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Articles 91 - 120 of 1086
Full-Text Articles in Entire DC Network
Cancer Care Terminology In African Languages, Hannah Simba, Miriam Mutebi, Moses Galukande, Yahya Mahamat-Saleh, Elom Aglago, Adamu Addissie, Lidya Genene Abebe, Justina Onwuka
Cancer Care Terminology In African Languages, Hannah Simba, Miriam Mutebi, Moses Galukande, Yahya Mahamat-Saleh, Elom Aglago, Adamu Addissie, Lidya Genene Abebe, Justina Onwuka
General Surgery, East Africa
Importance: Effective communication between patients and health care teams is essential in the health care setting for delivering optimal cancer care and increasing cancer awareness. While the significance of communication in health care is widely acknowledged, the topic is largely understudied within African settings.
Objective: To assess how the medical language of cancer and oncology translates into African languages and what these translations mean within their cultural context.
Design, etting, and participants: In this multinational survey study in Africa, health professionals, community health workers, researchers, and scientists involved in cancer care and research and traditional healers were invited to participate …
More Resilience, More Green Berets: A Quantitative Analysis Of The Effects Of Functional Imagery Training During British Army Commando Training, Emma S. J. Yates
More Resilience, More Green Berets: A Quantitative Analysis Of The Effects Of Functional Imagery Training During British Army Commando Training, Emma S. J. Yates
The Plymouth Student Scientist
This study investigates the low completion rates of the British Army commando training course in 2018-2019, recorded at 20%, following concerns raised by course Directing Staff. It examines the relationship between resilience and performance in military contexts and evaluates whether resilience-building interventions can improve completion rates. To establish how completion rates could be improved, sixty-two candidates from three commando training cohorts were recruited and assigned to either a Functional Imagery Training (FIT) intervention or a control group. Interventions were delivered in week one of training with a booster in week five. FIT, a goal-centred imagery intervention, has previously improved resilience-related …
Nurse Retention Amid Workplace Adversity: Examining Strategies And Outcomes, Horace Smith
Nurse Retention Amid Workplace Adversity: Examining Strategies And Outcomes, Horace Smith
Student Scholarly Projects
Practice Problem: This project aimed to evaluate the effectiveness of nurse retention strategies in enhancing job satisfaction, focusing primarily on Emergency Department (ED) Registered Nurses (RNs). A comprehensive approach was adopted within the ED of a veteran hospital in the Southeast, aimed at promoting staff retention.
PICOT: The PICOT question guiding this project is as follows: In a veteran hospital's Emergency Room (ER) located in the southeast (P), how does the implementation of nurse retention strategies (I) compared to current standards (C) increase their job satisfaction (O) over a period of ten weeks (T)?
Evidence: This project …
East African Refugee Women Seeking Health Care After Government Assistance Ends, Sylivia Chelimo
East African Refugee Women Seeking Health Care After Government Assistance Ends, Sylivia Chelimo
Walden Dissertations and Doctoral Studies
East African refugee women arrive as a vulnerable population in their host country. Before coming to the United States, refugee women may have experienced varying levels of trauma due to civil wars, genocide, sexual assault, deaths of loved ones, terrorist attacks, being taken hostage, and torture in their home country. The purpose of this generic qualitative study was to explore the experiences of refugee women from East African countries seeking health care in the Central United States when government assistance ends. The framework of the behavioral model of health was the guide for examining the experiences of the participant refugee …
Comes In Waves: Clinical Overview Of Vibrio Species, Natalie M. Prosser, Ms
Comes In Waves: Clinical Overview Of Vibrio Species, Natalie M. Prosser, Ms
