Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Other

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type

Articles 8221 - 8250 of 25686

Full-Text Articles in Entire DC Network

Traumatic Ulcerative Granuloma With Stromal Eosinophilia (Tugse)-A Precursor Of Oral Squamous Cell Carcinoma?, Mathangi Kumar, Ravindranath Vineetha, Keerthilatha M. Pai, Abhay T. Kamath Jan 2020

Traumatic Ulcerative Granuloma With Stromal Eosinophilia (Tugse)-A Precursor Of Oral Squamous Cell Carcinoma?, Mathangi Kumar, Ravindranath Vineetha, Keerthilatha M. Pai, Abhay T. Kamath

Open Access archive

Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a benign, chronic, reactive and self-healing lesion. It is composed of abundant eosinophils and small lymphocytes. Several studies have shown varying observations on the relation of tissue eosinophilia with the prognosis of oral cancer. Here, we present a case of a 65-year-old male who presented with a non-healing ulcer on the lateral border of the tongue, which was suggestive of TUGSE on histopathological examination. The patient was kept on strict monthly follow up and the second re-biopsy was suggestive of moderately differentiated squamous cell carcinoma. Literature does not support the transformation of …

Go to article

Determining Language Production Abilities In Indian Adolescents Between 10 And 16 Years Of Age: Using A Conversational Based Task, Saniya Mariyam Rasheeka, Sudhin Karuppali, Megha Mohan Jan 2020

Determining Language Production Abilities In Indian Adolescents Between 10 And 16 Years Of Age: Using A Conversational Based Task, Saniya Mariyam Rasheeka, Sudhin Karuppali, Megha Mohan

Open Access archive

Objectives: Effective communication is an important part of social interaction significantly influenced by the mental states of communication partners. With the listener and the speaker constantly changing their thoughts and responding accordingly, a conversation is considered to be the most natural task to assess language production abilities. Therefore, the present study aimed to profile the language production abilities in Indian adolescents using a conversational based task. Methods: A total of 90 participants between 10 and 16 years of age were equally grouped into 6 groups. The research was conducted in three phases. Phase I included the development of the stimuli; …

Go to article

Global Injury Morbidity And Mortality From 1990 To 2017: Results From The Global Burden Of Disease Study 2017, Spencer L. James, Chris D. Castle, Zachary V. Dingels, Jack T. Fox Jan 2020

Global Injury Morbidity And Mortality From 1990 To 2017: Results From The Global Burden Of Disease Study 2017, Spencer L. James, Chris D. Castle, Zachary V. Dingels, Jack T. Fox

Open Access archive

Background Past research in population health trends has shown that injuries form a substantial burden of population health loss. Regular updates to injury burden assessments are critical. We report Global Burden of Disease (GBD) 2017 Study estimates on morbidity and mortality for all injuries. methods We reviewed results for injuries from the GBD 2017 study. GBD 2017 measured injury-specific mortality and years of life lost (YLLs) using the Cause of Death Ensemble model. To measure non-fatal injuries, GBD 2017 modelled injury-specific incidence and converted this to prevalence and years lived with disability (YLDs). YLLs and YLDs were summed to calculate …

Go to article

Improved Anomaly Detection Based On Integrated Multi-Scale Principal Component Analysis Using Wavelets: An Application To High Dimensional Processes, K. Ramakrishna Kini, Muddu Madakyaru Jan 2020

Improved Anomaly Detection Based On Integrated Multi-Scale Principal Component Analysis Using Wavelets: An Application To High Dimensional Processes, K. Ramakrishna Kini, Muddu Madakyaru

Open Access archive

Monitoring processes is becoming extremely crucial to maintain reliable and safe plant operation. Anomaly detection has proven to be easier through use of data driven methods that rely on historical data available from a process. Principal Component Analysis (PCA), a data-driven method, has been applied for detecting anomalies in industrial processes over last few decades. Since most processes are subjected to harsh environment, data collected is inherited with large amount of noise. Multi-scale filtering using wavelets has been well established for handling noisy data. In this paper, a new anomaly detection strategy which integrates multi-scale PCA(MS-PCA) and generalized likelihood ratio …

