Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Physical Sciences and Mathematics

Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 3931 - 3960 of 64990

Full-Text Articles in Entire DC Network

Understanding University-Level Food Recovery Programs’ Approaches To Minimizing Food Waste While Combating Food Insecurity In The United States, Ella F. Flesher May 2025

Understanding University-Level Food Recovery Programs’ Approaches To Minimizing Food Waste While Combating Food Insecurity In The United States, Ella F. Flesher

Crop, Soil and Environmental Sciences Undergraduate Honors Theses

Food is wasted every day at each level of the food system from production to consumption. This surplus has significant negative impacts on the environment after food is sent to the landfill and allowed to rot. However, some surplus food can be repurposed and diverted from the landfill. This study served as an initial investigation to explore multiple food waste diversion programs and analyze their structure, best practices, and methods to divert leftover food. This study specifically aimed to compare and contrast food recovery programs by interviewing participants from three food recovery programs from different university institutions. With the key …


Development Of Novel Pharmaceutical For Optimization Of Opioid Overdose Treatment, Larae Kram May 2025

Development Of Novel Pharmaceutical For Optimization Of Opioid Overdose Treatment, Larae Kram

Celebrating Scholarship and Creativity Day (2018-)

Although opioids are highly effective drugs for pain management, their overuse and addictive nature has caused an opioid epidemic, resulting in many cases of opioid addiction and overdose. There are two current opioid overdose drugs that are FDA approved: naloxone and nalmefene. These drugs have a higher affinity to the active binding pocket on the opioid receptor than opioids do and displace the opioids, preventing any further binding of the opioid and halting the opioid’s effects. However, naloxone is not active long enough to outlast the duration of the opioid and nalmefene causes severe withdrawal symptoms. The development of more …


Monitoring The Qosh Tepa Canal Project: A Geospatial Timeline Of Taliban Water Diversion, Enerel L. Crosslin May 2025

Monitoring The Qosh Tepa Canal Project: A Geospatial Timeline Of Taliban Water Diversion, Enerel L. Crosslin

Honors Thesis

The World Food Program states that “acute malnutrition in Afghanistan is above emergency thresholds in 25 out of 34 provinces and is expected to worsen”. Aiming to support agriculture, the Taliban began to build the 285 km “Qosh Tepa Canal” to divert 17% of the Amu Darya, which supports the livelihoods of millions of people in downstream Uzbekistan and Turkmenistan. The World Bank estimated that roughly 2.4 million Central Asians could become climate refugees by 2050. Our objectives are to create a timeline of satellite imagery of the canal’s construction. Our research questions are (1) Can we characterize water diversion …


Disulfide-Cleavable Linkers In Antibody-Drug Conjugates For Targeted Cancer Therapy, Emily Hwang May 2025

Disulfide-Cleavable Linkers In Antibody-Drug Conjugates For Targeted Cancer Therapy, Emily Hwang

Undergraduate Honors Thesis Collection

This project aims to discover a way to improve the safety of and reduce adverse side effects of disulfide-linked antibody-drug conjugates. Disulfide-cleavable linkers for antibody-drug conjugates function by exploiting the differential concentrations of dominant thiol species in the blood plasma and in the cytosol of malignant cells. This project aimed to identify a relationship between the stability of disulfide cleavable linkers in the blood plasma and disulfide linker structure, to prevent premature release of the cytotoxic drug. Three disulfide linker analogs with varying carbon chain lengths were synthesized through reaction with 2,2’-dipyridyl disulfide. Each analog was conjugated to a fluorescent …


Cultural Health Benefits And Challenges Of Food Preparation And Consumption: A Comparative Study Of The United States, Italy, And Norway, Natalie G. Link May 2025

Cultural Health Benefits And Challenges Of Food Preparation And Consumption: A Comparative Study Of The United States, Italy, And Norway, Natalie G. Link

