Digital Commons Network^™

Halo Ion Trap Mass Spectrometry: Design, Instrumentation, And Performance, Miao Wang

Theses and Dissertations

New ion trap mass spectrometry (ITMS) instrumentation, the toroidal IT and halo IT, were developed to meet the significant growth in on-site analysis applications. The miniature toroidal IT mass analyzer was operated with radio frequency (RF) trapping voltages of 3 kVp-p or less. Despite its reduced dimensions, it has roughly the same ion trapping capacity as conventional 3D quadrupole ITs. Unit-mass resolved spectra for n-butylbenzene, xenon, and naphthalene were obtained. The desired linear mass scale was obtained using conventional mass-selective instability scan combined with resonance ejection. The halo IT was also based on toroidal trapping geometry and microfabrication technology, consisting …

Autonomous Underwater Vehicles As Tools For Deep-Submergence Archaeology, Christopher N. Roman, Ian Roderick Mather

Graduate School of Oceanography Faculty Publications

Marine archaeology beyond the capabilities of scuba divers is a technologically enabled field. The tool suite includes ship-based systems such as towed side-scan sonars and remotely operated vehicles, and more recently free-swimming autonomous underwater vehicles (AUVs). Each of these platforms has various imaging and mapping capabilities appropriate for specific scales and tasks. Broadly speaking, AUVs are becoming effective tools for locating, identifying, and surveying archaeological sites. This paper discusses the role of AUVs in this suite of tools, outlines some specific design criteria necessary to maximize their utility in the field, and presents directions for future developments. Results are presented …

The Design And Synthesis Of Functionalized Porphyrins And Their Applications In Group Transfer Reactions, Medicine, And Materials, Kimberly Bliss Fields

USF Tampa Graduate Theses and Dissertations

Porphyrins and their analogs are a class of chemically and biologically important compounds that have found a variety of applications in different fields such as catalysis, medicine, and materials. The physical, chemical, and biological dependence of the peripheral substituents of porphyrins on their properties has prompted great effort towards the synthesis of new porphyrins with different electronic, steric, and conformational environments. To this end, porphyrins have been prepared using a modular approach from bromo- and triflate synthons. These synthons underwent palladium-catalyzed cross-coupling with chiral amines, amides, alcohols, and boronic esters to create products that were tested for biological activity.

Metalloporphyrins …

Chemistry & Biochemistry Newsletter, Department Of Chemistry & Biochemistry, South Dakota State University

Chemistry & Biochemistry Newsletter: 2002-2015

Inside:

Page 2 Career Award Will Help Build High-Tech Microscope

Page 4 Classroom Changes; Krsnak Wins Oz Memorial

Page 5 Chemistry Major John Lee is Academic All-American

Page 6 Program to Address Shortage of Medical Lab Scientists

Page 7 New Graduate Students

Page 8 Publications and Grants

Hijacking User Uploads To Online Persistent Data Repositories For Covert Data Exfiltration, Curtis P. Barnard

Theses and Dissertations

As malware has evolved over the years, it has gone from harmless programs that copy themselves into other executables to modern day botnets that perform bank fraud and identity theft. Modern malware often has a need to communicate back to the author, or other machines that are also infected. Several techniques for transmitting this data covertly have been developed over the years which vary significantly in their level of sophistication. This research creates a new covert channel technique for stealing information from a network by piggybacking on user-generated network traffic. Specifically, steganography drop boxes and passive covert channels are merged …

Determination Of Cyanide Exposure By Gas Chromatography–Mass Spectrometry Analysis Of Cyanide-Exposed Plasma Proteins, Stephanie L. Youso, Gary A. Rockwood, John A. Lee, Brian A. Logue

Chemistry and Biochemistry Faculty Publications

Exposure to cyanide can occur in a variety of ways, including exposure to smoke from cigarettes or fires, accidental exposure during industrial processes, and exposure from the use of cyanide as a poison or chemical warfare agent. Confirmation of cyanide exposure is difficult because, in vivo, cyanide quickly breaks down by a number of pathways, including the formation of both free and protein-bound thiocyanate. A simple method was developed to confirm cyanide exposure by extraction of protein-bound thiocyanate moieties from cyanide-exposed plasma proteins. Thiocyanate was successfully extracted and subsequently derivatized with pentafluorobenzyl bromide for GC–MS analysis. Thiocyanate levels as low …

Preconference Proceedings On Advances In Adaptive Planning Capabilities, Jens G. Pohl

Collaborative Agent Design (CAD) Research Center

No abstract provided.

