Digital Commons Network^™

Exploring The Barriers To Cervical Cancer Screening Through The Lens Of Implementers And Beneficiaries Of The National Screening Program: A Multi-Contextual Study, Jyoshma Preema Dsouza, Stephan Van Den Broucke, Sanjay Pattanshetty, William Dhoore

Open Access archive

Background: Cervical cancer is a major reason for morbidity and mortality in Low and Middle income countries. The National Programme for Prevention and Control of Cancers, Diabetes, Cardiovascular Diseases and Stroke (NPCDCS) sets out broad national guideline to implement Cervical cancer screening. However, an implementation strategy for cervical cancer screening is not in place for districts. Although opportunistic screening takes place, implementation is hindered by psychological and physical barriers for women, as well as insufficient capacity on the part of implementers. This qualitative study aims to identify the specific barriers that prevent the uptake of cervical cancer screening. Methods: Women …

Organophosphate Hydrolase Interacts With Ferric-Enterobactin And Promotes Iron Uptake In Association With Tonb-Dependent Transport System, Hari Parapatla, Ramurthy Gudla, Guruprasad Varma Konduru, Elsin Raju Devadasu

Open Access archive

Our previous studies have shown the existence of organophosphate hydrolase (OPH) as a part of the inner membrane associated Ton complex (ExbB/ExbD and TonB) of Sphingobium fuliginis. We now show its involvement in iron uptake by establishing direct interactions with ferric-enterobactin. The interactions between OPH and ferric-enterobactin were not affected even when the active site architecture is altered by substituting active site aspartate with either alanine or asparagine. Protein docking studies further substantiated these findings and predicted the existence of ferric-enterobactin binding site that is different from the catalytic site of OPH. A lysine residue (82K) found at the predicted …

Relative Quantification Of Bcl2 Mrna For Diagnostic Usage Needs Stable Uncontrolled Genes As Reference, Nehanjali Dwivedi, Sreejeta Mondal, P. K. Smitha, T. Sowmya

Open Access archive

Dysregulation of BCL2 is a pathophysiology observed in haematological malignancies. For implementation of available treatment-options it is preferred to know the relative quantification of BCL2 mRNA with appropriate reference genes. For the choice of reference genes-(i) Reference Genes were selected by assessing variation of >60,000 genes from 4 RNA-seq datasets of haematological malignancies followed by filtering based on their GO biological process annotations and proximity of their chromosomal locations to known disease translocations. Selected genes were experimentally validated across various haematological malignancy samples followed by stability comparison using geNorm, NormFinder, BestKeeper and RefFinder. (ii) 43 commonly used Reference Genes were …

Diagnostic Performance Of C-Reactive Protein Level And Its Role As A Potential Biomarker Of Severe Dengue In Adults, Raghavendra Rao, Snehal Nayak, Akhilesh K. Pandey, Shobha U. Kamath

Open Access archive

Objective: To determine the relationship between C-reactive protein (CRP) level and the severity of dengue and the potential use of CRP in predicting acute dengue infection. Methods: A prospective observational study was performed on dengue patients admitted to a tertiary care hospital in southern India. All patients of age above 18 years, diagnosed with dengue were included in the study. The detailed laboratory parameters pertaining to dengue were recorded. CRP levels were estimated and compared between groups i.e. severe and non-severe dengue. CRP cut-off value was detected using the receiver-operator curve. Results: Totally 98 patients with a mean age of …

Monitoring Universal Health Coverage Reforms In Primary Health Care Facilities: Creating A Framework, Selecting And Fieldtesting Indicators In Kerala, India, Devaki Nambiar, D. Hari Sankar, Jyotsna Negi, Arun Nair

Open Access archive

In line with the Sustainable Development Goals (SDGs) and the target for achieving Universal Health Coverage (UHC), state level initiatives to promote health with "no-one left behind"are underway in India. In Kerala, reforms under the flagship Aardram mission include upgradation of Primary Health Centres (PHCs) to Family Health Centres (FHCs, similar to the national model of health and wellness centres (HWCs)), with the proactive provision of a package of primary care services for the population in an administrative area. We report on a component of Aardram's monitoring and evaluation framework for primary health care, where tracer input, output, and outcome …

