Digital Commons Network^™

Diagnostic Power Of Serum Creatinine/Cystatin C Ratio For Identifying Low Mri-Muscle Volume And Low Grip Strength: Data From 9 731 To 149 707 Uk Biobank Older Adults, Ben Kirk, Chia Ling Kuo, Peiran Liu, Meiruo Xiang, Jesse Zanker, Konstantinos Prokopidis, Marc Sim, Richard H. Fortinsky, George A. Kuchel, Gustavo Duque

Research outputs 2022 to 2026

Background: Biomarkers for sarcopenia are lacking. We examined the diagnostic power of serum creatinine to cystatin C ratio for identifying low magnetic resonance imaging-muscle volume and low grip strength in a large observational study of UK Biobank older adults.

Methods: Serum creatinine and cystatin C were measured via immunoassays (Beckman Coulter AU5800 and Siemens Advia 1800, respectively) and grip strength by hydraulic hand dynamometer at baseline visit (2008-2010). magnetic resonance imaging-thigh fat-free muscle volume and DXA-derived appendicular lean mass were measured at imaging visit (2014-2018). Extreme outliers were removed, and covariates (demographic, lifestyle, and clinical factors, as well as time …

The Scientific Landscape Of The Aging-In-Place Literature: A Bibliometric Analysis, Saman Jamshidi, Nastaran Hashemi

Architecture Faculty Research

The world’s population is aging and, as populations age, they exhibit an increased prevalence of chronic diseases, which can reduce the independence of elderly individuals. The set of initiatives known as aging in place, a common policy response to the aging population, is preferred by both the elderly population and policymakers. Aging in place is a broad and multifaceted topic that involves multiple stakeholders and academic disciplines. A science map of the literature on aging in place can help researchers pinpoint their efforts and help policymakers make informed decisions. Thus, this study maps the scientific landscape of the aging-in-place literature. …

Contextualizing Adolescent’S Experiences Of Dementia In England, Esra Hassan, Ben Hicks, Naji Tabet, Nicolas Farina

Peninsula Medical School

Adolescents represent an under-researched group that mayalready have experiences of dementia. In this study, we aimedto capture adolescents’ level of contact (frequency) and qualityof contact (whether experiences were positive or negative) withpeople living with the condition. In this cross-sectional study,1,371 adolescents (aged 11–18 years old) across England wererecruited. Descriptive statistics, cross-tabulations, and regres-sions were employed to explore the association between socio-demographic factors and the frequency and quality of dementiacontact in adolescents. Over 64% of adolescents had comeacross people living with dementia, while over a quarter ofadolescents had looked after someone living with the condition.The level of contact and quality of …

Faculty Senate Chronicle December 5, 2024, Heather Loughney

The University of Akron Faculty Senate Chronicle

Minutes for the regular meeting of The University of Akron Faculty Senate on December 5, 2024

How To Design A Program For The Poor That Is Not A Poor Program: Explaining The Political Sustainability Of The Guaranteed Income Supplement, Daniel Béland, Patrik Marier

Osgoode Hall Law Journal

Created in 1967 as a temporary program aimed at supporting low-income people during the maturation of the Canada and Quebec Pension Plans, the Guaranteed Income Supplement (GIS) has since become a permanent policy that remains a central component of Canada’s multi-layered public pension system. In this article, we explain why GIS is a popular and politically successful program that challenges the common wisdom in political science and policy analysis that “programs for the poor are poor programs.” The article shows that the success of GIS stems from its policy design (e.g., income-tested rather than means-tested benefits), the social construction of …

The Canada Disability Benefit: Battling Ableism In Design And Implementation, Jennifer Robson, Lindsay Tedds

Osgoode Hall Law Journal

This article, written shortly after the framework legislation for the Canada Disability Benefit was introduced, discusses the key benefit design elements and options facing policymakers. We contrast these elements with the directional parameters set in the legislation. In the intervening months, the Government of Canada released an estimate of the annual costs of the new benefit and eventually drafted regulations that detail the actual design of the benefit in the Summer of 2024. These developments are outside the scope of this article, but the analysis in this article provides a foundation for other researchers and stakeholders to interpret and critique …