Solving The Data Deluge Problem, Jens G. Pohl

Collaborative Agent Design (CAD) Research Center

The paper postulates that the information technology revolution that is commonly referred to as the Information Age is currently in a transition stage between data-processing and knowledge management that should be more aptly referred to as the Data Age. Symptoms of this transition stage are a data deluge problem that is evidenced by the inability of human computer-users to effectively analyze and draw useful conclusions from the overwhelming volume of data that is being collected, the increasing complexity of networked systems, and the acknowledged vulnerability of virtually all existing digital systems to cyber security threats.

The author suggests that the …

High Pressure Liquid Chromatography Studies Of The Reaction Of Platinum Complexes With Peptides, Khaja Muneeruddin

Masters Theses & Specialist Projects

Platinum complexes (cisplatin, carboplatin and oxaliplatin) are effective anticancer agents. However the major drawbacks of platinum chemotherapy are toxic side effects and resistance. The affinity of platinum complexes to sulfur donor ligands of side chains of methionine and cysteine amino acids was assumed to be responsible for toxicity and resistance. Recently, it was found that the reaction of platinum complex with proteins containing sulfur donor ligands could actually favor its anticancer activity. Copper transporter 1 (Ctr 1), a protein involved in the transport of copper into the cell, also helps in the influx of cisplatin by binding to N-terminal domain …

Malware Type Recognition And Cyber Situational Awareness, Thomas E. Dube, Richard A. Raines, Gilbert L. Peterson, Kenneth W. Bauer, Michael R. Grimaila, Steven K. Rogers

Faculty Publications

Current technologies for computer network and host defense do not provide suitable information to support strategic and tactical decision making processes. Although pattern-based malware detection is an active research area, the additional context of the type of malware can improve cyber situational awareness. This additional context is an indicator of threat capability thus allowing organizations to assess information losses and focus response actions appropriately. Malware Type Recognition (MaTR) is a research initiative extending detection technologies to provide the additional context of malware types using only static heuristics. Test results with MaTR demonstrate over a 99% accurate detection rate and 59% …

Hrc Enews — 2010 Summer, Megan K. Svarz

Publications (HRC)

This issue contains staff accomplishments and announcements, event listings, and a "new faces" listing for new staff, affiliates, and researchers.

Novel Π-Conjugated Materials Plus Their Characterizations And Applications, Xiuxian He

All Dissertations

The theme of this dissertation will focus on the syntheses and characterization of bipyridine (bipy) containing π-conjugated polymers (CPs). Specifically, poly(p-phenylene ethynylene), polyfluorene and poly(p-phenylene vinylene) derivatives have been prepared via Sonogashira coupling, Suzuki coupling and Heck coupling, respectively. Derivatives of poly(p-phenylene ethynylene), polyfluorene and poly(p-phenylene vinylene) are known to have applications in optical and electronic devices. Through this study, polymers condensed with bulky bipy-containing TAB as one of the copolymer units have shown increased solubility and diminished intrachain/interchain aggregation in solution and in film due to the effectiveness of TAB in controlling the relative orientations of individual polymer chains. …

Short-Chain Carboxylic Acids From Gray Catbird (Dumetella Carolinensis) Uropygial Secretions Vary With Testosterone Levels And Photoperiod, Rebecca J. Whelan, Tera C. Levin, Mary C. Garvin

