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Alpha-Synuclein Phosphomimetic Y39e And S129d Knock-In Mice Show Cytosolic Alpha-Synuclein Localization Without Developing Neurodegeneration Or Motor Deficits, Youngdoo Kim, Bhupesh Vaidya, Joseph Mcinnes, Huda Y Zoghbi

Duncan NRI Faculty and Staff Publications

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by motor and nonmotor symptoms. Its pathological hallmarks include the accumulation of misfolded alpha-synuclein (α-Syn) in Lewy bodies and Lewy neurites. Phosphorylation of α-Syn is a prominent feature of these inclusions, but its role in disease pathogenesis remains unclear. To identify the role of α-Syn phosphorylation in synucleinopathy, we generated two Snca knock-in (KI) mouse models carrying phosphomimetic mutations at SncaY39 or SncaS129 (Snca^Y39E or Snca^S129D) which manipulated epitopes phosphorylated in the PD brain. Both Snca^Y39E and Snca^S129D KI mice displayed increased α-Syn phosphorylation, enhanced …

The Relationship Between Visceral Fat Accumulation And Risk Of Cardiometabolic Multimorbidity: The Roles Of Accelerated Biological Aging, Tianyu Zhu, Yixing Tian, Jinqi Wang, Zhiyuan Wu, Wenhan Xie, Haotian Liu, Xia Li, Lixin Tao, Xiuhua Guo

Research outputs 2022 to 2026

Objectives: To investigate the association between visceral fat accumulation and the risk of cardiometabolic multimorbidity (CMM) and the potential roles of accelerated biological aging in this relationship. Methods: Using data from the UK Biobank, a nationwide cohort study was conducted using the available baseline body roundness index (BRI) measurement. Biological aging was assessed using the Klemera–Doubal method for biological age and the phenotypic age algorithms. The association between the BRI and CMM was estimated using the Cox proportional hazards regression model, while the roles of biological aging were examined through interaction and mediation analyses. Results: During a median follow-up of …

Demographic Variations In Long Qt Syndrome: Analyzing The Impact Of Gender, Ethnicity, And Environmental Factors On Prevalence And Risk, Heidi Bosch

Senior Honors Theses

Long QT syndrome (LQTS) is an arrhythmic condition characterized by delayed repolarization of cardiomyocytes, identified by prolonged QT interval on an electrocardiogram (ECG). LQTS can be caused by congenital mutations of ion channels or acquired through conditions, medications, and environmental factors. Prolongation of the QT interval can trigger deadly arrhythmia including torsade de pointes (TdP). LQTS has been named the top cause of sudden cardiac death (SCD) for young individuals with anatomically normal hearts. The incidence of LQTS has been reported to be between 1:2000 and 1:2500. The demographic differences in LQTS prevalence have not been thoroughly researched. The incidence …

Rural Access To Multidisciplinary Cancer Care Center For Patients With Pancreatic Ductal Adenocarcinoma, Irene Gielen

Doctor of Nursing Practice

Background
Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer and among the most aggressive malignancies. It is projected to be the second leading cause of cancer related mortality in the United States by 2030. Due to its nonspecific early symptoms, PDAC often remains undetected until advanced stages, limiting treatment options and reducing survival rates.

Purpose
This project evaluated the impact of geographic distance on diagnostic staging and treatment initiation for patients with PDAC referred to the Providence Cancer Institute of Oregon (PCIO) from 2018-2023.

Methods
A retrospective chart review assessed the relationship between geographic distance, demographics, …

Developing A Pandemic-Related Mental Health Micro-Collection For An Academic Library, Dee Anna Phares

Faculty Articles, Papers, and Other Scholarship

Academic library patrons dealing with the impact of trauma, depression, anxiety, or addiction spawned or exacerbated by the COVID-19 pandemic require materials that address the unique conditions that have shaped mental health since late 2019. This paper demonstrates how one academic library endeavored to address patrons’ needs for mental health resources by developing a “Coping and COVID-19” micro-collection.

