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Full-Text Articles in Entire DC Network
A Fault Tolerant Honeybee Behaviour Load Balancing Algorithm, Charmaine Adegbite
A Fault Tolerant Honeybee Behaviour Load Balancing Algorithm, Charmaine Adegbite
Tennessee State University Alumni Theses and Dissertations
Cloud computing enables flexible, scalable access to virtualised infrastructure but remains challenged by maintaining performance in fault-prone environments. Faults such as virtual machine failures can degrade task allocation and system reliability. However, traditional load balancing algorithms and bio-inspired strategies, including the Honeybee Behaviour Load Balancing algorithm, assume fault-free conditions. This thesis introduces a Fault-Tolerant Honeybee Behaviour Load Balancing algorithm that enhances the original Honeybee Behaviour Load Balancing algorithm by integrating fault detection. The proposed algorithm monitors the health of VMs and dynamically reallocates workloads when faults are detected which improves stability and reliability. The proposed fault tolerant algorithm was implemented …
Interactive Effects Of Warming And Nitrogen Fertilization On Soil Respiration And Microbial Community Function, Aviyan Pandey
Interactive Effects Of Warming And Nitrogen Fertilization On Soil Respiration And Microbial Community Function, Aviyan Pandey
Tennessee State University Alumni Theses and Dissertations
Understanding the effects of multiple global change drivers, e.g., warming (W) and nitrogen (N) fertilization, is critical for accurately predicting ecosystem responses to climate change. This study investigates the main and interactive effects of soil warming and N fertilization on soil organic carbon (SOC), total nitrogen (TN), microbial biomass, extracellular enzyme activities (EEAs), and soil respiration (Rs) in a switchgrass (Panicum virgatum) cropland located in Middle Tennessee, U.S. The field experiment employed a split-plot design with two levels of warming (ambient and heated) and two levels of N fertilization (zero and 168 kg N ha-1yr-1). Hourly measurements of Rs, soil …
The Chemistry Of Color: A Comparative Analysis Of Natural And Synthetic Dyes In Textile Application, Caitlyn Pinaga Cpht
The Chemistry Of Color: A Comparative Analysis Of Natural And Synthetic Dyes In Textile Application, Caitlyn Pinaga Cpht
Honors Program Theses and Research Projects
The Chemistry of Color: A Comparative Analysis of Natural and Synthetic Dyes in Textile Application examines how color functions at the intersection of chemistry, culture, and environmental responsibility. This project traces the evolution of dyeing from ancient natural pigment traditions, rooted in ecological knowledge, agricultural practices, and cultural identity, to the industrial rise of synthetic dyes, whose laboratory precision enabled unprecedented consistency, brightness, and global textile expansion. Through experimental swatch analysis, the study compares the behavior of natural dyes derived from plants and food sources with modern fiber-reactive and synthetic dye classes on a range of fibers including cotton, bamboo …
High-Resolution Lidar Observations Of Sedimentation-Induced Size Sorting Of Droplets Near A Laboratory Cloud Top, Fan Yang, Yong Meng Sua, Zipei Zheng, Jesse Anderson, Hamed F. Sadi, Jae Min Yeom, Suryadev Pratap Singh, Pei Hou, Will Cantrell, Ernie Lewis, Alex Kostinski, Raymond Shaw
High-Resolution Lidar Observations Of Sedimentation-Induced Size Sorting Of Droplets Near A Laboratory Cloud Top, Fan Yang, Yong Meng Sua, Zipei Zheng, Jesse Anderson, Hamed F. Sadi, Jae Min Yeom, Suryadev Pratap Singh, Pei Hou, Will Cantrell, Ernie Lewis, Alex Kostinski, Raymond Shaw
Michigan Tech Publications
No abstract provided.
White Nose Syndrome In Bats And Infant Mortality In Georgia, Rhys Medcalfe, Sean Medcalfe, Simon Medcalfe
White Nose Syndrome In Bats And Infant Mortality In Georgia, Rhys Medcalfe, Sean Medcalfe, Simon Medcalfe
Journal of the Georgia Public Health Association
Background: White nose syndrome (WNS) is a disease in bats caused by the fungus Pseudogymnoascus destructans that can result in bat mortality rates of over 90%. WNS was discovered in Georgia in 2012 in 3 counties but has continued to spread to 14 counties as of 2023, with P. destructans detected in a further seven. Biodiversity loss has been linked to human health outcomes including infant mortality. Understanding the link between WNS, biodiversity loss, and infant mortality in Georgia is important because Georgia ranks 42nd out of the 50 states for infant mortality rate.