Faculty & Staff Scholarship

The uropygial gland of birds produces secretions that are important in maintaining the health and structural integrity of feathers. Non-volatile components of uropygial secretions are believed to serve a number of functions including waterproofing and conditioning the feathers. Volatile components have been characterized in fewer species, but are particularly interesting because of their potential importance in olfactory interactions within and across species. We used solid-phase microextraction headspace sampling with gas chromatography-mass spectrometry to detect and identify volatiles in uropygial secretions of gray catbirds (Dumetella carolinensis), a North American migratory bird. We consistently detected the following carboxylic acids: acetic, …

Fluorescent Chemosensors For Toxic Organophosphorus Pesticides: A Review, Sherine O. Obare, Chandrima De, Wen Guo, Tajay L. Haywood, Tova A. Samuels, Clara P. Adams, Noah O. Masika, Desmond H. Murray, Ginger A. Anderson, Keith Campbell, Kenneth Fletcher

Faculty Publications

Many organophosphorus (OP) based compounds are highly toxic and powerful inhibitors of cholinesterases that generate serious environmental and human health concerns. Organothiophosphates with a thiophosphoryl (P=S) functional group constitute a broad class of these widely used pesticides. They are related to the more reactive phosphoryl (P=O) organophosphates, which include very lethal nerve agents and chemical warfare agents, such as, VX, Soman and Sarin. Unfortunately, widespread and frequent commercial use of OP-based compounds in agricultural lands has resulted in their presence as residues in crops, livestock, and poultry products and also led to their migration into aquifers. Thus, the design of …

Realistic Vertical Atmospheric Profiles And Effects From Limited Surface Observations, Dane P. Ranney

Theses and Dissertations

The ability to accurately describe the atmospheric conditions around us is not only important to the Air Force, but to anyone involved in signal propagation. The programs currently utilized to describe the atmosphere take into account a variety of measures. The LEEDR (Laser Environmental Effects Definition and Reference) program in particular, allows the user to select a location, aerosol and molecular effects model, numerous cloud and precipitation events, as well as other features. Even with the control that the user has, the output that the program provides can vary from actual conditions on a day to day basis. This is …

The Combined Effects Of Radio Frequency And Gamma Irradiation On P-Channel Mosfets, Joshua D. Daniel

Theses and Dissertations

The purpose of this research was to investigate the combined effects of continuous gigahertz radio frequency signals and gamma irradiation on the threshold voltage of metal oxide semiconductor field effect transistors. The combined effects of gigahertz radio frequency waves and gamma irradiation on electronics presents a new challenge in electronic warfare and little is known of the combined effect on threshold voltage damage and recovery. The Fairchild NDS352AP, a commonly used commercial device, was irradiated by a cobalt-60 source under a +5 V bias with and without a radio frequency signal applied to the gate. The threshold voltage was measured …

Developing A Hybrid Virtualization Platform Design For Cyber Warfare And Simulation, Kyle E. Stewart

Theses and Dissertations

Virtualization is a technique used to model and simulate the cyber domain, as well as train and educate. Different types of virtualization techniques exist that each support a unique set of benefits and requirements. This research proposes a novel design that incorporates host and network virtualization concepts for a cyber warfare training platform. At the host level, hybrid virtualization combines full and operating system virtualization techniques in order to leverage the benefits and minimize the drawbacks of each individual technique. Network virtualization allows virtual machines to connect in flexible topologies, but it also incurs additional processing overhead. Quantitative analysis falls …

Change Management In A Dynamic Information Technology Environment: Inquiries Into The Adkar Model For Change Management Results, Michael S. Lowery

Regis University Student Publications (comprehensive collection)

Change in our lives is an ongoing, complex, and difficult process that cannot be avoided, and in order for any organization comprised of people to be successful, change must be managed. There are many documented instances of organizations failing in their change efforts, and it is not always the technology that causes change failures, but it is the people aspect towards change that is neglected. This paper focuses on the ADKAR model which is a sequential and cumulative goal-oriented change management model with targeted results and consists of the elements Awareness, Desire, Knowledge, Ability, and Reinforcement, and how the model …