Undergraduate Honors Thesis Collection

This study aims to investigate the cultural health benefits and challenges associated with food preparation and consumption in the United States, Italy, and Norway, with a particular focus on citizens in lower socioeconomic levels. By examining the dietary habits, social structures, and health outcomes in these three countries, this research aims to uncover broader insights into the health status and well-being of their respective populations. The study will employ secondary data analysis approach examining existing research on cultural practices and social support systems. The findings of this research will contribute to a deeper understanding of the complex interplay between food …


Impacts Of Cognitive Workload On Veteran Driver Reaction Time: Predictive Modeling Using Bayesian And Machine Learning Methods, Kenneth Ofosu-Kwabe May 2025

Impacts Of Cognitive Workload On Veteran Driver Reaction Time: Predictive Modeling Using Bayesian And Machine Learning Methods, Kenneth Ofosu-Kwabe

All Theses

In high-demand environments, the ability to manage cognitive workload can mean the difference between optimal or safe performance and critical failure or accidents. Veterans face an elevated risk of fatal motor vehicle accidents due to post-deployment stress, combat-related injuries, and challenges readjusting to civilian driving. This study explores how cognitive workload affects reaction time performance using a driving simulator by collecting and analyzing subjective workload ratings (using the NASA-TLX survey), physiological signals from eye-tracking and performance data from a sample of 28 Veterans.

We examined how task difficulty, cognitive indicators and personal attributes influence reaction times across an interactive driving …


Biodegradable Active Packaging: Exploring The Antimicrobial Efficacy And Compostability Of Chitosan-Based Films, Rachel Mchugh May 2025

Biodegradable Active Packaging: Exploring The Antimicrobial Efficacy And Compostability Of Chitosan-Based Films, Rachel Mchugh

All Theses

The overarching purpose of this experiment is to create an active packaging component that has both antimicrobial and biodegradable properties specifically designed for poultry food products. For the scope of this study, the packaging component created would theoretically be used in conjunction with another material, such as a poultry tray which are commonly used for fresh poultry products. Based on the scope and purpose of this experiment, biopolymer films and coatings were considered after the initial literature review. Due to the goals of the packaging component, chitosan, a polysaccharide shown to have antimicrobial properties and an inherent ability to biodegrade, …


Electrochemically Precipitated Struvite Effects On Extractable Soil Nutrients, Owen Collins May 2025

Electrochemically Precipitated Struvite Effects On Extractable Soil Nutrients, Owen Collins

Crop, Soil and Environmental Sciences Undergraduate Honors Theses

Struvite recovery from wastewater streams may provide an alternative to traditional fertilizer-phosphorus (P) sources, while also providing the benefit of reducing nitrogen and P loads in wastewater effluent and reducing effects of eutrophication in surface waters. Limited research has been conducted to assess the effects of struvite fertilization on concentrations of soil micronutrients and potassium (K) compared to other traditional fertilizer-P sources in historically agricultural soils. The objective of this study was to assess the effects of fertilizer-P source (i.e., synthetically produced electrochemically precipitated struvite [ECST], chemically precipitated struvite [CPST], monoammonium phosphate [MAP], diammonium phosphate [DAP], triple superphosphate [TSP], rock …


How Do Simulated Phishing Attacks Impact Cybersecurity Awareness And The Enhancement Of Security Protocols Among Faculty Members In A University Environment?, Navnoor Sandhu May 2025

How Do Simulated Phishing Attacks Impact Cybersecurity Awareness And The Enhancement Of Security Protocols Among Faculty Members In A University Environment?, Navnoor Sandhu

University Honors Program Senior Projects

Phishing attacks are cyber threats where attackers deceive users into performing actions that compromise the user’s security and benefit the attacker. In 2024 alone, phishing attacks have resulted in estimated damages of around 800 million dollars [1]. In response, many institutions have implemented internal simulated phishing attacks to enhance their employees' cybersecurity awareness. This training exercise has been proven beneficial in improving cybersecurity awareness on an enterprise scale[4]. This study aims to evaluate the potential effectiveness of a simulated phishing attack within a university setting, which is a relatively unseen practice thus far. Universities, like other secure organizations, store sensitive …


