Digital Commons Network^™

Go Go Ro Bo, Jordan Goodwin

Game Design

Go Go Ro Bo is a proof of concept for a runner-like game. In the game, players move Ro Bo up and down past various obstacles throughout the mall and collect gummy rats.

Kentucky Geological Survey Landslide Inventory [2024], Matthew M. Crawford, Evelyn M. Bibbins, Hudson J. Koch

Research Data--KGS

The KGS landslide inventory provides the locations of known landslides and areas susceptible to debris flows. Various types of landslides are represented including slides, flows, rockfalls, and creep. The data are available as ArcGIS geodatabase feature classes. Landslide locations and associated attributes are compiled from Kentucky Geological Survey research, published maps, state and local government agencies, the public, and media reports. A confidence ranking system assigns a value to each feature. A description of the feature classes is here: https://kgs.uky.edu/kgsmap/helpfiles/landslide_help.shtm

The inventory viewed in a GIS with geology, soils, slope or other terrain-based data can serve as a basis for …

Efficient Internalization Of Nano Architectured 177lu-Hyaluronic Acid@ Zirconium-Based Metal-Organic Framework For The Treatment Of Neuroblastoma: Unravelling Toxicity, Stability, Radiolabelling And Bio-Distribution, Sanjay Kulkarni, Abhijeet Pandey, Soji Soman, Shivanand H. Nannuri

Open Access archive

Zirconium-based metal-organic frameworks (UiO-66) have gained considerable attention owing to their versatile application. In the present research, UiO-66 was synthesized via a defect engineering approach, and its toxicity profile was explored. The synthesized nanomaterial was extensively characterized via spectroscopic methods such as FTIR and Raman spectroscopy, which confirmed the formation of the framework. X-ray diffraction (XRD) and transmission electron microscopy (TEM) were used to determine the crystallinity, shape and size of the nanoformulations. Thermal gravimetric analysis, ¹H NMR spectroscopy and Brunauer–Emmett–Teller (BET) surface area analysis were used to identify the differences between pristine and defective UiO-66. Furthermore, the synthesized …

Deep-Millet: A Deep Learning Model For Pearl Millet Disease Identification To Envisage Precision Agriculture, I. Johnson, X. Anitha Mary, A. Peniel Winifred Raj, J. Chalmers

Open Access archive

Plants are integral to human sustenance, serving as fundamental sources of sustenance, materials, and energy, crucial for economic prosperity. However, their productivity and yield are increasingly threatened by pests and diseases, exacerbated by shifting climatic conditions. Pearl millet, a vital crop in Africa and Asia, is particularly susceptible to a range of diseases including downy mildew, rust, ergot, smut, and blast, posing significant risks to crop yield and quality. Timely and accurate disease identification is paramount for effective management strategies. Traditional methods of disease detection relying on visual identification are laborious, costly, and often require specialized expertise, presenting formidable challenges …

Exploring The Contribution Of Cancer Palliative Care Development Toward Alleviating The Human Crisis Of Suffering In Low- And Middle-Income Countries: A Framework Synthesis Protocol, Shrikant Atreya, Arathi Rao, Vijay Shree Dhyani, Mebin Mathew

Open Access archive

Objectives. Inadequate access to cancer care, high mortality, and out-of-pocket expenditure contribute to health-related suffering in low- and middle-income countries, making palliative care a relevant option. How palliative care development has alleviated suffering is not systematically studied, necessitating this review’s conduct. The objective of this systematic review with a framework synthesis approach is to identify and map the dimensions and indicators of cancer palliative care development and the components of integration between cancer and palliative care in LMICs. Methods. Uni- and multi-disciplinary databases like Cochrane, MEDLINE (PubMed), EMBASE, CINAHL Complete, and PsycINFO will be systematically searched for eligible studies exploring …

Amyloid Accelerator Polyphosphate Fits As The Mystery Density In Α-Synuclein Fibrils, Philipp Huettemann, Pavithra Mahadevan, Justine Lempart, Eric Tse