Improving The Experience Of Self-Injection In Medical Weight Loss Patients Prescribed Glp-1 Agonists: A Quality Improvement Project, Maegan Wing

DNP Projects

Background/Introduction: Obesity is a chronic disease linked to numerous health complications. Glucagon-like peptide-1 (GLP-1) agonists, including Semaglutide, Liraglutide, Dulaglutide, and Tirzepatide, are effective in weight management but require self-injection. Many patients experience barriers such as needle fear, technique difficulties, and anxiety, leading to early medication discontinuation. Data indicates that only 46.3% of patients continue GLP-1 therapy after 180 days, with adherence rates as low as 27.2% (Gleason et al., 2024). Addressing these barriers through structured provider-led self-injection training is essential to improve adherence, enhance patient outcomes, and reduce healthcare costs. Currently, at this DNP project site, there is a …

Training The Brain For Better Aging, Abby Martin

Honors Projects

Aging is associated with natural changes in brain function, but certain interventions can help sustain cognitive health and mitigate risks of neurodegenerative diseases such as Alzheimer’s. This presentation explores the significance of brain fitness as a non-pharmacological approach to enhancing cognitive function. It covers the normal aging process of the brain, key indicators of abnormal aging, and the impact of Alzheimer’s disease, including genetic predispositions and current treatment limitations. Emphasis is placed on brain training exercises, such as puzzles, board games, video games, and nostalgia-based activities, which have been shown to improve memory, attention, and problem-solving skills. Additionally, the role …

Analysis Of Mycoplasma Pneumoniae Cards Toxin In The Air-Liquid Interface Bronchial Culture Model, Alexandria Hernandez

Posters - 2025

Mycoplasma pneumoniae is a pathogen that can cause severe respiratory infection that can rarely be life threating. There are currently no vaccines against M. pneumoniae, and the prevalence of antibiotic-resistant strains of M. pneumoniae is on the rise.1 During infection, M. pneumoniae produces a toxin called Community Acquired Respiratory Distress Syndrome (CARDS) toxin, which plays a role in establishing infection. Analysis of the crystal structure of CARDS toxin protein reveals three protein domains: D1, D2,and D3.

After entering a cell, CARDS toxin traffics by a retrograde process to the ER of the cell, where it undergoes processing.4 Our current studies …

Standardizing Heart Failure Discharges: Reducing 30-Day Readmission Rates, Angela Keziah

Doctor of Nursing Practice Scholarly Projects

Problem Statement: Patients readmitted with heart failure (HF) suffer increased mortality, reduced quality of life, and heightened medical expenses, though most readmissions are preventable with a consistent HF discharge regimen.

Purpose: To determine if a consistent HF discharge regimen using an evidence-based HF discharge checklist tool, including standardized HF education and a scheduled follow-up appointment with their cardiologist within 7-10 days post-discharge, impacted HF 30-day readmission rates.

Methods: An evidence-based HF discharge checklist tool was placed on participants’ charts on the Progressive Care Unit (PCU) and utilized by the PCU nurses to standardize HF discharges.

Inclusion Criteria: The study included …

Soluble Cd13 Is A Potential Mediator Of Neutrophil-Induced Thrombogenic Inflammation In Sars-Cov-2 Infection, Pei-Suen Tsou, Ramadan A. Ali, Chenyang Lu, Gautam Sule, Carmelo Carmona-Rivera, Serena Lucotti, Yuzo Ikari, Qi Wu, Phillip L. Campbell, Mikel Gurrea-Rubio, Kohei Maeda, Sharon E. Fox, William D. Brodie, Megan N. Mattichak, Caroline Foster, Ajay Tambralli, Srilakshmi Yalavarthi, M Asif Amin, Katarina Kmetova, Bruna Mazetto Fonseca, Emily Chong, Yu Zuo, Michael D. Maile, Luisa Imberti, Arnaldo Caruso, Francesca Caccuri, Virginia Quaresima, Alessandra Sottini, Douglas B. Kuhns, Et Al

School of Medicine Faculty Publications

The soluble variant of the ectopeptidase CD13 (sCD13), released from the cell surface by matrix metalloproteinase 14 (MMP14), is a potent pro-inflammatory mediator, displaying chemotactic, angiogenic, and arthritogenic properties through bradykinin receptor B1 (B1R). We revealed a link between sCD13 and amplified neutrophil-mediated inflammatory responses in SARS-CoV-2 infection. sCD13 was markedly elevated in patients with COVID-19 and correlated with disease severity and variants, ethnicity, inflammation markers, and neutrophil extracellular trap formation (NETosis). Neutrophils treated with sCD13 showed heightened NETosis and chemotaxis, which were inhibited by sCD13 receptor blockade. Meanwhile sCD13 did not induce platelet aggregation. Single-cell analysis of COVID-19 lungs …

