Digital Commons Network^™

Cytomegalovirus Immune Responses And Cognitive Impairment In People With Human Immunodeficiency Virus, Lakshmi Chauhan, Debashis Ghosh, Beau Ances, Katherine Tassiopoulos, Kunling Wu, Adriana Weinberg, Kristine M Erlandson

2020-Current year OA Pubs

People with human immunodeficiency virus (HIV) have an earlier occurrence of aging complications, including cognitive impairment (CI). Chronic immune activation from cytomegalovirus (CMV) may contribute to increased inflammation and CI. We explored this association using several measures of CMV immune response among people with HIV (PWH). In a case-control design, we compared CMV immunoglobulin G (IgG), enzyme-linked immunospot (ELISpot), and flow cytometry between cases (subsequent CI) and controls (no CI). Baseline CMV IgG, CMV ELISpot, or flow measures were not associated with subsequent CI. This exploratory analysis supports larger studies using more nuanced immunophenotyping to clarify relationship between CMV and …

Using An Automated Evaluation System To Improve Medical Student Evaluation Response Rate And Reduce Administrative Burden, Chaiya Laoteppitaks, Alisha Agarwal, Jason Gonzalez, Nina Mingioni, Xiao C. Zhang

Department of Emergency Medicine Faculty Papers

BACKGROUND: Email reminders facilitate timely task completion but can create substantial administrative burdens for clerkship staff. In our emergency medicine (EM) clerkship, third-year medical students initiate digital evaluation requests after each clinical shift, requiring frequent manual reminders to maintain completion rates. The time-intensive nature of this process highlights the need for a more efficient and scalable approach.

METHODS: This multi-site, pre-post study evaluated clinical performance evaluation completion rates and time to completion during the required EM clerkship over 48 weeks before and after implementation of an automated reminder system in September 2024. The system integrated existing survey functionality with Microsoft …

Relationship Between High-Risk Cytogenetic Abnormalities And Tent5 Mutations And Disease Outcomes Of Multiple Myeloma Patients, Erica Lea Richardson

Walden Dissertations and Doctoral Studies

Multiple myeloma (MM) patients have the lowest 5-year cancer survival rates due, in part, to the time it takes for symptoms to develop and the presence of one to four high-risk cytogenetic abnormalities (HRCA). The Terminal Nucleotidyltransferases 5 (TENT5) subfamily, which regulates myeloma cell migration and tumorigenesis, may also increase the risk for developing MM and impact survival rates. The purpose of this study was to investigate the association between the number of HRCA and TENT5 mutation hits with disease outcomes in MM patients while controlling for the stage of the disease (i.e., I, II, or III) at diagnosis. The …

Prospective Chest Ct Cohort With Opportunistic Multidimensional Phenotype Capture In Routine Care At A Tertiary Hospital In Western China: Protocol, Heng Zhang, Caipan Gong, Chunfeng Xiang, Shucai Wu, Xifeng Liang, Huazhang Song, Yanhan Xiang, Shuang Liang, Xiaoling Peng, Xiaogang Ren, Yang Li, Hongyan Li, Jing Song, Yuanhua Cheng, Yingchun Xiang, Zhiwei Wu, Chungang Zhao

Research outputs 2022 to 2026

Introduction: Routine chest CT contains clinically relevant multidomain information beyond the immediate examination indication, but translation into routine care requires more than identifying individual biomarkers. This protocol describes a prospective observational cohort designed to evaluate whether technical assessability, standardised multidomain research phenotyping, routine radiology reporting and documented care can be linked reproducibly within routine clinical chest CT at a tertiary hospital in western China.

Methods and Analysis: This is a single-centre, prospective, consecutive-enrolment observational imaging cohort embedded in routine outpatient and inpatient chest CT practice rather than a dedicated screening programme. The study is organised around a scan-to-phenotype-to-report-to-care framework while …

Staff Education To Improve Sleep Hygiene Knowledge And Competency Among Nursing Staff On An Inpatient Behavioral Health Unit, Jennings Ubadi Mekoba

