Digital Commons Network^™

The Role Of Zinc In Health And Disease: Relevance To Child Health In Developing Countries, Z A. Bhutta

Department of Paediatrics and Child Health

No abstract provided.

Adaptation Of The Doubly Labeled Water Method For Subjects Consuming Isotopically Enriched Water, Randall J. Gretebeck, Dale A. Schoeller, Rick A. Socki, Janis Davis-Street, Everett K. Gibson, Leslie O. Schulz, Helen W. Lane

College of Nursing Faculty Research and Publications

The use of doubly labeled water (DLW) to measure energy expenditure is subject to error if the background abundance of the oxygen and hydrogen isotope tracers changes during the test period. This study evaluated the accuracy and precision of different methods by which such background isotope changes can be corrected, including a modified method that allows prediction of the baseline that would be achieved if subjects were to consume water from a given source indefinitely. Subjects in this study were eight women (4 test subjects and 4 control subjects) who consumed for 28 days water enriched to resemble drinking water …

Functional Analysis Of Surfactant Protein B (Sp-B) Promoter. Sp1, Sp3, Ttf-1, And Hnf-3Α Transcription Factors Are Necessary For Lung Cell-Specific Activation Of Sp-B Gene Transcription, Ramgopol K. Margana, Vijayakumar Boggaram

School of Medical and Biological Sciences Faculty Publications and Presentations

Surfactant protein B (SP-B) is essential for maintenance of biophysical properties and physiological function of pulmonary surfactant. SP-B mRNA expression is restricted to alveolar type II epithelial cells and bronchiolar epithelial cells (Clara cells) of adult lung. We previously (Margana, R. K., and Boggaram, V. (1996) Am. J. Physiol. 270, L601-L612) found that a minimal promoter region (-236 to +39) of rabbit SP-B gene is sufficient for high level expression of chloramphenicol acetyltransferase reporter gene in NCI-H441 cells, a cell line with characteristics of Clara cells. In the present study we used mutational analysis, electrophoretic mobility shift assays, and DNase …

Safety Guidelines For Occupational Hazards To The Reproductive System, Laverne Raquel Ogieste

Theses

Most workers are unaware of the hazards to the reproductive system that surround them in the workplace, and therefore, few if any precautions are taken to avoid unnecessary exposures. In this research, safety guidelines were developed in order to eliminate such dangers from occurring or reoccurring.

These guidelines were developed by reviewing case studies of occupational hazards to the reproductive system, including federal laws and regulations related to safety within the workplace. The following forms were also developed in order to formulate suitable safety guidelines for occupational hazards to the reproductive system. They are: an occupational reproductive survey, a reproductive …

A Heterodimer Of Thioredoxin And Ib2 Cooperates With Sec18p (Nsf) To Promote Yeast Vacuole Inheritance, Zuoyu Xu, Andreas Mayer, Eric Muller, William Wickner

Dartmouth Scholarship

Early in S phase, the vacuole (lysosome) of Saccharomyces cerevisiae projects a stream of vesicles and membranous tubules into the bud where they fuse and establish the daughter vacuole. This inheritance reaction can be studied in vitro with isolated vacuoles. Rapid and efficient homotypic fusion between saltwashed vacuoles requires the addition of only two purified soluble proteins, Sec18p (NSF) and LMA1, a novel heterodimer with a thioredoxin subunit. We now report the identity of the second subunit of LMA1 as IB2, a previously identified cytosolic inhibitor of vacuolar proteinase B. Both subunits are needed for efficient vacuole inheritance in vivo …

Diffusion Behavior Of Lipid Vesicles In Entangled Polymer Solutions, X. Cao, R. Bansil, D. Gantz, E.W. Moore, N. Niu, Nezam H. Afdhal

Internal Medicine Publications

ABSTRACT

Dynamic light scattering was used to follow the tracer diffusion of phospholipid/cholesterol vesicles in aqueous polyacrylamide solutions and compared with the diffusive behavior of polystyrene (PS) latex spheres of comparable diameters. Over the range of the matrix concentration examined (Cp = 0.1-10 mg/ml), the diffusivities of the PS spheres and the large multilamellar vesicles exhibited the Stokes-Einstein (SE) relation, while the diffusivity of the unilamellar vesicles did not follow the increase of the solution's viscosity caused by the presence of the matrix molecules. The difference between the diffusion behaviors of unilamellar vesicles and hard PS spheres of similar size …

