Digital Commons Network^™

Nutritional Requirements For Preterm Infants In Neonatal Intensive Care Units, James Allen Nelson

Theses and Dissertations - UTB/UTPA

This thesis reviewed the special caloric requirements of preterm infants. The goal of this research was to investigate the feasibility of using the time required for infants to reach substantial feeding as a possible indicator of future developmental progress. The triage of birth weight, gestational age, and days to first substantive oral feeding were highly significant in predicting development through 12 months of age. However, none of the independent variables contributed significant unique variance in predicting developmental outcome.

Jefferson Alumni Bulletin – Volume Xlvi, Number 1, December 1996

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLVI, Number 1, December 1996

Rational Drug Design, Page 4

Technology Transfer, Page 7

Clinical Trials, Page 9

World-Class Athletes and Drugs, Page 12

The Makings of the Complete Physician, Page 14

Major Alliance Links Jefferson with Mercy Health, Page 17

“Gene Repair” Corrects Mutation Leading to Disease, Page 19

Genetic Discoveries Lead to New Lung Cancer Tests, Page 20

Alumni Can Participate in JeffHOPE, Page 24

Student AMA Organizes Bone Marrow Drive, Page 25

Method And Compositions For Treating Age Related Disorders, John M. Carney, Robert A. Floyd

Pharmacology and Nutritional Sciences Faculty Patents

Compositions containing as the active ingredient a spin-trapping reagent, preferably α-phenyl butyl nitrone (PBN) or spin-trapping derivatives thereof, in a suitable pharmaceutical carrier for administration to a patient are disclosed for treating or preventing symptoms associated with aging or other conditions associated with oxidative tissue damage. Other spin-trapping agents can also be used, such as 5,5-dimethyl pyrroline N-oxide (DMPO) or α-(4-pyridyl 1-oxide)-N-tert-butylnitrone (POBN), and other spin-trapping derivatives thereof. These compositions and methods are useful in the treatment of age-related disorders, pre-surgical and/or pre-anesthetic preparation or administration of chemotherapeutic agents, and in the treatment of disorders or trauma of the brain, …

Helminths Of The Southwestern Toad, Bufo Microscaphus, Woodhouse's Toad, Bufo Woodhousii (Bufonidae), And Their Hybrids From Central Arizona, Stephen R. Goldberg, Charles R. Bursey, Keith B. Malmos, Brian K. Sullivan, Hay Cheam

Great Basin Naturalist

The gastrointestinal tracts, lungs, and urinary bladders from 77 Bufo microscaphus, 61 Bufo woodhousii, and 8 of their hybrids were examined for helminths. One species of trematode (Glypthelmins quieta), 1 species of cestode (Distoichometra bufonis), and 5 species of nematodes (Aplectana incerta, A. itzocanensis, Rhabdias americanus, Physaloptera sp., and Physocephalus sp.) were found. The greatest prevalence (41%) and mean intensity (231.7) were recorded for Aplectana incerta in Bufo woodhousii. It appears hybrids harbor fewer parasites than either parent species.

Ua12/2/1 College Heights Herald, Vol. 72, No. 26, Wku Student Affairs

WKU Administration Documents

WKU campus newspaper reporting campus, athletic and Bowling Green, Kentucky news.

Regular features include:

• Just a Second
• Campus Line
• For the Record / Crime Reports
• People Poll
• Sports
• Diversions
• Movie Reviews
• Classifieds

Articles in this issue:

• LaBelle, Charboneé. Restrooms: Americans with Disabilities Act Cuts Through Red Tape
• Leonard, Kim. Ride Plan Set to Begin
• Stamper, John. December Graduates Will Have Lots of Elbow Room
• Hall, Jason. All Hours Must be Completed
• Student Government Association Didn’t Miss the Bus with Resolution
• McDonner, Michael. Labs Wrongly Used
• Browning, Michelle. Meat-centered Diet is Unhealthy One
• VanWinkle, Cara. Dorm Life Offers Little Discipline
• Latham, …

Nonparaphilic Sexual Addiction, Mark Kahabka

The Linacre Quarterly

No abstract provided.

