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Biopsychosocial Resilience Through A Complex Adaptive Systems Lens: A Narrative Review Of Nonlinear Modeling Approaches, Adam W. Kiefer, David Pincus

Psychology Faculty Articles and Research

Human resilience is often considered as static traits using a reductionist approach. More recent work has demonstrated it to be a dynamic and emergent property of complex systems. This narrative review explores human resilience through a self-organizing framework with a specific emphasis on the application of nonlinear modeling approaches. Four classes of approaches are examined: univariate dynamics, bivariate coupling, topological modeling, and network modeling. Univariate dynamics capture the temporal structure and flexibility within a single time series, while bivariate coupling approaches quantify the interaction dynamics and coordination between two time series. Topological modeling identifies bifurcations and attractor dynamics as signals …

Revised Draft Final Quarterly Operations And Maintenance Report Butte Treatment Lagoon System – First Quarter 2022, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Antimicrobial Polymers And Small Molecules From Multicyclic Compounds And Engineering Of Sustainable Polymers, Leman Buzoglu Kurnaz

Theses and Dissertations

In this dissertation, the synthesis of polymers and small molecules from multicyclic compounds and the development of sustainable polymers from renewable feedstock were investigated. The antimicrobial biomaterials and sustainable polymers were characterized and their properties were discussed. In Chapter 1, the overall background and recent developments of antimicrobial biomaterials and their application were discussed. Later, sustainable polymers from renewable biomass and their synthesis methods were given. Afterward, the main research objectives of this doctoral research study were described. In Chapter 2, the synthesis of multiple charged small molecules from multicyclic compounds was discussed. These compounds were obtained by using various …

Design And Synthesis Of N-Succinyl-L,L-2.6-Diaminopimelic Acid Desuccinylase Inhibitors As Potential Novel Antibiotics, Thomas Dipuma

Master's Theses

N-Succinyl-L,L-2,6-Diaminopimelic Acid Desuccinylase (DapE) is a bacterial enzyme located in the lysine biosynthetic pathway of all Gram-negative and most Gram-positive species of bacteria including the notorious ESKAPE pathogens, or pathogenic strains of bacteria that have developed significant levels of resistance to currently available antibiotics. As a means to combat this challenge of growing antimicrobial resistance, we have identified the bacterial enzyme DapE as a conserved, novel enzymate target within these resistant bacterial strains,as DapE is responsible for the production of m-DAP and lysine which are ultimately employed in bacterial cell wall synthesis. The overall aim of this research is to …

Poor Water Quality Persists In Diverse Urban Communities, Rae Cade, Danlin Yu, Kyle Whyte, Pankaj Lal, Cortni Borgerson

Department of Earth and Environmental Studies Faculty Scholarship and Creative Works

While humans need water to survive, water can also efficiently transmit microbial diseases and heavy metals to consumers. Over 50,000 water violations occurred in 2020 and such burdens were not borne equally amongst consumers. Yet, the factors that drive such variation remain unclear. We examined the interactions between water quality and inherited equity gaps in one of the most diverse urban areas in the United States. We used publicly available drinking water datasets to determine which contaminant was most prevalent between 2010–2020 and who was significantly more likely to be affected by this contamination. We found that a lack of …

A Review On Antibacterial Activity Of Nanoparticles, Badr-Edine Sadoq, Mohammed Reda Britel, Adel Bouajaj, Ramzi Maâlej, Ahmed Touhami, Marwa Abid, Hanen Douiri, Fakhita Touhami, Amal Maurady

Physics & Astronomy Faculty Publications

The increasing resistance of bacteria to antibiotic agents is a main global public health problem. The use of nanoparticles is one of the promising ways to overcome microbial resistance to antimicrobial agents. Metal nanoparticles are increasingly used to target bacterial strains. Advances in nanotechnology, in particular the ability to synthesize nanoparticles of specific size and shape, are likely to lead to the development of new antibacterial agents. The antibacterial activities of nanoparticles are largely influenced by their sizes and large surface area/mass ratio. The antibacterial mechanisms of nanoparticles are poorly understood, but the currently accepted mechanisms include oxidative stress induction, …

