Digital Commons Network^™

Body Composition And Performance Associations With Common Carotid Artery Hemodynamics And Stiffness Indices In Males And Females, Lavleen Sandhu, Zaria Opara, Michael Diaz, Gabriel Hernandez, Octavia Gosnell, Louise Kelly Phd, Allan Knox Phd, Jie Liu Phd

International Journal of Exercise Science: Conference Proceedings

Sex differences in physiological parameters are being increasingly recognized as a robust prognostic factor in individuals at risk or suffering from cardiovascular disease. Body composition and physical performance measures of cardiorespiratory fitness and muscular strength are strongly associated with overall vascular health. PURPOSE: This study aimed to determine if body composition and physical performance measures were related to common carotid artery (CCA) hemodynamics and stiffness in males and females. METHODS: College-aged males and females who were free from cardiovascular risk factors performed a maximal oxygen consumption test (VO_2max) via indirect calorimetry and a maximal leg strength …

Common Carotid Artery Hemodynamic And Stiffness Responses To Acute And Repeated Bouts Of High Intensity Cardiorespiratory And Resistance Exercise, Zaria S. Opara, Michael Diaz, Lavleen Sandhu, Gabriel Hernandez, Octavia Gosnel, Louise Kelly Ph.D, Jie Liu Md, Ph.D, Allan Knox Ph.D

International Journal of Exercise Science: Conference Proceedings

High intensity exercise is a popular mode of physical activity amongst professional and recreational athletes. The physiological stress induced by intense cardiorespiratory and muscular strengthening exercise has clinically relevant cardiovascular benefits. However, the immediate cerebrovascular response to acute and repeated bouts of intense exercise has yet to be determined. PURPOSE: To observe the hemodynamic and stiffness indexes of the common carotid artery (CCA) in response to acute and repeated bouts of cardiorespiratory and resistance exercise. METHODS: Participants (n=28) performed a maximal oxygen consumption test (VO_2max), leg strength test (1RM), a sprint interval session (SIS, all out …

Peripheral And Cerebral Arterial Hemodynamic And Mechanical Responses To A Maximal Oxygen Consumption Exercise Test In Males And Females, Octavia Gosnell, Zaria Opara, Michael Diaz, Lavleen Sandhu, Gabriel Hernandez, Louise Kelly, Jie Liu, Allan Knox

International Journal of Exercise Science: Conference Proceedings

Variations in physiological responses to exercise between males and females have been identified by previous investigations. Maximal oxygen consumption tests (VO_2max) are widely used for exercise prescription within the professional and recreational capacity, in addition to providing insight of overall cardiovascular and pulmonary health. However, the specific response of multiple components of the arterial network have yet to be established and compared within males and females. PURPOSE: To determine the hemodynamic and mechanical responses of the brachial artery (BA), the common carotid artery (CCA), and the internal carotid artery (ICA) to VO_2max. METHODS: College-aged …

The Effect Of Covid- 19 Pandemic Process On Social Psychology And Nature-Based Therapeutic Activities, Aysun Yalvac, Esmahan Yalcin, Murad A. Kasalak

University of South Florida (USF) M3 Publishing

Today, many scientists have stated that the use of nature-based products and activities at certain rates together with the healing effect of modern medical techniques during the epidemic that affects the whole world has health-supporting benefits. Based on these views, people's consumption of products obtained from natural resources has increased and the interest in outdoor activities in nature has increased. Due to the positive effects of these activities on mental health, socialization and rehabilitation processes, over time, it became necessary to consider these activities within the scope of therapeutic recreation applied to groups with health restrictions such as the disabled, …

The Effects Of Acute High-Intensity Interval Exercise And Hyperinsulinemic-Euglycemic Clamp On Osteoglycin Levels In Young And Middle-Aged Men, Carlie Bauer, Alexander Tacey, Andrew Garnham, Cassandra Smith, Mary N. Woessner, Xuzhu Lin, Navabeh Zarekookandeh, David L. Hare, Joshua R. Lewis, Lewan Parker, Itamar Levinger

