Digital Commons Network^™

Production And Characterization Of Monoclonal Antibodies Against Botulinum Toxin Produced In Nicotiana Benthamiana, Kornchanok Sangprasat

Chulalongkorn University Theses and Dissertations (Chula ETD)

Botulism is an uncommon but serious neurological condition caused by the botulinum toxin produced by the gram-positive bacterium named Clostridium botulinum. Common symptoms of botulism include muscle cramps, nausea, vomiting, diarrhea, difficulty swallowing, respiratory failure, muscle weakness, and potentially death. Currently, two types of antitoxin are used: equine-derived heptavalent antitoxin and human-derived immunoglobulin (BabyBIG®). However, treatment with heptavalent antitoxin may lead to hypersensitivity reactions, while BabyBIG®, which is produced in low yield, is used only for children. This research focuses on developing three anti-BoNT monoclonal antibodies (mAbs), 1B18, C25, and M2, which will be produced using Nicotiana benthamiana as a …

The Physiological And Performance Consequences Of The Australian Special Forces Selection Course, Angela Uphill

Theses: Doctorates and Masters

Special Forces (SF) soldiers are the most elite element of military forces, who have undergone rigorous training in order to prepare them for a wide array of specialised missions. In Australia, entry into the SF is determined through the highly competitive SF Selection Course (SF-SC), which is a gruelling program involving extreme physical demands, psychological stress, and restricted access to sleep and nutrition. The stressors involved in arduous military training events such as the SF-SC can result in significant losses of fat mass and lean mass, disruption to hormonal homeostasis, and significant decreases in neuromuscular capacity, which can potentially increase …

Bridging Biomedical Research With Aerospace Engineering In The Lab Of Tomorrow, Christine Walck

Publications

“My goal with this lab is to take biomedical research and tie it into a school that is grounded in aerospace and aeronautical engineering,” says Assistant Professor of Mechanical Engineering at Embry-Riddle Aeronautical University’s Daytona Beach Campus, Christine Walck. “How do I make that connection? That’s the question I’ve been working on for the past couple of years with Vicon.”

How 'Strong' Is The British Army?, Peter Ladlow, C. Suffield, J. P. Greeves, Paul Comfort, J. Hughes, R. P. Cassidy, A. N. Bennett, R. J. Coppack

Research outputs 2022 to 2026

One of six research themes outlined in the 2021 Strategic Delivery Plan for UK Defence Medical Services (DMS) Research 2021–2026 is ‘preventing and treating musculoskeletal injury (MSKI)’.1 The research priorities identified include: ‘injury prevention and prehabilitation’, ‘lower-limb injury’, ‘shortened time to return-to-service’ and ‘physical comorbidity’. The strategic development plan also identified a need for research investigating ‘factors affecting deployment suitability and how they can be assessed and mitigated’. . . .

Massive Transfusion And Shock Index, Kasey House

MSN Capstone Projects

Hemorrhagic shock is one of the leading causes of preventable death in military trauma patients. Literature shows that pre-hospital transfusions of blood products within the combat environment have shown to have a greater likelihood of survival. This has produced a challenge in the pre-hospital setting to have a standardized method of predicting the patient’s need for a massive transfusion. In the last few years, the development of a Massive Transfusion Protocol (MTP) has become the standard to quickly deliver blood products to actively bleeding patients. Every minute waiting to administer blood products increases mortality by 5%.

While initiating an MTP …

Neural Damage Following Francisella Tularensis Infection, Anahis Tena

Open Access Theses & Dissertations

This dissertation investigates the impact of Francisella tularensis infection on the brain, focusing on its anatomical localization, effects on synaptic health, and behavioral and cognitive consequences in mice. Employing a combination of fluorescent tagging, confocal and light sheet microscopy, the study first maps bacterial foci within the brain, anticipating a concentration in the limbic system, particularly the hippocampus. Subsequently, it examines synaptic function post-infection using calcium imaging in various neuronal cultures, expecting a decrease in calcium signaling indicative of synaptic impairment. Finally, behavioral assays like the forced swim test, object recognition test, and Morris Water Maze assess the cognitive and …

The Social Determinants Of Health And Genocide: Towards A Public Health Integrated Framework Of Genocide And Mass Violence, Sian Persad, Cheng Xu