Dental Hygiene Students Reported Physiological Symptoms Associated With Wearing An N95 Respirator Mask, Peyton Shea Butler

Dental Hygiene Theses & Dissertations

Purpose: Physiological symptoms and comfort levels while wearing an N95 respiratory mask has not been examined with dental hygienists. The purpose of this study was to investigate dental hygiene students reported physiological symptoms and comfort perception while wearing an N95 respirator mask during patient care appointments. Methods: After IRB approval (IRB #1987754-2), a 16-item questionnaire was distributed through email to a convenience sample of 65 dental hygiene students. Questions assessed respiratory, dermatologic, cardiac, mask mouth and general physiological symptoms, as well as comfort levels. Additionally, participants were asked to respond to demographic questions and one open ended question inquiring about …

Self-Organization For Community Resilience In An Invisible Agricultural Community, Anna Erwin, Chelsea A. Silva, Zhao Ma

School of Earth, Environmental, & Marine Sciences Faculty Publications

This study investigates how self-organizing efforts by residents of informal settlements, primarily migrant and informal farmworkers, shape community resilience in Majes, a water-scarce irrigation district in the Atacama Desert of Peru. We collected 45 semi-structured interviews with residents and authorities in Majes and analyzed findings through a framework of self-organizing. Analyses revealed that self-organizing by residents of informal settlements incorporated the three components of White’s theory of Community Agency and Community Resilience, which contends that marginalized communities increase resilience by fostering a commons praxis, practicing a prefigurative politics, and developing opportunities for economic autonomy. We also found …

Case Study And Recommendations On Technological Collaboration In Supporting Development Of Qinghai-Tibet Plateau Under The Belt And Road Initiative, Xiaowei Nie, Xiaoduo Pan, Zhuoying Zhang, Yang Yang, Yang Yang, Xinyu Gong

Bulletin of Chinese Academy of Sciences (Chinese Version)

The Belt and Road Initiative has played an important role in promoting the construction of a community with a shared future for mankind and actively integrated into the global governance system over the past decade. At the same time, through scientific and technological cooperation, it has also significantly impacted domestic regional development. The Tibetan Plateau, known as the “Third Pole” of the Earth, is not only an important internationalized region but also a crucial component of the Belt and Road Initiative, offering opportunities to establish a South Asian land corridor. This study analyzes and summarizes the role of scientific and …

Main Climate Change Characteristics And Disaster Risks Oriented Towards Carbon Neutrality Over The Belt And Road Regions, Jingyong Zhang, Jing He, Lixia Zhang, Zhencai Du, Renqiang Li, Ming Xu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Climate change has been widely recognized as one of most severe risks that the world faces. The recent 50 years are the warmest period in the last 2 000 years with respect to surface temperature averaged over the Belt and Road regions, which is mainly attributed to continuously increasing and accumulating of carbon emissions from human activities. Since the 1980s, over the Belt and Road regions mean climate change is characterized as surface warming at a faster rate, increased precipitation and evaporation, and accelerated sea level rise among others, and extreme weather and climate events such as hot extremes, rainstorms …

Accelerating Construction Of New Development Pattern Of Dual Circulation By Building Belt And Road With High Quality, Xiong Ying, Zijian Shangguan, Ying Liu

Bulletin of Chinese Academy of Sciences (Chinese Version)

This paper firstly reviews the achievements of the Belt and Road Initiative (BRI) since its raise 10 years ago in terms of policy communication, facility connectivity, trade exchanges, financial integration, and people-to-people bond, and explains the significance of BRI to the new development pattern of the dual circulation. Then, combined with the actual national conditions of China's new development stage, it analyzes the opportunities and challenges of the construction of the Belt and Road in the new situation of the global economy and trade. Finally, it puts forward policy suggestions for the high-quality construction of the Belt and Road in …

Building The Health Silk Road Within The Belt And Road Initiative From A Systematic View, Shouyang Wang, Qin Bao, Qi Zhang

Bulletin of Chinese Academy of Sciences (Chinese Version)

