Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Social and Behavioral Sciences (654447)
- Arts and Humanities (572276)
- Law (543779)
- Education (380166)
- Medicine and Health Sciences (322011)
-
- Physical Sciences and Mathematics (289994)
- Life Sciences (253393)
- Engineering (193512)
- History (181316)
- Business (148810)
- Higher Education (142501)
- Anthropology (115519)
- Religion (109810)
- Archaeological Anthropology (96396)
- Communication (88957)
- Sociology (86656)
- Library and Information Science (77957)
- United States History (77658)
- Medical Specialties (76908)
- Psychology (73192)
- Public Affairs, Public Policy and Public Administration (62633)
- Computer Sciences (62601)
- Earth Sciences (58971)
- Creative Writing (57857)
- Public Health (53616)
- Environmental Sciences (51556)
- English Language and Literature (47289)
- Economics (47100)
- Educational Administration and Supervision (46455)
- Music (45923)
- Institution
-
- University of South Florida (162226)
- University of New Mexico (137236)
- University of Nebraska - Lincoln (113938)
- Kenyon College (112828)
- University of Montana (97734)
-
- University of Mississippi (94004)
- University of New Hampshire (79563)
- Brigham Young University (71994)
- Georgia Southern University (60720)
- Eastern Illinois University (57751)
- Utah State University (56347)
- Mississippi State University (54324)
- Western Michigan University (51931)
- University of Kentucky (51838)
- Murray State University (50370)
- Purdue University (49579)
- University of Colorado Law School (47480)
- Louisiana State University (44983)
- Brigham Young University Law School (43856)
- University of Dayton (43083)
- Western Kentucky University (42860)
- Villanova University Charles Widger School of Law (42797)
- California Polytechnic State University, San Luis Obispo (42384)
- University of Central Florida (41293)
- Chulalongkorn University (37685)
- San Jose State University (37022)
- University of Alabama at Birmingham (36075)
- University of Northern Iowa (35970)
- Yale University (33672)
- Missouri University of Science and Technology (33235)
- Keyword
-
- Newspaper (47930)
- Latin America (31529)
- Press release; media release; press statement; news media information (30839)
- Spanish (30821)
- History (29927)
-
- University of New Mexico (29734)
- Humans (29641)
- UNM (29638)
- LADB (29608)
- LAII (29608)
- Latin American and Iberian Institute (29608)
- Education (28843)
- United States (21324)
- Student newspaper (20016)
- Newsletter (19708)
- EIU (19630)
- Georgia Southern University (18957)
- Newspapers (18229)
- Deaf culture (17101)
- Hearing impaired (17090)
- Pastoral care of people with disabilities (17060)
- Church work with the deaf -- Catholic Church (17052)
- Deaf -- Periodicals (17043)
- Athletics (16848)
- Marriage (16180)
- Poetry (15501)
- Students (15088)
- Higher education (14521)
- Female (14352)
- English (13907)
- Publication Year
-
- 2026 (107877)
- 2025 (155131)
- 2024 (191347)
- 2023 (161085)
- 2022 (165696)
-
- 2021 (192977)
- 2020 (165923)
- 2019 (163183)
- 2018 (168023)
- 2017 (158804)
- 2016 (157778)
- 2015 (144892)
- 2014 (134324)
- 2013 (128840)
- 2012 (123501)
- 2011 (106326)
- 2010 (102720)
- 2009 (95038)
- 2008 (90802)
- 2007 (78603)
- 2006 (74068)
- 2005 (69767)
- 2004 (70996)
- 2003 (58461)
- 2002 (64399)
- 2001 (54970)
- 2000 (58399)
- 1996 (62248)
- 1992 (52967)
- 1990 (53658)
- Publication
-
- Four Valleys Archive (90456)
- Theses and Dissertations (74032)
- Faculty Publications (45588)
- Electronic Theses and Dissertations (35647)
