Digital Commons Network^™

Regulation Of Cellular Ca2+ By Yeast Vacuoles, Teresa Dunn, Kenneth Gable, Troy Beeler

Uniformed Services University of the Health Sciences

The role of vacuolar Ca²⁺ transport systems in regulating cellular Ca²⁺ was investigated by measuring the vacuolar Ca²⁺ transport rate, the free energy available to drive vacuolar Ca²⁺ transport, the ability of the vacuole to buffer lumenal Ca²⁺, and the vacuolar Ca²⁺ efflux rate. The magnitude of the Ca²⁺ gradient generated by the vacuolar H⁺gradient best supports a 1 Ca²⁺:2 H⁺ coupling ratio for the vacuolar Ca²⁺/H⁺ exchanger. This coupling ratio along with a cytosolic Ca²⁺ concentration of 125 nM would give a …

Age-Induced Adaptations To The Motor Unit, Andrew Mezsaros

Faculty Publications - College of Physical Therapy

No abstract provided.

Accessing Genomic Information For Nonmedical Purposes, George P. Smith Ii

Scholarly Articles

No abstract provided.

Genetic Determinism Or Genetic Discrimination, George P. Smith Ii

Scholarly Articles

The first part of this essay evaluates the contemporary focus of the genetic revolution seen as such through the Human Genome Initiative - a project which brings not only great hope for new advancements of genetic knowledge designed to control disease and minimize human suffering, but raises real fears of unabated invasions of personal privacy that in turn would lead to discrimination for those found to be genetically handicapped. The extent to which this central fear is justified or rational is justified within the present context of the Genome Initiative, together with the past practices of genetic screening, will then …

Selected Demographic Variables As Predictors Of Behavior Change Among Adolescents In A Residential Treatment Center, Paul Stoltzfus

Faculty Publications - Doctor of Psychology (PsyD) Program

Research has demonstrated that theories of coping resources can be clarified by delineating risk factors and protective factors. These factors modulate the impact of traumatic events and which predict treatment outcome. This research project selected variables, conceptualized as risk and protective factors, to predict behavioral changes of adolescents at Chehalem House, a residential treatment center. The predictor variables were gender, age, diagnoses, level of intellectual functioning, the occurrence of sexual abuse, and severity of sexual abuse . The behaviors selected as criterion variables were non-compliance, negative attention seeking, and passivity/depression. Statistically significant regression equations were derived : a positive correlation …

Expression And Function Of Fgf-4 In Peri-Implantation Development In Mouse Embryos, Daniel A. Rappolee, Claudio Basilico, Yogesh Patel, Zena Werb

Department of Obstetrics and Gynecology Research Publications

One of the earliest events in mammalian embryogenesis is the formation of the inner cell mass (ICM) and the subse- quent delamination of primitive endoderm. We have found that mRNA for fibroblast growth factor (FGF)-4, but not FGF-3, is expressed in preimplantation mouse blastocysts and that the FGF-4 polypeptide is present in ICM cells. ICM-like embryonal carcinoma cells and embryonic stem cells also express FGF-4. Conversely, differentiated embryonal carcinoma cells in the endoderm lineage express FGF-3, but not FGF-4 mRNA. Although mouse embryos expressed FGF-4 mRNA from the 1-cell stage, embryos cultured from the 2-cell through the blastocyst stage in …

Biological Determinism Or Genetic Discrimination, George P. Smith Ii

Scholarly Articles

No abstract provided.

Critical Overview Of Wound Care Modalities, Keith W. Hartnett

Physical Therapy Scholarly Projects

The purpose of this independent study is to explore Physical Therapy modalities used in adjunct to traditional wound management. There are many factors that influence the healing rate. A basic knowledge of the body's healing process is needed in order to understand the affects modalities have on the wound.

The key to wound management is the initial and constant assessment. The patient history, subjective information, and objective measure are critical to the etiology and progression of the wound, and will be discussed.

Modalities can accelerate wound healing. Mechanical and physiological effects of the different modalities will be explored. This study …

Low Back Pain, Jeff Large

Physical Therapy Scholarly Projects

Low back pain (LBP) is one of the most common disorders seen in the health care setting today. The cost of rehabilitation of LBP makes up a significant proportion of today's health care economy. Both physical and social factors have been associated with the etiology of LBP. Today's advanced diagnostic equipment has allowed the underlying pathologies of LBP to be better understood. In the past, different theories and techniques for rehabilitation have been utilized. Current rehabilitation of LBP has emphasized effective, cost-efficient prevention and education.

