Digital Commons Network^™

Testosterone Acts Through The Membrane Protein Gprc6a To Cause Cardiac Edema In Zebrafish Embryos, Vahid Zadmajid, Shayan Shahriar, Daniel A Gorelick

Faculty, Staff and Students Publications

Androgens are classically thought to act through intracellular androgen receptors (AR/NR3C4), but they can also trigger non-genomic effects via membrane proteins. Although several membrane androgen receptors have been characterized in vitro, their functions in vivo remain unclear. Using a chemical-genetic screen in zebrafish, we found that GPRC6A, a G-protein-coupled receptor, mediates non-genomic androgen actions during embryonic development. Exposure to androgens (androstanedione, DHT and testosterone) caused cardiac edema or tail curvature in wild-type embryos, as well as in ar mutants, suggesting AR-independent pathways. We then mutated putative membrane androgen receptors [gprc6a, hcar1-4 and zip9 (slc39a9)] and found that only gprc6a mutants …

How To Love In Easy Steps: Heteronormativity, Queer Love, And Foucault's Counter-Conduct, Hannah Jane S. Carpiso, Ninotchka Mumtaj B. Albano

Budhi: A Journal of Ideas and Culture

Love is one of the most pervasive human experiences, yet its definition remains elusive to this day. Attempts to describe love have led to the institutionalization and privileging of heterosexual identities, relationships, and ways of loving. Michael Warner refers to this phenomenon as “heteronormativity,” which rigidifies subjectivities and relationalities into fixed, heterosexist structures. However, queer love unfolds in ways different from this relational structure. It invents and re-invents love, relationalities, and subjectivities by moving beyond the dichotomies of heteronormativity. The inventive characteristic of queer love is found in what is known as the “gay mode of life,” an instance of …

Nutrition Recommendations For Patients On Weight Loss Drugs, Crystal M. Duque Rdn-Ldn, Toye Jackman

Department of Nutrition Student Projects

This paper provides a comprehensive, evidence-based framework for dietitians counseling patients who are using GLP-1 receptor agonists, such as Ozempic and Wegovy, for weight management. These medications are rapidly gaining popularity for their effectiveness in supporting weight loss; however, they come with unique nutritional considerations that require tailored guidance. This review outlines key aspects of GLP-1 mechanisms of action, emphasizing how these medications alter digestive processes, specifically impacting the absorption and metabolism of essential macronutrients, including proteins and dietary fibers. The paper also highlights hydration needs to support optimal health and weight loss outcomes in patients on GLP-1 therapies. Additionally, …

Roles Of The Gut Microbiota In Human Neurodevelopment And Adult Brain Disorders, Rahul Mallick, Sanjay Basak, Ranjit Kumar Das, Antara Banerjee, Sujay Paul, Surajit Pathak, Asim K. Duttaroy

Health & Biomedical Sciences Faculty Publications

Growing evidence demonstrates the connection between gut microbiota, neurodevelopment, and adult brain function. Microbial colonization occurs before the maturation of neural systems and its association with brain development. The early microbiome interactions with the gut-brain axis evolved to stimulate cognitive activities. Gut dysbiosis can lead to impaired brain development, growth, and function. Docosahexaenoic acid (DHA) is critically required for brain structure and function, modulates gut microbiota, and impacts brain activity. This review explores how gut microbiota influences early brain development and adult functions, encompassing the modulation of neurotransmitter activity, neuroinflammation, and blood-brain barrier integrity. In addition, it highlights processes of …

The Echo: November 18, 2024, Taylor University

2024-2025 (Volume 112)

No abstract provided.

Mitochondrial Pyruvate Transport Regulates Presynaptic Metabolism And Neurotransmission, Anupama Tiwari, Jongyun Myeong, Arsalan Hashemiaghdam, Marion I Stunault, Hao Zhang, Xiangfeng Niu, Marissa A Laramie, Jasmin Sponagel, Leah P Shriver, Gary J Patti, Vitaly A Klyachko, Ghazaleh Ashrafi

2020-Current year OA Pubs

Glucose has long been considered the primary fuel source for the brain. However, glucose levels fluctuate in the brain during sleep or circuit activity, posing major metabolic stress. Here, we demonstrate that the mammalian brain uses pyruvate as a fuel source, and pyruvate can support neuronal viability in the absence of glucose. Nerve terminals are sites of metabolic vulnerability, and we show that mitochondrial pyruvate uptake is a critical step in oxidative ATP production in hippocampal terminals. We find that the mitochondrial pyruvate carrier is post-translationally modified by lysine acetylation, which, in turn, modulates mitochondrial pyruvate uptake. Our data reveal …

Appendix 1: College Of Medicine Departmental Synoptic Histories, J. G. Reves

MUSC Faculty Bookshelf

This is a multi-contributor compilation of the histories of all the academic departments in the College of Medicine. It was edited by Philippa Newfield, MD, and J.G. Reves, MD. Each department in the College of Medicine has a history and the histories are told primarily by the chairs of the departments.