Histone Demethylase Kdm5b As A Therapeutic Target For Cancer Therapy, Anmi Jose, Gautham G. Shenoy, Gabriel Sunil Rodrigues, Naveena A.N. Kumar

Open Access archive

Lysine-specific demethylase 5B (KDM5B/PLU1/JARID1B) is found to be overexpressed in numerous malignancies, including breast, lung, skin, liver, and prostate cancer. Identification of molecules targeting the KDM5B enzyme could be a potential lead in cancer research. Although many KDM5B inhibitors with promising outcomes have been developed so far, its further application in clinical practice is limited due to toxicity and lack of target specificity. Here, we summarize the significance of targeting KDM5B in anticancer therapy and report the molecular docking studies of some known anti-viral agents, decitabine, entecavir, abacavir, penciclovir, and 3-deazaneplanocin A in the catalytic domain JmjC of KDM5B. These …

Women's Football: An Examination Of Factors That Influence Movement Patterns, Jesse Griffin, Brianna Larsen, Sean Horan, Justin Keogh

Open Access archive

The popularity and professionalism of women's football has increased in conjunction with participation rates over the last 10 years, with projected female participation rates to double worldwide by 2026. Scientific interest has also increased, in part due to Fédération Internationale de Football Association now allowing global positioning system (GPS) units to be worn during all competitive matches, resulting in investigations into the match demands of women's football. Therefore, the purpose of the present review is to provide a summary of the literature specific to the movement patterns of women's football matches. Contemporary scientific investigation using GPS match data has led …

Molecular Assessment Of Epiretinal Membrane: Activated Microglia, Oxidative Stress And Inflammation, Sushma Vishwakarma, Rishikesh Kumar Gupta, Saumya Jakati, Mudit Tyagi

Open Access archive

Fibrocellular membrane or epiretinal membrane (ERM) forms on the surface of the inner limiting membrane (ILM) in the inner retina and alters the structure and function of the retina. ERM formation is frequently observed in ocular inflammatory conditions, such as proliferative diabetic retinopathy (PDR) and retinal detachment (RD). Although peeling of the ERM is used as a surgical intervention, it can inadvertently distort the retina. Our goal is to design alternative strategies to tackle ERMs. As a first step, we sought to determine the composition of the ERMs by identifying the constituent cell-types and gene expression signature in patient samples. …

Mapping Geographical Inequalities In Oral Rehydration Therapy Coverage In Low-Income And Middle-Income Countries, 2000-17, Kirsten E. Wiens, Paulina A. Lindstedt, Brigette F. Blacker, Kimberly B. Johnson

Open Access archive

Background: Oral rehydration solution (ORS) is a form of oral rehydration therapy (ORT) for diarrhoea that has the potential to drastically reduce child mortality; yet, according to UNICEF estimates, less than half of children younger than 5 years with diarrhoea in low-income and middle-income countries (LMICs) received ORS in 2016. A variety of recommended home fluids (RHF) exist as alternative forms of ORT; however, it is unclear whether RHF prevent child mortality. Previous studies have shown considerable variation between countries in ORS and RHF use, but subnational variation is unknown. This study aims to produce high-resolution geospatial estimates of relative …

First Report Of Pharmaceuticals And Personal Care Products In Two Tropical Rivers Of Southwestern India, Derrick Ian Joshua, Yerabham Praveenkumarreddy, Valiparambil Prabhakaranunni Prabhasankar, Andrea Petula D’Souza

Open Access archive

The occurrence of selected pharmaceuticals (trimethoprim, sulfamethoxazole, chloramphenicol, bezafibrate, ceftriaxone, and naproxen) in two west-flowing tropical rivers (Swarna and Nethravati) of southwestern India is reported for the first time. Water samples were collected during the monsoon and post-monsoon seasons from river water end members and further downstream up to their confluence with the adjacent Arabian Sea. Samples were analyzed using HPLC–MS/MS. Results revealed that there were no significant seasonal variations in concentrations of target analytes in both the rivers. Of the total number of samples analyzed (n = 24), trimethoprim was detected in 100% of the samples, whereas sulfamethoxazole (SMX), …

Discarded Covid 19 Gear: A Looming Threat, Sameep S. Shetty, Barbara Wollenberg, Yash Merchant, Nikita Shabadi

Open Access archive

No abstract provided.

