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Carbon Nanomaterials In Biological Systems, Sijie Lin Aug 2007

Carbon Nanomaterials In Biological Systems, Sijie Lin

All Theses

ABSTRACT


This thesis intends to present, from the biophysical viewpoint, my study on understanding carbon nanomaterials in biological and environmental systems. Carbon nanotubes and fullerenes represent a major family of carbon nanoparticles which possess distinct electrical, optical and mechanical properties. However, the major hurdle for making carbon nanomaterials bioavailable lies in their tendency toward bundling, driven by hydrophobic interaction, van der Waals force, and pi-stacking. To overcome this problem, we used non-covalent binding of zwitterionic lysophopholipids (LPL) onto the external surfaces of single-walled carbon nanotubes (SWNTs). This method affords superior SWNT solubility in aqueous solution. The stability of SWNT-LPL complex …


Research On Establishment Of Oil Spill Emergency Response System In China Qingdao Port Based On Ann, Ge Zhang Aug 2007

Research On Establishment Of Oil Spill Emergency Response System In China Qingdao Port Based On Ann, Ge Zhang

World Maritime University Dissertations

No abstract provided.


Probabilistic Bioenergetic/Toxicity Modeling Approach For Estimating Toxicant Induced Mortality To Target Invasive Species And Non-Target Wildlife, John Johnston, Randal S. Stahl, H. Jeffrey Homan, George M. Linz, Will C. Pitt Aug 2007

Probabilistic Bioenergetic/Toxicity Modeling Approach For Estimating Toxicant Induced Mortality To Target Invasive Species And Non-Target Wildlife, John Johnston, Randal S. Stahl, H. Jeffrey Homan, George M. Linz, Will C. Pitt

Managing Vertebrate Invasive Species

Non-target species may be exposed to rodenticides via feeding on rodenticide baits or the carcasses of poisoned target species. As invasive species frequently negatively impact threatened or endangered (T and E) species, there is frequently spatial and temporal overlap of invasive species and T and E species. Risk assessments provide a means to estimate the probability of rodenticide associated adverse effects to non-target species (including T and E species). Quantification of risk provides critical information for decision-makers to weigh the benefits and risks of proposed rodenticide uses and to compare the risks of management with risks associated with no management …


Research And Development Of A New Rodenticide For Nutria, Jeff J. Mach, Richard M. Poche Aug 2007

Research And Development Of A New Rodenticide For Nutria, Jeff J. Mach, Richard M. Poche

Managing Vertebrate Invasive Species

The nutria (Myocastor coypus) is a large semi-aquatic rodent, declared as one of the 100 worst invasive species in the world by the IUCN Invasive Species Specialist Group in 2000. Through USDA Small Business Innovative Research Phase I (Mach 2004) and Phase II (Mach 2006) funding, Genesis is developing a new nutria rodenticide as an alternative to the currently-registered zinc phosphide bait. Our course of research and development is described herein: live-trapping, laboratory non-toxic choice studies, laboratory toxicity bioassays, and field toxicity studies. Two active ingredients and two bait types proved to be successful, however, only cholecalciferol in …


Genetic Options For The Control Of Invasive Vertebrate Pests: Prospects And Constraints, Ronald E. Thresher Aug 2007

Genetic Options For The Control Of Invasive Vertebrate Pests: Prospects And Constraints, Ronald E. Thresher

Managing Vertebrate Invasive Species

Conventional methods for the control of invasive pests are generally effective only on small-space scales or short-time frames. For most well established pest populations, longer-term efforts to manage the problem have been largely abandoned. I examine the potential of using “autocidal” genetic techniques to control terrestrial vertebrate pests, based on the inheritance through males of transgenes that either sterilize females or convert them into functional males (“daughterless”). Simulation analysis of two high profile pest species, the cane toad (Bufo marinus) in Australia and brown rats (Rattus norvegicus) in an urban environment, using realistic parameters, suggests that …


Interview With Roger Allen Konka, Springwater Farm, 2007 (Audio), Roger Allen Konka Jul 2007

Interview With Roger Allen Konka, Springwater Farm, 2007 (Audio), Roger Allen Konka

All Sustainability History Project Oral Histories

Interview of Roger Allen Konka by Michael Schott on July 29th, 2007.

