Digital Commons Network^™

The Relationship Of Trait-Like Compassion With Epigenetic Aging: The Population-Based Prospective Young Finns Study, Henrik Dobewall, Liisa Keltikangas-Järvinen, Saara Marttila, Pashupati P. Mishra, Aino Saarinen, C. Robert Cloninger, Igor Zwir, Mika Kähönen, Mikko Hurme, Olli Raitakari, Terho Lehtimäki, Mirka Hintsanen

School of Medicine Publications

Introduction: Helping others within and beyond the family has been related to living a healthy and long life. Compassion is a prosocial personality trait characterized by concern for another person who is suffering and the motivation to help. The current study examines whether epigenetic aging is a potential biological mechanism that explains the link between prosociality and longevity.

Methods: We used data from the Young Finns Study that follows six birth-cohorts from age 3–18 to 19–49. Trait-like compassion for others was measured with the Temperament and Character Inventory in the years 1997 and 2001. Epigenetic age acceleration and telomere …

The Hero’S Journey As A Novel, Narrative, And Improvisational Group Intervention On Quality Of Life For People With Parkinson’S Disease, Robert D. Cochrane, James W. Navalta, Anne E. Weisman

Heroism Science

Parkinson’s disease (PD) is one of the fastest-growing neurological diseases in the world. Pharmaceutical and surgical interventions continue to advance to better address motor symptoms. However, disability from non-motor symptoms, such as depression, anxiety, and stress persist. Expressive therapies, including art, music, and dance are being explored and implemented more frequently to address this growing need. We developed this study to examine the feasibility of a novel program using online narrative therapy, with constructs from Joseph Campbell’s Hero’s Journey, and improvisation for people with PD (PWPD). Participants from across the U.S. and U.K. met online via Zoom once a week …

Exploring Factors Influencing Nursing Engagement In 4ms Initiatives On An Inpatient Older Adult Unit, Sarah Nelson

DNP Projects

Background: The older adult population is growing, and these individuals often have health challenges that require complex nursing care. On an older adult unit in Tennessee, a 4Ms (What Matters, Medication, Mentation, and Mobility) Age-Friendly care initiative was implemented to improve care and outcomes. Early data showed inconsistent nursing engagement with 4Ms initiatives and qualitative data on engagement factors was needed to increase nursing support and improve patient outcomes. Purpose: Therefore, this scholarly project explored factors influencing nursing staff engagement with the 4Ms initiative on an older adult unit. Methods: Nurses and …

A Program To Improve The Quality Of Life Of Caregivers Of Older Adults With Chronic Conditions: A Pilot Study, Lori Reynolds, Brandi Buchanan, Shannon Crabtree, Elton Bordanave

The Open Journal of Occupational Therapy

Background: Among the nearly 41.8 million family caregivers of older adults 50 years of age and older in the United States, only 30% of caregivers report receiving the education, resources, and support they need to feel competent in their role. Many existing programs focus on dementia-related caregiving, and programs are needed to address the caregiving needs of individuals with chronic conditions.

Method: A pilot study using a mixed methods design was conducted with eight participants. The pre and post. measure, Adult Carer Quality of Life (AC-QoL), and post program individual interviews were conducted.

Results: Six of the …

Education And Perceptions Of Post-Therapy Maintenance Programs In Long-Term Care: A Mixed Methods Exploratory Study, Laura S. Novak, Vanessa D. Jewell, Michael Gerg, Andrea Thinnes

The Open Journal of Occupational Therapy

Background: Occupational therapists develop maintenance programs (MPs) for long-term care (LTC) residents to optimize participation in everyday activities. The purpose of this study was to examine nursing professional attitudes and knowledge of MPs and to evaluate the effectiveness of an occupational therapist-led in-service.

Method: Nursing staff (n = 20) attended the in-service, completed a pre and posttest, and completed interviews (n = 5). We used an exploratory sequential mixed methods design with a one-group quasi-experimental design for the quantitative portion and a descriptive qualitative approach for the interviews.