Research outputs 2022 to 2026

Osteoglycin (OGN) is a leucine-rich proteoglycan that has been implicated in the regulation of glucose in animal models. However, its relationship with glucose control in humans is unclear. We examined the effect of high-intensity interval exercise (HIIE) and hyperinsulinemic-euglycemic clamp on circulating levels of OGN as well as whether circulating OGN levels are associated with markers of glycemic control and cardio-metabolic health. Serum was analyzed for OGN (ELISA) levels from 9 middle-aged obese men (58.1 ± 2.2 years, body mass index [BMI] = 33.1 ± 1.4 kg∙m ^{− 2}, mean ± SEM) and 9 young men (27.8 ± 1.6 …

Exploring Physiology Instructors’ Use Of Core Concepts: Pedagogical Factors That Influence Choice Of Course Topics, Jeremy L. Hsu, Patricia A. Halpin

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

The physiology core concepts are designed to guide instructors in undergraduate physiology courses. However, although past work has characterized the alignment of physiology programs with the core concepts, it is unclear to what extent these core concepts have influenced instructors’ pedagogical decisions or how represented these core concepts are across physiology courses. We surveyed undergraduate physiology instructors to determine their familiarity with the core concepts, the impact of the core concepts on their teaching, as well as the alignment of their courses with these core concepts. Instructors report predominantly relying on textbooks and past syllabi of their courses as resources …

Quantifying Crossfit®: Potential Solutions For Monitoring Multimodal Workloads And Identifying Training Targets, Gerald T. Mangine, Tucker R. Seay

Open Access Publishing Fund Collection

The design of high-intensity functional training (HIFT; e. g., CrossFit^®) workouts and targeted physiological trait(s) vary on any given training day, week, or cycle. Daily workouts are typically comprised of different modality and exercise combinations that are prescribed across a wide range of intensities and durations. The only consistent aspect appears to be the common instruction to maximize effort and workout density by either completing “as many repetitions as possible” within a time limit (e.g., AMRAP, Tabata) or a list of exercises as quickly as possible. However, because effort can vary within and across workouts, the impact on …

Chronic Stress May Disrupt Covariant Fluctuations Of Vitamin D And Cortisol Plasma Levels And Placentome Formation In Pregnant Sheep During The Last Trimester: A Methodological Approach And Preliminary Report, Colin Wakefield

Tower Health Research Day

No abstract provided.

Lactate/Albumin Ratio As A Predictor Of Mortality In Patients With Sepsis And Septic Shock: A Meta-Analysis Study, Fahri Ahmad Baihaqi, Dinda Olinda Delarosa, Rezki Ramadhan

Jurnal Penyakit Dalam Indonesia

Introduction. The lactate/albumin ratio is an inflammatory biomarker that has been widely used and suggested as a predictor of mortality in patients with sepsis and septic shock. However, the results are inconsistent. This meta-analysis aimed to evaluate the prognostic value of lactate/albumin ratio as a predictor of mortality in patients with sepsis and septic shock.Methods. The study protocol was registered with PROSPERO (CRD42021286242). A literature search was performed using PubMed, Ovid EMBASE, Ovid MEDLINE, SCOPUS, and Web of Sciences to find all studies evaluating the association between lactate/albumin ratio and mortality in patients with sepsis and septic shock. Meta-analysis was …

Amino Acids, Microbiota-Related Metabolites, And The Risk Of Incident Diabetes Among Normoglycemic Chinese Adults: Findings From The 4c Study, Shuangyuan Wang, Mian Li, Hong Lin, Guixia Wang, Yu Xu, Xinjie Zhao, Chunyan Hu, Yi Zhang, Ruizhi Zheng, Ruying Hu, Lixin Shi, Rui Du, Qing Su, Jiqiu Wang, Yuhong Chen, Xuefeng Yu, Li Yan, Tiange Wang, Zhiyun Zhao, Ruixin Liu, Xiaolin Wang, Qi Li, Guijun Qin, Qin Wan, Gang Chen, Min Xu, Meng Dai, Di Zhang, Xulei Tang, Zhengnan Gao, Feixia Shen, Zuojie Luo, Yingfen Qin, Li Chen, Yanan Huo, Qiang Li, Zhen Ye, Yinfei Zhang, Chao Liu, Youmin Wang, Shengli Wu, Tao Yang, Huacong Deng, Jiajun Zhao, Shenghan Lai, Yiming Mu, Lulu Chen, Donghui Li, Guowang Xu, Guang Ning, Weiqing Wang, Yufang Bi, Jieli Lu

