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Oncolog, Volume 36, Issue 04, October-December 1991, Stephen S. Kroll M.D., James M. Bowen Phd

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Antisense RNA technology successfully blocks K-ras-induced cancer
• Immediate breast reconstruction reduces the trauma of mastectomy
• The human face of data

Instrumentation And Control For A Microprocessor-Based Coronary Perfusion System, Daniel L. Priester

Master's Theses (1922-2009) Access restricted to Marquette Campus

No abstract provided.

Statistical Interpretation Of Dna Typing Data, R Chakraborty

Faculty, Staff and Student Publications

No abstract provided.

High Performance Liquid Chromatographic Separation Of Different Types Of Collagen, Yongjoo Chung

Chemistry & Biochemistry Theses & Dissertations

The objective of this research was to develop a method for the separation of different types of collagen using a large pore size (100 nm) reversed-phase C-8 column. Three different types of collagen (type I, III, and V) were sufficiently separated on the column using a mobile phase containing water-acetonitrile-trifluoroacetic acid. Collagens found in each HPLC peak were identified using sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) to assay the column effluents.

Trifluoroacetic acid (TFA) was used as an ion pair reagent. This compound improved the chromatographic profile for these proteins on a reversed-phase column. It was observed that with …

Osteoinductivity Of Demineralized Bone: A Quantitative In Vitro Assessment, Yihong Zheng

Biological Sciences Theses & Dissertations

Acid demineralized bone (DMB) implanted in extraosseous sites induces bone formation. In vivo studies have shown that DMB stimulates the differentiation of mesenchymal cells into osteogenic cells. In this study an in vitro system was developed to demonstrate the osteoinductivity of DMB quantitatively. This in vitro working system was used to assess the osteoinductivity of variously processed DMB products as a means to evaluate their processing protocols. A human dermal fibroblastic (HDF) cell line was initiated from tissue explants as a working model, along with a human periosteal (HPO) cell line as a control. Ground DMB processed by LifeNet Transplant …

The Role Of Gaba In Reproductive Neuroendocrine Systems, Robert Carter Mcree

Theses and Dissertations in Biomedical Sciences

Local gamma-amino butyric acid (GABA) neurons in the hypothalamus can modulate the luteinizing hormone releasing hormone (LHRH) pulse generating system.

Two animal models (intact and ovariectomized rats) were used to determine the nature of modulation of LHRH release by GABA. The experiment determined the release of LHRH, serotonin (5-HT), and 5-hydroxyindole acetic acid (5-HIAA) during two hormonal states with each model. In the intact rat the proestrus and estrus states were examined, and in the ovariectomized rat in-vitro release was determined with (OVX₂) and without (OVX) estradiol treatment.

In-vivo experiments studied the effect of stimulation of GABA receptors …

Transplantation Of The Mammalian Pineal Gland: Studies Of Survival, Revascularization, Reinnervation And Recovery Of Function, Wutian Wu

Theses and Dissertations in Biomedical Sciences

The survival, revascularization, reinnervation, and recovery of function of transplanted newborn rat pineal glands were studied following grafting into four different locations in pinealectomized rats. These locations were the third cerebral ventricle, in situ (where the pineal gland is normally located), the renal capsule, and the anterior chamber of the eye.

Pinealocytes in the grafts maintained high metabolic activity as evidenced by the presence of euchromatic nuclei, prominent nucleoli, infolded nuclear envelopes, numerous mitochondria and Golgi apparati, and relatively abundant endoplasmic reticulum and ribosomes. In addition, morphological correlates of two putative secretory processes were observed in the grafts. The first …

Lac+ Saccharomyces Cerevisiae, Robert C. Dickson, Kotikanyadanam K. Sreekrishna

Molecular and Cellular Biochemistry Faculty Patents

The invention relates to novel, transformed strains of Lac⁺ Saccharomyces cerevisiae, capable of utilizing lactose as a sole carbon source, produced by inserting into the Saccharomyces cerevisiae a plasmid containing a lactose permease and a beta-galactosidase gene derived from Kluyveromyces lactis yeast.

Update - September 1991, Loma Linda University Center For Christian Bioethics

Update

In this issue:

-- Business and Medicine: Are They Ethically Compatible?

