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Solid Dosage Forms: A Detailed Research On Non-Conforming Product Quality, G. Katta Hemanth, U. Ravindra Shenoy, Girish Thunga, Sudeep Kumar Agrawal Jul 2020

Solid Dosage Forms: A Detailed Research On Non-Conforming Product Quality, G. Katta Hemanth, U. Ravindra Shenoy, Girish Thunga, Sudeep Kumar Agrawal

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Introduction: Any defects in pharmaceutical products lead to minor, major, or critical deviation and if such a product is released, it also leads to product recalls and legal actions. In such cases, the concern is about patient’s safety rather than the company’s economy and fame. This study aimed to investigate the various quality defects which have occurred in marketed tablets. Materials and Methods: The investigation was carried out which involved identification of defects, categorizing the type, root causes, suggesting remedial measures and documenting the clinical significance of defective dosage forms of tablets. Dosage forms included were film-coated tablets, uncoated tablets, …

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Novel Validated Uv Spectroscopic Method For Routine Analysis Of Decitabine Drug Substance, Ankit Awasthi, H. M. Dheeraj, Muddukrishna Badamane Sathyanarayana Jul 2020

Novel Validated Uv Spectroscopic Method For Routine Analysis Of Decitabine Drug Substance, Ankit Awasthi, H. M. Dheeraj, Muddukrishna Badamane Sathyanarayana

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Objectives: In the proposed study, a basic, novel, protected economic, delicate and cost-effective UV-Spectrophotometric technique for the analysis of Decitabine which is antineoplastic drug. Methods: The created method was approved according to ICH rules. The decitabine indicated maximum absorption at 221 nm. This strategy can successfully apply for estimation of Decitabine in active pharmaceutical ingredient (API) form for routine examination with UV identification at 221 nm. A Shimadzu UV-Visible spectrophotometer 1800 with 1 cm quartz cells and Acetonitrile (ACN) as diluent was utilized in this technique. Results: The Developed technique obeyed Beer's-Lambert's law in the conc. of 5.0-15.0 ug/ml, having …

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Mycotic Keratitis Due To Cylindrocarpon Lichenicola: Successful Salvage Of The Eye, M. Suchitra Shenoy, Rajesh R. Nayak, Vijay Pai, K. Archana Bhat Jul 2020

Mycotic Keratitis Due To Cylindrocarpon Lichenicola: Successful Salvage Of The Eye, M. Suchitra Shenoy, Rajesh R. Nayak, Vijay Pai, K. Archana Bhat

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We hereby report a successfully salvaged eye due to mycotic keratitis by Cylindrocarpon lichenicola in a 60-year-old female from Kasaragod (Kerala). The patient came with a history of pain, photophobia and decreased vision of the right eye. The microbiological investigations of the corneal scraping revealed C. lichenicola. C. lichenicola is a soil saprophyte. Since the ulcer worsened paracentesis followed by therapeutic keratoplasty and adjunct therapy with natamycin drops, voriconazole drops and oral ketoconazole was given. We stress that evidence-based timely medical and surgical intervention helped in the restoration of the vision in an infected eye.

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Influence Of Air Gap Under Bolus In The Dosimetry Of A Clinical 6 Mv Photon Beam, Dilson Lobo, Sourjya Banerjee, Challapalli Srinivas, Ramamoorthy Ravichandran Jul 2020

Influence Of Air Gap Under Bolus In The Dosimetry Of A Clinical 6 Mv Photon Beam, Dilson Lobo, Sourjya Banerjee, Challapalli Srinivas, Ramamoorthy Ravichandran

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Aim: In some situations of radiotherapy treatments requiring application of tissue-equivalent bolus material (e.g., gel bolus), due to material's rigid/semi-rigid nature, undesirable air gaps may occur beneath it because of irregularity of body surface. The purpose of this study was to evaluate the dosimetric parameters such as surface dose (Ds), depth of dose maximum (dmax), and depth dose along central axis derived from the percentage depth dose (PDD) curve of a 6 MV clinical photon beam in the presence of air gaps between the gel bolus and the treatment surface. Materials and Methods: A bolus holder was designed to hold …

