Digital Commons Network^™

Assessment Of Cognitive Domains In Major Depressive Disorders Using The Cambridge Neuropsychological Test Automated Battery (Cantab): Systematic Review And Meta-Analysis Of Cross-Sectional And Longitudinal Studies, Danilo Arnone, Reshma Ramaraj, Linda Östlundh, Teresa Arora, Syed Javaid, Romona Devi Govender, Emmanuel Stip, Allan H. Young

All Works

Cognitive difficulties are known to persist after remission of symptoms and to affect psychosocial functioning and quality of life. Cognitive function, measured with the Cambridge Neuro-psychological Test Automated Battery (CANTAB), is a reliable approach to measure cognitive function in major depression. This systematic review and meta-analysis appraise cross-sectional and longitudinal studies that used specific CANTAB tests to measure cognitive function in major depression and the effect of treatment (PROSPERO ID: CRD42022355903). 1212 studies were identified and 41 were included, 1793 patients and 1445 healthy controls. Deficits in executive functions were detected with the Stocking Of Cambridge (SOC) ‘number of problems …

Unraveling The Complexities Of Myeloid-Derived Suppressor Cells In Inflammatory Bowel Disease, Yangzhuangzhuang Zhu, Siyan Cao

2020-Current year OA Pubs

Myeloid-derived suppressor cells (MDSCs) regulate immune responses in many pathological conditions, one of which is inflammatory bowel disease (IBD), an incurable chronic disorder of the digestive tract and beyond. The pathophysiology of IBD remains unclear, likely involving aberrant innate and adaptive immunity. Studies have reported altered population of MDSCs in patients with IBD. However, their distribution varies among patients and different preclinical models of IBD. The expansion and activation of MDSCs are likely driven by various stimuli during intestinal inflammation, but the in-depth mechanisms remain poorly understood. The role of MDSCs in the pathogenesis of IBD appears to be paradoxical. …

Methylome-Wide Association Analyses Of Lipids And Modifying Effects Of Behavioral Factors In Diverse Race And Ethnicity Participants, Eric A Whitsel, Mindy Szeto, Laura M Raffield, Scott Ratliff, Yuxuan Wang, Xuzhi Wang, Alison E Fohner, Megan T Lynch, Yesha M Patel, S Lani Park, Huichun Xu, Braxton D Mitchell, Joshua C Bis, Nona Sotoodehnia, Jennifer A Brody, Bruce M Psaty, Gina M Peloso, Michael Y Tsai, Stephen S Rich, Jerome I Rotter, Jennifer A Smith, Sharon L R Kardia, Alex P Reiner, Leslie Lange, Myriam Fornage, James S Pankow, Mariaelisa Graff, Kari E North, Charles Kooperberg, Ulrike Peters

Faculty, Staff and Student Publications

Circulating lipid concentrations are clinically associated with cardiometabolic diseases. The phenotypic variance explained by identified genetic variants remains limited, highlighting the importance of searching for additional factors beyond genetic sequence variants. DNA methylation has been linked to lipid concentrations in previous studies, although most of the studies harbored moderate sample sizes and exhibited underrepresentation of non-European ancestry populations. In addition, knowledge of nongenetic factors on lipid profiles is extremely limited. In the Population Architecture Using Genomics and Epidemiology (PAGE) Study, we performed methylome-wide association analysis on 9,561 participants from diverse race and ethnicity backgrounds for HDL-c, LDL-c, TC, and TG …

Chronic Viral Mimicry Induction Following P53 Loss Promotes Immune Evasion, Charles A Ishak, Sajid A Marhon, Naïri Tchrakian, Anjelica Hodgson, Helen Loo Yau, Melanie Peralta, Stephanie Gomez, Sheng-Ben Liang, Shu Yi Shen, Raymond Chen, Jocelyn Chen, Biji Chatterjee, Kevin N Wanniarachchi, Junwoo Lee, Nicholas Zehrbach, Amir Hosseini, Parinaz Mehdipour, Siyu Sun, Alexander Solovyov, Ilias Ettayebi, Kyle E Francis, Aobo He, Taiyi Wu, Shengrui Feng, Tiago Da Silva Medina, Felipe Campos De Almeida, Jane Bayani, Jason Li, Spencer Macdonald, Yadong Wang, Sarah S Garcia, Elisa Arthofer, Noor Diab, Aneil Srivastava, Paul Tran Austin, Peter J B Sabatini, Benjamin D Greenbaum, Catherine A O'Brien, Trevor G Shepherd, Ming Sound Tsao, Katherine B Chiappinelli, Amit M Oza, Blaise A Clarke, Robert Rottapel, Stephanie Lheureux, Daniel D De Carvalho

