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Role Of Nicotine In Oxidative Stress, Rakesh Kacham

Masters Theses

"Nicotine, a major alkaloid, is present in tobacco products as well as in smaller amounts in potatoes, tomatoes, and eggplants. Although it is the addictive compound in cigarettes, nicotine is believed to play a protective role in neurodegenerative disorders such as Parkinson's disease. Researchers have found that the short-term administration of nicotine may help improve the memory process by reducing oxidative stress in the brain. Our studies have shown that, by blocking Fenton's reaction, nicotine is able to inhibit free radical generation, so this research has focused on the antioxidant properties of nicotine. The cell lines of the alveoli, blood …

The Bio-Nano-Interface In Predicting Nanoparticle Fate And Behaviour In Living Organisms: Towards Grouping And Categorising Nanomaterials And Ensuring Nanosafety By Design, Hugh Byrne, Arti Ahluwalia, Diana Boraschi,, Bengt Fadeel, Peter Gehr, Arno C. Gutleb, Michaela Kendall, Manthos Papadopoulos, Iseult Lynch

Articles

In biological media, nanoparticles acquire a coating of biomolecules (proteins, lipids, polysaccharides) from their surroundings, which reduces their surface energy and confers a biological identity to the particles. This adsorbed layer is the interface between the nanomaterial and living systems and therefore plays a significant role in determining the fate and behaviour of the nanoparticles. This review summarises the state of the art in terms of understanding the bio-nano interface and provides direction for potential future research directions and some recommendations for future priorities and strategies to support the safe implementation of nanotechnologies. The central premise is that nanomaterials must …

Spectroscopic Study Of Charge Transfer Induced Blue Shifting Of Pyrimidine/Water Mixtures On Silver Substrate, Annie Katherine Mcclellan

Honors Theses

Surface enhanced Raman spectroscopy (SERS) is a chemical method gaining much popularity in recent years. With the use of a roughened metal surface or metal nanoparticles, surface plasmon resonances enhance the electromagnetic field allowing for increased Raman signal. Pyrimidine, having two lone pairs of electrons, is capable of charge transfer interactions contributing to a SERS chemical enhancement factor as well. It has recently been reported that hydrogen bonding with water results in the blue-shifting of certain normal modes of pyrimidine. By comparing experimental polarized Raman spectra with the results of electronic structure calculations, the origin of this blue-shifting was found …

Applications Of Agent Based Approaches In Business: A Three Essay Dissertation, Shankar Prawesh

USF Tampa Graduate Theses and Dissertations

The goal of this dissertation is to investigate the enabling role that agent based simulation plays in business and policy. The aforementioned issue has been addressed in this dissertation through three distinct, but related essays. The first essay is a literature review of different research applications of agent based simulation in various business disciplines, such as finance, economics, information systems, management, marketing and accounting. Various agent based simulation tools to develop computational models are discussed. The second essay uses an agent-based simulation approach to study important properties of the widely used most popular news recommender systems (NRS). This essay highlights …

The Effects Of River Sediment, Endosulfan, And Moderate Hypoxia On Blue Crabs (Callinectes Sapidus) From The Tidal, Freshwater James River, Laura Williams

Theses and Dissertations

Juvenile male blue crabs move into the tidal, freshwater James River during warmer months to feed and grow by undergoing molting. In crustaceans, growth and molting are hormonally controlled. The physiological effects of a multiple-stressor environment are determined by comparing the blue crab’s oxygen uptake after exposure to pure sand, James River sediment, or endosulfan-spiked sand. The effect of multiple stressors on molting is measured by the activity level of N-acetyl-ß-glucosaminidase (NAG), an enzyme in epidermal tissue important to molting. The oxygen uptake was decreased by exposure to James River sediment but not for exposure to endosulfan for seven days. …

Automatic Generation Of Music For Inducing Emotive And Physiological Responses, Kristine Perry Monteith