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An Anatomical Perspective Of Ulnar Collateral Nerve With Reference To Nerve And Muscle Transfer Surgery, P. J. Jiji, T. Joy, B. V. Murlimanju, M. M. Pai Jul 2020

An Anatomical Perspective Of Ulnar Collateral Nerve With Reference To Nerve And Muscle Transfer Surgery, P. J. Jiji, T. Joy, B. V. Murlimanju, M. M. Pai

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Background. The purpose was to analyze the prevalence, origin, course and termination of the ulnar collateral nerve in anatomical samples from Indian population. Methods. The present study included 68 adult human cadaveric embalmed upper limbs. The sex of these upper limbs were not known. The initial segment of radial nerve was meticulously dissected in the specimens to observe the ulnar collateral nerve. The digital Vernier caliper was used for the measurements which were performed in this study. The data was given in millimeter and expressed as mean ± SD. Results. The ulnar collateral nerve was observed in 57 (83.8%) of …

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Respiratory Muscle Function And Exercise Capacity In A Stage 4 Head And Neck Cancer Patient Receiving Chemoradiotherapy, Macrina D'Souza, Stephen Rajan Samuel, Santosh P.V. Rai, P. U. Prakash Saxena Jul 2020

Respiratory Muscle Function And Exercise Capacity In A Stage 4 Head And Neck Cancer Patient Receiving Chemoradiotherapy, Macrina D'Souza, Stephen Rajan Samuel, Santosh P.V. Rai, P. U. Prakash Saxena

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Background: Reduced physical and functional capacity is one of the main treatment-related side effects of chemoradiation therapy in head-and-neck cancer patients. We evaluated a case of a head-and-neck cancer patient who was undergoing chemoradiation and was assessed for various components of cardiopulmonary function that plays a vital role in the treatment prognosis. The aim of this case report was to evaluate the respiratory muscle function and exercise capacity of a head-and-neck cancer patient receiving chemoradiation therapy. Settings and Design: From among the newly diagnosed admitted to the hospital care, a 60-year-old male with supraglottic carcinoma, who was undergoing concomitant chemoradiation …

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The Case For Palliative Medicine In The Emergency Medicine Department - The Time Is Now!, William Wilson Jul 2020

The Case For Palliative Medicine In The Emergency Medicine Department - The Time Is Now!, William Wilson

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No abstract provided.

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An Uncommon Case Of Isolated Superior Rectus Palsy, Teena Mariet Mendonca, K. Suprasanna, Gladys R. Rodrigues, Shobha G. Pai Jul 2020

An Uncommon Case Of Isolated Superior Rectus Palsy, Teena Mariet Mendonca, K. Suprasanna, Gladys R. Rodrigues, Shobha G. Pai

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Head injury associated with orbital trauma is commonly encountered in day-to-day practice. We report a rare case of orbital trauma resulting in isolated orbital roof blow in fracture in a 14-year-old child. The patient presented to us with diplopia and limitation of elevation of right eye after orbital trauma. Computed tomography of the orbits (2 mm sections) did not reveal fracture of the orbital floor. However, there was orbital roof blow in fracture with fracture fragment impingement on the superior rectus muscle. Patient was treated conservatively and spontaneous recovery of ocular motility was noted after a month.

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Detection Of Biofilm Production And Its Impact On Antibiotic Resistance Profile Of Bacterial Isolates From Chronic Wound Infections, Kala Harika, Vishnu Shenoy, Nagalakshmi Narasimhaswamy, Kiran Chawla Jul 2020

Detection Of Biofilm Production And Its Impact On Antibiotic Resistance Profile Of Bacterial Isolates From Chronic Wound Infections, Kala Harika, Vishnu Shenoy, Nagalakshmi Narasimhaswamy, Kiran Chawla