Student Papers, Posters & Projects
Earth’s oceans, despite their beauty and vast ecosystems, pose numerous threats to marine life and humans living along the coastline. Vibrio species (spp.) is a common species of oceanic bacteria native to coastal and brackish waters. This bacterium is capable of causing various degrees of human disease among different populations. Three clinically significant species of Vibrio include Vibrio vulnificus, Vibrio parahaemolyticus, and Vibrio cholera; all three species share virulence factors, but each are capable of causing varying degrees of vibriosis infections. Vibriosis infections include but are not limited to wound infections, necrotizing fasciitis, and gastroenteritis. In particular, …
Use Of Ultrasound For Identification Of Musculoskeletal Injury In Active Populations, Kathleen Karen Hogan
Use Of Ultrasound For Identification Of Musculoskeletal Injury In Active Populations, Kathleen Karen Hogan
Rehabilitation Sciences Theses & Dissertations
Lower extremity tendinopathies and fasciopathy conditions are prevalent amongst sedentary individuals,1,2 athletes,3,4 elite runners,5,6and military personnel7 and can lead to chronic disability and reduction in quality of life. 8,9 Both tendinopathy and fasciopathy are thought to be mechanical in nature and caused by acute or chronic overloading leading to a disruption in the uniformity of the soft tissue structure. Ultrasound imaging has gained popularity in the last decade among many sports medicine clinicians to gain information regarding tissue structure for musculoskeletal injury (MKSI) management. Ultrasound imaging allows for the evaluation of in-vivo structures and at …
Beyond The Airway, Volume 1, Issue 1, May 2024
Beyond The Airway, Volume 1, Issue 1, May 2024
Beyond the Airway
Table of Contents
3 - Foreword from the Editors-In-Chief
4 - A message from Dr. Eric S. Schwenk
5 - An Interview with Dr. Rishi Kothari
7 - Anesthesia Considerations for Patients on Semaglutide
9 - An Interview with Dr. Jeffrey Mojica
11 - The National Resident Matching Program (NRMP) Match: Is Anesthesiology Becoming More Competitive?
13 - An Interview with Dr. Katherine Dillon and Dr. Matteo Petrera
15 - History of Ketamine in Anesthesia
17 - Editorial Staff
Small Island Risks: Research Reflections For Disaster Anthropologists And Climate Ethnographers, Crystal A. Felima
Small Island Risks: Research Reflections For Disaster Anthropologists And Climate Ethnographers, Crystal A. Felima
UK CARES Faculty Publications
Disasters and climate-related events, including tropical storms, droughts, coastal erosion, and ocean acidification, threaten small island nations. Given the urgency of reducing disaster risks and the effects of climate change on vulnerable populations, this reflection essay pursues three objectives. First, it highlights the role of anthropology, ethnography, and multi-sited research in exploring disaster impacts, climate crises, and public policy in island communities. It then highlights national planning and inter-regional activities to build awareness of various risk reduction efforts by island nations and multi-governmental organizations. This article concludes with discussion prompts to engage researchers, scholars, students, and practitioners studying and working …
The Dry Bloodletting: A History Of The Diagnosis And Treatment Of Posttraumatic Stress Disorders In Military Service Members, Kevin Johnson
The Dry Bloodletting: A History Of The Diagnosis And Treatment Of Posttraumatic Stress Disorders In Military Service Members, Kevin Johnson
Masters Theses, 2020-current
This work is a close look at how veterans of war have been treated medically for ailents of the mind. This work looks closely at the many therapies and pharmaceutical remedies that have been perscribed to veterans with the advent of the field of psycology at the trun of the century. Sources included the Diagnostic and Statistical Manual (DSM), multiple clinical trials and white papers, records from the VA, etc. The reader should walk away with a better understanding of how the path towards healing invisble wounds has been mired with revictimization and controversy.
