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Advances In The Radiation Therapy Of Carcinoma Of The Prostate, Joel Elliot White

Henry Ford Hospital Medical Journal

Basic principles of radiation biology and radiation tolerance are reviewed. The Implications for radiation therapy of newer staging techniques in carcinoma of the prostate such as exploratory laparotomy, lymphangiography, and bone marrow acid prosphatase are discussed. A technique for treating the prostate and para-aortic lymph nodes in continuity is presented. Complications and results of therapy are discussed.

Symposium On Carcinoma Of The Prostate — Introduction, Joseph C. Cerny

Henry Ford Hospital Medical Journal

No abstract provided.

Radionuclide Bone Imaging In The Evaluation Of Prostatic Cancer, Daniel S. Marks, William R. Eyler

Henry Ford Hospital Medical Journal

Radionuclide bone imaging is a rapid, easily performed, noninvasive method for evaluation of skeletal disease in carcinoma of the prostate, or any other malignancy. In a significant number of cases, it may provide the only evidence of metastases and frequently demonstrates more widespread Involvement than previously suspected. Thus, it may redirect the chosen course of therapy or localize sources of bone pain that are not radiographically apparent. Sixty-two percent of 42 patients studied were abnormal, of which 12% had no radiographic evidence of disease.

Bone Marrow Acid Phosphatase In The Evaluation Of Patients With Carcinoma Of The Prostate, Ronald Kabler, Riad Farah, Kenneth Greenawald, Joseph C. Cerny

Henry Ford Hospital Medical Journal

Based on experience with 30 men having clinical stage A and B adenocarcinoma of the prostate, the authors conclude that elevation of bone marrow acid phosphatase (BMAP) is a sensitive indicator of the disease state. BMAP revealed periprostatic or nodal Involvement when osseous metastases seemed absent. BMAP is considered essential in the evaluation of all patients with prostatic carcinoma. Patients who have false negative BMAP (and are not candidates for radical prostatectomy), should undergo lymphangiography and bone scan before radiation therapy or hormonal treatment is planned.

Immunologic Assessment In Patients With Prostatic Carcinoma, Richard C. Klugo

Henry Ford Hospital Medical Journal

The role of immune mechanisms in the development and control of prostatic carcinoma appears to be complicated by the endocrine response of some tumors. The progression of endocrine-independent tumors is more directly related to host-immune response. Evaluation of the role of chemotherapeutic agents must include their effect on the host-immune response. The use of BCC in patients with metastatic prostatic carcinoma produces no alteration in cell-mediated immunity but produces local tumor necrosis. The use of nonspecific antigens to enhance host-immune response may be more effective when used as adjuvant therapy in earlier stages of prostatic adenocarcinoma.

Hormonal And Chemotherapeutic Management Of Disseminated Carcinoma Of The Prostate, Robert W. Brownlee

Henry Ford Hospital Medical Journal

The management of disseminated prostatic carcinoma with hormonal and chemotherapeutic agents is discussed. Hormonal manipulation consists of ablative as well as additive modalities. A new agent, Adriamycin, has shown some effectiveness In selected cases. Significant difficulties are encountered in assessing the objective state of remission of patients undergoing therapy. Further advances through co-operative, randomized clinical trials must be sought. The development of additional chemotherapeutic agents will hopefully expand our horizons.

Changes In Serum Testosterone After Bilateral Orchiectomy In Patients With Metastatic Carcinoma Of The Prostate, Richard Senn, Riad Farah, Julius Ohorodnik, Joseph C. Cerny

Henry Ford Hospital Medical Journal

From a study of 38 patients, it may be concluded that, first, changes in serum testosterone levels of patients undergoing orchiectomy for metastatic carcinoma of the prostate are unrelated to the clinical course of the patient; second, no clear correlation exists between quantitative Leydig cell counts and levels of plasma testosterone; and, third, exacerbation of metastatic disease is observed while plasma testosterone remains in the castrate range. These observations question the exact function of the Leydig cell and its role in androgen production, and indicate that prostatic neoplasms have varying degrees of response to reduced androgen levels and/or androgen-Iike substances …