How Does Racial Bias Impact The Perceptions Of Black Women Regarding Maternal Care?, Tanner K. Braddy

Honors College Theses

Between 1999–2002 and 2018–2021, the maternal mortality rate in the United States increased by 144% from 9.65 to 23.6 deaths per 100,000 live births. Although women of all races are affected by maternal mortality yearly, it is especially prevalent in black women. In the United States, black women are three times more likely to die from pregnancy-related causes than non-black women. Despite advanced medical technology and ongoing research, black women are continuing to die because of pregnancy at an alarming rate. Many studies suggest that discrimination and implicit bias - defined as subconscious feelings, attitudes, prejudices, and stereotypes an individual …

Food For Thought: The Impact Of The Gut-Brain Axis On Mental Health, Emily S. Miiller

Honors Thesis

Research regarding the role of the human microbiome has grown over the years as professionals develop a better understanding of the gut-brain axis. New studies and expanding knowledge on the relationship between the nervous system and gut microbiome promote a deeper understanding of the impact of diet on mental health. Diet plays a crucial role in maintaining a healthy balance between the gut and the brain. Incorporating nutritional modulators, such as probiotics, prebiotics, and vitamins, is crucial for supporting the gut-brain axis by influencing neurotransmitter production, managing inflammation, and promoting the growth of beneficial gut bacteria. On the other hand, …

Let's Grow: Investigating The Relationship Between Houseplants And Mental Health In College Students, Makia G. Adler

Honors Thesis

This literature review explores the potential mental health benefits of houseplants for college students, a population increasingly affected by anxiety and depression. With traditional mental health services strained and often inaccessible, simple and low-cost alternatives are urgently needed. This review examines whether the presence and interaction with houseplants can improve psychological well-being, specifically symptoms of anxiety and depression. Drawing from ten peer-reviewed studies, this review finds a generally positive association between houseplants and mental health, though results vary. Notably, the duration of exposure appears to have little effect, while setting and autonomy in plant interaction are more influential. Interactions in …

Self-Rated Pain And Observed Pain Behavior In Black And White Americans With Chronic Low Back Pain, Matthew B. Jennings, John W. Burns, Benita Jackson, Kristine M. Molina, Mark A. Lumley

Psychology: Faculty Publications

Black Americans report more intense and disabling pain than White Americans, but differences in pain behavior have rarely been studied. The Structured Pain Behavior Test (SPBT), a standardized, video-recorded series of pain-inducing movements, assesses the behavioral expression of pain. We conducted the first test of whether Black Americans with chronic low back pain (CLBP) have greater pain behavior and increased self-reported pain intensity during the SPBT, compared to White Americans. Adults (N = 267) with CLBP (174 Black, 93 White; 57% female) rated their clinical pain severity and interference (Multidimensional Pain Inventory; MPI) and their current pain intensity (Numerical Rating …

Inactivation Of E. Faecium Nrrl B-2354 In Whole Black Pepper By Fluidization With Hydrogen Peroxide Vapor, Daniela Segura

Department of Food Science and Technology: Master of Science with Project Option

This study evaluated Enterococcus faecium NRRL B-2354 as a surrogate for Salmonella inactivation in black peppercorns treated with hydrogen peroxide (HP) vapor via fluidization. The selected parameter for dwell temperature was 60ºC for 60 minutes. The reduction of both Salmonella and E. faecium, along with changes in water activity, color, and residual hydrogen peroxide, were measured before, immediately after treatment and at 24 and 48 hours post-treatment. Results showed that E. faecium exhibited a significantly greater reduction (4.63 ± 0.55 log CFU/g) compared to Salmonella (2.94 ± 0.16 log CFU/g) (p < 0.05), making E. faecium unsuitable as …

Ibuprofen, Flurbiprofen Or Naproxen Sodium Minimally Influences Musculoskeletal Adaptations To Treadmill Exercise In Rats, Brandon Roberts, Alyssa Geddis, Alexandra Ciuciu, Marinaliz Reynoso, Nikhil Mehta, Alyssa Varanoske, Alyssa Kelley, Maximus Leiss, Alexander Kolb, Julie Hughes, Marshall Naimo, Ryan Tomlinson, Jeffery Staab

Department of Orthopaedic Surgery Faculty Papers

BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) may influence musculoskeletal health. The purpose of this study was to compare the effects of three different NSAIDS: naproxen sodium, ibuprofen, flurbiprofen or a placebo on musculoskeletal adaptations in rodents with or without 6 weeks of aerobic exercise.