Faculty, Staff and Student Publications

Although previous studies suggest that amino acids (AAs) and microbiota-related metabolites (MRMs) are associated with type 2 diabetes mellitus (T2DM), the results remain unclear among normoglycemic populations. We test 28 serum AAs and 22 MRMs in 3,414 subjects with incident diabetes and matched normoglycemic controls from the China Cardiometabolic Disease and Cancer Cohort (4C) Study. In fully adjusted logistic regression models, per SD increment of branched-chain AAs, aromatic AAs, asparagine, alanine, glutamic acid, homoserine, 2-aminoadipic acid, histidine, methionine, and proline are positively associated with incident T2DM. In the MRM panel, serum carnitines, N-acetyltryptophan, and uric acid are positively associated with …

Serpinb3 Drives Cancer Stem Cell Survival In Glioblastoma, Adam Lauko, Josephine Volovetz, Soumya M Turaga, Defne Bayik, Daniel J Silver, Kelly Mitchell, Erin E Mulkearns-Hubert, Dionysios C Watson, Kiran Desai, Manav Midha, Jing Hao, Kathleen Mccortney, Alicia Steffens, Ulhas Naik, Manmeet S Ahluwalia, Shideng Bao, Craig Horbinski, Jennifer S Yu, Justin D Lathia

Department of Medicine Faculty Papers

Despite therapeutic interventions for glioblastoma (GBM), cancer stem cells (CSCs) drive recurrence. The precise mechanisms underlying CSC resistance, namely inhibition of cell death, are unclear. We built on previous observations that the high cell surface expression of junctional adhesion molecule-A drives CSC maintenance and identified downstream signaling networks, including the cysteine protease inhibitor SerpinB3. Using genetic depletion approaches, we found that SerpinB3 is necessary for CSC maintenance, survival, and tumor growth, as well as CSC pathway activation. Knockdown of SerpinB3 also increased apoptosis and susceptibility to radiation therapy. SerpinB3 was essential to buffer cathepsin L-mediated cell death, which was enhanced …

Promoting Validation And Cross-Phylogenetic Integration In Model Organism Research., Keith C Cheng, Rebecca D Burdine, Mary E Dickinson, Stephen C Ekker, Alex Y Lin, K C Kent Lloyd, Cathleen Lutz, Calum A Macrae, John H Morrison, David H O'Connor, John H Postlethwait, Crystal D Rogers, Susan Sanchez, Julie H Simpson, William S Talbot, Douglas C Wallace, Jill M Weimer, Hugo J Bellen

Faculty Research 2022

Model organism (MO) research provides a basic understanding of biology and disease due to the evolutionary conservation of the molecular and cellular language of life. MOs have been used to identify and understand the function of orthologous genes, proteins, cells and tissues involved in biological processes, to develop and evaluate techniques and methods, and to perform whole-organism-based chemical screens to test drug efficacy and toxicity. However, a growing richness of datasets and the rising power of computation raise an important question: How do we maximize the value of MOs? In-depth discussions in over 50 virtual presentations organized by the National …

Risk Of Type 2 Diabetes Among Individuals With Excess Weight: Weight Trajectory Effects, Arthur H Owora, David B Allison, Xuan Zhang, Nana Gletsu-Miller, Kishore M Gadde

Children’s Nutrition Research Center Staff Publications

PURPOSE OF REVIEW: Increased risk of type 2 diabetes mellitus (T2D) among individuals with overweight or obesity is well-established; however, questions remain about the temporal dynamics of weight change (gain or loss) on the natural course of T2D in this at-risk population. Existing epidemiologic evidence is limited to studies that discretely sample and assess excess weight and T2D risk at different ages with limited follow-up, yet changes in weight may have time-varying and possibly non-linear effects on T2D risk. Predicting the impact of weight change on the risk of T2D is key to informing primary prevention. We critically review the …

Comorbidity Of Novel Crhr2 Gene Variants In Type 2 Diabetes And Depression, Mutaz Amin, Jurg Ott, Derek Gordon, Rongling Wu, Teodor T Postolache, Michael Vergare, Claudia Gragnoli