The purpose of this independent study is to research current theories of risk factors, pathologies …

The Efficacy Of Functional Assessments In Rehabilitation Medicine, Keith E. Swanson

Physical Therapy Scholarly Projects

Functional assessment in rehabilitation medicine is not a new concept. Functional assessment measures have, however, experienced increased usage. Health insurance companies and clinicians are now focusing on functional outcomes in addition to objective tests.

Certain measurement criteria must be satisfied before a measurement tool may be successfully implemented into the clinical setting. Variable standardization, reliability, and validity are necessary for accurate measurement. The term function, however, deals with many variables leading to definitional difficulty.

The purpose of the functional assessment is to describe, screen and assess, and monitor. Although many functional assessments are available for clinical use, most lack scientific …

A Critical Review Of The Human Immunodeficiency Virus (Hiv) Infection And The Most Common Clinical Manifestations Of Acquired Immune Deficiency Syndrome (Aids), Randy Willman

Physical Therapy Scholarly Projects

The purpose of this independent study is to review the viral and immunologic factors in human immunodeficiency virus (HIV) infection and present the clinical manifestations most commonly associated with acquired immune deficiency syndrome (AIDS). As physical therapists, we will thus increase our knowledge base of this complex disease and understand the many opportunistic infections associated with HIV infection and the various aspects of AIDS. In addition, by having a better understanding of the disease, we may overcome our fears, improve our personal attitudes toward patients with HIV/AIDS, and improve and prolong the quality of life of individuals with the disease.

Family Planning And Reproductive Health: Briefing Sheets For A Gender Analysis, Kirsten Moore, Debbie Rogow

Reproductive Health

This series of briefing sheets, developed by the Population Council, represents a starting point for the application of gender to the family planning (FP) and reproductive health (RH) arena. The information covers five key areas of RH: gender-based abuse, FP and gender issues among adolescents, sexuality and FP, men’s and women’s social and economic responsibilities for childrearing, and the complicated nexus between gender and FP/RH. In so doing, it provides a strong foundation for gender training. This concept was first developed to fulfill a need for gender training within the regional Operations Research/Technical Assistance Projects. To date, two such workshops …

Health Professions Division Catalog 1994-1995, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Review Of The P53 Tumor Suppressor Gene And Its Role In Gliomas, James Dearing Christian

Theses and Dissertations

The following review of the p53 tumor suppressor gene will be discussed with particular attention to its role in human gliomas, as well as the various advances that have brought this molecule to the forefront of cancer research. A review of tumorigenesis focuses on the molecular mechanisms that convey neoplastic characteristics upon a normal cell. It is discussed how the coordinate advances in chromosome analysis and molecular techniques enabled the p53 gene to be categorized as a "tumor suppressor gene" and applied to various forms of cancer, including colorectal and lung carcinoma. The focus of the review will be on …

Training Profiles Of Collegiate Swimmers: A Survey Of Ncaa Division I, Ii, And Iii Coaches About Their Male Freestyle Swimmers During The 1993-94 Swimming Season, Sean M. Cabbage

Masters Theses

The lack of information about how the majority of college swimming teams train encouraged the author to conduct the following study.

A cover letter and questionnaire, regarding training methods, were sent to all 377 NCAA men's swimming coaches (Division I, II, and III) in the United States, as listed in the 1993-94 NCAA Directory. Approximately 50 percent of all surveys were returned with an equal response rate from each of the respective divisions.

