Digital Commons Network^™

Benign Prostatic Hyperplasia (Bph): A Comprehensive Analysis Of The Malaise And Summarizing Possible Management Options Through Phytotherapeutic Agents, Shan Sasidharan, Kumarapillai Parameswaran Srinivasakumar, Sandeep Poddar, Amiya Bhaumik, Sreemoy Kanti Das, Hareendran Nair J

Kesmas

Benign prostatic hyperplasia (BPH) is a severe illness affecting middle-aged and geriatric male patients. This disease normally occurs at the age of 40 or above and is also associated with sexual dysfunction. Alpha-blockers and 5α-reductase inhibitors are the preferred drugs practiced to treat BPH. However, invasive surgical therapy remains the gold standard for managing the condition in the case of refractory and intricate BPH conditions. Due to the fear of sexual dysfunction and the detrimental influence on their quality of life, most patients seek to avoid synthetic drugs and surgery. For this reason, several patients turn to phytotherapy and other …

Infarct Diameter For Predicting Cognitive Dysfunction In Ischemic Stroke Survivors In West Nusa Tenggara, Indonesia, Herpan Syafii Harahap, Setyawati Asih Putri, Yanna Indrayana, Hasan Amin, Fransisca Ika Mahardika

Kesmas

Cognitive dysfunction is an important consequence of ischemic stroke, which can progress in the first few years and is primarily determined by clinical factors. This study aimed to investigate the clinical determinants of cognitive dysfunction in stroke survivors in West Nusa Tenggara Province, Indonesia. This cross-sectional study assessed 255 ischemic stroke survivors with a mean age of 57.1±9.3 years old and 29–79 years old, recruited consecutively in three main hospitals in West Nusa Tenggara Province between March 2019 and October 2021. Categorical data collected included age, sex, education level, clinical determinants of ischemic stroke, and cognitive status of the patients. …

Physician Orders For Life-Sustaining Treatment (Polst) Forms In A Primary Care Setting, Elena Johns

Doctor of Nursing Practice Final Manuscripts

Purpose: To increase completed POLST forms among elderly patients aged seventy-seven and older with chronic/debilitating illnesses, by at least 50% in a Primary Care clinic setting, from September 2021 to January 2022. Background: The government pays for over two-thirds of healthcare costs for the elderly aged sixty-five and older. Furthermore, by ages seventy to ninety, medical spending more than doubles. Many elderly and chronically ill patients report that they would prefer less aggressive treatment and more comfort care measures. However, patients also report a lack of knowledge about their end-of-life (EOL) wishes particularly when it comes to completing the Physicians …

The Association Between Loneliness With Increased Mental Health Problems And Substance Use During The Covid-19 Pandemic In Richmond, Virginia, Angela C. Liu, Connor Cox, Mariam Sankoh, James Clifford, Courtney T. Blondino, Chanel Bea, Chimere Miles, Kim Young, Sherika Gillison-Chew, John Richardson-Lauve, Candice Turner, Elizabeth Prom-Wormley

Virginia Journal of Public Health

Background. The COVID-19 pandemic caused significant psychological distress among U.S. adults leading to increased rates of adverse mental health symptoms and substance use. This study aims to evaluate the consistency of the association between loneliness and increased mental health problems and substance use in Richmond, VA during the COVID-19 pandemic.

Methods. Data were collected in two phases: 1) internet-based surveys from August 2020 to March 2021 (N=327) and 2) paper-pencil surveys from May to October 2021 (N=225). Logistic regression was used to test the association between loneliness and increased mental health and substance use, while adjusting for sociodemographic factors and …

The Hustler Award Program, Julia N. Biayi

Dissertations

Problem: Hospitalized adults are at increased risk of falling due to multiple aspects, including but not limited to changes in health status, the environment, pain, weakness, confusion, and prolonged immobility. This project focused on the question: How will the utilization of the Hustler Award Program decrease fall rates in an adult inpatient medical-surgical unit?

Method: A prospective quality improvement pilot study focused on a 24-bed medical-surgical unit in a Midwest, 487-bed metropolitan-based facility.