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Background: Microorganisms are known to be involved in the formation of biofilm. These biofilms are often seen in chronic wound infections, surgical site infections, implants etc., These are capable of causing recalcitrant infections and most of them are also known to possess high antibiotic resistance. Objectives: This study was conducted to detect the biofilm formation in bacterial isolates from chronic wound infections. Materials and Methods: In the present study, ninety two isolates from chronic wound infections were identified by MALDI-TOF-MS (bioMerieux) and VITEK-2-MS (bioMerieux). These isolates were further screened for biofilm formation by three methods i. e., Tissue Culture Plate …

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Diagnostic Dilemma Of A Thumb Swelling: An Unpropitious Turn Of Events, Seetharama Rao, Pooja Suresh, Merwyn Fernandes, Laxman Prabhu Jul 2020

Diagnostic Dilemma Of A Thumb Swelling: An Unpropitious Turn Of Events, Seetharama Rao, Pooja Suresh, Merwyn Fernandes, Laxman Prabhu

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Benign and malignant bone tumors arise in small bones of the hands and feet. Nevertheless, secondary deposits at these sites are extremely rare. We report a peculiar case of an adult man who presented with thumb swelling, which was later discovered to be a metastasis from renal cell carcinoma. Such cases have a sinister prognosis with a survival rate of 6-12 months from the time of diagnosis. We intend to discuss the diagnostic dilemma and treatment of acrometastases.

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Application Of Predictive Modelling To Improve The Discharge Process In Hospitals, Sayed Hisham, Shahina Abdul Rasheed, Brayal Dsouza Jul 2020

Application Of Predictive Modelling To Improve The Discharge Process In Hospitals, Sayed Hisham, Shahina Abdul Rasheed, Brayal Dsouza

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Objectives: To find out the factors influencing discharge process turnaround time (TAT) and to accurately predict the discharge process TAT. Methods: The discharge process of cardiology department inpatients in a tertiary care hospital was mapped over a month. The likely factors influencing discharge TAT were tested for significance by ANOVA. Multiple linear regression (MLR) was used to predict the TAT. The sample was divided into testing and training sets for regression. A model was generated using the training set and compared with the testing set for accuracy. Results: After a process map was plot-ted, the significant factors influencing the TAT …

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Wildlife Collisions To Aircraft In India-A Comparative Analysis Of Hazardous Species Involved In Different Time Periods, S. Srinidhi, P. Pramod, Yamini Singh, Sayar Singh Jul 2020

Wildlife Collisions To Aircraft In India-A Comparative Analysis Of Hazardous Species Involved In Different Time Periods, S. Srinidhi, P. Pramod, Yamini Singh, Sayar Singh

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Wildlife strikes (mainly birds, but also includes bats and other mammals on the ground) with aircraft is a serious economic and safety concern in the aviation industry. The solution to the problem can be evolved by identifying the species involved in the incidents/ accidents. In the Indian context, such an attempt was started in 1980. In the recent past, Indian Air Force adopted the DNA Bar-coding technology to identify the species involved. The extent of the problems faced by the country and involvement of different species in various time blocks has been compared with an objective of analysing changes over …

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Performance Analysis Of A Fuzzy Disparity Selector For Stereo Matching Of Image Segments Under Radiometric Variations, Akhil Appu Shetty, Vadakekara Itty George, Chempi Gurudas Nayak, Raviraj Shetty Jul 2020

Performance Analysis Of A Fuzzy Disparity Selector For Stereo Matching Of Image Segments Under Radiometric Variations, Akhil Appu Shetty, Vadakekara Itty George, Chempi Gurudas Nayak, Raviraj Shetty

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Stereo matching algorithms generate disparity maps, which contain the depth information of the environment, from two or more images of a scene taken from different viewpoints. The process of obtaining dense disparity maps is a problem which is still being actively researched. The presence of radiometric differences in the images only further complicates the stereo matching problem. In the present research work, the images are initially split into small patches of pixels, such that pixels in each patch have similar intensities. The authors attempt to study the effect of the parameters, namely, tuning parameter 'α' and the number of segments, …

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A Learner Centered Approach Of Teaching And Learning In Pharmacology: A Questionnaire Based Analysis Of Student Cognizance And Experiences, Rashmi Raghava Rao, Preethi Jnaneshwara Shenoy, Sheetal Dinakar Ullal, Ashwin Kamath Jul 2020