Cellular Basis Of Decreased Immune Responses To Pneumococcal Vaccines In Aged Mice, Manju Garg, Wei Luo, Alan M. Kaplan, Subbarao Bondada

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Previously, model systems were developed in our laboratory to study murine immune responses to the 23-valent pneumococcal polysaccharide vaccine Pnu-Imune, both in vivo and in vitro (M. Garg and B. Subbarao, Infect. Immun. 60:2329-2336, 1992; M. Garg, A. M. Kaplan, and S. Bondada, J. Immunol. 152: 1589-1596, 1994). Using these systems, we found that aged mice did not respond to the vaccine in vivo or in vitro. Cell separation studies showed that the unresponsiveness of the aged spleen cells to the vaccine was not due to an intrinsic B-cell defect or to T-cell-mediated immunosuppression but resulted from an accessory cell …

Helper Woman: A Biography Of Elinor Delight Gregg, Jacqueline S. Pflaum Dnsc, Mph, Ms

Dissertations

The intent of this investigation was to conduct an extensive study of the life and character of Elinor Gregg (1886-1970) in order to identify the contributions she made to professional nursing and to humanity. Nurse, educator, administrator, beloved relative, and friend, Elinor Gregg was an outstanding person whom nurses today might well emulate. Historical method provided the context for the study. Data were collected from the National Archives; National Library of Medicine Historical Section; Nursing Archives at Mugar Library, Boston University; Nursing Archives at Simmons College; National Headquarters of the American Red Cross; Archives of Colorado College; and Archives of …

Glanzmann Thrombasthenia. Cooperation Between Sequence Variants In Cis During Splice Site Selection., Ying Jin, Harry C. Dietz, Robert A. Montgomery, William R. Bell, Iain Mcintosh, Barry Coller, Paul F. Bray

Cardeza Foundation for Hematologic Research

Glanzmann thrombasthenia (GT), an autosomal recessive bleeding disorder, results from abnormalities in the platelet fibrinogen receptor, GP(IIb)-IIIa (integrin alpha(IIb)beta3). A patient with GT was identified as homozygous for a G-->A mutation 6 bp upstream of the GP(IIIa) exon 9 splice donor site. Patient platelet GP(IIIa) transcripts lacked exon 9 despite normal DNA sequence in all of the cis-acting sequences known to regulate splice site selection. In vitro analysis of transcripts generated from mini-gene constructs demonstrated that exon skipping occurred only when the G-->A mutation was cis to a polymorphism 116 bp upstream, providing precedence that two sequence variations …

The Product Of The Saccharomyces Cerevisiae Rss1 Gene, Identified As A High-Copy Suppressor Of The Rat7-1 Temperature-Sensitive Allele Of The Rat7/Nup159 Nucleoporin, Is Required For Efficient Mrna Export, Veronica Del Priore, Christine A. Snay, Andre Bahr, Charles N. Cole

Dartmouth Scholarship

RAT7/NUP159 was identified previously in a screen for genes whose products are important for nucleocytoplasmic export of poly(A)+ RNA and encodes an essential nucleoporin. We report here the identification of RSS1 (Rat Seven Suppressor) as a high-copy extragenic suppressor of the rat7-1 temperature-sensitive allele. Rss1p encodes a novel essential protein of 538 amino acids, which contains an extended predicted coiled-coil domain and is located both at nuclear pore complexes (NPCs) and in the cytoplasm. RSS1 is the first reported high-copy extragenic suppressor of a mutant nucleoporin. Overexpression of Rss1p partially suppresses the defects in nucleocytoplasmic export of poly(A)+ RNA, rRNA …

What's Happening: October 2, 1996, Maine Medical Center

What's Happening

No abstract provided.

Vital Signs, Fall 1996, Boonshoft School Of Medicine

Vital Signs

A twenty four page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

Attachment Of Toxoplasma Gondii To Host Cells Is Host Cell Cycle Dependent., Jane Grimwood, Jose R. Mineo, Lloyd H. Kasper

Dartmouth Scholarship

The initial attachment of Toxoplasma tachyzoites to target host cells is an important event in the life cycle of the parasite and hence critical in the pathogenesis of this infection. The efficiency of Toxoplasma attachment to synchronized populations of Chinese hamster ovary cells and bovine kidney cells was investigated by using a glutaraldehyde-fixed host cell assay system. For both cell lines, parasite attachment increased as the synchronized host cells proceeded from the G1 phase to the mid-S phase and then decreased as the cells entered the G2-M boundary. Postulating that these differences in attachment reflect the upregulation of a specific …

The Chironian Vol. 113 Fall/Winter 1996, New York Medical College

The Chironian

No abstract provided.