METHODS: Nine-week-old male Wistar rats (n = 80) were randomized to either exercise (EX) or no-exercise control (CON) conditions and treated with naproxen, ibuprofen (IBU), flurbiprofen (FLU) or placebo (PLA). For exercise, rats ran 5 days per week for 6 weeks at a 5% incline on a motorized treadmill for 30 min. Three-point bending (3 PB) and …

Classic Philosophers On Modern Issues: The Ethics Of Germline Editing, Grace O. Decostanza

Richard T. Schellhase Essay Prize in Ethics

The prospect of using CRISPR-Cas-9 technology to edit human embryos in a process called germline editing has the potential to irreparably change the world as we know it. Many pose the question: if you could save your child from having a disease, would you? But I argue that is not the only—or even, real—question we should be asking. Instead, I ask you, should we be changing humanity as we know it in ways that elude even our foremost scientists? Should we decide what disabilities make people not worth being people? Should we introduce a technology knowing full well that it …

Investigating Mercury Contamination In Urban Fish: Atomic Absorption Spectroscopy And Histological Analysis For Environmental And Human Health, Indy L. Cockrill, Ross Andrew

SPARK Symposium Presentations

Mercury contamination in aquatic ecosystems is a pressing environmental and public health concern, particularly in urban areas where industrial runoff and wastewater contribute to heavy metal accumulation. This study investigates mercury presence in fish from Richland Creek in Nashville, TN, by analyzing histological changes in liver and muscle tissues. Mercury bioaccumulates in aquatic food chains, potentially leading to physiological damage in fish and posing health risks to humans who consume contaminated seafood. While prior research has established mercury’s toxic effects, there is a need for localized studies assessing its presence in urban waterways. The hope is to find histological abnormalities …

Physiotherapy In Community-Based Rehabilitation In Middle And Low-Income Countries: A Scoping Review, Er D. Petil Jr., Napoleon R. Caballero

Philippine Journal of Physical Therapy

Introduction: Community-based rehabilitation (CBR) is a widely recognized approach to address the rehabilitation needs of individuals with disabilities in low- and middle-income countries (LMICs). Physical therapy (PT) plays a crucial role within CBR programs. This study aimed to synthesize the current state of literature regarding the integration of PT in CBR programs in LMICs across Asia, Africa, and Latin America, examining key characteristics, reported outcomes, and challenges to implementation.

Methods: A comprehensive review of literature was conducted, focusing on studies published in the past decade. Data were extracted and synthesized in matrix format to compare and contrast findings across the …

Clinical, Radiological Characteristics And Outcomes Of Primary Headache In Children At A Tertiary Hospital In Kenya: A Retrospective Observational Study, Dorcas Tunje, Katherine Oyieke, Pauline Samia

Paediatrics and Child Health, East Africa

We sought to describe the clinical, radiological characteristics and determine the outcomes of children with primary headache. A retrospective observational study was conducted. Children with primary headache were recruited. Demographic, clinical and radiological data were compiled. Visual Analog Scale was used to determine pain severity. Seventy-three patients were included in the study. Their median age was 10.0 (IQR: 8.0-12.0) years, and 38 (52.1%) were female. Fiftyfour (74.0%) had migraine headache. Majority, 50 (68.5%) reported severe headaches at presentation. Three (4.1%) patients had abnormal findings on MRI while 5 (6.8%) patients had abnormal findings on EEG. Most participants were pain free …

Racial Disparities In Utilization Of Medications And Disease Outcomes In Inflammatory Bowel Disease Patients, Khaled Alsabbagh Alchirazi, Osama Hamid, Thabet Qapaja, Mohammad Aldiabat, Nour Azzouz, Motasem Alkhayyat, Miguel Regueiro

2020-Current year OA Pubs

BACKGROUND: Although traditionally associated with White European ancestry, inflammatory bowel disease (IBD) has increased among different races and ethnicities. Large studies conducted in the United States and Canada have identified more complex disease phenotypes among Black patients. Our study aimed to investigate disparities in IBD treatments and outcomes between Black and White patients in the United States.

