Average Performance And Performance Variability On A Brief Functional Fine Motor Test Reflect Distinct Behavioral Constructs In Aging, Chung-Fu Sun, Kyle B. Tomlin, Jennapher Lingo Vangilder, Andrew Hooyman, Alexandra M. Reed, Jessica L. Trevino, Sydney Y. Schaefer

Physical Therapy Faculty Articles and Research

Prior work in older adults has developed a brief functional fine motor test, which involves repeated timed trials of an upper-limb task. Performance has been associated with global and domain-specific neuropsychological tests as well as putative markers of Alzheimer’s disease when scored using variability in trial time; however, the extent to which task performance depends on motor ability has not been established nor quantified. This retrospective study examined whether mean trial time and trial time variability (measured as intrasubject standard deviation in trial time) were differentially associated with standard assessments of motor and cognitive function. Forty-eight older adults with no …

Construction And Application Of Clinical Evidence Framework For Brain-Computer Interface, Wenxiu Qi, Cheng Zhou

Bulletin of Chinese Academy of Sciences (Chinese Version)

Brain-computer interface systems are emerging neurotechnologies that are gradually moving from laboratory research toward clinical application. However, their inherent features, including small sample sizes, heterogeneous technical pathways, and rapid product iteration, make it difficult to integrate safety and efficacy data across studies or to conduct meaningful cross-study comparisons. These challenges not only hinder the cumulative development of evidence in evidence-based medicine, but also complicate the assessment of clinical access and regulatory review. In addition, subjective evidence, such as patient experience, remains insufficiently captured in existing evaluation frameworks. It is therefore necessary to examine the structure of evidence for brain-computer interface …

Osteoblast-Derived Nerve Growth Factor Supports Skeletal Adaptation To Mechanical Load And The Osteoanabolic Effect Of Gambogic Amide In Mice, Ibtesam Rajpar, Eri Mclaughlin, Gabriella Fioravanti, Nicholas Ruggiero, Nohael Cherian, Liliana Minichiello, Ryan E. Tomlinson

Department of Orthopaedic Surgery Faculty Papers

In adult mice, new bone accrual following mechanical load is mediated by the neurotrophin nerve growth factor (NGF) that is expressed by osteoblasts on the bone surface. NGF can bind to its high affinity receptor, neurotrophic tyrosine kinase receptor type 1 (TrkA), on peripheral sensory nerves resident in bone and support new bone formation. However, the osteoanabolic therapeutic potential of NGF-TrkA signaling to repair bone is limited due to the long-lasting thermal and mechanical hyperalgesia induced by administration of NGF in mice and humans. Here, we investigated whether 1) mature osteoblasts are the primary source of NGF required for bone …

Transportability Of An Artificial Intelligence Electrocardiography Model For Structural Heart Disease: External Validation And Recalibration Of Echonext-Mini In Mimic-Iv, Emmanuel Otabor, Abdulraheem Hassan, Ayoyimika Okunlola, Justin Lam, Laith Alomari, Michael Hamilton

Einstein Health Papers

AIMS: Structural heart disease is often underdiagnosed, and echocardiography is limited by access and referral thresholds. Artificial intelligence electrocardiography (AI-ECG) may identify echocardiographically defined structural heart disease. EchoNext-Mini is a released AI-ECG model, accompanied by a benchmark dataset, that detects a composite structural heart disease outcome and component conditions from 12-lead electrocardiogram waveforms together with age, sex, and electrocardiographic measurements. We assessed its transportability and recalibration.

METHODS AND RESULTS: We linked electrocardiograms from MIMIC-IV to subsequent transthoracic echocardiograms, including adults whose electrocardiogram preceded an eligible echocardiogram within one year, one per patient. Labels were mapped to structured echocardiographic fields using …

Evaluation Of Radial Artery Anatomy With Various Anatomical Variants In Patients Undergoing Transradial Q1 Catheterization, Nisarg Desai, Sharadkumar Jain, Kunal Parwani, Pooja Vyas, Yaqub Sidatar

Journal of the Saudi Heart Association

Objectives: This study aimed to determine the incidence of radial artery anomalies in a large cohort of patients undergoing TRA and to evaluate their specific impact as predictors of procedural failure and access site complications.                                                                                  