Aggregated Covid-19 Suicide Incidences In India: Fear Of Covid-19 Infection Is The Prominent Causative Factor, Deena Dimple Dsouza, Shalini Quadros, Zainab Juzer Hyderabadwala, Mohammed A. Mamun

Open Access archive

Many Indian COVID-19 suicide cases are turning the press-media attention and flooding in the social media platforms although, no particular studies assessed the COVID-19 suicide causative factors to a large extent. Therefore, the present study presents 69 COVID-19 suicide cases (aged 19 to 65 years; 63 cases were males). The suicide causalities are included as follows – fear of COVID-19 infection (n=21), followed by financial crisis (n=19), loneliness, social boycott and pressure to be quarantine, COVID-19 positive, COVID-19 work-related stress, unable to come back home due to lockdown, unavailability of alcohol etc. Considering the extreme psychological impacts related to COVID-19, …

Association Of Health Literacy And Cognition Levels With Severity Of Adverse Drug Reactions In Cancer Patients: A South Asian Experience, Vishal Gupta, Gangachannaiah Shivaprakash, Dipanjan Bhattacherjee, Karthik Udupa

Open Access archive

Background The occurrence of adverse drug reactions with chemotherapy among cancer patients is a well-documented phenomenon. However, the understanding of contributoring factors and their influence on the severity of adverse drug reactions is incomplete without the psychosocial factors affecting them. Objective The present study was done to understand if factors like Health literacy and cognition levels have an association with the severity of adverse drug reactions of cancer chemotherapy. Setting This study was done in the Department of Medical Oncology in a tertiary care hospital in India. Method Two hundred and twenty-four patients meeting the study inclusion and exclusion criteria …

Structural Proteins In Severe Acute Respiratory Syndrome Coronavirus-2, Sairaj Satarker, Madhavan Nampoothiri

Open Access archive

What began with a sign of pneumonia-related respiratory disorders in China has now become a pandemic named by WHO as Covid-19 known to be caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). The SARS-CoV-2 are newly emerged β coronaviruses belonging to the Coronaviridae family. SARS-CoV-2 has a positive viral RNA genome expressing open reading frames that code for structural and non-structural proteins. The structural proteins include spike (S), nucleocapsid (N), membrane (M), and envelope (E) proteins. The S1 subunit of S protein facilitates ACE2 mediated virus attachment while S2 subunit promotes membrane fusion. The presence of glutamine, asparagine, leucine, phenylalanine …

A Quad Band Planar Slotted Microstrip Patch Antenna For Wireless Applications, Reshma Roy, Apurva Singh, Om Prakash Kumar, Tanweer Ali

Open Access archive

This research paper presents two different types of multiband patch antenna. The first design is a dual-band antenna and the second design is a quad-band antenna. Both the antennas have a compact size of, and is designed on FR4 substrate with loss tangent (=0.02, height (h)=1.6 mm, with dielectric constant of 4.4. The dual-band antenna operates at frequencies 3.9 and 5.71 GHz. These dual band operations are accomplished by utilizing L-shaped slot in the ground part and T-shaped slot in the radiating part of the patch antenna. The gain corresponding to the two frequency bands are 1.27 and 1.35 dB, …

Vicissitudes In Oncological Care During Covid19, Sameep S. Shetty, Barbara Wollenberg, Nikita Shabadi, Akshay Shivappa Kudpaje

Open Access archive

No abstract provided.