Theses and Dissertations

Music and emotion are two realms traditionally considered to be unique to human intelligence. This dissertation focuses on furthering artificial intelligence research, specifically in the area of computational creativity, by investigating methods of composing music that elicits desired emotional and physiological responses. It includes the following: an algorithm for generating original musical selections that effectively elicit targeted emotional and physiological responses; a description of some of the musical features that contribute to the conveyance of a given emotion or the elicitation of a given physiological response; and an account of how this algorithm can be used effectively in two different …

A Reexamination Of The Eastern Collared Lizard (Crotaphytus Collaris Collaris) In Arkansas, Ashley A. Grimsley

Graduate Theses and Dissertations

Loss of suitable habitat is a threat to species worldwide. Habitat destruction, including loss, change, and fragmentation of habitat, is the leading cause of species extinction. Eastern collared lizards (Crotaphytus collaris collaris) are habitat specialists on glades. Both C. c. collaris and glade habitats are rare and of special concern in the state of Arkansas. Many glade populations have already been extirpated in the Ozarks of Arkansas and Missouri. Increasing knowledge of the distribution, habitat structure, and population dynamics of C. c. collaris is important to ensure the survival of this species in Arkansas.

A literature review of …

A Physiological Signal Processing System For Optimal Engagement And Attention Detection., Ashwin Belle

Theses and Dissertations

In today’s high paced, hi-tech and high stress environment, with extended work hours, long to-do lists and neglected personal health, sleep deprivation has become common in modern culture. Coupled with these factors is the inherent repetitious and tedious nature of certain occupations and daily routines, which all add up to an undesirable fluctuation in individuals’ cognitive attention and capacity. Given certain critical professions, a momentary or prolonged lapse in attention level can be catastrophic and sometimes deadly. This research proposes to develop a real-time monitoring system which uses fundamental physiological signals such as the Electrocardiograph (ECG), to analyze and predict …

An Integrated Data Mining Approach To Real-Time Clinical Monitoring And Deterioration Warning, Yi Mao, Wenlin Chen, Yixin Chen, Chenyang Lu

All Computer Science and Engineering Research

Clinical study found that early detection and intervention are essential for preventing clinical deterioration in patients, for patients both in intensive care units (ICU) as well as in general wards but under real-time data sensing (RDS). In this paper, we develop an integrated data mining approach to give early deterioration warnings for patients under real-time monitoring in ICU and RDS. Existing work on mining real-time clinical data often focus on certain single vital sign and specific disease. In this paper, we consider an integrated data mining approach for general sudden deterioration warning. We synthesize a large feature set that includes …

Electrokinetic Properties Of Lipid And Sarcoplasmic Reticulum Membranes In Aqueous Electrolyte And In The Presence Of Lipophilic Ions, Laura Elizabeth Satterfield

Dissertations and Theses

The purpose of this study is the characterization of the membrane-water interfaces of both sarcoplasmic reticulum membrane (SR) and charged lipid bilayers under varied properties of the surrounding aqueous solution. In this work we studied the electrokinetic properties of liposomes and SR vesicles as well as the interaction of lipophilic ions with these membranes. The study of electrokinetic properties is based on the measurements of electrophoretic mobility of SR membrane vesicles and PC/PG liposomes. Electrophoretic mobility of SR vesicles was measured as a function of ionic strength for six pH values (pH 4.0, 4.7, 5.0, 6.0, 7.5, and 9.0). Electrophoretic …

Morality In The Virtual Space: Applying Moral Philosophy To Digital Worlds, James O'Sullivan

Theses

Since the turn of the century and the dawn of the digital age, online communities have witnessed significant growth in their importance. Significant numbers of virtual environments now exist, within which millions of individuals interact socially and economically, engaged fully in what is equivalent to a physical encounter, the only differences being the virtual representations through which they interact, and the physical security that this representation affords them. Though physically absent, individuals are fully engaged psychologically, and thus open to the same ethical dilemmas presented through reality. Application of real-world moral codes is encumbered by the existence of what 1 …

Gene Transcription In Sea Otters (Enhydra Lutris); Development Of A Diagnostic Tool For Sea Otter And Ecosystem Health, Lizabeth Bowen, A. Keith Miles, Michael Murray, Martin Haulena, Judy Tuttle, William Van Bonn, Lance Adams, James L. Bodkin, Brenda Ballachey, James A. Estes, M. Tim Tinker, Robin Keister, Jeffrey L. Stott