  Methods: This prospective, observational, single-center study enrolled 1000 consecutive patients undergoing coronary angiography or intervention via TRA between 2022 and 2024. Radial artery anatomy was assessed using retrograde radial arteriography immediately following sheath insertion. Anatomical variants were categorized into high bifurcation (origin proximal to the cubital fossa), Radial artery loops (full 360-degree curvature), Tortuosity (curve of more than 45 degrees in the vessel), Narrow calliber, …

"Re-Evaluation Of Radial Artery Anatomy With Anatomical Variants In Patients Undergoing Transradial Catheterization, Eman Aslam, Eman Zahra, Maryam Amjad

Journal of the Saudi Heart Association

No abstract provided.

Prenatal Cannabis Exposure Is Associated With Occipitotemporal Brain Surface Area In Neonates, Alexander J. Dufford, Sun Hyung Kim, Martin Styner, Xinyi Shen, Erika Iisa, Marilyn A. Huestis, Peter Fried, Christine Conageski, Jocelyn E. Phipers, Cristina Sempio, Jost Klawitter, Pilyoung Kim, Tessa L. Crume

Institute of Emerging Health Professions Faculty Papers

IMPORTANCE: Prenatal cannabis use has been associated with neurodevelopmental consequences for the offspring beginning in childhood; however, it is unclear if neonatal brain structural morphometry is impacted shortly after birth.

OBJECTIVE: We examined differences in regional surface morphometry among neonates exposed to chronic in utero cannabis compared to unexposed neonates.

DESIGN: The Moms Helping Moms study is a prospective pre-birth cohort selected based on chronic prenatal cannabis use and an unexposed control group. Exclusion criteria included alcohol, tobacco, or other substance use. Participants included in this analysis included 18 mother-neonate pairs with prenatal cannabis exposure and 21 unexposed pairs. Chronic …

Early-Onset Progressive Encephalopathy With Brain Oedema And/Or Leukoencephalopathy 1: Report Of Three Siblings, Fatema Al-Amrani, Fathiya Al-Murshedi, Khalid Al-Thihli, Eiman Al-Ajmi, Buthaina Al-Musalhi, Asmaa Al Shehhi, Amna Al Futaisi

Sultan Qaboos University Medical Journal

NAXE encephalopathy, also known as early-onset progressive encephalopathy with brain oedema and/or leukoencephalopathy-1 (PEBEL-1), is a rare and often lethal autosomal recessive mitochondrial disorder. Typical presentation includes psychomotor regression, ataxia, respiratory insufficiency and seizures triggered by febrile illness. This report describes three siblings from a consanguineous family who presented to a tertiary care hospital in Muscat, Oman, in 2022 and were found to have a homozygous pathogenic variant in the NAXE: NM_144772.2:c.827del, p.(Pro276Hisfs*43). Beyond the classic neuroradiological and clinical features of PEBEL-1, these patients exhibited novel phenotypic manifestations, including axonal polyneuropathy, Bull's eye maculopathy and a late-onset presentation of …

Faktor-Faktor Yang Berhubungan Dengan Kejadian Prediabetes Pada Perawat Di Rumah Sakit X Tahun 2025, Putri Nurhaliza, Chandrayani Simanjorang, Agung Raharjo

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Prediabetes dapat berkembang menjadi diabetes melitus dan meningkatkan risiko penyakit kardiovaskular. Selain itu, beban ekonomi juga meningkat akibat tingginya biaya pelayanan kesehatan dan penurunan produktivitas kerja. Salah satu kelompok berisiko prediabetes adalah perawat karena karakteristik pekerjaannya, seperti penerapan sistem kerja sif serta tingginya beban dan tekanan kerja yang dapat memicu stres. Penelitian ini dilakukan untuk mengidentifikasi faktor-faktor yang berhubungan dengan kejadian prediabetes pada perawat di Rumah Sakit X pada tahun 2025. Desain studi yang digunakan adalah cross-sectional dengan sumber data primer yang dikumpulkan melalui pengisian kuesioner dan data sekunder yang diperoleh dari laporan hasil medical check-up tahun 2025. Populasi dalam …

Risk Factors Associated With Moderate And Severe Traumatic Brain Injury Mortality In Admitted Older Adults: A Retrospective, Single-Center Study At A Level Ii Trauma Center., Michael Sawyers, Katherine Graham, John Elliott, Jeff Hubartt

Trauma and Acute Care Articles

Purpose: Approximately one in four adults aged ≥65 years experiences a fall each year, and over one-third of these events require medical care. Older adults are at higher risk of complications because of comorbidities. Most prior studies have focused on incidence rather than outcomes, and few have evaluated the association between age and traumatic brain injury (TBI) mortality. This study assessed risk factors and risk-adjusted mortality and morbidity among older adults with moderate or severe TBI.