Newsletter: The Center For Professional Ethics, Fall 1996, Case Western Reserve University

Center for Professional Ethics

Table of Contents:

• Director's Corner by Robert P. Lawry
• 1525 - CPE Summer Ethics Fellowship Program Off to a Great Start
• The 1996 1525 - CPE Summer Ethics Fellows
• Dennis F. Thompson Visits Campus
• News & Notes

Opposing Motor Activities Are Required For The Organization Of The Mammalian Mitotic Spindle Pole, Tirso Gaglio, Alejandro Saredi, James B. Bingham, M Josh Hasbani, Steven R. Grill, Trina A. Schroer, Duane A. Compton

Dartmouth Scholarship

We use both in vitro and in vivo approaches to examine the roles of Eg5 (kinesin-related protein), cytoplasmic dynein, and dynactin in the organization of the microtubules and the localization of NuMA (Nu-clear protein that associates with the Mitotic Apparatus) at the polar ends of the mammalian mitotic spindle. Perturbation of the function of Eg5 through either immunodepletion from a cell free system for assembly of mitotic asters or antibody microinjection into cultured cells leads to organized astral microtubule arrays with expanded polar regions in which the minus ends of the microtubules emanate from a ring-like structure that contains NuMA. …

Case Studies Of Selective Mutism In Hispanic Children, Colleen Anne Gittins

Theses and Dissertations - UTB/UTPA

Selective mutism is a consistent refusal to use spoken language in specific social situations. This can occur in a particular environment or with specific individuals. A collaboration of four case studies was used to study the possible etiologies, characteristics, and intervention strategies associated with selective mutism. Four children from public school campuses in the Lower Rio Grande Valley of Texas were subjects in this investigation as well as teachers and parents.

A questionnaire was used to gather data along with informal interviews. Results concluded that prevalence rates for selective mutism are relatively high in the area surveyed. Furthermore, many professional …

Real-Time Visual Speech Articulation Training Aid, Neiyer S. Correal

Electrical & Computer Engineering Theses & Dissertations

A real-time visual articulation training aid has been implemented. It provides instantaneous visual feedback of vowel and stop-consonant production on a computer screen. The vowel training system corresponds to an improved floating-point implementation of a previous fixed-point system developed by Beck (1992). The new implementation provides better accuracy and an approximate five-fold increase in speed. Acoustic features computed from global short-time spectral shape are used for classification of vowels. Temporal spectral trajectories timed to begin with burst onset are used for stop consonants. A neural network is used to transform measurements of auditory stimuli from the feature space to a …

The Oral Health Status Of Individuals On Renal Dialysis, Kimberley Naugle

Dental Hygiene Theses & Dissertations

The purpose of this investigation was to perform oral assessments on individuals undergoing renal dialysis in Hampton Roads health care facilities to determine their oral health status. A purposive sample was identified via the Sentara Health System in Hampton Roads, from which individuals on renal dialysis who agreed to participate in the study were selected.

Three subgroups of the population were studied: those who have been on renal dialysis for less than a year, individuals on renal dialysis for one to three years and those on renal dialysis for longer than three years.

The Periodontal Disease Index by Ramfjord (1967) …

Passage Or Pathology: Current Attitudes Toward Women's Aging In The Literature Of Menopause, Kaaren Gearhart Ancarrow

Institute for the Humanities Theses

Menopause is currently portrayed in the medical literature as a pathological 11 process resulting from "hormone deficiency." However, feminist writers contend that the climacteric is part of the normal female aging process and oppose the medicalization of menopause and the consequent inevitable hormone replacement therapy (HR T) promoted by the hegemonic medical and pharmaceutical industries. This paper explores the historical development of these two paradigms of menopause and their manifestations in samples of three classes of contemporary literature on the subject: gynecological textbooks, popular advice books written by physicians, and women's accounts. Five major themes are investigated using quantitative and …

Apparatus And Method For Noninvasive Chemical Analysis, Robert A. Lodder

Pharmaceutical Sciences Faculty Patents

A method and apparatus are provided for magnetohydrodynamic acoustic-resonance, near-IR spectroscopy. The method includes a step of applying to a subject under study a magnetic field having a strength between 2,00-10,000 gauss, near-IR radiation having a wavelength between 800-3,000 nm and an acoustic wave having a frequency between 10 khz -1 Mhz. The method also includes the steps of inducing vibration of ions in the magnetic field and detecting an electric wave generated magnetohydrodynamically by the acoustic wave induced vibration of the ions. Next is the collecting of the electrical, acoustical and near-IR spectra and the analyzing of the collected …

Use Of L-Canavanine As A Chemotherapeutic Agent For The Treatment Of Pancreatic Cancer, Peter Crooks, Gerald A. Rosenthal

Pharmaceutical Sciences Faculty Patents

A pharmaceutical composition of canavanine, and a method treatment of cancer, particularly pancreatic cancer with L-canavanine is disclosed.