Investigating The Impact Of Ssris On Cardiovascular Risk Factors In Young Healthy Individuals: A Preliminary Study, Elena S. Shostak, Jillian M. Lang, William Quinn, Valerie Chervinskaya, Elisa Fioraso, Everett Smith, Christopher J. Kotarsky, Justin A. Deblauw, Jennifer Lloyd, Stephen J. Ives

International Journal of Exercise Science: Conference Proceedings

Selective serotonin reuptake inhibitors (SSRIs) are a class of antidepressants that are commonly used to treat anxiety, depression, and other psychological disorders. The effects of SSRIs on cardiometabolic health in young and healthy populations have not been well described. PURPOSE: We evaluated the effects of SSRI useon blood pressure (BP), heart rate variability (HRV), arterial stiffness, and microvascular function, of young, otherwise healthy adults. METHODS: Fourteen healthy males and females aged 18-41 were included in this study, separated by use of SSRIs, and matched into pairs based on sex, age, height, and weight. Anthropometrics, BP, arterial stiffness, HRV, …

Acute Impacts Of A Novel Proprietary Supplement Blend On Aerobically-Focused Outcomes In Trained Crossfit Athletes: A Preliminary Analysis, Ashley Holland, Evan Hedrick, Jason Michael Cholewa, Steven Machek

International Journal of Exercise Science: Conference Proceedings

CrossFit is a high-intensity sport that requires high cardiovascular fitness but aerobically-focused supplements are sparsely investigated within this demographic PURPOSE: to examine the efficacy of a novel ergogenic supplement blend on various cardiovascular metrics in CrossFit athletes. METHODS: 11 trained CrossFit athletes (30±6y; 3M/8F) were recruited for this acute, placebo-controlled study, whereby participants visited the laboratory on a single day to assess baseline resting heart rate (RHR), blood pressure (BP), and fingertip lactate (LAC) immediately prior to being randomly assigned to ingest either 4ml of a proprietary supplement blend (SUP; containing Beetroot, Ashwagandha, Arjuna, Rhodiola, and Cayenne) …

Born High, Born Fast: Does Highland Birth Confer A Pulmonary Advantage For Sea Level Endurance?, Hunter L. Paris, Marissa N. Baranauskas, Keren Constantini, Ren Jay Shei, Peyton E. Allen, John R. Jadovitz, Chad C. Wiggins, Cooker Perkins Storm

All Faculty Open Access Publications

Less than 7% of the world's population live at an altitude above 1500 m. Yet, as many as 67% of medalists in the 2020 men's and women's Olympic marathon, and 100% of medalists in the 2020 men's and women's Olympic 5000 m track race may have been born or raised above this otherwise rare threshold. As a possible explanation, research spanning nearly a quarter of a century demonstrates that indigenous highlanders exhibit pulmonary adaptations distinct from their lowland counterparts. These adaptations may then promote endurance performance. Indeed, healthy indigenous highlanders often exhibit a larger aerobic exercise capacity compared to sea-level …

Artificial Gravity: An Effective Countermeasure For Microgravity-Induced Headward Fluid Shift?, Larry A Kramer, Khader M Hasan, Xu Zhang, Edwin Mulder, Darius A Gerlach, Karina Marshall-Goebel, Brandon R Macias, Steven S Laurie, Gary Strangman, Raj Iyer, Eric M Bershad

Faculty, Staff and Student Publications

Long-duration spaceflight is associated with pathophysiological changes in the intracranial compartment hypothetically linked to microgravity-induced headward fluid shift. This study aimed to determine whether daily artificial gravity (AG) sessions can mitigate these effects, supporting its application as a countermeasure to spaceflight. Twenty-four healthy adult volunteers (16 men) were exposed to 60 days of 6° head-down tilt bed rest (HDTBR) as a ground-based analog of chronic headward fluid shift. Subjects were divided equally into three groups: no AG (control), daily 30-min intermittent AG (iAG), and daily 30-min continuous (cAG). Internal carotid artery (ICA) stroke volume (ICASV), ICA resistive index (ICARI), ICA …