Thermal Biology Of The Eastern Treehole Mosquito Aedes Triseriatus (Diptera: Culcidae) And Other Vertivorous Dipterans, Kelly I. Zimmerman May 2025

Thermal Biology Of The Eastern Treehole Mosquito Aedes Triseriatus (Diptera: Culcidae) And Other Vertivorous Dipterans, Kelly I. Zimmerman

Theses, Dissertations and Culminating Projects

Temperature plays a critical role in mosquito life cycle, behavior, and other ecological interactions. My dissertation analyzed how temperature affects egg hatch rates of the eastern treehole mosquito (Aedes triseriatus) and how amino acid substitutions in TRPA1 correlated with host finding through thermotaxis and the convergent evolution of vertebrate feeding/utilizing in Dipterans. As ectotherms, embryonic development and egg hatch rates are directly influenced by the water temperature mosquito eggs are oviposited into. Ae. triseriatus eggs do not hatch all at once, to avoid potentially high larval mortality rates due to their non-static oviposition sites. They engage in staggered egg hatching, …


Advancing Drug-Drug Interaction Prediction Using Multi-Modal Feature Integration With Graph Neural Networks, Ernest C. Chianumba May 2025

Advancing Drug-Drug Interaction Prediction Using Multi-Modal Feature Integration With Graph Neural Networks, Ernest C. Chianumba

Theses, Dissertations and Culminating Projects

Pharmaceutical treatments are essential for managing medical conditions, but drug-drug interactions (DDIs) pose significant risks to patient safety and healthcare outcomes. This research integrates Knowledge Graphs and Graph Neural Networks to predict DDIs by exploring complex drug relationships. We construct a comprehensive knowledge graph using DrugBank data (1,000 drugs, 155,774 interactions) enriched with molecular features from PubChem. Our methodology introduces a novel multi-modal approach by integrating transformer-based embeddings (ChemBERTa, SPECTER, and SBERT) to create 1152-dimensional feature vectors that capture structural, biomedical literature, and semantic properties of drugs. Formulating DDI prediction as a link prediction task, we compare three Graph Neural …


Life Cycle Analysis Of Cosmetic Products -- Assessing Environmental Sustainability And Potential Impacts, Karina Magro Machado May 2025

Life Cycle Analysis Of Cosmetic Products -- Assessing Environmental Sustainability And Potential Impacts, Karina Magro Machado

Theses, Dissertations and Culminating Projects

The cosmetic industry has a significant environmental footprint due to its reliance on water, energy, petrochemical-derived ingredients, and plastic-based packaging. This study performs a cradle-to-grave Life Cycle Analysis (LCA) to evaluate the environmental impacts of three cosmetic products: CeraVe Daily Moisturizing Lotion, bareMinerals Gen Nude Powder Blush, and Gillette Foamy Regular Shave Cream. The analysis was conducted using OpenLCA software and free databases, modeling each product across raw materials, packaging, manufacturing, transportation, use and end-of-life phases. The results showed that the shave cream had the highest environmental burden to three out of the four categories, especially in consumption and carbon …


Don't Let Lead Lead On Environmental Justice: A Simulative Approach To Lead Remediation In The Big Data Era, Charles C. Knoble Ii May 2025

Don't Let Lead Lead On Environmental Justice: A Simulative Approach To Lead Remediation In The Big Data Era, Charles C. Knoble Ii

Theses, Dissertations and Culminating Projects

Environmental justice, as both a movement and a theoretical construct, continues to evolve in response to shifting societal, environmental, and technological conditions. This dissertation investigates the integration of big data, such as social media, remote sensing imagery, and internet search frequencies, into the identification, analysis, and remediation of environmental injustices. Framing environmental justice through the lenses of distributive and data justice, the project explores both the promises and pitfalls of using emergent data sources to enhance the spatial and temporal precision of environmental equity investigations. Through a combination of systematic literature review, spatial analysis, system dynamics simulation, and policy evaluation, …