Methods: We conducted a retrospective review of data from a single-center trauma registry. Inclusion criteria were age ≥65 years, admission ≥3 days (2019-2024), Abbreviated …

Brittle Bone Disorders Consortium Of The Rare Disease Clinical Research Network, Bettina Willie

Funded Research Records

No abstract provided.

Novice Nurses’ Perceptions Of Caring With Empathy In An Acute Care Hospital In The Northeastern United States: A Transcendental Phenomenological Study, Haley Zurcher

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to understand the essence of the experience of empathy among novice nurses in an acute care facility in the Northeast United States. The Central Research Question (CRQ) for this study was: What was the perceived experience/understanding of empathy by novice nurses working in acute care settings in northeastern Pennsylvania, United States? The study was guided by Bandura’s (1977) self-efficacy theory to examine how confidence, environmental influences, and personal beliefs shaped the development and expression of empathy in early nursing practice. The study was conducted at a large acute care hospital. The sample …

Nurse-Led Remote Patient Monitoring In Outpatient Heart Failure, Jackline Ukadike

Walden Dissertations and Doctoral Studies

Chronic heart failure (HF) remains a leading cause of avoidable hospital readmissions and emergency department visits due to delayed recognition of early symptom exacerbation between routine outpatient encounters. This doctoral quality improvement project evaluated whether the implementation of an evidence-based, nurse-led remote patient monitoring (RPM) standard operating procedure (SOP) improved early identification of symptom exacerbation compared to standard episodic care among adult heart failure patients (NYHA Class II–III) in an outpatient primary care setting over a 10-week period. Guided by the Plan-Do-Study-Act (PDSA) framework, an evidence-based clinical practice guideline (CPG) and escalation protocol were developed and appraised by a 3-member …

Staff Education On Teaching Evidence-Based Chronic Pain Management, Valdane Eleonu Robinson

Walden Dissertations and Doctoral Studies

This Doctor of Nursing Practice project focused on educating providers to fill in knowledge gaps in how to effectively manage chronic pain. The lack of knowledge about the evidence-based recommendations for treating chronic pain was the practice gap. Standardized training protocols to instruct pain management professionals and address disparities in chronic pain management care should be in place to guarantee that all patients in need of chronic pain management have access to culturally appropriate education.

Re-Education On Chlorhexidine (Chg) Bathing Protocol Affects Patient Chg Bathing Compliance And Surgical Site Infection (Ssi) Rates, Mary Samantha Ross

Doctoral Dissertations and Projects

Surgical site infections (SSI) are considered a hospital-acquired infection, leading to increased hospital length of stay (LOS), readmission rates, increased cost, morbidity, mortality rates, and poor postoperative outcomes. The literature review demonstrated the benefits of preoperative Chlorhexidine (CHG) bathing, but called for standardized protocols, improved education, and patient compliance. Research and clinical experience supported the need for improved patient compliance with CHG bathing. Consistent SSI rates even after protocol changes called for re-education of nursing staff in addition to addressing patient compliance issues. Therefore, providing re-education on the updated protocol, which addresses patient compliance issues, can lead to a reduction …

A Phenomenological Hermeneutic Study Of The Lived Experiences Of Pre-Licensure Nursing Students’ First Semester Clinical Rotations Following Simulation Learning, Ogochukwu Vera Nnakwe

Doctoral Dissertations and Projects

This phenomenological hermeneutic study aims to understand the lived experiences of pre-licensure nursing students during their clinical rotation semester following simulation learning at Southeastern University. The guiding theory for this study is Kolb’s experiential learning theory (Kolb, 1984). Simulation learning in nursing education is a teaching approach that lets learners practice practical nursing skills in a safe environment without risking patient safety, thus bridging the gap between theory and practice (Mishra et al., 2023). It offers students opportunities to improve their knowledge of clinical skills and enhance their abilities (Koukourikos et al., 2021). The study involved a sample of 12 …