'T-W-O': External Challenges And Coping Strategies Of Chinese Social Work Service Organisations During The Epidemic, Bin Xu, Bowen Mcbeath, Haobo Xi

School of Social Work Faculty Publications and Presentations

During the peak years of COVID-19, Chinese social work service organisations actively participated in the preventing and controlling of the pandemic. These organisations also faced external challenges that reflected changing public health policies, contractual and fiscal changes, and immense service needs. This paper describes the specific external challenges that a purposive sample of 11 Beijing-based social work service organisations experienced because of the pandemic, as well as the strategies they used to address them. We find that project and fiscal precarity were the greatest external risks faced by social service organisations. In order to mitigate these concerns, the organisations actively …

The Minutes Of The Marshall University Board Of Governors Meeting, December 4, 2024, Marshall University Board Of Governors

Board of Governors Minutes

No abstract provided.

The Relations Between The Financial Wellbeing Of Custodial Grandparents, Their Overall Wellbeing, And Their Perceived Social Support, Paige L. Miller

Honors Theses

There have been numerous studies on how the financial wellbeing of custodial grandparents affects their overall wellbeing, and how the amount of social support custodial grandparents receive impacts their depressive and anxiety symptoms. However, little is known regarding the ways in which all three variables are related – financial wellbeing, overall wellbeing, and social support – or their impact on custodial grandparents. We examined the relations between these variables, as well as the moderating relation of financial wellbeing on social support and wellbeing. The data used in the current study was collected as part of a larger project, during which …

A Review Of The Association Between Dietary Intake And Brain Iron Levels In Older Adults: Preliminary Findings And Future Directions., Valentinos Zachariou, Christopher E. Bauer, Colleen A. Pappas, Brian T. Gold

Behavioral Science Faculty Publications

Background/Objectives: Non-heme iron is essential for critical neuronal functions such as ATP generation, synaptogenesis, neurotransmitter synthesis, and myelin formation. However, as non-heme iron accumulates with age, excessive levels can contribute to oxidative stress, potentially disrupting neuronal integrity and contributing to cognitive decline. Despite growing evidence linking high brain iron with poorer cognitive performance, there are currently no proven methods to reduce brain iron accumulation in aging or to protect cognitive function from iron’s negative effects. Recent studies suggest that nutrition may influence brain iron levels, though the evidence remains limited and mixed. Methods: In this review, we explore recent findings, …

Top 7 Things To Know About Frailty In The Emergency Department, Brandon J. Bukovitz

Journal of Geriatric Emergency Medicine

n/a

Urinary Metal Levels, Cognitive Test Performance, And Dementia In The Multi-Ethnic Study Of Atherosclerosis, Arce Domingo-Relloso, Katlyn E Mcgraw, Susan R Heckbert, Jose A Luchsinger, Kathrin Schilling, Ronald A Glabonjat, Irene Martinez-Morata, Melanie Mayer, Yongmei Liu, Alexis C Wood, Jeff Goldsmith, Kathleen M Hayden, Mohamad Habes, Ilya M Nasrallah, R Nick Bryan, Tanweer Rashid, Wendy S Post, Jerome I Rotter, Priya Palta, Linda Valeri, Timothy M Hughes, Ana Navas-Acien

Faculty, Staff and Students Publications

IMPORTANCE: Metals are established neurotoxicants, but evidence of their association with cognitive performance at low chronic exposure levels is limited.

OBJECTIVE: To investigate the association of urinary metal levels, individually and as a mixture, with cognitive tests and dementia diagnosis, including effect modification by apolipoprotein ε4 allele (APOE4).

DESIGN, SETTING, AND PARTICIPANTS: The multicenter prospective cohort Multi-Ethnic Study of Atherosclerosis (MESA) was started from July 2000 to August 2002, with follow-up through 2018. A total of 6303 MESA participants were included. Data analysis was performed from October 12, 2023, to June 13, 2024.