How The Ramapough Turtle Clan Tribe Sustained Their Culture Through Ford's Environmental Exploitation, Tori Sutera May 2025

How The Ramapough Turtle Clan Tribe Sustained Their Culture Through Ford's Environmental Exploitation, Tori Sutera

Theses, Dissertations and Culminating Projects

The Ramapough Turtle Clan Tribe is an Indigenous community composed of individuals residing mainly in Ringwood, New Jersey and a few surrounding boroughs. This land holds irreplaceable significance among the community, who, after facing colonial diaspora, have ultimately resided in Ringwood. However, due to the vast effects of the Ringwood Superfund site, this community has dealt with the loss of their people and their culture. Beginning in 1967, Ford Motor Company – partial owners of the site at that time – initiated the dumping of heavily toxic materials into Cannon and Peters Mines. This dumping continued until 1971, and the …


Analysis And Mathematical Recomposition Of The Art Of The Fugue, Joshua Cellar May 2025

Analysis And Mathematical Recomposition Of The Art Of The Fugue, Joshua Cellar

Theses, Dissertations and Culminating Projects

The Art of the Fugue is a collection of 18 fugues and cannons written by Johann Sebastian Bach in the 1700s. Each piece starts with a single theme which is transformed, developed and mixed in fascinating mathematical combinations resulting in a distinctive musical style. In this paper, we use the method introduced in [7] to analyze 14 pieces from The Art of the Fugue. We focus on the variation of motifs from one piece to another as well as the complexities of mathematical transformations present throughout the entire collection. We also demonstrate how using maps of transformations and the rules …


Tracking Fall Migration With The Motus Wildlife Tracking System: The Fate Of Window-Struck And Captive-Raised Passerines, Cailin O'Connor May 2025

Tracking Fall Migration With The Motus Wildlife Tracking System: The Fate Of Window-Struck And Captive-Raised Passerines, Cailin O'Connor

Theses, Dissertations and Culminating Projects

Many species of North American passerines migrate along the Atlantic flyway in the fall to reach winter habitats in the southeastern United States, the Caribbean, and Central and South America. Birds face many perils along their journeys including window strikes, which kill over one billion birds per year in the United States alone. Some birds survive the impact and may continue their migration. These birds may suffer delayed mortality or show aberrant migration due to injuries. This research seeks to understand if window-struck birds that initially survive bird-building collisions survive into the future and, if so, if they migrate effectively. …


How Will Artificial Intelligence Impact The Roles, Skills, And Design Processes Of Ux Professionals In The Next 5 Years?, Olivia Behan May 2025

How Will Artificial Intelligence Impact The Roles, Skills, And Design Processes Of Ux Professionals In The Next 5 Years?, Olivia Behan

Informatics

Artificial intelligence (AI) is changing the way we think about user experience (UX) design. This thesis explores how AI could impact the roles, skills, and design processes of UX professionals over the next five years. The research conducted consists of a mixed-methods approach, combining an online survey administered through Qualtrics to 50 survey respondents and a case study, which included individually interviewing 3 UX professionals over Zoom, to gather data and personal insights. The results show that while AI has the power and potential to make some parts of UX work faster, like research analysis, prototyping, and automating redundant tasks, …


Reducing Stigma Around Neurodiversity Through The Use Of Celebratory Technology Ice Breakers In First-Year Undergraduate Classrooms, Briana Craig May 2025

Reducing Stigma Around Neurodiversity Through The Use Of Celebratory Technology Ice Breakers In First-Year Undergraduate Classrooms, Briana Craig