Therapeutic Targeting Of Hypoxia Inducible Factor In Acute Respiratory Distress Syndrome, Thu T Tran, Holger K Eltzschig, Xiaoyi Yuan

Faculty, Staff and Student Publications

Acute respiratory distress syndrome (ARDS) is characterized by bilateral chest infiltration and acute hypoxic respiratory failure. ARDS carries significant morbidity and mortality despite advancements in medical management, calling for the development of novel therapeutic targets. Hypoxia-inducible factor (HIF) is a heterodimeric protein involved in various essential pathways, including metabolic reprogramming, immune modulation, angiogenesis and cell cycle regulation. HIF is routinely degraded in homeostasis conditions via the prolyl hydroxylase domain/von Hippel-Lindau protein pathway. However, HIF is stabilized in ARDS via various mechanisms (oxygen-dependent and independent) as an endogenous protective pathway and plays multifaceted roles in different cell populations. This review focuses …

Stressfit: A Hybrid Wearable Physicochemical Sensor Suite For Simultaneously Measuring Electromyogram And Sweat Cortisol, Nafize Ishtiaque Hossain, Tanzila Noushin, Shawana Tabassum

Electrical Engineering Faculty Publications and Presentations

This study introduces StressFit, a novel hybrid wearable sensor system designed to simultaneously monitor electromyogram (EMG) signals and sweat cortisol levels. Our approach involves the development of a noninvasive skin patch capable of monitoring skin temperature, sweat pH, cortisol levels, and corresponding EMG signals using a combination of physical and electrochemical sensors integrated with EMG electrodes. StressFit was optimized by enhancing sensor output and mechanical resilience for practical application on curved body surfaces, ensuring accurate acquisition of cortisol, pH, body temperature, and EMG data without sensor interference. In addition, we integrated an onboard data processing unit with Internet of Things …

University Of Dayton Roadmap To The Mcat: Tracking Mcat Content In Your Natural And Behavioral Science Courses, University Of Dayton

Pre-Health Resource Center Campus Communications

No abstract provided.

Evaluating Uv-Protective Low-Emissivity Window Films: Implications For Thermal And Visual Comfort In Luminous Office Buildings, Lina M. Shaker

AUIQ Complementary Biological System

This review article explores the integration of thin window films and solar energy systems to enhance thermal comfort in luminous office buildings. Luminous office buildings, which prioritize natural lighting, often face challenges in maintaining thermal comfort for occupants. By integrating solar energy systems, such as photovoltaic (PV) and solar thermal systems, with thin window films, it is possible to optimize thermal comfort while harnessing sustainable energy sources. Thin window films act as a barrier against solar radiation, reducing heat gain while allowing therapeutic blue light (400-520nm) transmission. The advantages of thin window films include improved thermal insulation, glare reduction, and …

The Function Of P97/Valosin-Containing Protein (Vcp) And Small Vcp-Interacting Protein (Svip) In Invasion And Migration Of Pancreatic Cancer Cells, Ebru Ali̇moğullari, Sevi̇l Çayli

Turkish Journal of Medical Sciences

Background/aim: Misfolded proteins are eliminated by a process known as Endoplasmic reticulum-associated protein degradation (ERAD). ERAD has an impact on variety of illnesses, such as diabetes, cystic fibrosis, cancer, and neurological conditions. We concentrated on p97/Valosin-containing protein (VCP) and small VCP-interacting protein (SVIP) despite there being many proteins involved in ERAD. The existence and function of SVIP and p97/VCP in various types of pancreatic cancer have not yet been investigated. The study's objectives are to examine the expressions of SVIP and p97/VCP in two pancreatic cancer types and to show whether these proteins aid in the invasion and migration of …

Cover And Front Matter

Research and Reflection on Learning and Teaching in Higher Education

No abstract provided.

Undergraduate And Graduate Course Descriptions, Fall 2024, Wright State University

Course Descriptions

Wright State University undergraduate and graduate course descriptions from Fall 2024

Ophidiomyces Ophidiicola And Texas Snakes: A Field To Bench Study Of Ophidiomycosis, Kenlynn L. Volz

Biology Theses

Ophidiomyces ophidiicola (Oo), the primary cause of Ophidiomycosis, is a fungal pathogen recently detected in Texas snakes. Prior to this study, there were major knowledge gaps regarding Oo growth, spread, and suitable environmental conditions. This study filled those gaps using a field to bench approach involving sampling snakes across Texas, in vitro fungal growth, and ecological niche modeling. 103 snakes were sampled across Texas in 2023 and 2024 and six cases of Oo infection were detected. Results of the growth experiment suggest that Oo prefers more stable temperatures and high humidity to a point and that there is a …