United States Geological Survey: Staff Publications

Gene transcription analysis for diagnosing or monitoring wildlife health requires the ability to distinguish pathophysiological change from natural variation. Herein, we describe methodology for the development of quantitative real-time polymerase chain reaction (qPCR) assays to measure differential transcript levels of multiple immune function genes in the sea otter (Enhydra lutris); sea otter-specific qPCR primer sequences for the genes of interest are defined. We establish a ‘reference’ range of transcripts for each gene in a group of clinically healthy captive and free-ranging sea otters. The 10 genes of interest represent multiple physiological systems that play a role in immuno-modulation, …

A Simple Approach For Synthesis, Characterization And Bioactivity Of Bovine Bones To Fabricate The Polyurethane Nanofiber Containing Hydroxyapatite Nanoparticles, Faheem A. Sheikh, M. A. Kanjwal, Javier Macossay-Torres, N. A. M. Barakat, H. Y. Kim

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

In the present study, we had introduced polyurethane (PU) nanofibers that contain hydroxyapatite (HAp) nanoparticles (NPs) as a result of an electrospinning process. A simple method that does not depend on additional foreign chemicals had been employed to synthesize HAp NPs through the calcination of bovine bones. Typically, a colloidal gel consisting of HAp/PU had been electrospun to form nanofibers. In this communication, physiochemical aspects of prepared nanofibers were characterized by FE-SEM, TEM and TEM-EDS, which confirmed that nanofibers were well-oriented and good dispersion of HAp NPs, over the prepared nanofibers. Parameters, affecting the utilization of the prepared nanofibers in …

Single-Molecule Detection Of Molecular Beacons Generated From Ldr On Thermoplastic Microfluidic Device For Bioanalysis, Zhiyong Peng

LSU Doctoral Dissertations

Current clinical techniques for nucleic acid detection and analysis often involve PCR, lacking adequate specificity or sensitivity to meet the stringent requirements in certain applications. This research aims to develop an innovative molecular assay and the associated hardware to rapidly signal the presence of certain targets using reporter sequence found in their genome without requiring PCR. This assay coupled the sensitivity of single-pair fluorescence resonance energy transfer (spFRET) with the specificity of ligase detection reaction (LDR) to provide near real-time readout of target biomarkers. Heightened concerns on potential bioterrorism threats, such as rapid dissemination of pathogenic bacteria or viruses into …

A Hierarchical Image Processing Approach For Diagnostic Analysis Of Microcirculation Videos, Nazanin Mirshahi

Theses and Dissertations

Knowledge of the microcirculatory system has added significant value to the analysis of tissue oxygenation and perfusion. While developments in videomicroscopy technology have enabled medical researchers and physicians to observe the microvascular system, the available software tools are limited in their capabilities to determine quantitative features of microcirculation, either automatically or accurately. In particular, microvessel density has been a critical diagnostic measure in evaluating disease progression and a prognostic indicator in various clinical conditions. As a result, automated analysis of the microcirculatory system can be substantially beneficial in various real-time and off-line therapeutic medical applications, such as optimization of resuscitation. …

Mathematical Modeling Of Peristaltic Flow Of Chyme In Small Intestine, Daniel N. Riahi, Ranadhir Roy

Applications and Applied Mathematics: An International Journal (AAM)

Mathematical models based on axisymmetric Newtonian incompressible fluid flow are studied for the peristaltic flow of chyme in the small intestines, which is an axisymmetric cylindrical tube. The flow is modeled more realistically modeled by assuming that the peristaltic rush wave is a non-periodic mode composed of two sinusoidal waves of different wavelengths, which propagate at the same speed along the outer boundary of the tube. Both cases of flow in a tube and in an annulus that are modeled and investigated in the present paper correspond respectively to the cases of flow of chyme in the small intestine in …

Processing And Classification Of Physiological Signals Using Wavelet Transform And Machine Learning Algorithms, Abed Al-Raoof Bsoul