Electrical Engineering and Computer Science (MS) Theses

Celebratory technology for Neurodiversity is a new paradigm in the field of human computer interaction; it focuses on reducing stigma surrounding neurodivergent labels and behaviors. Celebratory technology aims to highlight the strengths of neurodiversity rather than fixing socially undesired traits, shifting the responsibility for change from neurodivergent individuals to society's attitudes. Stigma reduction can be accomplished through providing high quality interactions, where anyone can meet and learn about positive traits in others as well as learn of interests' others have in common, thus reframing neurodivergence as inclusion in human diversity rather than a condition to be stigmatized or objectified. This …


An Analysis Of Bias Towards Women In Large Language Models Using Likert Scale Evaluations, Sarah T. Fieck May 2025

An Analysis Of Bias Towards Women In Large Language Models Using Likert Scale Evaluations, Sarah T. Fieck

Electrical Engineering and Computer Science (MS) Theses

Closed-source large language models (LLMs) developed by large technology companies continue to grow in popularity. However, ethical conversations surrounding the safety of model outputs have been a prominent topic of discussion. This project aims to assess three leading closed-source LLMs: OpenAI’s ChatGPT, Google’s Gemini, and Anthropic’s Claude, to analyze how their outputs perform when treated as a subject of several psychological evaluation scales measuring biased behaviors against women. The Ambivalent Sexism Index, Modern Sexism Scale, and Belief in Sexism Shift evaluations were used to get descriptions of how the LLMs respond to traditional and modern prompts involving sexism and gender …


Compartmental Disaggregation: Bridging Simulation And Sampling Methods For Synthetic Population Data Generation, Dylan Mack May 2025

Compartmental Disaggregation: Bridging Simulation And Sampling Methods For Synthetic Population Data Generation, Dylan Mack

McKelvey School of Engineering Graduate Student Theses & Dissertations

As agent-based models (ABMs) grow increasingly widespread in public health, their associated challenges have become all the more significant. Lauded for their ability to capture population heterogeneity, nonlinear dynamics, and emergent behaviors, disease ABMs are also computationally expensive and often require detailed inputs that describe each agent at the individual-level, known as synthetic population data. Current approaches for synthetic population data generation generally fall into one of two categories: sampling or simulation. These methods are both feasible only under restricted conditions and suffer from challenges surrounding data availability and computing power. This thesis proposes compartmental disaggregation, an intermediate method for …


Antiproliferative Effects Of Salvia On Breast Cancers., Allison C. Portaro May 2025

Antiproliferative Effects Of Salvia On Breast Cancers., Allison C. Portaro

College of Arts & Sciences Senior Theses

Breast cancer is the most common cancer diagnosed in female adults, with 2.3 million new cases worldwide in 2020. Plants have been used in traditional medicine and are a potential source of pharmaceuticals. One example is the large Lamiaceae (mint) family. The Salvia genus, commonly known as the sages, is the largest genus in Lamiaceae with almost 900 known species. Salvia lyrata (lyre-leaved sage) has a history of Native American medicinal use to treat cancers and other ailments resulting in this plant being referred to as ‘cancer weed.’ Extracts were produced from the leaves of S. lyrata, S. lyrata …


Shortage To Surge - Studying The Post-Covid-19 Guitar Retail Market, Jed H. Kim May 2025

Shortage To Surge - Studying The Post-Covid-19 Guitar Retail Market, Jed H. Kim

Data Science Undergraduate Honors Theses

The COVID-19 pandemic was one of the most catalyzing events of the 21st century, leading to supply chain disruptions, lifestyle changes, and a massive shift towards digital technologies. During the COVID-19 lockdown, many people had more free time, and over 16 million individuals learned to play guitar in the first 2 years of the pandemic. According to a study by Fender, 62% of these new guitar learners cited the pandemic as their primary reason for learning the instrument. However, pandemic policies and supply chain disruptions meant that many guitar retailers were unable to satisfy demand, and backorders accumulated. After the …


Reinforcement Learning, Modeling Markets, And Professional Basketball Free Agency, Jacob Cohn May 2025

Reinforcement Learning, Modeling Markets, And Professional Basketball Free Agency, Jacob Cohn

Computational and Data Sciences (PhD) Dissertations

This dissertation presents a reinforcement learning-based approach to modeling and optimizing decision-making in professional basketball free agency and related economic environments. A Markov Decision Process (MDP) framework is introduced to capture the strategic interactions of NBA teams bidding for free agents under budgetary and roster constraints. To address computational scalability challenges, a reinforcement learning (RL) environment is developed, leveraging Proximal Policy Optimization (PPO) to approximate optimal policies for team decision-making.