The interview index is available for download.


Relaxin As A Diagnostic Tool For Pregnancy In The Coyote (Canis Latrans), Debra A. Carlson, Eric M. Gese Jul 2007

Relaxin As A Diagnostic Tool For Pregnancy In The Coyote (Canis Latrans), Debra A. Carlson, Eric M. Gese

United States Department of Agriculture Wildlife Services: Staff Publications

The diagnosis of pregnancy in the domestic dog (Canis familiaris) often employs specialized equipment, experienced staff, and the cooperation of the bitch. These procedures can be challenging when the subject is a wild canid, particularly in a field setting. In addition, reproductive hormone assays are unreliable as a diagnostic tool because the estrous profiles of pregnant and pseudopregnant canines are similar. However, research has demonstrated that the hormone relaxin can be detected in maternal blood after embryonic implantation, but remains negligible in non-pregnant females. We investigated the use of relaxin as a diagnostic marker of pregnancy in the …


Sheep Updates 2007 - Part 1, Richard Gunner, Anthony Clarke, Kevin Bell, Hugh Dove, H. M. Burrow, Kevin Goss Jul 2007

Sheep Updates 2007 - Part 1, Richard Gunner, Anthony Clarke, Kevin Bell, Hugh Dove, H. M. Burrow, Kevin Goss

Sheep Updates

This session covers six papers from different authors:

PLENARY

1. Life beyond the farmgate - the meat perspective, Richard Gunner – Principal:- Richard Gunner’s Fine Meats

2. Do you need to worry about climate change?, Anthony Clark, Centre for Resource and Environmental Studies, Australian National University and Bureau of Rural Sciences.

3. Ruminant nutrition panel session - The impact of nutrition on animal health and welfare, Kevin Bell, School of Veterinary and Biomedical Studies, Murdoch University

4. Ruminant nutrition panel session - Pasture/animal interactions, Hugh Dove, Chief Research Scientist, CSIRO Plant Industry

5. Precision Cattle Breeding for …


Sheep Updates 2007 - Part 4, Dean Thomas, Dominique Blache, Dean Revell, Hayley Norman, Phil Vercoe, Zoey Durmic, Serina Digby, Di Mayberry, Megan Chadwick, Martin Sillence, David Masters, R. Silberstein, F. Byrne, P. G. H. Nichols, J. Young, L. Aitkins, M. G. Wilmot, A. J. Rintoul, T. Lambert, D. R. Mcclements, P. Raper, P. Ward, C. Walton, T. York, David Pethick, David Hopkins, Malcolm Mcphee, D. B. Savage, J. V. Nolan, I. R. Godwin, A. Aoetpah, T. Nguyen, N. Baillie, C. Lawler, Ken Geenty, John Smith, Darryl Smith, Tim Dyall, Grant Uphill, John Young, Michael Paton, John Dorrian Jul 2007

Sheep Updates 2007 - Part 4, Dean Thomas, Dominique Blache, Dean Revell, Hayley Norman, Phil Vercoe, Zoey Durmic, Serina Digby, Di Mayberry, Megan Chadwick, Martin Sillence, David Masters, R. Silberstein, F. Byrne, P. G. H. Nichols, J. Young, L. Aitkins, M. G. Wilmot, A. J. Rintoul, T. Lambert, D. R. Mcclements, P. Raper, P. Ward, C. Walton, T. York, David Pethick, David Hopkins, Malcolm Mcphee, D. B. Savage, J. V. Nolan, I. R. Godwin, A. Aoetpah, T. Nguyen, N. Baillie, C. Lawler, Ken Geenty, John Smith, Darryl Smith, Tim Dyall, Grant Uphill, John Young, Michael Paton, John Dorrian

Sheep Updates

This session covers eight papers from different authors:

GRAZING

1. The impact of high dietary salt and its implications for the management of livestock grazing saline land, Dean Thomas, Dominique Blache, Dean Revell, Hayley Norman, Phil Vercoe, Zoey Durmic, Serina Digby, Di Mayberry, Megan Chadwick, Martin Sillence and David Masters, CRC for Plant-based Management of Dryland Salinity, Faculty of Natural & Agricultural Sciences, The University of Western Australia, WA.