An Immunomodulating Mycotoxin Interferes With The Development Of Autoimmune Diabetes In Diabetes-Prone Bb/Wor Rats, Honggang Liu

Theses, Dissertations and Capstones

Various fungal products have immunomodulating activity and some have been studied regarding prevention of transplantation rejection. Prior to this investigation, the mycotoxin, gliotoxin (GT), has never been investigated as an immunotherapeutic drug for autoimmune disease. GT is a fungal secondary metabolite and a member of the epipolythiodioxopiperazine (ETP) family which has been shown to inhibit phagocytosis, induction of cytolytic T cells and the proliferation of T cells following mitogen stimulation. GT also induces in vitro apoptosis in certain immune cell types. More importantly, GT exhibits selective activity towards cells of hemopoietic origin.

Autoimmune diseases are disorders caused by immune responses …

Relationship Of Resting And Submaximal Cardiovascular Measures To Vo[2]Max In Untrained Children, Thomas A. Cappaert

Theses, Dissertations and Capstones

Participation by children in organized sport continues to increase. A 1994 survey of 10,000 households by the National Sporting Goods Association (1994) found that approximately 40,000 children between the ages of 7-17 years participate in an organized sport or recreational activity annually. In the realm of organized sports, especially endurance activities, there continues to be interest in how cardiovascular fitness is attained and how it can be maximized. Measurement of cardiovascular fitness is an important piece to that puzzle.

The most common and most descriptive measure for children and adults, is the maximal oxygen uptake or max (Astrand & Rodahl, …

Articulations 1997, Som School Of Osteopathic Medicine, Umdnj University Of Medicine And Dentistry Of Nj

Yearbooks

University of Medicine and Dentistry of New Jersey (UMDNJ) School of Osteopathic Medicine yearbook for the class of 1997. 114 pages.

Contents: Poem: "Janet and Tony" p. 1, UMDNJ-SOM Campus p. 2, University Affiliated Medical Centers p. 3, Dean's Message p. 4, Administration p. 5, Faculty p. 6, Candids p. 7, Class of 1997 p. 34, Convocation and Graduation p. 96, Class of 1997 Directory p. 102, Yearbook Staff p. 102, Osteopathic Oath p. 104.

Health Professions Division Catalog Academic Year 1997-1998, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Aspartate 19 And Glutamate 121 Are Critical For Transport Function Of The Myo-Inositol/H+ Symporter From Leishmania Donovani, Andreas Seyfang, Michael Kavanaugh, Scott M. Landfear

Biomedical and Pharmaceutical Sciences Faculty Publications

The protozoan flagellate Leishmania donovani has an active myo-inositol/proton symporter (MIT), which is driven by a proton gradient across the parasite membrane. We have used site-directed mutagenesis in combination with functional expression of transporter mutants in Xenopusoocytes and overexpression in Leishmania transfectants to investigate the significance of acidic transmembrane residues for proton relay and inositol transport. MIT has only three charged amino acids within predicted transmembrane domains. Two of these residues, Asp¹⁹ (TM1) and Glu¹²¹ (TM4), appeared to be critical for transport function of MIT, with a reduction of inositol transport to about 2% of wild-type …

Tyrosine 140 Of The Γ-Aminobutyric Acid Transporter Gat-1 Plays A Critical Role In Neurotransmitter Recognition, Yona Bismuth, Michael Kavanaugh, Baruch I. Kanner

Biomedical and Pharmaceutical Sciences Faculty Publications

The γ-aminobutyric acid (GABA) transporter GAT-1 is located in nerve terminals and catalyzes the electrogenic reuptake of the neurotransmitter with two sodium ions and one chloride. We now identify a single tyrosine residue that is critical for GABA recognition and transport. It is completely conserved throughout the superfamily, and even substitution to the other aromatic amino acids, phenylalanine (Y140F) and tryptophan (Y140W), results in completely inactive transporters. Electrophysiological characterization reveals that both mutant transporters exhibit the sodium-dependent transient currents associated with sodium binding as well as the chloride-dependent lithium leak currents characteristic of GAT-1. On the other hand, in both …

Mutation Of An Amino Acid Residue Influencing Potassium Coupling In The Glutamate Transporter Glt-1 Induces Obligate Exchange, Michael Kavanaugh, Annie Bendahan, Noa Zerangue, Yumin Zhang, Baruch I. Kanner