-- [ A Standard Level of Health Care to All: A Moral Obligation? ]

-- Loma Linda University reorganizes the Center for Christian Bioethics

Psychological Factors Relevant To The Prehospital And In-Hospital Phases Of Acute Myocardial Infarction, Lori W. Kenyon, Mark W. Ketterer, Richard C. Preisman

Henry Ford Hospital Medical Journal

Recognition and treatment of psychological factors relevant to the acute prehospital and in-hospital phases of myocardial infarction (Ml) are reviewed. Various emotions and personality characteristics can be both risk factors for and consequences of acute Ml. Components of the Type A behavior pattern and levels of somatic and emotional awareness have been linked with excessive treatment-seeking delay for Ml patients. Psychiatric conditions such as panic disorder may mimic symptomatic presentation of Ml and therefore have implications for differential diagnosis in the emergency room. Additionally. anxiety, depression, and neurobehavioral disorders such as delirium are relatively common during the hospitalization period and …

Beta-Adrenergic Blocking Agents In The Treatment Of Patients After A Myocardial Infarction, Sidney Goldstein

Henry Ford Hospital Medical Journal

Beta-adrenergic blocking agents have been widely used in ischemic heart disease. They have achieved their greatest benefit in the secondary prevention of recurrent events in patients following acute myocardial infarction (Ml). This is a review of the major clinical investigations exploring the effects of beta-adrenergic blocking agents in patients following acute Ml and in a variety of patient subsets. These data indicate that the routine use of beta-adrenergic blocking agents in postinfarction patients results in a 25% to 35% decrease in mortality and has increased relative and absolute benefit in patients with ventricular ectopy and left ventricular dysfunction. The adverse …

Recent Concepts In Clinical Psychiatry: Drug Treatment In Schizophrenia, Shahin H. Hussain

Department of Psychiatry

No abstract provided.

Caring For The Acute Myocardial Infarction Patient: A Nursing Perspective, Denise L. Crimaldi Adams, Sandra R. Perez

Henry Ford Hospital Medical Journal

Cardiac nursing is nearly 30 years old. Changes in the rote of cardiac nursing have directly corresponded to the three distinct medical phases of care for the acute myocardial infarction patient—arrhythmia detection, pump failure, and limiting infarct size. Nursing care delivery in the cardiac setting, the cardiac patient, and the role of the cardiac nurse each have undergone changes over the years, which together has provided a challenge to health care delivery. Future effects of technological and pharmacologic advances, social changes, and nursing professional practice issues on cardiac care delivery are imperative to consider as health care moves into the …

Translocation Of The Glucose Transporter Glut4 In Cardiac Myocytes Of The Rat., Jan W. Slot, Hans J. Geuze, Sander Gigengack, David E. James, Gustav E. Lienhard

Dartmouth Scholarship

The insulin-regulated glucose transporter GLUT4 was immunolocalized in rat cardiac muscle under conditions of basal and stimulated glucose uptake, achieved by fasting and a combined exercise/insulin stimulus, respectively. In basal myocytes there was very little (less than 1%) GLUT4 in the different domains of the plasma membrane (sarcolemma, intercalated disk, and transverse tubular system). GLUT4 was localized in small tubulo-vesicular elements that occur predominantly near the sarcolemma and the transverse tubular system and in the trans-Golgi region. Upon stimulation approximately 42% of GLUT4 was found in the plasma membrane. Each domain of the plasma membrane contributed equally to this effect. …

Sertoli Cell Only Syndrome (Secos): Lessons From Case Studies, Jamsheer J Talati, Hizbullah Sheikh

Section of Urology

Between June 85 and December 87, 69 testicular biopsies were submitted for histopathological examination during investigation of infertility; ten (14%) patients had a Sertoli cell only syndrome. The history, clinical features, and hormonal profiles were analyzed in an attempt to categorize these patients on aetiological basis. Two followed treatment of malignancy--one by radiation for testicular cancer and one by cyclophosphamide for a lymphoma. One had unilateral cryptorchidism. Mumps was etiological factor in one patient. FSH levels determined in 6 patients were elevated in all suggesting a possible dependence of (sick) Sertoli cells on spermatogenic cells for production of inhibin. Alternative …