Methods: Using panel data from …
A Sedimentary Source Of Rare Earth Elements In The North Atlantic, Rylee D. Lindner
A Sedimentary Source Of Rare Earth Elements In The North Atlantic, Rylee D. Lindner
Electronic Theses and Dissertations
Individually and as a series, the Rare Earth Elements (REEs) are powerful geochemical tracers of environmental processes. However, ambiguities in the oceanic budgets of the REEs hamper their application. Growing evidence suggests a sedimentary benthic flux via the pore water is the major source of REEs to the ocean, with extrapolated estimates of this flux being equivalent in magnitude to that “missing” from modern budgets. However, existing pore water REE data are available from only a few locations globally with no representative dataset from the open North Atlantic. This data scarcity limits our ability to constrain flux estimates and understand …
Book Of Abstracts, Seton Hall University
Book Of Abstracts, Seton Hall University
2025 Augustine Undergraduate Research Symposium
No abstract provided.
Citizen's Rare Plant Watch 2025 Recap, Nora Dunkirk
Citizen's Rare Plant Watch 2025 Recap, Nora Dunkirk
Rae Selling Berry Seed Bank and Plant Conservation Program
Citizen's Rare Plant Watch (CRPW) is a community science program which takes volunteers out to visit populations of rare and threatened Oregon native plant species. Volunteers assess their health and viability, update the Oregon Biodiversity Information Center (ORBIC) state database for rare species, and help contribute to data driven management decisions throughout the state. Housed at Portland State University, this program is open to the public and attracts plant lovers from diverse backgrounds. Each spring, CRPW trains volunteers on methods of data collection, and this year we implemented new technology using Survey123 to streamline population assessments. We focus on species …
Sustainable Polyaddition Path To Polyesters Via Catalytic Homocoupling Of Renewable Dicrotonate Monomers, Shabbir Asif, Mahsa Saeidi, Braden D. Pickle, Nicholas J. Tabbah, Michael L. Mcgraw
Sustainable Polyaddition Path To Polyesters Via Catalytic Homocoupling Of Renewable Dicrotonate Monomers, Shabbir Asif, Mahsa Saeidi, Braden D. Pickle, Nicholas J. Tabbah, Michael L. Mcgraw
Chemistry & Biochemistry Faculty Publications and Presentations
The development of biorenewable polyhydroxyalkanoate (PHA) chemistry has generated interest in crotonate-based monomers as versatile building blocks. Crotonates can be obtained through the pyrolysis of PHAs, offering both a sustainable end-of-life pathway for PHAs and a renewable route to crotonate monomers. This study presents a new polyaddition-type step-growth polymerization of dicrotonates in which alkene-functionalized polyesters are synthesized using potassium tert-butoxide as a simple base catalyst. The reaction proceeds rapidly at room temperature, achieving >99% conversion within seconds and requiring no byproduct removal. The properties of the resulting polyesters can be tuned via the choice of bridging diol, and the materials …
Engineered Multifunctional Drug-Loaded Dendrimer Nanoparticles For Glaucoma: Triple Mechanism Via Antioxidant Activity, Iron Chelation, And Enhanced Ocular Transport, Burhan Ates, Ashish Trital, Vimalin Jeyalatha Mani, Lei Xu, Jonathan Kenlee, Nuran Ercal, Hu Yang
Engineered Multifunctional Drug-Loaded Dendrimer Nanoparticles For Glaucoma: Triple Mechanism Via Antioxidant Activity, Iron Chelation, And Enhanced Ocular Transport, Burhan Ates, Ashish Trital, Vimalin Jeyalatha Mani, Lei Xu, Jonathan Kenlee, Nuran Ercal, Hu Yang
Chemistry Faculty Research & Creative Works
In this study, we developed multifunctional nanoparticles based on polyamidoamine (PAMAM) dendrimers functionalized with caffeic acid (CA) and poly (ethylene glycol) maleimide (PEGM) for the topical delivery of hydrophobic antiglaucoma drugs brimonidine (BM) and betaxolol (BX). The PAMAM-CA and PAMAM-CA-PEGM conjugates exhibited antioxidant and iron-chelating activities in a dose-dependent manner. BM- and BX-loaded dendrimer nanoparticles produced using a multi-inlet vortex mixer showed uniform spherical morphology (∼80 nm by TEM) and hydrated sizes of ∼135-144 nm by DLS. Both nano formulations demonstrated high cytocompatibility with human corneal epithelial cells and were nonirritant in the HET-CAM assay, with PEGM further improving cytocompatibility. …
Collaborative Research: Cif: Medium: Foundations Of Robust Deep Learning Via Data Geometry And Dyadic Structure, Kevin Moon
Funded Research Records
No abstract provided.