On The Pathogenesis Of Obesity: Causal Models And Missing Pieces Of The Puzzle, Faidon Magkos, Thorkild I.A. Sørensen, David Raubenheimer, Nikhil V. Dhurandhar, Ruth J.F. Loos, Anja Bosy-Westphal, Christoffer Clemmensen, Mads F. Hjorth, David B. Allison, Gary Taubes, Eric Ravussin, Mark I. Friedman, Kevin D. Hall, David S. Ludwig, John R. Speakman, Arne Astrup

Clinical Research Faculty Publications

Application of the physical laws of energy and mass conservation at the whole-body level is not necessarily informative about causal mechanisms of weight gain and the development of obesity. The energy balance model (EBM) and the carbohydrate–insulin model (CIM) are two plausible theories, among several others, attempting to explain why obesity develops within an overall common physiological framework of regulation of human energy metabolism. These models have been used to explain the pathogenesis of obesity in individuals as well as the dramatic increases in the prevalence of obesity worldwide over the past half century. Here, we summarize outcomes of a …

Silver Linings 2024, Tower Health

Silver Linings

No abstract provided.

Emeriti News Fall 2024, Emeriti Council

Emeriti News

• Message from the Chair:
• Information about the Emeriti Council
• Wednesday II Events
• University News
• Faculty Senate Updates
• Student Scholarships
• In Memory

Opportunities For Helicobacter Pylori Eradication Beyond Conventional Antibiotics, Camilia Metadea Aji Savitri, Kartika Afrida Fauzia, Ricky Indra Alfaray, Hafeza Aftab, Ari Fahrial Syam, Masrul Lubis, Yoshio Yamaoka, Muhammad Miftahussurur

Faculty, Staff and Students Publications

Helicobacter pylori (H. pylori) is a bacterium known to be associated with a significant risk of gastric cancer in addition to chronic gastritis, peptic ulcer, and MALT lymphoma. Although only a small percentage of patients infected with H. pylori develop gastric cancer, Gastric cancer causes more than 750,000 deaths worldwide, with 90% of cases being caused by H. pylori. The eradication of this bacterium rests on multiple drug regimens as guided by various consensus. However, the efficacy of empirical therapy is decreasing due to antimicrobial resistance. In addition, biofilm formation complicates eradication. As the search for new antibiotics …

Effect Of Citrus Sinensis And Musa Textilia Consumption On Lactic Acid Levels And Muscle Tension In Fish Auction Workers, Bina Kurniawan, Mohammad Zen Rahfiludin, Yuliani Setyaningsih, Nurjazuli Nurjazuli

Media Kesehatan Masyarakat Indonesia

Potassium deficiency is known to induce muscle fatigue, necessitating the inclusion of potassium-rich foods, such as orange (Citrus sinensis) and banana (Musa textilia) in diet. Previous studies have shown that consuming 150 g and 300 g of banana is effective in preventing muscle fatigue, with orange containing 237.4 mg of potassium per 300 ml. Therefore, this study aims to examine the relationship between lactic acid concentration and muscle tension reduction in fish auction workers after the administration of orange and banana. The study procedures were carried out with a quasi-experimental pre-test and post-test group design, and …

Germline Mutations In A G Protein Identify Signaling Cross-Talk In T Cells, Hyoungjun Ham, Huie Jing, Ian T Lamborn, Megan M Kober, Alexey Koval, Yamina A Berchiche, D Eric Anderson, Kirk M Druey, Judith N Mandl, Bertrand Isidor, Carlos R Ferreira, Alexandra F Freeman, Sundar Ganesan, Meliha Karsak, Peter J Mustillo, Juliana Teo, Zarazuela Zolkipli-Cunningham, Nicolas Chatron, François Lecoquierre, Andrew J Oler, Jana Pachlopnik Schmid, Douglas B Kuhns, Xuehua Xu, Fabian Hauck, Waleed Al-Herz, Matias Wagner, Paulien A Terhal, Mari Muurinen, Vincent Barlogis, Phillip Cruz, Jeffrey Danielson, Helen Stewart, Petra Loid, Sebastian Rading, Boris Keren, Rolph Pfundt, Kol A Zarember, Katharina Vill, Lorraine Potocki, Kenneth N Olivier, Gaetan Lesca, Laurence Faivre, Melanie Wong, Anne Puel, Janet Chou, Maud Tusseau, Niki M Moutsopoulos, Helen F Matthews, Cas Simons, Ryan J Taft, Ariane Soldatos, Etienne Masle-Farquhar, Stefania Pittaluga, Robert Brink, Danielle L Fink, Heidi H Kong, Juraj Kabat, Woo Sung Kim, Tatjana Bierhals, Kazuyuki Meguro, Amy P Hsu, Jingwen Gu, Jennifer Stoddard, Benito Banos-Pinero, Maria Slack, Giampaolo Trivellin, Benoît Mazel, Maarja Soomann, Samuel Li, Val J Watts, Constantine A Stratakis, Maria F Rodriguez-Quevedo, Ange-Line Bruel, Marita Lipsanen-Nyman, Paul Saultier, Rashmi Jain, Daphne Lehalle, Daniel Torres, Kathleen E Sullivan, Sébastien Barbarot, Axel Neu, Yannis Duffourd, Morgan Similuk, Kirsty Mcwalter, Pierre Blanc, Stéphane Bézieau, Tian Jin, Raif S Geha, Jean-Laurent Casanova, Outi M Makitie, Christian Kubisch, Patrick Edery, John Christodoulou, Ronald N Germain, Christopher C Goodnow, Thomas P Sakmar, Daniel D Billadeau, Sébastien Küry, Vladimir L Katanaev, Yu Zhang, Michael J Lenardo, Helen C Su