Genocide Studies and Prevention: An International Journal

This paper makes a normative argument about transformations of public health as a necessary condition required in any transitional justice process. We seek to bridge the gap between the fields of genocide and public health to understand the recursive relationship between genocide and the social determinants of health. We show that structures and institutions established during genocide create enduring impacts on the public health outcomes of victim and survivor groups even after the ousting of the original perpetrators. Our comparative analysis of the Rwandan Genocide and the colonial genocide of Indigenous communities in Canada surveys the available public health literature …

Stress Response To Winter Warfare Training: Potential Impact Of Location, Lauren M. Visconti, Andrea C. Givens, Lorraine P. Turcotte, Laura Arrington, Karen R. Kelly

International Journal of Exercise Science: Conference Proceedings

Winter Warfare Training (WWT) is a critical component of military training to prepare individuals to move effectively in harsh conditions. Moving through snow and heavy terrain increases overall stress to the entire human system. PURPOSE: The purpose of this effort was to quantify the stress response during WWT to determine the level of physiological adaptation to extreme environments. METHODS: Mountain and mobility operators (age: 31.5±1.4 years; height: 71.1±0.5 inches; weight: 192.5±6.6 lbs.; body fat percentage: 18.0±5.0%) were recruited for this effort. Participants engaged in baseline laboratory metrics at their home station located in Colorado (CO) prior to WWT for one …

Progressive Neurochemical, Neuroinflammatory And Cognitive Deficits In An Experimental Model Of Gulf War Illness, Hannah Elizabeth Burzynski

Theses and Dissertations

Gulf War Illness (GWI) is a multi-symptom illness that presents with cognitive disturbances and immune dysregulation and continues to affect over 25% of Gulf War veterans. While soldiers were exposed to several hazards in the Gulf, the prophylactic use of the acetylcholinesterase inhibitor, pyridostigmine bromide (PB) and war-related stress have been identified as chief factors in GWI pathology. As both PB and stress alter acetylcholine (ACh), a critical mediator of cognition and inflammation, the focus of my dissertation work was investigating the lasting effects of PB and stress on peripheral and central cholinergic signaling. Specifically, I assessed hippocampal-dependent learning and …

Volume 16, Issue 2

Medical Muse

No abstract provided.

The African American Dream Deferred: Exploring The Relationship Between The “American Dream” And The Black American Millennial Reality, Simonleigh P. Miller

Seton Hall University Dissertations and Theses (ETDs)

The purpose of this qualitative study is to highlight and bring understanding to the lived experiences of Black American millennials. This study was conducted from the constructivist and critical research paradigms and utilized Reflexive Thematic Analysis methods to analyze qualitative data. The study places specific focus on Black or African American millennials’ associated thoughts and feelings regarding their current reality and positionality within the American context, and its relation to the idealized reality of the American Dream. The influence of the American Dream on the African American millennial reality was explored to gain a better understanding of how, or if …

Pilot Testing Of A Non-Gaming Cognitive Battery In Expert Esports Athletes, Allison J. Brager, Patrick Belling, Jason Sada, Jeffrey Osgood, Bradley Fawver, Michael Dretsch

Journal for Sports Neuroscience

Introduction: The esports industry is rapidly expanding, making it imperative to identify common data elements of expert gamers for the purposes of performance optimization and enhancement. We aimed to measure cognitive performance in a convenient sample of expert esports athletes, as well as to determine if cognitive performance of these individuals could be further enhanced through a novel non-gaming neurocognitive test battery.

Methods: Elite esports athletes (n = 5) participated in a four-day cognitive and strength & conditioning program at the Sports Academy (Thousand Oaks, CA). Cognitive performance was assessed through five tasks of increasing cognitive load. Baseline …

Perceptions, Practices, And Barriers Of Athletic Trainers In The Military Setting Using Patient-Reported Outcomes In Practice, Nicole M. Lee, Justin P. Young, Lindsey E. Eberman, Eric Post, Kenneth E. Games

Internet Journal of Allied Health Sciences and Practice

Purpose: The majority of athletic trainers (ATs) recognize the importance of patient-reported outcomes (PROs) in clinical practice but encounter unique barriers that limit their implementation. There are no studies that have investigated PROs in the military setting. The purpose of this study was to explore the perceptions, practices, and barriers to implementing PROs in the military setting. Methods: We used a cross-sectional, web-based survey design. Emails were sent to 365 potential participants and 67 were eligible to participate (response rate=18.4%, years practicing in military setting=5.9 ± 5.8years). Participants were invited to complete a web-based survey regarding the uses, benefits, and …

Neuroendocrine Responses To Cold Pressor Stimuli In Midshipmen Participating In The Naval Special Warfare Screener., V J. Patel, B J. Martin, M Wright, A Susmarski Facsm, M Lovalekar, M E. Beckner, A K. Ledford, S D. Flanagan, B C. Nindl Facsm