Theses and Dissertations

Over the last century, physiological signals have been broadly analyzed and processed not only to assess the function of the human physiology, but also to better diagnose illnesses or injuries and provide treatment options for patients. In particular, Electrocardiogram (ECG), blood pressure (BP) and impedance are among the most important biomedical signals processed and analyzed. The majority of studies that utilize these signals attempt to diagnose important irregularities such as arrhythmia or blood loss by processing one of these signals. However, the relationship between them is not yet fully studied using computational methods. Therefore, a system that extract and combine …

Investigation Of Extremely Low Frequency (Elf) Hot Spots In The College Of Science And Technology, Covenant University, Ota, Marvel Akinyemi, John Kayode, Mojisola Usikalu

Turkish Journal of Physics

The presence of Extremely Low Frequency (ELF) from electronic devices such as personal computers, laboratory equipment and television sets in selected laboratories and offices at the College of Science and Technology Building, Covenant University, Ota, Nigeria was characterized using an ELF Detection Meter. The study revealed that exposure to ELF fields could be controlled to the minimum depending on the awareness of the occupant. As with all electromagnetic fields, the ELF field decays rapidly with distance from source or hot spots. The average observed value of ELF in the offices ranged from 3.5 to 5.0 mG. A significant hot spot …

Modified Chromenes As Precursors To Taar Regulators, Jonathan Lehmann, Matthew Hart

Student Summer Scholars Manuscripts

200 million people worldwide are living with a thyroid disorder related to a hormonal imbalance. Symptoms of this imbalance include deviations from normal heart rates and metabolic rates. A chemical messenger known as T3 has been shown to raise cardiac and metabolic rates, but this takes place on a timescale of hours. However, recent discoveries have revealed that a different thyroid hormone known as T1AM is capable of affecting some of these same physiological conditions in a matter of minutes. T1AM is a potent, selective agonist for the Trace Amine Associated Receptor (TAAR). Several studies have probed the structural basis …

Experimental Evaluation Of Transmission Link Characteristics In Body Area Networks, Apoorva Kiran Pandya

School of Computing: Dissertations, Theses, and Student Research

Recent advances in digital electronics, embedded systems, and wireless communications have led the way to a new class of distributed Wireless Sensor Networks (WSNs). A Body Area Network (BAN) is a WSN consisting of miniaturized, low-power, autonomous, wireless biosensors, which are seamlessly placed or implanted in the human body to provide an adaptable and smart health care system. The possible applications of BAN are in health care services and medicine, assisting persons with disabilities, and entertainment and sports. The nodes in a BAN generally use IEEE 802.15.4 radios which have low- power consumption and are relatively immune to interference. In …

A Mathematical Model Of The Biofluidmechanics Of The Non-Newtonian Mucus Layer Of The Tear Film In The Human Eye, Douglas M. Platt

Theses, Dissertations and Culminating Projects

The human eye is a complicated and delicate organ. The structure of the eye is such that it provides for clear vision of the world. The cornea and conjunctiva at the front of the eye are avascular structures that require nutrients and moisture to be provided by the tear film. The tear film also provides for the removal of debris from the surface of the eye. The tear film has several layers: a lipid layer, an aqueous solution, and mucus. The optical clarity and structural uniformity of the tear film is maintained by the blinking motion of the eyelid. During …

4 Part Research Project: Cholecystokinin, Marcie Tasker

Academic Symposium of Undergraduate Scholarship

This 4 part research paper contains information on the biological molecule Cholecystokinin. The following research discusses and presents evidence of the name, history and structure of the hormone. It also discusses the different chemical reactions Cholecystokinin has in the body, the biological roles of Cholecystokinin and the importance of Cholecystokinin focusing specifically on the unexplained obesity issue of our world.