2. Sustainable Grazing on Saline Lands - outcomes from the WA1 research project, H.C. Norman1,2, D.G. Masters1,2, R. Silberstein1,2, F. Byrne2,3, P.G.H. Nichols …


Methyl Esterification Of Fatty Acids And Eicosanoids With A Novel Reagent Trimethylsilyldiazomethane For Analysis By Gas Chromatography-Mass Spectrometry, Aditi Munmun Sengupta Jul 2007

Methyl Esterification Of Fatty Acids And Eicosanoids With A Novel Reagent Trimethylsilyldiazomethane For Analysis By Gas Chromatography-Mass Spectrometry, Aditi Munmun Sengupta

Master's Theses and Doctoral Dissertations

Fatty acids are compounds with limited water solubility that belong to the lipid class of bio-organic compounds and can be utilized as a source of energy by the body or as precursors to oxidized compounds that have roles in inflammation and in the regulation of vascular tone. The prostaglandins are naturally occurring 20-carbon cyclopentano fatty acid derivatives produced in mammalian tissue from polyunsaturated fatty acids (PUFAs) and are generated from endoperoxide precursors of arachidonic acid and related polyunsaturated fatty acids by the enzyme cyclo-oxygenase (COX). The lipoxygenase (LOX) enzymes convert arachidonic acid into hydroperoxy derivatives of PUFAs termed leukotrienes, which …


The Future Of Unl Energy Sciences Jul 2007

The Future Of Unl Energy Sciences

Nebraska Center for Energy Sciences Research: White Papers and Presentations

UNL has a large number of faculty conducting research on energy-related topics. However, strategic coordination needs improvement, and there are significant opportunities to leverage synergies across departments and colleges, centers, and institutes. In addition, there are critical gaps in expertise that need filling to achieve critical mass and national prominence in key areas.

This white paper seeks to identify a set of thematic areas that would help focus UNL faculty resources on emerging opportunities in the energy-related sciences and serve as a framework to achieve the following goals:

♦ Develop innovative research programs that enhance renewable energy resources and energy …


Scwds Briefs: Volume 23, Number 2 (July 2007), Gary L. Doster , Editor, Scwds Briefs, Michael J. Yabsley Jul 2007

Scwds Briefs: Volume 23, Number 2 (July 2007), Gary L. Doster , Editor, Scwds Briefs, Michael J. Yabsley

Southeastern Cooperative Wildlife Disease Study: Publications

Table of Contents:

SCWDS History Continued: The CapChur Gun

SCWDS Honored

More Interesting HD Events from 2006

Fever Ticks

Ehrlichia in White-tailed Deer

Meningeal Worms in Sika Deer

The Devils’ Disease

Recent SCWDS Publications Available


Quality Of Weight Loss Advice On Internet Forums, Kevin O Hwang, Kiran Farheen, Craig W Johnson, Eric J Thomas, Ann S Barnes, Elmer V Bernstam Jul 2007

Quality Of Weight Loss Advice On Internet Forums, Kevin O Hwang, Kiran Farheen, Craig W Johnson, Eric J Thomas, Ann S Barnes, Elmer V Bernstam