Go to article

The Impact Of Covid-19 On Price Volatility Of Crude Oil And Natural Gas Listed On Multi Commodity Exchange Of India, Bharat Kumar Meher, Iqbal Thonse Hawaldar, Latasha Mohapatra, Adel M. Sarea Jan 2020

The Impact Of Covid-19 On Price Volatility Of Crude Oil And Natural Gas Listed On Multi Commodity Exchange Of India, Bharat Kumar Meher, Iqbal Thonse Hawaldar, Latasha Mohapatra, Adel M. Sarea

Open Access archive

The impact of COVID-19, due to the wide-spread demand and supply destruction and downward movement of crude oil prices is of concern for all those connected with the oil and gas industry. In this study, an attempt has been made to estimate the price volatility of crude oil and natural gas listed on multi commodity exchange of India (MCX). We measured the leverage effect of COVID-19 on price volatility of crude oil and natural gas by using the daily prices of crude oil and natural gas from May 01, 2017 to April 30, 2020. The findings of the study reveal …

Go to article

Clinical Profile And Predictors Of Outcome In Spontaneous Intracerebral Hemorrhage From A Tertiary Care Centre In South India, Ajay Hegde, Girish Menon, Vinod Kumar, G. Lakshmi Prasad Jan 2020

Clinical Profile And Predictors Of Outcome In Spontaneous Intracerebral Hemorrhage From A Tertiary Care Centre In South India, Ajay Hegde, Girish Menon, Vinod Kumar, G. Lakshmi Prasad

Open Access archive

Background. This article attempts to evaluate the clinical profile and outcome determinants following hypertensive SICH in a South Indian population. The study represents the largest series of SICH reported from a single centre in India. Materials and Methods. Prospective data collection and analysis of patients with SICH admitted to our centre between 1st January 2015 and 31st December 2018. The variables analysed include: age, sex, comorbidities, Glasgow coma score (GCS) on admission, radiological features, treatment modality, and outcome at three months. Modified Rankin score (mRS) was used to assess the outcome at discharge and three months. Results. Our study group …

Go to article

Evaluating Pharmaceutical Marketing Knowledge And Attitude Among Medical Representative In Mumbai City: A Quantitative Study, Virendra Ligade, Juilee Bhegade Jan 2020

Evaluating Pharmaceutical Marketing Knowledge And Attitude Among Medical Representative In Mumbai City: A Quantitative Study, Virendra Ligade, Juilee Bhegade

Open Access archive

Medical representatives are important members of pharmaceutical companies. They are hired based on some specific criteria like basic knowledge about clinical, pharmaceutical marketing, and selling skills which are suitable to interact with healthcare providers. They provide drug's information to healthcare professionals and help pharmaceutical companies to generate the sales. After hiring for medical representative, companies provide training on many aspects. Along with scientific research knowledge, they often need to be updated and well versed with pharmaceutical marketing knowledge. For success of any medical representative, sound knowledge of pharmaceutical marketing is necessary. Knowledge and attitude regarding pharmaceutical marketing need to be …

Go to article

Salivary Mmp-9 As A Biomarker For The Diagnosis Of Oral Potentially Malignant Disorders And Oral Squamous Cell Carcinoma, Komal Smriti, Meenakshi Ray, Tilottama Chatterjee, Revathi Panduranga Shenoy Jan 2020

Salivary Mmp-9 As A Biomarker For The Diagnosis Of Oral Potentially Malignant Disorders And Oral Squamous Cell Carcinoma, Komal Smriti, Meenakshi Ray, Tilottama Chatterjee, Revathi Panduranga Shenoy