METHODS: Using the TriNetX database, adult IBD patients were divided into 2 groups based on race: Black and White patients with IBD, Crohn's disease (CD), or ulcerative colitis (UC). Medical therapy and disease outcomes were evaluated in both groups with 1:1 propensity-score matching. …

Linear Growth During Treatment With A Simplified, Combined Protocol: Secondary Analyses Of Severely Wasted Children 6-59 Months In The Compas Cluster Randomized Controlled Trial, Grace Heymsfield, Kevin Stephenson, Zachary Tausanovitch, André Briend, Marko Kerac, Heather Stobaugh, Jeanette Bailey, Suvi T Kangas

2020-Current year OA Pubs

A simplified, combined protocol treats children with moderate acute malnutrition (MAM), defined by mid-upper arm circumference (MUAC) of <  125 and ≥ 115 mm and no oedema, with 1 daily sachet of ready-to-use therapeutic food (RUTF) and those with severe acute malnutrition (SAM), defined by MUAC <  115 mm and/or oedema, with two daily sachets of RUTF. This protocol was previously shown to result in non-inferior recovery compared to standard treatment that used higher, weight-based RUTF dosing among children with SAM and ready-to-use supplementary food (RUSF) for MAM in a cluster-based randomised controlled trial in Kenya and South Sudan. We conducted a secondary analysis of this trial to compare linear growth among children admitted with MUAC <  115 mm. Linear and ponderal growth were calculated from admission to discharge and visualised using aggregate growth curves. HAZ change adjusted for admission characteristics was negative across the course of treatment but similar across arms [-0.21 ± 0.18 SE in the standard arm, -0.24 ± 0.18 SE in simplified; difference (95% confidence interval) 0.03 (-0.12, 0.18)]. The unadjusted mean ± SE linear growth velocity from admission to discharge was 1.8 ± 0.7 mm/week in the standard arm compared to 1.7 ± 0.7 mm/week in the simplified arm [difference = 0.09 (-0.36, 0.53)] and similar in adjusted analysis. MUAC and weight gain velocities were not significantly different by treatment arm. Reducing the RUTF dose prescribed to children during SAM treatment does not appear to affect linear growth or other growth velocities during treatment.

Aging-Related Hearing Decline And Resting State Networks, Cassidy S. T. Ellsworth

College of Education and Human Sciences: Dissertations, Theses, and Student Research

This study investigated the effects of age-related hearing decline on functional networks using resting-state functional magnetic resonance imaging (rs-fMRI). The main objective of the present study was to examine resting-state functional connectivity (rsFC) and graph theory-based network efficiency metrics in forty-nine adults categorized by age and hearing thresholds to identify the neural mechanisms of age-related hearing decline. RsFC within key brain networks and auditory-related brain regions, including the default mode network, salience network, dorsal attention network, and primary auditory cortices, was assessed using region-of-interest (ROI)-based and graph theory approaches. Functional metrics, such as rsFC strength and global and local efficiency, …

Clinical Case Study: The Effects Of Saltatory Pneumotactile Stimulation Of Glabrous Hand And Perioral Face On Cerebral Oxygenation, Cognitive Performance, And Sensorimotor Function In An Adult Following Left Hemorrhagic Stroke, Tara L. Hull

College of Education and Human Sciences: Dissertations, Theses, and Student Research

Stroke remains a leading cause of adult disability and a significant global health concern. Effective rehabilitation strategies for cognitive and communicative impairments following stroke are limited (Kuhn & Sharman, 2023). One emerging approach involves repetitive somatosensory stimulation to drive cerebral hemodynamic changes, potentially offering a novel rehabilitative method. Functional Near-Infrared Spectroscopy (fNIRS) is a non-invasive, accessible tool for monitoring these changes during stroke recovery. Prior studies suggest tactile stimulation rapidly affects brain hemodynamics (Custead et al., 2015; Oh et al., 2017). This clinical single-case study explored the use of GALILEO saltatory pneumotactile stimulation applied to the face and hand in …

Music And Word Learning In Children Diagnosed With Developmental Language Disorder, Rebekah G. Sweeney

College of Education and Human Sciences: Dissertations, Theses, and Student Research

