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Low Toxicity Radiation Sensitizer, Barton L. Bergquist, James C. Chang

Patents (University of Northern Iowa)

Bis(5-aminofluorescein)dichloroplatinum(II), and substituted fluoresceinamine derivatives of this compound are disclosed as highly effective radiation sensitizers which enhance the effect of ionizing radiation on tumor cells, but uniquely do so without the usual accompanying high toxicity level to surrounding normal cells. A direct combination, single step reaction synthesis is disclosed for preparing bis(5-aminofluorescein)dichloroplatinum(II) from the reaction between an alkali metal tetrachloroplatinate(II) and 5-aminofluorescein.

Dr. Edward J. Spanier Interview (1) Conducted On December 10, 1984 About The Boonshoft School Of Medicine At Wright State University, Edward J. Spanier, James St. Peter

Boonshoft School of Medicine Oral History Project

This is the first in a series of interviews with Dr. Edward J. Spanier, former Assistant Director of Health Affairs Planning and former Assistant Dean for Administration in the Wright State University School of Medicine. He served as Assistant Vice President for Financial Services, and Treasurer of Wright State University.

In this initial interview, Dr. Spanier discusses his background prior to coming to Wright State University and his first years in the College of Science and Engineering here. Dr. Spanier talks about his initial responsibilities as developer of the initial School of Medicine planning proposal, and of the early stages …

Animals In Testing: How The Cpi Is Handling A Hot Issue, Anonymous

Popular Press Items

No abstract provided.

Linkage Data Excluding A Locus For Multiple Endocrine Neoplasia Type 2 Syndromes From The Distal Part Of The Short Arm Of Chromosome 11, Kenneth K. Kidd, Susan D. Kruger, Daniela S. Gerhard, Judith R. Kidd, David Housman, Joseph M. Gertner

Henry Ford Hospital Medical Journal

A study designed to identify the location of a gene for multiple endocrine neoplasia type 2 (MEN-2) is being performed using a single large family segregating for MEN-2A. Here we report our initial results using a set of DNA restriction fragment length polymorphisms spanning a 40 cM segment of the short arm of human chromosome 11. The locus for MEN-2 in this family is excluded from this entire region which includes an oncogene, c-Ha-ras-1, two hormone loci, insulin and parathyroid, and the five hemoglobin genes in the beta hemoglobin gene duster. This is the first exclusion of such a large …

Impact Of Screening On Prognosis In The Multiple Endocrine Neoplasia Type 2 Syndromes: Natural History And Treatment Results In 105 Patients, Margareta Telenius-Berg, Bertel Berg, Bertil Hamberger, Sten Tibblin, Lars-Erik Tisell, Lars Ysander, Gunnar Welander

Henry Ford Hospital Medical Journal

We evaluated the effects of screening for multiple endocrine neoplasia type 2A (MEN-2A) in 12 families. Genealogical studies going back to 1730 show a common ancestry for seven Swedish families and one American family. The total number of patients included 105 individuals, 68 of whom were diagnosed by our screening program. Our screening methods for medullary carcinoma of the thyroid (MTC) had an optimal sensitivity and specificity. The frequency of gene carriers detected in MEN-2A families was 55%. Screening will lead to early diagnosis and early therapy, which in turn, will significantly decrease morbidity, incidence of surgical complications, and mortality …

Research Vistas In The Multiple Endocrine Neoplasia Syndromes, John J. Mulvihill

Henry Ford Hospital Medical Journal

Progress in understanding the single gene, cytogenetic, and multifactorial traits that predispose to human cancer suggests possible new directions for research in the multiple endocrine neoplasia (MEN) syndromes. Among the other 200 or so monogenic disorders associated with human neoplasia, advances have come from further delineation of syndromes by various clinical specialists, the recognition of subtypes of syndromes previously thought to be homogeneous, the search for in vitro manifestations of the mutant gene in fibroblasts, and the establishment of cell, tissue and patient registries and of voluntary lay organizations to serve as advocates for the disease. With regard to cytogenetics, …

The Molecular Basis Of Polypeptide Hormone Production By Medullary Thyroid Cancer, C. J. M. Lips, P. H. Steenbergh, J. W. M. Höppener, J. Zandberg, H. S. Jansz

Henry Ford Hospital Medical Journal

Using recombinant DNA techniques, we analyzed the structure of human calcitonin (CT)-encoding DNA. The sequence of nucleotides derived from the messenger RNA (mRNA) predict the amino acid sequence of the entire human CT precursor protein. The complete CT gene could be isolated from a DNA library of the human genome. The CT precursor encoding sequences (exons) as well as the noncoding intervening sequences (introns) could be identified. Another sequence, called human calcitonin gene-related peptide (hCCRP), could be located near this CT-encoding DNA. A genomic fragment encoding hCCRP was used as a probe to detect and isolate the corresponding mRNA in …

Speech Results Following Modified Pharyngeal Flap Surgery, Karen S. Zalewski

Masters Theses

It is the purpose of this study to provide a descriptive analysis of 13 patients who have undergone a modified pharyngeal flap surgery completed by one plastic surgeon. Variables associated with the speech of these individuals were based on four measures, including a questionnaire, the Iowa Pressure Articulation Test, the screening portion of the Templin-Darley Test of Articulation, and listener ratings of audio-taped post-surgical speech samples.