Empirical results demonstrate that the RL agent successfully learns strategic bidding behavior that aligns with dynamic programming benchmarks in simplified settings while scaling effectively to larger, intractable environments. The study …


Mitigating Nitrogen Losses: The Role Of Enhanced Efficiency Fertilizers In Sustainable Corn Production, Dipesh Giri May 2025

Mitigating Nitrogen Losses: The Role Of Enhanced Efficiency Fertilizers In Sustainable Corn Production, Dipesh Giri

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

Nitrogen (N) is essential for crop production, but its inefficient use often leads to environmental losses through nitrate leaching, ammonia volatilization, and nitrous oxide (N₂O) emissions. Enhanced efficiency fertilizers (EEFs), such as nitrification inhibitors (NIs) and urease inhibitors (UIs), have been developed to minimize these losses and improve nitrogen use efficiency (NUE). This research combined a multi-year field experiment and a controlled laboratory study to evaluate how dual-inhibitor fertilizers compare to conventional urea and single-inhibitor formulations in Nebraska cropping systems. The main objective was to understand how nitrogen inhibitors influence N availability, crop performance, and nitrogen losses across different environmental …


Extending Cover Crop Growing Window To Improve The Health Of Environmentally Sensitive Soils, Noshin Ara Tunazzina May 2025

Extending Cover Crop Growing Window To Improve The Health Of Environmentally Sensitive Soils, Noshin Ara Tunazzina

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

Sloping and sandy soils are highly susceptible to degradation. The health of these soils could be improved with cover crops (CCs). However, CC effectiveness in improving soil health mainly depends on CC biomass production, which is often low in temperate regions. The question is: how can we increase CC biomass production? Lengthening the CC growing window can be a potential strategy. This study assessed how 1) interseeded and terminated early (2-3 weeks before crop planting) CC, 2) interseeded and terminated late (at crop planting) CC, 3) drilled (after harvest) and terminated early CC, 4) drilled and terminated late CC, and …


Rotation-Adaptive Point Cloud Domain Generalization Via Intricate Orientation Learning, Bangzhen Liu, Chenxi Zheng, Xuemiao Xu, Cheng Xu, Huaidong Zhang, Shengfeng He May 2025

Rotation-Adaptive Point Cloud Domain Generalization Via Intricate Orientation Learning, Bangzhen Liu, Chenxi Zheng, Xuemiao Xu, Cheng Xu, Huaidong Zhang, Shengfeng He

Research Collection School Of Computing and Information Systems

The vulnerability of 3D point cloud analysis to unpredictable rotations poses an open yet challenging problem: orientation-aware 3D domain generalization. Cross-domain robustness and adaptability of 3D representations are crucial but not easily achieved through rotation augmentation. Motivated by the inherent advantages of intricate orientations in enhancing generalizability, we propose an innovative rotation-adaptive domain generalization framework for 3D point cloud analysis. Our approach aims to alleviate orientational shifts by leveraging intricate samples in an iterative learning process. Specifically, we identify the most challenging rotation for each point cloud and construct an intricate orientation set by optimizing intricate orientations. Subsequently, we employ …


Identification And Environmental Impact Of 35 Different Cut Flower Retail Packages In The U.S.A., Mary Kathryn Gillespie May 2025

Identification And Environmental Impact Of 35 Different Cut Flower Retail Packages In The U.S.A., Mary Kathryn Gillespie

