Digital Commons Network^™

Loss Of Situational Awareness During Commercial Flight Over Colombian Mountains, Oscar Sarmiento Mejia

International Symposium on Aviation Psychology - 2021

No abstract provided.

Psychological Aspects In Pilot Training: Cognition And Human Factors, Shagun Gupta

International Symposium on Aviation Psychology - 2021

Introduction-International Civil Aviation Organization’s (ICAO) SHELL model was designed to study and investigate the way the pilot interacted with the various dimensions of the model. Aim-The present study aimed to explore psychological aspects while flying using the dimensions of ICAO’s SHELL model of aviation. Methods-The study followed the qualitative research paradigm. The sample consisted of 9 (Males =4, Female =5) student trainee pilots in the age range of 18 – 21 years. They were subjected to in-depth interviews which lasted for around 30 minutes. The data were analyzed using the thematic network of analysis. Results-The results show that in the …

Leptin Activation Of Metabolically-Related Hypothalamic Neurons, Kailee Hixon

Undergraduate Honors Theses

Obesity is often associated with multiple other clinical conditions, including hypertension and cardiovascular disease. Currently, more than one-third of the world’s population is classified as obese. Leptin is a neuropeptide that is released from adipose cells and is responsible for reducing appetite and increasing metabolism. Leptin also has a role in the activation of cardiovascular and metabolic pre-sympathetic neurons and has been reported to increase blood pressure and heart rate. Thus, understanding the activation of the autonomic nervous system by leptin has implications in the development and safety of drugs to avoid activation of cardiovascular pre-sympathetic neurons. This is important …

Application Of An Evidence-Based, Out-Patient Treatment Strategy For Covid-19: Multidisciplinary Medical Practice Principles To Prevent Severe Disease☆, Elliot M. Frohman, Nicole R. Villemarette-Pittman, Adriana Rodriguez, Robert Glanzman, Sarah Rugheimer, Oleg Komogortsev, Scott S. Zamvil, Roberto A. Cruz, Thomas C. Varkey, Ashley N. Frohman

School of Medicine Publications

The COVID-19 pandemic has devastated individuals, families, and institutions throughout the world. Despite the breakneck speed of vaccine development, the human population remains at risk of further devastation. The decision to not become vaccinated, the protracted rollout of available vaccine, vaccine failure, mutational forms of the SARS virus, which may exhibit mounting resistance to our molecular strike at only one form of the viral family, and the rapid ability of the virus(es) to hitch a ride on our global transportation systems, means that we are will likely continue to confront an invisible, yet devastating foe. The enemy targets one of …

Improving The Nurse Patient Assignment Process On A Medical Surgical Unit, Kevin K. Mcewan

Doctor of Nursing Practice Projects

Background: Nurse patient assignments on an adult medical surgical unit at a community hospital are often accomplished with inconsistent processes and rationales. Each charge nurse utilizes individualized processes to determine which patients will be best teamed-up and assigned to the available nurses. There are frequently no acuity measurements system or set criteria by which the number or types of patients can or should be assigned to any given nurse, nor are staff skill or competency considered in the assignment process.

Project Design: A pilot project was conducted on a medical/surgical unit. The project utilized the American Association of Critical Care …

Acute Mountain Sickness, Efrain De Leon Angon

Student Publications

Overview of Acute Mountain Sickness including Diagnosis, risk factors and treatment/prevention, as well as the pathophysiology effects of AMS.

Activity-Dependent Regulation Of Extracellular Ube3a In A Novel Angelman Syndrome Rat Model, Andie Dodge

USF Tampa Graduate Theses and Dissertations

Angelman Syndrome (AS) is a rare genetic and neurologic disorder affecting approximately 1 in every 15,000 people. This disorder is characterized by seizures, absence of speech, motor and cognitive deficits, ataxia, and notably an abnormal happy demeanor with frequent smiling and laughter. A neuron-specific loss of function of the maternal allele of UBE3A, encoding for an E3 ubiquitin ligase, leads to the manifestation of AS. There are currently no cures for AS and few therapeutic options to abate symptoms. Although much investigation is required, research using the null mutation AS mouse model suggests a plausible case for pharmacological intervention.