Faculty, Staff and Student Publications

Epigenetic therapies facilitate transcription of immunogenic repetitive elements that cull cancer cells through ‘viral mimicry’ responses. Paradoxically, cancer-initiating events also facilitate transcription of repetitive elements. Contributions of repetitive element transcription towards cancer initiation, and the mechanisms by which cancer cells evade lethal viral mimicry responses during tumor initiation remain poorly understood. In this report, we characterize premalignant lesions of the fallopian tube along with syngeneic epithelial ovarian cancer models to explore the earliest events of tumorigenesis following loss of the p53 tumor suppressor protein. We report that p53 loss permits transcription of immunogenic repetitive elements and chronic viral mimicry activation …

Computational Sensitivity Evaluation Of Ultrasound Neuromodulation Resolution To Brain Tissue Sound Speed With Robust Beamforming, Boqiang Fan, Wayne Goodman, Sameer A Sheth, Richard R Bouchard, Behnaam Aazhang

Faculty, Staff and Student Publications

Low-intensity focused ultrasound (LIFU) neuromodulation requires precise targeting and high resolution enabled by phased array transducers and beamforming. However, focusing optimization usually relies on phantom measurements or simulations with inaccurate acoustic properties to degrade neuromodulation resolution. Therefore, this work analyzes the sensitivity of neuromodulation resolution, measured by off-target activation area (OTAA), to brain tissue sound speed. A Robust Optimal Resolution (ROR) beamforming method is proposed to minimize the worst-case OTAA with restricted sound speed inaccuracy and propagation information estimated with deviated sound speed. The propagation estimation model utilizes equivalent source method (ESM) to map sound field between different acoustic parameter …

Identifiability And Model Selection Frameworks For Models Of High-Grade Glioma Response To Chemoradiation, Khushi C Hiremath, Kenan Atakishi, Ernesto A B F Lima, Maguy Farhat, Bikash Panthi, Mihir D Shanker, Sara Thrower, Jodi Goldman, Caroline Chung, Thomas E Yankeelov, David A Hormuth Ii

Faculty, Staff and Student Publications

We have developed a family of biology-based mathematical models of high-grade glioma (HGG), capturing the key features of tumour growth and response to chemoradiation. We now seek to quantify the accuracy of parameter estimation and determine, when given a virtual patient cohort, which model was used to generate the tumours. In this way, we systematically test both the parameter and model identifiability. Virtual patients are generated from unique growth parameters whose growth dynamics are determined by the model family. We then assessed the ability to recover model parameters and select the model used to generate the tumour. We then evaluated …

The Microbiome-Restorative Potential Of Ibezapolstat For The Treatment Of Clostridioides Difficile Infection Is Predicted Through Variant Polc-Type Dna Polymerase Iii In Lachnospiraceae And Oscillospiraceae, Ashok Kumar

Faculty, Staff and Student Publications

Ibezapolstat (IBZ), a first-in-class antibiotic targeting the PolC-type DNA polymerase III alpha-subunit (PolC) in low G + C bacteria, is in clinical development for the treatment of Clostridioides difficile infection (CDI). In the phase 2 trials, IBZ had potent activity against C. difficile while sparing or causing regrowth of Lachnospiraceae, Oscillospiraceae, and Erysipelotrichales, common commensal low G + C bacteria. The purpose of this study was to utilize in silico approaches to better interpret the narrower than expected IBZ spectrum of activity. IBZ susceptibility to human commensal microbiota was predicted using genomic analysis and PolC phylogenetic tree construction in relation …

Rapid Serial Visual Task Assessment Performance In Response To Training In A Central Vision Loss Model, Hrinmai Manikandan