Results: The results captured are for the evaluation period occurring from September through November 2021. The staff responded to 52-bed exit alarms, which yielded a response rate …

Sex-Specific Mitochondrial Dynamics And Mitophagy Response To Muscle Damage, Hui Ying Luk, Nigel C. Jiwan, Casey R. Appell, Danielle E. Levitt, Jakob L. Vingren

School of Medicine Faculty Publications

Muscle damage imposes stress on mitochondria resulting in mitochondrial fusion, fission, and mitophagy. Testosterone is a regulator of these processes. However, no study has examined the effect of sex-specific resistance exercise (RE)-induced hormonal response on mitochondrial dynamics and mitophagy after muscle damage in untrained men and women. Untrained men and women performed two sessions of 80 unilateral maximal eccentric knee extensions (ECC) followed by upper-body RE (ECC+RE) aimed to induce hormonal changes and maintain a similar lower body demands between conditions or 20 min seated rest (ECC+REST). Vastus lateralis samples were analyzed for gene and protein expression of OPA1, MFN1, …

Interprofessional Collaboration With Occupational Therapy Assistant And Physical Therapist Assistant Students Through A Simulated Academic Setting, Brooke Gentry, Samantha Harris, Cindy Hayden, Allen Keener

International Journal of Health Sciences Education

Background: There is a direct emphasis on interprofessional learning and interprofessional education (IPE) at the accreditation and national level (IPE, 2016). There are, however, no studies on the effectiveness in the delivery of interprofessional collaboration in the academic setting, specific to occupational therapy assistant students. Therefore, the following research has been developed to address this area of need in occupational therapy assistant education.

Methods: This research was conducted in the academic setting, through a simulated lab-based case with occupational therapy assistant and physical therapist assistant students as the participants. The perceived confidence and communication were measured through a pre …

Louisiana State University Health Sciences Center - 2022 - 148th Commencement, Office Of The Registrar, Lsu Health Sciences Center-No

Graduation & Commencement Programs

The program for the 148th Commencement of LSU Health Sciences Center - New Orleans held May 19, 2022.

Exploring The Diet Dependent Role Of Oxidation Resistance 1 In Regulating Retromer Function, Enrique Carrera

Natural Sciences and Mathematics | Biological Sciences Master's Theses

Aging has been identified as a significant risk factor to the development of several diseases, such as neurodegeneration¹. One of the most common age-related neurodegenerative diseases is Alzheimer’s Disease (AD)², which causes cognitive decline. Current treatments for AD attempt to mitigate its symptoms or delay its onset^3–5. One method that has shown promise not only for the treatment of AD, but also for increasing lifespan and healthspan overall is dietary restriction (DR)⁶, but the mechanisms by which DR mediates these effects remains unclear^7,8. We have identified the human gene Oxidation …

Implementation Of A Primary Care Toolkit To Improve Dementia Diagnosis And Management In A Rural Setting, Meredith George-Wieland

Doctor of Nursing Practice Scholarly Projects

BACKGROUND: There are six million people with dementia living in the United States and this number is expected to rise exponentially due to the aging population. In the United States, it is estimated that only two thirds of dementia cases are recorded during primary care visits and an estimated, one third of cases have been either missed or disregarded.

LOCAL PROBLEM: In a remote primary care clinic on Kodiak Island, off the southeastern coast of Alaska, there is a lack of dementia and related cognitive diagnoses in the primary care setting due to patients’ and families lack access to the …

Micro-Computed Tomography Assessment Of Bone Structure In Aging Mice, Junbo Shim, Chihiro Iwaya, Catherine G Ambrose, Akiko Suzuki, Junichi Iwata

Faculty, Staff and Student Publications

High-resolution computed tomography (CT) is widely used to assess bone structure under physiological and pathological conditions. Although the analytic protocols and parameters for micro-CT (μCT) analyses in mice are standardized for long bones, vertebrae, and the palms in aging mice, they have not yet been established for craniofacial bones. In this study, we conducted a morphometric assessment of craniofacial bones, in comparison with long bones, in aging mice. Although age-related changes were observed in the microarchitecture of the femur, tibia, vertebra, and basisphenoid bone, and were more pronounced in females than in males, the microarchitecture of both the interparietal bone …

Estropause, Sex Hormones And Metal Homeostasis In The Mouse Brain, Tianbing Liu, Richard L. Bowen, Andrea C. Wilson, Craig S. Atwood