Time-Resolved Ultrafast Infrared Spectroscopic Interrogation Of Intramolecular Reaction Coordinates, Valerie Winkler
Time-Resolved Ultrafast Infrared Spectroscopic Interrogation Of Intramolecular Reaction Coordinates, Valerie Winkler
Arts & Sciences Graduate Student Theses and Dissertations
Light-induced chemical transformations are practical across many chemical and biological systems. From intramolecular hydrogen-bonding coordinates to reactions which alter the carbon framework of a molecule, the application of light can induce conformational changes that can subsequently be harnessed for a variety of tasks. However, molecular-level mechanistic insight about photo-induced chemical reactions remains difficult to acquire using current methodologies. In this dissertation, several intramolecular reactions are investigated and characterized, ranging from ground- and excited-state intramolecular proton transfers to the photochemical synthesis of a complex organic cyclization structure. The reaction coordinates are directly interrogated by utilizing ultrafast infrared spectroscopic techniques, such as …
Wf-2453 Post-Wildfire Hydrogeomorphic Risk Management Assessment, Belize A. Lane
Wf-2453 Post-Wildfire Hydrogeomorphic Risk Management Assessment, Belize A. Lane
Funded Research Records
No abstract provided.
Buffer Vs. Swabs: Efficacy Of Carrier Nucleic Acids In Robotic Extractions, Shawn Cecil
Buffer Vs. Swabs: Efficacy Of Carrier Nucleic Acids In Robotic Extractions, Shawn Cecil
Honors Projects
This study compared the efficiency of two carrier nucleic acid methods, specifically using salmon sperm DNA (spDNA), in robotic solid-phase extractions of cotton swab samples. Robotic extractions reduce processing time and workload but result in substantially lower DNA recovery than manual organic extraction. This research tested 10 µg of spDNA being added to the lysis buffer or pre-treating the swabs with it before DNA was added. Both methods showed a significant increase in recovery compared to extractions with no carrier. In the buffer extractions, recovery ranged from 69.4% to 117.5% and the swabs being pre-treated ranged from 84.2% to 125.8% …
Adaptive Image Acquisition Algorithms For Resource-Constrained Single-Photon Cameras, Yeganeh Jalalpour, Wu-Chi Feng
Adaptive Image Acquisition Algorithms For Resource-Constrained Single-Photon Cameras, Yeganeh Jalalpour, Wu-Chi Feng
Computer Science Faculty Publications and Presentations
Emerging single-photon camera (SPC) technologies have unique challenges in data acquisition and processing. Unlike conventional sensors that produce a single 8- to 16-bit brightness value per pixel, SPCs record photon arrivals with many more samples per pixel, using high floating-point precision for each photon collected. This means that they must handle potentially millions of timestamps, especially at higher spatial resolutions and in the presence of ambient light, creating bottlenecks within the pixel circuitry. To address these challenges associated with SPCs, this paper proposes adaptive algorithms designed to efficiently distribute hardware resources among groups of pixels. By selectively subsampling the data …
Dynamic, Reconfigurable, And Hierarchical Biosynthetic Composites Via Collagen Self-Assembly Within Highly Crowded Microgel Pastes, Elif Narbay, Abbygail Caine, Sanika Pandit, Gabrielle Montgomery, Marion Harper, E. Daniel Cárdenas-Vásquez, Hatte Hamilton, Megan Hicks, Daniel Mattar, Kyle Choy, Marco Bisoffi, L. Andrew Lyon
Dynamic, Reconfigurable, And Hierarchical Biosynthetic Composites Via Collagen Self-Assembly Within Highly Crowded Microgel Pastes, Elif Narbay, Abbygail Caine, Sanika Pandit, Gabrielle Montgomery, Marion Harper, E. Daniel Cárdenas-Vásquez, Hatte Hamilton, Megan Hicks, Daniel Mattar, Kyle Choy, Marco Bisoffi, L. Andrew Lyon
Engineering Faculty Articles and Research
The fabrication of a new class of biomimetic biomaterials is reported using nanostructured microgel pastes formed from “overpacked” assemblies of ultrasoft poly(N-isopropyl acrylamide-co-acrylic acid) microgels and their composites with collagen. Despite the solid-like nature of microgel pastes, collagen fibrillogenesis is robust and rapid, with a 3D collagen network forming throughout the paste volume. Structural organization within the composite is interrogated via a suite of microscopy methods, while rheological characterization provides insight into the static and dynamic mechanical properties of the materials. Long-range fibrillogenesis is enabled by local crowding, dynamics, and spatial reconfigurability of pastes at the …
A (Mini) Mathematics Research Experience In A Math Teachers’ Circle Session, Michelle Manes, Linda Venenciano, Seanyelle Yagi
A (Mini) Mathematics Research Experience In A Math Teachers’ Circle Session, Michelle Manes, Linda Venenciano, Seanyelle Yagi
Journal of Math Circles
We describe a single Math Teachers’ Circle session during which a group of teachers collectively engaged in a “mini mathematics research experience.” This provides a model for providing research experiences for mathematics teachers through content-based professional development programs. We conjecture that these experiences will have many of the same benefits as research experiences for teachers in lab sciences.