Major …

A Millifluidic Perfusion Cassette For Studying The Pathogenesis Of Enteric Infections Using Ex-Vivo Organoids, Reid L Wilson, Sarah A Hewes, Anubama Rajan, Shih-Ching Lin, Carolyn Bomidi, Takanori Iida, Mary K Estes, Anthony W Maresso, K Jane Grande-Allen

Faculty, Staff and Students Publications

To generate physiologically-relevant experimental models, the study of enteric diarrheal diseases is turning increasingly to advanced in vitro models that combine ex vivo, stem cell-derived "organoid" cell lines with bioengineered culture environments that expose them to mechanical stimuli, such as fluid flow. However, such approaches require considerable technical expertise with both microfabrication and organoid culture, and are, therefore, inaccessible to many researchers. For this reason, we have developed a perfusion system that is simple to fabricate, operate, and maintain. Its dimensions approximate the volume and cell culture area of traditional 96-well plates and allow the incorporation of fastidious primary, stem …

Uterine Contractions In Rodent Models And Humans, Manasi Malik, Michelle Roh, Sarah K England

2020-Current year OA Pubs

Aberrant uterine contractions can lead to preterm birth and other labour complications and are a significant cause of maternal morbidity and mortality. To investigate the mechanisms underlying dysfunctional uterine contractions, researchers have used experimentally tractable small animal models. However, biological differences between humans and rodents change how researchers select their animal model and interpret their results. Here, we provide a general review of studies of uterine excitation and contractions in mice, rats, guinea pigs, and humans, in an effort to introduce new researchers to the field and help in the design and interpretation of experiments in rodent models.

Characteristics Of Physiology And Physiology-Related Pre-Health Degree Programs In The Physiology Majors Interest Group, Yvonne Ogrodzinski, Erica A. Wehrwein, Kevin Kelly, James M. Poteracki, Valerie Vanryn, Anne R. Crecelius

Health and Sport Science Faculty Publications

The Physiology Majors Interest Group (P-MIG), a grassroots organization of educators, has collected data on the history and characteristics of Physiology and highly related undergraduate programs (ex: Human Biology, Pre-Medicine, Biomedical Sciences, etc.) that serve a common population of prehealth students. Data was obtained as part of an online survey sent out to P-MIG conference attendees at the 2017-2019 annual meetings (n=30). Participating institutions indicate that 25.9% have degrees called Physiology aligned with 28% being housed in a department of physiology, 75.9% are a Bachelor of Science program, 34.9% are affiliated with a College of Arts and Sciences, and 80% …

Costs And Benefits Of Physical Therapy Program Implementation For Air Force Fighter Pilots, Christian G. Erneston

Theses and Dissertations

Air Force fighter pilots face risks associated with neck and spine injuries sustained while operating fighter aircraft. Studies from the flying and medical communities indicate that muscle-strengthening prehabilitative care may decrease the risk of flying related injuries in high performance aircraft pilots. For this reason, the U.S. Air Force provided $24.9M to implement the Optimizing the Human Weapon System (OHWS) program. The program provides physical therapy and strength training to fighter pilots in participating units at twenty-one Air Force bases with the intent of reducing injury rates and time out of the cockpit. From a healthcare perspective there is interest …

Establishing A Mechanistic Link Between Disturbed Flow And Aneurysm Formation In A 3d Cerebral Bifurcation Model, Nesrine Bouhrira

Theses and Dissertations

The effect of disturbed flow profiles on the endothelium have been studied extensively in systemic vasculature, but less is known about the response of the blood-brain barrier (BBB) to these flow regimes. Here we investigate the effect of steady and pulsatile disturbed flow on the integrity of the BBB using a three-dimensional, perfusable bifurcation model consisting of a co-culture of endothelial cells with mural and glial cells. Experimental flow patterns predicted by computational fluid dynamics mimic in vivo flow regimes, specifically the presence of a recirculation zone immediately downstream of the bifurcation reveal periodic changes in the instantaneous shear stress …

Aacp Basic Resources For Pharmacy Education, Jason Guy, Ivan Portillo, Robert D. Beckett, Kayce Gill, Kimberly Mitchell, Jill Nissen, Priya Shenoy

Library Association/Organization Work

"The AACP Basic Resources for Pharmacy Education is produced as a guide for those developing or maintaining the library collections that serve colleges and schools of pharmacy. The goal of the Basic Resources list is to make recommendations of books and other works to be included in pharmacy libraries, but not all titles are required to be purchased. Each pharmacy college has its own mission and its own program(s), and so each college’s library collection must reflect that mission and support the college’s program(s). Excellent library collections are built by knowledgeable librarians and drug information specialists using their professional judgment …

A Timely Call To Arms: Covid-19, The Circadian Clock, And Critical Care, Jeffrey Haspel, Minjee Kim, Phyllis Zee, Tanja Schwarzmeier, Sara Montagnese, Satchidananda Panda, Adriana Albani, Martha Merrow