Faculty, Staff and Student Publications

BACKGROUND: Adults use the Internet for weight loss information, sometimes by participating in discussion forums. Our purpose was to analyze the quality of advice exchanged on these forums. METHODS: This was a retrospective analysis of messages posted to 18 Internet weight loss forums during 1 month in 2006. Advice was evaluated for congruence with clinical guidelines; potential for causing harm; and subsequent correction when it was contradictory to guidelines (erroneous) or potentially harmful. Message- and forum-specific characteristics were evaluated as predictors of advice quality and self-correction. RESULTS: Of 3368 initial messages, 266 (7.9%) were requests for advice. Of 654 provisions …


Climate. Stern Review: The Economics Of Climate Change, Nicholas Stern Jul 2007

Climate. Stern Review: The Economics Of Climate Change, Nicholas Stern

New England Journal of Public Policy

This chapter examines the increasingly serious impacts on people as the world warms. Climate change is a serious and urgent issue. The Earth has already warmed by 0.7°C since around 1900 and is committed to further warming over coming decades simply due to past emissions. On current trends, average global temperatures could rise by 2–3°C within the next fifty years or so, with several degrees more in the pipeline by the end of the century if emissions continue to grow. This chapter examines how the physical changes in climate . . . affect the essential components of lives and livelihoods …


The Introduction And Emergence Of Wildlife Diseases In North America, Robert G. Mclean Jun 2007

The Introduction And Emergence Of Wildlife Diseases In North America, Robert G. Mclean

United States Department of Agriculture Wildlife Services: Staff Publications

Contents:

Specific Invasive and Emerging Wildlife Diseases: West Nile Virus, Hantavirus, Lyme Disease, Monkeypox, Raccoon Rabies
Foreign Wildlife Diseases That Could Invade the United States: Highly Pathogenic Avian Influenza, Rift Valley Fever, Nipah Virus, Japanese Encephalitis
Prevention, Detection, and Control of Invading and Emerging Diseases
References


Coyotes As Sentinels For Monitoring Bovine Tuberculosis Prevalence In White-Tailed Deer, Todd C. Atwood, Kurt C. Vercauteren, Thomas J. Deliberto, Holly J. Smith, Justin S. Stevenson Jun 2007

Coyotes As Sentinels For Monitoring Bovine Tuberculosis Prevalence In White-Tailed Deer, Todd C. Atwood, Kurt C. Vercauteren, Thomas J. Deliberto, Holly J. Smith, Justin S. Stevenson

United States Department of Agriculture Wildlife Services: Staff Publications

Mycobacterium bovis, the causative agent of bovine tuberculosis (bTB), is endemic in free-ranging white-tailed deer (Odocoileus virginianus) in 5 counties (Alcona, Alpena, Montmorency, Oscoda, and Presque Isle) in the northeastern Lower Peninsula of Michigan, USA. The presence of a wildlife reservoir of tuberculosis in Michigan and the incidence of bTB in cattle (Bos taurus) resulted in Michigan losing its bTB accredited-free status. Subsequent wildlife surveillance programs identified relatively high disease prevalence in coyotes (Canis latrans), generating interest in their potential to serve as a sentinel species to detect bTB prevalence in white-tailed deer. …


Cameras, Coyotes, And The Assumption Of Equal Detectability, Eveline Se Quin Larrucea, Peter F. Brussard, Michael M. Jaegar, Reginald H. Barrett Jun 2007

Cameras, Coyotes, And The Assumption Of Equal Detectability, Eveline Se Quin Larrucea, Peter F. Brussard, Michael M. Jaegar, Reginald H. Barrett

United States Department of Agriculture Wildlife Services: Staff Publications

Remote cameras are an increasingly important tool in management and wildlife studies. However, we often do not know if they provide an unbiased sample of populations. Using a marked, radio-collared population of coyotes (Canis latrans) of known social status, we evaluated the influence of temporal (daily and seasonal) and spatial (distance between units, habitat, and proximity to human structures) factors on vulnerability to photo-captures. During 8 unbaited camera sessions of 6 weeks each, we obtained 158 coyote photographs at a photo-capture success rate of 1.6%. We were able to identify not only marked individuals, but also a number …