Purpose: This study investigates whether incorporating music into vocabulary interventions improves rate of learning and retention of words in children with developmental language disorder (DLD). Emerging literature continues to show the plentiful benefits of music as a tool for intervention in many settings, including the world of speech pathology (Levitin, 2024). However, it is also evident that there is a connection between struggling with language, and struggling with musical elements, such as rhythm and pitch perception, particularly in children with DLD (Boorom et al., 2022; Kreidler et al., 2023). This study seeks to tease out if music is an effective …

The Impact Of Provider Communication On Treatment Adherence In Patients With Hypertension And Diabetes, Trey Carlson

Honors Program: Senior Projects (Public)

Current research cites effective provider communication as an important factor in improving treatment adherence and the health outcomes of patients. This study examines the effect of provider communication on treatment adherence in patients with chronic illnesses with a specific focus on hypertension and diabetes. Provider communication was measured using patient satisfaction surveys and treatment compliance was measured as the percentage of hypertensive and diabetic patients with a blood pressure below 140/90 mmHg and hemoglobin A1C levels below 9%. A one-way MANOVA revealed that provider communication had no significant impact on the combined treatment compliance variables for hypertension and diabetes (Wilk’s …

Dental Disparities: An Analysis Of Dental Caries Risk Factors Promoting Disparities Between Rural And Urban Communities In Nebraska, Nick Lounsbery

Honors Program: Senior Projects (Public)

The prevalence of dental caries in the United States remains a public health concern, as it is one of the most common chronic conditions across people of all ages. Research shows that preventative measures including brushing, fluoridated water, and regular checkups are effective strategies to mitigate tooth decay. However, there appears to be a divide between rural and urban populations, as the presence of dental cavities is significantly greater in remote areas in the State of Nebraska. Research methods used in this analysis included analyzing accredited academic literature to illustrate how cavities form from a biochemical perspective. Research methods also …

Making The Invisible Visible: Intersectional Perspectives Of Artist Identity And Multiple Sclerosis In The Us Healthcare System, Anna Liza De Leon Evangelista, Chloé Welmond, Emily Rose, Jennifer Gutierrez, Kelly Sheridan, Madeleine Brown, Marissa Barajas, Rowena Luminarias, Nancy Choe

LMU Theses and Dissertations

The intersection of Multiple Sclerosis (MS), systemic healthcare disparities, and art-making remains underexplored within the arts and health literature. While research often highlights the therapeutic benefits of creative expression, it rarely examines how art-making empowers individuals with MS. This study addresses this gap by exploring: (1) how MS influences participants’ art practice, (2) how art impacts the participants’ experiences of MS, and (3) how individuals navigate the United States healthcare system. The research centers on women and gender expansive individuals and takes an intersectional lens to better understand marginalized experiences of those living with MS. These underrepresented groups frequently encounter …

Advanced Screening For Intimate Partner Violence To Prevent Adverse Pregnancy And Maternal Outcomes, Emilia R. Valdez

Nursing | Student Research Posters

Background: Intimate Partner Violence experienced by pregnant individuals contributes to adverse pregnancy outcomes and maternal health. A mother’s exposure to Intimate Partner Violence (IPV) can affect their ability to carry a healthy pregnancy to term (38 – 40 weeks gestational age) and places them at risk for comorbidities including; Preterm birth, Intrauterine Growth Restriction, Low Birth Weight/ Small for Gestational Age, Premature Rupture of Membranes and Miscarriage. The incidence of IPV screening is not accessible to all pregnant individuals due to healthcare providers lack of education, time constraints in the workplace, bias and discomfort towards IPV. The implementation of …

Comparative Analyses Of Neurorehabilitation Regulations And Health Equity In The U.S., Switzerland, And China: Implications For Universal Health Coverage, Linyue Lu

Switzerland: Global Health and Development Policy

Introduction: As populations age and the burden of neurological conditions rises, equitable access to neurorehabilitation has emerged as a critical yet under-addressed component of Universal Health Coverage (UHC). This comparative study examines how healthcare structures in the United States, Switzerland, and China shape neurorehabilitation equity. Methods: This analysis combines semi-structured interviews with seven healthcare experts (neurorehabilitation clinicians, health economists, and scholars) and a systematic review of peer-reviewed literature, policy documents, and demographic data. Results: In the U.S., fragmented insurance models and high out-of-pocket costs disproportionately limit access for low-income and rural populations. Switzerland’s universal coverage masks the inequities driven by …