Research outputs 2022 to 2026

Alterations in brain metal ion homeostasis have been reported with aging and are implicated in the pathogenesis of neurodegenerative diseases. To assess whether age-related changes in hypothalamic-pituitary-gonadal (HPG) hormones might be involved in modulating brain metal ion homeostasis, we treated 7.5-month intact, sham-ovariecomized and ovariectomized C57B6SJL mice with vehicle or leuprolide acetate (for 9-months) to differentiate between whether sex steroids or gonadotropins might modulate brain metal ion concentrations. Unlike other aging mammals, there was no increase in plasma luteinizing hormone (LH) and follicle-stimulating hormone (FSH) concentrations following estropause in mice, suggesting there was sufficient residual production by the follicle depleted …

Implementation Of Delirium Bundle On A Hospital Medical/Surgical Unit To Help Decrease The Prevalence Of Delirium, Sanusi Mohammed

Doctor of Nursing Practice Scholarly Projects

Description of the Problem: Delirium is defined as a constellation of symptoms that includes disturbance in attention or awareness, change in cognition, language and perceptual disturbances that develops over a short period of time. Delirium mostly affects adult patients with risk factors including history of dementia, early cognitive impairment, dehydration, and infections. This quality improvement project was implemented on one hospital unit at a large tertiary hospital in the Boston area. This unit has one highest rate of delirium in the entire hospital system. Delirium is associated with high rate of morbidity and mortality. Also, this syndrome leads to longer …

Transitioning Eating Practices Of Older Adults, Michelle Lajoy Jackson

Dissertations

Purpose: The purpose of this descriptive qualitative study was to explore what factors may have influenced the transition of an individual older adult’s eating practices over a lifespan and the impact participants perceived those factors currently had upon their nutritional health in older adulthood.

Background: The older adult population is recognized as one of the fastest growing populations in the United States. One of many growing concerns for this population is the impact of dietary practices on the morbidity and mortality of this aging population. There is limited research to date that has explored the transitioning of appetite …

Barriers To Exercise And Physical Activity - Insight From The Rural Practitioner, Erin G. Tillery

Honors College Theses

Sedentary lifestyles are a growing public health concern. Furthermore, many rural Americans lack adequate access to healthcare resources. When healthcare is sought, the patient-practitioner interactions may serve to influence the patient’s lifestyle choices. The practitioners' exercise and physical activity habits may shape the effectiveness of the patient-practitioners interaction. Here, we explored the potential barriers to exercise and physical activity (PA) in licensed physical and occupational therapists. In addition, we aimed to describe barriers to exercise and PA in individuals with a history of stroke from the perspective of the practitioner. Lastly, how current exercise and physical activity habits influence their …

An Exploratory Look Into The Effects Of Mississippi's Population Decline On Rural Dental Care, Allen Bailey Saffold

Honors Theses

Literature reviews and interviews with dentists working in rural Mississippi counties examined the effects of population decline on rural dental care in Mississippi. With the state’s continual population decline, loss of industry follows a loss of people. Through a cascade of effects, this can further reduce underserved areas’ access to dental care. In order to address the issue of rural Mississippi continuing to be underserved, policies need to be implemented that will make rural practice at least enticing if not desirable.

The Effects Of Astrocytic Derived Insulin-Like Growth Factor (Igf-1) On Cognition And Astrocytes, Destiny Wilson

Honors Theses

Insulin-like growth factor 1 (IGF-1) is a neuroendocrine signaling hormone that plays a vital role in growth and development, as well as learning and memory. Inhibition of this hormone results in cognitive impairments like those seen with age-related decline. While a majority of research has focused on the role of IGF-1 on neurons, the role of astrocytes still needs to be explored. Our research investigates how astrocytes and cognition are affected as a result of direct regulation of localized IGF-1 production in early development and after puberty. Preliminary studies in our laboratory established a connection between IGF-1 and glial fibrillary …

Ageism, Eldercare, And Healthcare: An Examination Of Growing Old In Costa Rica, Akshaya Vijayasankar