Department of Psychiatry and Human Behavior Faculty Papers

The corticotropin-releasing hormone receptor 2 (CRHR2) gene encodes CRHR2, contributing to the hypothalamic-pituitary-adrenal stress response and to hyperglycemia and insulin resistance. CRHR2-/- mice are hypersensitive to stress, and the CRHR2 locus has been linked to type 2 diabetes and depression. While CRHR2 variants confer risk for mood disorders, MDD, and type 2 diabetes, they have not been investigated in familial T2D and MDD. In 212 Italian families with type 2 diabetes and depression, we tested 17 CRHR2 single nucleotide polymorphisms (SNPs), using two-point parametric-linkage and linkage-disequilibrium (i.e., association) analysis (models: dominant-complete-penetrance-D1, dominant-incomplete-penetrance-D2, recessive-complete-penetrance-R1, recessive-incomplete-penetrance-R2). We detected novel linkage/linkage-disequilibrium/association …

Modelling Neurological Diseases In Large Animals: Criteria For Model Selection And Clinical Assessment, Samantha L Eaton, Jonathan D Cooper, Et Al.

2020-Current year OA Pubs

No abstract provided.

Evaluation Of Ecg Repolarization Parameters In A Worker Cohort Working The Night Shift, Sezen Baglan Uzunget, Kader Eliz Sahin

Journal of the Saudi Heart Association

Objectives: Night Shift work is an increasingly common working order that affects human well-being and it is little known about its arrhythmic role in the cardiovascular system. We aimed to investigate the effect of working at night shifts on P-wave dispersion (Pd), QT and QTc dispersions (QTd, QTcd resp) on surface electrocardiography. Methods: We included 286 foundry workers who work at night shift and 100 foundry workers who work on day time only. The night shift workers were divided into three subgroups according to the length of time they worked at night shift. Surface electrocardiography and blood tests were applied …

Human Total, Basal And Activity Energy Expenditures Are Independent Of Ambient Environmental Temperature, Xueying Zhang, Yosuke Yamada, Hiroyuki Sagayama, Philip N Ainslie, Ellen E Blaak, Maciej S Buchowski, Graeme L Close, Jamie A Cooper, Sai Krupa Das, Lara R Dugas, Michael Gurven, Asmaa El Hamdouchi, Sumei Hu, Noorjehan Joonas, Peter Katzmarzyk, William E Kraus, Robert F Kushner, William R Leonard, Corby K Martin, Erwin P Meijer, Marian L Neuhouser, Robert M Ojiambo, Yannis P Pitsiladis, Guy Plasqui, Ross L Prentice, Susan B Racette, Eric Ravussin, Leanne M Redman, Rebecca M Reynolds, Susan B Roberts, Luis B Sardinha, Analiza M Silva, Eric Stice, Samuel S Urlacher, Edgar A Van Mil, Brian M Wood, Alexia J Murphy-Alford, Cornelia Loechl, Amy H Luke, Jennifer Rood, Dale A Schoeller, Klaas R Westerterp, William W Wong, Herman Pontzer, John R Speakman, Iaea Dlw Database Consortium

Children’s Nutrition Research Center Staff Publications

Lower ambient temperature (Ta) requires greater energy expenditure to sustain body temperature. However, effects of Ta on human energetics may be buffered by environmental modification and behavioral compensation. We used the IAEA DLW database for adults in the USA (n = 3213) to determine the effect of Ta (−10 to +30°C) on TEE, basal (BEE) and activity energy expenditure (AEE) and physical activity level (PAL). There were no significant relationships (p > 0.05) between maximum, minimum and average Ta and TEE, BEE, AEE and PAL. After adjustment for fat-free mass, fat mass and age, statistically significant (p < 0.01) relationships between TEE, BEE and Ta emerged in females but the effect sizes were not biologically meaningful. Temperatures inside buildings are regulated at 18–25°C independent of latitude. Hence, adults in the US modify their environments to keep TEE constant across a wide range of external ambient temperatures.