Responses To Weight Loss Treatment Among Obese Individuals With And Without Bed: A Matched-Study Meta-Analysis, Bruce E. Blaine, J. Rodman Jun 2007

Responses To Weight Loss Treatment Among Obese Individuals With And Without Bed: A Matched-Study Meta-Analysis, Bruce E. Blaine, J. Rodman

Statistics Faculty/Staff Publications

The moderating influence of binge eating status on obese individuals’ responses to weight loss treatment was evaluated with a meta-analysis of 36 tests of weight loss treatment (n=792) that were matched to control key background variables. After controlling for pre-treatment weight, treatment produced more weight loss in samples of obese non- BED compared with obese BED participants. Weight loss treatment produced large posttreatment reductions in depression in both obese BED and non-BED samples. The results indicate that BED status moderated post-treatment weight loss among people in weight treatment programs. Obese BED (average weight loss= 1.3 kg) samples lost negligible weight …


Tumbleweed Exploratory Drilling Environmental Assessment, United States Deparment Of The Interior, Bureau Of Land Management Jun 2007

Tumbleweed Exploratory Drilling Environmental Assessment, United States Deparment Of The Interior, Bureau Of Land Management

All U.S. Government Documents (Utah Regional Depository)

This Environmental Assessment (EA) has been prepared to analyze Stewart Petroleum Corporation’s (Stewart) proposed exploratory natural gas drilling on their Federal leases within the Tumbleweed Oil and Gas Unit (Tumbleweed Unit). This EA is a site-specific analysis of potential impacts that could result with the implementation of Alternative - the Proposed Action; Alternative B – Buried Pipelines; or Alternative C - the No Action Alternative. The EA assists the Bureau of Land Management (BLM) in project planning and ensuring compliance with the National Environmental Policy Act (NEPA), and in making a determination as to whether any “significant” impacts could result …


Status Of Blue Whales Off Isla De Chiloe, Chile, During 2007 Field Season, Bárbara Galletti Vernazzani, Carole A. Carlson, Elsa Cabrera, Robert L. Brownell Jr. Jun 2007

Status Of Blue Whales Off Isla De Chiloe, Chile, During 2007 Field Season, Bárbara Galletti Vernazzani, Carole A. Carlson, Elsa Cabrera, Robert L. Brownell Jr.

United States Department of Commerce: Staff Publications

Since 2004, a collaborative research program of the Alfaguara Project on blue whales off Isla de Chiloe, Chile, has produce important new information on present day conservation status of this population. This paper presents preliminary findings from 2007 and compares such data with that reported in previous years. Land-based monitoring in 2007 resulted in 36 days of observations with 262.85 h of land-based effort. The maximum number of individuals sighted from land ranged from 2 to 44, with an average of 18.14 individuals per day (SD=12.00 ; CI95% =14.08 - 22.20). Preliminary results on fifteen of seventeen photo-identification surveys conducted …


Regulation Of Cell Diameter, For3p Localization, And Cell Symmetry By Fission Yeast Rho-Gap Rga4p, Maitreyi Das, David J. Wiley, Saskia Medina, Helen A. Vincent, Michelle D. Larrea, Andrea Oriolo, Fulvia Verde Jun 2007

Regulation Of Cell Diameter, For3p Localization, And Cell Symmetry By Fission Yeast Rho-Gap Rga4p, Maitreyi Das, David J. Wiley, Saskia Medina, Helen A. Vincent, Michelle D. Larrea, Andrea Oriolo, Fulvia Verde

Chemistry and Physics Faculty Articles

Control of cellular dimensions and cell symmetry are critical for development and differentiation. Here we provide evidence that the putative Rho-GAP Rga4p of Schizosaccharomyces pombe controls cellular dimensions. rga4Δ cells are wider in diameter and shorter in length, whereas Rga4p overexpression leads to reduced diameter of the growing cell tip. Consistent with a negative role in cell growth control, Rga4p protein localizes to the cell sides in a “corset” pattern, and to the nongrowing cell tips. Additionally, rga4Δ cells show an altered growth pattern similar to that observed in mutants of the formin homology protein For3p. Consistent with …