Actinobacillus Pleuropneumoniae-Induced Thymic Lesions In Mice And Pigs, D.L. Stine, M.J. Huether, Rodney A. Moxley, Subramaniam Srikumaran

School of Veterinary and Biomedical Sciences: Faculty Publications

Actinobacillus pkuropneumoniae produces several hemolysins/cytotoxins that may be important in the pathogenesis of acute lesions. Little is known, however, about the role of these virulence factors in chronic disease or the carrier state. We investigated the effects of live bacterial infection and transthoracic injection of a sterile culture supernatant on primary lymphoid organs and lymphocyte populations. Transthoracic inoculation of mice or intranasal inoculation of pigs with virulent A. pleuropneumoniae serotypes 1 and 7 induced thymic cortical lymphoid necrosis. These lesions were reproduced in mice by transthoracic injection of a concentrated sterile culture supernatant. The cytotoxic effect of this culture supernatant …

Expression Of A Human Cartilage Procollagen Gene (Col2a1) In Mouse 3t3 Cells., Leena Ala-Kokko, James Hyland, Carol Smith, Kari I. Kivirikko, Sergio A. Jimenez, Darwin J. Prockop

Department of Medicine Faculty Papers

Expression in a recombinant system has been difficult to obtain for any of the major fibrillar collagens that require processing by eight or more post-translational enzymes. Here, two DNA constructs were designed so that the promoter region of the gene for the pro-alpha 1(I) chain of human type I procollagen drove expression of the human type II procollagen gene in mouse NIH 3T3 cells, a culture line that normally synthesizes type I procollagen but not any cartilage-specific protein such as type II procollagen. Both constructs were expressed as both mRNA and protein. In clones expressing the construct at high levels, …

Coping Styles Of Nurse Practitioners And The Effectiveness Of These Styles In Managing Stress, Carol J. Kolarik Smith

MSN Research Projects

The purpose of this descriptive correlational study was to identify the coping styles used by nurse practitioners and determine the effectiveness of these styles in managing stress. The Roy Adaptation Model for Nursing was the theoretical framework used for this study. The research question which guided the data collection was what are the coping styles of nurse practitioners and how effective are these styles in managing the stress relative to functioning in the expanded role of nurse practitioner? The sample of convenience consisted of 72 nurse practitioners from Mississippi (30) and Tennessee (42) who completed and returned the survey questionnaire. …

[Book Review Of] Ivf And Justice: Moral Social And Legal Issues Related To Human In Vitro Fertilization, By Teresa Iglesias, Joseph Boyle

The Linacre Quarterly

No abstract provided.

Reinforcement Effects On The I.Q. Scores Of Institutionalized Children And Adults With Developmental Disabilities, Jody Robin Lewis

Masters Theses

Eighteen institutionalized school-age and adult subjects with severe/profound developmental disabilities were evaluated for the effects of self-selected reinforcement for correct responding on their I.Q. scores when tested with the Stanford-Binet Intelligence Scale (Terman & Merrill, 1960) or the Leiter International Performance Scale (Arthur, 1952). Subjects were tested under both standard and reinforcement conditions. The results indicated that overall, subjects when tested under reinforcement conditions showed a significant increase in mean I.Q. scores when compared with the same subjects tested one month previously under standard conditions. Several features of the data reveal intriguing results with regard to subjects and related preexisting …

The Level Of Self-Confidence Related To Knowledge And Skills Of Nurse Clinicians Practicing In The Expanded Role, Myra E. Fitts

MSN Research Projects

The level of self-confidence attained in a particular role affects the ability to perform in that role. Self- confidence is not innate but is developed through the interactions and experiences one has. The purpose of this study was to identify the level of self-confidence related to knowledge and skills of nurse clinicians practicing in the expanded role. Benner’s (1984) framework. From Novice to Expert, provided the direction and structure for this descriptive study. Three hundred thirty- three nurse clinicians licensed to practice primarily in four southeastern states participated in this study. Data were collected using the Thibodeau/Hawkins Self-Assessment Scale and …