2020-Current year OA Pubs

We currently find ourselves in the midst of a global coronavirus disease 2019 (COVID-19) pandemic, caused by the highly infectious novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we discuss aspects of SARS-CoV-2 biology and pathology and how these might interact with the circadian clock of the host. We further focus on the severe manifestation of the illness, leading to hospitalization in an intensive care unit. The most common severe complications of COVID-19 relate to clock-regulated human physiology. We speculate on how the pandemic might be used to gain insights on the circadian clock but, more importantly, on …

Experimental Pharmacotherapies In Models Of Alcohol Addiction, Mousumi Akter Sumi

Theses and Dissertations

The USA faces $220 billion economic loss and eighty thousand deaths per year due to alcohol abuse while affecting more than 15 million people, making it the third largest life-style related cause of death. The U.S. FDA has approved four medications namely, disulfiram, acamprosate, oral naltrexone, and injectable long-acting naltrexone. These existing drugs are trashed with side effects, have a low success rate, indicating a demand for new potential drugs. We studied the effects of the CB1 negative allosteric modulator, PSNCBAM-1, and the dopamine D4 receptor antagonist, L-745,870 in mouse models of alcohol addiction. PSNCBAM-1 did not significantly reduce CPP …

Knowledge Network Embedding Of Transcriptomic Data From Spaceflown Mice Uncovers Signs And Symptoms Associated With Terrestrial Diseases, Amber M. Paul, Charlotte A. Nelson, Ana Uriarte Acuna, Ryan T. Scott, Atul J. Butte, Egle Cekanaviciute, Sergio E. Baranzini

Publications

There has long been an interest in understanding how the hazards from spaceflight may trigger or exacerbate human diseases. With the goal of advancing our knowledge on physiological changes during space travel, NASA GeneLab provides an open-source repository of multi-omics data from real and simulated spaceflight studies. Alone, this data enables identification of biological changes during spaceflight, but cannot infer how that may impact an astronaut at the phenotypic level. To bridge this gap, Scalable Precision Medicine Oriented Knowledge Engine (SPOKE), a heterogeneous knowledge graph connecting biological and clinical data from over 30 databases, was used in combination with GeneLab …

Role Of Na/K-Atpase Non-Enzymatic Signaling In Renal Proximal Tubule Sodium Transport, Shreya Tapan Mukherji

Theses, Dissertations and Capstones

The renal proximal tubule (RPT) is the center stage for renal handling of Na+ , a potent determinant of systemic Na+ and volume homeostasis in health and disease. In the RPT, through its classic ion-pumping function, Na + /K+ -ATPase (NKA) generates the Na+ gradient that drives apical Na+ absorption, mostly through Na+ /H+ exchanger (NHE3). In contrast, pharmacological evidence suggests that the activation of the NKA non-enzymatic signaling function, through Src and other signaling partners, triggers a cellular redistribution of NKA and NHE3 that decreases transcellular Na+ flux in cultured RPT cells. However, the physiological relevance of the nonenzymatic …

Physician Assistant_Fort Lauderdale_2021, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

The Influence Of Infant Formula On The Growth Of Commensal And Pathogenic Streptococcus Species In The Infant Oral Cavity, Geneva Waynick

Undergraduate Honors Theses

The oral microbiome is a complex community of microorganisms that can both reflect and greatly influence the health of the human host. A number of diseases are associated with dysbiotic oral microflora in infants and children, including dental (e.g. dental caries, gingivitis, and periodontal disease), and gastrointestinal diseases (e.g. pediatric appendicitis, celiac disease, and pediatric inflammatory bowel disease). A variety of factors can influence the composition of the oral microbial community in infants, including gestation length, mode of delivery, feeding method, and diet. This study focuses on the effects of diet on the growth of a commensal bacterium (Streptococcus …

Effect Of Remaining Dentin Thickness And Primer Application Technique On Microtensile Bond Strength, Paphawee Somrit

Chulalongkorn University Theses and Dissertations (Chula ETD)

To evaluate the effect of primer application techniques, type of adhesives and remaining dentin thicknesses on microtensile bond strength (µTBS) of 4 different adhesive systems, 112 Flat occlusal surfaces of sound third molar were randomly allocated into 16 groups based on 2 remaining dentin thicknesses (RDT), 2 application techniques and 3 adhesive systems, e.g., Three step etch-and-rinse (Optibond FL; OFL), Two step self-etch (Clearfil SE Bond; CSE), and Universal adhesive (Single Bond Universal; SB). SB was applied in either etch-and-rinse (ER) or self-etch (SE) mode. Simulated pulpal pressure was performed during bonding procedure and 6-month water storage (37 oC). After …