Barriers And Facilitators To Health Literacy Among Black Americans With Overweight And Obesity In South Carolina: A Mini-Ethnographic Study, Shelly Campbell-Timmons

Doctoral Dissertations and Projects

The purpose of this qualitative mini ethnography adapted from traditional ethnography with limited time and scope, was to explore and understand perceptions of barriers and facilitators to health literacy among Black Americans with overweight and obesity in three South Carolina counties. Population data showed that approximately 40.3% of U.S. adults are obese. Moreover, Non-Hispanic Black communities are disproportionately affected by overweight and obesity despite efforts to combat the weight-related health risk. Still, limited health literacy should be the focus of public health strategies like teach-back and plain language communication, to address overweight and obesity prevalence and disparities. The study was …

Understanding The Lived Experiences Of Individuals With Post-Acute Sequelae Of Sars-Cov-2 Infection (Pasc) In Rwanda: A Phenomenological Qualitative Study, Iliza Grace Ndatinya, Simal Thind, Fernand Rwamwejo

Global Health Articles

OBJECTIVES: To qualitatively explore the lived experiences of individuals with post-acute sequelae of SARS-CoV-2 infection (PASC) in Rwanda, with the aim of informing context-appropriate interventions to improve patients' quality of life.

DESIGN: Qualitative, phenomenological study using in-depth interviews and thematic analysis.

SETTING: All provinces of Rwanda, including the City of Kigali.

PARTICIPANTS: Adults who tested positive for PASC during a nationwide prevalence study were purposively sampled across all study sites. A total of 30 people were interviewed before saturation was reached.

RESULTS: Participants' lived experiences with PASC were characterised by numerous themes. Despite describing significant life changes since their COVID-19 …

Feasibility And Acceptability Of Perioperative Application Of Biofeedback-Based Virtual Reality Vs Control For Pain And Anxiety In Children And Adolescents Undergoing Surgery: Pilot Randomized Controlled Trial, Anna Lin, Brenna Rachwal, Lindsey Asti, Zandantsetseg Orgil, Isabela Santiago, Lili Ding, Susmita Kashikar-Zuck, Christopher King, Sara Williams, William Black, Peter Minneci, Vanessa Olbrecht

Department of Anesthesiology Faculty Papers

BACKGROUND: The impact of biofeedback-based virtual reality (VR-BF) on pain and anxiety in pediatric surgical patients remains unexplored.

OBJECTIVE: The objective of this study was to evaluate the feasibility and acceptability of perioperative VR-BF use in children and adolescents.

METHODS: We performed a single-blind, 2-arm, randomized pilot trial. Children aged 12 to 18 years undergoing surgery with expected moderate-to-severe postoperative pain and more than 1 overnight admission were randomized (1:1) to the intervention or control group. Participants in the intervention group received VR-BF using ForeVR (functional outcome response to engaging virtual reality [VR]), a novel, gamified digital intervention that integrates …

Successful Treatment Of Recurrent Epithelioid Trophoblastic Tumor (Ett) With Pembrolizumab After Pembrolizumab: A Case Report And Review Of Literature In Treatment Of Ett, Sarah Mokma, Sarah Alnaif, Nicholas Cardillo

Abington Jefferson Health Papers

BACKGROUND: Epithelioid Trophoblastic Tumors (ETT) are rare, which makes an optimal treatment regimen difficult to determine. Since PD-L1 is expressed in placental tissue and in gestational trophoblastic neoplasia (GTN), immunotherapies such as pembrolizumab have been proposed as possible treatments.

CASE PRESENTATION: The case presented is a 50-year-old postmenopausal female who presented with postmenopausal bleeding and a large, fungating cervical mass. Cervical biopsies confirmed ETT. The patient underwent primary debulking surgery with radical abdominal hysterectomy, bilateral salpingo-oophorectomy, and sigmoid colon resection. The patient was diagnosed with a FIGO Stage IV ETT due to tumor extension to sigmoid colon with a high-risk …

Caregiver Burden And Health-Related Quality Of Life Among Parents Of Children With Duchenne Muscular Dystrophy, Ahmed K. Bamaga Bamaga

Journal of Medical Rehabilitation Science

Background: Caring for a child with Duchenne muscular dystrophy (DMD) places significant physical and emotional demands on parents and may negatively affect caregiver quality of life (QoL). This study assessed caregiver burden and QoL among parents of children with DMD.