Environmental Risk Assessment Of Textile Waste From Bio-Engineered Fibers In The Fashion Industry, Aayush Pankaj Agarwal, Harshit Soral, Irmak Aktan, Karol Montserrat Gonzalez Saad, Maria Daniela Saa Espinosa, Sheetal Suhas Dhanuka, Yi Yang
Environmental Risk Assessment Of Textile Waste From Bio-Engineered Fibers In The Fashion Industry, Aayush Pankaj Agarwal, Harshit Soral, Irmak Aktan, Karol Montserrat Gonzalez Saad, Maria Daniela Saa Espinosa, Sheetal Suhas Dhanuka, Yi Yang
Harrisburg University Dissertations and Theses
The global fashion industry generates over 92 million tons of textile waste annually, a figure projected to increase significantly by 2030. Bio-engineered fibers, including bacterial cellulose, mycelium-based leather, and recombinant protein textiles emerge as sustainable alternatives to conventional fibers. Despite their promise, recent evidence suggests that these fibers may pose environmental risks at the end-of-life stage, such as incomplete biodegradation in landfills, microfiber shedding, and chemical leaching from dyes and coatings. The purpose of this study is to examine how these risks are represented through scientific literature, corporate sustainability reports, and policy frameworks, and to identify strategies for integrating risk …
Toward Understanding Multi-Agent Decision Making In Complex Societies, Jonathan Skaggs
Toward Understanding Multi-Agent Decision Making In Complex Societies, Jonathan Skaggs
Theses and Dissertations
This dissertation investigates Multi Agent Decision Making (MADM) within Complex Societies (CS), systems of interdependent agents whose collective behaviors emerge from local interactions. Such emergent dynamics are nonlinear and difficult to predict, posing significant challenges towards understanding how individual decisions scale to societal outcomes. Existing approaches often fall short of capturing the combined attributes of CS, including asymmetry, decentralization, and adaptivity. To address this gap, we introduce new models and analyses of agent strategies that explain how cooperation and stability can arise in CS. Structured around three interrelated projects, this dissertation enhances our comprehension of MADM in CS. The research …
Facility Usage On The International Space Station, Justin St. P. Walsh, Rao Hamza Ali, Ryan Shihabi, Erik Linstead
Facility Usage On The International Space Station, Justin St. P. Walsh, Rao Hamza Ali, Ryan Shihabi, Erik Linstead
Art Faculty Articles and Research
Science experiments on the International Space Station (ISS) and in future space habitats require “facilities,” as they are known to space agencies, as the core building blocks of the research capabilities they provide. Facilities are experimental apparatus that enable research, often (but not always) used for more than one experiment, such as centrifuges, furnaces, gloveboxes, freezers, and more. The US Orbital Segment of the ISS has been home to 191 such facilities, belonging to four of the five ISS international partner agencies as well as private companies, in its 25 years of continuous operation. Until now, there has been no …
Selenium Nanoparticles As Versatile Delivery Tools, Amir Nasrolahi Shirazi, Rajesh Vadlapatla, Ajoy Koomer, Kyle Yep, Keykavous Parang
Selenium Nanoparticles As Versatile Delivery Tools, Amir Nasrolahi Shirazi, Rajesh Vadlapatla, Ajoy Koomer, Kyle Yep, Keykavous Parang
Pharmacy Faculty Articles and Research
Selenium nanoparticles (SeNPs) have emerged as promising metal-based nanoparticles for drug delivery due to their unique physicochemical properties, intrinsic bioactivity, and biocompatibility. SeNPs offer a lower toxicity, higher bioavailability, and flexibility to be customized for surface chemistry compared to traditional selenium compounds. Advances in synthetic strategies, including chemical reduction, green biosynthesis, and surface functionalization with polymers, peptides, or ligands, have improved their stability, targeting capability, and circulation time. SeNP-based systems have demonstrated unique anticancer, antimicrobial, and anti-inflammatory activities, as they can function as drug carriers and active therapeutic agents. The surface of SeNPs has been functionalized with ligands such as …
Decoding The Chameleon Game, Tri Dang '25, Hieu Tran, Brian T. Howard, Sutthirut Charoenphon, Dat Nguyen '25
Decoding The Chameleon Game, Tri Dang '25, Hieu Tran, Brian T. Howard, Sutthirut Charoenphon, Dat Nguyen '25
Student Research
