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Acute Effects Of Phenytoin And Thioridazine, Alone And Combination, Upon Water Intake And Body Weight Changes In Rats, Miriana Witzig-Krstic

Masters Theses

Concommitant medication of anticonvulsants and psychotropics appears to be predominant among mentally retarded, geriatric, and psychiatric in- and out-patient populations. Despite suggested interaction and toxicity resulting from such combination treatment, substantial data remains unavailable. This study was designed to explore effects of dual treatment of thioridazine

Mental Health Status Of Malay Students At U.S. Colleges And Universities, Md. Shuaib Che Din

Dissertations

The basic premise of this study was that foreign students are faced with problems during much of their stay in the United States. It was the purpose of this study to determine the effects of everyday life strains on the mental health status of Malay students at U.S. colleges and universities. Specifically, this study looked at the relationships between the symptoms of psychiatric disorders of depression, psychological coping resources of self-esteem and self-mastery, and the background variables. Also this study attempted to determine the levels of depression, self-esteem, and self-mastery; the manifestation of the depressive symptoms according to the domains …

Commencement Program 1984 (Summer Conferring Of Degrees), Loma Linda University

Commencement Programs

CONTENTS

3 | The Academic Procession

4 | Conferring of Degrees

6 | Candidates for Degrees

14 | Awards

Effects Of Dentin Chips, Hydroxyapatite, And Demineralized Dentin As Apical Plugs, D. Wylie Brandell

Loma Linda University Electronic Theses, Dissertations & Projects

Two mm plugs of demineralized dentin, hydroxyapatite, or dentin chips were condensed into the apical perforations of 48 anterior teeth of eight adult cynamolgus monkeys. The remainder of the canals were obturated with gutta percha and Grossmans sealer using lateral condensation technique. The degree of hard tissue formation and inflammation was evaluated at three and six months. No significant changes were noted between various materials at three months. However, after six months, the samples with apical plugs of hydroxyapatite had more hard tissue formation and less inflammation than others.

Extrathyroidal Human Biochemistry Of Monoiodotyrosine, Stanley Andrew Tan

Loma Linda University Electronic Theses, Dissertations & Projects

The existence of extrathyroidal monoiodotyrosine (MIT) has been debated because of uncertain results from measuring serum MIT. The reason is that the isotopic and chromatographic assays used have not been sensitive enough. This investigation undertook to establish the existence of MIT in serum utilizing a radioimmunoassay (RIA), to study the physiology of serum MIT, and to discover the pharmacologic effects of exogenous MIT.

MIT-binding antibody was raised in rabbits by immunization with an MIT-porcine thyroglobulin conjugate. The antiserum bound 40% of the labeled MIT at a final dilution of 1:1000. Incubation of 100 µ1 antiserum with 50 pg [^{125 …}

Physical Activity And Its Relationship To Life Satisfaction And General Health In The Elderly, Joan A. Hannicker Clay

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to Investigate the relationship between the level of physical activity and life satisfaction and general health in the elderly.

The null hypothesis stated there would be no relationship between levels of physical activity and life satisfaction, common ailments, and health perception in the elderly (alpha = 0.05). The study was a correlational survey using a convenience sample from four groups of elderly subjects.

Ordinal data was obtained through a health questionnaire administered to sixty subjects who met the criteria. Statistical analysis using chi-square found no relationship between the physical activity level and life satisfaction …

A Survey To Determine The Relationship Between The Elderly's And The Family’S Perception Of Aging, Paula M. Brubaker

MSN Research Projects

The purpose of this study was to determine the relationship between the elderly*s and family's perceptions of aging. The null hypothesis stated that when the elderly's and family's perceptions of aging were compared, as determined by scores on the "Perceptions about Aging" survey, there would be no significant difference at the .05 level. Data were collected from 60 subjects. Thirty were individuals age 65 and above, and 3 0 were non-elderly family members, one for each participant, who had had contact with the elderly subject at least once a week. All subjects were administered the "Perceptions about Aging" survey. The …

Effect Of Menstrual Cycle On Hedonic Response To Gustatory Stimuli, Laurie Ann O'Toole

Dissertations and Theses

The present experiment was conducted to determine the relationship between the human menstrual cycle and gustatory hedonic response. Hedonic response was defined as the perceived pleasantness or unpleasantness of a taste stimulus. Gender differences in taste hedonic have been observed; these may be due to differences in endocrine systems. Animal taste preferences are altered when reproductive hormonal status is experimentally manipulated. Previous researchers report that human females' hedonic responses to sucrose vary systematically with phase of menstrual cycle.