Honors Theses

The world’s aging population and the Covid-19 pandemic have revealed the high level of ageism against older adults around the globe, which has resulted in an overall decreased quality of life for elders. Societies are now faced with the challenge of creating a suitable and equitable model of care to support their aging population. Despite the recent publication of the World Health Organization's Global Report on Ageism, there is still a large gap in the literature regarding ageism. This paper addresses the issues of institutional ageism in the eldercare and healthcare sector. I argue that Costa Rica serves as a …

Implementation And Evaluation Of An End-Of-Life Standardized Participant Simulation Into An Adult/Gerontology Acute Care Nurse Practitioner Program, Shannon Daly

Doctor of Nursing Practice (DNP) Translational and Clinical Research Projects

Palliative care interventions are in high demand due to patients living longer with chronic, life-limiting conditions. Nursing professionals are instrumental in the care of patients across their lifespan, and it is imperative that they receive end-of-life care training in their respective curriculums. The aims of this project were to 1) implement end-of-life content into an AGACNP program using the ELNEC curriculum and 2) to determine if the simulated environment affects the AGACNP students’ self-confidence and anxiety levels when making clinical decisions for end-of-life patients. As a result of the standardized participant (SP) end-of-life simulation, AGACNP students experienced an increase in …

Factors Associated With Advance Care Planning Engagement In Healthy Young Adults, Pablo J. Vasquez

Dissertations and Theses (Open Access)

Background: Advance care planning (ACP) is a process that supports individuals at any stage of health in understanding and sharing their personal values and goals pertaining current or future medical needs with their families and healthcare providers. Although ACP is applicable to adults of any age and any stage of the health continuum, it is widely associated with older or terminally ill populations, and the need for end-of-life (EOL) planning in healthy young adults is generally found unnecessary. The National Institutes of Health supports the expansion of ACP research in understudied populations. Investigating ACP in healthy young adults support such …

Conducting A Root Cause Analysis To Improve Intake Processes And Record Review In Home Health, Christina Guerrero

Doctor of Nursing Practice Projects

Minimization of adverse events, reduction of inpatient admissions, and prevention of polypharmacy within home health are of importance due to the increasing number of Medicare beneficiaries. In 2019, CMS reported 5,266,931 patients were served by home health agencies, accounting for 7,439,849 episodes of care. It is projected that the number of beneficiaries will rise from 54 million to more than 80 million by the year 2030. Medical errors are now the third-leading cause of death in the United States, surpassing diabetes, Alzheimer’s, and stroke. The Agency for Healthcare Research and Quality identifies a lack of institutional intake processes as the …

Telemedicine Across Borders: Entrenched Issues Exposed By Covid-19, Richmond B. Wrinkle

Georgia Journal of International & Comparative Law

No abstract provided.

A Preliminary Report: The Hippocampus And Surrounding Temporal Cortex Of Patients With Schizophrenia Have Impaired Blood-Brain Barrier, Eric L. Goldwaser, Randel L. Swanson, Edgardo J. Arroyo, Venkat Venkataraman, Mary C. Kosciuk, Robert G. Nagele, L. Elliot Hong, Nimish K. Acharya

Rowan-Virtua Research Day

Schizophrenia (SZ) is one of the most severe forms of mental illness, yet mechanisms remain unclear. A widely established brain finding in SZ is hippocampal atrophy, and a coherent explanation similarly is lacking. Epidemiological evidence suggests increased cerebrovascular and cardiovascular complications in SZ independent of lifestyle and medication, pointing to disease-specific pathology. Endothelial cell contributions to blood-brain barrier (BBB) compromise may influence neurovascular unit and peripheral vascular function, and we hypothesize that downstream functional and structural abnormalities may be explained by impaired BBB.