Walden Dissertations and Doctoral Studies

This staff education project addressed the gap in standardized knowledge and implementation of evidence-based sleep hygiene interventions among nursing staff on an inpatient behavioral health unit. Sleep disturbances affect 80%–90% of psychiatric patients and directly impact treatment outcomes and recovery. I developed the practice-focused question to consider whether an evidence-based sleep hygiene education program would enhance the awareness, knowledge, and practices of the nursing staff regarding sleep hygiene interventions. A thorough literature review of 23 high-quality sources formed the background for the development of a structured educational intervention that encompassed assessment methodologies, nonpharmacological interventions, environmental interventions, and patient education interventions. …

Comprehensive Evaluation Of At(N) Imaging Biomarkers For Predicting Cognitive Decline, Tom Earnest, Braden Yang, Deydeep Kothapalli, Aristeidis Sotiras, Alzheimer's Disease Neuroimaging Initiative

2020-Current year OA Pubs

INTRODUCTION: Few studies have investigated how different Alzheimer's disease biomarker definitions affect predictions of cognitive decline.

METHODS: We predicted cognitive decline using 42 biomarker definitions spanning amyloid beta, tau, and neurodegeneration in 383 ADNI participants with baseline neuroimaging and longitudinal cognitive assessments. We identified optimal predictors for each pathology and variable type (continuous, binary, non-binary categorical) using nested cross-validation. Models were compared against support vector machines (SVMs) incorporating brain-wide pathology. In a subsample, we compared imaging-based biomarkers with biofluids (cerebrospinal fluid and plasma).

RESULTS: We observed substantial variability in accuracy, even for measures of the same pathology. Tau biomarkers were …

The Impact Of Unilateral Versus Bilateral Ankle Bracing On Kinematics, Kinetics, And Performance In Volleyball Players, Stephen M. Boulanger, Derek M. R. Kivi, Carlos Zerpa, Paolo Sanzo

Topics in Exercise Science and Kinesiology

This study examined the effect of different types of ankle braces (Ankle Stabilizing Orthosis (ASO) vs. T2 Active Ankle(T2)) when worn unilaterally (UNI), bilaterally (BI), and with no brace worn (UB) on lower extremity kinematics and kinetics during a vertical jump and agility test. Twenty-two competitive volleyball players completed both a vertical jump test and agility T-test under five bracing conditions. Vertical jump height (VJH), ankle dorsiflexion (ADF), ankle plantarflexion (APF), knee flexion (KF), hip flexion (HF), vertical ground reaction force (vGRF), and vertical impulse were measured during the vertical jump test, while time to completion was measured for the …

Sociodemographic And Geographic Factors Underlying Breast Cancer Survival Disparities Among Women In The United States, Colletta Brabham-Orr

Walden Dissertations and Doctoral Studies

Breast cancer-specific mortality in the United States remains higher among women in rural and socioeconomically disadvantaged areas, yet few population-based studies have been conducted to jointly scrutinize demographic and structural determinants of this disparity. Informed by the social determinants of health framework, this secondary data analysis, using records from the SEER Research Plus database, examined the association between age at diagnosis, race and ethnicity, rural/urban residence, county-level median household income, and breast cancer-specific mortality among U.S. women aged 18 and older diagnosed with malignant invasive breast cancer between 2010 and 2020 (N = 285,865). Bivariate chi-square tests and binary logistic …

Management Of Non-Survivable Head Trauma: Opportunities For Improvement, Sanjana R. Salwi, Mackenzie D. Castellanos, Therese Murphy, Pious D. Patel, Sonia Ajmera, Alex P. Vaz, Connor A. Wathen, Niels D. Martin, Monisha A. Kumar, James M. Schuster, Dmitriy Petrov

Department of Neurosurgery Faculty Papers

BACKGROUND: Managing patients with non-survivable head trauma who do not meet brain death criteria presents significant ethical and clinical challenges. Decisions frequently fall to surrogates with limited guidance, particularly when organ donation status is unknown. This study assessed physician perspectives on communication, interventions, and institutional factors.

METHODS: We conducted a national survey of academic neurosurgery, trauma surgery, and neurocritical care programs. Items examined communication barriers, interventions by donor status, institutional support, and a dissonance measure for interventions viewed as inappropriate.