Life and health are common challenges faced by mankind, and the building of the Health Silk Road is the fundamental content of the high-quality development of the Belt and Road Initiative. There are great differences in the level of economic and social development of the countries and regions along the Belt and Road. Under the increasingly complex and severe global biosecurity situation, scientific guidance from a systematic perspective is required for comprehensively improving the medical and health conditions and life and health quality of different countries and regions. Aiming at the challenges faced by the building of the Health Silk …

History And Current Status Of Mediterranean Spotted Fever (Msf) In The Crimean Peninsula And Neighboring Regions Along The Black Sea Coast, Muniver T. Gafarova, Marina E. Eremeeva

Biostatistics, Epidemiology & Environmental Health Sciences: Faculty Publications

Mediterranean spotted fever (MSF) is a tick-borne rickettsiosis caused by Rickettsia conorii subspecies conorii and transmitted to humans by Rhipicephalus sanguineus ticks. The disease was first discovered in Tunisia in 1910 and was subsequently reported from other Mediterranean countries. The first cases of MSF in the former Soviet Union were detected in 1936 on the Crimean Peninsula. This review summarizes the historic information and main features of MSF in that region and contemporary surveillance and control efforts for this rickettsiosis. Current data pertinent to the epidemiology of the disease, circulation of the ticks and distribution of animal hosts are discussed …

The Public Health Impact Of Paxlovid Covid-19 Treatment In The United States, Yuan Bai, Zhanwei Du, Lin Wang, Eric H. Y. Lau, Isaac Fung, Petter Holme, Ben Cowling, Alison Galvani, Robert Krug, Lauren Ancel Meyers

Biostatistics, Epidemiology & Environmental Health Sciences: Faculty Publications

The antiviral drug Paxlovid has been shown to rapidly reduce viral load. Coupled with vaccination, timely administration of safe and effective antivirals could provide a path towards managing COVID-19 without restrictive non-pharmaceutical measures. Here, we estimate the population-level impacts of expanding treatment with Paxlovid in the US using a multi-scale mathematical model of SARS-CoV-2 transmission that incorporates the within-host viral load dynamics of the Omicron variant. We find that, under a low transmission scenario (Re∼1.2) treating 20% of symptomatic cases would be life and cost saving, leading to an estimated 0.26 (95% CrI: 0.03, 0.59) million hospitalizations averted, 30.61 (95% …

Development Of Antiviral Peptidomimetics, Songyi Xue

USF Tampa Graduate Theses and Dissertations

Protein-protein interactions (PPIs) are essential for biological processes and are associated with a number of diseases, including cancer, infectious diseases, and neurodegenerative diseases. As a result, modulation of PPIs has been recognized as one of the most promising strategies to develop the novel drugs. Peptide modulators always exhibit higher specificity and affinities with targets than small compounds or monoclonal antibodies, but their broad medicinal effectiveness is constrained by their poor bioavailability and biostability. Peptidomimetics, which have been developed to mimic the structure as well as function of bioactive peptides and proteins, have shown excellent potential in protein surface mimicry and …

The Molecular Biophysics Of Extracellular Vimentin And Its Role In Pathogen–Host Interactions, Sepideh Parvanian, Leila S. Coelho-Rato, John E. Eriksson, Alison E. Patteson

Physics - All Scholarship

Vimentin, an intermediate filament protein typically located in the cytoplasm of mesenchymal cells, can also be secreted as an extracellular protein. The organization of extracellular vimentin strongly determines its functions in physiological and pathological conditions, making it a promising target for future therapeutic interventions. The extracellular form of vimentin has been found to play a role in the interaction between host cells and pathogens. In this review, we first discuss the molecular biophysics of extracellular vimentin, including its structure, secretion, and adhesion properties. We then provide a general overview of the role of extracellular vimentin in mediating pathogen-host interactions, with …

An Implementation Of The Method Of Moments On Chemical Systems With Constant And Time-Dependent Rates, Emmanuel O. Adara, Roger B. Sidje

Northeast Journal of Complex Systems (NEJCS)