Atomic Models For The Polypeptide Backbones Of Myohemerythrin And Hemerythrin, W A Hendrickson, K B Ward

Faculty, Staff and Students Publications

Background: The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread rapidly after its identification in December 2019 to cause a global pandemic. The respiratory tract is the primary site of infection, and there is a large range in the severity of respiratory illnesses caused by the virus. Defining molecular and cellular factors for protection from severe disease and death has been a goal to better understand and to predict and mitigate the effects of SARS-CoV-2 and future coronaviruses.

Objective: Despite well-known susceptibilities to respiratory viral infections, respiratory allergy and allergic asthma have not been identified as risk factors …

The Effects Of Immobility On Long Bone Remodelling In The Rhesus Monkey, Charles C. Schock, Frank R. Noyes, Michael M. Crouch, Catharina H. E. Mathews

Henry Ford Hospital Medical Journal

Using Frost's method for undecalcified bone sections, long bones of the lower extremities of ten rhesus monkeys were examined following two months' immobilization and compared with thirteen controls. A decrease in appositional rate and in the surface extent of the ossification process were noted in the immobilized animals. No typical change in resorption was noted. The immobilized animals showed a decreased cortical-total area ratio. These findings suggest that a decrease in activity affects bone by depressing functions mediated by the osteoblast without necessarily evoking an Increased remodelling response.

Sjogren's Syndrome: Relationship Between Ocular Findings And Parotid Sialograms, A. O. Carbone, C. F. Petrozzi, J. Delcarpio, J. A. Zegarra

Henry Ford Hospital Medical Journal

This study evaluates the incidence and severity of the ocular findings and its correlation with the parotid gland changes, as demonstrated by sialography, in 82 patients with Sjogren's syndrome. It is shown that the ocular component of the syndrome manifests rather autonomously with respect to the accompanying collagen disease and that there seems to be only a tentative trend towards a positive correlation between the ocular and parotid findings. Sjogren's syndrome immunologically is closer to the collagen diseases than to the so-called organ-specific autoimmune diseases.

Publications Of The Staff Of The Henry Ford Hospital And The Edsel B. Ford Institute For Medical Research

Henry Ford Hospital Medical Journal

No abstract provided.

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Supportive Care Of The Leukemic Patient, Ellis J. Van Slyck

Henry Ford Hospital Medical Journal

The outlook for the patient with leukemia or lymphoma has been improved by the exponential expansion of basic scientific knowledge in physical chemistry and microbiology, added to much new clinical information based on large cooperative group studies. Most of this progress derives, not from a specific treatment for the disease, but from better understanding and use of multiple support measures. These include the availability of blood components, such as red blood cell, platelet and granulocyte concentrates, better protective isolation measures, and greater expertise in the recognition and treatment of bacterial, fungal, and viral infections in immunosuppressed patients. In addition, the …

Spontaneous Asymptomatic Pneumoperitoneum, Fernando Canavati, Thomas A. Fox Jr.

Henry Ford Hospital Medical Journal

A 65-year-old man developed a spontaneous asymptomatic pneumoperitoneum which was managed conservatively without exploratory laparotomy. However, the authors caution that repeated and careful examinations of the abdomen, observation of vital signs, and leucocyte counts must be made. Also, complete radiological examination of the gastrointestinal and respiratory tracts is necessary to eliminate a possible unrecognized lesion that might explain the origin of the spontaneous pneumoperitoneum.

Bacterial Endocarditis And Incarceration Of A Transvenous Pacemaker: Removal Under Cardiopulmonary By-Pass After Prolonged Traction Proved Ineffective, Remigio Garcia, Mehdi Hakimi-Naini

Henry Ford Hospital Medical Journal

Transvenous electrode endocardial pacing of the right ventricle is the most simple and common modality of permanent pacing at present. The incidence of endocarditis is rare. Only two patients were found in our hospital series of over 200 who had permanent transvenous pacemakers implanted. A 40-year-old housewife developed staphylococcus aureus endocarditis secondary to local wound infection in the power pack pocket, requiring removal of the infected electrode under cardiopulmonary by-pass. Prolonged traction of the retained electrode proved ineffective. The mechanism of electrode entrapment is discussed.