Open Access archive

Aberrant aggregation of α-Synuclein is the pathological hallmark of a set of neurodegenerative diseases termed synucleinopathies. Recent advances in cryo-electron microscopy have led to the structural determination of the first synucleinopathy-derived α-Synuclein fibrils, which contain a non-proteinaceous, “mystery density” at the core of the protofilaments, hypothesized to be highly negatively charged. Guided by previous studies that demonstrated that polyphosphate (polyP), a universally conserved polyanion, significantly accelerates α-Synuclein fibril formation, we conducted blind docking and molecular dynamics simulation experiments to model the polyP binding site in α-Synuclein fibrils. Here, we demonstrate that our models uniformly place polyP into the lysine-rich pocket, …

Role Of Absolute Versus Relative Voice Rest In Post-Operative Management Of Benign Vocal Fold Lesions, Mihika Sinha, Suresh Pillai, Shama Shetty, Usha Devadas

Open Access archive

Objective Most otolaryngologists advocate absolute voice rest after laryngeal surgery, which proves difficult for patients, so we decided to evaluate the role of absolute voice rest versus relative voice rest in the post-operative management of benign lesions. Methods Forty patients were recruited and divided in two groups: absolute voice rest and relative voice rest. Pre- and post-operative voice analysis (fundamental frequency, jitter, shimmer, voice handicap index, voice-related quality-of-life scale scores and compliance) were noted at one week and one month. Results Voice analysis parameters including jitter (p = 0.035), shimmer (p = 0.020), voice handicap index (p < 0.001) and compliance (p < 0.001) were better in the relative voice-rest group. Frequency, number of voice breaks and voice-related quality of life showed no statistically significant results. Conclusion There was no significant benefit of absolute voice rest on post-operative outcomes as determined by acoustic variables. Compliance and quality-of-life scores were low in the strict voice-rest group. Therefore, we should reconsider post-surgical voice-rest protocol.

Suitability Of Using Mussel Shells As Partial Replacement Of Aggregates In Self-Compacting Concrete, Gopal Bharamappa Bekkeri, Kiran K. Shetty, Gopinatha Nayak, Sinan Asenar Saheb

Open Access archive

The handling of mussel shell wastes in coastal regions presents an issue that may be addressed by using mussel shells as a construction material. Shells from waste mussels replace aggregate in concrete, whole or in part. The shells of the mussels are well suited to be incorporated as aggregate into a concrete mix since they are primarily composed of limestone, a substance similar to the other ingredients in concrete. The current study focuses on the suitability of using mussel shells to replace aggregates in self-compacting concrete (SCC). The aggregates were substituted with mussel shells in 5, 10, 15, and 20 …

Influence Of Lead On Camp-Response Element Binding Protein (Creb) And Its Implications In Neurodegenerative Disorders, Sharal Alva, Aluru Parithathvi, P. Harshitha, Herman Sunil Dsouza

Open Access archive

Lead (Pb²⁺) is one of the most common toxic metals present in the environment, and lead exposure causes serious health issues in humans. Lead is widely used because of its physio-chemical characteristics, which include softness, corrosion resistance, ductility, and low conductivity. Lead affects almost all human organs, specifically the central nervous system. Lead neurotoxicity is connected to various neural pathways, including brain-derived neurotrophic factor (BDNF) protein level alterations, cyclic adenosine 3′,5′-monophosphate (cAMP) response element binding protein (CREB) pathway changes, and N-methyl-D-aspartate receptors (NMDARs) changes. Lead primarily affects protein kinase C (PKC) through the replacement of calcium (Ca^{2+ …}

Glycemic Control And Its Relationship Between Lipid Profiles And Thyroid Profiles: Insights From A Case? Control Study From Coastal Karnataka, South India, Akhila Doddamani, A. B. Kirthinath Ballala, Yash Alok, Ratna Jay