Current Issues In Rabies Prevention In The United States: Health Dilemmas, Public Coffers, Private Interests, Charles E. Rupprecht, Jean S. Smith, John Krebs, Michael Niezgoda, James E. Childs

Zoonotics and Wildlife Disease: Publications

Over the last 100 years, rabies in the United States has changed dramati~ally. More than 90% of all animal rabies cases reported annually to the CDC now occur in wildlife, whereas before 1960 the majority were in domestic animals. The principal rabies hosts today are wild carnivores and bats infected with several viral variants. Annual human deaths have fallen from more than a hundred at the turn of the century to one to two per year despite major outbreaks of animal rabies in several geographic areas. Modem day prophylaxis has proven nearly 100% successful; most human fatalities now occur in …

Identification And Characterization Of The Thrombin Binding Sites On Fibrin, David A. Meh, Kevin R. Siebenlist, Michael W. Mosesson

Biomedical Sciences Faculty Research and Publications

Thrombin binds to fibrin at two classes of non-substrate sites, one of high affinity and the other of low affinity. We investigated the location of these thrombin binding sites by assessing the binding of thrombin to fibrin lacking or containing γ′ chains, which are fibrinogen γ chain variants that contain a highly anionic carboxyl-terminal sequence. We found the high affinity thrombin binding site to be located exclusively in D domains on γ′ chains (K_a, 4.9 × 10⁶⁻¹; n, 1.05 per γ′ chain), whereas the low affinity thrombin binding site was in the fibrin E …

The Protective Role Of Manganese Superoxide Dismutase Against Adriamycin-Induced Acute Cardiac Toxicity In Transgenic Mice, Hsiu-Chuan Yen, Terry D. Oberley, Satit Vichitbandha, Ye-Shih Ho, Daret K. St. Clair

Toxicology and Cancer Biology Faculty Publications

Adriamycin (ADR) is a potent anticancer drug known to cause severe cardiac toxicity. Although ADR generates free radicals, the role of free radicals in the development of cardiac toxicity and the intracellular target for ADR-induced cardiac toxicity are still not well understood. We produced three transgenic mice lines expressing increased levels of human manganese superoxide dismutase (MnSOD), a mitochondrial enzyme, as an animal model to investigate the role of ADR-mediated free radical generation in mitochondria. The human MnSOD was expressed, functionally active, and properly transported into mitochondria in the heart of transgenic mice. The levels of copper-zinc SOD, catalase, and …

Coherency Among Substance Abuse Models, Stephen Kauffman, John Poulin

The Journal of Sociology & Social Welfare

Social policy decisions are often made based upon socially constructed models of human behavior. As such, understanding the social constructions in a given policy area is of utmost importance. This study examines three competing models within the substance abuse area: the moral model, the disease model, and the biopsychosocial model. Utilizing survey data from a random sample telephone survey of 1,019 residents of Delaware County, Pennsylvania, the study examines a) the degree to which individual models are internally consistent between beliefs about causes and beliefs about solutions, b) whether the assumptions in competing models are in fact different; and c) …

Books Received And Book Notices, The Jonathan Nāpela Center For Hawaiian And Pacific Islands Studies

Pacific Studies

Book Listing for the Vol 19, No 3 Edition of the Pacific Studies Journal

Prevalence Of Antibodies To Feline Parvovirus, Calicivirus, Herpesvirus, Coronavirus, And Immunodeficiency Virus And Of Feline Leukemia Virus Antigen And The Interrelationship Of These Viral Infections In Free-Ranging Lions In East Africa, Regina Hofmann-Lehmann, Daniela Fehr, Markus Grob, Muhamed Elgizoli, Craig Packer, Janice S. Martenson, Stephen J. O'Brien, Hans Lutz

Biology Faculty Articles

While viral infections and their impact are well studied in domestic cats, only limited information is available on their occurrence in free-ranging lions. The goals of the present study were (i) to investigate the prevalence of antibodies to feline calicivirus (FCV), herpesvirus (FHV), coronavirus (FCoV), parvovirus (FPV), and immunodeficiency virus (FIV) and of feline leukemia virus (FeLV) antigen in 311 serum samples collected between 1984 and 1991 from lions inhabiting Tanzania’s national parks and (ii) to evaluate the possible biological importance and the interrelationship of these viral infections. Antibodies to FCV, never reported previously in free-ranging lions, were detected in …

Review Of: Science Advice To The President (William T. Golden, Ed. Aaas Press 2d Ed. 1993)., Timothy Van Dyke

RISK: Health, Safety & Environment (1990-2002)

Review of: Science Advice to the President (William T. Golden, ed. AAAS Press 2d Ed. 1993). Acknowledgments, index of names, introductions, notes, tables. ISBN 0-87168-509-4 [340 pp. $29.95 paper. American Association for the Advancement of Science, 1333 H St. NW, Washington DC 20701.]

Hereditary Ovarian Cancer Syndromes In Three Pakistani Families, A B. Aziz, M Sabih, I A. Malik

Department of Obstetrics & Gynaecology

No abstract provided.