Open Access archive

Objective: To compare the salivary MMP - 9 concentration among subjects with oral squamous cell carcinoma (OSCC), oral potentially malignant disorders (OPMD), tobacco users, and control groups. Materials and methods: A total of 88 subjects were enrolled and divided into four study groups viz., OSCC (n=24), OPMD (n=20), tobacco habits (n=22), and healthy controls (n=22). All subjects gave unstimulated saliva samples for the evaluation MMP - 9 by ELISA kit. Demographic information like age, gender, type of tobacco, and duration of the habit were recorded. Results: Subjects with OSCC and OPMD had signifiantly higher mean MMP-9 levels than subjects with …

Go to article

Bullous Pemphigoid Triggered By Rabies Vaccine, Anuradha Jindal, Sudhir Nayak, Shrutakirthi Shenoi, Raghavendra Rao Jan 2020

Bullous Pemphigoid Triggered By Rabies Vaccine, Anuradha Jindal, Sudhir Nayak, Shrutakirthi Shenoi, Raghavendra Rao

Open Access archive

No abstract provided.

Go to article

Seroprevalence Of Lymes Disease In The Nagarahole And Bandipur Forest Areas Of South India, Kalpana Babu, Krishna Murthy, M. Bhagya, Praveen Murthy Jan 2020

Seroprevalence Of Lymes Disease In The Nagarahole And Bandipur Forest Areas Of South India, Kalpana Babu, Krishna Murthy, M. Bhagya, Praveen Murthy

Open Access archive

Purpose: The aim of this study was to determine the seroprevalence of Lymes disease in a population at risk in south India. Methods: Prospective ongoing study and included screening of forest workers and staff of Nagarahole and Bandipur forest ranges in South India for Lymes disease. Screening included a detailed questionnaire for Lymes disease, complete ocular and systemic examination by an ophthalmologist and infectious disease specialist and blood collection. ELISA for IgM and IgG antibodies for Borrelia burgdorferi were performed on the collected sera samples. Western blot confirmation was done on the seropositive samples. Ticks were also collected from these …

Go to article

Mucinous Tubular And Spindle Cell Carcinoma A Review Of Histopathology And Clinical And Prognostic Implications, Shrinidhi Nathany, Vidya Monappa Jan 2020

Mucinous Tubular And Spindle Cell Carcinoma A Review Of Histopathology And Clinical And Prognostic Implications, Shrinidhi Nathany, Vidya Monappa

Open Access archive

Mucinous tubular and spindle cell carcinomas are rare kidney tumors with generally indolent behavior. As the name suggests, classic histomorphology reveals bland spindle cells, tubules, and mucinous stroma. Uncommon histologic features include mucin-poor stroma, high nuclear grade, cellular pleomorphism, and presence of necrosis. Rare cases can show aggressive growth and distant metastasis. Mucinous tubular and spindle cell carcinoma has characteristic chromosomal abnormalities and the molecular signature remains the same, irrespective of the varied histomorphology.

Go to article

Comparative Evaluation Of Fluoride Release From Two Different Glass Ionomer Cement And A Novel Alkasite Restorative Material – An In Vitro Study, Harpreet Singh, Shashi Acharya Rashmi, Swathi Pai, Sandya Kini Jan 2020

Comparative Evaluation Of Fluoride Release From Two Different Glass Ionomer Cement And A Novel Alkasite Restorative Material – An In Vitro Study, Harpreet Singh, Shashi Acharya Rashmi, Swathi Pai, Sandya Kini

Open Access archive

Objective: To compare the fluoride release from Conventional Glass Ionomer Cement (GIC), Resin Modified GIC (RMGIC), and Cention N Alkasite Material. Material and Methods: Forty-five disc-shaped specimens of three different restorative materials (Conventional GIC, RMGIC, and Alkasite material) were made and divided into 3 groups (n=15). Fluoride release was evaluated at the end of Day 1, 7, 14, and Day 28 using fluoride ion-selective electrode. Intergroup and Intra-group analysis was done using One-way ANOVA with a Post-hoc test. A p-value of <0.05 was considered statistically significant. Results: Cention showed more fluoride release (in parts per million) than GIC and RMGIC at increased time duration. However, at the end of day 1, there was lesser fluoride release with Cention, as compared with the other groups. Conclusion: The new Alkasite restorative material showed promising results in terms of fluoride release and is better than GIC and RMGIC at increased time duration.