- University of Montana News Releases, 1928, 1956-present (30911)
-
- Faculty Scholarship (25396)
- Dissertations (23769)
- The Auk (22791)
- Theses (21718)
- Documents (21654)
- Articles (20087)
- Walden Dissertations and Doctoral Studies (19630)
- Browse All News (19555)
- Masters Theses (18652)
- Master's Theses (18436)
- Chulalongkorn University Theses and Dissertations (Chula ETD) (15281)
- Session Laws 1951-2000 (15051)
- NotiSur (13785)
- Faculty, Staff and Student Publications (13699)
- Hillsborough County Marriage Records (13681)
- University of Mississippi News (13497)
- Obituaries (13320)
- The Murray Ledger & Times (13003)
- Sheet Music Collection (12976)
- Michigan Law Review (12791)
- University of Montana Course Syllabi (12469)
- Honors Theses (12182)
- Defensive Publications Series (12006)
- Graduate Theses, Dissertations, and Problem Reports (ETD) (11889)
- Condor (11821)
Articles 5281 - 5310 of 5126969
Full-Text Articles in Entire DC Network
Teaching Communication And Teamwork Under Pressure: An Experiential Activity Using Keep Talking And Nobody Explodes, Bryan L. Rogers, Cody Logan Chullen, Brian Waterwall
Teaching Communication And Teamwork Under Pressure: An Experiential Activity Using Keep Talking And Nobody Explodes, Bryan L. Rogers, Cody Logan Chullen, Brian Waterwall
International Journal for Business Education
Background/Introduction/Purpose: The purpose of this paper is to present an experiential classroom activity designed to help students develop communication and teamwork skills under conditions of time pressure and information asymmetry.
Methods/Design: This paper presents a teaching activity rather than an empirical study; no research design, sample, instruments, or analytic procedures are reported. The paper describes and contextualizes an experiential learning activity using the cooperative video game Keep Talking and Nobody Explodes. Drawing on research in experiential learning, cooperative learning, and simulation-based instruction, the paper outlines learning objectives, materials, implementation procedures, observer roles, and structured debriefing strategies suitable for undergraduate and …
Hospitality And Tourism Students’ Perceptions Of Well-Being, Belonging, And Engagement In Their Academic Endeavors And Extracurricular Activities, Cynthia S. Deale, Seung Hyun Lee
Hospitality And Tourism Students’ Perceptions Of Well-Being, Belonging, And Engagement In Their Academic Endeavors And Extracurricular Activities, Cynthia S. Deale, Seung Hyun Lee
International Journal for Business Education
Background/Introduction/Purpose: This study examined hospitality and tourism college/university students’ views of their engagement, well-being, and sense of belonging in academic and extracurricular activities, based on 130 responses from students in the United States.
Methods: Descriptive analysis, analysis of variance, confirmatory factor analysis, and structural equation modeling were used to analyze the responses. Qualitative comments were also obtained.
Results: Respondents felt positive overall about their engagement, and many participated in extracurricular activities. The relationships between class engagement and sense of belonging, and between campus engagement and sense of belonging were significant, and the sense of belonging significantly influenced student subjective …
Montana Kaimin, September 10, 2026, Students Of The University Of Montana, Missoula
Montana Kaimin, September 10, 2026, Students Of The University Of Montana, Missoula
Montana Kaimin, 1898-present
Student newspaper of the University of Montana, Missoula.