Congestive Cardiomyopathy As An End Stage Of Toxoplasma Myocarditis, Mohsin Alam, Wolf F. C. Duvernoy, Edward L. Quinn, Evelyn J. Fisher

Henry Ford Hospital Medical Journal

Congestive cardiomyopathy is a clinical entity which may be due to many different etiologies in addition to the primary type. The case presented defines the etiology in a 30-year-old patient as previous acute toxoplasma myocarditis. This diagnosis was corroborated by diagnostic rise of fluorescent antibody and Sabin-Feldman dye test titers and response to specific therapy. Toxoplasmosis has to be considered among the causes of congestive cardiomyopathy.

A Substance Abuse Prevention Plan Proposal For The State Of Michigan, William Lucien Macleod

Masters Theses

No abstract provided.

Moving Toward Integration: A Study Of Theory And Practice In Feminist Therapy, Susan Amelia Thomas

Dissertations and Theses

This thesis describes a study designed to explore the emerging field of feminist therapy. The goal was not to test the validity of feminist therapy, to probe the assumptions on which it is based, or to compare it to other forms of therapy but to characterize the theory and practice of feminist therapy as it now exists. Feminist therapy was seen as growing out of the cultural and historical context of the feminist movement, which includes a critique of society with emphasis on the particular psychological consequences for women, and a critique of psychotherapy, particularly Freudian psychotherapy, as oppressive to …

Amikacin: Clinical And Laboratory Studies, Erwin J. Haas, T. Madhavan, Evelyn J. Fisher, Frank Cox, Keith Burch, Edward L. Quinn, Richard D. Nichols

Henry Ford Hospital Medical Journal

Amikacin was evaluated in vitro against S aureus and a variety of gram negative bacilli. In concentrations of 12.5 μg/ml or less, it suppressed the growth of all organisms except 15% of Proteus mirabilis. Peak serum levels in patients, following a 7.5 mg/kg IM dose, averaged 21 μg/ml at one hour. Most of the drug appeared in the urine during the first six hours after administration. Of six patients receiving an adequate course of treatment, all but one were cured. Treatment in that patient also failed with a subsequent course of gentamicin and carbenicillin and he was cured only by …

The Bacteriology Of The Biliary Tract: A Preliminary Report., J. A. Sapala, J. L. Ponka, T. R. Neblett

Henry Ford Hospital Medical Journal

The bacterial flora of acute biliary tract disease has not been completely elucidated. The organisms identified most often were coliforms. Anaerobic culture technics were not precise enough to provide proper identification. In a 12-month study of 250 patients operated upon for inflammatory gallbladder disease, culture specimens were collected in a most strict and rigorous fashion. It was hoped that a more exact understanding of the relationship between bacteria and inflammatory biliary tract disease might be appreciated. Important technics were developed for gathering specimens, delivery to the laboratory and culturing. More meaningful results are to be expected In the future.

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Depth Doses In The Region Of Overlap Of The Supraclavicular And Internal Mammary Portals In Postoperative Radiation Therapy Of Carcinoma Of The Breast, Joel E. White, Michael Reidy, Murray Boles

Henry Ford Hospital Medical Journal

Computer-generated depth-dose data was obtained for the region of overlap of the internal mammary and supraclavicular portals utilized in post-operative radiation therapy for carcinoma of the breast. A phantom arrangement was created and measurements were obtained and compared with computer-generated depth doses for this arrangement. The actual measured and computer-generated values agreed to within 3%. On the patients measured at the center of the overlap region, the dose was found to vary from 3323 rets to 2571 rets over a depth range of 2-6 cm. It is occasionally the practice to ignore small areas of overlap. The dose at the …

Pseudo-Atrioventricular Block Due To Premature Systoles With Concealed Conduction, Boguslaw Godlewski, Wolf F. C. Duvernoy, Remigio Garcia

Henry Ford Hospital Medical Journal

Two patients are presented with EKC findings suggesting pseudo AV block Mobitz type II. Pseudo AV block was related to the presence of premature junctional or ventricular beats with concealed conduction. Response to therapy confirmed the initial diagnosis of pseudo AV block. Awareness of clinical conditions simulating type II second degree AV block is important because of the therapeutic implications and prognosis.

