten students who qualified for Tier 3 services based on their performance on an index of difficulty …

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Social Networks Of Children With Language Impairment, Serena Marita Louisa Mickelson Jul 2013

Social Networks Of Children With Language Impairment, Serena Marita Louisa Mickelson

Theses and Dissertations

Children with language impairment (LI) often exhibit social difficulties along with language issues that can affect their friendships with peers. This study sought to identify the self-reported social networks of children with LI and compare them to the self-reported social networks of children with typical language development. Sixteen children with LI (9 girls and 7 boys) between the ages of 5-11 years, and sixteen children with typical language development matched for age and gender were studied. Children were asked to name interactants in four social circles (Blackstone & Hunt Berg, 2003): family, friends, acquaintances, and paid interactants. A parent also …

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Plasma Lactate Accumulation During Running With Body Weight Unloading By Lbpp, Nicole Nevitt Rasmussen Jul 2013

Plasma Lactate Accumulation During Running With Body Weight Unloading By Lbpp, Nicole Nevitt Rasmussen

Theses and Dissertations

At any given running speed, weight support with a lower body positive pressure (LBPP) device (i.e. Alter-G treadmill) reduces V̇O2. However, it is unknown how application of LBPP during running impacts lactate metabolism, specifically lactate threshold. Purpose: To determine if body weight unloading with the Alter-G treadmill alters lactate threshold. Methods. Maximal aerobic capacity (V̇O2max) and lactate threshold (LT) was determined in 8 male subjects on an Alter-G treadmill at 100% and 80% body weight loading at 0% grade in a randomized crossover design. V̇O2max tests started at 7 mile h-1 and increase speed by 1 mile h-1 every 2 …

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The Rise Of Humor: Hollywood Increases Adult Centered Humor In Animated Children's Films, Chelsie Lynn Akers Jul 2013

The Rise Of Humor: Hollywood Increases Adult Centered Humor In Animated Children's Films, Chelsie Lynn Akers

Theses and Dissertations

Children's animated films have held a lasting influence on their audiences since the rise of their popularity in the 1980s. As adults co-view such films with their children Hollywood has had to rewrite the formula for a successful animated children's film. This thesis argues that a main factor in audience expansion is adult humor. The results show that children's animated films from 2002-2013 are riddled with many instances of adult humor while earlier films from 1982-1993 use adult humor sparingly. It is clear that over the years the number of adult humor occurrences has consistently increased. Furthermore, this research shows …

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The Physical Theatre Of War: Language, Memory, And Gender In Black Watch And War Horse, Andrea M. Gunoe Jul 2013

The Physical Theatre Of War: Language, Memory, And Gender In Black Watch And War Horse, Andrea M. Gunoe

Theses and Dissertations

The public's perception of war is influenced by every media story they see, every account they read, and every story they hear. News telecasts and newspapers tend to lean towards a focus of the grand narratives of war such as political involvement and overarching strategy. Media such as books and film can tell a more personal narrative of the events of war and attempt to display how war "really is" through the use of written and visual language that focuses more on how things happened as opposed to simply what happened. Theatre provides a unique perspective on war as the …

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Bibliotherapy And Bullying: Teaching Young Childrento Utilize Peer Group Power To Combat Bullying, Rebecca Lyn Spencer Jul 2013

Bibliotherapy And Bullying: Teaching Young Childrento Utilize Peer Group Power To Combat Bullying, Rebecca Lyn Spencer

Theses and Dissertations

Bullying is a major concern for school-age children. This study compares the use of bibliotherapy and didactic instruction techniques for teaching anti-bullying strategies to young children. The study explores 36 first graders' perceptions of bullying and their perceptions of their roles and responsibilities in bullying situations. In comparison to the control group, students who were taught specific bully intervention skills, both through didactic instruction and bibliotherapy, reflected an increased understanding of bullying, used a larger bully vocabulary, and demonstrated more specific and varied actions in response to bullying from pre-test to post-test conditions. Participants in the group who received didactic …

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Nuclear Bmp2 And The Immune Response, Daniel S. Olsen Jul 2013

Nuclear Bmp2 And The Immune Response, Daniel S. Olsen

Theses and Dissertations

Nuclear bone morphogenetic protein 2 (nBMP2) is a nuclear variant of the secreted growth factor BMP2. Experiments in nBmp2NLStm mutant mice, which lack nBMP2 in the nucleus, have shown that nBMP2 affects intracellular calcium transport in skeletal muscle and hippocampal neurons. The objective of this study was to determine whether nBMP2 affects the immune system, since activation of lymphocytes and other immune cells depends on intracellular calcium transport. We found that spleens in nBmp2NLStm mutant mice were 24% smaller than in wild type mice. The white pulp of the spleen contains many immune cells, particularly B and T lymphocytes and …

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Factors Underlying Invasive Grass Fire Regimes In The Mojave Desert And Its Consequences On Plant And Animal Communities, Kevin J. Horn Jul 2013

Factors Underlying Invasive Grass Fire Regimes In The Mojave Desert And Its Consequences On Plant And Animal Communities, Kevin J. Horn

Theses and Dissertations

Climate change and exotic plant invasions are significant anthropogenic threats to desert community structure and resilience . In the Mojave Desert, the invasive grass red brome (Bromusrubens L) is increasing fire frequency and extent in response to climatic factors. The resilience of this ecosystem will be affected by how plant and animal communities respond to fire. To better understand these dynamics, we studied the environmental factors underlying changes in invasive grass fire regimes in the Mojave Desert and its structural and functional effects on plant and animal communities. Following fire, reestablishment of native vegetation can be preempted by repeated burning …

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Zofia Stryjeńska: Women In The Warsaw Town Square. Our Lady, Peasant Mother, Pagan Goddess, Katelyn Mckenzie Sheffield Jul 2013

Zofia Stryjeńska: Women In The Warsaw Town Square. Our Lady, Peasant Mother, Pagan Goddess, Katelyn Mckenzie Sheffield

Theses and Dissertations

In this thesis I consider the unique position that Polish artist Zofia Stryjeńska (1891-1974) occupied during the interwar period. Lauded during her time as the most popular artist in Poland, the acceptance of Stryjeńska's female voice in representing a national vocabulary was unprecedented and deserves closer examination. I assert that Poland's history of oppression created a unique environment where women as archetypal figures often took on masculine roles. These 'transgressive types' were visible in the literature and art of the 19th and 20th centuries. Stryjeńska's art, as well as her behavior, capitalized on these transgressive traditions. Women played an important …

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