Expo Student Presentations

2025 Spring Expo Poster Presentation

• Biological & Life Sciences
• Health Sciences & Health Professions

Investigating The Role Of Centromere Deletion In Chromosome Segregation, Azait Imtiaz, Rafael Contreras-Galindo

Expo Student Presentations

2025 Spring Expo Poster Presentation

• Health Sciences & Health Professions

The Ethics Of Gene Editing Hereditary Deafness, Jasmine Borie

Richard T. Schellhase Essay Prize in Ethics

Gene editing has been a hot topic of interest in the field of science, and many gene editing solutions for heritable diseases are in the works. In most cases, gene editing is done with good intentions, but there are some instances where it would not be favorable for reasons that may not be inherently obvious to everyone. Several forms of deafness and hearing loss can be inherited, meaning that it can be passed down from parent to offspring. Curing hereditary deafness using gene editing may seem like a good idea, but it can lead to unintentional discrimination and further stigmatization …

Research Day 2025 Program, Western Michigan University Homer Stryker M.D. School Of Medicine

Research Day

No abstract provided.

My Oath Of Healing And Living, Samuel B. John Mph

be Still

No abstract provided.

Adipose Injectable Filler With Use Of Meshed Dermal Matrix And Porcine Urinary Bladder Matrix For The Management Of A Complex Achilles Wound, Francois M. Lokenye Dpm, Orlexia Thomas Dpm, Mariam Kamil Bs, Lady Paula Dejesus Dpm, Facfas, Facpm, Dwsp

Posters

Chronic Achilles wounds present a significant clinical challenge due to limited vascularity, high mechanical stress, and the complex anatomy of the posterior lower leg.

Regenerative medicine offers a promising alternative to traditional wound management through the use of advanced biologic materials.

This case highlights a novel approach utilizing a combination of adipose-derived injectable filler, acellular dermal matrix, and porcine urinary bladder matrix to enhance tissue regeneration, provide structural support, and promote wound healing.

1st Place Contest Entry: Effectiveness Of Intravesical Bcg In The Treatment Of Nonmuscle Invasive Bladder Cancer: An Umbrella Review, Gerald Obinna Ozota

Eric M. Scandrett Graduate Library Research Prize

This is Gerald Obinna Ozota's submission for the 2025 Eric M. Scandrett Graduate Research Prize, which won first place. It contains their essay on using library resources, their bibliography, and a summary of their research project on conducting a systematic literature search to identify all relevant systematic reviews and meta-analyses investigating the effectiveness of intravesical Bacillus Calmette-Guerin (BCG) on Non-muscle-invasive Bladder Cancer (NIMBC).

Gerald is a student in the Ph.D. in Pharmaceutical Sciences program at Chapman University. Their faculty mentor is Dr. Lawrence Brown.

Redefining Cancer Photodynamic Therapy With Gold Nanoparticles, Zoey A. Lockwood, Michael R. Jirousek, James P. Basilion, Clemens Burda

Faculty Scholarship

Despite advancements made in treatment options, cancer continues to be one of the leading causes of death worldwide. Photodynamic therapy (PDT) has gained attention as a minimally invasive and highly selective treatment option for cancer. However, challenges due to the hydrophobicity of photosensitizers and their poor tumor selectivity have limited their use in cancer therapy. Recent developments in nanotechnology, particularly the use of gold nanoparticles (AuNPs), help overcome these challenges. AuNPs provide a stable and biocompatible platform to deliver photosensitizers, improving their solubility, stability, and ability to target tumors while reducing side effects. Functionalized AuNPs take advantage of mechanisms like …

Development Of A Self-Management Tool For Individuals With Seizure Clusters: Trial Design And Methodological Report, Molly Mcvoy, Eytan Hirsch, Luisa Londono, Kari Colón-Zimmermann, Jin Seok Cho, Martha Sajatovic

Faculty Scholarship

Background: Despite advances in anti-seizure medications (ASMs) for people with epilepsy (PWE), adverse outcomes, negative health events (NHEs), and breakthrough seizures remain common. Rescue medication (RM) can better manage repetitive seizures, but barriers to RM use persist. Self-management for PWE and a history of NHEs (SMART) is an evidence-based epilepsy self-management program aimed at reducing barriers and maximizing facilitators to self-care in high-risk PWE. Methods: This 2-phase, ongoing clinical trial adapts SMART to integrate RM support for PWE with repetitive seizures. Phase 1, now completed, used input from an advisory board (AB) of PWE, caregivers, and clinicians to adapt the …