The Health Effects Of A Plant-Based Diet On The Human Gut Microbiome, Bryant T. Bell

Student Papers, Posters & Projects

The popularity of a plant-based diet is sweeping the western world. Markets and social media influencers are promoting and encouraging this dietary lifestyle. With people switching diets, research is needed to see how one’s gut microbiome and health are affected. In this review article, the health effect of a plant-based diet on the gut microbiota is evaluate. Over 15 articles contained research on the physiology of the gastrointestinal system, microbes in the gut, nutrition, and diets affecting health issues. It is concluded that a plant-based diet promotes good health and gut microbiome; however, there are some nutritional deficiencies that may …

Antithrombin-Iii Mitigates Thrombin-Mediated Endothelial Cell Contraction And Sickle Red Blood Cell Adhesion In Microscale Flow, William J. Wulftange, Erdem Kucukal, Yuncheng Man, Ran An, Karamoja Monchamp, Charlotte D. Sevrain, Himanshu R. Dashora, Allison Bode, Jane A. Little, Umut A. Gurkan

Faculty Scholarship

Individuals with sickle cell disease (SCD) have persistently elevated thrombin generation that results in a state of systemic hypercoagulability. Antithrombin-III (ATIII), an endogenous serine protease inhibitor, inhibits several enzymes in the coagulation cascade, including thrombin. Here, we utilize a biomimetic microfluidic device to model the morphology and adhesive properties of endothelial cells (ECs) activated by thrombin and examine the efficacy of ATIII in mitigating the adhesion of SCD patient-derived red blood cells (RBCs) and EC retraction. Microfluidic devices were fabricated, seeded with ECs, and incubated under physiological shear stress. Cells were then activated with thrombin with or without an ATIII …

Association Of Rare Apoe Missense Variants V236e And R251g With Risk Of Alzheimer Disease, Yann Le Guen, Michael E Belloy, Benjamin Grenier-Boley, Itziar De Rojas, Atahualpa Castillo-Morales, Iris Jansen, Aude Nicolas, Céline Bellenguez, Carolina Dalmasso, Fahri Küçükali, Sarah J Eger, Katrine Laura Rasmussen, Jesper Qvist Thomassen, Jean-François Deleuze, Zihuai He, Valerio Napolioni, Philippe Amouyel, Frank Jessen, Patrick G Kehoe, Cornelia Van Duijn, Magda Tsolaki, Pascual Sánchez-Juan, Kristel Sleegers, Martin Ingelsson, Giacomina Rossi, Mikko Hiltunen, Rebecca Sims, Wiesje M Van Der Flier, Alfredo Ramirez, Ole A Andreassen, Ruth Frikke-Schmidt, Julie Williams, Agustín Ruiz, Jean-Charles Lambert, Michael D Greicius, Members Of The Eadb, Gr@Ace, Degesco, Demgene, Gerad, And Eadi Groups, Beatrice Arosio, Luisa Benussi, Anne Boland, Barbara Borroni, Paolo Caffarra, Delphine Daian, Antonio Daniele, Stéphanie Debette, Carole Dufouil, Emrah Düzel, Daniela Galimberti, Vilmantas Giedraitis, Timo Grimmer, Caroline Graff, Edna Grünblatt, Olivier Hanon, Lucrezia Hausner, Stefanie Heilmann-Heimbach, Henne Holstege, Jakub Hort, Deckert Jürgen, Teemu Kuulasmaa, Aad Van Der Lugt, Carlo Masullo, Patrizia Mecocci, Shima Mehrabian, Alexandre De Mendonça, Susanne Moebus, Benedetta Nacmias, Gael Nicolas, Robert Olaso, Goran Papenberg, Lucilla Parnetti, Florence Pasquier, Oliver Peters, Yolande A L Pijnenburg, Julius Popp, Innocenzo Rainero, Inez Ramakers, Steffi Riedel-Heller, Nikolaos Scarmeas, Philip Scheltens, Norbert Scherbaum, Anja Schneider, Davide Seripa, Hilkka Soininen, Vincenzo Solfrizzi, Gianfranco Spalletta, Alessio Squassina, John Van Swieten, Thomas J Tegos, Lucio Tremolizzo, Frans Verhey, Martin Vyhnalek, Jens Wiltfang, Mercè Boada, Pablo García-González, Raquel Puerta, Luis M Real, Victoria Álvarez, María J Bullido, Jordi Clarimon, José María García-Alberca, Pablo Mir, Fermin Moreno, Pau Pastor, Gerard Piñol-Ripoll, Laura Molina-Porcel, Jordi Pérez-Tur, Eloy Rodríguez-Rodríguez, Jose Luís Royo, Raquel Sánchez-Valle, Martin Dichgans, Dan Rujescu