Preclinical Efficacy Of A Gene Therapy For Chkb-Mediated Muscular Dystrophy, Mahtab Tavasoli, Mariam Alkandari, Gabriel Dorighello, Jennifer Devitt, Laura Hagerty, Jesse Damsker, Eric P. Hoffman, Christopher R. Mcmaster
Preclinical Efficacy Of A Gene Therapy For Chkb-Mediated Muscular Dystrophy, Mahtab Tavasoli, Mariam Alkandari, Gabriel Dorighello, Jennifer Devitt, Laura Hagerty, Jesse Damsker, Eric P. Hoffman, Christopher R. Mcmaster
Pharmacy Faculty Scholarship
Loss-of-function variants of the CHKB gene cause an autosomal recessive disease described as an early onset congenital megaconial (large peripheral mitochondria) muscular dystrophy. CHKB encodes choline kinase β, the first enzyme in the biochemical pathway for synthesis of the major membrane phospholipid phosphatidylcholine. Chkb-/- mice recapitulate the human disease with affected skeletal muscle displaying a decrease in strength, myofiber atrophy, megaconial mitochondria, fat accumulation within muscle cells, and an increase in muscle injury. Here, we assessed the therapeutic potential of an AAV therapy for the treatment of CHKB-mediated muscular dystrophy. Chkb-/- mice were injected once suborbitally with three different doses …
Taut And Dupin Submanifolds (Updated Version), Thomas E. Cecil
Taut And Dupin Submanifolds (Updated Version), Thomas E. Cecil
Mathematics and Computer Science Department Faculty Scholarship
This is an updated version of the paper [29] by the author which originally appeared in 1997. The original paper was a survey of the closely related fields of taut and Dupin submanifolds of Euclidean space, and this updated version includes many results in the field that have appeared since the publication of the original version. The emphasis is on stating results in their proper context and noting areas for future research, and relatively few proofs are given. The important class of isoparametric hypersurfaces is surveyed in detail, as is the relationship between the two concepts of taut and Dupin. …
Wmu Board Of Trustee Board Meeting, Thursday, September 10, 2026, Wmu Board Of Trustees
Wmu Board Of Trustee Board Meeting, Thursday, September 10, 2026, Wmu Board Of Trustees
WMU Board of Trustees Meetings
Acceptance of the Agenda
Approval of the Minutes (June 25, 2026)
Remarks by the Chair of the Board
Remarks by the President
Updates by the Faculty Senate President
Updates by the Western Student Association President
Updates by the Graduate Student Association President
AFSCME Adopt-A-Highway Project and Food Drive
WMU Particle Accelerator Lab, Physics Department
Western Michigan University Employee Graduates
Public Comments Regarding Action Items
Action Items
American Association of University Professors (AAUP) Labor Agreement
Honorary Degree Recommendation for David Dombrowski
Consent Items
- Donation of Real Estate to the City of Kalamazoo
- Personnel Report
- Curriculum Proposals
- Annuity and Life Income Funds …
Incremental Prognostic Value Of The Triglyceride–Glucose Index Beyond The Grace Score For Predicting 30-Day Major Adverse Cardiovascular Events In Non St-Elevation Myocardial Infarction Patients Undergoing Percutaneous Coronary Intervention, Fathi Zahra, Cut A. Andra, Abdul H. Raynaldo, Andika Sitepu, Hilfan A. P. Lubis, Kamal K. Ilyas
Incremental Prognostic Value Of The Triglyceride–Glucose Index Beyond The Grace Score For Predicting 30-Day Major Adverse Cardiovascular Events In Non St-Elevation Myocardial Infarction Patients Undergoing Percutaneous Coronary Intervention, Fathi Zahra, Cut A. Andra, Abdul H. Raynaldo, Andika Sitepu, Hilfan A. P. Lubis, Kamal K. Ilyas
Journal of the Hong Kong College of Cardiology
Background: The Global Registry of Acute Coronary Events (GRACE) score is widely used for risk stratification in patients with non–ST-elevation myocardial infarction (NSTEMI). However, it does not account for metabolic factors such as insulin resistance, which may contribute to residual cardiovascular risk. The triglyceride–glucose (TyG) index has emerged as a simple surrogate marker of insulin resistance with potential prognostic value. This study aimed to evaluate the incremental value of the TyG index beyond the GRACE score for predicting short-term outcomes.
