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Self-Efficacy And The Predictors For Nclex-Rn® Success For Baccalaureate Nursing Students, Linda Anne Silvestri

UNLV Theses, Dissertations, Professional Papers, and Capstones

The National Council Licensure Examination for Registered Nurses (NCLEX) is the examination that nursing graduates must pass to attain the title of registered nurse and practice professionally. Each year a substantial number of nursing graduates are unable to enter the nursing profession because of failure on the NCLEX. Failure on this examination is a concern, especially since this country desperately needs nurses. Currently, the United States (U.S.) is faced with a nursing shortage. This shortage significantly impacts the U.S. health care system and requires urgent attention so that the health care needs of the people in this country are met. …

Osteopontin And Cadherin 11 Are Novel Mediators And Drug Targets For Chronic Lung Diseases, Daniel J. Schneider

Dissertations and Theses (Open Access)

Chronic lung diseases (CLDs) are a considerable source of morbidity and mortality and are thought to arise from dysregulation of normal wound healing processes. An aggressive, feature of many CLDs is pulmonary fibrosis (PF) and is characterized by excess deposition of extracellular matrix (ECM) proteins from myofibroblasts in airways. However, factors regulating myofibroblast biology are incompletely understood. Proteins in the cadherin family contribute epithelial to mesenchymal transition (EMT), a suggested source of myofibroblasts. Cadherin 11 (CDH11) contributes to developmental and pathologic processes that parallel those seen in PF and EMT. Utilizing Cdh11 knockout (Cdh11 -/-) mice, the goal of this …

Tamoxifen: Mechanisms Of Resistance, Cyrus Mccoy Adams

Theses and Dissertations (ETD)

The role of estrogen in breast cancer has been recognized for decades. The selective estrogen receptor modulator tamoxifen was the first targeted therapy for the treatment of breast cancer. It was also the first drug approved by the FDA for the reduction of breast cancer risk. While tamoxifen has extended the lives of countless patients with breast cancer, resistance to tamoxifen remains a significant clinical problem. Work over the last two decades has greatly enhanced our understanding of the molecular mechanisms by which breast cancer cells may become resistant to tamoxifen treatment. Here I review our current understanding of the …

The Core Circadian Gene Cryptochrome 2 Influences Breast Cancer Risk, Possibly By Mediating Hormone Signaling, Richard G. Stevens

UCHC Articles - Research

As transcriptional regulators, circadian genes have the potential to influence a variety of biological pathways, including many cancer-related processes. Cryptochrome 2 (CRY2) is essential for proper circadian timing, and is a key component of the circadian regulatory feedback loop. Here, we report findings from genetic, epigenetic, loss-of-function, and transcriptional profiling analyses of CRY2 in breast cancer. Six SNPs in CRY2 were identified for genotyping in a case-control population (N=441 cases and N=479 controls), and three SNPs (rs11038689, rs7123390, and rs1401417) were significantly associated with postmenopausal breast cancer risk, with significant effect modification by menopausal status (dominant model for …

Range For Normal Body Temperature In Hemodialysis Patients And Its Comparison With That Of Healthy Individuals, Rabia Hasan, Mehreen Adhi, Syed Faisal Mahmood, Fatima Noman, Safia Awan, Fazal Akhtar, Anwar Naqvi, Adeeb Ul Hassan Rizvi

Section of Nephrology

Background/Aims: Patients with chronic kidney disease undergoing hemodialysis have an altered homeostasis leading to altered body temperatures. We aimed to determine the range for normal body temperature in hemodialysis Patients and compared it to healthy individuals. Also, we determined how much axillary temperatures differed from oral temperatures in both groups and whether axillary temperature is affected by the presence of an arteriovenous fistula (AVF) in hemodialysis Patients. Methods: Oral and axillary (left & right) temperatures were recorded using an ordinary mercury-in-glass thermometer in 400 subjects (200 hemodialysis Patients, 200 healthy individuals) at the Sindh Institute of Urology and Transplantation from …

4 Part Research Project: Cholecystokinin, Marcie Tasker

Academic Symposium of Undergraduate Scholarship

This 4 part research paper contains information on the biological molecule Cholecystokinin. The following research discusses and presents evidence of the name, history and structure of the hormone. It also discusses the different chemical reactions Cholecystokinin has in the body, the biological roles of Cholecystokinin and the importance of Cholecystokinin focusing specifically on the unexplained obesity issue of our world.