Formulation Development And Evaluation Of Spray-Dried Astaxanthin-Loaded Self-Microemulsifying Delivery Systems In Tablets, Wai Thet Aung

Chulalongkorn University Theses and Dissertations (Chula ETD)

An antioxidant activity of astaxanthin (AST) is one of the desirable bioactive properties for nutraceutical and pharmaceutical products. However, poor aqueous solubility and high possibility of degradation of AST limit its efficacy of oral absorption and bioavailability. Therefore, the aim of this study was to develop and optimize the spray-dried astaxanthin-loaded self-microemulsifying delivery system (SMEDS) in tablets to improve solubility, dissolution, and bioavailability of AST. By using a mixture design, liquid AST SMEDS (L-AST SMEDS) formulations containing rice bran oil, Kolliphor® RH40, and Span® 20 were optimized based on the desirability function. The optimal L-AST SMEDS composed of rice bran …

Effect Of Hyperparathyroidism On Coagulation: A Global Assessment By Modifiedrotation Thromboelastogram (Rotem), Göknur Yorulmaz, Ahmet Toygar Kalkan, Aysen Akalin, Eli̇f Sevi̇l Alagüney, Eren Gündüz, Bartu Badak, Betül Aydin Buyruk, Medi̇ne Nur Kebapçi, Fatma Belgi̇n Efe, Muzaffer Bi̇lgi̇n, Olga Meltem Akay

Turkish Journal of Medical Sciences

Background/aim: Hyperparathyroidism is an endocrine disorder characterized by hypercalcemia. Because of calcium?s effects on parathyroid glands, bone, intestines, and kidneys, it has an important place in homeostasis. The results of studies regarding hyperparathyroidism hemostasis are conflicting. Thromboelastography helps to evaluate all steps of hemostatic system. Our aim in this study was to investigate the possible role of hemostatic mechanisms in the development of thrombosis in hyperparathyroid patients with the modified rotation thromboelastogram (ROTEM). Materials and methods: Twenty-two patients with primary hyperparathyroidism (PHPT) and 20 healthy controls were involved. This study was conducted in Eskisehir Osmangazi University Faculty of Medicine, Endocrinology …

Short-Term Fasting And Autonomic Control, Joshua Gonzalez

Dissertations, Master's Theses and Master's Reports

Obesity is a chronic metabolic disorder associated with increased risk of cardiovascular disease. Evidence suggests that chronic intermittent fasting improves cardiometabolic health and reduces arterial blood pressure. However, the mechanisms underlying the reductions in blood pressure and improved cardiovascular health observed from chronic fasting studies remain unclear. The autonomic nervous system has a central role in the regulation of blood pressure and is essential for cardiovascular homeostasis. We conducted a study to investigate how acute fasting influences autonomic control of blood pressure at rest and during stress. Twenty-five young, healthy, normal weight, normotensive participants were tested twice, once in the …

Matters Of Biocybersecurity With Consideration To Propaganda Outlets And Biological Agents, Xavier-Lewis Palmer, Ernestine Powell, Lucas Potter, Thaddeus Eze (Ed.), Lee Speakman (Ed.), Cyril Onwubiko (Ed.)

Electrical & Computer Engineering Faculty Publications

The modern era holds vast modalities in human data utilization. Within Biocybersecurity (BCS), categories of biological information, especially medical information transmitted online, can be viewed as pathways to destabilize organizations. Therefore, analysis of how the public, along with medical providers, process such data, and the methods by which false information, particularly propaganda, can be used to upset the flow of verified information to populations of medical professionals, is important for maintenance of public health. Herein, we discuss some interplay of BCS within the scope of propaganda and considerations for navigating the field.

Health & Nutritional Sciences Free Communication Day: Spring 2021 Plan B Abstracts, Brianna Vig, Michael Pappan, Taylor Svehla, Alexander Iverson, Tanner Jerome, Christian Gravius, Kaitlyn Jackman, Savannah Ratermann, Gwyneth Phillips, Jenna Rheder, Erin Hallenbeck, Logan Ammons, Rachel Astleford, Francine Hoffman, Ryan Folley, Kylie Serie, Jenna Christianson, Haley Strait, Kelsey Kessler

Health and Nutritional Sciences Graduate Students Plan B Capstone Projects

This document contains Plan B abstracts presented by graduate students at the Health and Nutritional Sciences Free Communication Day, held on May 4th, 2021.