The Brodmann Area 39/40 Of The Brain In Alzheimer’S, Mild Cognitive Impairment, And No Cognitive Impairment Subjects At Advanced Age Demonstrate Comparable Levels Of Blood-Brain Barrier Breach, Dhara Rana, Forum Mangrola, Randel L. Swanson, Venkat Venkataraman, David A. Bennett, Zoe Arvanitakis, David Libon, Robert Nagele, Nimish Acharya

Rowan-Virtua Research Day

• Alzheimer’s disease (AD) is one of the most common form of dementia

• Mild cognitive impairment (MCI), specifically amnestic subtype, more likely to progress to AD

• Pathogenesis Theories:

• o Accumulation of amyloid-beta peptides and neurofibrillary tangles containing hyperphosphorylated neuronal tau protein
• o Blood Brain Barrier (BBB) dysfunction is associated with AD pathogenesis

• Brodmann area 39/40: regions of parietal cortex are responsible for language, spatial cognition, memory retrieval, attention, phonological processing, and emotional processing

• Hypothesis: An increased BBB permeability in Brodmann area 39/40 of AD and age-matched MCI and no cognitive impairment (NCI) subjects

Nsu Health Professions Division 2021-2022 Course Catalog, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Global Developments In Social Prescribing, Daniel F. Morse, Sahil Sandhu, Kate Mulligan, Stephanie Tierney, Marie Polley, Bogdan Chiva Giurca, Siân Slade, Sónia Dias, Kamal R. Mahtani, Leanne Wells, Huali Wang, Bo Zhao, Cristiano Emanuel Marta De Figueiredo, Jan Joost Meijs, Hae Kweun Nam, Kheng Hock Lee, Carolyn Wallace, Megan Eliott, Juan Manuel Mendive, David Robinson, Miia Palo, Wolfram Hermann, Rasmus Østergaard Nielsen, Kerryn Husk

Applied Computer Science | Faculty Scholarship

Social prescribing is an approach that aims to improve health and well-being. It connects individuals to non-clinical services and supports that address social needs, such as those related to loneliness, housing instability and mental health. At the person level, social prescribing can give individuals the knowledge, skills, motivation and confidence to manage their own health and well-being. At the society level, it can facilitate greater collaboration across health, social, and community sectors to promote integrated care and move beyond the traditional biomedical model of health. While the term social prescribing was first popularised in the UK, this practice has become …

Reducing Medication Non-Adherence With Improved Health Literacy Interventions: An Evidence-Based Practice Quality Improvement Project, Unity Wiles

DNP Projects

Introduction

Health literacy is the ability to obtain, process, and understand basic health information and services needed to make appropriate healthcare decisions and follow instructions for treatment. Patients with low health literacy have been predicted to have poor health outcomes. The inclusion of the single-item literacy tool into the admission process of this project involved the patient-centered-care characteristics of improved patient experience, lower health cost, improved clinical experience, and better outcomes.

Purpose

The National Action Plan to improve Health Literacy seeks to engage organizations, professionals, policymakers, communities, individuals, and families in a linked multi-sector effort to improve health literacy. Low …

Systematic Literature Review: Culturally Appropriate Approach To Advance Care Planning For Ponca Tribe Elders, Priscila Soto Prado

Capstone Experience: Master of Public Health

Advance Care Planning is understudied in Native American and Alaskan Natives communities. There is a strong need for further research on culturally adapting advance care planning (ACP) for indigenous communities. Specifically, for the Ponca Tribe, culturally adapting the ACP used would ideally increase the acceptance of ACP in that community. This systematic literature resulted in identifying four themes other tribes have utilized to culturally adapt their ACP, advance directive, palliative and/or end-of-life processes in an effort to increase completion rates. The four themes were involving the elders with the adaptation process, increasing education efforts and awareness of ACP and ADs, …

A Quantitative Job Satisfaction Comparison Between Certified Nursing Assistants (Cnas) Providing Care In Patients’ Homes Versus In Long-Term Care (Ltc) Facilities In The Omaha Metropolitan Area, Rusheena Shah

Capstone Experience: Master of Public Health

This capstone project looks at overall job satisfaction comparison between two groups of Certified Nursing Assistants (CNAs) – CNAs who provide home care in patients’ homes and CNAs who provide care in Long-term Care (LTC) facilities in the Omaha Metropolitan Area. In this quantitative study, a survey was sent to CNAs who provide home care to patients and CNAs who provide patient care at different nursing home facilities in the Omaha area. Prior research has indicated that even though CNAs perform similar job duties irrespective of the work environment; they experience varying degrees of job satisfaction which could be attributed …

Effects Of Increased Levels Of Relaxin Hormone In Women During Pregnancy In Relation To Spondylolisthesis: A Literature Review, Joselin R. Guerrero Rapalo

Honors Theses

No abstract provided.