Methods: In this retrospective observational design study, 110 patients with NSTEMI undergoing percutaneous coronary intervention (PCI) at Adam Malik Hospital, …
The Parthenon, September 10, 2026, Trista Honaker, Davina Snyder, Soleil Woolard, Alana Romero Lozano, Claire Johnson, Hannah Anderson, Tally Mamula
The Parthenon, September 10, 2026, Trista Honaker, Davina Snyder, Soleil Woolard, Alana Romero Lozano, Claire Johnson, Hannah Anderson, Tally Mamula
The Parthenon
No abstract provided.
Enhancing Hiv Knowledge And Resource Awareness Among Chief Nursing Officers, Susan Louise Cooper Bailey
Enhancing Hiv Knowledge And Resource Awareness Among Chief Nursing Officers, Susan Louise Cooper Bailey
Walden Dissertations and Doctoral Studies
Human immunodeficiency virus (HIV) remains a significant public health concern in rural communities, where limited specialty care, geographic isolation, transportation barriers, and stigma may delay testing and entry into care. The Texas Panhandle is a geographically expansive rural region served by rural hospitals with limited resources. Although area HIV services are available, they are inconsistently utilized. Although chief nursing officers (CNOs) influence practice and care coordination, knowledge gaps regarding HIV guidelines, prevention strategies, and regional resources may limit identification, referral, and continuity of care. The purpose of this doctor of nursing practice (DNP) project was to determine whether a targeted …
Drug Court Graduation Rates Of African American Males Attending Habilitation Empowerment Accountability Therapy, Tierney President
Drug Court Graduation Rates Of African American Males Attending Habilitation Empowerment Accountability Therapy, Tierney President
Walden Dissertations and Doctoral Studies
African American males between the ages of 18 and 29 have lower rates of successful completion in drug court programs compared to other populations, increasing their risk of incarceration and recidivism. This study examined whether participation in the Habilitation Empowerment Accountability Therapy (HEAT) program, a culturally responsive intervention, was associated with improved drug court graduation outcomes among African American male participants. Guided by cognitive behavioral theory, a quantitative retrospective causal-comparative design was used to analyze archival data from 96 African American male participants enrolled in a drug treatment court program in Columbia, Missouri. A chi-square test of independence was conducted …
The Impact Of Leadership Styles From Traditional Policing To Community Policing, Ryan Gates
The Impact Of Leadership Styles From Traditional Policing To Community Policing, Ryan Gates
Walden Dissertations and Doctoral Studies
This study examines leadership in a community policing context. It addresses a long-standing problem: injustice, inequality, and unfair treatment. Specifically, it examines community policing and the impact of law enforcement leadership, particularly servant leadership, on policing outcomes. Greenleaf’s Theory of Servant Leadership guided this study. Participants included mid- to senior-level law enforcement officers with community policing experience, at least three years of leadership experience, and at least 18 years of age. Recruitment occurred through social media outlets such as Facebook and Instagram. Data were collected through semi-structured interviews with 19 participants. Thematic analysis produced six themes: community engagement and partnerships; …
Fractured Identities: Military–Civilian Dissonance And The Well-Being Of Women Veterans, Melissa D. Smith
Fractured Identities: Military–Civilian Dissonance And The Well-Being Of Women Veterans, Melissa D. Smith
Walden Dissertations and Doctoral Studies
For many women leaving military service, the path to civilian life involves a fundamental renegotiation of identity. Gender-specific pressures, institutional norms, and fractured belonging compound reintegration, yet the lived experiences of women veterans navigating competing identities remain underexplored. The purpose of this phenomenological study was to understand the lived experiences of women veterans at least 5 years postdischarge who struggled with identity dissonance between their military and civilian identities. The study was informed by reculturation theory. Seven women veterans participated in semistructured interviews, and data were analyzed using Braun and Clarke’s thematic analysis, revealing five themes: institutions, culture, and unequal …
Draft Final 2023 Unreclaimed Sites Sampling: Ur-43 Site Evaluation Summary Report, Pioneer Technical Services, Inc.