Results: The results indicated significantly increased knowledge regarding MPs, …

Occupational Therapists' Perspectives On Nursing Home Culture And Addressing The Psychosocial Needs Of Residents: Mixed Methods Design, Nayeli Mendoza, Mikayla C. Wandersee, Divya Sood

The Open Journal of Occupational Therapy

Background: The purpose of this study was to explore occupational therapists’ perspectives on the culture change movement to address the psychosocial components of care among nursing home residents and identify supports and barriers to implementing the culture change movement.

Methods: We used a sequential explanatory mixed methods design. Electronic surveys were completed by 102 occupational therapists who work in nursing home facilities. Three focus groups were conducted via conference call with occupational therapists (n = 9). The survey was analyzed using descriptive statistics and content analysis. Focus groups were analyzed using thematic analysis.

Results: Seventy-four of survey …

Air Temperature And Diet Are Not Associated With Oxygen Consumption Rate In Banded Crickets, Gryllodes Sigillatus, Nicole Bailey, Connor Oakes, Rachel Sleeth, Mallorie Smith

Butler Journal of Undergraduate Research

All living organisms acclimate to their environments, with ectothermic species particularly susceptible to environmental change, specifically temperature. Ectothermic insects like crickets directly alter their physiological processes depending on the environment in which they live. Temperature is vital in regulating processes such as metabolism, respiration, and reproduction, among other things. What remains unclear is how a change in the environment, specifically extreme temperature change and dietary alterations, affects physiological processes. In this study, we performed experiments on ectothermic banded crickets to examine the effects of temperature change and the interaction of temperature and diet on oxygen consumption. For both experiments, we …

Work-Life And Health Experiences Of Computer Science Faculty Parents Of Children With Developmental Disabilities During Covid-19, Molly Armstrong

Butler Journal of Undergraduate Research

Prior to the COVID-19 pandemic, parents of children with developmental disabilities (PCDD) had been shown to experience more stress than parents of children without developmental disabilities (non-PCDD). COVID-19 may have exacerbated difficulties for PCDD. To compare differences in COVID-19 experiences between PCDD and non-PCDD, 202 parents working as computer science (CS) faculty reported their experiences of mental health symptoms, physical health symptoms, work-life conflict levels as experienced during the pandemic, and any changes in their childcare responsibilities because of COVID-19. Participants completed surveys on their experiences during Fall 2020 and Spring 2021, the first academic year after the start of …

Sleep Apnea And Substance Use Disorders Associated With Co-Occurrence Of Anxiety Disorder And Depression Among U.S. Adults: Findings From The Nsduh 2008–2014, Chun Xu, Priscila Acevedo, Liang Wang, Nianyang Wang, Kaysie Ozuna, Saima Shafique, Annu Karithara, Victoria I. Padilla, Chunxiang Mao, Xin Xie, Kesheng Wang

Health & Biomedical Sciences Faculty Publications

Few studies have focused on sleep apnea and substance use disorders with co-occurrence of anxiety disorder and depression. This study included a total of 270,227 adults, 9268 with co-occurrence of anxiety disorder and depression in the past year, from the combined 2008–2014 National Survey on Drug Use and Health (NSDUH) data, which are the latest datasets with measures of anxiety disorder and sleep apnea. Weighted multinomial logistic regression analyses were used to estimate the associations between anxiety disorder and depression and their co-occurrence. Comorbidity was highly prevalent: 40.4% of those with depression also met the criteria for anxiety disorder, whereas …

Sleep-Wake Patterns Are Altered With Age, Prdm13 Signaling In The Dmh, And Diet Restriction In Mice, Shogo Tsuji, Cynthia S Brace, Nicholas Rensing, Michael Wong, Shin-Ichiro Imai, Et Al.

2020-Current year OA Pubs

Old animals display significant alterations in sleep-wake patterns such as increases in sleep fragmentation and sleep propensity. Here, we demonstrated that PR-domain containing protein 13 (Prdm13)+ neurons in the dorsomedial hypothalamus (DMH) are activated during sleep deprivation (SD) in young mice but not in old mice. Chemogenetic inhibition of Prdm13+ neurons in the DMH in young mice promotes increase in sleep attempts during SD, suggesting its involvement in sleep control. Furthermore, DMH-specific

Using The Instrumented Sway System (Isway) To Identify And Compare Balance Domain Deficits In People With Multiple Sclerosis, Patrick G. Monaghan, Andrew S. Monaghan, Andrew Hooyman, Brett W. Fling, Jessie M. Huisinga, Daniel S. Peterson

Physical Therapy Faculty Articles and Research

Objective
To develop a multiple sclerosis (MS)-specific model of balance and examine differences between (1) MS and neurotypical controls and (2) people with MS (PwMS) with (MS-F) and without a fall history (MS-NF).