A Synthetic Approach Toward Novel Β-Lactams, Mohamed Hashim

Theses and Dissertations - UTB/UTPA

β-lactam antibiotics which is a class by itself, covers a wide range of antibiotics that includes penicillin, penicillin derivatives, cephalosporins, carbapenems, and any antibiotic agent that contains a 2-azetidinone ring.[2] In recent past research it has been established that β-lactams show therapeutic and anticancer activity with low toxicity. [2] It has also been reported by our lab that N-chrysenyl and N-phenanthrenyl 3-acetoxy-4-aryl-2- azetidinone can exhibit potent selective anticancer activity towards prostate, colon, pancreatic cancer and leukemia at low concentrations, all of this was revealed by means of a structure activity study. [2] The goal of our research is the synthesis …

Bacillus Cereus And Bacillus Anthracis Germination Kinetics: A Michaelis-Menten Approach, Helen Luu

UNLV Theses, Dissertations, Professional Papers, and Capstones

Bacillus species are rod-shaped, gram-positive bacteria that are capable of producing endospores. In this dormant stage, the endospores can persist in hostile physical and chemical environments. Once conditions become favorable, the spores germinate into actively dividing cells, vegetative cells. Germination is a crucial step for the pathogenicity of the Bacilli in affecting a host organism.

Our study applies mathematical approaches to spore germination to determine whether the binding of one germinant will affect the binding of another germinant. We pursued this approach with two different species, B. cereus and B. anthracis, both pathogenic organisms. B. cereus is a widely known …

Designing Molecular And Nanoscale Materials For Environmental Chemistry Processes, Wen Guo

Dissertations

This dissertation focuses on fundamental studies to identify materials that detect and degrade common organic environmental pollutants. Chapter 1 represents the overview of two widespread ground water contaminants: organohalides and organophosphorous compounds. Due to continuous usage of these compounds as well as their toxicity, reliable and sensitive methods for their detection and degradation are urgently needed. In Chapter 2 a description of molecular sensors designed with high sensitivity and selectivity to detect and distinguish between three organophosphorus (OP) pesticides are described. These sensors provide dual optical and electrochemical signals for detection, which minimizes false-positives. The signal transduction occurs in real …

The Integration Of Biomimicry Into A Built Environment Design Process Model: An Alternative Approach Towards Hydro-Infrastructure, Timothy Lee Albertson

UNLV Theses, Dissertations, Professional Papers, and Capstones

Current methods and processes that support the planning, design and construction of a sustainable built environment include ambiguous principles (Roseland 2000), lack feedback loops (Van Bueren and Jong 2007) and lack a common language between disciplines (Brandon et al 1997). As a result of 3.8 billion years of "research and development" (evolution), nature provides a set of design blueprints that may be used to guide us to create elegant, sustainable, and innovative designs for human technologies (Benyus 1997). The field of biomimicry analyzes nature's best ideas and adapts them for human use (Benyus 1997). The built environment could benefit from …

Not Empty, Lauren Orme

Scripps Senior Theses

Not Empty is a two- part exploration of the relationship between humans and nature. In this essay I intend to discuss the relationship Australian Aboriginal peoples have with their environment. Their many cultures are among the oldest surviving civilizations on the planet, and their natural history is rich and complex. I plan to compare the relationship Australian Aboriginal cultures have to their environment to that of a Western civilization, specifically the United States. Neither relationship is perfect, nor is one of them 'better.' Both have histories riddled with extinction, evolution, and the conquest of new lands. The struggle Aboriginal Australians …

Analysis Of Streamflow In The St. Croix River: A Hydrologic Model, Stephanie A. Kleinschmidt

Geography Honors Projects

This project assesses how streamflow is affected by anthropogenic changes to the environment, looking specifically at the St. Croix River Basin. In 2004 the United States Geologic Survey (USGS) published a report on streamflow in the St. Croix River at two gaging stations: Danbury and St. Croix Falls. The streamflow at the upstream station near Danbury, Wisconsin remained stable over time, while an increase was observed at the station in St. Croix Falls, Wisconsin further downstream. In order to evaluate this disparity, this project utilizes a GIS hydrologic model to analyze the factors expected to be influencing the flow rate. …