Jefferson Alumni Bulletin – Volume Xxxiii, Number 4, Summer 1984

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XXXIII, Number 4, Summer 1984

Jefferson scene, Page 2

44x2+40=Reunion 1984, Page 12

Reunion clinics, Page 19

Class notes, Page 37

Metabolism In Preimplantation Mouse Embryos, Harry M. Weitlauf, Gary L. Nieder

Neuroscience, Cell Biology & Physiology Faculty Publications

The ability of preimplantation mouse embryos to utilize glucose oxidatively is controlled, in part at least, at the level of glycolysis. Various experimental observations are reviewed that indicate the regulatory mechanism in delayed implanting blastocysts involves the classic negative allosteric feedback of high levels of ATP on phosphofructokinase while the situation in 2-cell embryos appears to be more complicated. That is, in addition to the usual negative effect of ATP and citrate on phosphofructokinase, there appears to be a modification of hexokinase that prevents phosphorylation of adequate amounts of glucose and results in low levels of fructose-6-phosphate at the 2-cell …

The Effects Of Tri-O-Cresyl Phosphate On 2',3'-Cyclicnucleotide-3'-Phosphohydrolase Activity In Neural And Non-Neural Tissue Of The Rat, Mark K. Schlager

Chemistry & Biochemistry Theses & Dissertations

A total of 44 Long-Evans rats received 5.7 g/kg tri-O-cresyl phosphate (TOCP) orally every 3 days for 6 days. A second group of 13 rats received 4.6 g/kg orally every 3 days for 6 days. Animals were administered atropine sulfate (10 mg/kg) intraperitoneally every 6 hours or as needed to alleviate cholinergic symptoms. Ten control animals were given corn oil orally. Eight rats (18%) survived the 5.7 g/kg dose regimen and 5 rats (38%) survived the 4.6 g/kg dose regimen. Surviving rats were killed at 30-33 days post-dose. Signs of delayed neuropathy included ataxia and motor impairment.

The CNP activity …

Two-Dimensional Electrophoretic Studies Of Normal Spematozoal Proteins, Ying Lin

Chemistry & Biochemistry Theses & Dissertations

Protein profiles of human spermatozoa have been mapped by using high resolution two-dimensional electrophoresis which combines isoelectric focusing as the first dimension and polyacrylamide gradient gels electrophoresis in SDS as the second dimension. The profiles of normal spermatozoa! extraction, acrosomal extraction and seminal plasma showed high resolution in its separation capability. No qualitative or quantitative differences were observed by using Coomassie Brilliant Blue R-250 staining in a much higher concentration of proteins. However, coomassie blue lacks the sensitivity to detect many minor components. Therefore, a silver staining procedure was used, which resulted in greatly increased sensitivity.

Samples from normal fertile …

The Effects Of Family Influence On Contraceptive Use Among Adolescents, Gladys Marie Davis Hill

MSN Research Projects

This was a descriptive correlational study designed to determine if there was a relationship between adolescent contraceptive use and family communication. The null hypothesis stated that there would be no significant correlation in the adolescent use of contraceptive methods and family communication. A researcher-designed tool, the "Adolescent Contraceptive Questionaire," was administered to 27 college students aged IS and 19 years. Of this group there were 3 whites and 24 blacks. The hypothesis was tested using the Pearson r correlation coefficient. There was no significant relationship between the adolescent's contraceptive use and family communication. The researcher failed to reject the null …

Immunology Of The Acquired Immunodeficiency Syndrome, Patrick W. Mclaughlin, Carl B. Lauter

Henry Ford Hospital Medical Journal

The Acquired Immunodeficiency Syndrome (AIDS) first recognized in 1981, has been extensively studied, and the most recent studies have demonstrated that its defects extend well beyond the apparent deficient cell-mediated immunity to include humoral immunity, autoimmunity, and abnormal immunoregulation. The recent discovery of a retrovirus, HTLV III, as a possible etiologic agent is discussed in relation to other viruses known to cause immunodeficiency. Simian AIDS, an animal model of virus-induced immunodeficiency, is also discussed. Recommendations are made regarding the interpretation and limitations of immune testing in AIDS, including a discussion of how apparently healthy homosexuals and groups at risk develop …

Santa Clara Magazine, Volume 26 Number 8, Summer 1984, Santa Clara University

Santa Clara Magazine

2 - ALBEE'S ST. GEORGE AND THE DRAGON By Michael Tueth, S.J. Some principles of archetypal criticism are applied to Albee's Who's Afraid of Virginia Woolf?

7 - NUCLEAR ADDICTION Edmund G. Brown Jr. The United States and the Soviet Union are engaged in an addictive and ultimately lethal process. Neither will break out of the curse of assured mutual destruction.

9 - GIVE US THIS DAY OUR DAILY BREAD By Charles E. French. There are good reasons today to hope for a solution to world hunger, one that will occur in our time.

13 - TRAITS OF A HEALTHY …

Infectious Diseases And The Persisting Microbial Challenge, Louis D. Saravolatz

Henry Ford Hospital Medical Journal

No abstract provided.