Among numerical techniques used to facilitate the analysis of biochemical reactions, we can use the method of moments to directly approximate statistics such as the mean numbers of molecules. The method is computationally viable in time and memory, compared to solving the chemical master equation (CME) which is notoriously expensive. In this study, we apply the method of moments to a chemical system with a constant rate representing a vascular endothelial growth factor (VEGF) model, as well as another system with time-dependent propensities representing the susceptible, infected, and recovered (SIR) model with periodic contact rate. We assess the accuracy of …

Optimal Control Analysis Of The Dynamics Of Covid-19 With Application To Ethiopian Data, Temesgen Duresa Keno, Fekadu Mosisa Legesse, Ebisa Olana Bajira

Applied Mathematics & Information Sciences

In this paper, we proposed an optimal control of the COVID-19 transmission dynamics. First, we investigated system features such as solution boundedness, positivity, disease-free and endemic equilibrium, and the local and global stability of equilibrium points. Besides, a disease-free equilibrium point is globally asymptotically stable if the basic reproduction number is less than one, and an endemic equilibrium point exists otherwise. Secondly, we have shown the sensitivity analysis of the basic reproduction number. Also the model is then fitted using COVID-19 infected reported in Ethiopia from February 1,2023 to March 2,2023. The values of model parameters are then estimated from …

Construction And Performance Optimization Of Bioconjugated Nanosensors For Early Detection Of Breast Cancer And Pro-Inflammatory Diseases, Pooja Gaikwad

Dissertations, Theses, and Capstone Projects

In recent years, nanosensors have emerged as a tool with strong potential in medical diagnostics. Single-walled carbon nanotube (SWCNT) based optical nanosensors have notably garnered interest due to the unique characteristics of their near-infrared fluorescence emission, including tissue transparency, photostability, and various chiralities with discrete absorption and fluorescence emission bands. Additionally, the optoelectronic properties of SWCNT are sensitive to the surrounding environment, which makes them suitable for in vitro and in vivo biosensing. Single-stranded (ss) DNA-wrapped SWCNTs have been reported as optical nanosensors for cancers and metabolic diseases. Breast cancer and cardiovascular diseases are the most common causes of death …

Mineral Licks As A Potential Nidus For Parasite Transmission, William J. Severud, Todd M. Kautz, Jerrold L. Belant, Seth A. Moore

Natural Resource Management Faculty Publications

Discrete landscape features can concentrate animals in time and space, leading to non-random interspecific encounters. These encounters have implications for predator-prey interactions, habitat selection, intraspecific competition, and transmission of parasites and other pathogens. The lifecycle of the parasitic nematode Parelaphostrongylus tenuis requires an intermediate host of a terrestrial gastropod. Natural hosts of P. tenuis are whitetailed deer, and an aberrant host of conservation concern is moose, which are susceptible to high levels of mortality as a naive host to the parasite. Intermediate hosts become infected when P. tenuis larvae are shed in deer feces, then consumed or enter the gastropod …

Antiviral Susceptibility Of Clade 2.3.4.4b Highly Pathogenic Avian Influenza A(H5n1) Viruses Isolated From Birds And Mammals In The United States, 2022, Ha T. Nguyen, Anton Chesnokov, Juan De La Cruz, Philippe Noriel Q. Pascua, Vasiliy P. Mishin, Yunho Jang, Joyce Jones, Han Di, Andrei A. Ivashchenko, Mary Lea Killian, Mia K. Torchetti, Kristina Lantz, David E. Wentworth, Charles T. Davis, Alexandre V. Ivachtchenko, Larisa V. Gubareva

United States Department of Agriculture Wildlife Services: Staff Publications

Clade 2.3.4.4b highly pathogenic avian influenza (HPAI) A(H5N1) viruses that are responsible for devastating outbreaks in birds and mammals pose a potential threat to public health. Here, we evaluated their susceptibility to influenza antivirals. Of 1,015 sequences of HPAI A(H5N1) viruses collected in the United States during 2022, eight viruses (∼0.8%) had a molecular marker of drug resistance to an FDA-approved antiviral: three adamantane-resistant (M2-V27A), four oseltamivir-resistant (NA-H275Y), and one baloxavir-resistant (PA-I38T). Additionally, 31 viruses contained mutations that may reduce susceptibility to inhibitors of neuraminidase (NA) (n = 20) or cap-dependent endonuclease (CEN) (n = 11). A panel of 22 …