Methods: This study included 77 parents of children with genetically confirmed DMD recruited from two pediatric neurology and pediatric neuromuscular clinics (King Abdulaziz University Hospital and Alsalama Hospital, Jeddah, Saudi Arabia). Caregiver burden was assessed using the 22-item Zarit Burden Interview (ZBI), and caregiver QoL using the Short Form-36 (SF-36) physical and mental component summary scores (PCS, MCS). Group comparisons, …

Operative Vs Non-Operative Management Of Ventral Hernia: A Population Based Study Of Long-Term Benefits And Consequences, Sourav Podder, Julia A. Baran, Scott H. Koeneman, Francesco Palazzo, Nicole L. Dugan, Christopher Keating, Sami Tannouri

Department of Surgery Faculty Papers

Purpose: Ventral hernia (VH) management has progressed beyond simply physical repair of the defect. It now involves a strategy that purposefully restores abdominal core function and prevents future complications. This study investigates the association between ventral hernia repair (VHR) and functional disorders related to the abdominal core in addition to bowel obstruction, opioid misuse, and physical therapy utilization.

Methods: This retrospective cohort study used administrative codes from the TriNetX database. The outcomes of interest were spine and pelvic floor dysfunction, constipation, incontinence, genital prolapse, bowel obstruction, opioid misuse, and physical therapy utilization.

Results: A total of 587 384 patients were …

Neonatal Outcomes In Twin Pregnancies With Birthweight Discordance: A Five-Year Retrospective Cohort Study, Marjan Mahboubi, Shadya Mohammed Salim Al Saeghi, Hansa Dhar, Dina Mohamed Abd El Fatah, Rowaida Elraih Omran Mensour, Qamariya Khalfan Saud Ambu-Saeidi

Sultan Qaboos University Medical Journal

Objectives: This study aimed to evaluate neonatal outcomes associated with birthweight discordance in twin pregnancies managed at a regional tertiary care centre in Oman. Methods: This five-year retrospective cohort study (2020–2024) was conducted at Nizwa Hospital, Nizwa, Oman, and included twin pregnancies of ≥ 24 weeks' gestation. Birthweight discordance was defined as ≥ 20%. Multivariable logistic regression analysis was performed, adjusting for gestational age at delivery, chorionicity, preeclampsia and gestational diabetes mellitus. Results: A total of 226 twin pregnancies were included, of which 45 (19.9%) had birthweight discordance ≥ 20%. Discordant pregnancies were delivered at an earlier gestational age than …

Follistatin Regulates Tooth Root Furcation Morphogenesis, Liu Yang, Ju-Kyung Jeong, Hwajung Choi, Tak-Heun Kim, Hyuk-Jae Edward Kwon, Sung-Won Cho, Martin Matthew Matzuk, Eui-Sic Cho

Faculty, Staff and Students Publications

Follistatin (Fst), an extracellular inhibitor of the TGF-β signaling pathway, plays a critical role in tooth development, particularly in crown morphogenesis and enamel patterning. While molar root number is conserved within species and between upper and lower jaws, the molecular mechanisms governing root patterning remain largely unknown. To investigate the role of Fst in root formation, we analyzed K14-Cre-mediated Fst knockout mice. During embryonic and early postnatal stages, Fst was dynamically expressed in the dental epithelium including the lingual epithelium, and primary and secondary enamel knots, as well as in the dental mesenchyme at the base of the dental papilla. …

Starting To Feel Like A Clinician: Graduate Student Experiences Of Communication Partner Training For People With Aphasia, Katie A. Strong, Esther S. Kim, Aura Kagan, Nina Simmons-Mackie