Faculty, Staff and Students Publications

IMPORTANCE: The APOE ε2 and APOE ε4 alleles are the strongest protective and risk-increasing, respectively, genetic variants for late-onset Alzheimer disease (AD). However, the mechanisms linking APOE to AD-particularly the apoE protein's role in AD pathogenesis and how this is affected by APOE variants-remain poorly understood. Identifying missense variants in addition to APOE ε2 and APOE ε4 could provide critical new insights, but given the low frequency of additional missense variants, AD genetic cohorts have previously been too small to interrogate this question robustly.

OBJECTIVE: To determine whether rare missense variants on APOE are associated with AD risk.

DESIGN, SETTING, …

Sars-Cov-2 Neuroinvasion, Inflammatory Neurodegeneration And Alzheimer's Disease, Yuhai Zhao, Walter J. Lukiw

School of Medicine Faculty Publications

No abstract provided.

Microrna, The Innate-Immune System And Sars-Cov-2, James M. Hill, Walter J. Lukiw

School of Medicine Faculty Publications

The single-stranded viral RNA (ssvRNA) known as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes COVID-19 can be effectively inactivated by a number of natural ribonucleic acid-based host cell defenses. One of the most important of these defenses includes the actions of a class of small non-coding RNAs (sncRNAs) known as microRNAs (miRNAs). Via base-pair complementarity miRNAs are capable of specifically targeting ssvRNA sequences such as SARS-CoV-2 promoting its inactivation and neutralization. RNA-sequencing and bioinformatics analysis indicate that multiple naturally-occurring human miRNAs have extensive complementarity to the SARS-CoV-2 ssvRNA genome. Since miRNA abundance, speciation, and complexity vary significantly …

Gut Dysbiosis And Age-Related Neurological Diseases In Females, Janelle M Korf, Bhanu P Ganesh, Louise D Mccullough

Faculty, Staff and Student Publications

Historically, females have been underrepresented in biological research. With increased interest in the gut microbiome and the gut-brain axis, it is important for researchers to pursue studies that consider sex as a biological variable. The composition of the gut microbiome is influenced by environmental factors, disease, diet, and varies with age and by sex. Detrimental changes in the gut microbiome, referred to as dysbiosis, is believed to influence the development and progression of age-related neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and stroke. Many are investigating the changes in microbial populations in order or to better understand …

French-Fried Potato Consumption And Energy Balance: A Randomized Controlled Trial, Daniel L Smith, Rebecca L Hanson, Stephanie L Dickinson, Xiwei Chen, Amy M Goss, John B Cleek, W Timothy Garvey, David B Allison

Children’s Nutrition Research Center Staff Publications

Background: Epidemiologic observations suggest increased potato consumption correlates with weight gain, adiposity, and diabetes risk, whereas nut consumption is associated with weight control and metabolic health. Randomized controlled trial (RCT) data indicate humans respond to changes in energy intake in single dietary components and compensate for extra energy consumed.

Objectives: We completed an RCT testing whether increased daily potato consumption influences energy balance [specifically, fat mass (FM)] compared with calorie-matched almond consumption.

Methods: A 30-d RCT of 180 adults prescribed calorie-matched (300 kcal/d, n = 60 participants/group) than consumed 1 of the following: 1) almonds (almond group), 2) French fries …

Comprehensive Genetic Analysis Of The Human Lipidome Identifies Loci Associated With Lipid Homeostasis With Links To Coronary Artery Disease, Gemma Cadby, Corey Giles, Phillip E. Melton, Kevin Huynh, Natalie A. Mellett, Thy Duong, Anh Nguyen, Michelle Cinel, Alex Smith, John Blangero