Of the eight subject variables studied, two variables were found to be closely associated with speech results. These variables included number of surgeries performed on subjects and number of years in speech therapy. The …

Research Issues Surrounding Holocaust Survivors: Adaptability And Aging, Benjamin J. Hodgkins, Richard L. Douglass

The Journal of Sociology & Social Welfare

The thesis of this article is that, in spite of a large body of literature on the subject, a significant need exists for sociological research on the long-term consequences of the trauma experienced by survivors of Nazi concentration camps. Most of what is known about the adjustment of Holocaust survivors is based upon limited case histories of survivors who sought psychiatric aid, or requested assistance in qualifying for indemnification payments from the German government. The social and psychological dynamics of successful adjustment to life after the traumatic Holocaust experience by the majority of survivors has largely been ignored. Reasons for …

A Quantitative Study Of The Distinctive Proteins Of The Eosinophil: A Comparison Of Normals And Eosinophilic Patients, James M. Olson

Honors Theses

Eosinophils have long been associated with parasitic and allergic diseases. Methods of procurement and purification of eosinophils in the last ten years have allowed intensive investigation into their components, properties, functions, and mechanisms (Gleich et al, 1982). The goals of this project are to separate eosinophils in blood samples taken from patients with eosinophilia and from normals based on density over distontinuous Metrizamide gradients; to determine quantitatively the levels of the three distinctive proteins of the eosinophil, specifically MBP, EDN, and ECP; and to compare the levels of these proteins found in eosinophils of patients with eosinophilia to the amounts …

The Role Of The Salivary Glands In Uptake Of Fluoride In Teeth And Bone, Robin E. Vance

Loma Linda University Electronic Theses, Dissertations & Projects

The cariostatic capability of fluoride is generally recognized, in addition, it may also have a beneficial effect on bone. Fluoride is thought to exercise its cariostasis through a local effect on teeth, however, the possibility exists that fluoride exerts its action through a systemic mechanism. Fluoride uptake by rat teeth and its effectiveness as a cariostatic substance was studied in parotidectomized, submaxillariectomized, and totally sialoadenectomized animals (both parotid and submaxillary glands removed). The uptake of fluoride in bone was also quantitated for comparison purposes.

Rats were injected daily with 15 micromoles of fluoride dissolved in 0.1 ml saline. The rats …

Regulation Of Luteinizing Hormone And Catecholamine Release, Benjamin Aaron Adler

Theses and Dissertations (ETD)

These studies tested the interrelated hypotheses that the ovarian hormones produce their positive feedback effects on luteinizing hormone (LH) secretion through activation of noradrenergic and adrenergic systems in specific hypothalamic regions. Furthermore, the ovarian hormones may alter the activity of opioid neuropeptide and Gamma-Aminobutyric Acid (GABA) systems to produce these alterations in catecholamine transmission and gonadotropin secretion. Radioimmunoassays were utilized to determine plasma LH and median eminence LHRH, and hypothalamic catecholamine concentrations were measured by radioenzymatic assay.

The first two studies tested whether epinephrine (EPI) synthesis inhibition blocks the accumulation of median eminence LHRH that precedes the ovarian hormone-induced LH …

Parenting Skills Of Primiparas As Correlated To Maternal Age, Kristine Grow Johnson

MSN Research Projects

A descriptive study was designed to examine parenting skills of primiparas and determine if parenting skills correlated with maternal age. The researcher hypothesized that there would be no significant difference between maternal age and scores as determined by the Parenting Skills Questionnaire and the Observation of Parenting Skills. Primiparas, ranging in age from eighteen to thirty-three, comprised three samples : ten in the eighteen to twenty-three age group, ten in the twenty-four to twenty-nine age group, and three in the thirty to thirty-five age group. Parenting knowledge and skills were assessed of subjects with infants three to seven days old. …

Dr. Robert D. Reece Interview (2) Conducted On November 7, 1984 About The Boonshoft School Of Medicine At Wright State University, Robert D. Reece, James St. Peter

Boonshoft School of Medicine Oral History Project

This is a second in a series of interviews with Dr. Robert D. Reece, Associate Professor and Chairman of the Department of Medicine in Society in the Wright State University School of Medicine. In this interview Dr. Reece continues his discussion of various aspects of the development of his department and of the School of Medicine.