Recent Experimental And Clinical Findings In The Skeleton Associated With Loss Of Estrogen Hormone Or Estrogen Receptor Activity, Eric P. Smith, Bonny Specker, Kenneth S Korach

Ethel Austin Martin Program Publications

Studies on rodent models and rare human disorders of estrogen production or response have revealed an increased complexity of the actions of estrogen on bone. ERalpha disruption in human males results in delayed epiphyseal maturation, tall stature, trabecular thinning, marked cortical thinning, genu valgum and significantly reduced cortical vBMD, but trabecular number is preserved and there is normal to increased periosteal expansion. Aromatase deficiency results overall in a similar phenotype, although less is known about skeletal architecture. Importantly, estrogen replacement in these individuals, even if provided late in the third decade, may normalize aBMD. Less certain is whether there is …

Impact Of Nutrition Education On Dietary Habits Of Female High School Students, Rae L. Schmidt

Master's Theses and Doctoral Dissertations

The objective of this study was to explore the impact of nutrition education on the nutritional intake of female high school students. Two groups of females from Saline High School (Saline, Michigan) participated in the study. Age, height, weight, and activity level were obtained from each student in the control group (N=5) and the experimental group (N=17). Participants also completed a demographic survey and a 3-day food diary (two weekdays and one weekend day). No significant differences were found between the groups in age, weight, height, or Body Mass Index (BMI). Diet analysis of the three-day food diaries showed significant …

Physician Assistant Fort Lauderdale 2010, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

The Adl Of Sexuality: A Guide For Occupational Therapists For Elderly Clients, Autumn Edmundson, Amber Lafrenz

Occupational Therapy Capstones

Purpose: The purpose of this scholarly project was to develop a guide that would address the assessments, treatment/interventions, and discharge planning process regarding sexual health/sexuality with an elderly client. Through the use of the guide and accompanying resources it is assumed that occupational therapists will have an increased level of comfort, knowledge, and competence. This is important as Couloumbis and Miller (1994) study indicated that occupational therapists that received formal education (academically or clinical practice) addressed sexuality in the elderly 27.8% more than occupational therapists who did not have any educational experience.

Methodology: An in depth literature review was conducted …

Minimizing Injuries And Enhancing Performance In Golf Through Training Programs, Erik P. Meira, Jason Brumitt

Faculty Publications - College of Physical Therapy

Context: Golf is a popular sport, particularly in older populations. Regardless of age and skill level, golfers risk injury to the back, shoulder, wrist and hand, elbow, and knee. Because of the unique compressive, shear, rotational, and lateral bending forces created in the lumbar region during the golf swing, the primary sport-related malady experienced by amateurs and professionals is low back pain. Extrinsic and intrinsic injury risk factors have been reported in the literature. A growing body of evidence supports the prescription of strength training routines to enhance performance and reduce the risk of injury.

Evidence Acquisition: Relevant studies were …

Differences In Satiety Effects Of Alginate- And Whey Protein-Based Foods, Vicky A. Solah, Deborah A. Kerr, Cynthia D. Adikara, Xingqiong Meng, Colin W. Binns, Kun Zhu, Amanda Devine, Richard L. Prince

Research outputs pre 2011

Satiety is important in regulating food intake and has important public health significance in the control of obesity. Food containing protein and non-starch polysaccharides provides a satiety effect through various mechanisms but a comparison of the satiety effect on each has not previously been investigated. This study compared the satiety effect or reduction of hunger after consumption of (i) a whey proteinbased drink versus an alginate-based drink of the same viscosity where only the protein content differed, (ii) two alginate-based drinks differing in alginate type and viscosity, and (iii) a whey protein-based drink versus an alginate-based drink differing in protein …