A Learner Centered Approach Of Teaching And Learning In Pharmacology: A Questionnaire Based Analysis Of Student Cognizance And Experiences, Rashmi Raghava Rao, Preethi Jnaneshwara Shenoy, Sheetal Dinakar Ullal, Ashwin Kamath

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Background: Innovative and flexible educational methods like Problem Based Learning (PBL) and integrated teaching practices were integrated into the Pharmacology course in a manner that they complement the didactic lectures or, completely replace the lecture classes with the aim to optimize the educational atmosphere for a better learner experience. Aim: The present study is an attempt to gather feedback on newer teaching learning methods and audiovisual aids employed during the didactic lectures and small group teaching sessions newly introduced into the curriculum. Methods: The study is a cross sectional questionnaire-based analysis. The questionnaires were distributed to the second-year medical students …

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Guidelines For Various Laboratory Sections In View Of Covid-19: Recommendations From The Indian Association Of Pathologists And Microbiologists, Vatsala Misra, Ranjan Agrawal, Harendra Kumar, Asaranti Kar Jul 2020

Guidelines For Various Laboratory Sections In View Of Covid-19: Recommendations From The Indian Association Of Pathologists And Microbiologists, Vatsala Misra, Ranjan Agrawal, Harendra Kumar, Asaranti Kar

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Declared as a pandemic by WHO on March 11, 2020, COVID-19 has brought about a dramatic change in the working of different laboratories across the country. Diagnostic laboratories testing different types of samples play a vital role in the treatment management. Irrespective of their size, each laboratory has to follow strict biosafety guidelines. Different sections of the laboratory receive samples that are variably infectious. Each sample needs to undergo a proper and well-designed processing system so that the personnel involved are not infected and also their close contacts. It takes a huge effort so as to limit the risk of …

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Prakriti Phenotypes As A Stratifier Of Gut Microbiome: A New Frontier In Personalized Medicine?, Apoorva Jnana, Thokur Sreepathy Murali, Kanive Parashiva Guruprasad, Kapaettu Satyamoorthy Jul 2020

Prakriti Phenotypes As A Stratifier Of Gut Microbiome: A New Frontier In Personalized Medicine?, Apoorva Jnana, Thokur Sreepathy Murali, Kanive Parashiva Guruprasad, Kapaettu Satyamoorthy

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Ayurveda has a rich history and its significance woven deeply in the Indian culture. The concept of prakriti (a person's “nature” or constitutional type determined by the proportion of three doshas, namely - vata, pitta and kapha) in Ayurveda is deeply rooted in personalized health management. While the attributes of prakriti has been established to have a genomic basis, there is dearth of elaborate evidences linking prakriti with manifestation of diseases. Next generation sequencing studies have provided a causal link between variation in the gut microbiome and its effect on an individual's fitness. Separately, reports have identified gut microbial patterns …

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Evidence-Based Medicine Databases: An Overview, Viji Pulikkel Chandran, Sohil Khan, Girish Pai Kulyadi, Kanav Khera Jul 2020

Evidence-Based Medicine Databases: An Overview, Viji Pulikkel Chandran, Sohil Khan, Girish Pai Kulyadi, Kanav Khera

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Evidence-based medicine (EBM) helps to bridge the gap between current healthcare practice and recent research findings in health care. Today's era of scientific information explosion makes hard for healthcare providers to remain up to date on the best clinical practices. In reality, a physician has to read 17 scientific literature works per day to remain up to date. This is a difficult challenge, but EBM databases provide quick access to research findings. This review aims to provide an overview of EBM databases. These databases provide information about guidelines, disease, treatment, diagnosis, clinical relevance, systematic reviews, clinical trials, observational studies, preappraised …

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The Plausible Role Of Deep Cervical Fascia And Its Continuum In Chronic Craniofacial And Cervicobrachial Pain: A Case Report, Prabu Raja G, Shifra Fernandes, Antony Marie Cruz, Anupama Prabhu Jul 2020