Biomedical and Pharmaceutical Sciences Faculty Publications

Glutamate transporters maintain low synaptic concentrations of neurotransmitter by coupling uptake to flux of other ions. After cotransport of glutamic acid with Na⁺, the cycle is completed by countertransport of K⁺. We have identified an amino acid residue (glutamate 404) influencing ion coupling in a domain of the transporter implicated previously in kainate binding. Mutation of this residue to aspartate (E404D) prevents both forward and reverse transport induced by K⁺. Sodium-dependent transmitter exchange and a transporter-mediated chloride conductance are unaffected by the mutation, indicating that this residue selectively influences potassium flux coupling. The results …

Ada News Daily - 1997 Day 3, American Dental Association, Publishing Division

ADA News

The ADA News Daily (also called the ADA News Convention Daily) is a special edition of the ADA News published each day during American Dental Association Annual Sessions.

Discrepancies In Social Workers' Self-Perception In Theoretical And Treatment Approaches To Depressed Late Middle-Age Women, Enid Aida Velasco

Theses Digitization Project

No abstract provided.

Interprofessional Expectations Of The Medical Social Worker In Home Health Care, Wendy Marie Schill

Theses Digitization Project

No abstract provided.

Sexuality And Related Social Skills Training: Meeting The Challenge For Adults With Developmental Disabilities, Caroline Mary Adkison

Theses Digitization Project

Historically, people with developmental disabilities were denied the right to live in and integrate with the society of individuals without disabilities. Landmark legislation and a societal shift over the past two decades, however, have made it possible for people with developmental disabilities to live and work in the communities in which they live.

Outlook Magazine, Spring 1997

Outlook Magazine

No abstract provided.

Outlook Magazine, Winter 1997

Outlook Magazine

No abstract provided.

Joint Mobilization For The Lower Extremity, Michelle C. Robert

Physical Therapy Scholarly Projects

In the field of physical therapy there are a number of therapeutic techniques used for evaluation and treatment of dysfunction. There is one technique that is seen especially jn the orthopedic setting and has been around since ancient Egyptian times. 1,2 This technique is joint mobilization and even though there are limited studies on its usefulness, it can not be ignored as a treatment technique. Due to the complexity of the techniques, students often need additional resource materials to assist in the learning process.

Therefore, the purpose of this paper is to introduce theoretical background, terminology, and an explanation of …

Harry F. Harlow And Animal Research: Reflection On The Ethical Paradox, John P. Gluck

Experimentation Collection

With respect to the ethical debate about the treatment of animals in biomedical and behavioral research, Harry F. Harlow represents a paradox. On the one hand, his work on monkey cognition and social development fostered a view of the animals as having rich subjective lives filled with intention and emotion. On the other, he has been criticized for the conduct of research that seemed to ignore the ethical implications of his own discoveries. The basis of this contradiction is discussed and propositions for current research practice are presented.

The Effects Of Training On Cervical Range Of Motion Between Unilateral Breathers And Bilateral Breathers In Collegiate Swimmers During Freestyle Swimming, Anjanette Wong

Physical Therapy Scholarly Projects

The purpose of this study was to establish data on active cervical range of motion for collegiate freestyle swimmers, to determine if training has an effect on cervical range of motion, and to investigate if breathing style influences cervical rotation to the right and left after training. The sample consisted of 29 varsity swim team members from the University of North Dakota (12 females and 17 males) who had participated in experiment IRB-9504-257. This past study was performed at the start of the competitive swim season, and its measurements used as pre-season data. The same CROM device was used to …

Orphanages In America: Are They Needed?, Cara Lynn Hans, Lawrence Payne

Theses Digitization Project

The purpose of this constructivist research study was to examine the idea of returning to the orphanage system, as a placement option for children who have been removed from their homes. The authors felt that this was especially important since lawmakers have been discussing this option as an answer to the question of welfare reform, and further felt that decisions such as these should not be made without the input of professionals in the social work field.

Many Voices: Medical Anthropologists Explore The Meaning Of Health, Illness, And Cure, Michael Hass

Education Faculty Articles and Research

Lindenbaum, Shirley and Margaret Lock, eds. Knowledge, Power and Practice: The Anthropology of Medicine in Everyday Life. Berkeley: University of California Press, 1993. xvii + 242 pp. including notes, references, and indices. $50.00 cloth, $15.00 paper.