Prospects For The Medical Use Of Interferon In 1984, Bosko Postic, Julio C. Arroyo

Henry Ford Hospital Medical Journal

Interferon, a natural and wide spectrum antiviral polypeptide that was discovered in 1957, has been extensively described. In addition to its antiviral effect, interferon has been found to suppress tumor growth and modulate the immune response. Until 1980, interferon was primarily prepared for clinical trials in human leukocytes derived from the buffy coat of whole blood. A major breakthrough occurred in the late 1970s when human interferon was produced by DNA recombinant methods in such heterologous cells as bacteria (genetic engineering). Interferon is not commercially available in 1984, but it may, based on clinical trials in humans, become part of …

Clinical Trials: I. Design And Ethical Issues, Barbara Tilley

Henry Ford Hospital Medical Journal

No abstract provided.

Commencement Program 1984, Loma Linda University

Commencement Programs

CONTENTS

2 | 1984 Events of Commencement

3 | Academic Procession

4 | The Speakers

7 | The Honorees

Order of Program

• School of Medicine, 12
• Graduate School, 18
• School of Dentistry, 23
• School of Nursing, 29
• School of Education, 32
• College of Arts and Sciences, 38
• School of Allied Health Professions, 45
• School of Health, 50

The Effects Of Maternal Administration Of Methadone On Beta-Endorphin Content In The Brain And Pituitary Of The Rat Progeny, Randall L. Braun

Loma Linda University Electronic Theses, Dissertations & Projects

Methadone is often used in the maintenance and detoxification of opioid-dependent pregnant women. This use of methadone during pregnancy is known to be associated with teratogenic effects observed in the progeny. The present study is an attempt to gain insight into possible pathophysiologic mechanism(s) responsible for these teratogenic effects: specifically, a relationship between maternal methadone administration and the content of the endogenous opioid peptide, beta-endorphin, in the brain and pituitary of the rat progeny.

In brief, nulliparous mature female Sprague-Dawley rats received daily injections (5 mg./kg.) of methadone hydrochloride (methadone-treated) or a similar volume of physiological saline (controls), treatment started …

Third Molar Eruption Prediction, Michael L. Jacobsen

Loma Linda University Electronic Theses, Dissertations & Projects

The diagnosis and treatment of third molars has often been cited as a special problem to the orthodontist. If the prognosis of third molars could be determined, orthodontic treatment could progress on a more positive basis.

This study was designed to provide a method of deciding whether developing third molars will erupt or become impacted.

Records from 130 orthodontically treated cases of Dr. Fredsall⁸ were studied. Several factors were evaluated and measured using the patients' cephalometric radiographs.

The actual fate of the third molars were recorded in the hope it could be used to predict what to expect from …

The Effect Of Dietary Alpha - Linolenic Acid On Apparent Risk Factors Of Cardiovascular Disease, Kelvin D. Lindbeck

Loma Linda University Electronic Theses, Dissertations & Projects

Eight healthy male lacto-ovo-vegetarian subjects averaging 28.0 ± 3.6 years of age (22 to 53 years) were fed a diet rich in α-linolenic acid (18:3 ω 3) for four weeks. Arterial blood pressure and body weight were recorded each week. Plasma 6-keto-prostaglandin F_1α (6-keto- PGF_1α ), thromboxane B₂ (TXB₂), total cholesterol, triglyceride, and total phospholipid fatty acid composition were analyzed at 0, 2 and 4 weeks.

Systolic blood pressure increased significantly between weeks 0 and 1 (106.5 ± 2.7 mmHg to 114.0 ± 3.7 mmHg; p < 0.003), but decreased to 107.3 t 2.6 mrHg (p < 0.02) at week 2. There was an insignificant increase in both systolic and diastolic blood pressures after four weeks. There was no significant change in either total cholesterol or triglyceride levels during the four weeks.

Plasma 6-keto-PGF_1α levels increased significantly from 60.13 ± …

Lesions Induced In Rodent Pancreas By Azaserine And Other Pancreatic Carcinogens, Daniel S. Longnecker

Dartmouth Scholarship

Focal proliferative changes in the acinar cells of the pancreas of rats have been induced by several systemically administered carcinogens including azaserine, N-nitrosobis(2-oxopropyl)amine, N-nitroso-(2-hydroxypropyl) (2-oxopropyl)amine, and N delta-(N-methyl-N-nitrosocarbamoyl)-L-ornithine (MNCO). Foci, nodules, and adenomas induced by these carcinogens are usually made up of atypical-appearing acinar cells that maintain a high degree of differentiation, but a minority of these lesions exhibit anaplastic cellular changes that suggest the development of malignant potential. Such anaplasia may occupy the whole of smaller lesions or may occur as a secondary focal change within larger nodules or adenomas. Many foci and nodules per pancreas have been induced …

A.V. Black Interview (1) Conducted On May 24, 1984 About The Boonshoft School Of Medicine At Wright State University, A. V. Black, James St. Peter

Boonshoft School of Medicine Oral History Project

In this first of three interviews, Dr. A.V. Black, former Chairman of the Montgomery County Medical Society and former faculty member of the Community Medicine Department of the Wright State University School of Medicine, discusses his early background and experiences as a physician in the Miami Valley area. He describes his wartime activities and his involvement in the Montgomery County Medical Society.