RESULTS: A total of 133 physicians responded. Top communication barriers were medical literacy, unclear patient values, and intrafamily conflict. Physicians …

Firearm Safety And Suicide Prevention In Older Adults: A Primary Care Clinical Framework., Rebecca Delp, Erik E. Langenau

PCOM Scholarly Works

Firearm-related injury and suicide represent a critical public health challenge in the United States, with older adults experiencing the highest rates of firearm suicide. Approximately 70 % of suicides among older adults involve a firearm, with white males over age 70 at the highest risk. Despite high household firearm access and unsecured storage, standardized screening and counseling in primary care remain underutilized. Primary care physicians are uniquely positioned to identify clinically vulnerable patients and evaluate lethal means safety through longitudinal relationships during routine encounters. This clinical practice report presents an evidence-based framework for firearm suicide risk assessment, clinical communication, and …

Turkish Translation And Cultural Adaptation Of The Evaluation In Ayres Sensory Integration (Easi), Aymen Balikci, Ayse Firdevs Aracikul Balikci, Isabelle Beaudry-Bellefeuille, Gamze Cagla Sirma, Fatos Kirteke, Zoe Mailloux, L. Diane Parham, Susanne Smith Roley, Roseann C. Schaaf

Department of Occupational Therapy Faculty Papers

INTRODUCTION: Cultural sensitivity and relevance are critical components for best practice in occupational therapy assessment. The Evaluation in Ayres Sensory Integration (EASI) is a performance-based assessment designed to evaluate sensory perception, sensory reactivity, postural control, ocular control, bilateral integration, and praxis abilities in children aged 3-12 years. Before the development of this tool, no standardized performance-based assessment of sensory integration functions had included a normative Turkish sample. The objective of this study was to translate and culturally adapt the EASI for Türkiye.

METHOD: A seven-step process for translation and cross-cultural adaptation, grounded in established methodology, was applied. The steps included …

Journal Ida 2023 102 4

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.

Journal Ida 2023 102 3

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.

Common Symptoms In Homoeopathy. Are They Really Useless? Results From An Empirical Assessment Of Best Cases Data From A Bayesian Perspective: An Observational Study, José Enrique Eizayaga, Lex L. Rutten

Indian Journal of Research in Homoeopathy

Background: In seeking the homoeopathic medicine that best fits their case, homoeopaths traditionally yield greater value to the most peculiar symptoms, while dismissing those they believe to be common, according to the number of medicines found in repertories' rubrics. Objectives: To assess the validity of the following homoeopathic usual practice notions: common symptoms are useless and prescription should rely on peculiar ones. Methods: Empirical data from the Best Chronic Homeopathic Cases (BCHC) and the COVID-19 cases collection databases were analysed by using a Bayesian approach. Symptoms' prevalence and likelihood ratio (LR) were calculated. Results from three very common symptoms in …

Conventional Medicine, Industry, And Homoeopathy: Between Scientific Paradigms, Economic Interests, And Structural Prejudices, Jozelio F. De Carvalho

Indian Journal of Research in Homoeopathy

This article discusses the key epistemological, economic, and structural factors that contribute to the marginalisation of Homoeopathy within contemporary biomedical science. This integrates information from scientific literature, policy discussions, and historical sources addressing evidence hierarchies, trial design, funding patterns, and institutional determinants of scientific legitimacy in medicine. Examples from systematic reviews, randomised controlled trials, pragmatic studies, and N-of-1 research frameworks are considered to contextualise how methodological models may favour or disadvantage specific therapeutic paradigms. Homoeopathy remains a contested field not only due to conflicting results in clinical studies, but also because classical randomised trial designs may fail to adequately capture …

Homoeopathic Management Of Primary Venous Leg Ulcer With Apis Mellifica: A Case Report, Tejashri V. Thakare, Alfisha T. Shaikh

Indian Journal of Research in Homoeopathy

Introduction: Venous leg ulcers are common chronic lower-limb ulcers, primarily resulting from chronic venous insufficiency, venous hypertension, and impaired venous return. They are associated with oedema, pain, skin changes, restricted mobility, delayed healing, and significant morbidity. Despite conventional approaches such as compression therapy, wound dressings, antibiotics, and surgical interventions, healing may be prolonged, and recurrence is common. Case Summary: A 76-year-old male presented with a three-month history of a non-healing ulcer of the left lower limb, accompanied by oedema, pain, swelling, and difficulty in walking. Based on individualisation of symptoms, Apis mellifica 30C was prescribed. Significant symptomatic relief was observed …

Encouraging Innovation Through Intellectual Property Rights In Homoeopathy, Parth Aphale, Shashank Dokania, Himanshu Shekhar