Draft Final 2023 Unreclaimed Sites Sampling: Ur-43 Site Evaluation Summary Report, Pioneer Technical Services, Inc.
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
The Effectiveness Of A Prenatal Educational Programme On Fear Of Childbirth Among Primigravida Women: A Quasi-Experimental Pretest–Post-Test Study, Mozah Al Mamari, Amal Al Hadi, Fahima Al Harthy, Shamsa Al Ghusaini, Kadhiya Al Riyami
The Effectiveness Of A Prenatal Educational Programme On Fear Of Childbirth Among Primigravida Women: A Quasi-Experimental Pretest–Post-Test Study, Mozah Al Mamari, Amal Al Hadi, Fahima Al Harthy, Shamsa Al Ghusaini, Kadhiya Al Riyami
Sultan Qaboos University Medical Journal
Objectives: Fear of childbirth is commonly reported among primigravida women and may negatively influence labour and birth outcomes. This study aimed to evaluate the effectiveness of a structured prenatal educational programme in reducing fear of childbirth among primigravida women. Methods: A quasi-experimental single-group pretest-post-test design was conducted from January to June 2025. The study included primigravida women attending antenatal clinics in selected health centres in Muscat Governorate, Oman. No control group was included. Participants completed the baseline assessment during the third trimester (28–40 weeks of gestation) prior to the intervention. Post-intervention assessment was conducted at two weeks postpartum using the …
2026-09-10 Message From The President, Morehead State University. Office Of The President.
2026-09-10 Message From The President, Morehead State University. Office Of The President.
Staff Congress Records
Message sent on September 10, 2026 by the President to the campus community regarding upcoming dates and events for the Fall Semester, personeele and academic, construction news, campus personnel recognitions and other updates, summary of the Board of Regents meeting, and honoring University Legacies.
Thomas Gage V. Borough Of Hopatcong
Thomas Gage V. Borough Of Hopatcong
2026 Decisions
USDC for the District of New Jersey
September 2026 Graduate Council Minutes, University Of Nebraska At Kearney Graduate Council
September 2026 Graduate Council Minutes, University Of Nebraska At Kearney Graduate Council
Graduate Council Minutes
No abstract provided.
On-Shell Compression And Reconstruction (Oscar) Of Monochromatic Wave Fields In Weakly Scattering Media, Pablo Jara, Alexey Yamilov
On-Shell Compression And Reconstruction (Oscar) Of Monochromatic Wave Fields In Weakly Scattering Media, Pablo Jara, Alexey Yamilov
Research Data
Overview
This deposit contains one realization of each of the two simulation platforms of Ref. [1], a two-dimensional (2D) scalar field and a three-dimensional (3D) vector-field component, together with two self-contained Python scripts that perform On-Shell Compression and Reconstruction (OSCAR) on them. Each script Fourier-transforms the stored field, measures the shell radius from the spectrum, retains only the Fourier components inside the shell of full width α/ℓs around it for α = 1, 3, 5, 8, 12, reconstructs the field by the inverse transform, and plots the reconstructed intensities, panels (a)–(e), next to the original field, panel (f), on a …
The Role Of Generative Ai In Secondary School Business Education: Insights From Teachers’ Perceptions, Leonard Busuttil, Emanuel Mizzi
The Role Of Generative Ai In Secondary School Business Education: Insights From Teachers’ Perceptions, Leonard Busuttil, Emanuel Mizzi
International Journal for Business Education
Background/Introduction/Purpose: Generative artificial intelligence (GenAI) has entered classrooms more quickly than the evidence base needed to guide its use, and that evidence base remains concentrated in higher education. Comparatively little is known about secondary school business education, a curricular area that brings together accounting, business studies, economics, financial literacy, marketing, and retail, and in which teachers move between subjects whose epistemological and procedural demands differ considerably. Existing studies also tend to treat business education as a single homogeneous domain, or to examine one of its subjects in isolation. This study addresses that gap by examining how secondary school business education …
September 10, 2026, The Daily Mississippian
September 10, 2026, The Daily Mississippian
Daily Mississippian (all digitized issues)
No abstract provided.