Analyzing Social Media Trends In Cosmeceuticals: Insights From Google Trends And Tiktok Analytics, E. Correia, Jenna Mandel, Stephanie R. Jackson Cullison

Department of Dermatology and Cutaneous Biology Faculty Papers

OBJECTIVE: Social media usage has surged, particularly since the COVID-19 pandemic. Dermatology invokes intense interest on social media, and cosmeceuticals are among the most trending topics, offering a unique space for dermatologists to share their expertise. By using tools like Google Trends and TikTok viewership, we aim to capture cosmeceutical trends to guide dermatologists' educational efforts.

METHODS: A Google Trends search from January 2004 to December 2023 was performed on retinol, bakuchiol, salicylic acid, glycolic acid, azelaic acid, hydroquinone, niacinamide, vitamin C serum, and hyaluronic acid. Trend lines were created for each term, and yearly percent differences in relative search …

Achieving Total Health Using Food To Heal: A Podcast On A Holistic Approach To Nutrition, Taylor Sharer

Senior Theses

Nutrition is the key to a healthy and happy life. In a world where chronic, avoidable diseases are the leading cause of death, it is necessary to educate the public on how they can improve their overall health and wellbeing using food. Every aspect of health is interconnected, and what we eat can create massive changes in our health. My project focuses on holistic nutrition, providing an easily accessible, science-based and informative discourse about how to reach health and wellness goals through a podcast. Using personalized experience combined with current research, I discuss topics such as whole foods, individualized nutrition, …

Early Motor And Language Development In Infants At Elevated Likelihood For Autism, Natalie C. Deal

Senior Theses

During the early stages of infant development, various emerging skills set the foundation for more complex abilities. One such connection is the development of motor skills, which play a crucial role in influencing language outcomes later in the infants' first year. Although these developmental cascades are well understood in typically-developing populations, less is known about the cascade in infants at elevated likelihood for autism spectrum disorder (ASD). Many infants who are later diagnosed with ASD have motor delays or language delays, suggesting that the cascade from motor to language may not be typical in this population. Additionally, little is known …

Physiological Indicators Of Social Anxiety In Preschoolers With The Fragile X Premutation, Olivia Cyburt

Senior Theses

The Fragile X premutation (FXpm) is a common genetic disorder often characterized by psychiatric impairments, including anxiety. It results from a trinucleotide repeat expansion (CGG) of 55-200 repeats on the FMR1 gene. Despite its association with psychiatric symptoms, there is limited research regarding the relationship between FXpm and anxiety, particularly social anxiety. Early detection of social anxiety is essential for timely intervention, yet it remains challenging to identify in young individuals with FXpm due to limited research. The present study aimed to bridge this gap by examining social anxiety in preschoolers with the FXpm, utilizing both a physiological and behavioral …

Exploring The Impact Of Pharmacy Education On Pharmacy Residents' Confidence & Knowledge Of Gender-Affirming Hormone Therapy, Grace Thompson, Jordan Ballou, Chao Cai

Senior Theses

This thesis will examine the relationship between pharmacy school education about gender-affirming hormone therapy and the confidence and knowledge of PGY1 and PGY2 pharmacy residents at ASHP-accredited or candidate pharmacy residency programs across the United States. This cross-sectional study was completed through an analysis of de-identified survey data, including demographics, confidence-based questions, and knowledge-based questions. The study survey and thesis were compiled by reviewing the current literature regarding the perceptions of pharmacists, pharmacy residents, and student pharmacists on transgender and gender diverse topics. The survey was sent to pharmacy residents through residency program directors (RPDs) and program contacts. After considering …

The Structural Inequality Of Status Quo Clinical Communication, Joelle Robertson-Preidler

Faculty and Staff Publications

No abstract provided.