Design and Setting
A cross-sectional study was conducted at the Gait and Balance Laboratory at the University of Kansas Medical Center. Balance was measured from the instrumented sway system (ISway) assessment.

Participants
In total, 118 people with relapsing-remitting MS (MS-F=39; MS-NF=79) and 46 age-matched neurotypical controls.

Intervention
Not applicable.

Outcome Measures
A total of 22 sway measures obtained from the ISway were entered into an exploratory factor …

A Structured Life Review Intervention To Improve Life Satisfaction In Home Health Service Patients: A Feasibility Study, Leah Graf

University Scholar Projects

Two million older adults in the U.S. suffer with depression. Adults who live with the difficulties of depression concurrently experience dissatisfaction with life. Life review is a systematic recollection of past events. Dr. Robert Butler postulated that, as the elderly and those with terminal illness approach the end of their lives, there is a resurgence of life experiences in the conscience (1963). A successful life review conducted by an active listener assists the individual to process unresolved conflicts and attain ego-integrity in the final stage of life. Home health services have become an increasingly accepted option for managing chronic illnesses …

Kearns-Sayre Syndrome: Two Case Reports And A Review For The Primary Care Physician., Chad Richmond, Leonard Powell, Zachary D. Brittingham, Alison Mancuso

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Kearns-Sayre syndrome (KSS) is a mitochondrial encephalopathic disorder. Because mitochondria are ubiquitous organelles that are present in almost every human tissue, their dysfunction can affect nearly any organ system and give rise to a wide range of clinical characteristics. 1: As is the case with most diseases associated with mitochondrial DNA (mtDNA) mutations, the clinical features of KSS were defined before modern molecular genetic classifications emerged. 2: The exact prevalence of KSS is unknown; however, estimates place it at about 1:100,000 people. Although it is a rather rare syndrome, the ability to recognize or consider KSS as part of a …

Disability Advocates Of Kent County (Dakc) Consumer Follow-Up For Aging In Place, Bianca Cordova

Capstone Projects

Disability Advocates of Kent County (DAKC) is a non-profit organization with an occupational therapy (OT) department that aims to keep primarily community-dwelling, low-income, older adults safe and independent in their home. The organization provides home assessments which identifies the barriers and supports for daily activities within the home. After the home assessment evaluation, adaptive equipment and/or home modification recommendations are provided. Literature supports the restorative approach DAKC uses to facilitate aging in place. There was a lack of quantitative and qualitative evidence on how consumers were aging in place post-intervention. This capstone project focused on creating a pilot follow-up program …

Effects Of Coordinated Reset Deep Brain Stimulation Of Subthalamic Nucleus On Parkinsonian Gait In The Non-Human Primate Model, Kanon Nakajima

Neuroscience Honors Projects

Parkinson’s Disease (PD) is a neurodegenerative disorder that affects over 10 million people worldwide. Deep Brain Stimulation (DBS) has been a successful treatment for advanced PD, however, can be accompanied with current spread related side effects. Coordinated Reset (CR) DBS is a novel therapeutic approach that could reduce the risk of side-effects by using lower current. Previous research has shown therapeutic effects of CR DBS on PD motor symptoms including akinesia, bradykinesia, rigidity, and tremor that sustained after stimulation cessation (i.e., carryover effect), however its effect on gait dysfunction is unknown even though it can be one of the most …

Implementasi Kebijakan Bantuan Pangan Non Tunai Dalam Rangka Pengatasan Kemiskinan Di Era Covid - 19, Haura Ariesta, Fentiny Nugroho

Jurnal Ilmu Kesejahteraan Sosial

This study focuses on the implementation of the Non-Cash Food Assistance (BPNT) policy in poverty alleviation efforts in Kembangan District, West Jakarta, during the COVID-19 pandemic. While the BPNT program managed by the Ministry of Social Affairs of the Republic of Indonesia adheres to the distribution procedures, several challenges have emerged, including delays in disbursing aid funds, invalid beneficiary data, issues with E-waroeng (food stalls), account registration, delayed distribution, and occasional inadequacy of food supplies. However, supportive factors such as effective coordination, improved data management, education, active participation from local authorities, and the commitment of E-waroeng owners have contributed to …