Indian Journal of Research in Homoeopathy

NA

Indian Standard For Safe Handling Of Biotherapeutic Products Used In Homoeopathy: Guidelines, Kumar Vivekanand, Indra Gaurav Saxena, Divya Taneja, Shailendra K. Saxena, Shrishti Dixit, Raj Kumar Manchanda

Indian Journal of Research in Homoeopathy

Biotherapeutic products used in Homoeopathy are derived from biological sources of human, animal, microbial and other origins and include pathological and non-pathological preparations such as nosodes and sarcodes. Owing to the biological nature of these materials, their safe handling, preparation, storage, testing and documentation require systematic controls to protect personnel, the public and the environment. The Indian Standard `IS 19901:2026, Safe Handling of Biotherapeutic Products Used in Homoeopathy — Guidelines', provides a comprehensive framework for risk assessment, biosafety classification, containment, determination of first safe dilution (FSD), safety and efficacy evaluation, quality assurance, formulation, dispensing and documentation. The standard also establishes …

Evidence-Based Interventions For Suicide Prevention, Deepthi Gilla

Indian Journal of Research in Homoeopathy

NA

Prioritising Safe Care For Noncommunicable Diseases: A Call To Action On World Patient Safety Day 2026, Subhash Kaushik

Indian Journal of Research in Homoeopathy

NA

Raman Spectroscopy Characterisation Of 5c Potency Of Homoeopathic Drugs Nux Vomica, Thuja Occidentalis And Nitricum Acidum, Alfonso Tramontana, Giuseppe Acri, Lucia Denaro, Massimo Mattozzi, Maria Antonietta D'Avanzo, Barbara Testagrossa

Indian Journal of Research in Homoeopathy

Background: The physicochemical characterisation of homoeopathic medicines remains a challenge. Raman spectroscopy is a promising tool for identifying structural modifications in the solvent matrix and specific vibrational ``fingerprints'' induced by the potentisation process. Objective: This study aimed to characterise three remedies (Nux vomica, Thuja occidentalis, and Nitricum acidum - 5C potencies) using Raman spectroscopy to identify specific vibrational markers and evaluate the technique's ability to differentiate between different preparations within a complex matrix. Materials and methods: The drugs were analysed as crushed granules (solid state) and after dissolution in betamethasone disodium phosphate (liquid state). Raman spectroscopy was …

Immunomodulatory Activity Of Bryonia Alba 6c And 30c In Sheep Red Blood Cell-Immunised Mice: Insights From Humoral And Delayed-Type Hypersensitivity Responses, Abanti Goswami, Narasimha Kumar Gv, Vara Prasad Saka, Suneel Prajapati, Bibaswan Biswas, Pankaj Gupta

Indian Journal of Research in Homoeopathy

Background: Malnutrition and infectious diseases compromise immune responses, increasing vulnerability to infections. The introduction of plant-derived immunomodulators, such as Bryonia alba (Bry. alba), is attracting attention due to their lower side effects compared with chemical drugs. In Homoeopathy, Bry. alba has long been utilised to treat a wide range of illnesses, including viral infections, and is recognised for its immunomodulatory properties. Objectives: To evaluate the immunomodulatory effects of Bry. alba 6C and 30C potencies on humoral and delayed-type hypersensitivity (DTH) in sheep red blood cell (SRBC)-immunised BALB/c mice. Materials and methods: Fifty BALB/c mice were divided into five …

A Retrospective Descriptive Profile Of Cancer Patients Seeking Homoeopathic Care In A Semi-Rural South African Setting, Radmila Razlog

Indian Journal of Research in Homoeopathy

Background: Patient profiling renders valuable information about the population's healthcare-seeking behaviours, critical for effective patient management. Khula Natural Health Centre (KNHC) in South Africa provides healthcare to rural communities, within the scope of Homoeopathy. Objective: The study aimed to create a preliminary cancer patient profile of KNHC from April 2017 to August 2024. Method: This retrospective study adopted a descriptive, exploratory design. Anonymised patient data was extracted from the KNHC database. Data that met the inclusion criteria were descriptively analysed to summarise and describe the dataset. Results: Forty-six participants' data, presenting a range of cancers, consulted at KNHC for homoeopathic …

Actinic Lichen Planus Treated With An Individualised Homoeopathic Approach: A Case Report, Aloke Kumar Ghosh, Shilpa Mandal, Ritika Bose, Sumanta Kamila