Bacterial Motion And Spread In Porous Environments, Yasser Almoteri

Dissertations

Micro-swimmers are ubiquitous in nature from soil and water to mammalian bodies and even many technological processes. Common known examples are microbes such as bacteria, micro-algae and micro-plankton, cells such as spermatozoa and organisms such as nematodes. These swimmers live and have evolved in multiplex environments and complex flows in the presence of other swimmers and types, inert particles and fibers, interfaces and non-trivial confinements and more. Understanding the locomotion and interactions of these individual micro-swimmers in such impure viscous fluids is crucial to understanding the emergent dynamics of such complex systems, and to further enabling us to control and …

Forecasting Stock Indices With The Covid-19 Infection Rate As An Exogenous Variable, Mohammad Saha A. Patwary

School of Computing and Informatics

Forecasting stock market indices is challenging because stock prices are usually nonlinear and non- stationary. COVID-19 has had a significant impact on stock market volatility, which makes forecasting more challenging. Since the number of confirmed cases significantly impacted the stock price index; hence, it has been considered a covariate in this analysis. The primary focus of this study is to address the challenge of forecasting volatile stock indices during Covid-19 by employing time series analysis. In particular, the goal is to find the best method to predict future stock price indices in relation to the number of COVID-19 infection rates. …

Cytokine Data For Cytokine Profile Assessment From Peruvian Pinniped (Arctocephalus Australis And Otaria Byronia) Plasma, Mykenzee Munaco, Milton Levin, Michael Adkesson, Susana Cárdenas-Alayzad, Dimitrios G. Giarikos, Amy C. Hirons

SECLER Data

Large colonies of two vulnerable, sympatric pinniped species, Peruvian fur seals (Arctocephalus australis Peruvian subpopulation; PFS) and South American sea lions (Otaria byronia; SASL), reside and reproduce in Punta San Juan, Peru (PSJ) where they are exposed to stressors such as contaminants and El Niño Southern Oscillation (ENSO) events. The use of cytokines as immune biomarkers can be indicative of an animal’s health and function by allowing for the assessment of an individual's cytokine balance as type I helper T cells (Th1) or type II helper T cells (Th2) dominant. Utilizing archived pinniped plasma samples from 2009-2019 …

Stability Analyses On The Effect Of Vaccination And Contact Tracing In Monkeypox Virus Transmission, Solomon Eshun, Richmond Essieku, James Ladzekpo

School of Mathematical & Statistical Sciences Faculty Publications

Monkeypox is a significant health concern due to its potential for morbidity and occasional mortality. Vaccination and effective contact tracing play pivotal roles in controlling infectious diseases, including monkeypox. This study aims to contribute to our understanding of monkeypox dynamics by developing a comprehensive mathematical model that incorporates key factors such as vaccination, quarantining, and contact tracing. Through rigorous sensitivity analysis, we explore the impact of varying vaccination coverage and contact tracing on the disease’s dynamics. In particular, we investigate the dynamics of the disease in relation to variable vaccination coverage and contact tracing. Our findings highlight the critical role …

Additive Effects Of Cyclic Peptide [R4w4] When Added Alongside Azithromycin And Rifampicin Against Mycobacterium Avium Infection, Melissa Kelley, Kayvan Sasaninia, Arbi Abnousian, Ali Badaoui, James Owens, Abrianna Beever, Nala Kachour, Rakesh Kumar Tiwari, Vishwanath Venketaraman