Handshaking Protocols And Jamming Mechanisms For Blind Rendezvous In A Dynamic Spectrum Access Environment, Aaron A. Gross

Theses and Dissertations

Blind frequency rendezvous is an important process for bootstrapping communications between radios without the use of pre-existing infrastructure or common control channel in a Dynamic Spectrum Access (DSA) environment. In this process, radios attempt to arrive in the same frequency channel and recognize each other’s presence in changing, under-utilized spectrum. This paper refines existing blind rendezvous techniques by introducing a handshaking algorithm for setting up communications once two radios have arrived in the same frequency channel. It then investigates the effect of different jamming techniques on blind rendezvous algorithms that utilize this handshake. The handshake performance is measured by determining …

Screening And Sufficiency In Multiobjective Decision Problems With Large Alternative Sets, Michael D. Cote

Theses and Dissertations

Portfolio selection problems with combinatorially-large alternative sets can be impossible to evaluate precisely on a reasonable timescale. When portfolios require complex modeling for performance assessment, prohibitive computational processing times can result. Eliminating a small number of alternatives through an intelligent screening process can greatly reduce the number of alternative combinations, thereby decreasing a problem's evaluation time and cost. A methodology was developed for the class of hierarchical portfolio selection problems in which multiple objectives are all judged on the same sub-objectives. First, a novel capability-based alternative screening process was devised to identify and remove poor alternatives, thereby reducing the number …

The Uav Continuous Coverage Problem, Taegyun Ha

Theses and Dissertations

The purpose of this research is to develop a method to find an optimal UAV cyclic schedule to provide maximum coverage over a target area to support an ISR mission. The goal is to reach continuous coverage. UAV continuous coverage of a target area is crucial for the success of an ISR mission. Even the smallest coverage gap may jeopardize the success of the mission. Ideally it is desirable to obtain continuous coverage of a target area but the stochastic nature of the problem makes continuous coverage without gaps unlikely. However, it is still possible to obtain a high coverage …

Visually Managing Ipsec, Peter J. Dell'accio

Theses and Dissertations

The United States Air Force relies heavily on computer networks to transmit vast amounts of information throughout its organizations and with agencies throughout the Department of Defense. The data take many forms, utilize different protocols, and originate from various platforms and applications. It is not practical to apply security measures specific to individual applications, platforms, and protocols. Internet Protocol Security (IPsec) is a set of protocols designed to secure data traveling over IP networks, including the Internet. By applying security at the network layer of communications, data packets can be secured regardless of what application generated the data or which …

Developing Cyberspace Data Understanding: Using Crisp-Dm For Host-Based Ids Feature Mining, Joseph R. Erskine

Theses and Dissertations

Current intrusion detection systems generate a large number of specific alerts, but do not provide actionable information. Many times, these alerts must be analyzed by a network defender, a time consuming and tedious task which can occur hours or days after an attack occurs. Improved understanding of the cyberspace domain can lead to great advancements in Cyberspace situational awareness research and development. This thesis applies the Cross Industry Standard Process for Data Mining (CRISP-DM) to develop an understanding about a host system under attack. Data is generated by launching scans and exploits at a machine outfitted with a set of …

Utilizing The Digital Fingerprint Method For Secure Key Generation, Jennifer C. Anilao

Theses and Dissertations

This research examines a new way to generate an uncloneable secure key by taking advantage of the delay characteristics of individual transistors. The user profiles the circuit to deduce the glitch count of each output line for each number of selectable buffers added to the circuit. The user can then use this information to generate a specific glitch count on each output line, which is passed to an encryption algorithm as its key. The results detail tests of two configurations for adding a selectable amount of buffers into each glitch circuit in order to induce additional delay. One configuration adds …