Indian Journal of Research in Homoeopathy

Introduction: Lichen planus (LP) is an idiopathic chronic inflammatory disorder of the skin and mucous membranes. Actinic lichen planus is a rare photosensitive variant that affects sun-exposed areas and may significantly impair quality of life due to its disfiguring nature. Conventional management primarily involves topical or systemic corticosteroids, which are associated with adverse effects and frequent relapses. Scientific literature on homoeopathic management of actinic LP remains limited. Case summary: A 61-year-old woman presented with pruritic, purple-black plaques over the forehead and was clinically diagnosed with actinic LP persisting for the last five months. Causticum in LM potency was prescribed after …

Treatment Of Exfoliative Dermatitis Using Homoeopathic Dilution Graphites In Lm Potency: A Case Report, K. C. Muraleedharan, Kanishka Gandhi

Indian Journal of Research in Homoeopathy

Introduction: Exfoliative dermatitis is a severe form of skin irritability that causes significant erythema and/or scaling. Most of the time, it is a secondary process, and numerous factors could contribute to the development of this widespread skin condition. Psoriasis is the most prevalent reason for exfoliative dermatitis among all dermatologic disorders. Case Summary: A 49-year-old male presented with skin exfoliation with itching, burning and pain on the whole body for 2 weeks associated with serous discharge from lesions at the back and axillae secondary to psoriasis. A single homoeopathic medication Graphites in LM potencies over two months was prescribed that …

Research Highlights, Gandham Kumuda, Monika Chandyoke

Indian Journal of Research in Homoeopathy

NA

World Homoeopathy Day 2026: Homoeopathy For Sustainable Health, Candy Benny, Sonu Kumar, Divya Taneja, Pankhuri Misra, Renu Mittal, Subhash Kaushik

Indian Journal of Research in Homoeopathy

The World Homoeopathy Day (WHD) 2026 – a two-day interactive forum to commemorate the 271^st birth anniversary of Dr. Samuel Hahnemann, founder of Homoeopathy, was held on 10^th – 11^th April 2026 at Vigyan Bhawan, New Delhi, India. The event was organised by CCRH, NCH, and NIH under the aegis of the Ministry of Ayush. Centered on the theme of ``Homoeopathy for Sustainable Health'', the event emphasised the role of Homoeopathy in promoting and ensuring sustainable health. The event witnessed participation from approximately 1,800 delegates comprising policy makers, practitioners, researchers, academicians, and students. There were a …

Vaccinosis And Its Cure By Thuja With Remarks On Homoeoprophylaxis By Dr J. Compton Burnett, Rahul Yadav, J. P. Tripathi

Indian Journal of Research in Homoeopathy

NA

Integrating Interprofessional Education To Strengthen Team-Based Mental Health Care, Adebisi Tijani

Doctor of Nursing Practice Projects

Fragmented interprofessional collaboration in outpatient mental health settings compromises care coordination and patient engagement. This quality improvement (QI) project implemented a structured interprofessional education (IPE) workshop series to improve team collaboration and reduce patient no-show rates in an outpatient mental health clinic. Guided by Bandura's Social Cognitive Theory and Lewin's Change Management Model, the project used a pre-post, single-group design with 12 licensed mental health professionals. The team measured collaboration with the Assessment of Interprofessional Team Collaboration Scale-II (AITCS-II) and collected aggregate patient no-show rates from the electronic health record. The intervention consisted of four monthly, one-hour workshops covering role …

Intouch Week Of September 21, 2026, New York Medical College

InTouch

• NYMC Celebrates Opening of Newly Renovated Clinical Skills and Simulation Center
• MFCH Named in Top 50 Best Children's Hospitals for Cancer
• Students Gain Early Research Experience in the Quest to Combat Obesity and Cardiometabolic Disease
• Aubrey Sperling Johnson Awarded Prestigious AOA Research Fellowship
• 60 Seconds of Science with Vishnu Chaturvedi, Ph.D.
• NYMC and TU Hosts Ninety Minutes: The Medical Magazine of the Web
• TCDM Reaches Out in New Mexico
• Faculty Spotlight: Hojoong Kwak, M.D., Ph.D., M.S., Bridging Medicine and Molecular Science
• Student Spotlight: SLP Student Selected for ASHA Student Leadership Program