Open Access archive

Introduction: In India, the burden of diabetes mellitus is rising swiftly, mirroring a global trend that is being observed in both developed and developing countries. Examining the correlation between indices of glycemic status & thyroid and lipid parameters at different glycemic control levels was the goal of the present study. Methods: This case control study included 50 cases (HbA1c > 6.5 %) and 150 controls (HbA1C < 6.5) who were attending an executive health check up at a tertiary level health care hospital attached to a medical college in a coastal city in Southern India. Glycemic indices, thyroid profile and lipid profile were evaluated. Correlation analyses, t-tests, and chi-square tests were carried out. Results: Cases had a mean age of 57.80±10.71 years whereas controls had a mean age of 48.47±13.89 years. The cases and controls did not have discernable differences in the lipid profile characteristics. However, T4 and HbA1C (Glycated Hemoglobin), depicted a weak positive correlation with the value of correlation coefficient r= 0.211 (p= 0.014). With respect to T4, there was a higher mean rank contrast observed among the cases than that of controls (p=0.014). Conclusion: A positive association between thyroid hormone T4 levels and glycemic status was found in this study, even if no correlation was found between glycemic control and lipid profile. This research lays emphasis on closely observing thyroid function in addition to glycemic parameters for the all-encompassing control of diabetes mellitus.

Compatibility Of Dual Rinse 1-Hydroxyethane-1,1-Diphosphonic Acid With Sodium Hypochlorite Solutions Containing Proprietary Additives, Honey Kottathil, Matthias Zehnder, Andrea Gubler, Thomas Attin

Open Access archive

Introduction: A salt of 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP) was commercialized some years ago. This so-called Dual Rinse (DR) HEDP has been tested for its combined actions and interactions with pure sodium hypochlorite (NaOCl) solutions. The aim of this study was to assess DR interactions with NaOCl solutions containing proprietary additives. Methods: Designated endodontic NaOCl solutions that come at 2 different strengths (2% and 5.25%), and without or with additives (Chloraxid and Chloraxid Extra, respectively) were tested. Some of their key chemical and physical properties were determined in the presence or absence of HEDP (9%) in the solution. In addition, soft tissue …

Performance Evaluation Of P-Type Cr2o3 Thin Films Grown By Reactive Dc Magnetron Sputtering For Schottky Diode Applications, Prathiksha, K. A. Jagadish, Dhananjaya Kekuda

Open Access archive

In this study, we present a comprehensive investigation into the impact of combined oxygen and argon flow rates on the physical properties of Cr2O3 thin films produced via reactive DC magnetron sputtering. Additionally, we explore the influence of oxygen flow rate on various aspects, including structural, morphological, optical, chemical, and electrical characteristics of the sputtered Cr2O3 thin films. Our analysis, based on XRD results, reveals the polycrystalline nature of the films. Surface morphology was examined through scanning electron microscopy. Optical analysis indicates a band gap ranging from 2.70 eV to 2.99 eV for the films. X-ray photoelectron spectroscopy analysis shows …

Phage Therapy: A Novel Approach Against Multidrug-Resistant Pathogens, Arushi Kapoor, Samriti Balaji Mudaliar, Vyasraj G. Bhat, Ishita Chakraborty

Open Access archive

The rapid rise of multidrug-resistant (MDR) organisms has created a critical need for alternative treatment options. Phage therapy is gaining attention as an effective way to fight bacterial infections by using lytic bacteriophages to specifically target and kill harmful bacteria. This review discusses several phage therapeutic options and emphasizes new developments in phage biology. Phage treatment has proven to be successful against MDR bacteria, as evidenced by multiple human clinical trials that indicate favorable results in treating a range of diseases caused by these pathogens. Despite these promising results, challenges such as phage resistance, regulatory hurdles, and the need for …

A Multiparameter Sensing Spectroscopic System For Remote Plastic Sorting With A Single Laser Shot: A First Information Report, U. K. Adarsh, V. K. Unnikrishnan