Teaching and Learning in Communication Sciences & Disorders

Communication partner training (CPT) is among the most evidence-based interventions for supporting people with aphasia, yet many speech-language pathologists report not implementing it in practice, and graduate students frequently report low confidence communicating with people with aphasia prior to targeted training. This qualitative descriptive study examined graduate students' experiences learning CPT through a course-embedded, multi-modal experiential approach with structured reflection. Written reflections from 79 first-year graduate students across two university programs served as the data source. Reflections were analyzed using reflexive thematic analysis. Three themes emerged: Learning by Design, reflecting students' metacognitive awareness of the pedagogical elements most meaningful …

When Students Use Ai Before They Learn To Think Clinically: Cognitive Offloading In Communication Sciences And Disorders Education, Salim Alani

Teaching and Learning in Communication Sciences & Disorders

Generative artificial intelligence is becoming part of how students study, write, summarize, and prepare for coursework in communication sciences and disorders (CSD). Much of the current discussion in higher education has focused on plagiarism, academic integrity, and responsible technology use. Those concerns matter, but they do not fully address what may be a larger educational issue in professional preparation programs. Students can now generate polished explanations, study materials, treatment rationales, and clinical summaries quickly, sometimes before independently developing the reasoning skills those tasks are intended to build. This paper examines cognitive offloading in CSD education, defined here as the shifting …

Integrating Public Health Into Communication Sciences And Disorders Curriculum, Whitney D. Perkins, Yalanda M. Barner, Jennifer Wiles, Brandi Newkirk-Turner

Teaching and Learning in Communication Sciences & Disorders

The field of Communication Sciences and Disorders (CSD) is increasingly integrating public health into its practice and research. This is because less than 10% of speech-language pathology and audiology graduate programs are housed within Colleges or Schools of Public Health (PH), reducing the likelihood that students in CSD have the opportunity for coursework and co-curricular activities that integrate PH and CSD. In this paper, we discuss the holistic approach we used to integrate PH into a CSD program at a Historically Black University. The approach was guided by PH and CSD accreditation standards and involved a didactic course, CSD courses …

Building Interprofessional Competency-Based Education Into Graduate Program Clinical Experiences: A Childhood Apraxia Of Speech And Sensory Processing Disorder Case Study Analysis, Kate Nealon, Zahava L. Friedman

Teaching and Learning in Communication Sciences & Disorders

Abstract

Supporting interprofessional competency-based education requires embedding educational opportunities within coursework and clinical experiences. This education prioritizes student engagement and learning from, with and about other professionals to support collaboration and communication amongst clinicians (CAIE, 2020). While the provision of interprofessional clinical opportunities is recommended, it is challenging to implement effectively in professional and pre-professional settings. Academic settings have the unique ability to provide interprofessional collaborative clinical experiences for students. This pilot study focuses on Speech Language Pathology (SLP) and Occupational Therapy (OT) clinical assessment experiences, specifically in the context of pediatric motor speech and sensory processing disorders. These disorders …

Analysis Of The Influence Of Anthropometric Dimensions Of Postural Ergonomics Using Multiple Linear Regression, Gashbeen Faisal Najmaddin, Edrees Muhammed Tahir Harki

Al-Bahir

Ergonomics is the study of designing and arranging a workspace or product to optimize the “fit” between people and their work, ensuring safety, comfort, and efficiency. The scientific literature indicates that ergonomic perspectives on the workplace are connected to the anthropometrics of societies. This study primarily aims to create a model that integrates multiple predictive variables to estimate the target variable. Multiple linear regression analysis is used to identify how different anthropometric dimensions predict postural ergonomics during prolonged sitting. Based on the regression models’ results, the predicted can be calculated using user anthropometry and existing chair dimensions. Furthermore, the primary …

Evaluating Medical Student Geriatric Competency Using A 5ms-Based Assessment Tool, Lauren R. Hersh Md, Amy Cunningham Phd, Mph, Xiya Wu Md

Cooper Rowan Medical Journal

INTRODUCTION

Driven by an aging Baby Boomer generation, the United States is navigating a demographic transformation with far-reaching implications that include increased demand for chronic disease management and long-term care as well as increased stress on both healthcare costs and infrastructure. Generating a workforce competent in the delivery of care to older patients with complex, multimorbid conditions is fundamental to addressing this shift. Recognizing that the development of primary and specialty care physicians skilled in geriatric care begins in medical school, the American Geriatric Society developed minimum competencies grounded in the Geriatric 5Ms (Mind, Mobility, Medication, Multicomplexity, and …