International Journal of Exercise Science: Conference Proceedings

poster

An International Delphi Consensus Statement On Metabolic Dysfunction-Associated Fatty Liver Disease And Risk Of Chronic Kidney Disease, Dan-Qin Sun, Giovanni Targher, Christopher D Byrne, David C Wheeler, Vincent Wai-Sun Wong, Jian-Gao Fan, Herbert Tilg, Wei-Jie Yuan, Christoph Wanner, Xin Gao, Michelle T Long, Mehmet Kanbay, Mindie H Nguyen, Sankar D Navaneethan, Yusuf Yilmaz, Yuli Huang, Rino A Gani, Pierluigi Marzuillo, Jérôme Boursier, Huijie Zhang, Chan-Young Jung, Jin Chai, Luca Valenti, George Papatheodoridis, Giovanni Musso, Yu-Jun Wong, Mohamed El-Kassas, Nahum Méndez-Sánchez, Silvia Sookoian, Michael Pavlides, Ajay Duseja, Adriaan G Holleboom, Junping Shi, Wah-Kheong Chan, Yasser Fouad, Junwei Yang, Sombat Treeprasertsuk, Helena Cortez-Pinto, Masahide Hamaguchi, Manuel Romero-Gomez, Mamun Al Mahtab, Ponsiano Ocama, Atsushi Nakajima, Chunsun Dai, Mohammed Eslam, Lai Wei, Jacob George, Ming-Hua Zheng

Faculty, Staff and Students Publications

BACKGROUND: With the rising global prevalence of fatty liver disease related to metabolic dysfunction, the association of this common liver condition with chronic kidney disease (CKD) has become increasingly evident. In 2020, the more inclusive term metabolic dysfunction-associated fatty liver disease (MAFLD) was proposed to replace the term non-alcoholic fatty liver disease (NAFLD). The observed association between MAFLD and CKD and our understanding that CKD can be a consequence of underlying metabolic dysfunction support the notion that individuals with MAFLD are at higher risk of having and developing CKD compared with those without MAFLD. However, to date, there is no …

Terrorist Attacks Against Sports Venues: Emerging Trends And Characteristics Spanning 50 Years, Grace R Rahman, Gregory N Jasani, Stephen Y Liang

2020-Current year OA Pubs

INTRODUCTION: Sports venues foster community and support local economies. Due to their capacity to host hundreds to thousands of spectators, sports venues are vulnerable to becoming targets of terrorism. Types of venues targeted, regional trends, and methods of attack employed world-wide have not been well-described.

METHODS: A search of the Global Terrorism Database (GTD) was conducted from 1970 through the end of 2019. Pre-coded variables for target type "business" and target subtype "entertainment/cultural/stadium/casino" were used to identify attacks involving venues where sports events might be viewed by spectators as part of an audience. Sports venues were specifically identified using the …

Acquiring Manual Flying Skills In A Virtual Reality Flight Simulator, Wiestse D. Ledegang, Erik Van Der Burg, Ivo V. Stuldreher, Mark M. J. Houben, Eric L. Groen, Danny Van Der Horst, Erik A. M. Starmans, Guido Almekinders

International Symposium on Aviation Psychology - 2023

In this study, we explored the possibility of objectively assessing the progress in manual flying skills by student pilots using Virtual Reality (VR). Using a VR flight simulator of the Pilatus PC-7 training aircraft, fifteen participants without flying experience practiced basic flight maneuvers based on self-study and without receiving feedback. Relevant flight performance measures were normalized and a learning curve was fitted, representing learning speed and end-level. During some runs an N-back task was included as a secondary task to quantify the participants’ cognitive capacity. Interestingly, performance on the N-back was not a good predictor of someone’s learning curve. The …

Experimental Evaluation Of Cloud-Based Synchronous Mult-Pilot Multiuav Mission Plan Generation In A Mum-T Environment, Siegfried Maier, Axel Schulte

International Symposium on Aviation Psychology - 2023

In this study, we compares two approaches for creating mission plans in mannedunmanned teams (MUM-T). In traditional military MUM-T air operations, one human pilot commands multiple UAVs in package-based planning. In situations where multiple teams are working together, it could be helpful to provide all human pilots with equal and simultaneous access to all available UAVs and remove hierarchical boundaries at the team level through a cloud-based approach. The experimental study involved 10 teams of 2 participants each to compare the two approaches. After each mission, participants completed a NASA-TLX questionnaire to assess their workload and rated their perceptions of …