All Theses

Cut flowers represent 35-billion dollars of global spending with 10-million dollars per day in the U.S.A; each transaction involving packaging. Across the country, cut flower packaging is inconsistently sized, laminated, colored, and unlikely to be recycled. 35 unique cut flower packages were collected across 16 different marketplaces, representing 88% of top grocery retailers. Measuring the materiality of the predominately unlabeled and inconsistent packaging collected required calorimetry equipment, such as Fourier-transform Infrared Spectroscopy, Differential Scanning Calorimeter, and precision gauges. Results unveil five materials representing the cut flower collection: Oriented Polypropylene (OPP), High-Density Polyethylene (HDPE), Paper, Polyethylene Terephthalate (PET), and Nonwoven Polypropylene …


Simulating Chill: Exploring The Cognitive And Therapeutic Potential Of Cold Vr Environments, Jessica Turner, Piper Hutson, James Hutson May 2025

Simulating Chill: Exploring The Cognitive And Therapeutic Potential Of Cold Vr Environments, Jessica Turner, Piper Hutson, James Hutson

Faculty Scholarship

This study investigates the cognitive and therapeutic potential of immersive virtual reality (VR) environments designed to simulate cold conditions. Through the engagement of participants through multisensory stimuli—including vivid visual representations of the Athabasca Glacier, auditory effects of icy winds, and corresponding haptic feedback—the research evaluates neurological and physiological responses associated with attention, emotional regulation, and stress modulation. Participants experienced virtual scenarios featuring icy winds and snow, activating specific neurological pathways involving the occipital lobe, primary visual cortex, superior colliculus, and insula, thus reinforcing sensory integration. Through predictive coding, the anterior insula and hypothalamus were engaged, prompting thermoregulatory simulations and subconscious …


Elucidating The Mechanisms Of Collagenase H From Hathewaya (Clostridium) Histolytica In Collagen Degradation And Developing A Cross-Linked Platform For Efficient Capture And Release Of Adeno-Associated Virus Serotype 2 (Aav2), Adjoa Otubea Bonsu May 2025

Elucidating The Mechanisms Of Collagenase H From Hathewaya (Clostridium) Histolytica In Collagen Degradation And Developing A Cross-Linked Platform For Efficient Capture And Release Of Adeno-Associated Virus Serotype 2 (Aav2), Adjoa Otubea Bonsu

Graduate Theses and Dissertations

In biological systems, Hathewaya (Clostridium) histolytica secretes collagenases that degrade structural collagen in host tissues and cause tissue necrosis. Despite their detrimental effects, these enzymes have significant therapeutic potential by effectively digesting various collagen subtypes to treat connective tissue disorders. The bacterium produces two homologous collagenases, ColG and ColH, with a catalytic module crucial for hydrolyzing collagen and binding domains, including collagen-binding domains (CBDs) and polycystic kidney disease-like domains (PKDs), for substrate interaction.

Although the crystal structure of the catalytic module of collagenase G (ColG) has been determined, shedding light on its chew-and-digest mechanism, the structure of collagenase H (ColH) …


Capturing The Digital Scene: Applying Routine Activity Theory To Iot Smart Frames, Jordan Bakar May 2025

Capturing The Digital Scene: Applying Routine Activity Theory To Iot Smart Frames, Jordan Bakar

Theses/Capstones/Creative Projects

This project investigates the forensic risks and investigative challenges posed by smart frames, which are WiFi-enabled Internet of Things (IoT) devices used to store, display, and share digital media. These devices often collect and synchronize sensitive media, metadata, and behavioral logs across cloud ecosystems that lack adequate transparency and privacy safeguards. Routine Activity Theory (RAT) provides a criminological framework for examining how the convergence of a motivated offender, a suitable target, and the absence of capable guardianship creates opportunities for misuse and forensic exploitation. Smart frames represent ideal targets because of weak default security configurations, passive data synchronization, and limited …