Questions regarded team division and size, the coaches experience level and recent training changes, months of peak training during the 1993-94 collegiate season, peak training volume and …

Frequency Of Attainment Of Plateau In Maximal Oxygen Consumption In Differentially Trained Athletes, Jeffrey Michael Seda

Masters Theses

A plateau in oxygen consumption during exercise testing has been considered a requisite indicator of achievement of true maximal oxygen consumption. The wide range of reported percentages of subjects revealing a plateau (7 to 80 percent) indicates that closer analysis of factors that may influence plateau attainment is necessary. This study examined the frequency of plateau attainment in two groups of differentially trained subjects. One group (TR) of 12 males (ages 18-36) were trained runners and the other group (WL) of 12 males (ages 18-31) consisted of trained weight lifters. The subjects participated in a series of maximal exercise tests …

Synapsis: Philadelphia Campus (1994), Philadelphia College Of Osteopathic Medicine

All Yearbooks

This yearbook includes Clubs, Dinner, Biking, Parties, Skits, Clinics, Trip, Halloween, Yearbook Staff, Student Council, Class Officers, American College of Family Physicians, American Medical Women's Association, AMWA, American Medical Student Association, AMSA, Big Brother/Big Sister Program, Undergraduate American Academy of Osteopathy, UAAO, Christian Medical & Dental Society, Christian Medical Society, Community of Italian American Osteopaths, CIAO, Association Of Military Osteopathic Physicians and Surgeons, AMOPS, Pediatric Society, Pediatrics Society, Emergency Medicine, Student Osteopathic Surgical Association, Daniel Wisely Surgery, Surgery, Emanuel Fliegelman Obstetrics and Gynecology, Student Research Committee, Internal Medicine, Obstetrics and Gynecology, Sports Medicine, American Osteopathic Academy of Sports Medicine, AOASM, …

Penetration Of Piperacillin/Tazobactam Into Gynecologic Tissues Following A Single Loading Dose Prior To Hysterectomy, William F. O'Brien, Shelley George

Obstetrics & Gynecology Faculty Publications

Objective: This study was undertaken to determine plasma and pelvic tissue concentrations of piperacillin/tazobactam following a single intravenous administration.Methods: Plasma and tissue samples were obtained following administration of 3 g of piperacillin and 0.375 g of tazobactam. Concentrations of these agents were determined by chromatography.Results: Plasma concentrations (mean ±SD) for piperacillin/tazobactam were 208 ± 87/27 ± 8 and 95 ± 53/14 ± 2, respectively, at 30 and 60 min after the start of the infusion. The 8:1 ratio between piperacillin and tazobactam in plasma remained constant for up to 96 min. Tissue concentrations yielded a broader range, but …

Outpatient Administration Of Paclitaxel, Siu Fun Wong

Pharmacy Faculty Articles and Research

Paclitaxel (Taxol®, Bristol-Meyers Squibb), anti neoplastic agent made from the bark of the Pacific yew tree, is undoubtedly one of the most exciting agents to be evaluated over the past decade. Paclitaxel has demonstrated significant promise against ovarian and metastatic breast cancer, and appears to be the most effective single agent to date for non-small-cell lung cancer in trials conducted by Eastern Cooperative Oncology Group (ECOG).

Oncolog, Volume 39, Number 02, April-June 1994, Vickie J. Williams, Kathryn L. Hale

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Outwitting unknown primary tumors
• Synthetic peptide effectively controls the spread of HIV in human cell cultures
• Biological response modifiers promising adjuvants to cancer therapy

Oncolog, Volume 39, Number 01, January-March 1994, Sunita Patterson, Maureen E. Goode, Kathryn L. Hale

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Liposomal muramyl tripeptide kills bone cancer cells by stimulating the immune system Gene therapy at M. D. Anderson
• Researcher studies the hemopreventive power of garlic

Oncolog, Volume 39, Number 04, October-December 1994, Linda N. Eppich, Maureen E. Goode, Kathryn L. Hale

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Looking for solutions to ethical problems in the clinic
• Interferon: the evolution of a biological therapy
• Colon cancer registry coordinates treatment, education, and research

The Role Of A Wildlife Reservoir In The Epidemiology Of Bovine Tuberculosis, D. U. Pfeiffer

Michigan Bovine Tuberculosis Bibliography and Database

The objective of this project was to study the epidemiology of bovine tuberculosis in the presence of a wildlife reservoir species. Cross-sectional and longitudinal studies of possum populations with endemic bovine tuberculosis infection were analyzed. The results were used to develop a computer simulation model of the dynamics of bovine tuberculosis infection in possum populations. A case-control study of breakdowns to tuberculosis infection in cattle herds in the Central North Island of New Zealand was conducted to identify risk factors other than exposure to tuberculosis in local possum populations.