Open Access archive

The spectroscopic methods have been widely applied for plastic characterization and sorting to assist the recycling process. However, most of the reported works have been carried out in conventional laboratory conditions. In this study, we discuss development and application of a single-shot standoff multimodal LIBS-Raman spectroscopy system for plastic identification by modifying existing optical models for such analyses. By utilizing a unique co-axial back-collection optical geometry in standoff signal collection and a direct signal coupling scheme, the system was able to sense LIBS-Raman signals from plastics in single laser shot mode within 20 ms, with a non-gated CCD detector remotely. …

Unleashing The Power Of Polymeric Nanoparticles — Creative Triumph Against Antibiotic Resistance: A Review, Gaurisha Alias Resha Ramnath Naik, Amrita Arup Roy, Srinivas Mutalik, Namdev Dhas

Open Access archive

Antibiotic resistance (ABR) poses a universal concern owing to the widespread use of antibiotics in various sectors. Nanotechnology emerges as a promising solution to combat ABR, offering targeted drug delivery, enhanced bioavailability, reduced toxicity, and stability. This comprehensive review explores concepts of antibiotic resistance, its mechanisms, and multifaceted approaches to combat ABR. The review provides an in-depth exploration of polymeric nanoparticles as advanced drug delivery systems, focusing on strategies for targeting microbial infections and contributing to the fight against ABR. Nanoparticles revolutionize antimicrobial approaches, emphasizing passive and active targeting. The role of various molecules, including small molecules, antimicrobial peptides, proteins, …

Imidazole-Based Ionic Liquid As Sustainable Green Inhibitor For Corrosion Control Of Steel Alloys: A Review, Namitha Kedimar, Padmalatha Rao, Suma A. Rao

Open Access archive

Corrosion refers to the degradation of materials caused by exposure of materials to the corrosive environment. The toxicity of some of the synthesised chemical compounds used as inhibitors has initiated the search for eco-friendly inhibitors. Primary goal of this review is to endorse the development of greener corrosion inhibitors and the study of ionic liquids as a viable alternative to chemical inhibitors. Ionic liquids are biodegradable, less volatile, non-inflammable, and less toxic and can be used as inhibitors to protect various metals and alloys from corrosion. Ionic liquids adsorb at the interface of metal and electrolyte. Adsorption of ionic liquids …

The Spaire Approach For Hip Arthroplasty: Short-Term Functional Outcome In An Indian Scenario, Jayant Kumar, Akash Nagnath Mane, Nishant Kumar Niraj, Kumar Rahul

Open Access archive

Introduction : Hip arthroplasty, including hemiarthroplasty and total hip arthroplasty is a common surgical procedure for patients suffering from hip joint disorders with an aim of complication free early return to activities of daily living. Various minimally invasive surgical approaches have been described to achieve this aim including a relatively new SPAIRE approach. This case series shows our technique of hip arthroplasty using the SPAIRE technique with the help of conventional instruments in an Indian Scenario at a tertiary care center in Eastern India along with our short-term functional outcomes till a follow up period of 6 months. Materials and …

Enhancement In Power Factor Through Rare-Earth Samarium Doping In Cu2snse3 System, Twinkle Gurung, Rohith Jagan, Deepika Shanubhogue U, G. Poojitha

Open Access archive

Cu2SnSe3 has drawn enough attention as a potential thermoelectric material due to its unique electronic and thermal properties. We present the impact of Sm doping on the Cu2SnSe3 system’s Sn site. The polycrystalline samples of Cu2Sn1-x Smx Se3 (0 ≤ x ≤ 0.08) were prepared using the solid-state reaction technique followed by conventional sintering. The crystal structure was characterized using XRD and the results reveal that the samples have a diamond cubic structure with a space group of F4̄3m. Scanning Electron Microscopy (SEM) analysis indicates a uniform surface homogeneity within the sample. Furthermore, the introduction of Sm causes a reduction …

Development Of A Machine Learning-Based Model For The Prediction And Progression Of Diabetic Kidney Disease: A Single Centred Retrospective Study, Sandhya Nayak, Ashwini Amin, Swetha R. Reghunath, Girish Thunga