Desa Wisata Atau Wisata Desa:Menelaah Fase Kesepian Masyarakat Pasca Pandemi Covid -19, Maureen Wanda Sabrina, Kania Saraswati Harisoesyanti

Jurnal Ilmu Kesejahteraan Sosial

The Tourism Village Policy launched by the government has developed into an ambitious initiative that can boost the community's economy. However, behind this dream, there is a complex discussion about how ready the village community is to undertake this transformation. This article discusses the stages of the community undergoing the tourism village program against the background of Taraju Village having limited access, the existence of newly formed supporting community self-help groups, and even the community's initial rejection of the development of a tourism village. Meanwhile, this tourist village has achieved achievements on a provincial and national scale. The research used …

Baseline Characteristics Of The North American Prodromal Synucleinopathy Cohort, Jonathan E Elliott, Jennifer Mcleland, Susan R Criswell, Yo-El S Ju, Et Al.

2020-Current year OA Pubs

OBJECTIVE: Rapid eye movement (REM) sleep behavior disorder (RBD) is widely considered a prodromal synucleinopathy, as most with RBD develop overt synucleinopathy within ~10 years. Accordingly, RBD offers an opportunity to test potential treatments at the earliest stages of synucleinopathy. The North American Prodromal Synucleinopathy (NAPS) Consortium has created a multisite RBD participant, primarily clinic-based cohort to better understand characteristics at diagnosis, and in future work, identify predictors of phenoconversion, develop synucleinopathy biomarkers, and enable early stage clinical trial enrollment.

METHODS: Participants ≥18 years of age with overnight polysomnogram-confirmed RBD without Parkinson's disease, dementia, multiple system atrophy, or narcolepsy were …

Nursing Care Of Family Caregivers: Interventions And Considerations Regarding Current Issues Facing Family Caregivers Of Persons With Dementia Relevant To Nursing Practice, Alayna Kent

Senior Honors Theses

There are an estimated 6.5 million Americans age 65 and older who are currently living with Alzheimer’s dementia. A large majority of these individuals receive care from a nonprofessional family caregiver, typically in the home setting. It is well documented that family caregivers of dementia patients experience many unique challenges. These challenges provide valuable opportunities for nurses to provide helpful interventions to aid this vulnerable population. An integrated review of the recent literature was conducted, and articles were chosen by a method modeled after the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flowsheet. The research was then analyzed …

Peran Program Pengembangan Petani Sebagai Implementasi Csr Pt. Smgp Terhadap Resistensi Masyarakat, Ahmad Taufik, Indra Lestari

Jurnal Ilmu Kesejahteraan Sosial

The presence of mining projects or power plants that utilize or exploit natural resources has the potential for environmental, social, and economic problems for the community. There are many cases of rejection from communities around the project area, which can even lead to conflict and anarchic actions that cause losses for several parties. Meanwhile, there are demands for energy sustainability amidst the current crisis in the availability of fossil energy. Therefore, the government provides support through several policies, one of which is encouraging the implementation of Corporate Social Responsibility so that core project activities can take place with attention to …

Implementasi Tahapan Pengembangan Masyarakat Dalam Program Perhutanan Sosial, Ahmad Nur Faizal, Moch. Ilham Noer Sunan

Jurnal Ilmu Kesejahteraan Sosial

The community's dependence on the forest makes the community's position vulnerable when access to the forest is restricted. The restrictions on community access to forests impact on emerging social problems such as poverty, conflict, and illegal logging. Responding to this problem, the government rolled out a social forestry program to improve people's lives. This research uses a qualitative approach with data collection techniques through observation, semi-structured interviews, and documentation to study in depth how the community development stages are implemented in the social forestry program in Burno Village. The results showed that there were community development efforts from CDK Lumajang …

Model Perencanaan Strategis Dalam Service Organization : Sebuah Kajian Literatur, Rakhmiana, Johanna Debora Imelda