Psychophysiological Assessment Of Workload Under Varying Degrees Of Demand And Controllability: A Validation Study, K Pietro, H Oh, A Shaver, B Hatfield Facsm
Psychophysiological Assessment Of Workload Under Varying Degrees Of Demand And Controllability: A Validation Study, K Pietro, H Oh, A Shaver, B Hatfield Facsm
International Journal of Exercise Science: Conference Proceedings
A
A Systematic Review Of Mental Health Of Women In Fragile And Humanitarian Settings Of The Eastern Mediterranean Region, Fauziah Rabbani, Aysha Zahidie, Amna Siddiqui, Sanam Shah, Zul Merali, Khalid Saeed, Mohamed Afifi
A Systematic Review Of Mental Health Of Women In Fragile And Humanitarian Settings Of The Eastern Mediterranean Region, Fauziah Rabbani, Aysha Zahidie, Amna Siddiqui, Sanam Shah, Zul Merali, Khalid Saeed, Mohamed Afifi
Brain and Mind Institute
Background: The increasing emergencies and humanitarian challenges have worsened the mental health condition of women in the Eastern Mediterranean Region.
Aim: To assess the prevalence, determinants and interventions to address mental health among women in fragile and humanitarian settings in the Eastern Mediterranean Region.
Methods: Using the Preferred Reporting Items for Systematic Review and Meta-analysis guidelines, we reviewed 59 peer-reviewed published studies (PubMed, IMEMR) and grey literature (WHO/IRIS) from January 2001 to February 2023, focusing on women's mental health in the Eastern Mediterranean Region. We then conducted a descriptive analysis of the sociodemographic characteristics.
Results: Among …
The Use Of Stem Cells In Regenerative Medicine, Catharine Wingle, Ms
The Use Of Stem Cells In Regenerative Medicine, Catharine Wingle, Ms
Student Papers, Posters & Projects
Regenerative Medicine, powered by stem cells, is an emerging field with continuous advancements that impact lives. Stem cells are the precursor to all human cells, and unique characteristics such as the ability to self-renewal and differentiate into other cell types make them versatile in research. Embryonic stem cells (ESCs) have a greater differentiation potential and can increase into almost any cell type, such as bone, skin, or brain. On the contrary, adult stem cells are more restricted in the cell type they will become. In research, various factors can be combined with stem cells, and these cells are genetically alternated …
Natural Products In Food And Agriculture, Stephen O. Duke
Natural Products In Food And Agriculture, Stephen O. Duke
Oxford ICSB
Before the National Center for Natural Products Research (NCNPR) existed, I was Director of a USDA weed management lab. Two of my interests were natural products as herbicides and the chemical ecology of weed/crop interactions (allelopathy). Dr. James McChesney and I had several conversations about his vision for the NCNPR on the University of Mississippi campus. I was very interested in becoming a part of this, as his plan was to have a USDA lab that would study natural products for use in food and agriculture as part of the center. The USDA Agricultural Research Service established the Natural Product …
Hooked On A Feeling: The Importance Of Fostering Emotional Intelligence In Adolescents, Annika Wirkkala
Hooked On A Feeling: The Importance Of Fostering Emotional Intelligence In Adolescents, Annika Wirkkala
Classical Conversations
In the summer of 2023, CNN reported on a 14-year old girl who claimed to have several mental health issues. These included ADHD, depression, autism, and various phobias. After a specialist examined her, however, she was officially diagnosed not with her extensive list of illnesses but with severe anxiety. How did this 14-year old girl become so convinced that she suffered from all of these problems? Social media. Sadly, this girl is not the only victim of social media self-diagnosis. According to the CNN report, “A growing number of teens are turning to social platforms such as Instagram and TikTok …
An Ecological Analysis Of The Elevational Gradient Effect On Mushroom Community Diversity Near Andasibe, Madagascar, Zoe Garver
Independent Study Project (ISP) Collection