EXPOSURE: Urine samples were collected at baseline …

Major Depressive Disorder And Driving Behavior Among Older Adults, Ganesh M Babulal, Ling Chen, Jean-Francois Trani, David C Brown, David B Carr, Beau M Ances, Eric J Lenze, Drives Project

2020-Current year OA Pubs

IMPORTANCE: Depression and antidepressant use are independently associated with crash risk among older drivers. However, it is unclear what factors impact daily driving that increase safety risk for drivers with depression.

OBJECTIVE: To examine differences in naturalistic driving behavior and safety between older adults with and without major depressive disorder (MDD).

DESIGN, SETTING, AND PARTICIPANTS: A prospective longitudinal cohort study was conducted among older adults (≥65 years) from the Driving Real-World In-Vehicle Evaluation System Project collected from July 1, 2021, to December 30, 2023. The sample included 85 participants with MDD and 310 participants without. Neurological, clinical, mood, and neuropsychological …

A Scoping Review Of The Prevalence Of Polypharmacy In Dementia Patients In Correlation To Increased Falls And Hospitalizations, Julie Ward, Travis Adelman, Erica Barber, Elizabeth Upton

Doctor of Medical Science (DMSc)

Dementia is a progressive neurodegenerative condition characterized by cognitive decline and behavioral changes, which often necessitates polypharmacy to manage symptoms. There is a negative trade off to polypharmacy in that it increases the risks of falls and hospitalizations. Dementia patients are at an increased risk of falls and hospitalization, making it valuable to examine admission records to identify potentially modifiable risk factors. One of the most prevalent modifiable risk factors is polypharmacy in geriatric populations. Polypharmacy has become prevalent in older adults, not just in dementia. In 2013 a 3-year prospective cohort study of 1,742,336 people >65 years old looked …

Navigating Menopause: Bridging The Gap Between Healthcare Practitioners And Black Women For Improved Clinical Support And Health Equity, Yejide Nelson-Glenn

MSW Capstone Conference

No abstract provided.

Donald Griffin: A Visionary In Science And Consciousness, Brock Fenton

Animal Sentience

I share some reflections on a sabbatical with Donald Griffin a half-century ago, with fieldwork on bats and echolocating swiftlets in Australia and our discussions of animal behavior and consciousness. Griffin's influence has been vast, from recent advances in bat research, including learning, navigation, and longevity, to his enduring legacy as a pioneer in animal cognition.

Urinformed December 2024, Urinformed

URInformed: The URI Employees' Newsletter

No abstract provided.

Exploring Gerotranscendence And End-Of-Life Choices: A Mixed-Methods Study On The Influence Of Health Literacy In Older Adults, Dyna C. Crease, Ashia Daniels

MSW Capstone Conference

No abstract provided.

Expanding Sensory Kit Utilization Across Age And Contexts: Bridging Gaps For Inclusive Accessibility, Piper Hutson, James Hutson

Faculty Scholarship

Sensory kits, initially developed for neurodivergent children, have seen growing integration into various educational, cultural, and therapeutic contexts. However, their broader applicability, particularly for adults and diverse populations, remains underexplored. This study examines existing practices in the design and use of sensory kits within academic, museum, and inclusion frameworks, highlighting their role in promoting focus, reducing anxiety, and supporting self-regulation. Using case studies from institutions such as the Smithsonian and the Metropolitan Museum of Art, alongside a review of evidence-based interventions like weighted items and fidget tools, the research underscores the potential of these tools in diverse environments. The methodology …