Abstract titles include:

• Local Restaurants’ Marketing and Sponsorship Within Collegiate Athletics
• Preparing the Future of Campus Recreation
• Motivational Factors Influencing College Choice: NCAA Division I Female Volleyball Athletes
• The Significance of a Successful Internship Program
• Foundations of Publicly Subsidized Sport Stadiums: The Case of U.S. Bank Stadium
• Enhancing Member Experience During a Pandemic
• The Risk of Depression in Football Players Diagnosed with a Concussion
• Effectiveness of Color-Tinted Glasses in Reducing Photophobia in Patients Diagnosed with Mild …

Bacterial Association Networks From Healthy And Cancer-Associated Gut Microbiomes, Mark Loftus

Electronic Theses and Dissertations, 2020-2023

The human gastrointestinal tract is colonized by a diverse community of symbiotic microorganisms, mainly bacteria, that are known to play essential roles in maintaining the health of their human host. Disruption of this bacterial community has been associated with numerous diseases, including Colorectal Cancer (CRC). CRC is one of the leading causes of cancer-related deaths worldwide. As such, focus has been placed on the modulation of the bacterial community within the cancer-associated gut microbiome as the next step in possible CRC treatment and prevention strategies. To use the bacterial community for these purposes, a better understanding of the associations that …

Preparing Student Dental Hygienists In Care Of Persons Of Developmental Disabilities Using A Virtual Patient Module, Janis Mcclelland

EWU Masters Thesis Collection

Purpose: The purpose of the study was to examine if participation in an interactive virtual patient (VP) module increased dental hygiene students’ knowledge in caring for individuals with developmental disability (DD) and if participation in an interactive, VP module would impact dental hygiene students’ perception of difficulty in caring for individuals with DD.

Methods: The study utilized a mixed-methods study design with a convenience sample composed of eighteen (N=18) dental hygiene students. A pre-test/post-test design was utilized in two measures based on the content of the VP module. The eight-item Disability Situations Inventory (DSI) measured perceived sense of difficulty in …

Evaluation Of A ‘Well-Elderly’ Physical Activity Programme, Robert Purcell

Theses

Both in Ireland and internationally people are living longer and there is an increasing proportion of older adults in the population (Clark 2020). As such, the maintenance of health and physical function for older adults is of critical importance. Physical activity is widely acknowledged as being crucial for the maintenance of positive health, particularly for older adults (Spartano et al., 2019). Research has suggested that physical activity programmes are an effective means of engaging older adults in physical activity for the promotion of positive health (Sherrington et al., 2017). The central aim of this research project was to explore the …

Wearable Activity Tracking Device Use In An Adolescent Weight Management Clinic: A Randomized Controlled Pilot Trial, Kanika Bowen-Jallow, Omar Nunez-Lopez, Alex Wright, Erika Fuchs, Mollie Ahn, Elizabeth Lyons, Daniel Jupiter, Lindsey Berry, Oscar Suman, Ravi S Radhakrishnan, Andrea M Glaser, Deborah I Thompson

Children’s Nutrition Research Center Staff Publications

Background: The use of physical activity tracker devices has increased within the general population. However, there is limited medical literature studying the efficacy of such devices in adolescents with obesity. In this study, we explored the feasibility of using wearable activity tracking devices as an adjunct intervention on adolescents with obesity.

Methods: Randomized controlled pilot trial evaluated the feasibility (attrition ≤50%) of an activity tracking intervention (ATI) and its effects on weight loss in adolescents with obesity enrolled in an adolescent weight management clinic (AWMC). Outcomes included feasibility (attrition rate) and absolute change in BMI. Differences between groups at 6, …

Stress Inoculation Training (Sit-Norcal), Part 2: A Pilot Study Among Explosive Ordnance Disposal Special Warfare Enablers, Sarah E Jackson, Matthew R Baity, Patrick R Thomas, Mark Walker, Madeleine Goodkind, Diane Swick, Douglas Barba, Daniel Jacobson, Eric Byrd, A Sarah Ivey

Faculty, Staff and Student Publications

Background: Despite being a well-supported strategy, Stress Inoculation Training (SIT) has not been fully incorporated in the advancement of human performance among most military personnel. The RAND Study recommendations for maximizing SIT's potential within high-risk/ high-intensity occupational groups were used in designing the Core Training protocol targeting psychological performance, SIT-NORCAL (Part 1).

Purpose: The current project (Part 2) sought to further develop the protocol as a health and human performance hybrid through quality improvement analysis of the content, process, and measurement elements for use in the human performance context.

Methods: Evidence-based/evidence-driven methodologies were used in collaborative design tailored to the …