Etkin, Nina L. and Michael L. Tan, eds. Medicines: Meanings and Contexts. Quezon city, Philippines and Amsterdam: Health Action Information Network and the University of Amsterdam, 1994. v + 305 pp. $15.00 paper.

Good, Byron J. Medicine, Rationality, and Experience: an Anthropological Perspective. Cambridge: Cambridge University Press, 1994. $54.95 Cloth, $17.95 paper.

Virginia Dental Journal (Vol. 74, No. 2, 1997)

Virginia Dental Journal

No abstract provided.

Hydroxylation Of Saccharomyces Cerevisiae Ceramides Requires Sur2p And Scs7p, Dale Haak, Ken Gable, Troy Beeler, Teresa Dunn

Uniformed Services University of the Health Sciences

The Saccharomyces cerevisiae SCS7 and SUR2 genes are members of a gene family that encodes enzymes that desaturate or hydroxylate lipids. Sur2p is required for the hydroxylation of C-4 of the sphingoid moiety of ceramide, and Scs7p is required for the hydroxylation of the very long chain fatty acid. Neither SCS7 nor SUR2 are essential for growth, and lack of the Scs7p- or Sur2p- dependent hydroxylation does not prevent the synthesis of mannosyldiinositolphosphorylceramide, the mature sphingolipid found in yeast. Deletion of either gene suppresses the Ca²⁺-sensitive phenotype of csg2Δ mutants, which arises from overaccumulation of inositolphosphorylceramide due to …

Outlook Magazine, Summer 1997

Outlook Magazine

No abstract provided.

Childhood Physical Or Sexual Abuse As A Possible Indicator Of Subsequent Adult Anxiety Disorders, Lynn Merry Cornwell

Graduate Research Papers

In recent years, there has been a growing acceptance that childhood physical and sexual abuse lead to higher rates of psychiatric morbidity in adulthood. Childhood abuse experiences have been reported to be highly prevalent among patients with anxiety disorders. Similarly, childhood incest victims have been found to suffer from a significantly higher rate of anxiety disorders in adulthood especially agoraphobia, than a non-victimized, matched comparison group. Epidemiology studies also support a relationship between childhood abuse and the subsequent development of anxiety disorders. Two separate community surveys found that childhood sexual victimization predicted the later onset of agoraphobia, obsessive-compulsive disorder, and …

Association Between Plasma Homocysteine, Vitamin Status, And Extracranial Carotid-Artery Stenosis In The Framingham Study Population, Jacob Selhub, Paul F. Jacques, Andrew G. Bostrom, Ralph B. D'Agostino, Peter W. F. Wilson, Albert J. Belanger, Daniel H. O'Leary, Philip A. Wolf, David Rush, Ernst J. Schaefer, Irwin H. Rosenberg

United States Public Health Resources

Recent epidemiologic studies suggest that elevated homocysteine concentrations in plasma represent a risk factor for vascular disease and stroke. In the present study, we analyzed plasma samples from the 20th biannual examination of the Framingham Heart Study cohort to determine distribution of plasma homocysteine concentrations, with emphasis on relationships to vitamins that are involved in homocysteine metabolism and prevalence of carotid artery stenosis. Results showed that homocysteine was positively correlated with age. After controlling for age and sex, homocysteine exhibited strong inverse correlation with plasma folate, and weaker correlations with plasma vitamin B₁₂ and pyridoxal- 5' -phosphate. Homocysteine was …

Cystathionine Β-Synthase Deficiency: Metabolic Aspects, S. Harvey Mudd

United States Public Health Resources

Cystathionine β-synthase (CBS) deficiency was first demonstrated in 1964 in an eight-year-old mentally retarded girl with bilaterally dislocated optic lenses who excreted abnormally elevated amounts of homocystine in her urine. Patients with similar metabolic abnormalities and clinical findings had first been discovered 2 years earlier by Carson and her colleagues during a survey of mentally backward children in Northern Ireland. CBS deficiency has proven to be the most frequently encountered of the human genetic diseases causing homocystinuria and severe hyperhomocyst(e)inemia. Worldwide, it is detected with a frequency of about 1: 344,000 by screening programs of the newborn, but this is …