Digital Commons Network^™

Frequency Of Fab Subtypes In Acute Myeloid Leukemia Patients At Aga Khan University Hospital Karachi, Mahadev Sajanmal Harani, Salman Adil, Mohammad Usman Shaikh, G N Kakepoto, Mohammad Khurshid

Department of Pathology and Laboratory Medicine

BACKGROUND: Acute myeloid leukemia (AML) is a heterogeneous disease. Therefore, various parameters are needed to classify this disease into subtypes, so that specific treatment approaches can be utilized effectively. The commonly used method for diagnosis and classification is based on FAB criteria using morphology and cytochemical stains. For some of the categories, immunophenotyping is necessary. The aim of present study is to determine the frequency of various sub types in acute myeloid leukemia using FAB criteria in our population. This will aid in the correct diagnosis of acute leukemia and hence proper management of the patients.
MATERIALS AND METHODS …

Vi Antigen Expression In Salmonella Enterica Serovar Typhi Clinical Isolates From Pakistan, John Wain, Deborah House, Afia Zafar, Stephen Baker, Satheesh Nair, Claire Kidgell, Zulfiqar Bhutta, Gordon Dougan, Rumina Hasan

Department of Pathology and Laboratory Medicine

The accurate identification of Salmonella enterica subsp. enterica serovar Typhi variants that fail to express the capsular polysaccharide, Vi, is an important and much discussed issue for medical microbiology. We have tested a multiplex PCR method which shows the presence or absence of the genetic locus required for Vi expression. Of 2,222 Salmonella serovar Typhi clinical isolates collected from patients' blood over a 4-year period in a region of Pakistan where typhoid is endemic, 12 tested negative for Vi expression by serological agglutination. However, only 1 of these 12 was Vi negative by the multiplex PCR method. This result was …

Periplasm Organization In Treponema Denticola As Studied By Cryo-Electron Tomography, Jacques Izard, C.-E. Hsieh, C. A. Mannella, Ronald J. Limberger, M. Marko

Department of Food Science and Technology: Faculty Publications

As a spirochete, the genus Treponema is one of the few major bacterial groups whose natural phylogenic relationships are evident at the level of gross phenotypic characteristics such as their morphology. Treponema spp. are highly invasive due to their unique motility in dense media, and their ability to penetrate cell layers. This feature is associated with the helical cell body and the presence of flagellar filaments in the periplasm. Treponema denticola is an oral pathogen involved in endodontic infections and periodontal diseases. The presence and quantity of T. denticola in the subgingival biofilm is correlated with the severity of periodontal …

African American Breast Cancer Health Disparities, Theresa Lynn Gaul

Honors Program Theses

Health disparities are "the differences in the incidence, prevalence, mortality, and burden of cancer and related adverse health conditions that exist among specific population groups in the United States" (National Cancer Institute [NCI], 2002). Racial and ethnic minorities experience serious disparities in health access and outcomes. Disparities in the burden of death and illness experienced by African Americans in particular, as compared with our nation's population as a whole, are particularly striking. There are a variety of factors contributing to these inequalities. The purpose of this report is to examine these factors and the consequential effects on the African American's …

Effects Of Unilateral Extraction Treatment On Arch Symmetry And Occlusion, Theodore William Struhs

Theses and Dissertations

Occlusal asymmetries are common in orthodontic patients. A treatment option for correcting moderate asymmetries is asymmetric extractions. This study evaluated post-treatment dental arch symmetry in patients treated with unilateral premolar extractions. Post-treatment casts of 60 patients were divided into four treatment groups based on the history of occlusal asymmetry and the treatment plan. DesignCAD3000 software (Upperspace Corporation, Pryor, OK) was used to evaluate asymmetrically treated arches for symmetry. The four treatment groups were compared to identify differences in arch asymmetry based on treatment. The lateral incisor and canine were found to be more palatal on the extraction side in patients …

Evidence For Absence Of Latchbridge Formation In Phasic Saphenous Artery, Shaojie Han

Theses and Dissertations

Tonic arterial smooth muscle can produce strong contractions indefinitely by formation of slowly cycling crossbridges (latchbridges) that maintain force at a high energy economy. To fully understand the uniqueness of mechanisms regulating tonic arterial contraction, comparisons have been made to phasic visceral smooth muscles that do not sustain high forces. This study explored mechanisms of force maintenance in a phasic artery by comparing KCl-induced contractions in the tonic, femoral artery (FA) and its primary branch, the phasic saphenous artery (SA). KCl rapidly (5 N/m2) and [ca2+]i (250 nM) in FA and SA. By 10 min, [ca2+]i declined to 175 nM …

Faculty Publications 2004, Lsu Health Sciences Center New Orleans

Historical Faculty Publications

This Faculty bibliography contains 1027 publications.

