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Molecular Level Interaction Of Human Fibroblast Growth Factor-1 (Hfgf-1) With Phloridzin, Rammohan Paripelly

Masters Theses & Specialist Projects

Fibroblast growth factors (FGFs) are a family of growth factors which includes twenty three proteins. FGFs work as modulators for various cellular activities like mitosis, differentiation and survival. Among the FGF family, human fibroblast growth factor-1 (hFGF-1), which is also known as acidic fibroblast growth factor, is a potent angiogenic agent, involved in the formation of new blood vessels in various tissues. hFGF-1 is regarded as a prototype of the FGF family. It serves as one of the potential targets in tumor inhibition and obesity due to its involvement in new blood vessel formation in cancerous regions and adipose tissues. …

Electronic Word Of Mouth On Twitter About Physical Activity In The United States: Exploratory Infodemiology Study, Ni Zhang, Shelly Campo, Kathleen F. Janz, Petya Eckler, Jingzhen Yang, Linda G. Snetselaar, Alessio Signorini

Faculty Research, Scholarly, and Creative Activity

Background:
Twitter is a widely used social medium. However, its application in promoting health behaviors is understudied.
Objective:
In order to provide insights into designing health marketing interventions to promote physical activity on Twitter, this exploratory infodemiology study applied both social cognitive theory and the path model of online word of mouth to examine the distribution of different electronic word of mouth (eWOM) characteristics among personal tweets about physical activity in the United States.
Methods:
This study used 113 keywords to retrieve 1 million public tweets about physical activity in the United States posted between January 1 and March 31, …

Hot Topics In Education, Michael Hartman

Faculty Works: AHS (2004-2023)

Presented at Society of Diagnostic Medical Sonography Annual Conference (2013) in Las Vegas, NV

White Paper On Pcbs In The Built Environment, Andre Barton Ashley Jr., Cheryl Marcham, Et Al.

Publications

Dr. Marcham was part of the 9-member team that wrote this paper. Polychlorinated biphenyls (PCBs) are a group of man-made chemicals associated with a potential risk to human health and the environment. They were used in many building materials, particularly caulking, grout, expansion joint material and paint, from approximately 1950 to 1978. Both the U.S. Environmental Protection Agency (EPA) and the Agency for Toxic Substances and Disease Registry (ATSDR) have published extensive material evaluating human health impacts from exposure to PCBs. The apparent public health risks, including developmental effects in children, reproductive effects and long-term risks for cancer development, have …

What Critical Resources Do Hispanic Women Of Childbearing Age In Utah Need To Promote Adequate Health Care Practices?, Teresa Paredes, Dr. Ana Birkhead

Journal of Undergraduate Research

The health care practices of Hispanic childbearing age women in Utah affect the overall health care system in Utah. We believe immigrant Hispanic women lack resources (i.e. education, cultural, transportation) to take care of their health and their families. My mentor and I believe the lack of these resources influence Hispanic women’s health status and access to adequate health care. It is crucial for immigrant Hispanic women in Utah to obtain culturally sensitive resources in their communities that will help them learn how to care for their own health and the well-being of their families.

Factors And Convergent Validity Of The Pet Attachment And Life Impact Scale (Pals), Lisa Demarni Cromer, M. Rose Barlow

Psychological Sciences Faculty Publications and Presentations

Human-animal interaction (HAI) provides benefits for humans. Emotional attachment to pets is a possible mechanism for benefits but there is no standard operationalization for “attachment to pets.” The study presented here (N = 651) uses a pet attachment measure based on qualitative research about benefits of pets. This measure, the Pet Attachment and Life Impact Scale (PALS), has four factors that measure Love, Regulation, Personal Growth, and Negative Impacts. We present exploratory factor analysis and confirmatory factor analysis of the instrument. We then examine convergent validity with four a priori derived measures of pet attachment (Anthropomorphism Scale, CENSHARE PAS, …