'Not Done Yet', September 10, 2026, Tisa Mason Ed.D.
'Not Done Yet', September 10, 2026, Tisa Mason Ed.D.
Heart of a Tiger Columns
No abstract provided.
Efficacy Of Statins In Preventing Microvascular Complications In Type 2 Diabetes- A Systematic Review And Meta-Analysis, Hare Krishna, Prithpal Singh Matreja, Shehzeen Afaq, Vk Singh, Ajay Kumar
Efficacy Of Statins In Preventing Microvascular Complications In Type 2 Diabetes- A Systematic Review And Meta-Analysis, Hare Krishna, Prithpal Singh Matreja, Shehzeen Afaq, Vk Singh, Ajay Kumar
Journal of the Hong Kong College of Cardiology
Background: Microvascular complications—diabetic retinopathy, nephropathy, and neuropathy—remain major contributors to morbidity in type 2 diabetes mellitus. Statins, widely used for cardiovascular risk reduction, have been proposed to exert additional microvascular protective effects via pleiotropic mechanisms, though evidence remains inconsistent.
Methods: A systematic review and meta-analysis were conducted in accordance with PRISMA guidelines, including randomized controlled trials and observational studies evaluating statin efficacy in preventing microvascular complications. Data on demographics, biochemical parameters, and clinical outcomes were extracted. A random-effects model (RevMan 5.4.1) was used, with outcomes reported as odds ratios (OR) and mean differences (MD) with 95% confidence intervals (CI).
Results: …
Kenyon Collegian - September 10, 2026
Doing Less With More: A First-Principles Exploration Of The Suitability Of Agentic Computing Over Alternative Architectural Choices, Ritvik Garimella, Biplav Srivastava, Amit Sheth
Doing Less With More: A First-Principles Exploration Of The Suitability Of Agentic Computing Over Alternative Architectural Choices, Ritvik Garimella, Biplav Srivastava, Amit Sheth
Publications
There is growing interest in automating business activities with Agentic Artificial Intelligence (AI) due to latter's seeming ease of use. Never has it been easier, or costlier, to do less with more. However, little is known about when agents are preferable to established alternatives such as local computation, Representational State Transfer (REST), the Simple Object Access Protocol (SOAP), and the Model Context Protocol (MCP), particularly when development speed, performance, and operational cost are considered. We investigate this question using a controlled mathematical task that compares seven methods on a benchmark of 1,000 arithmetic expressions where semantics of operator precedence has …
The George-Anne Daily, Georgia Southern University
The George-Anne Daily, Georgia Southern University
George-Anne Media Group: Newsletters & Magazines
No abstract provided.
Beyond Cusp Count: Bicuspid Function In A Quadricuspid Aortic Valve, Aneeq Ahmed, Suhail Khan, Luigia D'Errico
Beyond Cusp Count: Bicuspid Function In A Quadricuspid Aortic Valve, Aneeq Ahmed, Suhail Khan, Luigia D'Errico
Journal of the Hong Kong College of Cardiology
Quadricuspid aortic valve is a rare congenital anomaly usually associated with regurgitation. A young woman underwent surveillance after cardiovascular magnetic resonance imaging demonstrated four equal cusps in diastole but bicuspid-type systolic opening from fusion of the left and non-coronary cusps. By 2025, eccentric regurgitation was severe on echocardiography and moderate-to-severe on magnetic resonance imaging, with a regurgitant fraction of 31% and mild left ventricular dilatation. Increasing breathlessness and declining peak oxygen uptake prompted multidisciplinary review. Valve replacement with ascending aortic support was recommended, and she was considered suitable for a Ross procedure with personalised external aortic root support.