Open Notebook Science Challenge Solubilities Of Organic Compounds In Organic Solvents, Andrew Lang, Jean-Claude Bradley, Cameron Neylon, Rajarshi Guha, Antony J. Williams, Bill Hooker, Brent Friesen

College of Science and Engineering Faculty Research and Scholarship

The Open Notebook Science Solubility Challenge Solubility is an important consideration for many chemistry applications. Synthetic chemists usually use a solvent to perform reactions and knowledge of the solubility of the starting materials or products can be very useful to pick an appropriate solvent. Analytical chemists can use solubility to design separation techniques and factor in dynamic range considerations. Physical chemists can create and evaluate their models of how molecules interact in the solubilization and precipitation processes. Solubility data can be obtained from a variety of online and offline sources. As with all chemical data, it can be a challenge …

Begin The Adventure : How To Break The Light Barrier By A.D. 2079 (3rd Ed.), Florentin Smarandache, Homer B. Tilton

Branch Mathematics and Statistics Faculty and Staff Publications

This edition, the third, has undergone a subtle name change, going from "A.D. 2070" in the title to A.D. 2079 as the timeline is fine-tuned. Because of the almost universal failure to recognize the distinction between physical (reality-based, dynamical) and visual (appearance-based, kinematical) variables, a tremendous volume of mythology arose over the past 100 years centered around Einstein's reality view of the distortions of special relativity. To get a sense of it, we point the reader to Paul J. Nahin's heroic book, Time Machines, 2nd ed.,- to these Tech Notes in particular: TN#6. "A High-Speed Rocket Is a One-Way Time …

Automatic Generation Of Music For Inducing Emotive Response, Tony R. Martinez, Kristine Monteith, Dan A. Ventura

Faculty Publications

We present a system that generates original music designed to match a target emotion. It creates n-gram models, Hidden Markov Models, and other statistical distributions based on musical selections from a corpus representing a given emotion and uses these models to probabilistically generate new musical selections with similar emotional content. This system produces unique and often remarkably musical selections that tend to match a target emotion, performing this task at a level that approaches human competency for the same task.

Development Of Novel Ahr Antagonists, Hyosung Lee

University of Kentucky Doctoral Dissertations

Aryl hydrocarbon receptor (AHR) is a sensor protein, activated by aromatic chemical species for transcriptionally regulating xenobiotic metabolizing enzymes. AHR is also known to be involved in a variety of pathogenesis such as cancer, diabetes mellitus, cirrhosis, asthma, etc. The AHR signaling induced by xenobiotics has been intensively studied whereas its physiological role in the absence of xenobiotics is poorly understood. Despite a number of ligands of AHR have been reported thus far, further applications are still hampered by the lack of specificity and/or the partially agonistic activity. Thus, a pure AHR antagonist is needed for deciphering the AHR cryptic …

Fabrication Of Receptor-Modified Microfluidic Surfaces For Applications In Glycoprotein Screening, Jennifer Macalindong De Guzman

LSU Doctoral Dissertations

Glycoproteins have long been identified to have a profound association with human pathological processes, and they are much sought after as potential biomarkers to aid in the early diagnosis and clinical prognosis of cancers and diseases. There is currently high demand for high-throughput and low–limit–of–detection techniques that can afford profiling of the glycoproteome. Micro-total analysis systems (µTAS) based on microfluidics have the potential to fulfill these requirements, but in order to reduce the complexity of the protein pool, the µTAS devices must contain a pre-isolation and enrichment component. The research project undertaken here involved derivatization of microfluidic …

Sci-Tech Book News Reviews

Sci-Tech News

This section consists of 100 book reviews selected from Sci-Tech Book News, reprinted with the permission of Book News, Inc.

The Burden Of Fetching Water: Using Caloric Expenditure As An Indicator Of Access To Safe Drinking Water—A Case Study From Xieng Khouang Province, Lao Pdr, Jeff La Frenierre

Electronic Theses and Dissertations

The Millennium Development Goals measure ‘access to improved drinking water’ using an indicator that defines access as the presence of an improved water source within 1 kilometer of a person’s dwelling. This purely linear measurement has significant shortcomings, including a lack of consideration for the difficulty of the terrain being traversed and the weight of the loads being carried. This paper examines in detail the human energy costs associated with fetching water, first using two Lao villages as case studies, then applying a predictive energy expenditure model to measure the potential caloric effect of variations in the age and gender …

Breaking The Spell: Developing A New Generation Of Porphyrins For Treating Cerebral Tumors, Ryan Harrison Gray

Honors Capstones

No abstract provided.