Interface Design For Collaboration With Semi-Autonomous Agents From An Airborne Aircraft, Maj John A. Steveneson, John Mcguirl, Michael E. Miller

International Symposium on Aviation Psychology - 2023

The development of intelligent standoff weapons presents several challenges to support effective human-machine teaming. A key issue involves leveraging the weapon’s ability to sense and react to new threats and engage targets of opportunity in flight while balancing human fiduciary control. This research sought to develop a methodology to determine information requirements of weapons operators to support high levels of teaming during a mission. Baselining a population of operators and conducting cognitive task analyses of system experts from among Air Force Weapons School graduates helped to understand the cognitive requirements and teaming practices of currently fielded systems and elicit goals …

Fostering Resilience In Children Of United States Navy Seals Using A Social Media Platform, Riley Walker

Doctor of Nursing Practice Final Manuscripts

Background: Having resilience helps children overcome, cope, and manage stressors that they encounter throughout life and provides intrinsically protective factors to help a child thrive in the face of adversity.

Local problem: Children of United States Navy Sea, Air, and Land Operators (SEALs) face consistent stress as their parent is away from home more than 240 days per year doing high-risk training exercises.

Methods: Resilience education to mothers of children whose fathers are United States Navy SEALs delivered virtually on a social media platform. Pre- and post- intervention surveys using the Likert scale were conducted to measure the mothers’ understanding …

Utilizing Fram And Digital Materiel Management To Evaluate System Resilience And Inform Design Decisions, Hannah Rennich, Michael E. Miller, John M. Mcguirl

International Symposium on Aviation Psychology - 2023

As technology upgrades become more complex and introduce sources of performance variability into the system, human factors engineers must identify and mitigate the risks involved. As opposed to more traditional methods like Human Factors Failure Mode and Effects (HF-FMEA), this research explored the use of the Functional Resonance Analysis Method (FRAM) and Model-Based Systems Engineering (MBSE) activity diagrams to better understand how variability of human behavior in complex socio-technical systems affect overall performance and how redesign may address performance shortfalls. FRAM analysis was conducted to detect potential failures and deviations. MBSE activity diagrams were then developed to decompose the actions …

Innovator - Spring 2023

Innovator

03 - The President’s Column

06 - Time Machine: Fabric of the Heart

10 - The Nexus: News at Jefferson

20 - Student to #Philebrity: Influenced by Jefferson

24 - The Light Fantastic

30 - We Are One Jefferson

34 - Question & Innovate

36 - Reimagine

40 - Ram Roundup

44 - Class Notes

56 - In Memory

58 - Trivia

A Novel Neuroinvasive Infection Modality For Francisella Tularensis Elicits Neuroinflammation Resulting In Cellular Damage, Mireya Griselle Ramos-Muniz

Open Access Theses & Dissertations

Francisella tularensis (Ft.) is a gram-negative coccobacillus bacterium that causes the zoonotic disease tularemia in humans. Ft. causes the most severe, often fatal, form of the disease through inhalation. However, Ft. is most commonly transmitted through direct contact with infected animal carcasses such as rodents and rabbits, consumption of contaminated food or water, or through arthropod bites, particularly ticks. Due to its extremely low infectious dose, high mortality rate, and potential use as a biological warfare agent, Ft. is classified by the CDC as a "Tier 1 select agent". Ft. infection triggers an overactive inflammatory response, termed a "cytokine storm", …

From “Cowardice” To “Shellshock”: The Definition And Treatment Of Mental Health In The United States Marine Corps During The Age Of The Great War, Itzel Marquez

Theses and Dissertations

The aim of my master’s thesis is to study how the United States’ Marine Corps recognized, defined, and treated mental health issues during the Great War and how this translated into the treatment of Marines by their peers and commanding officers. Similar to other countries that fought in the Great War, also referred to as World War I, the United States witnessed intense discussions about the psychological effects of war. The question of whether and how modern warfare affected troops’ mental health was addressed by all branches of the United States’ military. Yet, the issue of mental health in the …

Design And Synthesis Of Peripherally Selective Endocannabinoid Enzyme Inhibitors For Ocular Indications, Kezia Reji Thomas