Optimal Foraging In Eastern Fox Squirrel: Food Size Matters For A Generalist Forager, Robert Tatina Jun 2007

Optimal Foraging In Eastern Fox Squirrel: Food Size Matters For A Generalist Forager, Robert Tatina

The Prairie Naturalist

Classical optimal foraging theory (OFT) predicts that an animal forages optimally when it chooses foods with the highest energy benefit or minimizes time searching for and handling food. r evaluated OFT by presenting eastern fox squirrel (Sciurus niger) multiple food items (i.e., sunflower seeds and • fruits) in various density combinations. When the choice was between foods of equal energy benefits but different costs, they chose forage items with greater costs, seemingly not foraging optimally. However, individuals showed a partial preference for food items which minimized search time, but not handling time. The eastern fox squirrel also was …


Mountain Beaver: A Primitive Fossorial Rodent, Wendy M. Arjo May 2007

Mountain Beaver: A Primitive Fossorial Rodent, Wendy M. Arjo

United States Department of Agriculture Wildlife Services: Staff Publications

As the largest mammalian order, rodents are nearly cosmopolitan in distribution, can exploit a broad spectrum of foods, and can often reach high population densities. One sole representative of the most primitive family of rodents, Aplodontidae, does not share some of these common rodent characteristics. The aplodontoid rodents in the family Aplodontidae and Mylagsulidae radiated during the Miocene from the Allomyinae family (Carraway and Verts 1993). The extinct Mylagaulidae represents the earlier radiation of these rodents who exhibited great specialization (Carraway and Verts 1993). Unlike the other members of the rodent order, mountain beavers are not prolific breeders; nor are …


Estimation Of Risk For Developing Cardiac Problem In Patients Of Type 2 Diabetes As Obtained By The Technique Of Density Estimation, Ajit Mukherjee, Ajit Mathur, Rakesh Mittal May 2007

Estimation Of Risk For Developing Cardiac Problem In Patients Of Type 2 Diabetes As Obtained By The Technique Of Density Estimation, Ajit Mukherjee, Ajit Mathur, Rakesh Mittal

Journal of Modern Applied Statistical Methods

High levels of cholesterol and triglyceride are known to be strongly associated with development of cardiac problem in patients of type 2 diabetes. In a hospital-based study, patients showing ECG positive were compared with those who were not. The observations on cholesterol and triglyceride were considered for estimation of risk for developing the cardiac problem. The technique of density estimation employing Epanechnikov kernel was used for estimating bivariate probability density functions with respect to observations on cholesterol and triglyceride of the two groups. Using the odds form of Bayes’ rule, the estimates of posterior odds were computed.


Analysis Of Nutraceuticals For Toxic Metals: Development And Validation Of Sample Preparation Method, Julia Cooper May 2007

Analysis Of Nutraceuticals For Toxic Metals: Development And Validation Of Sample Preparation Method, Julia Cooper

All Theses

With increasing numbers of health-conscious consumers purchasing nutraceutical supplements, total sales in the nutrition industry have soared to over $200 billion in 2006. It is important to assess the safety of these nutraceutical products, with specific regards to toxic metals, including arsenic, cadmium, lead, and mercury. Because species of these metals may be more toxic than others, they can have hazardous health effects if ingested in excess quantities. The work described in this thesis focuses on the development of a sample preparation method for nutraceutical products, specifically ethanolic tinctures and glycerin-based matrices, and analysis of these products by inductively coupled …


The Sensitivity Of The Southwest Monsoon Phytoplankton Bloom To Variations In Aeolian Iron Deposition Over The Arabian Sea, Jerry D. Wiggert, Raghu G. Murtugudde May 2007

The Sensitivity Of The Southwest Monsoon Phytoplankton Bloom To Variations In Aeolian Iron Deposition Over The Arabian Sea, Jerry D. Wiggert, Raghu G. Murtugudde