Jurnal Ilmu Kesejahteraan Sosial

In Indonesia, several types of HSOs include government organizations, private organizations, and non-profit organizations. Strategic planning is crucial for HSOs as it helps them to map their direction and goals, manage their resources, identify opportunities and challenges, coordinate their activities, and measure and evaluate their performance. To assist in strategic planning, various mapping models can be used. One of the models that can be used is Scenario- Based Road Mapping (SBRM). This research is a literature review that discusses different strategic planning models for HSOs, which can help organizations formulate more effective and adaptive strategies. These models can help HSOs …

Multimorbidity In Diverse Populations: Stratified Analysis Of Race/Ethnicity, Age, Obesity, And Healthcare Costs, Manal Alshakhs

Theses and Dissertations (ETD)

This research aims to fill an essential gap in understanding how Body Mass Index (BMI) cutoffs relate to multimorbidity across races in the United States (US). Given the significant and growing rates of obesity and multimorbidity, as well as the known differences in healthy fat distribution among different races, this is an important area of research. BMI is a widely used but imperfect measure of obesity, as it does not account for differences in body composition. However, it is still used as a diagnostic tool. It is vital to ensure that the cutoffs used to define obesity are appropriate for …

Plasma Metabolites Associated With Cognitive Function Across Race/Ethnicities Affirming The Importance Of Healthy Nutrition, Einat Granot-Hershkovitz, Shan He, Jan Bressler, Bing Yu, Wassim Tarraf, Casey M Rebholz, Jianwen Cai, Queenie Chan, Tanya P Garcia, Thomas Mosley, Bruce S Kristal, Charles Decarli, Myriam Fornage, Guo-Chong Chen, Qibin Qi, Robert Kaplan, Hector M González, Tamar Sofer

Faculty, Staff and Student Publications

INTRODUCTION: We studied the replication and generalization of previously identified metabolites potentially associated with global cognitive function in multiple race/ethnicities and assessed the contribution of diet to these associations.

METHODS: We tested metabolite-cognitive function associations in U.S.A. Hispanic/Latino adults (n = 2222) from the Community Health Study/ Study of Latinos (HCHS/SOL) and in European (n = 1365) and African (n = 478) Americans from the Atherosclerosis Risk In Communities (ARIC) Study. We applied Mendelian Randomization (MR) analyses to assess causal associations between the metabolites and cognitive function and between Mediterranean diet and cognitive function.

RESULTS: Six metabolites were consistently associated …

Oral Health Considerations For Aging Patients Living With Hiv/Aids, Madeleine Daily Dds, Susan Liu Dds, Yuna Park Dds, Mph, Ms, Emily Byington Msw, Ivette Estrada Ma, Mphil, Sunil Wadhwa Dds, Carol Kunzel Phd

The New York State Dental Journal

People living with HIV/AIDS (PLWH) have an increased life expectancy due to advances in antiretroviral therapy. In 1996, the life expectancy for a 20-year old living with HIV was 39-years old; today, it is >70-years old. As life expectancy increases, PLWH are burdened with age-associated comorbidities. This paper reviews the interaction between aging and HIV and how it affects social, physical, and oral health issues. The shift in demographics presents new challenges for clinicians in how to identify, address, and manage these complex manifestations. This review summarizes how to approach HIV-related changes when providing care as a dental clinician.

Resident Reported Changes To Social Engagement And Quality Of Life Due To Increased Physical Activity Within A Senior Living Facility, Sydney Leroy

Capstone Projects

The purpose of this Doctoral Capstone Experience (DCE) was to see if regular participation in an exercise program could promote positive changes in social engagement and overall quality of life for older adults residing in an independent or assisted living facility. A standardized assessment and interview were completed with each participating resident before and after a 6-week exercise program to assess any changes in social engagement and quality of life. As a result, recruitment for this study and overall resident participation increased by advertising new and existing exercise classes throughout the senior living facility. In addition to the already scheduled …

Exploration Of Driving Rehabilitation Best Practices To Sustain An Occupation Focused Driver Rehabilitation Program, Kelsey East