Bioengineering The Expression Of Active Recombinant Human Cathepsin G, Enteropeptidase, Neutrophil Elastase, And C-Reactive Protein In Yeast, Eliot T. Smith

Electronic Theses and Dissertations

The yeasts Pichia pastoris and Kluyveromyces lactis were used to express several recombinant human proteins for further biochemical characterization. Two substitution variants of recombinant human enteropeptidase light chain (rhEPL) were engineered to modify the extended substrate specificity of this serine protease. Both were secreted as active enzymes in excess of 1.7 mg/L in P. pastoris fermentation broth. The substitution variant rhEPL R96Q showed significantly reduced specificities for the preferred substrate sequences DDDDK and DDDDR; however, the rhEPL Y174R variant displayed improved specificities for these substrate sequences relative to all other reported variants of this enzyme. The neutrophil serine proteases human …

The Effect Of Shear Stress, Potassium, And Adenosine On Α-1 Adrenergic Vasoconstriction Of Rat Soleus Feed Arteries, Tanner J. Heckle, Jeffrey Jasperse

Featured Research

During exercise, blood flow increases to the working skeletal muscle primarily because of dilation of the arteries and arterioles feeding the muscle. Sympathetic nerve activity also increases during exercise, augmenting the release of the neurotransmitter norepinephrine (NE) at the arterial wall and into the blood. NE acts to constrict blood vessels; however, arteries and arterioles within contracting skeletal muscle dilate despite the increased NE present. This has led to the concept of functional sympatholysis (4), the idea that a chemical released from contracting skeletal muscle interferes with NE signaling. NE acts by binding to adrenergic (alpha and beta) receptors, and …

The Identification And Classification Of Flow Disruptions In The Operating Room During Laparoscopic Cholecystectomy And Open Hernia Repair Procedures, Sacha N. Duff

Doctoral Dissertations and Master's Theses

The operating room is one of the most complex work environments in healthcare; it is estimated that at least 7% of adverse events due to medical error occur in the operating room. Flow disruptions are events that cause a "break" in the primary surgical task, or the loss of any team member's situational awareness. An empirical link between flow disruptions and surgical errors in the OR has been established; therefore, identifying and classifying the specific flow disruptions present during different types of procedures should facilitate the development of evidence-based interventions. The goal of this study was to identify and classify …

The Public Health Impact Of Maternal Smoking Cessation During Pregnancy : The San Bernardino County Experience, Michael Batech

Loma Linda University Electronic Theses, Dissertations & Projects

Most studies of maternal tobacco cessation during pregnancy have estimated measures of effect that can be useful in identifying the exposure as an etiologic risk factor in maternal and child health. However, in the case of maternal tobacco use there is overwhelming evidence for a causal role in adverse infant outcomes, and public health needs to focus on measures of potential impact in order to better prioritize and allocate resources toward interventions. The aims of this dissertation were: 1) to investigate the public health impact of smoking cessation during pregnancy among mothers giving birth in San Bernardino County, California; and …

The Effect Of Skeletal Muscle Mass On Basal Metabolic Rate In College-Age Males 2013, Chase Vaughn

Master's Theses

There are many misconceptions within the fitness community. One such misconception is that an increase in muscle mass will have a large increase in basal metabolic rate, yet this may not be the best way for successful weight loss. The purpose of this study was to determine the strength of the correlation between skeletal muscle mass and basal metabolic rate. The hypothesis tested was that basal metabolic rate is strongly correlated with skeletal muscle mass. The participants were college-aged males (n =17). Skeletal muscle mass (SMM) was estimated using the skin-fold circumference model (SFCM): SMM (kg) = Ht (0.00744 CAG2 …

Ovarian Modifications In Mice Exposed To Whole-Body Irradiation., Jacob Marion Poole