The Plausible Role Of Deep Cervical Fascia And Its Continuum In Chronic Craniofacial And Cervicobrachial Pain: A Case Report, Prabu Raja G, Shifra Fernandes, Antony Marie Cruz, Anupama Prabhu

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Background: The painful conditions of the Upper quarter region (UQR) such as chronic Craniofacial Pain (CFP) and Cervicobrachial Pain (CBP) usually occur with a plethora of symptoms. Although biological and psychosocial factors are attributed to such conditions, the involvement of the Deep Cervical Fascia (DCF) is ambiguous and needs further exploration. Objective: We reported a case of CFP and CBP with an intent to showcase the possible involvement of impaired DCF in such presentations and to explore the short-term effect of Fascia directed approach (Fascial Manipulation). Methods: This is a report of a 25-year-old female college student with chronic head, …

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Pediatric Dosage Forms-Challenges And Recent Developments: A Critical Review, Amol Dattatreya Galande, Naveen Ahuja Khurana, Srinivas Mutalik Jul 2020

Pediatric Dosage Forms-Challenges And Recent Developments: A Critical Review, Amol Dattatreya Galande, Naveen Ahuja Khurana, Srinivas Mutalik

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Pediatric population is a diverse group comprising of different subgroups. The use of unlicensed and off-label medicines for treating children is widespread due to the non-availability of suitable dosage forms for this age group. Although the physiological differences related to the diverse age group remain an important consideration, various other challenges such as insufficient background information on drug molecule, excipient safety, taste-masking issues, technology requirements, low profitability, limitations in conduct of clinical trials, and lack of regulatory clarity are also important factors adversely affecting pediatric dosage form development. These factors are discussed in this review. Liquids are the most preferred …

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'Template-Free' Hierarchical Mos2foam As A Sustainable 'Green' Scavenger Of Heavy Metals And Bacteria In Point Of Use Water Purification, Paresh Kumar Samantaray, Sushma Indrakumar, Kaushik Chatterjee, Vipul Agarwal Jul 2020

'Template-Free' Hierarchical Mos2foam As A Sustainable 'Green' Scavenger Of Heavy Metals And Bacteria In Point Of Use Water Purification, Paresh Kumar Samantaray, Sushma Indrakumar, Kaushik Chatterjee, Vipul Agarwal

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Molybdenum disulfide (MoS2), with its unique optical and electrical properties, has been explored for a variety of applications in the recent past. Still, its capabilities in point-of-use heavy metal ion removal remain to be explored. Herein, for the first time using a facile approach, we fabricated three-dimensional (3D) MoS2 foam from exfoliated single to few-layered MoS2 sheets for the selective exclusion of heavy metals and stringent bactericidal response. This foam was able to exclude 99.9% of Pb(ii) and 98.7% of As(iii) instantaneously and reduced more than 98% of bacteria E. coli. Moreover, the foam exhibits selective toxicity towards bacterial cells …

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Quantitative Proteomics Of Urinary Bladder Cancer Cell Lines Identify Uap1 As A Potential Therapeutic Target, Vinuth N. Puttamallesh, Barnali Deb, Kirti Gondkar, Ankit Jain Jul 2020

Quantitative Proteomics Of Urinary Bladder Cancer Cell Lines Identify Uap1 As A Potential Therapeutic Target, Vinuth N. Puttamallesh, Barnali Deb, Kirti Gondkar, Ankit Jain

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Bladder carcinoma (BC) incidence and mortality rates are increasing worldwide. The development of novel therapeutic strategies is required to improve clinical management of this cancer. Aberrant protein expression may lead to cancer initiation and progression. Therefore, the identification of these potential protein targets and limiting their expression levels would provide alternative treatment options. In this study, we utilized a liquid-chromatography tandem mass spectrometry-based global proteomics approach to identify differentially expressed proteins in bladder cancer cell lines. A total of 3913 proteins were identified in this study, of which 479 proteins were overexpressed and 141 proteins were downregulated in 4 out …

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Alpha Glucosidase Inhibition Activity Of Phenolic Fraction From Simarouba Glauca: An In-Vitro, In-Silico And Kinetic Study, Kirana P. Mugaranja, Ananda Kulal Jul 2020

Alpha Glucosidase Inhibition Activity Of Phenolic Fraction From Simarouba Glauca: An In-Vitro, In-Silico And Kinetic Study, Kirana P. Mugaranja, Ananda Kulal

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Food Science; Food Chemistry; Agriculture; Alpha Glucosidas; Enzyme Kinetics; Anti-diabetic; Molecular Docking; Medicinal Plant; Hypoglycaemic.