Capstone Projects

In the United States driving dominates as the primary mode of transportation connecting people to resources including work, school, stores, and hospitals. Driving enables individuals to participate in the occupations they need or want to do, which is why it is a critical Instrumental Activity of Daily Living (IADL). Because driving falls within an occupational therapist’s scope of community mobility, many driving rehabilitation specialists have a background in occupational therapy. Driving rehabilitation is an expanding practice area, with emerging evidence supporting the use of an IADL based assessment for determining fitness to drive. Therefore, the main goal of this doctoral …

Altered Lateralization Of The Cingulum In Deployment-Related Traumatic Brain Injury: An Enigma Military-Relevant Brain Injury Study, Emily L Dennis, Mary R Newsome, Hannah M Lindsey, Maheen Adamson, Tara A Austin, Seth G Disner, Blessen C Eapen, Carrie Esopenko, Carol E Franz, Elbert Geuze, Courtney Haswell, Sidney R Hinds, Cooper B Hodges, Andrei Irimia, Kimbra Kenney, Inga K Koerte, William S Kremen, Harvey S Levin, Rajendra A Morey, John Ollinger, Jared A Rowland, Randall S Scheibel, Martha E Shenton, Danielle R Sullivan, Leah D Talbert, Sophia I Thomopoulos, Maya Troyanskaya, William C Walker, Xin Wang, Ashley L Ware, John Kent Werner, Wright Williams, Paul M Thompson, David F Tate, Elisabeth A Wilde

Faculty, Staff and Students Publications

Traumatic brain injury (TBI) in military populations can cause disruptions in brain structure and function, along with cognitive and psychological dysfunction. Diffusion magnetic resonance imaging (dMRI) can detect alterations in white matter (WM) microstructure, but few studies have examined brain asymmetry. Examining asymmetry in large samples may increase sensitivity to detect heterogeneous areas of WM alteration in mild TBI. Through the Enhancing Neuroimaging Genetics Through Meta-Analysis Military-Relevant Brain Injury working group, we conducted a mega-analysis of neuroimaging and clinical data from 16 cohorts of Active Duty Service Members and Veterans (n = 2598). dMRI data were processed together along with …

Pilot Clinical Trial Of Macimorelin To Assess Safety And Efficacy In Patients With Cancer Cachexia, Megan Herodes, Lindsey J Anderson, Samuel Shober, Ellen A Schur, Solomon A Graf, Nicola Ammer, Ramiro Salas, Marco Marcelli, Jose M Garcia

Faculty, Staff and Students Publications

BACKGROUND: Cancer cachexia is associated with reduced body weight, appetite and quality of life (QOL) with no approved treatments. Growth hormone secretagogues like macimorelin have potential to mitigate these effects.

METHODS: This pilot study assessed the safety and efficacy of macimorelin for 1 week. Efficacy was defined a priori as 1-week change in body weight (≥0.8 kg), plasma insulin-like growth factor (IGF)-1 (≥50 ng/mL) or QOL (≥15%). Secondary outcomes included food intake, appetite, functional performance, energy expenditure and safety laboratory parameters. Patients with cancer cachexia were randomized to 0.5 or 1.0 mg/kg macimorelin or placebo; outcomes were assessed non-parametrically.

RESULTS: …

Emotional, Behavioral, And Physical Health Consequences Of Loneliness In Young Adult Survivors Of Childhood Cancer: Results From The Childhood Cancer Survivor Study, Chiara Papini, Ameera A Fayad, Mingjuan Wang, Fiona S M Schulte, I-Chan Huang, Yu-Ping Chang, Rebecca M Howell, Deokumar Srivastava, Wendy M Leisenring, Gregory T Armstrong, Todd M Gibson, Leslie L Robison, Kevin C Oeffinger, Kevin R Krull, Tara M Brinkman

Faculty, Staff and Student Publications

Background: Young adults in the general population are at risk of experiencing loneliness, which has been associated with physical and mental health morbidities. The prevalence and consequences of loneliness in young adult survivors of childhood cancer remain unknown.

Methods: A total of 9664 young adult survivors of childhood cancer (median age at diagnosis 10.5 years [interquartile range (IQR), 5-15], 27.1 years at baseline [IQR, 23-32]) and 2221 siblings enrolled in the Childhood Cancer Survivor Study completed a self-reported survey question assessing loneliness on the Brief Symptom Inventory-18 at baseline and follow-up (median follow-up, 6.6 years). Multivariable models evaluated the prevalence …