Open Access archive

Background: Diabetic kidney disease (DKD) is a diabetic microvascular complication often characterized by an unpredictable progression. Hence, early detection and recognition of patients vulnerable to progression is crucial. Objective: To develop a prediction model to identify the stages of DKD and the factors contributing to progression to each stage using machine learning. Methodology: A retrospective study was conducted in a South Indian tertiary care hospital and collected the details of patients diagnosed with DKD from January 2017 to January 2022. Bayesian optimization-based machine learning techniques such as classification and regression were employed. The model was developed with the help of …

An Empirical Study On Implementation Of Ai & Ml In Stock Market Prediction, N. Venkatarathnam, Laxmana Rao Goranta, P. C. Kiran, B. P.G. Raju

Open Access archive

The introduction of Artificial Intelligence (AI) and Machine Learning (ML) has transformed numerous fields, including agriculture, industry, economy, and medicine, with significant advancements in automation and decision-making processes. Today, AI and ML have also made notable strides in financial markets, particularly in stock and foreign exchange (Forex) forecasting, where complex algorithms are used to predict market movements and assist in decision-making. This paper examines such applications, particularly on using AI and ML techniques in the stock trading and market prediction. Specifically for this paper, the general approach to the application of AI and more concretely the ML in the trading …

A Hybrid Merec-Topsis Approach For The Improvement Of Physical Vapour Deposited Titanium Carbo-Nitride Coating, Ranjan Kumar Ghadai, Kanak Kalita, Mukul Gupta

Open Access archive

Titanium carbo-nitride (TiCN) comes under the metal nitride group which can provide a combined property of titanium carbide (TiC) and titanium nitride (TiN) coating. TiCN Coating possess an excellent mechanical and tribological, properties which leads its application in many industries particularly in the Automotive and aerospace industries. TiCN films can be very hard and strong based on the composition and synthesis process. Physical Vapor Deposition (PVD) technique is widely used for the preparation of thin film coating because of its ability to precisely control the composition and thickness of the coatings. The properties of the developed coating significantly affect by …

Candidate Ram-Pressure Stripped Galaxies In Six Low-Redshift Clusters Revealed From Ultraviolet Imaging, K. George, B. M. Poggianti, A. Omizzolo, B. Vulcani

Open Access archive

The assembly of galaxy clusters is understood to be a hierarchical process with a continuous accretion of galaxies over time, which increases the cluster size and mass. Late-type galaxies that fall into clusters can undergo ram-pressure stripping, forming extended gas tails within which star formation can happen. The number, location, and tail orientations of such galaxies provide clues about the galaxy infall process, the assembly of the cluster over time, and the consequences of infall for galaxy evolution. Here, we utilise the ∼0.5-degree diameter circular field of the Ultraviolet Imaging Telescope to image six galaxy clusters at z<0.06 that are known to contain 'jellyfish'galaxies. We searched for stripping candidates in the ultraviolet images of these clusters, which revealed 54 candidates showing signs of unilateral extra-planar emission, due to ram-pressure stripping. Seven candidates had already been identified as likely stripping based on optical B-band imaging. We identified 47 new candidates through UV imaging. Spectroscopic redshift information is available for 39 of these candidate galaxies, of which 19 are associated with six clusters. The galaxies with spectroscopic redshifts that are not part of the clusters appear to be within structures at different redshifts identified as additional peaks in the redshift distribution of galaxies, indicating that they might be ram-pressure stripped or disturbed galaxies in other structures along the line of sight. We examine the orbital history of these galaxies based on their location in the position-velocity phase-space diagram and explore a possible connection to the orientation of the tail direction among cluster member candidates. There are limitations due to different integration times and imaging different regions with respect to the cluster centre. The tails of confirmed cluster member galaxies are found to be oriented away from the cluster centre.