Cpg-Snp Site Methylation Regulates Allele-Specific Expression Of Mthfd1 Gene In Type 2 Diabetes, Manik Vohra, Prabha Adhikari, Sydney C.D’ Souza, Shivashankar K. Nagri

Open Access archive

The interaction of genetic and epigenetic mechanisms is one of the underlying causes of phenotypic variability in complex diseases such as type 2 diabetes (T2D). To explore the influence of genetic and epigenetic changes in T2D, we examined the effect of methylation of CpG-SNP sites on allele-specific expression (ASE) in one-carbon metabolism pathway genes in T2D. Case-control study was conducted on 860 individuals (430 T2D and 430 controls). CpG-SNPs shortlisted through in silico analysis were genotyped using tetra ARMS PCR and validated using Sanger DNA sequencing. Global DNA methylation was carried out using RP-HPLC. Promoter DNA methylation and CpG site-specific …

Validation Of An Indian (Kannada) Translation Of The Family Impact Scale Questionnaire And The Impact Of Malocclusion On The Families Of Adolescent School Children, Kalaiselvi Vinayagamoorthy, Kalyana Chakravarthy Pentapati, Arun Urala, Shashidhar Acharya

Open Access archive

Objectives: The objectives of this study were to validate an Indian translation of the Family Impact Scale (FIS) questionnaire and assess the impact of malocclusion on the families of adolescent school children between 12 and 15 years old across socio-economic strata (SES). Materials and methods: The sample consisted of 768 school children aged between 12 and 15 years from randomly selected schools in Udupi district. The FIS and informed consent forms were sent through the children to be completed by their parents. Information was collected on socio-demographic details, past dental visit in the last year, type of school and SES. …

Studying The Oxygen Effect In Proton Therapy Via Gpu-Based Microscopic Monte Carlo Simulation, Marcos Joseph Guillen

Physics Theses - Archive

Dissolved oxygen molecules are known to play an important role in radiotherapy. For example, tumor cells can be more radio-resistance under hypoxia than normoxia. There has been multiple hypothesis proposed to explain these phenomena, including the oxygen mediated chemical track evolution. In principle, we can perform microscopic Monte Carlo (MC) simulation to quantitively test this hypothesis. Yet, to avoid the extreme high computational resource consuming, in the current CPU-based MC tools, oxygen is either ignored or taken as a continuous radical-scavenging background. Recently, our research group developed an open-source, GPU-based MC simulation tool, gMicroMC, in which, the oxygen mediated chemical …

Pathogens, Endosymbionts, And Blood-Meal Sources Of Host-Seeking Ticks In The Fast-Changing Maasai Mara Wildlife Ecosystem, Joseph Wang’Ang’A Oundo, Jandouwe Villinger, Maamun Jeneby, George Ong’Amo, Moses Yongo Otiende, Edward Edmond Makhulu, Ali Abdulahi Musa, Daniel Obado Ouso, Lillian Wambua

All Peer-Reviewed Publications

The role of questing ticks in the epidemiology of tick-borne diseases in Kenya’s Maasai Mara National Reserve (MMNR), an ecosystem with intensified human-wildlife-livestock interactions, remains poorly understood. We surveyed the diversity of questing ticks, their blood-meal hosts, and tick-borne pathogens to understand potential effects on human and livestock health. By flagging and hand-picking from vegetation in 25 localities, we collected 1,465 host-seeking ticks, mostly Rhipicephalus and Amblyomma species identified by morphology and molecular analysis. We used PCR with high-resolution melting (HRM) analysis and sequencing to identify Anaplasma, Babesia, Coxiella, Ehrlichia, Rickettsia, and Theileria pathogens and blood-meal remnants in 231 tick …

Women's Empowerment Boosts The Gains In Dietary Diversity From Agricultural Technology Adoption In Rural Kenya, Menale Kassie, Monica Fisher, Geoffrey Muricho, Gracious Diiro