Ccl20/Macrophage Inflammatory Protein 3Α And Tumor Necrosis Factor Alpha Production By Primary Uterine Epithelial Cells In Response To Treatment With Lipopolysaccharide Or Pam3cys, M. A. Crane-Godreau, C. R. Wira

Dartmouth Scholarship

Having previously shown that CCL20/macrophage inflammatory protein 3 and tumor necrosis factor alpha (TNF-alpha) are released by polarized primary rat uterine epithelial cells (UEC) in response to Escherichia coli but not to Lactobacillus rhamnosus , we sought to determine if epithelial cells are responsive to pathogen-associated molecular patterns (PAMP), including lipopolysaccharide (LPS), lipoteichoic acid (LTA), and Pam 3 Cys, a bacterial lipoprotein analog. Epithelial cells were grown to confluence on Nunc cell culture inserts prior to apical treatment with PAMPs. In response to LPS, LTA, and Pam 3 Cys (EMC Microcollection GmbH, Tu ̈- bingen, Germany), CCL20 levels increased (4- …

Identification Of Fatty Acid Oxidation Disorder Patients With Lowered Acyl-Coa Thioesterase Activity In Human Skin Fibroblasts, Mary Hunt, Jos Ruiter, Petra Mooyer, Carlo W T Van Roermond, Rob Ofman, Lodewig Ijlst, Ronald J A Wanders

Articles

Background: Acyl-CoA thioesterases are enzymes that hydrolyze acyl-CoAs to the free fatty acid and coenzyme A (CoASH). These enzymes have been identified in several cellular compartments and are thought to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. However, to date no patients deficient in acyl-CoA thioesterases have been identified. Design: Acyl-CoA thioesterase activity was measured in human skin fibroblasts. Western blot analysis was used to determine Type-II acyl-CoA thioesterase protein levels in patients. Results: Activity was found in human fibroblasts with all saturated acyl-CoAs from C4:0- to C18:0-CoA, with highest activity detected with lauroyl-CoA and myristoyl-CoA (C12:0 …

Gene Therapy And Targeted Toxins For Glioma, James Curtin, Gwendalyn King, Marianela Candolfi, Kurt Kroeger, Pedro Lowenstein, Maria Castro

Articles

The most common primary brain tumor in adults is glioblastoma. These tumors are highly invasive and aggressive with a mean survival time of nine to twelve months from diagnosis to death. Current treatment modalities are unable to significantly prolong survival in patients diagnosed with glioblastoma. As such, glioma is an attractive target for developing novel therapeutic approaches utilizing gene therapy. This review will examine the available preclinical models for glioma including xenographs, syngeneic and genetic models. Several promising therapeutic targets are currently being pursued in pre-clinical investigations. These targets will be reviewed by mechanism of action, i.e., conditional cytotoxic, targeted …

Combining Cytotoxic And Immune-Mediated Gene Therapy To Treat Brain Tumors, James Curtin, Gwendalyn King, Marianela Candolfi, Remy Greeno, Kurt Kroeger, Pedro Lowenstein, Maria Castro

Articles

Glioblastoma (GBM) is a type of intracranial brain tumor, for which there is no cure. In spite of advances in surgery, chemotherapy and radiotherapy, patients die within a year of diagnosis. Therefore, there is a critical need to develop novel therapeutic approaches for this disease. Gene therapy, which is the use of genes or other nucleic acids as drugs, is a powerful new treatment strategy which can be developed to treat GBM. Several treatment modalities are amenable for gene therapy implementation, e.g. conditional cytotoxic approaches, targeted delivery of toxins into the tumor mass, immune stimulatory strategies, and these will all …

Relationships Among Pre-Admission Characteristics In Associate Degree Nursing Programs As Predictors Of Nclex-Rn Success., Gloria J. Wacks

All ETDs from UAB

No abstract provided.

Maternal Oral Health And Preterm Low Birth Weight In Pakistan., Amyn Lakhani

All ETDs from UAB

No abstract provided.

Hiv Infection Among African American Women: A Descriptive Study., Rebecca Bothwell-Ephraim

All ETDs from UAB

No abstract provided.