Dr. Black then discusses briefly the initial reaction of the Medical Society to the invitation of study of the feasibility of establishment of a School of Medicine in Dayton.

Alteration Of Gallium Biodistribution Using Indium Complexes For Enhanced Early Imaging, John W. Triplett

Pharmaceutical Sciences Faculty Patents

Radiopharmaceutical compositions and methods for tumor tomography in mammals are disclosed, wherein radioactive gallium and non-radioactive indium are injected into said mammals whereby the affinity of said radioactive gallium for non-tumor tissues is decreased, resulting in enhanced imaging characteristics.

Chemiosmotic Properties Of Isolated Secretory Granules From Parotid Glands Of Normal And Isoproterenol Treated Rats, Peter Raymond Arvan

Yale Medicine Thesis Digital Library

Secretory granule fractions were prepared isoosmotically from the parotid glands of normal rats and from rats that had received repeated injections of isoproterenol. These granules, purified extensively, are stable after isolation, making it possible to study biophysical parameters which may relate to their role in intracellular transport and secretion.Normal parotid granules have an internal pH of (TURN)6.8 and a low ionic permeability with respect to internal buffering capacity. By contrast, granules from the treated rats have an internal pH ranging from (TURN)7.7 in (0.3 M) sucrose media to (TURN)7.1 in (100 mM) KCl media; suggesting a large ionic permeability with …

Human Need Fulfillment Alteration In The Client With Uterine Cancer: The Registered Nurses' Perception Versus The Clients' Perception, Linda Lane Lilley

Ellmer School of Nursing Theses & Dissertations

This study was a comparison of the similarities and differences between the registered nurses' perception and clients' perception of human need fulfillment alterations in the client with uterine cancer. The effect of level of educational preparation and number of years work experience on the nurses' perception was also analyzed. The participants were 15 registered nurses and 15 clients who had uterine cancer and were admitted to two acute care hospitals in Tidewater. Registered nurses were asked to complete the tool entitled Human Needs Assessment Scale and rate the 35 human needs in relation to the perceived importance for the client. …

Detailed Description And Nomenclature Of High Resolution G-Banded Horse Chromosomes And Cytogenetic Analysis Of Hereditary Multiple Exostosis In Horses, Alma Maciulis

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

A reliable technique for obtaining late prophase, prometaphase and greater numbers of metaphase chromosomes is presented. The increased number of mitoses and high resolution chromosomes were obtained using a modification of the typical three-day blood culture technique in which the cell cycle was temporarily blocked at the G₁-s border with methotrexate. A high resolution G-band idiogram is presented using a system similar to the standardization of human chromosomes. The use of this technique and system of nomenclature will facilitate routine analyses of horse chromosomes and provide a basis for the identification and recording of chromosome aberrations in this …

Protein Recovery And Coagulation Properties Of Commercial And Fractionated Milk Clotting Enzymes, Khalida A. Shaker

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Protein recovery and coagulation properties of five commercial and fractionated milk clotting enzymes were studied. The fractionated enzymes were Sephadex G-100 fractions of the commercial enzymes. Milk clotting activity of each fraction was tested using Berridge substrate. All fractions from each preparation which had milk clotting activity as measured with the Formagraph were collected and pooled. These samples and the original enzyme preparations were used to coagulate milk. Percent of protein lost in whey was determined by Kjeldahl. Coagulation was followed using a spectrophotometer monitoring changes in apparent absorbance at 600 nm. Curd protein yields using the five original enzyme …

Survival Of Porcine Pepsin During Cheddar Cheese Making And Its Effect On Casein During Cheese Ripening, Gheyath H. Majeed

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

A modification of a linear diffusion test for measuring milk clotting enzymes at concentrations of 1 x 10^-4 to 1 x 10^-1 chymosin units/ ml was developed to permit quantitative assay of porcine pepsin in Cheddar cheese with a standard deviation of 6%. The amount of porcine pepsin retained in Cheddar cheese curd was dependent on pH of milk at setting. Milk at pH 6.6, 6.4, 6.2, and 6.0 was set with porcine pepsin, acidified with lactic acid and glucono-~-lactone and made into Cheddar cheese. After pressing the corresponding curd contained 0, 3.64+0 .12 %, 4.79+0.52%, and 5.94+0.30% …