The effect of elevational gradients on biodiversity has been widely studied in the field of ecology (Rahbek, 1995). The evidence supports a trend for highest biodiversity at mid latitudes and decreasing biodiversity as elevation increases (Rahbek, 1997; Grytnes, 2003; Hariharan and Buckley, 2022). This effect has primarily been explained by variation of temperatures and resource availability at different elevations. However, the effect that elevation plays on fungal communities is relatively underrepresented in the literature (Dahlberg, 2001). This study analyzes changes in mushroom diversity across an elevational gradient in Mitsinjo Reserve and Analamazaotra National Park found in Madagascar. Using the Braun-Blanquet …
The Inequitable Burden Of Infectious Diseases Among Remote-Living Aboriginal And Torres Strait Islander Australians: A Product Of History, Stephanie L. Enkel, Rebecca Famlonga, Hannah M. M. Thomas, Nina Lansbury, Jonathan R. Carapetis, Glenn Pearson, Asha C. Bowen
The Inequitable Burden Of Infectious Diseases Among Remote-Living Aboriginal And Torres Strait Islander Australians: A Product Of History, Stephanie L. Enkel, Rebecca Famlonga, Hannah M. M. Thomas, Nina Lansbury, Jonathan R. Carapetis, Glenn Pearson, Asha C. Bowen
Journal of the Australian Indigenous HealthInfoNet
Insufficient and poorly maintained housing and plumbing in many remote Australian Indigenous communities in Australia results in reduced capacity to maintain personal hygiene, contributing to infectious disease inequalities. Infections from Streptococcus pyogenes (Strep A) and sequalae are often noted to be the result of contextual poverty; a product of over 230 years of discriminatory practice that has excluded Indigenous people from the basic human rights of healthy, maintained housing afforded to most in the nation. The solutions for eliminating diseases of inequity among Australian Indigenous population are known, their success is historically documented, and yet they are to be comprehensively …
Prevalence, Morbidity, And Mortality Of Men With Sex Chromosome Aneuploidy In The Million Veteran Program Cohort, Shanlee Davis, Craig Teerlink, Julie Lynch, Bryan Gorman, Meghana Pagadala, Aoxing Liu, Matthew Panizzon, Victoria Merritt, Giulio Genovese, Judith Ross, Richard Hauger
Prevalence, Morbidity, And Mortality Of Men With Sex Chromosome Aneuploidy In The Million Veteran Program Cohort, Shanlee Davis, Craig Teerlink, Julie Lynch, Bryan Gorman, Meghana Pagadala, Aoxing Liu, Matthew Panizzon, Victoria Merritt, Giulio Genovese, Judith Ross, Richard Hauger
Department of Pediatrics Faculty Papers
IMPORTANCE: The reported phenotypes of men with 47,XXY and 47,XYY syndromes include tall stature, multisystem comorbidities, and poor health-related quality of life (HRQOL). However, knowledge about these sex chromosome aneuploidy (SCA) conditions has been derived from studies in the less than 15% of patients who are clinically diagnosed and also lack diversity in age and genetic ancestry.
OBJECTIVES: To determine the prevalence of clinically diagnosed and undiagnosed X or Y chromosome aneuploidy among men enrolled in the Million Veteran Program (MVP); to describe military service metrics of men with SCAs; and to compare morbidity and mortality outcomes between men with …
Improving Self-Efficacy In Flight Nurse Practitioners In Preparation For The Role Of The Law Enforcement Tactical Nurse Practitioner, Gregory S. Wamack
Improving Self-Efficacy In Flight Nurse Practitioners In Preparation For The Role Of The Law Enforcement Tactical Nurse Practitioner, Gregory S. Wamack
Doctoral Dissertations and Projects
Current evidence demonstrates that the number of prehospital nurse practitioners working in both civilian and military settings is growing. Additional training beyond the formal nurse practitioner curriculum is necessary to increase the self-efficacy, knowledge, and skills of the nurse practitioner for operational battlefield conditions in far-forward austere and tactical settings. Evidence also demonstrates that the Tactical Combat Casualty Care (TC3) course is the national standard for tactical care and training for all health care providers. The purpose of this evidence-based pilot study was to increase the tactical self-efficacy of the United States based nontactical civilian highly trained and skilled flight …
Practices For Sport-Coach Mentorship: A Historical Case Study For Coaches In Catholic Schools Today, Matt Hoven
Practices For Sport-Coach Mentorship: A Historical Case Study For Coaches In Catholic Schools Today, Matt Hoven
eJournal of Catholic Education in Australasia