Undergraduate Honors Theses

This experiment was designed to determine the involvement of varying levels of whole-body irradiation on ovarian follicular and corpora luteal development in mice. Previous research has indicated reduced counts of ovarian follicles and corpora lutea in mice flown in space. These differences may be the result of microgravity, increased exposure to radiation, or some combination of both. Fifty-six mice were divided into three groups (apocynin-treated, nox2 knockout, and wild-type control) before exposure to 0 Gy, 0.5 Gy, or 2.0 Gy radiation. The tissues were harvested, preserved, run through the appropriate paraffin embedding procedures, serially sectioned, mounted on microscope slides, and …

Aerodynamic And Acoustic Features Of Vocal Effort, Allison Rosenthal

Speech-Language Pathology - Theses

Many voice disorders are associated with an effortful voice; however, there have been very few studies that have examined the physiological changes that contribute to this sense of effort. Determining the factors that contribute to change in vocal effort may help clinicians to effectively target these variables when working with people with voice disorders so that voice improvement is accompanied by decreased vocal effort after treatment. Prior research has shown that alterations in aerodynamic and acoustic variables are often associated with voice disorders involving increased muscular effort, and change in these variables is correlated with abnormal voice qualities. The current …

Structured Debriefing And Students' Clinical Judgment Abilities In Simulation, Bette Mariani, Mary Ann Cantrell, Colleen H. Meakim, Patricia Prieto, Kristina Dreifuerst

College of Nursing Faculty Research and Publications

Background

Debriefing is a critical component of clinical simulation, yet there are limited studies that demonstrate the outcomes of debriefing on learners' clinical judgment.

Method

Using the Lasater Clinical Judgment Rubric, this mixed-method study examined the effects of structured debriefing after 2 clinical simulation experiences on 86 junior-level baccalaureate nursing students' clinical judgment. Debriefing for Meaningful Learning© was the method used for the structured debriefing sessions.

Results

The mean clinical judgment scores of the intervention group were higher and improved more over time compared with the mean scores of those in the control group; however, the differences were not statistically …

The Effects Of Selected Drugs On The Memory Recall Of Sleep Deprived Mice, Jenn Pauldurai

Capstone Research Projects

Humans often make use of the neurotransmission altering effects of drugs such as caffeine, ephedrine, and ethanol. These drugs induce changes in memory and learning ability, specifically when used for sleep deprivation. English white mice (Mus musculus) have been shown to exhibit similar cognitive changes when administered drugs while sleep deprived. A sample of 20 mice was divided into three experimental groups (each group receiving a different drug) and one control group. Maze-testing demonstrated that mice performance decreased with sleep deprivation (Treatment-1) but all groups returned to baseline performance when injected (IP) with selected drugs (Treatment-2), regardless of …

Angiotensin Type 1 Receptor Resistance To Blockade In The Opossum Proximal Tubule Cell Due To Variations In The Binding Pocket, Ravi Nistala, Bradley T. Andresen, Lakshmi Pulakat, Alex Meuth, Catherine Sinak, Chirag Mandavia, Thomas Thekkumkara, Robert C. Speth, Adam Whaley-Connell, James R. Sowers

HPD Articles

Blockade of the angiotensin (ANG) II receptor type 1 (AT(1)R) with angiotensin receptor blockers (ARBs) is widely used in the treatment of hypertension. However, ARBs are variably effective in reducing blood pressure, likely due, in part, to polymorphisms in the ARB binding pocket of the AT(1)R. Therefore, we need a better understanding of variations/polymorphisms that alter binding of ARBs in heterogeneous patient populations. The opossum proximal tubule cell (OKP) line is commonly used in research to evaluate renal sodium handling and therefore blood pressure. Investigating this issue, we found natural sequence variations in the opossum AT(1)R paralleling those observed in …

Holobiont Nutrition: Considering The Role Of The Gastrointestinal Microbiota In The Health Benefits Of Whole Grains, Jens Walter, Ines Martinez, Devin J. Rose

Food for Health: Publications

Intake of whole grains and other food products high in dietary fiber have long been linked to the prevention of chronic diseases associated with inflammation. A contribution of the gastrointestinal microbiota to these effects has been suggested, but little is known on how whole grains interact with gut bacteria. We have recently published the first human trial that made use of next-generation sequencing to determine the effect of whole grains (whole grain barley, brown rice or a mixture of the two) on fecal microbiota structure and tested for associations between the gut microbiota and blood markers of inflammation, glucose and …