The Relative Risk Of Mortality Associated With The 10th Percentile Of Birth Weight For Gestational Age Among Singleton Infants Born To United States Resident Mothers, 1995-1999., Sheree L. Boulet

All ETDs from UAB

No abstract provided.

An Evaluation Of The Human Pathogen Transmission Potential Of Selected Wastewater Treatment Systems, With The Development Of A Rating System For Public Use In Selecting A System For Home Installation., Joseph Stanley Jablecki

All ETDs from UAB

No abstract provided.

Perceived Loneliness, Helplessness, And Boredom Of Elderly Residents In Eden Nursing Homes., Robin Brush Parnell

All ETDs from UAB

No abstract provided.

Environmental Health Practitioners In Alabama: An Assessment Of The Practice Of The Ten Essential Services And Abilities In The Fourteen Core Competencies., Christie Mccullum-Hill

All ETDs from UAB

No abstract provided.

Predictors Of Family-Related Indirect Costs For Asthma In Low -Income African American Children: Morbidity, Adherence, And Psychosocial Risk Factors., Chanda Nicole Mobley

All ETDs from UAB

No abstract provided.

Biomarkers For Placental Abnormality, Cathal Mccarthy

Doctoral

Obstetrical complications including recurrent miscarriage, pre-eclampsia and intrauterine growth restriction (IUGR) affect 1%-5% of pregnant women (Younis and Samueloff 2003). Dysfunctional trophoblasts, impaired development of spiral arteries, imbalance in systems controlling the dilation and contraction of spiral arteries, placental fibrin clots and intervillous thrombosis are all possible factors that can result in an insufficient placental circulation. The combination of the hypercoagulable state of pregnancy and presence of genetic thrombophilic markets has the potential to induce placental thrombosis and cause placental insufficiency with subsequent obstetrical complications. The initial part of the research work involved examining the relationship between four common genetic …

Spiritual Well-Being And Quality Of Life As Correlates Of Job Stress Among Academic Chairpersons In Selected Seventh-Day Adventist Tertiary Institutions, Russell Mark Aldridge

Dissertations

Problem . Stress, like pain, begins at birth and remains common to the human condition throughout life, and it is a factor in the experience of every human being who ever lived. It is not merely universal but it is also endemic and omnipresent. Chairpersons, due to the bi-directional demands of administration and students are in a stressful environment. This study was undertaken to identify whether quality of life and spiritual well-being play an important role in occupational stress levels in chairpersons of Seventh-day Adventist Tertiary Institutions.

Method. Three questionnaires were used to get responses from 137 chairpersons in …

Applying The Information-Motivation-Behavioral Skills Model Of Hiv- Risk To Youth In Psychiatric Care, Geri R. Donenberg, Rebecca Moss Schwartz, Erin Emerson, Helen W. Wilson, Fred B. Bryant, Gloria Coleman

Psychology: Faculty Publications and Other Works

This study examined the utility of cognitive and behavioral constructs (AIDS in-formation, motivation, and behavioral skills) in explaining sexual risk taking among 172 12–20–year-old ethnically diverse urban youths in outpatient psy-chiatric care. Structural equation modeling revealed only moderate support for the model, explaining low to moderate levels of variance in global sexual risk taking. The amount of explained variance improved when age was included as a predictor in the model. Findings shed light on the contribution of AIDS informa-tion, motivation, and behavioral skills to risky sexual behavior among teens re-ceiving outpatient psychiatric care. Results suggest that cognitive and behavioral factors …

Caduceus 2005, Stritch School Of Medicine

Stritch School of Medicine Yearbooks

No abstract provided.

Conjugated Linoleic Acid: Chemical Structure, Sources And Biological Properties, Rahi̇m Aydin

Turkish Journal of Veterinary & Animal Sciences

Conjugated linoleic acid (CLA) is a group of geometrical and positional isomers of linoleic acid (C18:2, cis-9, cis-12). In contrast to linoleic acid, double bonds in CLA are usually located at positions 9 and 11 or 10 and 12 and each double bond can be either in the cis or trans configuration. Meat and dairy products from ruminant animals (such as milk, butter, yogurt and cheese) are the principal natural sources of CLA in the human diet. Egg and meat products from poultry contain less CLA than meat from ruminant animals (0.6 and 0.9 mg/g fat vs. 2.9 to 5.6 …

Some Biological Characteristics Of The Tub Gurnard, Chelidonichthys Lucernus (Linnaeus, 1758) In The Sea Of Marmara, Lütfi̇ye Eryilmaz, Nuretti̇n Meri̇ç