All Peer-Reviewed Publications

Using new survey data from rural Kenya, this paper assesses the moderating effect of women's empowerment on the relationship between agricultural technology adoption and women's dietary diversity. We use a multiple treatment endogenous switching regression framework to control for potential endogeneity of women's empowerment and technology adoption. We find that women's empowerment has a positive and significant effect on the women's dietary diversity score regardless of technology adoption status. We further show that women's empowerment enhances the positive effects of technology adoption on women's dietary diversity. Although technology adoption has a positive impact on women's dietary diversity regardless of empowerment …

Tropical Forage Technologies Can Deliver Multiple Benefits In Sub-Saharan Africa. A Meta-Analysis, Birthe K. Paul, Jessica Koge, Brigitte L. Maass, An Notenbaert, Michael Peters, Jeroen C.J. Groot, Pablo Tittonell

All Peer-Reviewed Publications

Scarcity of quantity and quality feed has been a key constraint to productivity of smallholder crop-livestock systems. Tropical forages include a variety of annual and perennial grasses, herbaceous and dual-purpose legumes, and multipurpose trees and shrubs. They have been promoted in Sub-Saharan Africa (SSA) for increasing livestock productivity and household income through higher quantity and quality of herbage, while contributing to soil improvement and higher food crop yields. For the first time, we quantitatively reviewed 72 experimental studies from across SSA to take stock of geographical distribution and forage technology focus of past research; quantify magnitudes of multidimensional impacts of …

Data For "Consistent Differences In A Virtual World Model Of Ape Societies", Bart J. Wilson, Sarah F. Brosnan, Elizabeth V. Lonsdorf, Crickette M. Sanz

Business and Economics Faculty Data Sets

The zip file contains the data for the paper entitled "Consistent Differences in a Virtual World Model of Ape Societies" which appears in Scientific Reports.

Sexually Transmitted Infection Prevalence Among Women At Risk For Hiv Exposure Initiating Safer Conception Care In Rural, Southwestern Uganda, Pooja Chitneni, Mwebesa Bosco Bwana, Moran Owembabazi, Kasey O'Neil, Paul Kato Kalyebara, Winnie Muyindike, Nicholas Musinguzi, David R. Bangsberg, Jeanne M. Marrazzo, Jessica E. Haberer, Angela Kaida, Lynn T. Matthews

OHSU-PSU School of Public Health Faculty Publications and Presentations

Background Knowledge of sexually transmitted infection (STI) prevalence and risk factors is important to the development of tenofovir-based preexposure prophylaxis (PrEP) and safer conception programming. We introduced STI screening among women at risk for HIV exposure who were participating in a safer conception study in southwestern Uganda. Methods We enrolled 131 HIV-uninfected women, planning for pregnancy with a partner living with HIV or of unknown HIV serostatus (2018-2019). Women were offered comprehensive safer conception counseling, including PrEP. Participants completed interviewer-administered questionnaires detailing sociodemographics and sexual history. We integrated laboratory screening for chlamydia, gonorrhea, trichomoniasis, and syphilis as a substudy to …

2020-07-31_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

Seal, Social Experiences In Assisted Living: Social Network Analysis Data, Rebecca Mauldin

Social Work Datasets

This dataset is from a longitudinal social network analysis research project that collected survey data on three separate occasions over a 6-month period from residents in a single assisted living facility. It includes psychosocial survey data and social network survey data on acquaintance, companionship, social support, and negative interaction ties among residents of the assisted living facility. === We recommend reading the README.txt and Data Overview - SEAL.pdf files for an orientation to the dataset. ===

2020-07-31_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Seal, Social Experiences In Assisted Living: Social Network Analysis Data, Rebecca Mauldin

Social Networks for Social Good Collection-Archive

This dataset is from a longitudinal social network analysis research project that collected survey data on three separate occasions over a 6-month period from residents in a single assisted living facility. It includes psychosocial survey data and social network survey data on acquaintance, companionship, social support, and negative interaction ties among residents of the assisted living facility. === We recommend reading the README.txt and Data Overview - SEAL.pdf files for an orientation to the dataset. ===

2020-07-30_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

2020-07-30_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …