Digital Commons Network^™

Anti-Cancer Activity Of Marine-Derived Fucosylated Chondroitin Sulfates In Ovarian Cancer Cell Spheroid Formation And Notch Signaling Inhibition, Daniella Beiner

Honors Theses

Ovarian cancer is the deadliest gynecological malignancy, with high recurrence rates driven by chemotherapy-resistant cancer stem cells (CSCs). Current therapeutics targeting Notch signaling to inhibit CSC formation have yet to demonstrate clinical benefit and pose risk of gastrointestinal toxicities. Here, we report that treatment with fucosylated chondroitin sulfates (FucCS) inhibited Notch signaling activation and spheroid formation in OVCAR3 ovarian cancer cells. Sulfation and fucosylation were shown to be key structural requirements of this anti-cancer activity. Moreover, this inhibition was synergistic with suppression of Notch glycosylation by Radical Fringe knockout. Preliminary experiments to conjugate FucCS to a maleimide linker in preparation …

Coordinating Connections: A Mixed-Methods Exploration Of Relational Coordination And Interprofessional Team Development With Health Professions Students And Survivors Of Stroke, Teresa Marie Cochran

Theses & Dissertations

The need for effective healthcare teams is widely recognized, yet strategies for team education and evaluation remain areas of ongoing investigation. This study presents a longitudinal, interprofessional tele-team learning initiative designed to enhance health professions students’ collaborative skills through Salas’ “Big Five” of Teamwork and Gittell’s Relational Coordination Theory. Additionally, the project aimed to mitigate social isolation among stroke survivors by forming nine interprofessional tele-teams composed of students from medical nutrition therapy, nursing, occupational therapy, physical therapy, and speech-language pathology. Over six virtual meetings, these teams engaged with stroke survivors, assisting them in progressing toward self-selected goals.

Using an explanatory …

Cardiovascular Disparities In Mississippi: A Sociological Study Of Heart Health Literacy Among University Students, Laney Etheridge

Honors Theses

Mississippi ranks among the worst states in the United States for cardiovascular health, with high rates of heart disease, obesity, and hypertension. This thesis examines how race and gender influence heart health literacy and behavioral practices among University of Mississippi students. Utilizing a mixed-methods approach, this study combines quantitative survey data from a stratified random sample of 1,000 students with qualitative interviews from a public health professional specializing in cardiovascular health and a student heavily involved with on-campus heart health programs. The findings suggest that disparities in heart health literacy both align and differ with broader social stratification patterns observed …

Pulse Pressure, White Matter Hyperintensities, Andcognition: Mediating Effects Across The Adult Lifespan, Jade Hannan, Sarah Newman-Norlund, Natalie Busby, Sarah C. Wilson, Roger Newman-Norlund, Chris Rorden, Julius Fridriksson, Leonardo Bon, Nicholas Riccardi

Faculty Publications

Objectives: To investigate whether pulse pressure or mean arterial pressure mediates the relationship between age and white matter hyperintensity load and to examine the mediating effect of white matter hyperintensities on cognition.

Methods: Demographic information, blood pressure, current medication lists, and Montreal Cognitive Assessment scores for231 stroke- and dementia-free adults were retrospectively obtained from the Aging Brain Cohort study. Total WMH load was determined from T2-FLAIR magnetic resonance scans using the TrUE-Net deep learning tool for white matter segmentation. In separate models, we used mediation analysis to assess whether pulse pressure or MAP mediates the relationship between age and total …

Pulse Pressure, White Matter Hyperintensities, And Cognition: Mediating Effects Across The Adult Lifespan, Jade Hannan, Sarah Newman-Norlund, Natalie Busby, Sarah C. Wilson, Roger Newman-Norlund, Chris Rorden, Julius Fridriksson Ph.D., Leonardo Bonilha

Faculty Publications

Objectives: To investigate whether pulse pressure or mean arterial pressure mediates the relationship between age and white matter hyperintensity load and to examine the mediating effect of white matter hyperintensities on cognition.

Methods: Demographic information, blood pressure, current medication lists, and Montreal Cognitive Assessment scores for231 stroke- and dementia-free adults were retrospectively obtained from the Aging Brain Cohort study. Total WMH load was determined from T2-FLAIR magnetic resonance scans using the TrUE-Net deep learning tool for white matter segmentation. In separate models, we used mediation analysis to assess whether pulse pressure or MAP mediates the relationship between age and total …

Relationship Between Maternal Plasma Retinol And Provitamin A Carotenoids With Fetal And Infant Kidney Development, Anum Akbar

Theses & Dissertations

Vitamin A plays a critical role in fetal organ development. Studies suggest that maternal vitamin A deficiency affects fetal nephron numbers, potentially leading to smaller kidney sizes and an increased risk of chronic kidney disease later in life. However, human studies exploring maternal vitamin A's impact on fetal kidney development lack longitudinal data and within-cohort comparisons. Furthermore, the influence of provitamin A carotenoids (α-carotene, β-carotene, β-cryptoxanthin) on kidney size remains unexplored. This dissertation addresses these gaps by analyzing relationships between maternal and cord plasma retinol and provitamin A carotenoid concentrations with fetal and infant kidney sizes. Our prospective cohort …

Schistosoma Haematobium Infection In Ethiopian Children: Evaluating Praziquantel Efficacy, Nutritional Effects, And Diagnosis Using Flukecatcher, Louis Fok

Theses & Dissertations

Urogenital schistosomiasis continues to impact the wellbeing of hundreds of millions of people worldwide and remains a significant public health challenge across Ethiopia. Despite existing knowledge on the disease, there remain significant unanswered questions with regard to its treatment and diagnosis. This dissertation evaluated the efficacy of praziquantel at treating urogenital schistosomiasis, improving nutritional parameters among children and the performance of FlukeCatcher at detecting and determining the intensity of infection. In effecting this, a total of 977 children aged 5 through 15 from the Afar and Gambella regions of Ethiopia were screened for S. haematobium infection using urine filtration microscopy …

A Virtual Wellness Program To Enhance Well-Being For Pediatric Oncology Staff During The Covid-19 Pandemic, Karen Moody, Maria Swartz, Zachary Gresham, Martha Askins, Laura Cahalan, Pavilia Francis, Christine Geistkemper, Amy Heaton, Ruitao Lin, Melissa Melo, Alakh Rajan, Madeline Smith, Priti Tewari, Keyana R. Williams, Cheng-Han Yang, Rhonda Robert

Advances in Cancer Education and Quality Improvement

In response to the COVID-19 global health crisis and mandated social isolation, Pediatric leadership at MD Anderson Children’s Cancer Hospital was concerned for the psychological impact on its workforce and encouraged wellness programming. A grassroots wellness taskforce was assembled for the Division of Pediatrics. The task force’s primary mission was to promote the well-being of clinicians and non-clinical staff members through a broadly accessible, sustainable, and effective virtual wellness program. Guided by the Stanford Model for Professional Fulfillment, a virtual program entitled, “Weekly Wellness Webex” for Pediatrics staff was launched. Weekly Wellness Webex is a 1-hour live-streamed program with varied …

Spectrum Of Hydrogen Peroxide Ingestions With Varying Management In The Pediatric Population, Narden Gorgy

St. Chris Research Day

No abstract provided.

Comparative Study Between Laparoscopic And Non-Laparoscopic Surgeries On Blood Sugar Levels Intraoperative, Mohammed Abdul Hameed Younis

Al-Nisour Journal for Medical Sciences

Main object: This study aimed to assess the impact of laparoscopic and non-laparoscopic procedures on the blood glucose levels of patients at Baghdad Hospital and Al-imam ALI Hospital in Baghdad, Iraq.

Methodology: The study was conducted from 16 November 2023 to 2 March 2024. A total of 50 patients, aged between 15 and 58 years, were included in this study. There were 25 males and 25 females, all with an American Society of Anesthesiologists (ASA) physical status of either I or II. The patients were divided into two groups based on the type of operation they underwent, with each group …

Histological Changes Of Mesenteric Lymph Nodes Affected By Cadmium Chloride In Male Albino Rat: Experimental Study, Umalbaneen Hilal Hadi, Safa J. Al-Yassir, Warkaa M. Ali Alwattar

Al-Nisour Journal for Medical Sciences

Background: Cadmium (Cd) is a toxic heavy metal can be found in many sources, including cigarette smoke, e-cigarettes, batteries, contaminated water, plant-based foods, air, fertilizers, plastic toys, ceramics, soil and paints. the exposure to environmental factors may affect different body systems including lymphatic system.

Objectives: to investigate the effect of ingested cadmium chloride on mesenteric lymph nodes in rat.

Materials and Methods: twenty adult male albino rats were used in this study, which divided equally into two groups, on group served as control group administrated of tap water while the second group used as experimental group exposed to daily …

Shohani Save Guard (Ssg): Dietary Supplement To Support Drug Addiction Treatment, Mohammed Mahdi Salman Ghadban, Taghreed Khudhur Mohammed

Al-Nisour Journal for Medical Sciences

Shohani Save Guard (SSG) is a scientifically formulated dietary supplement designed to aid in the recovery from drug addiction, particularly methamphetamine addiction. This study explores the biochemical and biological mechanisms through which SSG's natural ingredients, including KSM-66, Panax Ginseng, Bacopa Monnieri, Green Tea, Curcumin, and other essential vitamins and minerals, work synergistically to promote recovery. The paper also reviews recent studies supporting the efficacy of these ingredients and highlights their roles in reducing addiction symptoms and improving overall health.

Synthesis, Structural Characterization, And In-Vitro Cytotoxicity Of Zinc-Levofloxacin Ligand, Khalid Ibrahim Adwan, Falah M. K. Al-Rekabi

Al-Nisour Journal for Medical Sciences

Background: This study aimed to modify levofloxacin and evaluate its cytotoxicity as well as the synthesis, characterization and physical evaluation of mixed ligand zinc complex with the third generation quinolones’ representative, levofloxacin. Levofloxacin coupled to zinc through one pyridone and one carboxylate oxygen as well as with two nitrogen atoms from the heteroligand, as demonstrated by the complexation of zinc (II) metal ion with the deprotonated ligand and heteroligand. The identification of the complex structure was carried out using Fourier Transform Infrared Spectroscopy, Hydrogen-Nuclear Magnetic Resonance, melting point, and UV–visible spectrophotometry.

Results: Binding of the zinc on the two donor …

How Does Snap Access Prior To Pregnancy Affect Maternal And Infant Health Outcomes?, Sarah Hamersma, Mitch Mcfarlane

Center for Policy Research

Consistent access to healthy food even before pregnancy can play a role in maternal and child health. The Supplemental Nutrition Assistance Program (SNAP) provides food assistance to low-income individuals, including those who do not yet have children (often classified as Able-Bodied Adults Without Dependents, or ABAWDs). Our study uses ABAWD work requirement waivers – which vary within and across counties over a 15-year-period – as a measure of SNAP access for childless women. We use this variation to investigate pre-pregnancy SNAP access and the health of mothers and their infants. Using rich, population-wide Vital Statistics data combined with county-level SNAP …

A Retrospective Study Of Childhood Meningitis And Its Risk Factors In Diyala Province, Zainab Mohamed Mahmmod

Al-Nisour Journal for Medical Sciences

Background: Viral agents are the primary cause of meningitis, a worldwide public health concern that primarily affects newborns and children. It is self-limiting and goes away in 7-10 days. With 85% of cases, enterovirus is the most prevalent etiologic agent. Summer is the peak season, and warm weather facilitates its spread. Most cases of meningitis occur in people under 30.

Aim: This study intends to assess the risk factor of meningitis in different age groups in Diyala Hospital (the Governorate of Diyala - Iraq) and identify the relation of demographical characteristics with the risk factor.

Methods: A …

A Qualitative Evaluation Of Diabetes Solutions Telehealth Coaching Services, Caroline Brock

Honors Theses

Diabetes remains a growing public health concern, particularly in underserved regions such as rural Mississippi, where barriers to healthcare access and diabetes education contribute to poor disease management. This qualitative study explores the lived experiences of 27 participants enrolled in Diabetes Solutions, a telehealth-based diabetes self-management education and support (DSMES/T) program offered by the Mississippi Diabetes Network. Using a phenomenological approach and structured interviews, the study identifies four major themes: structural benefits of the program, knowledge gained, common changes by participants, and quality of life outcomes. Participants consistently emphasized the value of personalized coaching, emotional encouragement, and practical education on …

Biomarkers That Could Explain Parasite-Induced Behavioral Alterations In The Golden Shiner (Notemigonus Crysoleucas) – Posthodiplostomum System, Laura D. Nicolas

All HCAS Student Capstones, Theses, and Dissertations

Trophically transmitted parasites require an intermediate host to be consumed and often manipulate host phenotype (i.e., morphology, physiology, and/or behavior) to increase predation risk by definitive hosts. Posthodiplostomum is a trematode with a complex life cycle involving snails as first hosts, fish as second intermediate hosts, and piscivorous birds as definitive hosts. In fish hosts, Posthodiplostomum infection has been linked to increased predation, suggesting suppression of antipredator behaviors. However, the specific physiological pathways remained unexplored and changes in the host’s neural, endocrine, and immune systems could be involved. Thus, I examined whether Posthodiplostomum infection intensity was associated with brain serotonin …

Mesoderm-Specific Transcript Has A Role In The Systemic Regulation Of Obesity, Maria J. Orellana Rosales

Thinking Matters Symposium

Mesoderm specific transcript (Mest) expression in white adipose tissue (WAT) is variable in genetically identical mice. Previous studies have shown a connection between Mest high expression and propensity for fat mass expansion. WAT and liver crosstalk has been well documented with hormone-like peptides signaling and regulating important metabolic pathways. The aim of this study is to investigate the correlation between these circulating factors and Mest expression in mice after exposure to a high fat diet (HFD). A group of 120 C57B6/J mice, males and females, were exposed to a HFD (Western Diet, 40 kcal% fat) for 4 weeks (8-12 weeks …

Expanding “Brain Games”: What Have We Learned From A Program Designed To Support Healthy Brain Aging In Older Adults?, Ella Mckinney

Honors Capstones

This study was part of a larger investigation examining the feasibility and impact of “Brain Games,” an intergenerational program designed to provide brain health education and cognitive training for healthy aging adults to maximize cognitive function and quality of life. The purpose of this project was to explore whether and how short- and long-term effects of “Brain Games” were tempered by demographic variables, including cognitive self-efficacy and socioeconomic factors. Study participants included older adults residing in two senior living centers in the DeKalb area. All participants received cognitive training and brain health education via “Brain Games”, which was offered in …

Empowering Youth Through Cooking Classes, Jamiya C. Mason

Honors Theses

Chronic health issues and poor dietary habits continue to disproportionately impact rural communities in Mississippi, especially among children. Research has shown that early exposure to healthy foods and cooking practices can positively influence lifelong health behaviors. Cooking classes have also been linked to improved food literacy, culinary confidence, and willingness to try new foods. The purpose of this study was to assess the effects of a short-term culinary program on children’s cooking self-efficacy and food behaviors in Quitman County, Mississippi.

Four cooking classes were conducted with youth (grades 4–7) in a local after-school program. Lessons included vegetable-based recipes, including zucchini …

Building Community Through Food And Health: Student Initiatives To Address Food Insecurity In Mississippi, Sarah E. Sawaya

Honors Theses

This thesis explores food insecurity in Oxford and Lafayette County, Mississippi, within the broader context of state, national, and global challenges. Over a four-year period, student-led and community organizations collaborated to design programs that addressed both food access and chronic illness prevention through education, outreach, and direct service. Community input was gathered through health screenings, campus engagement, and informal interviews with residents, which guided the development of practical tools like recipe kits, QR code-based cookbooks, and on-site health education. These efforts were rooted in local partnerships and shaped by the lived experiences of those most affected. This project demonstrates that …

Health Fairs: An Effective Approach To Health Promotion Through Community Engagement And Community-Campus Partnerships, Brookleigh Brumfield

Honors Theses

Community engagement seeks to achieve long-term outcomes through collaborating with community and campus partners to address the issues affecting the community by centering their voices, concerns, and solutions. This capstone project seeks to offer health and language access for residents in Lafayette, Pontotoc, and Union Counties, and to evaluate the health fair model from the perspective of participating community and campus partners. With this information from organizations, it will be possible to create the most efficient, beneficial health fairs in these counties. The community partner perspectives show the importance of community engagement, but also the significance for the campus as …

Lightning Assocated With More Visits To The Ed For Chest Pain, Bailee Lichter, Benjamin Aaker

Scholarship Pathways Program

This study investigates the potential association between lightning events,used as a proxy for thunder, and increased emergency department (ED) visits for chest pain and myocardial infarction (MI). Electronic medical records from Avera McKennan Hospital were analyzed for chest pain and MI diagnoses between June 1 and July 31, 2021. Lightning data within a 100-mile radius were obtained from Vaisala and cross-referenced with patient presentation times. Statistical analysis revealed a significant increase in chest pain-related ED visits within 0.5 hours and between 2.5 to 5.5 hours following lightning strikes, with p-values ranging from 0.018 to 0.047. Although a trend toward increased …

Maternal Food Insecurity And Adverse Birth Outcomes, Narysse Nicolet, Amrita Bhagia, Katie Ziegler, Lacey Mccormack, Amy Elliott, Christine Hockett

Scholarship Pathways Program

Background: Despite being a high-income country, the United States faces persistent food insecurity (FI), disproportionately affecting women of reproductive age. This study investigates the association between prenatal FI and adverse birth outcomes, specifically birth weight (BW) and gestational age (GA), among a diverse cohort of pregnant individuals in South Dakota.

Methods: A longitudinal analysis was conducted using data from 1,478 mother-infant pairs enrolled in the Safe Passage Cohort of the ECHO study. Prenatal FI was assessed using a modified USDA Household Food Security Questionnaire. Birth outcomes were analyzed using both univariate and multivariate regression models, adjusting for maternal sociodemographic and …

Utilizing Registered Dietitians To Improve Nutrition Education For Medical Students, Andee James, Pasquale Manzerra

Scholarship Pathways Program

Despite the well-established link between nutrition and chronic disease prevention, medical education continues to underemphasize nutrition training. This study explores the impact of integrating registered dietitians (RDs) into pre-clerkship medical education to enhance students’ knowledge, confidence, and perception of nutrition in clinical care. A series of optional, system-based nutrition lectures were delivered by RDs and supplemented by senior medical students who shared real-world clinical case studies. Pre- and post-session surveys assessed students’ confidence in providing dietary counseling, understanding of the physician’s and dietitian’s roles, and the perceived importance of nutrition in disease management. Results showed significant improvements across all metrics, …

The Ethical Imperative Of The Renewal Of Virtue Within The Moral Community Of Catholic Healthcare, Amanda Altobell

Electronic Theses and Dissertations

Catholic healthcare is one of the largest nonprofit organizations and providers in the United States, offering medical care to many diverse communities. The fundamental mission of Catholic healthcare is to bring about Christ’s healing ministry and live out the fundamental principle of caring for the vulnerable in pursuit of the common good. However, there have been many missteps, not only due to a more polarized and secular community but also to scandals and conflict due to previous hierarchical and rules-based anthropology that often misses the person's lived experience. Therefore, this dissertation will argue that for Catholic healthcare to survive the …

Investigating The Association Between Metabolically Healthy And Metabolically Unhealthy Obesity With Disease, Colleen Marie Cohick

Walden Dissertations and Doctoral Studies

Obesity is a global health concern, affecting individuals of all ages and ethnicities worldwide. A key factor in health concerns related to obesity is metabolic health: Obese individuals are either metabolically healthy obese or metabolically unhealthy obese, leading to different degrees of risk for cardiovascular disease and diabetes.. There is a lack of comprehensive research examining the association between metabolic health status among obese individuals and kidney, liver, and stomach diseases. This quantitative cross-sectional study was conducted to examine whether metabolic health status is a significant predictor of kidney, liver, and stomach diseases among obese individuals when lifestyle is a …

Keep Me Upright, Joscelyn C. Zimmerman, Kamrie L. Peterson

Doctor of Nursing Practice Projects: College of Nursing

Background: As our society ages, falls have emerged as a leading cause of accidental injury and death globally, significantly impacting older adults’ quality of life (Matchar et al., 2017; WHO, 2021). The consequences of falls are profound, encompassing physical injuries, psychological distress, and substantial healthcare costs. In the U.S., Medicare spends approximately $31.3 billion annually on fall-related care (Gettel et al., 2020). These statistics underscore the need for standardized fall prevention strategies in primary care.

Purpose: This Doctor of Nursing Practice (DNP) project aimed to implement a standardized systems-level process change for fall risk screening and education during Medicare Annual …

Tackling Social Stigma: An Ethical Obligation In Healthcare Intervention To Involuntary Childlessness, Persis Naumann

Electronic Theses and Dissertations

The stigma associated with involuntary childlessness has negatively affected health and well-being for several decades. This situation is particularly exacerbated for women within the Tamil socio-cultural context, resulting in feelings of shame, neglect, denial, isolation, and constituting a significant barrier to long-term access to healthcare services. Although advancements have been made in the provision of biomedical care, the psychosocial support remains inadequately addressed. Moreover, there are currently no healthcare interventions that specifically target the stigma associated with this issue, which hinders open communication with healthcare providers, delays necessary treatments, and adversely impacts overall health outcomes. The central thesis of this …

The Underdiagnosis: Addressing The Underdiagnosis Of The Female Athlete Triad And Relative Energy Deficiency In Sport, Nicholas R. Bohannon, Kayla E. Hasty, Stacie Fairley, Robert Walker

Research Day

Introduction: Many elite athletes train their whole lives to reach elite status. For another set of athletes, their sports careers were cut short for one reason or another. The underdiagnosing of the Female Athlete Triad (Triad) or Relative Energy Deficiency in Sport (RED-S) might be the reason for some athletes. A few main barriers have prevented the medical community from accurately diagnosing athletes suffering from the Triad and RED-S.

Objective: This study investigates the critical barriers to early and accurate detection of the Triad and RED-S. Key obstacles include insufficient research, limited physician education, and inadequate awareness among athletes and …