Sport-coach mentorship is perhaps the raison d’etre for the inclusion of sports programming within Catholic schools. Coach-educators can have significant and even lifelong impact on student-athlete growth and development. But, how, exactly, should coaches act as mentors in faith-based, educational contexts? Drawing upon an extensive archival and interview research project, this paper presents a historical case study of the sport-coach mentorship of Father David Bauer, csb (1924-88), an educator and exceptional Canadian ice hockey player, coach, manager, and Hockey Hall of Fame inductee. Bauer mentored and spoke out for young sportspeople over many decades. The first part of this paper …
Chronic Respiratory Symptoms Following Deployment-Related Occupational And Environmental Exposures Among Us Veterans, Eric Garshick, Carrie A Redlich, Anna Korpak, Andrew K Timmons, Nicholas L Smith, Karen Nakayama, Coleen P Baird, Paul Ciminera, Farrah Kheradmand, Vincent S Fan, Jaime E Hart, Petros Koutrakis, Ware Kuschner, Octavian Ioachimescu, Michael Jerrett, Phillipe R Montgrain, Susan P Proctor, Emily S Wan, Christine H Wendt, Cherry Wongtrakool, Paul D Blanc
Chronic Respiratory Symptoms Following Deployment-Related Occupational And Environmental Exposures Among Us Veterans, Eric Garshick, Carrie A Redlich, Anna Korpak, Andrew K Timmons, Nicholas L Smith, Karen Nakayama, Coleen P Baird, Paul Ciminera, Farrah Kheradmand, Vincent S Fan, Jaime E Hart, Petros Koutrakis, Ware Kuschner, Octavian Ioachimescu, Michael Jerrett, Phillipe R Montgrain, Susan P Proctor, Emily S Wan, Christine H Wendt, Cherry Wongtrakool, Paul D Blanc
Faculty, Staff and Students Publications
Objectives: Characterise inhalational exposures during deployment to Afghanistan and Southwest Asia and associations with postdeployment respiratory symptoms.
Methods: Participants (n=1960) in this cross-sectional study of US Veterans (Veterans Affairs Cooperative Study 'Service and Health Among Deployed Veterans') completed an interviewer-administered questionnaire regarding 32 deployment exposures, grouped a priori into six categories: burn pit smoke; other combustion sources; engine exhaust; mechanical and desert dusts; toxicants; and military job-related vapours gas, dusts or fumes (VGDF). Responses were scored ordinally (0, 1, 2) according to exposure frequency. Factor analysis supported item reduction and category consolidation yielding 28 exposure items in 5 categories. Generalised …
Low-Level Resource Partitioning Supports Coexistence Among Functionally Redundant Bacteria During Successional Dynamics, Xiaoqian Annie Yu, Craig Mclean, Jan-Hendrik Hehemann, David Angeles-Albores, Fuqing Wu, Artur Muszyński, Christopher H Corzett, Parastoo Azadi, Elizabeth B Kujawinski, Eric J Alm, Martin F Polz
Low-Level Resource Partitioning Supports Coexistence Among Functionally Redundant Bacteria During Successional Dynamics, Xiaoqian Annie Yu, Craig Mclean, Jan-Hendrik Hehemann, David Angeles-Albores, Fuqing Wu, Artur Muszyński, Christopher H Corzett, Parastoo Azadi, Elizabeth B Kujawinski, Eric J Alm, Martin F Polz
Faculty, Staff and Student Publications
Members of microbial communities can substantially overlap in substrate use. However, what enables functionally redundant microorganisms to coassemble or even stably coexist remains poorly understood. Here, we show that during unstable successional dynamics on complex, natural organic matter, functionally redundant bacteria can coexist by partitioning low-concentration substrates even though they compete for one simple, dominant substrate. We allowed ocean microbial communities to self-assemble on leachates of the brown seaweed Fucus vesiculosus and then analyzed the competition among 10 taxonomically diverse isolates representing two distinct stages of the succession. All, but two isolates, exhibited an average of 90% ± 6% pairwise …
Psychological Energy: Early Theorists In The Analytical Tradition, Michael Da
Psychological Energy: Early Theorists In The Analytical Tradition, Michael Da
International Journal of Transpersonal Studies Advance Publication Archive
Since the dawn of Western psychology, theorists have used variations of the term “energy” to describe the dynamic forces at work within the psyche and the soma and the psychotherapeutic processes of change. In the late 19th and early 20th centuries, terms used for psychological energy included “libido,” “psychic energy,” “orgone energy,” “bioenergetics,” and “psycho-energetics.” This paper uses philosophical hermeneutics to compare the major theorists of the late nineteenth and early twentieth century: William James, Pierre Janet, Sigmund Freud, C. G. Jung, Wilhelm Reich, Alexander Lowen, and Roberto Assagioli. The analysis reveals that these theorists generally agreed that psychological energy …
Disease Footprints: Understanding Basic Pathophysiology, Jeff Vasiloff, Md, Mph
Disease Footprints: Understanding Basic Pathophysiology, Jeff Vasiloff, Md, Mph
OHIO Open Faculty Textbooks
Basic pathophysiology explained by Jeffrey Vasiloff, MD, MPH, Associate Clinical Professor, PA Program; Adjunct Professor, PT Program, College of Health Sciences and Professions, Ohio University Dublin Medical Campus; Physician Consultant: Ohio Association of Physician Assistants; Physician Volunteer: Franklin County & Columbus Medical Reserve Corps; Board Certification: Internal Medicine & Diabetes and Endocrinology.
Psychological Energy: Early Theorists In The Analytical Tradition, Michael Da
Psychological Energy: Early Theorists In The Analytical Tradition, Michael Da
International Journal of Transpersonal Studies
Since the dawn of Western psychology, theorists have used variations of the term “energy” to describe the dynamic forces at work within the psyche and the soma and the psychotherapeutic processes of change. In the late 19th and early 20th centuries, terms used for psychological energy included “libido,” “psychic energy,” “orgone energy,” “bioenergetics,” and “psycho-energetics.” This paper uses philosophical hermeneutics to compare the major theorists of the late nineteenth and early twentieth century: William James, Pierre Janet, Sigmund Freud, C. G. Jung, Wilhelm Reich, Alexander Lowen, and Roberto Assagioli. Analysis reveals these theorists generally agreed psychological energy is (a) a …
Tracking The Footsteps Of Burkholderia Mallei: Determination Of The Molecular Differences And Potential Resistance Genes, Dilek Dülger, Seda Eki̇ci̇, Mehmet Demi̇rci̇, Akın Yi̇ği̇n, Orkun Babacan
Tracking The Footsteps Of Burkholderia Mallei: Determination Of The Molecular Differences And Potential Resistance Genes, Dilek Dülger, Seda Eki̇ci̇, Mehmet Demi̇rci̇, Akın Yi̇ği̇n, Orkun Babacan
Turkish Journal of Medical Sciences
Chemical biological radiological nuclear threats are at an important point in the agenda of world health today, as theycan cause mass deaths. B. mallei attracts attention as a potential biological warfare agent due to its features such as multidrug resistance,a rapid transmission mechanism via aerosol, the absence of a complete treatment protocol for the infection it causes, and the absence ofan approved vaccine for protection against the bacteria. B. mallei suspect samples must be studied by experienced personnel in biosafetylevel III laboratories. B mallei is a difficult and troublesome pathogen to diagnose and many unknowns about B. mallei today. Therefore,the …
Experimental Assessment Of Laser Scarecrows For Reducing Avian Damage To Sweet Corn, Sean T. Manz, Kathryn E. Sieving, Rebecca N. Brown, Page E. Klug, Bryan M. Kluever
Experimental Assessment Of Laser Scarecrows For Reducing Avian Damage To Sweet Corn, Sean T. Manz, Kathryn E. Sieving, Rebecca N. Brown, Page E. Klug, Bryan M. Kluever
United States Department of Agriculture Wildlife Services: Staff Publications
Background
Birds damage crops, costing millions of dollars annually, and growers utilize a variety of lethal and nonlethal deterrents in an attempt to reduce crop damage by birds. We experimentally tested laser scarecrows for their effectiveness at reducing sweet corn (Zea mays) damage. We presented 18 captive flocks of free-flying European starlings (Sturnus vulgaris) with fresh sweet corn ears distributed on two plots where laser and control treatments were alternated each day and allowed each flock to forage over 5 days. In 16 trials, fresh sweet corn ears were mounted on wooden sticks distributed from 0 …
Concepts In Animal Parasitology, Chapter 12: Leishmania (Genus) And Leishmaniasis [Protozoa, Trypanosomatidae], Mary Ann Mcdowell, Jennifer Robichaud
Concepts In Animal Parasitology, Chapter 12: Leishmania (Genus) And Leishmaniasis [Protozoa, Trypanosomatidae], Mary Ann Mcdowell, Jennifer Robichaud
Concepts in Animal Parasitology
An overview of the genus Leishmania, protozoan flagellate parasites. Covers the classification, development, life cycles, and effect on human and domestic animal health, including a discussion of the human disease leishmaniasis as well as animal models and immunology.