Go to article

Aberrant Lipid Metabolism As An Emerging Therapeutic Strategy To Target Cancer Stem Cells, Malini Visweswaran, Frank Arfuso, Sudha Warrier, Arun Dharmarajan Jan 2020

Aberrant Lipid Metabolism As An Emerging Therapeutic Strategy To Target Cancer Stem Cells, Malini Visweswaran, Frank Arfuso, Sudha Warrier, Arun Dharmarajan

Open Access archive

Emerging evidence in cancer metabolomics has identified reprogrammed metabolic pathways to be a major hallmark of cancer, among which deregulated lipid metabolism is a prominent field receiving increasing attention. Cancer stem cells (CSCs) comprise <0.1% of the tumor bulk and possess high self-renewal, tumor-initiating properties, and are responsible for therapeutic resistance, disease recurrence, and tumor metastasis. Hence, it is imperative to understand the metabolic rewiring occurring in CSCs, especially their lipid metabolism, on which there have been recent reports. CSCs rely highly upon lipid metabolism for maintaining their stemness properties and fulfilling their biomass and energy demands, ultimately leading to cancer growth and invasion. Hence, in this review we will shed light on the aberrant lipid metabolism that CSCs exploit to boost their survival, which comprises upregulation in de novo lipogenesis, lipid droplet synthesis, lipid desaturation, and β-oxidation. Furthermore, the metabolic regulators involved in the process, such as key lipogenic enzymes, are also highlighted. Finally, we also summarize the therapeutic strategies targeting the key regulators involved in CSCs' lipid metabolism, which thereby demonstrates the potential to develop powerful and novel therapeutics against the CSC lipid metabolome.

Go to article

Classification Of Fever Patterns Using A Single Extracted Entropy Feature: A Feasibility Study Based On Sample Entropy, David Cuesta-Frau, Pau Miró-Martínez, Sandra Oltra-Crespo, Antonio Molina-Picó Jan 2020

Classification Of Fever Patterns Using A Single Extracted Entropy Feature: A Feasibility Study Based On Sample Entropy, David Cuesta-Frau, Pau Miró-Martínez, Sandra Oltra-Crespo, Antonio Molina-Picó

Open Access archive

Fever is a common symptom of many diseases. Fever temporal patterns can be different depending on the specific pathology. Differentiation of diseases based on multiple mathematical features and visual observations has been recently studied in the scientific literature. However, the classification of diseases using a single mathematical feature has not been tried yet. The aim of the present study is to assess the feasibility of classifying diseases based on fever patterns using a single mathematical feature, specifically an entropy measure, Sample Entropy. This was an observational study. Analysis was carried out using 103 patients, 24 hour continuous tympanic temperature data. …

Go to article

Performance Analysis Of Binary And Multiclass Models Using Azure Machine Learning, Smitha Rajagopal, Katiganere Siddaramappa Hareesha, Poornima Panduranga Kundapur Jan 2020

Performance Analysis Of Binary And Multiclass Models Using Azure Machine Learning, Smitha Rajagopal, Katiganere Siddaramappa Hareesha, Poornima Panduranga Kundapur

Open Access archive

Network data is expanding and that too at an alarming rate. Besides, the sophisticated attack tools used by hackers lead to capricious cyber threat landscape. Traditional models proposed in the field of network intrusion detection using machine learning algorithms emphasize more on improving attack detection rate and reducing false alarms but time efficiency is often overlooked. Therefore, in order to address this limitation, a modern solution has been presented using Machine Learning-as-a-Service platform. The proposed work analyses the performance of eight two-class and three multiclass algorithms using UNSW NB-15, a modern intrusion detection dataset. 82,332 testing samples were considered to …