The Chameleon game is a challenging word association activity where players are given a secret word and must respond with words relevant to that secret word. It requires strategic thinking and deduction. The Chameleon must cleverly guess the secret keyword in this game while avoiding suspicion. Our research aims to create an advanced artificial intelligence (AI) model that can play the Chameleon game from both perspectives: as the Chameleon and as a Human. This AI is designed to guess secret keywords based on the information provided by the players, choose the best strategies to avoid detection as the Chameleon, identify …
Unsaturated Fatty Acid Oil-Based Microdroplets: A Promising Novel Class Of Microdroplets, Ramiz S. Alejilat
Unsaturated Fatty Acid Oil-Based Microdroplets: A Promising Novel Class Of Microdroplets, Ramiz S. Alejilat
Seton Hall University Dissertations and Theses (ETDs)
Droplet-based microfluidics has rapidly advanced numerous fields, including chemistry, biology, materials science, medicine, food science, and cosmetics. In these systems, fluorocarbon oil combined with fluorinated surfactants is the preferred medium for fluid encapsulation, offering exceptional stability and biocompatibility essential for sensitive biological and chemical processes. However, growing concerns about the environmental and biological risks associated with fluorinated chemicals have prompted a search for alternatives.
This study is the first to explore the use of unsaturated fatty acids derived from emu oil for microdroplet formation. We characterized droplet formation based on flow rates and the presence non-fluorinated surfactant at a certain …
Computational Molecular Docking Of Fluorinated Morphine Derivatives For Improved Pain Management, Mirabella Romano, Emily Chen
Computational Molecular Docking Of Fluorinated Morphine Derivatives For Improved Pain Management, Mirabella Romano, Emily Chen
Student Scholar Symposium Abstracts and Posters
The opioid epidemic impacts 60 million people worldwide every year. Morphine, a commonly prescribed opioid, binds to the μ-opioid receptor (MOR) in the body via protonation of its tertiary amino group and the MOR. An unfortunate side effect of this binding process is its non-selectivity in both peripheral and central tissues. While activation within inflamed peripheral tissues results in pain relief, activation within central tissues results in the unwanted and addictive side effects of opioids. Because there is a discrepancy in pH between healthy (central) and inflamed (peripheral) tissue, selective binding within the inflamed tissues could provide pain relief without …
Explainable Ai For Liver Transplant Survival Prediction: Integrating Immunological Mismatch Features, Sourab Shaik
Explainable Ai For Liver Transplant Survival Prediction: Integrating Immunological Mismatch Features, Sourab Shaik
Honors Projects
Liver Transplantations are crucial treatment for end-stage liver disease. However, a persistent deficit of donor organs necessitates maximizing the utility of each available graft to minimize failure rates. We evaluated whether donor–recipient molecular immunogenicity metrics - Electrostatic and Hydrophobic Mismatch Scores (HMS/EMS) and eplet-based counts - improve post–liver-transplant survival prediction. The analytic cohort comprised adult, first time, single-organ deceased-donor transplants drawn from Scientific Registry of Transplant Recipients; follow-up was truncated at five years, and the endpoint was all-cause graft failure (earliest of graft failure or death; otherwise, censored). HLA variables were derived via high- resolution conversion and molecular mismatch computations …
Exploring The Potential Of Martian Agriculture: Assessing Viability And Nutritional Composition Of Plants Cultivated In Martian Regolith, Abigail Ross
Honors Theses
In addition to sunlight and water, plants can utilize a small number of nutrients from the soil to biosynthesize all the materials that are needed for growth and development. However, plants require an environment where they are able to obtain those nutrients, such as iron, magnesium, potassium, sulfur, and nitrogen. Environmental factors determine the types and accessibility of nutrients available to plants. Plants then take up these nutrients from the soil to aid in biological mechanisms and the synthesis of important molecules needed for growth and development. Ascorbic acid, commonly known as Vitamin C, is a vital molecule that is …