Turkish Journal of Veterinary & Animal Sciences

The biology of the tub gurnard, Chelidonichthys lucernus (Linnaeus, 1758), has been studied on data collected between November 1996 and November 1997 from the Sea of Marmara. Totally, 224 tub gurnards were sampled. The age, growth, length-weight relationship, condition factor, male to female ratio, first sexual maturity age, length and reproduction period were examined. The age composition of samples ranged between 1 and 6 years. Total length ranged between 12.3 and 41.5 cm, while weight varied from 15 to 617 g. The total length-weight relationship was estimated as W=0.0092L^{3.019}. The parameters of the von Bertalanffy growth equation were: L_{\infity} = …

Some Biological Aspects Of Parapenaeus Longirostris (Lucas, 1846) (Crustacea, Decapoda) Inhabiting The Sea Of Marmara, Yusuf Kenan Bayhan, Tarik Ünlüer, Mehmet Akkaya

Turkish Journal of Veterinary & Animal Sciences

In this study, carried out between November 2000 and October 2001, the annual spawning period, first maturity length, length frequency distribution and length/weight relationship of Parapenaeus longirostris that inhabit most commonly the Sea of Marmara were investigated. Analysis of the data obtained from this study revealed that although the mature individuals with fully developed eggs were found almost every month throughout the year, the highest gonadosomatic index values were obtained in September, October, December, April and May. The total length at which 50% of the population reaches maturity is calculated to be 9.7 cm. Among the individuals caught, females at …

Vaccine-Associated Feline Sarcoma (Vafs) With Multiple Recurrences In A Turkish Van Cat, Yilmaz Aydin, Babür Bi̇li̇r

Turkish Journal of Veterinary & Animal Sciences

Vaccine-associated feline sarcoma (VAFS) with multiple recurrences was diagnosed in the specimens at the injection site of a Turkish Van cat that had been vaccinated four months previously. The original tumor consisted of two compartments each 2.5 cm and 3.5 cm in diameter. It recurred five times following surgery and local recurrences necessitated five more radical resections within two years. Euthanasia was performed when pleural effusion developed, but evidence of metastatic disease was not observed. This article reports the first case of a vaccine-associated feline sarcoma in a Turkish Van cat clinically diagnosed as prominent evidence of postvaccinal sarcoma from …

Men, Muscles, And Body Image: Comparisons Of Competitive Bodybuilders, Weight Trainers, And Athletically Active Controls, T. C. Pickett, R. J. Lewis, T. F. Cash, H. G. Pope

Psychology Faculty Publications

Objectives: To investigate body image and psychosocial adjustment among competitive bodybuilders, non-competitive weight trainers, and athletically active men.

Methods: Participants were 40 men in each of the three groups who were assessed on body composition and multiple facets of body image evaluation, investment and anxiety, eating attitudes, and social self esteem.

Results: Relative to the other two groups, competitive bodybuilders had greater body mass due to fat-free body mass. Although groups did not differ in their situational body image discomfort, competitive bodybuilders and weight trainers had a more positive global appearance evaluation and were more psychologically invested in their physical …

Mechanism Of Cancer Selective Apoptosis By Par-4, Sushma Gurumurthy

University of Kentucky Doctoral Dissertations

Despite distinct dissimilarities, diverse cancers express several common pro-tumorigenic traits. We present here evidence that the pro-apoptotic protein Par-4 utilizes one such common tumorigenic trait to become selectively activated and induce apoptosis in cancer cells. Elevated PKA activity noted in cancer cells activated the apoptotic function of ectopic Par-4 or its SAC domain, which induces apoptosis selectively in cancer cells and not in normal or immortalized cells. PKA preferentially phosphorylated Par-4 at the T155 residue within the SAC domain in cancer cells. Moreover, pharmacological-, peptide- or siRNA-mediated inhibition of PKA activity in cancer cells resulted in abrogation of both T155 …

New Low- And High-Tech Calendar Methods Of Family Planning, Richard J. Fehring

College of Nursing Faculty Research and Publications

Calendar-based methods are not usually considered effective or useful methods of family planning among health professionals. However, new “high-” and “low”-tech calendar methods have been developed, which are easy to teach, to use, and may be useful in helping couples avoid pregnancy. The low-tech models are based on a fixed-day calendar system. The high-tech models are based on monitoring urinary metabolites of female reproductive hormones. Both systems have high levels of satisfaction. This article describes these new models of family planning and the research on their effectiveness. The author proposes a new algorithm for determining the fertile phase of the …