Go to article

Effect Of Coffee Constituents, Caffeine And Caffeic Acid On Anxiety And Lipopolysaccharide-Induced Sickness Behavior In Mice, Jayesh Mudgal, Sanchari Basu Mallik, Madhavan Nampoothiri, Manas Kinra Jan 2020

Effect Of Coffee Constituents, Caffeine And Caffeic Acid On Anxiety And Lipopolysaccharide-Induced Sickness Behavior In Mice, Jayesh Mudgal, Sanchari Basu Mallik, Madhavan Nampoothiri, Manas Kinra

Open Access archive

Caffeine (CAF) and polyphenolic compounds like caffeic acid (CA), chlorogenic acid and ferulic acid are commonly consumed through beverages and food. These constituents modulate immune system and impact the systemic inflammatory pathways. This study explored the modulatory effect of CA and CA + CAF on behavior and lipopolysaccharide (LPS) – induced neuroinflammation in mice. An array of behavioral tests suggest that CA (15 mg/kg) and CA + CAF (10 mg/kg + 5 mg/kg) express anxiolytic-like properties. Systemic administration of LPS (1.5 mg/kg) induced profound immobility, increased the systemic/brain cytokine (TNF-α and IL-6) levels and altered the host antioxidant defence in …

Go to article

Automated Fundus Image Quality Assessment And Segmentation Of Optic Disc Using Convolutional Neural Networks, Bhargav Bhatkalkar, Abhishek Joshi, Srikanth Prabhu, Sulatha Bhandary Jan 2020

Automated Fundus Image Quality Assessment And Segmentation Of Optic Disc Using Convolutional Neural Networks, Bhargav Bhatkalkar, Abhishek Joshi, Srikanth Prabhu, Sulatha Bhandary

Open Access archive

An automated fundus image analysis is used as a tool for the diagnosis of common retinal diseases. A good quality fundus image results in better diagnosis and hence discarding the degraded fundus images at the time of screening itself provides an opportunity to retake the adequate fundus photographs, which save both time and resources. In this paper, we propose a novel fundus image quality assessment (IQA) model using the convolutional neural network (CNN) based on the quality of optic disc (OD) visibility. We localize the OD by transfer learning with Inception v-3 model. Precise segmentation of OD is done using …

Go to article

Security Framework For Cloud Based Electronic Health Record (Ehr) System, Raghavendra Ganiga, Radhika M. Pai, M. M. Manohara Pai, Rajesh Kumar Sinha Jan 2020

Security Framework For Cloud Based Electronic Health Record (Ehr) System, Raghavendra Ganiga, Radhika M. Pai, M. M. Manohara Pai, Rajesh Kumar Sinha

Open Access archive

Health records are an integral aspect of any Hospital Management System. With newer innovations in technology, there has been a shift in the way of recording health information. Medical records which used to be managed using various paper charts have now become easier to organize and maintain, thereby increasing the efficiency of medical staff. The Electronic Health Records (EHR) System is becoming a high-tech medical management technology developed for the economic or emerging economic countries like India. In a national health system, the EHR integrates the Electronic Medical Records (EMR) in all collaborating hospitals through different networks. EHR gives healthcare …

Go to article

Extra-Cellular Vesicles Carry Proteome Of Cancer Hallmarks, Ana Sofia Carvalho, Henrique Baeta, Bruno Costa Silva, Maria Carolina Strano Moraes Jan 2020

Extra-Cellular Vesicles Carry Proteome Of Cancer Hallmarks, Ana Sofia Carvalho, Henrique Baeta, Bruno Costa Silva, Maria Carolina Strano Moraes