CCPO Publications

[1] A coupled, 3-D biophysical ocean general circulation model is used to investigate how aeolian iron deposition affects the Arabian Sea ecosystem. Two separate aeolian iron deposition fields, derived from the GISS and GOCART atmospheric transport models, have been applied as surface boundary conditions. The model results exhibit widespread biogeochemical sensitivity to the choice of deposition field. With GOCART deposition, SW Monsoon phytoplankton blooms in the western and central Arabian Sea are enhanced and exhibit greater realism. The central Arabian Sea bloom is supported by supplemental input of horizontally advected iron from a pool that undergoes a yearlong progression that …


Functionalized Nanomaterials: Synthesis, Characterization, And Applications, Liangwei Qu May 2007

Functionalized Nanomaterials: Synthesis, Characterization, And Applications, Liangwei Qu

All Dissertations

Due to their unique electronic, optical, catalytic and mechanical properties, nanomaterials (nanoparticles and nanotubes) have been attracting much attention over the past decades. In this dissertation, polymeric nanoparticles bearing derivatized D-mannose and galactose molecules were prepared via dispersion polymerization and their interactions with various bacterial cells were studied. The results show that there are strong adhesin-specific interactions of the nanoparticles with E. coli cells, resulting significant nanoparticles-madiated cell agglutination.
Poly(ethylene glycol)-coated magnetic polymer nanoparticles were synthesized through miniemulsion polymerization by using macromonomer as both a comonomer and a surfactant. The resulting magnetic polymer nanoparticles were successfully used for bio-detection and …


Extraction Method Development And In Vivo And In Vitro Toxicity Studies Of The Etiologic Agent Of Avian Vacuolar Myelinopathy, Faith Wiley May 2007

Extraction Method Development And In Vivo And In Vitro Toxicity Studies Of The Etiologic Agent Of Avian Vacuolar Myelinopathy, Faith Wiley

All Dissertations

Avian vacuolar myelinopathy (AVM) is a neurological disease affecting birds in the southeastern United States. The cause of the disease has not yet been determined but is believed to be a naturally produced toxin and is associated with aquatic vegetation. Current research on AVM is limited to in vivo studies utilizing whole tissue or vegetative samples. The objectives of this research were to develop extraction methods for isolating the putative AVM toxin from vegetative samples and to develop an in vitro bioassay for detection and study of the toxin. Samples of vegetation were collected from reservoirs known to be affected …


Object-Relational Mapping As A Persistence Mechanism For Object-Oriented Applications, Jeffrey M. Barnes Apr 2007

Object-Relational Mapping As A Persistence Mechanism For Object-Oriented Applications, Jeffrey M. Barnes

Mathematics, Statistics, and Computer Science Honors Projects

Many object-oriented applications created today, especially Web applications, use relational databases for persistence. Often there is a straightforward correspondence between database tables on the one hand and application classes on the other. Application developers usually write a great deal of code to connect to and query the database, code which differs little from class to class and is often tedious to write. Moreover, the parallel class and table structures constitute a duplication of information, which requires duplication of work and increases the likelihood of errors. Ideally, we could automate this duplication, rendering it invisible to developers. This is the idea …


Biomarker Evaluation Using The Controls As A Reference Population, Ying Huang, Margaret Pepe Apr 2007

Biomarker Evaluation Using The Controls As A Reference Population, Ying Huang, Margaret Pepe

UW Biostatistics Working Paper Series

The classification accuracy of a continuous marker is typically evaluated with the Receiver Operating Characteristic Curve. In this paper, we study an alternative conceptual framework, the "percentile value". In particular the controls only provide a reference distribution to standardize the marker. The analysis proceeds by analyzing the standardized marker only in cases. The approach is shown to be equivalent to ROC analysis. Advantages are that it provides a framework more familiar to biostatisticians and it opens up avenues for new statistical techniques in biomarker evaluation. We develop several new procedures based on this framework for comparing biomarkers and for comparing …