Investigating Impacts Of The Mycothiazole Chemotype As A Chemical Probe For The Study Of Mitochondrial Function And Aging., Naibedya Dutta, Joe A Gerke, Sofia F. Odron, Joseph D. Morris, Adam Hruby, Juri Kim, Toni Castro Torres, Sarah J. Shemtov, Jacqueline G. Clarke, Michelle C. Chang, Hooriya Shaghasi, Marissa N. Ray, Maxim Averbukh, Sally Hoang, Maria Oorloff, Athena Alcala, Matthew Vega, Hemal H Mehta, Max A Thorwald, Phillip Crews, Marc Vermulst, Gilberto Garcia, Tyler A. Johnson, Ryo Higuchi-Sanabria

Natural Sciences and Mathematics | Faculty Scholarship

Small molecule inhibitors of the mitochondrial electron transport chain (ETC) hold significant promise to provide valuable insights to the field of mitochondrial research and aging biology. In this study, we investigated two molecules: mycothiazole (MTZ) - from the marine sponge C. mycofijiensis and its more stable semisynthetic analog 8-O-acetylmycothiazole (8-OAc) as potent and selective chemical probes based on their high efficiency to inhibit ETC complex I function. Similar to rotenone (Rote), MTZ, a newly employed ETC complex I inhibitor, exhibited higher cytotoxicity against cancer cell lines compared to certain non-cancer cell lines. Interestingly, 8-OAc demonstrated greater selectivity for cancer cells …

University Of Nebraska At Omaha Commencement: December 2024, University Of Nebraska At Omaha

Commencement Programs

No abstract provided.

Graduate List - December 2024, University Of Nebraska At Omaha

Commencement Lists

No abstract provided.

Correction To: Polygenic Effects On The Risk Of Alzheimer’S Disease In The Japanese Population (Alzheimer's Research & Therapy, (2024), 16, 1, (45), 10.1186/S13195-024-01414-X), Masataka Kikuchi, Akinori Miyashita, Norikazu Hara, Kensaku Kasuga, Yuko Saito, Shigeo Murayama, Akiyoshi Kakita, Hiroyasu Akatsu, Kouichi Ozaki, Shumpei Niida, Ryozo Kuwano, Takeshi Iwatsubo, Akihiro Nakaya, Takeshi Ikeuchi, Michael W. Weiner, Sara S. Mason, Colleen S. Albers, David Knopman, Kris Johnson, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Lon S. Schneider, Sonia Pawluczyk, Mauricio Beccera, Liberty Teodoro, Bryan M. Spann, Laurel Beckett, Robert C. Green, John Morris, Leslie M. Shaw

Clinical Research Faculty Publications

Following publication of the original article [1], the authors corrected an error in Fig. 2. (Figure presented.) The PRS.noAPOE and PRS.adjLD correlated with CSF Tau/Aβ42 ratios in the MCI. CSF tTau/Aβ42 (A, C) and pTau/Aβ42 (B, D) ratios by decile of PRS are shown in each diagnostic group. The participants were divided into ten groups based on the PRS.noAPOE, ranging from the lowest group (1st decile) to the highest group (10th decile). CN = cognitively normal; MCI = mild cognitive impairment; ADD = Alzheimer’s disease dementia Error: Figs. 2C and D are the same figures as Figs. 2A and B …

Livable Marshfield: Age And Dementia Friendly Action Plan: Improving Livability For All Ages And Abilities, Caitlin E. Coyle, Beth Rouleau, Ceara Somerville

Center for Social and Demographic Research on Aging Publications

The Town of Marshfield’s Age and Dementia Friendly action plan signifies a milestone and reflects many years of dedication to creating environments within Marshfield that are supportive of residents of all ages and abilities. Guided by the Council on Aging (COA), the Town of Marshfield is dedicated to understanding and responding to the needs and interests of older adults in the community. Over the years, the share of residents over age 60 has steadily grown. According to 2019-2023 estimates from the American Community Survey, an estimated 28% of Marshfield residents are age 60 or older (approximately 7,200 residents). Projections suggest …

Study Of The Effect Of Social Anxiety And Social Support On Third Place Perceptions In Student Samples, Lillian M. Lestrange