Utilization Of Mental Health Services For Children Relative To Social Class. A Pilot Study, H. K. Von Brauchitsch

Henry Ford Hospital Medical Journal

Two groups of children were selected from those evaluated and treated over a two-year period. The study attempted to contrast the mental health care needs and the health care delivery system of children from the uppermost classes against those of the lowest classes. Very few diagnostic discriminators were found. Prevalence of intellectual dysfunctions In the lower classes and neuroses in the upper classes did not correlate with behavior pattern of "acting out" or "acting in." Autistic psychoses were found almost exclusively among the upper classes; suicidality almost exclusively In the lower classes. Upper class children were more frequently referred by …

A Rapid Flexible Method For Determining Bile Lipids, William T. Beher, Grace J. Lin, Sofia Stradnieks

Henry Ford Hospital Medical Journal

A rapid flexible method has been developed for the quantitative determination of bile lipids In gallbladder and hepatic bile and duodenal aspirates. Quantification of bile salts involves separation of bile salt conjugates from one another and other bile lipids by thin layer chromatography. The separated salts are determined using 3-hydroxysteroid dehydrogenase and gas liquid chromatography. Cholesterol is determined in petroleum ether extracts of saponified bile by application of the Lieberman-Burchard reaction. Phospholipid phosphorus is determined in purified bile lipid extracts by oxidation followed by application of Bartlett's modification of the Fiske- SubbaRow method.

Commencement Program 1975, Loma Linda University

Commencement Programs

CONTENTS

2 | 1975 Events of Commencement

3 | Conferring of Degrees

7 | Candidates for Degrees

25 | Awards

26 | Academic Costume

29 | Waymarks

A Descriptive Study Of Women's Attitudes Towards Obtaining Or Not Obtaining Papanicolaou Smears, Linda J. Shults

Loma Linda University Electronic Theses, Dissertations & Projects

It was the purpose of this study to identify the attitudes of a selected group of women which influenced their participation in Papanicolaou testing. These attitudes were inferred from the reasons women gave for obtaining the test. The subjects were randomly selected from the telephone book of a medium-sized town in Southern California. The 135 women who participated in the telephone interview were considered to be the respondents in the study.

A review of the literature revealed that through the annual use of the Papanicolaou smear, approximately 11,000 deaths every year from uterine and cervical cancer could be prevented, Attitudes …

Marital Status As A Discriminator And Treatment Variable Among Female Alcoholics, James C. Knapp

Dissertations and Theses

In this study marital status and the alcoholism or non-alcoholism of the spouse are hypothesized to be important factors affecting the female alcoholic's personality and treatability.

Chapel Transcript: Announcement Of The Oru School Of Medicine 4-8-1975, Oral Roberts

Chapel AV & Transcripts

The announcement by President Oral Roberts to the student body of Oral Roberts University that ORU plans to launch a School of Medicine led by Dr. James Winslow. He also announced other graduate schools: School of law, School of Business, School of Dentistry, School of Theology.

Informed Consent And Medical Experimentation, George H. Martin Jr.

IUSTITIA

Certain biomedical technologies already or almost already with us "threaten to reduce the meaning of man and to degrade the human spirit in the very process of becoming technologically feasible, long before the final stage of deployment and widespread use has been reached." It is this threat that has prompted me to consider certain medical and legal problems associated broadly with the human experimentation process. I shall be examining the concept of "informed consent" to both experimental medical therapy and nontherapeutic scientific experimentation as a means of protecting man from the potential ravages of a zealous application of scientific advances …