The Effect Of Pointe Shoe Toe Box Shape On Proprioception In Novice Ballet Dancers, Robert Cox, Valerie W. Herzog

Internet Journal of Allied Health Sciences and Practice

Purpose: The purpose of this study was to determine the short-term effect of a pointe shoe toe box shape on proprioception in novice ballet dancers. Methods: Thirty-six female subjects completed the study (age = 13.2 + 2.2 years, height = 156.4 + 11.5 cm, weight = 46.6 + 9.4 kg). Subjects were assigned randomly to one of two groups. One group of 18 subjects was assigned to the tapered toe box pointe shoe, and the other group of 18 subjects was assigned to the square toe box pointe shoe. Subjects in each group were given a choice of any variation, …

Topical Menthol, Ice, Peripheral Blood Flow, And Perceived Discomfort, Robert V. Topp, Elizabeth R. Ledford, Dean E. Jacks

College of Nursing Faculty Research and Publications

Context : Injury management commonly includes decreasing arterial blood flow to the affected site in an attempt to reduce microvascular blood flow and edema and limit the induction of inflammation. Applied separately, ice and menthol gel decrease arterial blood flow, but the combined effects of ice and menthol gel on arterial blood flow are unknown.

Objectives : To compare radial artery blood flow, arterial diameter, and perceived discomfort before and after the application of 1 of 4 treatment conditions.

Design : Experimental crossover design.

Setting : Clinical laboratory.

Participants or Other Participants : Ten healthy men, 9 healthy women (mean …

A Comparison Of Daily Consumption Of Artificial Dye-Containing Foods By American Children And Adults, Carol Christine Bell

Master's Theses and Doctoral Dissertations

Children with developing nervous systems might be at greater risk for any potential neurobehavioral effects of color additives widespread in many foods. This study thus examined whether children consumed foods containing color additives more frequently than adults. Twenty-one adults (aged 18-60) and parents of 14 children (aged 4-7) with regular eating patterns kept detailed food records for five days. Diets were analyzed for foods containing the dyes Red #3, Red #40, Yellow #5, Yellow #6, Blue #1, Blue #2 and Green #3 by comparing ingredient labels found in grocery stores and online. The number of daily dye exposures was significantly …

Effect Of Passive Vibration On Skin Blood Flow In Good Glycemic Control And Poor Glycemic Control Type 2 Diabetics, Kanikkai Steni Balan Sackiriyas

Loma Linda University Electronic Theses, Dissertations & Projects

Microcirculation regulated by the sympathetic system and vascular endothelium plays a significant role in the homeostasis of temperature and wound healing. Damage to the autonomic nervous system and endothelial system resulting from aging and diabetes decreases the potential of wound healing. Insulin resistance and impaired wound healing associated with type 2 diabetes can lead to diabetic foot ulceration (DFU). Factors such as the increased insulin resistance, impaired wound healing and DFU can increase the risk of amputation in type 2 diabetics (T2D). In research, passive vibration (PV) was effective in increasing skin blood flow (SBF) in healthy individuals as well …

Physician Assistant Fort Lauderdale 2013, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

General And Vascular Sonography 2013, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Nanosecond Pulsed Electric Field (Nspef) Ablation As An Alternative Or Adjunct To Surgery For Treatment Of Cancer, Ru Chen, Xinhua Chen, Stephen J. Beebe

Bioelectrics Publications

Surgery as resection or transplantation remains a fundamental means for cancer treatment and often offers an opportunity for a cure. However, surgery is not always possible because of tumor proximity to blood vessels or ducts or when a patient is not healthy enough to undergo surgery. Application of nanosecond pulsed electric fields (nsPEFs) is a new approach to treat cancer using pulse power technology that was originally designed for military purposes. This novel approach deposits extremely short pulses of high power, low energy electric fields into malignant tissues using electrodes to encompass tumors. Pre-clinical studies show that treatments are effective …