Honors Theses

Social Anxiety Disorder (SAD) and perceived social support are well-documented to influence social interaction styles and behaviors. Some data suggests that SAD and social support relate to perceptions and familiarity with various public spaces outside of home and work (i.e., third places). This study assessed relations among social anxiety, self-perceived social support, and attitudes/beliefs about ten common third places (i.e., perceived degree of restorativeness, preference, and sentiment for these places) among undergraduate psychology students (n = 92). Contrary to predictions based on prior research (Fong et al, 2021, Case & Hunter, 2012), social anxiety symptoms did not correlate with any …

The Effects Of Individual Differences In Working Memory On Trust Recovery, Connie Ku

All Theses

While trust repair is an active area of inquiry, most technology does not have the ability to initiate trust repair. Thus, it is crucial to examine how unaided trust recovery occurs and the factors that could influence it. Prior research has highlighted the potential importance of individual difference factors such as working memory capacity (e.g., Rovira, Pak, McLaughlin, 2017). However, the specific dynamics of unaided trust recovery and how they are influenced by individual differences are unknown. This study examined how working memory (WM) was related to the process of unaided trust recovery. In addition, this study also examined the …

Patterns Of Activity Participation And The Well-Being Of Older Adults In Singapore, Zidane Tiew, Rachel Ngu, Yi Wen Tan

ROSA Research Briefs

Older adults participate in different types of activities and do so in varying frequencies. In this study, we utilised latent class analysis to identify underlying patterns of activity participation among the SLP respondents. We found three patterns: (i) generally active (i.e., socially, physically, and digitally active), (ii) physically and digitally active, and (iii) digitally active. Furthermore, we found that respondents who were more broadly active were more likely to experience higher levels of life satisfaction than those who were only digitally active. These respondents tended to be from higher socioeconomic backgrounds, report having better health, or had more close social …

A Report Summarizing Hsc Faculty Participants: Ithaka S+R Coordinated Study Making Ai Generative For Higher Education, Laura J. Hall, Robyn Gleasner

Publications

This report presents findings from the University of New Mexico Health Sciences Center’s (HSC) participation in the ITHAKA S+R study Making AI Generative for Higher Education. Seven faculty members from HSC disciplines including internal medicine, pathology, psychiatry, nursing, radiology, and population health were interviewed to explore their perspectives on generative AI (GenAI) in teaching and learning, research and scholarship, and institutional support. A unique theme of “practice” emerged, reflecting how GenAI is influencing clinical care, bench-to-bedside translation, and the preparation of students for future professional practice. The report highlights faculty experiences, ethical concerns, and support needs, offering insight into how …

“Being With God”: Prayer Biographies, Mysticism In Old Age, And Compassionate Love Among Older Jesuits, Stephen John Fogle

Gerontology Theses, Dissertations, and Student Creative Activity

This dissertation explores lived experiences of prayer and aging among older Jesuits from a religion, spirituality, and aging perspective in five chapters. Chapter One opens with a review of prayer in gerontological literature. The chapter recommends attention to prayer in life course perspective, details of prayer in old age as a relationship with divinity, and appreciation of religious and spiritual outcomes of aging. The chapter concludes with an overview of research with older Jesuits of the Upper Midwest. Chapter Two presents prayer biographies of older Jesuits in life course perspective. The chapter discusses how age stages, relationships, historical events, and …

Adverse Childhood Experiences And Early Life Adversity And Their Effects On Chronic Health: A Literature Review, Ella Weatherford

The Eleanor Mann School of Nursing Undergraduate Honors Theses

With more than 439,000 annual U.S. deaths associated with childhood adversity, it is important to understand and prevent exposure to Adverse Childhood Events and Early Life Adversity. The purpose of this literature review is to identify and examine the pathophysiology between adverse childhood experiences (ACE’s) and their negative effects on health across the lifespan. Fifteen peer-reviewed articles that were published in notable journals were analyzed to include in this review. The results of these articles show that Adverse Childhood Experiences and Early Life Adversity can lead to the development of chronic inflammatory conditions across the lifespan. Using Barker Hypothesis and …