Development Of Novel Ahr Antagonists, Hyosung Lee

University of Kentucky Doctoral Dissertations

Aryl hydrocarbon receptor (AHR) is a sensor protein, activated by aromatic chemical species for transcriptionally regulating xenobiotic metabolizing enzymes. AHR is also known to be involved in a variety of pathogenesis such as cancer, diabetes mellitus, cirrhosis, asthma, etc. The AHR signaling induced by xenobiotics has been intensively studied whereas its physiological role in the absence of xenobiotics is poorly understood. Despite a number of ligands of AHR have been reported thus far, further applications are still hampered by the lack of specificity and/or the partially agonistic activity. Thus, a pure AHR antagonist is needed for deciphering the AHR cryptic …

A Phenomenological Study Of Clinicians Treating Traumagenic Compulsions Resulting From Childhood Sexual Abuse, Albert Sarno

Faculty Dissertations

Various types of traumatic compulsive behaviors have been observed by practicing mental health clinicians and yet there is a lack of consensus among such clinicians for treating people in such a problematic state when there is also a history of childhood sexual abuse. Ten seasoned clinicians, each with over 15 years experience in treating patients with traumagenic compulsions and childhood sexual abuse were interviewed to explore their lived experience treating people with traumagenic compulsions due to childhood sexual abuse. A phenomenological design was used to asses the data collected in the study. The data were analyzed to determine the best …

Synthesis And Biochemical Studies On Sulfated Monomers Of Low Molecular Weight Lignins, Jenson Verghese

Theses and Dissertations

Anticoagulants are used as the first line therapy for management and prevention of thrombotic disorders. Thrombin and factor Xa have been the prime targets for regulation of the coagulation cascade. In this work, a small library of 17 benzofuran derivatives were synthesized and screened against thrombin and factor Xa. The derivatives that displayed inhibitory potential were docked on the exosite-II of factor Xa using a docking protocol that was developed in our research group. These compounds were based on the β-5 structural unit found in the oligomer -'CDSO3‘, which was prepared in our lab and was found to inhibit both …

A Truncation Mutation In Tbc1d4 In A Family With Acanthosis Nigricans And Postprandial Hyperinsulinemia, Satya Dash, Hiroyuki Sano, Justin J. Rochford, Robert K. Semple

Dartmouth Scholarship

Tre-2, BUB2, CDC16, 1 domain family member 4 (TBC1D4) (AS160) is a Rab-GTPase activating protein implicated in insulin-stimulated glucose transporter 4 (GLUT4) translocation in adipocytes and myotubes. To determine whether loss-of-function mutations in TBC1D4 might impair GLUT4 translocation and cause insulin resistance in humans, we screened the coding regions of this gene in 156 severely insulin-resistant patients. A female presenting at age 11 years with acanthosis nigricans and extreme postprandial hyperinsulinemia was heterozygous for a premature stop mutation (R363X) in TBC1D4. After demonstrating reduced expression of wild-type TBC1D4 protein and expression of the truncated protein in lymphocytes from the proband, …

Clinical And Translational Implications Of The Caveolin Gene Family: Lessons From Mouse Models And Human Genetic Disorders., Isabelle Mercier, Jean-Francois Jasmin, Stephanos Pavlides, Carlo Minetti, Neal Flomenberg, Richard G Pestell, Philippe G Frank, Federica Sotgia, Michael P Lisanti

Department of Stem Cell Biology and Regenerative Medicine Faculty Papers & Presentations

Here we review the clinical and translational implications of the caveolin gene family for understanding the pathogenesis of human diseases, including breast and prostate cancers, pulmonary hypertension, cardiomyopathy, diabetes, and muscular dystrophy. Detailed phenotypic analysis of caveolin knockout mice has served to highlight the crucial role of a caveolin deficiency in the pathogenesis of many human disease processes. Mutations in the human caveolin genes are associated with a number of established genetic disorders (such as breast cancer, lipodystrophy, muscular dystrophy, and cardiomyopathy), making the caveolins important and novel targets for drug development. The implementation of new strategies for caveolin replacement …

Clock-Cancer Connection In Non-Hodgkin’S Lymphoma: A Genetic Association Study And Pathway Analysis Of The Circadian Gene Cryptochrome 2, Richard G. Stevens

UCHC Articles - Research

Circadian genes have the potential to influence a variety of cancer-related biological pathways, including immune regulation, which may influence susceptibility to non-Hodgkin’s lymphoma (NHL). However, few studies have examined the role of circadian genes in lymphomagenesis. The current study examined Cryptochrome 2 (CRY2), a core circadian gene and transcriptional repressor, as a potential circadian biomarker for NHL. We first performed genetic association analyses of tagging SNPs in CRY2 and NHL risk using DNA samples from a population-based case-control study (N= 455 cases and 527 controls). Three SNPs were found to be significantly associated with risk of NHL when …

Contact Point, Arthur A. Dugoni School Of Dentistry

Contact Point

No abstract provided.