“It’S Not A One-Person Show” E-Learning Course In Neuropalliative Care: A Qualitative Analysis Of Participants’ Educational Gains And Self-Reported Outcomes, Sarah K. Bublitz, Mara Lugassy, Roop Gursahani, Winnie Lau

Open Access archive

Objectives. Patients with progressive neurologic illness still lack access to quality palliative care services. Barriers to the comprehensive provision of neuropalliative care include gaps in palliative care education. To address this barrier, a novel international model of neuropalliative care education e-learning program was launched in 2022. Methods. This is a qualitative study on the self-reported learning outcomes and educational gains of participants of a neuropalliative care e-learning course. Results. Thematic analysis shows changes in the participants’ perceptions of neuropalliative care and several specific educational gains. After attending the course, participants recognized neuropalliative care as a multiprofessional and interdisciplinary effort requiring …

Entwined Derelict, Alex Teeple

Harrisburg University Other Works

"Entwined Derelict" was my first delve into the Twine interactive fiction engine, and the second game that I consider "feature complete". While a significant focus was put on learning the engine as a whole, particular effort for me was put into a sidebar "journal" of sorts, that took narrative flags from the game and recorded the events in a way that allows players to read back what they have experienced in-game at their leisure. While I greatly enjoyed making the game, and I do consider it a complete experience with some unique pieces within, it is a short adventure without …

"Gregory Berns’ Journey: Uncovering The Emotional Lives Of Cows And Other Animals", Leslie Barcus, Steven Hansch

Tales of WellBeing

Explore Gregory Berns’ heartwarming journey from neuroscientist to farmer, where he uncovers the emotional intelligence of cows, drawing parallels to dogs and advocating for kinder treatment of animals in his new book.

Celebrating The Adventures Of Owney And Boji: How Two Famous Dogs Captured Hearts Across Generations, Kathleen Rowan, Andrew Rowan

Tales of WellBeing

Follow the incredible journeys of Owney, the 19th-century mail train rider, and Boji, Istanbul’s modern-day commuter dog. Learn how these remarkable dogs inspired love, loyalty, and fascination in people across the world, even from a distance.

Teaching Music To Students With Differences And Disabilities: A Label-Free Approach, Alice M. Hammel, Ryan M. Hourrigan

ABLE Books

No abstract provided.

Neuroepithelial Bodies And Terminal Bronchioles Are Niches For Distinctive Club Cells That Repair The Airways Following Acute Notch Inhibition, Sai Manoz Lingamallu, Aditya Deshpande, Neenu Joy, Kirthana Ganeshan

Open Access archive

Lower airway club cells (CCs) serve the dual roles of a secretory cell and a stem cell. Here, we probe how the CC fate is regulated. We find that, in response to acute perturbation of Notch signaling, CCs adopt distinct fates. Although the vast majority transdifferentiate into multiciliated cells, a “variant” subpopulation (v-CCs), juxtaposed to neuroepithelial bodies (NEBs; 5%–10%) and located at bronchioalveolar duct junctions (>80%), does not. Instead, v-CCs transition into lineage-ambiguous states but can revert to a CC fate upon restoration of Notch signaling and repopulate the airways with CCs and multiciliated cells. The v-CC response to …

Concordia Seminary Magazine Summer 2024, Vicki Biggs

Concordia Seminary Magazine

Joy Beyond Measure

Fieldnote 19: Intersection Of Mindfulness And Writing, Venus Evans-Winters Dr.

Fieldnotes of a Black Woman Scholar: Research, Culture, and Wellness

Recently, in our culture, there has been an overemphasis on writing for public consumption and profit. Academic writing privileges content that addresses "somebody else's problem" instead of writing for personal growth and imagination. This trend can overshadow the profoundly transformative potential of writing when it's approached as a tool for personal healing and authentic relationship building. Mindfulness awareness allows us to write from a place of authenticity and presence. As we observe our thoughts and emotions, we gain insights into our true selves, much like how staying present in the moment helps us navigate life's complexities. Dr. Venus Evans-Winters shares …