Reasons Community-Based Hospice Patients Require Hospitalization, Patricia Northcutt Stephens

MSN Research Projects

The philosophy of a community-based hospice program involves care of terminally ill patients in their homes. However, some patients do not remain at home and are hospitalized. This descriptive study was conducted to determine reasons community-based hospice patients require hospitalization. Orem's Theory of Self-Care and Theory of Nursing Systems provided the theoretical framework. A convenience sample of 9 hospice patient primary caregivers from a community-based hospice program in West Central Alabama participated. These caregivers provided care to 9 hospice patients over the age of 40 years who required hospitalization in 1990 and had since expired. During scheduled home interview visits, …

Self-Perceived Health Concerns Of Early, Middle, And Late Adolescents, Diane Baker

MSN Research Projects

The purpose of this descriptive study was to identify the self-perceived health concerns of early, middle, and late adolescents.

Phenylbutyl Nitrone Compositions And Methods For Prevention Of Gastric Ulceration, Robert A. Floyd, John M. Carney

Pharmacology and Nutritional Sciences Faculty Patents

Compositions containing PBN, or active derivatives thereof, in a suitable pharmaceutical carrier for administration to a patient, are disclosed for treating or preventing gastric ulceration caused by ingestion of non-steroidal anti-inflammatories. Based on animal studies, the dosage is in the range of 3 to 300 mg/kg and is administered prior to, simultaneously, or shortly after ingestion of the NSAID compound(s). In the preferred embodiment, the range is between 10 and 30 mg/kg, depending on the dosage unit required to protect the mucosa. The preferred method of administration is orally, alone or in combination with the non-steroidal anti-inflammatory. It is believed …

Santa Clara Magazine, Volume 33 Number 4, Summer 1991, Santa Clara University

Santa Clara Magazine

12 - GEORGE BUSH AND THE QUESTION OF STYLE The president's campaign strategists have had Bush play up the victory in the Persian Gulf and avoid talk of much else. By Rita Beamish '74

17 - MIND OVER MONEY Challenging accepted notions about how to make money in the stock market through research on the psychology of investing. By Kathryn Bold '81

20 - STRESS: THE DEMOCRATIC AILMENT From bricklayers to stock brokers, everyone is susceptible to stress. By Elizabeth Fernandez '79

24 - CHARLES LAMPKIN: ON THE LONG ROAD Remembering the actor and music man who was SCU's artist-inresidence …

Ua66/13 Newsletter, Issue #6, Wku Public Health

WKU Administration Documents

Newsletter created by and about WKU Public Health.

Female Condoms, An Urgent Need, Mary Guinan

School of Public Health Faculty Research

As of February 1991, more than 16,000 cases of AIDS in women had been reported in the United States, but the ". tidal wave of cases in women is yet to come. World Health Organization (WHO) estimates of the number of women infected with the human immunodeficiency virus (HIV) range from 1.5 million in Africa to I 00,000 in the United States. Within the next ten years, the majority of these women will develop AIDS and die. Some will live a bit longer, but all are eventually doomed to die prematurely. Most will not live to see their 40th year.

Ua66/13/3 Newsletter, Wku Public Health

WKU Administration Documents

Newsletter created by and about the WKU Public Health department.

Oncolog, Volume 36, Issue 03, July-September 1991, Emil J. Freireich Md, James M. Bowen Phd

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• From cell culture to clinical protocol: In cancer research, the goals of scientist and clinician converge New clinic treats depressed cancer patients
• Half-century of progress in leukemia research

Digest Of The Philadelphia College Of Osteopathic Medicine (Summer 1991), Philadelphia College Of Osteopathic Medicine

Digest

The Summer 1991 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• President's Perspective
• Two Highest Ranking Medical Officers Receive Honorary Degrees - Brig. Gen. Ronald R. Blanck & Rear Admiral Hugh P. Scott
• Second Career Dos are among PCOM's Outstanding Graduates
• Bright Future on the Horizon as Master Facility Plan Begins
• Tackling Tough Issues
• Osteopathic Medicine + Research = Challenging Career Path
• On Campus
• New Appointments
• Just Published
• Class Acts
• In Memoriam
• Coming Events