Center for Medical Ethics and Health Policy Staff Publications

Humans with monogenic inborn errors responsible for extreme disease phenotypes can reveal essential physiological pathways. We investigated germline mutations in GNAI2, which encodes Gαi2, a key component in heterotrimeric G-protein signal transduction usually thought to regulate adenylyl cyclase-mediated cAMP production. Patients with activating Gαi2 mutations had clinical presentations that included impaired immunity. Mutant Gαi2 impaired cell migration and augmented responses to T cell receptor (TCR) stimulation. We found that mutant Gαi2 influenced TCR signaling by sequestering the GTPase-activating protein RASA2, thereby promoting RAS activation and increasing downstream ERK/MAPK and PI3K-AKT S6 signaling to drive cellular growth and proliferation.

Interprofessional Education To Support Alcohol Use Screening And Future Team-Based Management Of Stress-Related Disorders In Vulnerable Populations, Taylor Fitzpatrick-Schmidt, Scott Edwards

School of Graduate Studies Faculty Publications

Introduction: Alcohol use disorder (AUD) is a psychiatric disease that affects approximately 10% of the population. Individuals suffer from a myriad of causes and consequences of AUD, and team-based management of patients is often required for given the chronic and complex nature of the disease. Interprofessional education (IPE) for biomedical science and health professional students that incorporates patient-centered cases focused on AUD and adjacent stress-related disorders may improve future collaboration in managing these conditions and community outcomes related to wellbeing. Methods: This study assessed the impact of a single, 90-minute IPE exercise on improving confidence in possessing the knowledge and …

Advancing Emotional Health Assessments: A Hybrid Deep Learning Approach Using Physiological Signals For Robust Emotion Recognition, Amna Waheed Awan, Imran Taj, Shehzad Khalid, Syed Muhammad Usman, Ali Shariq Imran, Muhammad Usman Akram

All Works

Emotional health significantly impacts physical and psychological well-being, with emotional imbalances and cognitive disorders leading to various health issues. Timely diagnosis of mental illnesses is crucial for preventing severe disorders and enhancing medical care quality. Physiological signals, such as Electrocardiograms (ECG) and Electroencephalograms (EEG), which reflect cardiac and neuronal activities, are reliable for emotion recognition as they are less susceptible to manipulation than physical signals. Galvanic Skin Response (GSR) is also closely linked to emotional states. Researchers have developed various methods for classifying signals to detect emotions. However, these signals are susceptible to noise and are inherently non-stationary, meaning they …

Curricular Changes Proposed For 2025-2027 Morris Catalog Division Of Science And Mathematics, Program Changes, And Morris Core Curriculum, Curriculum Committee

Curriculum Committee Reports

No abstract provided.

Wmdds Bulletin Winter 2020

West Michigan District Dental Society Bulletin

In the Winter 2020 issue, the reader will find the following feature articles:

• 2020 Silent Bell Recipient: W. Erick Rupprecht, DDS
• Dentists Beyond the Chair: Aquarist and Fish Breeder – Chase Klinesteker, DDS

Also included are your monthly tripartite update, news from West Michigan counties, the President's Message and Editor's Letter.

2024 September 13 - Board Of Trustees Academic, Research, And Student Success Committee Agenda And Minutes, Board Of Trustees, East Tennessee State University

Board of Trustees Agendas and Minutes

No abstract provided.