Senior Honors Theses

Peripherally selective compounds have been found to stimulate endocannabinoid receptor activity, which has been observed to have positive physiological effects such as ocular wound healing and inflammation control. The activation of the cannabinoid 1 receptor via binding of the endogenous ligands, anandamide and 2-arachidonoylglycerol, has been indicated to elicit these effects. Both ligands are controlled by two hydrolase enzymes, fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), which can be targeted for therapeutic inhibition. Sulfonamide derivatives of JZL195 containing carbamate functionalities in the southern region of the inhibitor compounds were produced using novel carbamate exchange reactions. Polar functionalities were …

“Back To The Jungle”: Investigating Rats, Grass, Scrub Typhus, And Plantations In Malaya, 1924–1974, Jack Greatrex

Research Collection College of Integrative Studies

In this article, I examine epidemiological research into scrub typhus in British Malaya between 1924 and 1974. Interwar research, I show, explained the incidence of the disease through conjunctions of rats, mites, plantations, lalang grass, and “jungle.” In the process, interwar researchers bridged a novel scientific vocabulary centering on disease “reservoirs” with older suspicions of plantations enabling “pests,” as well as with a later, explicitly ecological understanding of infectious disease. In exploring this history I thereby help to re-historicize the emergence of ecological notions of disease reservoirs, whilst also pushing at the limit-points of influential notions of “tropicality.”

Musculoskeletal Injury Concealment In The Reserve Officers’ Training Corps, Joshua D. Wooldridge

UNLV Theses, Dissertations, Professional Papers, and Capstones

INTRODUCTION: Among service members, musculoskeletal injuries threaten military readiness and place a substantial burden on medical and financial resources. While musculoskeletal injuries (MSKIs) are a leading threat to military readiness, service members’ unwillingness to seek care constrains current prevention and surveillance efforts. A growing body of evidence shows US service members conceal a large proportion of injuries, especially in training environments. The Reserve Officers’ Training Corps is a critical training environment for future US military commissioned officers. Reserve Officers’ Training Corps (ROTC) is the largest commissioning source of new officers for the US military. ROTC cadets are college students concurrently …

Development Of Guidelines For Early Implementation Of Regional Anesthesia In United States Personnel With Peripheral Injuries, Matthew Baker

Doctor of Nursing Practice Scholarly Projects

Dating back to 3200 BC, military personnel routinely experience peripheral extremity wounds during combat. Traditionally, military anesthesia providers utilized general anesthesia and opioids to treat acute pain in the combat setting. Opioids can cause adverse effects such as respiratory depression, delirium, hemodynamic instability, nausea & vomiting, and addiction, which causes delays in care and requires more resources. Regional anesthesia is gaining favor during military operations due to its safety profile and effectiveness in controlling acute pain. Regional anesthesia is safer and more effective than opioids in the trauma/combat setting. Guidelines were provided based on current evidence in the literature and …

Inhibiting Effects Of Methyllycaconitine (Mla) On Pnu-282987 Induced Neurogenesis In Blast-Exposed Mouse Retinas, Nastia Zhiyew Chan

Honors Theses

Irreversible vision loss can be caused by retinal damage, disease, or aging. In recent years, the prevalence of ocular damage due to blast trauma has been increasing due to the modernization of warfare. Adult mammalian retinal neurons were previously thought to lack the capacity for regeneration to reverse vision loss, which deemed the effects of many ocular damages permanent. However, recent studies from this lab have shown that PNU-282987, an agonist to the alpha 7 subtype of neural nicotinic acetylcholine receptors, will result in neural regeneration in adult mammalian cells. For this research project, I will be using Methyllycaconitine (MLA), …

Ua12/2/2 Talisman: Surreal Issue No. 14, Wku Student Affairs

WKU Administration Documents

Spring 2023 Talisman:

• Broekema, Gabi. Surrealism
• Hunter, Leah. Surreal
• Cox, Samantha. Surrealism
• Plescia, Audrey. Horoscopes
• Booth, Pandora. Dreamscapes
• Ousley, Rachael. Body & Soul – Yoga, Susan Tutino
• Coles, Jack. Tool for the Future – Artificial Intelligence
• Sandlin, Ellie. Altered Minds – Drug Experimentation
• Neidlinger, Heather. Little Dipper
• White, Peyton. Pure Adrenaline – Rodeo, Skateboarding, Boxing, Rock Climbing
• Plescia, Audrey. The Hill is Haunted
• Richer, Cailyn. Threads of Expression – Fashion
• Jefferson, Reginald. Momentum
• Bruck, Lasikka. At Death’s Door – Yenni Gonzalez, Zoe Avery, Hannah Smith
• Meyers, Jeffrey. Voice in Movement – Theatre & Dance, National Dance Education Association
• Surreal Playlist