Chapter 12 in Concepts in Animal Parasitology on the genus Leishmania and leishmaniasis by Mary Ann McDowell and Jennifer Robichaud. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap012
Global Deaf And Disability-Led Partnerships For Accessible Emergency Response And Humanitarian Action, Alina A. Engelman, Joe Booze, Alexia Izquierdo
Global Deaf And Disability-Led Partnerships For Accessible Emergency Response And Humanitarian Action, Alina A. Engelman, Joe Booze, Alexia Izquierdo
The Journal of Sociology & Social Welfare
Disability-serving non-profit, non-governmental organizations (NGOs) play a critical role in fostering care networks and supporting humanitarian action for disabled people before and during emergencies, particularly in the absence of targeted philanthropic and governmental support. However, relatively few NGOs serving disabled people are led or operated by people with disabilities, especially by disabled women. This analysis, based on survey and interview data with leadership, explores the impact of two disability-led operations. Findings have profound implications for how social work practice can center disability justice both in preparing for and responding to emergencies. This paper assesses the needs and impact of two …
Elaboration Of Diquinanes To Access Trifunctional Angular Triquinanes And Designed Dna Polymerase Α Inhibitors, Spencer M. Webber
Elaboration Of Diquinanes To Access Trifunctional Angular Triquinanes And Designed Dna Polymerase Α Inhibitors, Spencer M. Webber
University of the Pacific Theses and Dissertations
Natural products are of great significance to the pharmaceutical industry in the development of new drugs. Diquinane or bicyclo[3.3.0]octane is a conspicuous structural unit existing in the carbo-frameworks of a wide range of natural products such as alkaloids and terpenoids. These diquinane-containing molecules not only exhibit intriguing architectures, but also showcase a broad spectrum of significant bioactivities, which draw widespread attention from the global synthetic community. A more specific group of compounds containing a diquinane moiety with one extra 5-membered ring are called the angular triquinanes.In this work, we have developed a general synthetic scheme to the angular triquinanes. We …
Generation Of Protease Inhibitory Antibodies By Functional In Vivo Selection, Ki Baek Lee, Xin Ge
Generation Of Protease Inhibitory Antibodies By Functional In Vivo Selection, Ki Baek Lee, Xin Ge
Faculty, Staff and Student Publications
Targeting dysregulated protease expression and/or abnormal substrate proteolysis, highly selective inhibition of pathogenic proteases by monoclonal antibodies (mAbs) presents an attractive therapeutic approach for the treatment of diseases including cancer. Herein, we report a functional selection method for protease inhibitory mAbs by periplasmic co-expression of three recombinant proteins-a protease of interest, an antibody Fab library, and a modified β-lactamase TEM-1. We validate this approach by isolation of highly selective and potent mAbs inhibiting human matrix metalloproteinase 9 (MMP9).