Implementation And Model To Model Intercomparison Of 12 Heat Stress Metrics, Jonathan Robert Buzan

Open Access Theses

Earth system models simulate the dynamics of the most complex systems on our planet with some success. Despite the overwhelming sophistication of these models, which include dynamical interactions of ocean, atmosphere, vegetation, ice, and land-surface properties, they fail to include the most important element. People. Humans are also a complex physical-biological system and coupling of human physiology within an Earth Systems Modeling framework is challenging. This thesis presents results that tackle one particular component of human physiological climate interaction--a representation of heat stress on human physiology. Twelve different metrics were implemented and analyzed. These metrics represent a variety of philosophical …

Role Of Satellite Cells In Long Term Fiber Type Shifts, Honglu Liu

Lewis Honors College Capstone Collection

Muscle fiber type shifts in respect to satellite cells, muscle stem cells, are not well understood currently. The Peterson Lab has generated a mouse model (PAX7-DTA) that ablates satellite cells to determine if these muscle stem cells contribute to mouse muscle fiber type changes over an eight week period. In the study, control and satellite-cell-ablated mouse groups were split into control and overload groups (via synergist ablation surgery) and placed under similar environmental conditions. Eight weeks post-experiment, muscles were dissected to obtain the plantaris muscles of animals from all groups. Muscle cross-sections obtained were immunohistochemically stained, imaged, quantified by fiber …

Complex Regional Pain Syndrome: A Review Of Current Treatments, Yosef Lewis

The Science Journal of the Lander College of Arts and Sciences

Complex Regional Pain Syndrome (CRPS) is a syndrome that develops infrequently in patients that experience a minor or severe trauma to a bodily extremity. CRPS has two subtypes; Type-I and II, both are clinically characterized by hyperalgesia. During its acute stage, CRPS hyperalgesia is clinically characterized by edema in the subcutaneous tissues of the epidermis, allodynia, and localized bone resorption. In the later chronic stage, hyperalgesia is aroused by the disregulation of blood flow to the extremity and permanent dystonic and trophic changes to the skin. Because the epidemiology and central causation of CRPS remains unknown until today, health professionals …

The Silhouettes Of Autism, Chloe J. Dobbert

CMC Senior Theses

My passion as a student at the Claremont Colleges is to help children with Autism Spectrum Disorder grow and learn as normal children and to help prepare them for life outside the Autism Center at Claremont McKenna College. In my thesis project, I am exploring the concept of silhouettes through photography and my perceptions of the stories told to me by the children I teach. Esthetically, I am inspired by Kara Walker’s installation of large cutout silhouettes but I am using different mediums to accomplish my project: Artistically, I am inspired by the detailed descriptions of the obsessive stories and …

Molecular Mechanisms Related To Endotoxemia In Primary Human Cardiomyocytes In Culture, Atijah J. Collins

PCOM Biomedical Studies Student Scholarship

Cardiovascular disease (CVD) is the leading cause of death in the United States and has been for the past 80 years. Development of novel therapeutic agents to address the large number of CVD deaths requires an in depth understanding of the structural and functional properties of human cardiomyocytes. Over the last few years we have been developing an in vitro paradigm to assess molecular cardiodynamics in Primary Human Cardiomyocyte in culture (PHCC). We tested the hypothesis whether endotoxemia would exhibit a marked decrease in contractile proteins and cause apoptosis in PHCC. In the current series of experiments, we induced endotoxemia …

Enhancing The Uptake Of Learning Through Simulation In Health, Cobie Rudd

Research outputs 2013

The initial reason that a simulated learning environment (SLE) was pursued was to offer university-based health students a safe and authentic environment in which to learn and practise their skills. Since that time, some eight years later, experience has shown that an SLE needed multiple dimensions to its work, based on evidence. In addition, a new approach to applying and integrating learning through simulation within health curricula, that was replicable and affordable, was required...