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3-Vertex Friendly Index Set Of Graphs, K. P. Girija, C. Devadas Nayak, Sabitha D’Souza, Pradeep G. Bhat Jul 2020

3-Vertex Friendly Index Set Of Graphs, K. P. Girija, C. Devadas Nayak, Sabitha D’Souza, Pradeep G. Bhat

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Graph labeling is an assignment of integers to the vertices or the edges, or both, subject to certain conditions. In literature we find several labelings such as graceful, harmonious, binary, friendly, cordial, ternary and many more. A friendly labeling is a binary mapping such that |vf (1) − vf (0)|≤ 1 where vf (1) and vf (0) represents number of vertices labeled by 1 and 0 respectively. For each edge uv assign the label |f(u) − f(v)|, then the function f is cordial labeling of G if |vf (1) − vf (0)|≤ 1 and |ef∗ (1) − ef∗ (0)|≤ 1, …

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Installing Oncofertility Programs For Common Cancers In Limited Resource Settings (Repro-Can-Open Study): An Extrapolation During The Global Crisis Of Coronavirus (Covid-19) Pandemic, M. Salama, L. Ataman-Millhouse, M. Braham, K. Berjeb Jul 2020

Installing Oncofertility Programs For Common Cancers In Limited Resource Settings (Repro-Can-Open Study): An Extrapolation During The Global Crisis Of Coronavirus (Covid-19) Pandemic, M. Salama, L. Ataman-Millhouse, M. Braham, K. Berjeb

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Purpose: The state of limited resource settings that Coronavirus (COVID-19) pandemic has created globally should be taken seriously into account especially in healthcare sector. In oncofertility, patients should receive their fertility preservation treatments urgently even in limited resource settings before initiation of anticancer therapy. Therefore, it is very crucial to learn more about oncofertility practice in limited resource settings such as in developing countries that suffer often from shortage of healthcare services provided to young patients with cancer. Methods: As an extrapolation during the global crisis of COVID-19 pandemic, we surveyed oncofertility centers from 14 developing countries (Egypt, Tunisia, Brazil, …

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Fracture Resistance Of Teeth Obturated With Two Different Types Of Mineral Trioxide Aggregate Cements, Nidambur Vasudev Ballal, Sheetal Rao, Junsang Yoo, Kishore Ginjupalli Jul 2020

Fracture Resistance Of Teeth Obturated With Two Different Types Of Mineral Trioxide Aggregate Cements, Nidambur Vasudev Ballal, Sheetal Rao, Junsang Yoo, Kishore Ginjupalli

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Objective: Endodontically obturated teeth have lower fracture resistance depending on the obturating material and technique. The purpose of this study was therefore to evaluate the influence of ProRoot MTA (Dentsply Sirona, Tulsa Division) and OrthoMTA III (BioMTA, Daejeon, Korea) as an obturating material on the fracture resistance of endodontically treated teeth. Material and Methods: Thirty extracted human maxillary central incisors were decoronated and instrumented using Protaper instruments (size F5). Irrigation was performed with 2.5% sodium hypochlorite between each instrument change followed by 7% maleic acid for one minute. Finally, canals were flushed with 5 ml of PBS solution for one …

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Current Concepts In The Management Radial Longitudinal Deficiency, Anil K. Bhat, A. M. Acharya Jul 2020

Current Concepts In The Management Radial Longitudinal Deficiency, Anil K. Bhat, A. M. Acharya