Lead Sources Detected In Manila's Air After The Phase-Out Of Leaded Gasoline, Grace Betito, Paola Angela Bañaga, Maria Obiminda L. Cambaliza, Melliza Templonuevo Cruz, James Bernard Simpas, Mengli Chen, Jariya Kayee, Armin Sorooshian, Rachel A. Braun, Alexander B. Macdonald
Lead Sources Detected In Manila's Air After The Phase-Out Of Leaded Gasoline, Grace Betito, Paola Angela Bañaga, Maria Obiminda L. Cambaliza, Melliza Templonuevo Cruz, James Bernard Simpas, Mengli Chen, Jariya Kayee, Armin Sorooshian, Rachel A. Braun, Alexander B. Macdonald
Ateneo Atmospheric Physics Laboratory
Abstract
The global phase-out of leaded gasoline marked a major milestone in pollution control, yet modern uses of lead (Pb) continue to pose significant health risks, especially in low- and middle-income countries. In the Philippines, significant data gaps still exist despite increasing exposure. This study presents to the best of our knowledge, the first Pb isotopic fingerprinting of atmospheric aerosols in Metro Manila, Philippines, covering fine (0.56–1 μm) and coarse (5.6–10 μm) fractions, collected in 2018–2019. Results show that local sources, mainly industrial activities (45–62 %) and fossil fuel combustion (30–45 %), are now the dominant contributors to airborne Pb, …
(R2136) Dimensionless Modeling And Analytical Insights Into Botanical Biofiltration Systems For Voc Reduction, N. Jeeva, K. M. Dharmalingam, M. Veeramuni
(R2136) Dimensionless Modeling And Analytical Insights Into Botanical Biofiltration Systems For Voc Reduction, N. Jeeva, K. M. Dharmalingam, M. Veeramuni
Applications and Applied Mathematics: An International Journal (AAM)
This paper investigates the mathematical modeling of volatile organic compound (VOC) removal using a botanical biofiltration system, an effective biological treatment method. It examines mass balance concentrations in the gas and biofilm phases, highlighting their significance in VOC degradation and indoor air quality enhancement. The governing equations of the proposed model are converted into a dimensionless form, resulting in second-order nonlinear differential equations. Derived from mass transfer and reaction kinetics principles, these equations incorporate specific boundary conditions to capture gas-biofilm interactions and VOC removal dynamics in biofiltration. The modified Adomian decomposition method (MADM) is utilized to derive analytical solutions for …
Generating Predictive Gene Expression Signatures For Alzheimer's Disease Using Postmortem Brain Tissue, Ashley Duche
Generating Predictive Gene Expression Signatures For Alzheimer's Disease Using Postmortem Brain Tissue, Ashley Duche
Pharmaceutical Sciences (PhD) Dissertations
Background: Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid-beta (Aβ) plaques and tau protein aggregates. These pathological features develop in specific brain regions, but why some areas are more vulnerable to early AD-related changes remains unclear. To address this, predictive gene expression signatures were developed to explore the molecular mechanisms underlying regional susceptibility to AD pathology.
Methods: This was performed using postmortem brain (PMB) tissue from participants in the Religious Orders Study and Memory and Aging Project (ROSMAP), Mayo Clinic, and Mount Sinai Brain Bank (MSBB) to generate gene expression signatures from six brain …
Large Language Models As Machines Of Beauty: Cognitive Averaging, Latent Space Geometry, And The Entropic Foundations Of Aesthetic Preference, Daniel Plate, James Hutson
Large Language Models As Machines Of Beauty: Cognitive Averaging, Latent Space Geometry, And The Entropic Foundations Of Aesthetic Preference, Daniel Plate, James Hutson
Faculty Scholarship
This study advances the position that large language models (LLMs) and human perceptual systems are governed by a shared computational drive toward prototypicality, entropy reduction, and aesthetic coherence. Drawing on developmental evidence that infants exhibit early preferences for facial symmetry and averageness, the analysis situates aesthetic preference within broader research on processing fluency and predictive coding, emphasizing that biological perception rewards stimuli that reduce uncertainty and support efficient information compression. This foundation is used to examine how LLMs, through cross-entropy optimization, perplexity minimization, and latent space clustering, converge on high-density representational regions that operate as statistical prototypes of linguistic and …