Open Access archive

Through lateral transfer, extra-cellular vesicles (EVs) transport their DNA, miRNA, mRNA and proteins such as enzymes mediating drug resistance, transporters as well as growth factors to neighboring cells. By virtue of this horizontal transfer, EVs potentially regulate cell growth, migration, angiogenesis and metastasis and increase tissue permeability in cancer. Furthermore, EVs regulate immune factors and allow the tumor cells to evade immune recognition and cell death. To explore if the proteomes of exosomes support functional transfer of cancer hallmarks, in this meta-analysis, we compared EVs and whole cell proteomes from the NCI-60 human tumor cell line panel. We observed a …

Go to article

Promoting Patient Utilization Of Outpatient Cardiac Rehabilitation: A Joint International Council And Canadian Association Of Cardiovascular Prevention And Rehabilitation Position Statement, Carolina Santiago De Araújo Pio, Theresa M. Beckie, Marlien Varnfield, Nizal Sarrafzadegan Jan 2020

Promoting Patient Utilization Of Outpatient Cardiac Rehabilitation: A Joint International Council And Canadian Association Of Cardiovascular Prevention And Rehabilitation Position Statement, Carolina Santiago De Araújo Pio, Theresa M. Beckie, Marlien Varnfield, Nizal Sarrafzadegan

Open Access archive

Background: Cardiac Rehabilitation (CR) is a recommendation in international clinical practice guidelines given its' benefits, however use is suboptimal. The purpose of this position statement was to translate evidence on interventions that increase CR enrolment and adherence into implementable recommendations. Methods: The writing panel was constituted by representatives of societies internationally concerned with preventive cardiology, and included disciplines that would be implementing the recommendations. Patient partners served, as well as policy-makers. The statement was developed in accordance with AGREE II, among other guideline checklists. Recommendations were based on our update of the Cochrane review on interventions to promote patient utilization …

Go to article

Circulating Tumor Cells As An Emerging Tool In Cancer Therapy, Ajay Balakrishnan, Irene A. George, Prashant Kumar Jan 2020

Circulating Tumor Cells As An Emerging Tool In Cancer Therapy, Ajay Balakrishnan, Irene A. George, Prashant Kumar

Open Access archive

Majority of the cancer-related deaths are related to metastasis during which cancer cells invade the surrounding tissues, enter (intravasation) and exit (extravasation) the peripheral circulation and seed distant organs. The Circulating Tumor Cells (CTCs) exist in peripheral blood as single cells or as oligoclonal clusters of tumor cells along with platelets and lymphocytes. Detection of CTCs allows characterizing the tumors by their genotype and in predicting the prognosis and response to therapy and explants derived from these cells can be used in drug screening. In this review, we highlight the methods used for isolation and culture of CTCs and their …

Go to article

Innovative Intraoperative Splints For Tendon Transfer Procedures, Jagannath B.N. Kamath, Arkesh Madegowda, Premjith Sujir, Mithun Pai Jan 2020

Innovative Intraoperative Splints For Tendon Transfer Procedures, Jagannath B.N. Kamath, Arkesh Madegowda, Premjith Sujir, Mithun Pai

Open Access archive

Tendon transfers are well accepted treatment modality for managing difficult neurological and musculo tendinous deficits of upper and lower extremities. The most important technical consideration in the final outcome of these procedures are the tension and position with which the donor tendon is attached to the recipient tendon. This technical aspect of the procedure has not been given due importance in the literature. We the authors share our experience of fabricating intra operative splints for various tendon transfer procedures using easily available components of external fixator.