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Radial longitudinal deficiency represents a spectrum of musculoskeletal hypoplasia and dysplasia affecting the upper limb involving mainly the radial aspect of the forearm, wrist, and hand and not infrequently the proximal arm. 2/3rd of the patients with this condition suffer from an associated medical or musculoskeletal disorder and 1/3rd of them show features of a well-known syndrome with systemic manifestations. Hence it is mandatory to do a detailed clinical, radiological and laboratory evaluation which should also include genetic counselling and assessment. Its management has evolved greatly since the beginning of last century. The vast variations developed for the treatment only …

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The Effect Of High Volume Power Training On Repeated High-Intensity Performance And The Assessment Of Repeat Power Ability: A Systematic Review, Alex O. Natera, Marco Cardinale, Justin W.L. Keogh Jul 2020

The Effect Of High Volume Power Training On Repeated High-Intensity Performance And The Assessment Of Repeat Power Ability: A Systematic Review, Alex O. Natera, Marco Cardinale, Justin W.L. Keogh

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Background: High volume power training (HVPT) involves high volumes of high-velocity resistance training, with the aim to improve repeated high-intensity efforts (RHIEs). Repeat power ability (RPA) is the ability to repeatedly produce maximal or near maximal efforts. Assessments of RPA using external loading may determine the ability to perform repeat RHIEs typical of many sports and, therefore, provide useful information on the effectiveness of training. Objectives: (1) Identify the different HVPT protocols; (2) examine the acute responses and chronic adaptations to different HVPT protocols; (3) identify different lower body RPA assessment protocols and highlight similarities, differences and potential limitations between …

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Anticancer Properties Of Recipes Derived From Nigeria And African Medicinal Plants On Breast Cancer Cells In Vitro, Mutiu A. Alabi, Annamalai Muthusamy, Shama P. Kabekkodu, Olugbenga O. Adebawo Jul 2020

Anticancer Properties Of Recipes Derived From Nigeria And African Medicinal Plants On Breast Cancer Cells In Vitro, Mutiu A. Alabi, Annamalai Muthusamy, Shama P. Kabekkodu, Olugbenga O. Adebawo

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The study was carried out to examine the effects of two recipes prepared from Nigerian and African medicinal plants on the cell cytotoxicity, cell cycle distribution and apoptosis on breast cancer (MCF-7 and MDA-MB-231) cells and normal human fibroblasts. In vitro cytotoxicity and anti-proliferative effect was evaluated by 3-[4, 5-dimethylthizol-2-yl]-2, 5-diphenyltetrazolium bromide (MTT) assay while cell cycle and apoptosis were evaluated by flow cytometry using propidium iodide (PI) staining. The reactive oxygen species analysis by DCFDA staining and flow cytometry analysis while alterations in Mitochondrial Membrane Potential (MMP, ∆Ψm) were determined by staining the cells with Rhodamine 123 then FACS …

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Recurrent 1q21.1 Deletion Syndrome: Report On Variable Expression, Nonpenetrance And Review Of Literature, Priyanka Upadhyai, Eram Fatima Amiri, Vishal Singh Guleria, Stephanie L. Bielas Jul 2020

Recurrent 1q21.1 Deletion Syndrome: Report On Variable Expression, Nonpenetrance And Review Of Literature, Priyanka Upadhyai, Eram Fatima Amiri, Vishal Singh Guleria, Stephanie L. Bielas

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The clinical phenotype of 1q21.1 microdeletion syndrome is highly heterogeneous. It is characterized by dysmorphic facial features, microcephaly, and developmental delay. Several congenital defects, including cardiac, ocular, skeletal anomalies, and psychiatric or behavioural abnormalities, have also been described. Here, we report on two siblings with substantial intrafamilial phenotypic variability carrying a heterozygous deletion of the 1q21.1 region spanning a known critical genomic area (∼1.35 Mb). The microdeletion was inherited from the unaffected father. Patients described here show a spectrum of clinical features, a portion of which overlap with those previously reported in patients with 1q21.1 microdeletions. In addition, we review …

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Adding Insult To Injury: Kidney Replacement Therapy During Covid-19 In India, Raja Ramachandran, Vivekanand Jha Jul 2020

Adding Insult To Injury: Kidney Replacement Therapy During Covid-19 In India, Raja Ramachandran, Vivekanand Jha

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No abstract provided.

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