School of Medicine Publications

We integrated lipidomics and genomics to unravel the genetic architecture of lipid metabolism and identify genetic variants associated with lipid species putatively in the mechanistic pathway for coronary artery disease (CAD). We quantified 596 lipid species in serum from 4,492 individuals from the Busselton Health Study. The discovery GWAS identified 3,361 independent lipid-loci associations, involving 667 genomic regions (479 previously unreported), with validation in two independent cohorts. A meta-analysis revealed an additional 70 independent genomic regions associated with lipid species. We identified 134 lipid endophenotypes for CAD associated with 186 genomic loci. Associations between independent lipid-loci with coronary atherosclerosis were …

An Exploration Of Health Coaching Models And Their Efficacy In Chronic Disease Management: A Literature Review, Sofia Gallamore

University Honors Theses

Amidst the rise of chronic condition prevalence in recent decades, the field of health coaching has presented itself as a feasible complementary treatment method in chronic condition prevention and management. This literature review analyzes various clinical health coaching practices and their effectiveness in improving health behaviors and clinical outcomes in patients with chronic conditions. Eight studies were compared, with particular attention directed towards the evaluation of coaching techniques and modes of delivery. It was discovered that successful health coaching practices use a combination of Motivational Interviewing (MI), self-efficacy, and goal setting. Furthermore, programs that incorporated in-person intake sessions, followed by …

Multi-Phenotype Analyses Of Hemostatic Traits With Cardiovascular Events Reveal Novel Genetic Associations, Gerard Temprano-Sagrera, Colleen M Sitlani, William P Bone, Miguel Martin-Bornez, Benjamin F Voight, Alanna C Morrison, Scott M Damrauer, Paul S De Vries, Nicholas L Smith, Maria Sabater-Lleal

Faculty, Staff and Student Publications

BACKGROUND: Multi-phenotype analysis of genetically correlated phenotypes can increase the statistical power to detect loci associated with multiple traits, leading to the discovery of novel loci. This is the first study to date to comprehensively analyze the shared genetic effects within different hemostatic traits, and between these and their associated disease outcomes.

OBJECTIVES: To discover novel genetic associations by combining summary data of correlated hemostatic traits and disease events.

METHODS: Summary statistics from genome wide-association studies (GWAS) from seven hemostatic traits (factor VII [FVII], factor VIII [FVIII], von Willebrand factor [VWF] factor XI [FXI], fibrinogen, tissue plasminogen activator [tPA], plasminogen …

Atf4/Txnip/Redd1/Mtor Signaling Mediates The Antitumor Activities Of Liver X Receptor In Pancreatic Cancers, Zhikang Chen, Xiaobo Lai, Hui Ding, Aijun Zhang, Yufei Sun, Jianhua Ling, Paul J Chiao, Zihua Chen, Xuefeng Xia

Faculty, Staff and Student Publications

Background: Limited by difficulties in early detection and availabilities of effective treatments, pancreatic cancer is a highly malignant disease with poor prognosis. Nuclear receptors are a family of ligand-dependent transcription factors that are highly druggable therapeutic targets playing critical roles in human physiological and pathological development, including cancer. In this study, we explored the therapeutic potential as well as the molecular mechanisms of liver X receptor (LXR) agonist GW3965 in pancreatic cancer.

Methods: Soft-agar colony formation assay, xenograft tumors, Oligonucleotide microarray, Reverse transcription real-time polymerase chain reaction, Western immunoblotting and Immunohistochemistry were used in this study.

Results: We demonstrated pleotropic …

Osmotic Perturbation Promotes Competition Between Bacteria In Gut, Shaikh Obaidullah

Biology and Medicine Through Mathematics Conference

No abstract provided.

Animal-Assisted Programs In Deaf Education, Alexis Wright

Undergraduate University Honors Capstones

Dr. Boris Levinson first recognized animal-assisted therapy as a child psychologist in the 1970s (Fine, Beck, & Ng, 2019). After this recognition, there has been an increased usage of animal-assisted interventions (AAI), leading to more research in this field (Fine, Beck, & Ng, 2019). Many studies have shown the effects of animal-assisted programs in classrooms (Prothmann, Ettrich, and Prothmann, 2009, as cited in Grandin, Fine, O'Haire, Carlisle, & Bowers, 2015; Bassette & Taber-Doughty, 2016; Kirnan, Siminerio, & Wong, 2016; Kropp & Shupp, 2017), but none of these have focused on Deaf schools and programs. This study aims to partially fill …