Go to article

Exome Sequencing Reveals A Novel Splice Site Variant In Huwe1 Gene In Patients With Suspected Say-Meyer Syndrome, Babylakshmi Muthusamy, Thong T. Nguyen, Aravind K. Bandari, Salah Basheer Jan 2020

Exome Sequencing Reveals A Novel Splice Site Variant In Huwe1 Gene In Patients With Suspected Say-Meyer Syndrome, Babylakshmi Muthusamy, Thong T. Nguyen, Aravind K. Bandari, Salah Basheer

Open Access archive

Say-Meyer syndrome is a rare and clinically heterogeneous syndrome characterized by trigonocephaly, short stature, developmental delay and hypotelorism. Nine patients with this syndrome have been reported thus far although no causative gene has yet been identified. Here, we report two siblings with clinical phenotypes of Say-Meyer syndrome with moderate to severe intellectual disability and autism spectrum disorder. Cytogenetics and array-based comparative genomic hybridization did not reveal any chromosome abnormalities or copy number alterations. Exome sequencing of the patients revealed a novel X-linked recessive splice acceptor site variant c.145-2A > G in intron 5 of HUWE1 gene in both affected siblings. RT-PCR …

Go to article

Integrative Phosphoproteome And Interactome Analysis Of The Role Of Ubash3b In Bcr-Abl Signaling, Jevon A. Cutler, Savita Udainiya, Anil K. Madugundu, Santosh Renuse Jan 2020

Integrative Phosphoproteome And Interactome Analysis Of The Role Of Ubash3b In Bcr-Abl Signaling, Jevon A. Cutler, Savita Udainiya, Anil K. Madugundu, Santosh Renuse

Open Access archive

No abstract provided.

Go to article

How Does Context Influence Arm Use After Stroke? A Qualitative Content Analysis Among Rural Community-Dwelling Stroke Survivors, Vasanthan Rajagopalan, Manikandan Natarajan, Johnson Alex, John M. Solomon Jan 2020

How Does Context Influence Arm Use After Stroke? A Qualitative Content Analysis Among Rural Community-Dwelling Stroke Survivors, Vasanthan Rajagopalan, Manikandan Natarajan, Johnson Alex, John M. Solomon

Open Access archive

Objective: To explore the personal and environmental contextual factors that influence use of affected arm for function among stroke survivors. Methods: We conducted a qualitative phenomenological study using an interpretivist paradigm among 23 stroke survivors in their late sub-acute and chronic stages and their relatives living in the rural regions of India using maximum variation sampling. Semi-structured interviews were conducted to identify personal and environmental contextual factors relevant to arm use. Their current level of arm use, motor and functional ability were evaluated using Motor Activity Log, AbilHand and Lawton Instrumental Activities of Daily Living scales and the scores were …

Go to article

Surface Roughness Analysis In The Drilling Of Carbon Fiber/Epoxy Composite Laminates Using Hybrid Taguchi-Response Experimental Design, S. M. Shahabaz, Nagaraja Shetty, S. Divakara Shetty, S. S. Sharma Jan 2020

Surface Roughness Analysis In The Drilling Of Carbon Fiber/Epoxy Composite Laminates Using Hybrid Taguchi-Response Experimental Design, S. M. Shahabaz, Nagaraja Shetty, S. Divakara Shetty, S. S. Sharma

Open Access archive

The carbon fiber reinforced polymer composite has made a substantial impact on the manufacturing sectors owing to its excellent mechanical, thermal and corrosion resisting properties. The surface roughness mainly depends on the machining parameters while drilling of carbon fiber reinforced polymer composite laminates. The study concentrates on the impact of uncoated and titanium nitride coated solid carbide drills on minimizing the roughness that is generated while making holes in bi-directional carbon fiber reinforced polymer composite by optimizing the drilling constraints [spindle speed (A), feed rate (B), point angle (C) and drill diameter (D)]. Experimental studies are carried out using Taguchi …

Go to article

The Pax-Six-Eya-Dach Network Modulates Gata-Fog Function In Fly Hematopoiesis And Human Erythropoiesis, T. Michael Creed, Rajkumar Baldeosingh, Christian L. Eberly, Caroline S. Schlee Jan 2020

The Pax-Six-Eya-Dach Network Modulates Gata-Fog Function In Fly Hematopoiesis And Human Erythropoiesis, T. Michael Creed, Rajkumar Baldeosingh, Christian L. Eberly, Caroline S. Schlee