In the first portion of the interview Dr. Reece continues his examination of the development of the curriculum of his department. In specific, Dr. Reese looks at the Weekend Intervention Program: its development by Dr. Harvey Segal; its operations; and its success.

The second …

What's Happening: November 7, 1984, Maine Medical Center

What's Happening

No abstract provided.

Genetics And Epidemiology Of Gallbladder Disease In New World Native Peoples, K M Weiss, R E Ferrell, C L Hanis, P N Styne

Faculty, Staff and Student Publications

Native peoples of the New World, including Amerindians and admixed Latin Americans such as Mexican-Americans, are highly susceptible to diseases of the gallbladder. These include cholesterol cholelithiasis (gallstones) and its complications, as well as cancer of the gallbladder. Although there is clearly some necessary dietary or other environmental risk factor involved, the pattern of disease prevalence is geographically associated with the distribution of genes of aboriginal Amerindian origin, and levels of risk generally correspond to the degree of Amerindian admixture. This pattern differs from that generally associated with Westernization, which suggests a gene-environment interaction, and that within an admixed population …

Dr. Robert D. Reece Interview (1) Conducted On October 31, 1984 About The Boonshoft School Of Medicine At Wright State University, Robert D. Reece, James St. Peter

Boonshoft School of Medicine Oral History Project

This is the first in a series of interviews with Dr. Robert D. Reece, founding Chairman of the Department of Medicine in Society in the Wright State School of Medicine. In this first interview, Dr. Reece discusses the early development of the department and how it impacts the medical student.

In the first part of the interview Dr. Reece discusses his education and background prior to coming to Wright State University. He also recalls the discussions leading to the establishment of the Department of Medicine in Society within the School of Medicine. Dr. Reece then examines the development of the …

Dr. William D. Sawyer Interview (2) Conducted On October 8, 1984 About The Boonshoft School Of Medicine At Wright State University, William D. Sawyer, James St. Peter

Boonshoft School of Medicine Oral History Project

In this second interview Dr. William D. Sawyer, Dean of the Wright State University School of Medicine, continues his discussion of his background prior to coming to Wright State University. He compares medical education development between Thailand and the United States and his move back from Thailand to Indiana University in the United States. Dean Sawyer then goes on to describe his tenure as Chairman of the Department of Microbiology/Immunology at the School of Medicine at Indiana University.

Dean Sawyer discusses his administrative and leadership style at Indiana University and his challenges as Chairman.

In the third part of the …

Dr. William D. Sawyer (1) Interview Conducted On October 3, 1984 About The Boonshoft School Of Medicine At Wright State University, William D. Sawyer, James St. Peter

Boonshoft School of Medicine Oral History Project

In this first interview with Dr. William D. Sawyer, Dean of the Wright State University School of Medicine, Dean Sawyer discusses his background prior to coming to Wright State University. In particular, Dr. Sawyer's medical education; his internship and residency; his military service and service at Johns Hopkins University are examined.

In further discussions, Dean Sawyer turns to his experiences in Thailand as a member of the Rockefeller Foundation developing the Department of Immunology and Microbiology at Bangkok University. Dean Sawyer discusses the development process and its impact on his own leadership style.

Inhibition Of T Lymphocyte Mitogenesis By 1,25-Dihydroxyvitamin D3 (Calcitriol)., William F.C. Rigby, Terryl Stacy, Michael W. Fanger

Dartmouth Scholarship

Recent studies have suggested that vitamin D may have other important biologic activities in addition to its well-characterized role in the maintenance of calcium homeostasis. Discovery of cytosolic receptors for vitamin D in human peripheral blood monocytes and lectin-stimulated lymphocytes prompted us to study the effects of 1,25-dihydroxyvitamin D3 (calcitriol), the most biologically active metabolite of vitamin D, upon phytohemagglutinin (PHA)-induced lymphocyte blast transformation. We have found that calcitriol is a potent inhibitor of PHA-induced lymphocyte proliferation, achieving 70% inhibition of tritiated thymidine incorporation after 72 h in culture. Furthermore, calcitriol suppressed interleukin-2 (IL-2) production by PHA-stimulated peripheral blood mononuclear …

Digest Of The Philadelphia College Of Osteopathic Medicine (Fall 1984), Philadelphia College Of Osteopathic Medicine

Digest

The Fall 1984 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• PCOM's Fifth President
• Mayor Proclaims Osteopathic Medicine Week
• Honoring Galen S. Young, DO
• Founders Day/Alumni Weekend Schedule
• Meet the Class of 1988
• Beth Mulvihill
• Living a Dream
• DO Wins Award
• Philadelphia Fair
• Fighter Doc Earns Medal
• News from the OMCP
• Faculty Notes
• Alumni News Briefs
• New Appointments
• In Memoriam
• Synapsis Ad