How Can A Video Game Cause Panic Attacks? 1. Effects Of An Auditory Stressor On The Human Brainstem, Judith Lauter, Elizabeth Mathukutty, Brandon Scott

Faculty Publications

The auditory brainstem response (ABR) was recorded during simultaneous binaural presentation of two types of sounds: 1) condensation clicks presented through in-the-ear earphones at 43.1/sec, 60dB nHL; and 2) recordings of breathing sounds, presented through supra-aural headphones, at levels adjusted by participants to be equivalent to the clicks. In alternate blocks, the breathing sounds were either: 1) a recording of quiet breathing (blocks 1, 3, 5); or 2) a recording of erratic (stressed) breathing (blocks 2, 4). The erratic breathing was modeled on a video game soundtrack in which the character was represented as running, wounded, and frightened. Four 2048-sweep …

Stress Training Efficacy In An Aviation Context, Christopher K. Mcclernon

International Symposium on Aviation Psychology - 2009

Stress is regularly introduced in training to prepare troops for stressful environments and situations, although there is very little empirical evidence for stress training's effectiveness, implementation and pedagogy. Twenty novice participants were recruited and assigned to either a stress-trained (cold pressor), treatment group or a control group. Stress training was effective at improving the treatment group’s performance during a final criterion session on an aircraft navigation task compared to the control group. In addition, the stress-trained group showed lower criterion heart rate variability, skin conductance, and subjective stress ratings compared to the control group. This research demonstrates stress training as …

Physician Assistant Jacksonville 2009, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Physician Assistant 2009, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Physician Assistant Orlando 2009, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Physical Therapy 2009, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

University Of North Dakota Division Of Sports Medicine: Historical Perpective, University Of North Dakota

UND Departmental Histories

This departmental history was written on the occasion of the UND Quasquicentennial in 2008.

Fractal Time Series Analysis Of Human Heartbeat Intervals In A Change Blindness Task, Sheldon M. Russell, Gregory J. Funke, Camilla C. Knott, Benjamin A. Knott

International Symposium on Aviation Psychology - 2009

Fractal analysis is a set of techniques used in the study of complex systems to understand patterns of variability that are often observed in non-linear and natural systems. These techniques have been successfully applied to the study of human physiology, such as gait, heart rate variability, and respiration (West, 2004). Understanding variability in physiological measures may provide insight into human performance, individual workload, and stress. As an exploration of the possible contributions of fractal analysis to human performance, heart rate data from an existing research study was re-analyzed using methods common in fractal analysis of time series data. Results indicate …

Vascular Sonography 2009, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

The Potential For Nutrigenomics In Prevention Of Metabolic Syndrome, J. David Gangemi, Dana King

Journal of the South Carolina Academy of Science

No abstract provided.

Insights Into Expression, Cellular Localization, And Regulation Of Supernatant Protein Factor, A Putative Regulator Of Cholesterol Biosynthesis, Elzbieta Ilona Stolarczyk

University of Kentucky Doctoral Dissertations

SPF (Supernatant Protein Factor) is a cytosolic protein that stimulates at least two enzymes in the cholesterol biosynthetic pathway: squalene monooxygenase and HMGCoA reductase. The mechanism of action has not been established but may be related to lipid transfer between intracellular membranes.

There are three human genes for SPF: SEC14L2 (SPF1), SEC14L3 (SPF2) and SEC14L4 (SPF3). The present study differentiates these closely related genes by evaluating their tissue-specific and relative expression levels. SPF1 mRNA was found to be most abundant in liver, mammary gland and stomach. SPF2 showed negligible expression in all tissues tested; SPF3 expression pattern was similar to …