Priorities For Research, Education, Clinical Practice, And Policy From The Long Covid Physio International Forum, Kiera Mcduff, Darren A. Brown, Douglas P. Gross, Mark A. Faghy, Todd E. Davenport, Jennifer Audette, Laura Bassi, Michelle Bull, Saul E. Cobbing, Simon Décary, Alison Flynn, Flic Jeyes, Cara Kaup, Malissa Martin, Etienne Ngeh, David Putrino, André Saravia, Asya Shiloff-Rogers, Helen Skiffington, Lindsay Skipper, Julia M. Vogel

Pacific Faculty Work

Purpose: Long COVID Physio (LCP) is an international peer support, education and advocacy, patient-led association of physiotherapists living with long COVID and allies. In 2022, LCP hosted an international forum. One of the aims of the forum was to identify priorities in long COVID and rehabilitation. Methods: We conducted an international consultation on priorities for long COVID and rehabilitation with people living with long COVID, clinicians, researchers, and other key interest-holders (referred to collectively as “consultants”) who registered for and attended the LCP International Forum. We collected feedback from consultants using web-based questionnaires, the Zoom chat from the forum, and …

Nsu Kpcom Link - Spring 2025 - Volume 4.1, Nova Southeastern University

NSU Florida Link Newsletter

No abstract provided.

Switzerland’S Approach To Combating Addiction To Opiates, And Its Application To The United States Framework, Vittoria Volpi

Switzerland: Global Health and Development Policy

The opioid epidemic remains a pressing global public health challenge, with a hypothesized 1.2 million opioid-related fatalities in the United States alone, by 2029 (Rao et al., 2021). In the United States, the epidemic was driven by the overprescription of opioid pain medications in the 1990s. In contrast, in Switzerland, the opioid crisis stemmed from heroin imports and open-air drug scenes in the late 20th century. This research project analyzes Switzerland's national response to opioid abuse—specifically its Four Pillar Approach—and evaluates its potential applicability within the context of the United States. Using a qualitative research design, the study draws on …

Standardizing Social Determinants Of Health Factors From Heterogeneous Sources To Improve Data Fairness, Yifang Dang

Dissertations and Theses (Open Access)

Social Determinants of Health (SDoH) significantly influence health outcomes, yet their representation in computational models remains fragmented. This dissertation addresses this gap by constructing an SDoH ontology (SDoHO), leveraging it to improve large language model (LLM) performance, and using LLMs to extract new knowledge and enrich the ontology. The overarching goal is to establish a feedback loop where ontology development enhances LLM-based extraction, and LLM-derived insights refine and expand the ontology. The methodology is structured across three aims: (1) ontology construction, (2) ontology-assisted LLM enhancement, and (3) LLM-driven ontology enrichment, with a focus on Alzheimer’s Disease and Related Dementias (ADRD). …

Dean's Update, April 2025, Neil W. Schluger

SOM Dean's Research Newsletter

No abstract provided.

Building Bridges Of Knowledge, Cuny Innovative Teaching Academy (Cita)

Open Educational Resources

Building Bridge of Knowledge (BBK) is a CUNY-wide faculty fellowship project, aiming to help students use generative artificial intelligence (AI) tools ethically, responsibly, and effectively. Funded by Lumina Foundation in 2024-25, the project was executed by the CUNY Innovative Teaching Academy (CITA) of the Office of Faculty Affairs at CUNY Central Office, with 25 Faculty Fellows in five disciplinary areas (Education, Health, Humanities, Social Sciences, and STEM) chosen from across CUNY’s senior and community colleges. Each disciplinary cohort was led by a CUNY faculty member with expertise in the use of AI. The final materials, described and linked in this …

Computer-Aided Integrated Rehabilitation For Post-Stroke Patients Using Deep Learning Techniques, Kaichen Tang

Dissertations and Theses (Open Access)

Stroke is a leading cause of long-term disability, often requiring intensive rehabilitation and frequent clinical assessments such as the Fugl-Meyer Assessment. However, traditional in-person evaluations are resource-heavy and difficult to scale, limiting access for many patients. Additionally, monitoring vital signs like blood pressure and oxygen saturation typically depends on specialized equipment, leading to fragmented care and incomplete recovery insights. Even when assessments and monitoring are available, patients often struggle to maintain high-quality, intensive exercise routines without supervision, further limiting rehabilitation outcomes.

To address these challenges, this dissertation proposes an AI-driven, smartphone-based framework that integrates automated motor function assessment, non-invasive vital …

Search, The Jackson Laboratory

Search Magazine

No abstract provided.