Negative Cooperatively In The Binding Of 3-Aminopyridine Adenine Dinucleotide To L-Α-Glycero-3-Phosphate Dehydrogenase, David Wheeler

Chemistry & Biochemistry Theses & Dissertations

Glycerol-3-phosphate dehydrogenase catalyzes the reversible reaction:

NAD⁺ + G-3-P ⇌ NADH + DHAP + H⁺

The enzyme is found in organisms from E. coli to man. The primary function of the enzyme varies from organism to organism. Depending on the metabolism of the organism, the enzyme may function primarily to generate G-3-P for lipid (in organisms with a highly aerobic biosynthesis metabolism), or it may function primarily to produce NAD⁺ to support glycolysis. Complex multicellular organisms possess tissue specific isozymes of GPDH whose kinetic parameters reflect the relative importance of G-3-P and NAD⁺ production in various …

Computer-Assisted Methods For Design Optimization Of Cardiac Bioprosthetic Valves, Mohamed S. Hamid, Hani N. Sabbah, Paul D. Stein

Henry Ford Hospital Medical Journal

Excessive mechanical stresses on valvular leaflets are considered an important factor in the degeneration of cardiac porcine bioprosthetic valves. This study describes a computer-assisted numerical model of a bioprosthetic valve which estimates the magnitude and distribution of leaflet stresses. The study also describes our initial attempts to determine the influence of stent height upon leaflet stresses. Whereas lowering stent heights has been suggested to improve hemodynamics in the bioprosthetic valve region, results indicate that an increase in leaflet stresses can accompany reductions of stent height.

Automating The Expertise Of The Neuropsychologist, Kenneth M. Adams, Gregory G. Brown

Henry Ford Hospital Medical Journal

No abstract provided.

Computer Applications In The Vascular Registry Of Henry Ford Hospital: Use Of A Simplified Access Method, Joseph P. Elliott Jr., Kunwar Kapoor, John G. Hageman, D. Emerick Szilagyi, Roger F. Smith, Michalene Mcpharlin

Henry Ford Hospital Medical Journal

The Vascular Registry of Henry Ford Hospital was initiated by one of the authors in 1957 to provide a consistent and accurate method of documenting and correlating the clinical results of the treatment of occlusive and aneurysmal arterial diseases. Data collection for each patient includes demographic information, treatment of clinical problems, and followup observations. Initially, the system consisted of keypunch cards and eventually magnetic tape processing. By 1980, it was necessary to further update the system because of the increase in patient volume, the need to minimize manual manipulations, and the demand for research data. The present system uses institutional …

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Book Reviews Of Moral Clarity In The Nuclear Age By Michael Novak -- Our Right To Choose: Toward A New Ethic Of Abortion By Beverly Wildung Harrison -- The Death Decision: Eight Experts Address The Legal And Ethical Issues Emerging On The Frontier Of Today's New Biology Edited Leonard J. Nelson -- Challenge To Love: Gay And Lesbian Catholics In The Church Edited By Robert Nugent, Catholic Physicians' Guild

The Linacre Quarterly

No abstract provided.

Chemical Protection Against Ionizing Radiation, John C. Livesey, Donald J. Reed, Lucile F. Adamson

School of Pharmacy Faculty Books and Book Chapters

The scientific literature on radiation-protective drugs is reviewed. Emphasis is placed on the mechanisms Involved in determining the sensitivity of biological material to ionizing radiation and mechanisms of chemical radioprotection. In Section 1, the types of radiation are described and the effects of ionizing radiation on biological systems are reviewed. The effects of ionizing radiation are briefly contrasted with the effects of non-Ionizing radiation. Section I reviews the contributions of various natural factors which influence the inherent radiosensitivity of biological systems. Included in the list of these factors are water, oxygen, thiols, vitamins and antioxidants. Brief attention is given to …

What's Happening: August 1, 1984, Maine Medical Center

What's Happening

No abstract provided.

The Effects Of Alprazolam And Triazolam On Two Methods Of Induced Aggression In Rats, Howard Kiel Plummer

Masters Theses

Two new benzodiazepine tranquilizers, alprazolam and triazolam were used to try to reduce aggression in rats produced by isolation or drugs. Both reduced elements of isolation-induced aggression, and triazolam was more potent. Little reduction was found in drug-induced aggression by either tranquilizer. It is unknown why aggression was not reduced for the drug-induced method, but it is possible that a synergism existed between the two methods of inducing aggression, since the same rats were used for both methods. Different rats were used for each tranquilizer. Reduction in aggression for the isolated rats seems consistent with results for other benzodiazepine tranquilizers.