Pre-Participation Echocardiographic Clue To Anomalous Aortic Origin Of The Left Anterior Descending Artery In An Endurance Athlete, Asterios Deligiannis, Maria Anifanti, Evangelia Kouidi
Pre-Participation Echocardiographic Clue To Anomalous Aortic Origin Of The Left Anterior Descending Artery In An Endurance Athlete, Asterios Deligiannis, Maria Anifanti, Evangelia Kouidi
Journal of the Hong Kong College of Cardiology
Anomalous aortic origin of a coronary artery may remain undetected during standard pre-participation cardiovascular screening. We report a 45-year-old asymptomatic marathon runner with normal physical examination and electrocardiogram. Transthoracic echocardiography showed a retroaortic tubular vascular structure with color flow, prompting coronary computed tomography angiography. Imaging demonstrated anomalous origin of the left anterior descending artery from the right sinus of Valsalva with an interarterial course and a coexisting retroaortic left circumflex artery. Functional and rhythm testing were reassuring. This case illustrates the potential incremental diagnostic value of echocardiography in selected athlete evaluations.
The C3-C3ar Axis Modulates Trained Immunity In Alveolar Macrophages, Alexander P Earhart, Rafael Aponte Alburquerque, Marick Starick, Lorena Garnica, Ayse Naz Ozanturk, Rahul Kumar Maurya, Xiaobo Wu, Jeffrey Haspel, Hrishikesh S Kulkarni, Et Al.
The C3-C3ar Axis Modulates Trained Immunity In Alveolar Macrophages, Alexander P Earhart, Rafael Aponte Alburquerque, Marick Starick, Lorena Garnica, Ayse Naz Ozanturk, Rahul Kumar Maurya, Xiaobo Wu, Jeffrey Haspel, Hrishikesh S Kulkarni, Et Al.
2020-Current year OA Pubs
Complement protein C3 is crucial for immune responses in mucosal sites such as the lung, where it aids in microbe elimination, and enhances inflammation. While trained immunity - enhanced secondary responses of innate immune cells after prior exposure - is well-studied, the role of the complement system in trained immune responses remains unclear. We investigated the role of C3 in trained immunity and found that alveolar macrophage (AM)
Proteomic Profiling Identifies Systemic Drivers Of Blood-Brain Barrier Injury In Sickle Cell Disease, Yan Wang, Serguei Astafiev, Jinsheng Yu, Slim Fellah, Martin N Reis, Vivian Chen, Amy E Mirro, Chunwei Ying, Kristin P Guilliams, Melanie E Fields, Allison A King, Yasheng Chen, Robert A Campbell, Jorge Di Paola, Carlos Cruchaga, Jin-Moo Lee, Hongyu An, Andria L Ford
Proteomic Profiling Identifies Systemic Drivers Of Blood-Brain Barrier Injury In Sickle Cell Disease, Yan Wang, Serguei Astafiev, Jinsheng Yu, Slim Fellah, Martin N Reis, Vivian Chen, Amy E Mirro, Chunwei Ying, Kristin P Guilliams, Melanie E Fields, Allison A King, Yasheng Chen, Robert A Campbell, Jorge Di Paola, Carlos Cruchaga, Jin-Moo Lee, Hongyu An, Andria L Ford
2020-Current year OA Pubs
Sickle cell disease (SCD) causes brain injury and cognitive disability. Systemic inflammation and endothelial injury are central to SCD pathophysiology, yet the relationship between systemic drivers of blood-brain barrier (BBB) disruption and brain injury remains understudied. This cross-sectional study assessed whole-brain and regional BBB permeability (Ktrans) using dynamic contrast-enhanced magnetic resonance imaging for 37 adults with SCD in steady state and 37 adults without SCD. Cerebral oxygen extraction fraction (OEF) and white matter mean diffusivity (MD) measured tissue hypoxia and microstructural injury, respectively. The SCD cohort showed elevated Ktrans compared with controls (3.6 × 10-4·min-1 vs 2.58 × 10-4·min-1; 95% …