Pharmacy Faculty Articles and Research

Mycobacterium avium (M. avium), a type of nontuberculous mycobacteria (NTM), poses a risk for pulmonary infections and disseminated infections in immunocompromised individuals. Conventional treatment consists of a 12-month regimen of the first-line antibiotics rifampicin and azithromycin. However, the treatment duration and low antibiotic tolerability present challenges in the treatment of M. avium infection. Furthermore, the emergence of multidrug-resistant mycobacterium strains prompts a need for novel treatments against M. avium infection. This study aims to test the efficacy of a novel antimicrobial peptide, cyclic [R4W4], alongside the first-line antibiotics azithromycin and rifampicin in reducing M. avium survival. Colony-forming unit (CFU) …

Systematic Design And Data-Driven Evaluation Of Social Determinants Of Health Ontology (Sdoho), Yifang Dang, Fang Li, Xinyue Hu, Vipina K Keloth, Meng Zhang, Sunyang Fu, Muhammad F Amith, J Wilfred Fan, Jingcheng Du, Evan Yu, Hongfang Liu, Xiaoqian Jiang, Hua Xu, Cui Tao

Faculty, Staff and Student Publications

Objective: Social determinants of health (SDoH) play critical roles in health outcomes and well-being. Understanding the interplay of SDoH and health outcomes is critical to reducing healthcare inequalities and transforming a "sick care" system into a "health-promoting" system. To address the SDOH terminology gap and better embed relevant elements in advanced biomedical informatics, we propose an SDoH ontology (SDoHO), which represents fundamental SDoH factors and their relationships in a standardized and measurable way.

Material and methods: Drawing on the content of existing ontologies relevant to certain aspects of SDoH, we used a top-down approach to formally model classes, relationships, and …

Enhancing The Performance Of Microbial Fuel Cells Via Metabolic Engineering Of Escherichia Coli For Phenazine Production, Olja Simoska, Dale A. Cummings, Erin M. Gaffney, Claire Langue, Tommy G. Primo, Courtney J. Weber, Corbin E. Witt, Shelley D. Minteer

Chemistry Faculty Research & Creative Works

One of the central roles in the design, development, and application advances in mediator-Based microbial electrochemical systems, such as microbial fuel cells (MFCs), is the establishment of efficient and successful communication between conductive electrode surfaces and microorganisms via modes of extracellular electron transfer (EET). Most microbial-Based systems require the use of artificial electroactive mediators in order to facilitate and/or enhance electron transfer. Our previous work established an exogenous phenazine-Based library as a mediator system to enable EET from the model microorganism Escherichia coli as a promising biotechnological host. However, the addition of exogenous mediators to a microbial electrochemical system has …

The Devil You Know And The Devil You Don’T: Current Status And Challenges Of Bovine Tuberculosis Eradication In The United States, Daniel J. O'Brien, Tyler C. Thacker, Liliana C.M. Salvador, Anthony G. Duffiney, Suelee Robbe‑Austerman, Mark S. Camacho, Jason E. Lombard, Mitchell V. Palmer

United States Department of Agriculture Wildlife Services: Staff Publications

Having entered into its second century, the eradication program for bovine tuberculosis (bTB, caused by Mycobacterium bovis) in the United States of America occupies a position both enviable and daunting. Excepting four counties in Michigan comprising only 6109 km2 (0.06% of US land area) classified as Modified Accredited, as of April 2022 the entire country was considered Accredited Free of bTB by the US Department of Agriculture for cattle and bison. On the surface, the now well-described circumstances of endemic bTB in Michigan, where white-tailed deer (Odocoileus virginianus) serve as a free-ranging wildlife maintenance host, may appear to be …

Expanding One-Dimensional Game Theory-Based Group Decision Models: Extension To N-Dimension And Integration Of Distributed Position Function, Mirhossein Mousavi Karimi

Theses and Dissertations

This dissertation aims to expand the current one-dimensional game theory based model to a multidimensional model for multi-actor predictive analytics and generalize the concept of position to address problems where actors’ positions are distributed over a position spectrum. The one-dimensional models are used for the problems where actors are interacting in a single issue space only. This is less than an ideal assumption since, in most cases, players’ strategies may depend on the dynamics of multiple issues when dealing with other players. In this research, the one-dimensional model is expanded to N-Dimensional model by considering different positions, and separate salience …