The Specific Activities Of Shiga-Like Toxin Type Ii (Slt-Ii) And Slt-Ii-Related Toxins Of Enterohemorrhagic Escherichia Coli Differ When Measured By Vero Cell Cytotoxicity But Not By Mouse Lethality, Susanne W. Lindgren, James E. Samuel, Clare K. Schmitt, Alison D. O'Brien

Uniformed Services University of the Health Sciences

Characteristically, enterohemorrhagic Escherichia coli (EHEC) strains produce Shiga-like toxin type I (SLT-I), SLT-II, or both of these immunologically distinct cytotoxins. No antigenic or receptor-binding variants of SLT-I have been identified, but a number of SLT-II-related toxins have been described. Because EHEC 091:H21 strain B2F1, which produces two SLT-II-related toxins, is exquisitely virulent in an orally infected, streptomycin-treated mouse model (oral 50% lethal dose [LD₅₀], <10 >organisms), we asked whether the pathogenicity of strain B2F1 was a consequence of SLT-II-related toxin production. For this purpose, we compared the lethality of orally administered E. coli DH5α(Str^r) strains that produced …

Cytotoxic Necrotizing Factor Type 2 Produced By Virulent Escherichia Coli Modifies The Small Gtp-Binding Proteins Rho Involved In Assembly Of Actin Stress Fibers, Eric Oswald, Motoyuki Sugai, Agnès Labigne, Henry C. Wu, Carla Fiorentini, Patrice Boquet, Alison D. O'Brien

Uniformed Services University of the Health Sciences

Cytotoxic necrotizing factor type 2 (CNF2)produced by Escherichia coli strains isolated from intestinal and extraintestinal infections is a dermonecrotic toxin of 110 kDa. We cloned the CNF2 gene from a large plasmid carried by an Escherichia coli strain isolated from a lamb with septicemica. Hydropathy analysis of the deduced amino acid sequence revealed a largely hydrophilic protein with two peotential hydrophobic transmembrane domains. The N-terminal half of CNF2 showed striking homology (27% identity and 80% conserved residues) to the N-terminal portion of Pasteurella multocida toxin. Methylamine protection experiments and immunofluorescence studies suggested that CNF2 enters the cytosol of the target …

Does Hyperthermia Have A Therapeutic Role In Hiv Disease?, Linda M. Schecterle, John St. Cyr

Journal of the Minnesota Academy of Science

No abstract provided.

Diploma Nursing Students' Attitudes Toward Poverty, Elizabeth Louise Phillips

Masters Theses

According to King, stereotyped perceptions may interfere with nurse-client transactions. Therefore, nurses' should possess attitudes which enable them to care for individuals who live in poverty. A descriptive correlational design was used to examine first year and second year diploma nursing students' attitudes toward individuals living in poverty. It was hypothesized that second year diploma nursing students would demonstrate a more positive attitude toward those living in poverty than first year diploma nursing students.; A convenience sample of diploma nursing students (N = 102) completed the "Attitudes about Poverty and Poor Peoples" scale utilized to assess students' attitudes (Atherton et …

“Introduction” To Integrative Views Of Motivation, Cognition, And Emotion, William D. Spaulding

Department of Psychology: Faculty Publications

One of my formative experiences as a graduate student came during a break in our afternoon-long first-year proseminar. We had been discussing the scope of psychology, or rather, listening to two professors debate the scope of psychology. Both the protagonists were clinical psychologists by training, but one had remained an empirically focused social learning theorist, while the other had pursued the study of Eastern religion, psychoanalysis, and transpersonal psychology. As the class milled about, the social learning empiricist sought some closure on the discussion. "Dick," he said to his transpersonal colleague, "it seems to me that we disagree because in …

Trauma Patients: Social Support Desired And Perceived Satisfaction According To Category Of Provider, Marsha D. Stevens

Masters Theses

This study examined differences in social support received by trauma patients and their perceived satisfaction with the social support provided by various categories of providers including: family members, friends, RNs and other health professionals. Thirty hospitalized trauma patients were asked to rate the satisfaction they felt regarding seven forms of support. Types of support that most patients indicated their families and friends provided were spending time with them and making them feel important. Respectful treatment, providing information, encouragement and listening support from RNs and other health professionals was mentioned by a large percentage of the subjects. Qualitatively it was found …

Outlook Magazine, Spring 1994

Outlook Magazine

No abstract provided.