Open Access archive

The GATA and PAX-SIX-EYA-DACH transcriptional networks (PSEDNs) are essential for proper development across taxa. Here, we demonstrate novel PSEDN roles in vivo in Drosophila hematopoiesis and in human erythropoiesis in vitro. Using Drosophila genetics, we show that PSEDN members function with GATA to block lamellocyte differentiation and maintain the prohemocyte pool. Overexpression of human SIX1 stimulated erythroid differentiation of human erythroleukemia TF1 cells and primary hematopoietic stem-progenitor cells. Conversely, SIX1 knockout impaired erythropoiesis in both cell types. SIX1 stimulation of erythropoiesis required GATA1, as SIX1 overexpression failed to drive erythroid phenotypes and gene expression patterns in GATA1 knockout cells. SIX1 …

Go to article

Multiclass Queueing Network Modeling And Traffic Flow Analysis For Sdn-Enabled Mobile Core Networks With Network Slicing, Santhosha Kamath, Sanjay Singh, M. Sathish Kumar Jan 2020

Multiclass Queueing Network Modeling And Traffic Flow Analysis For Sdn-Enabled Mobile Core Networks With Network Slicing, Santhosha Kamath, Sanjay Singh, M. Sathish Kumar

Open Access archive

The back-haul networks of 5G are formed by heterogeneous links which need to handle massive traffic. The service providers are not able to provide good QoS for their users. The technology like Software Defined Networks(SDN) and Network Slicing helps a little for a service provider to providing QoS for multiple links. The service providers face a challenge in the efficient utilization of resources to fulfill the QoS requirement of users to comply with the growth and thereby increasing the revenue. These problems require an accurate traffic model to determine the steady-state of the system. The proposed model uses an architecture …

Go to article

Mapping The Micro-Proteome Of The Nuclear Lamina And Lamina-Associated Domains, Xianrong Wong, Jevon A. Cutler, Victoria E. Hoskins, Molly Gordon Jan 2020

Mapping The Micro-Proteome Of The Nuclear Lamina And Lamina-Associated Domains, Xianrong Wong, Jevon A. Cutler, Victoria E. Hoskins, Molly Gordon

Open Access archive

The nuclear lamina is a proteinaceous network offilaments that provide both structural and gene regulatory functions by tethering proteins and large domains of DNA, the so-called lamina-associated domains (LADs), to the periphery of the nucleus. LADs are a large fraction of the mammalian genome that are repressed, in part, by their association to the nuclear periphery. The genesis and maintenance of LADs is poorly understood as are the proteins that participate in these functions. In an effort to identify proteins that reside at the nuclear periphery and potentially interact with LADs, we have taken a two-pronged approach. First, we have …

Go to article

Influence Of Stacking Sequence On The Mechanical Properties Of 3d E-Glass/Bamboo Non-Woven Hybrid Epoxy Composites, Suhas Yeshwant Nayak, B. Satish Shenoy, Mohamed Thariq Bin Hameed Sultan, Chandrakant R. Kini Jan 2020

Influence Of Stacking Sequence On The Mechanical Properties Of 3d E-Glass/Bamboo Non-Woven Hybrid Epoxy Composites, Suhas Yeshwant Nayak, B. Satish Shenoy, Mohamed Thariq Bin Hameed Sultan, Chandrakant R. Kini

Open Access archive

Hybridization of composites is one of the many ways to optimize cost, manufacturing process and strength required for a particular application. This demands a need for knowledge about the best possible ways to deal with the dissimilar materials in the composite system. Very little light has been shed about the stacking sequence implemented while dealing with non-woven natural fiber mats and 3D woven glass fiber fabric as reinforcement and effects of different models on the strength of composite - which has been dealt very vividly in this research work. Two types of hybrid stacking sequence were implemented using non-woven bamboo …

Go to article

First Prev Next Last