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The Relationships Among Proprioception, Balance, And Cognitive Perception Of Body Awareness In College Students, Courtney Helmick

Honors College Theses

Introduction: Proprioception is an important physiological function that is essential for activities of daily living as well as exercise and sport performance. Integration of proprioceptive signals plays a key role in both static and dynamic balance. Previously, researchers have assessed the relationship between balance and proprioception, however, the effect of cognitive perception of body awareness has not previously been included in this research. The aim of this pilot study was to explore the relationships among lower extremity proprioception, dynamic balance, and cognitive perception of body awareness in college students.

Methods: Nineteen apparently healthy college students (age 21.26 ± 1.10 years, …

The Impact Of Low Appendicular Skeletal Muscle Mass In The Development Of Insulin Resistance And Metabolic Syndrome: A Systematic Review Of The Literature, Ella Boston

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Chronic conditions are the leading cause of death and disability. More specifically, cardio-metabolic disease is the number one cause of death worldwide. The tragedy and burden of disease is unrefuted; even more so, evidence indicates that realistic modifications of lifestyle can prevent most chronic disease. Metabolic syndrome and insulin resistance are leading risk factors in the development of cardio-metabolic disease. Presently, chronic disease is treated through symptomatic evaluation of risk. Reframing the lens of care through root cause evaluation is fundamental to optimizing patient outcomes. The purpose of this systematic review is to synthesize literature evaluating the impact of low …

The Psychometric Properties Of The Modified Fear Of Falling Avoidance Behavior Questionnaire In Parkinson’S Disease And Older Adults, Billy La, Arturo Aldaco, Ashley Haller

UNLV Theses, Dissertations, Professional Papers, and Capstones

Background/purpose: The Fear of Falling Avoidance Behavior Questionnaire (FFABQ), developed in 2011 to measure fear of falling avoidance behavior, has good evidence for reliability and validity. However, a recently modified version (mFFABQ) is theorized to be easier to understand for those completing the questionnaire because the Likert responses are more logical in completing the item stem. The purpose of this study was to examine the test-retest reliability and construct validity of the mFFABQ in adults with Parkinson’s Disease (PD) and older adults aged 60-90 years. Methods: Thirty-nine participants (age 72.21 ± 9.5; 29 men, 10 women) diagnosed with PD (diagnosis …

Stepping On - Virtual Fall Prevention For Older Adults, Sean Conners, Tyler Greener, Kaitlyn Johnson

UNLV Theses, Dissertations, Professional Papers, and Capstones

Three student learners in a doctoral physical therapy program completed a service-based learning project dedicated to reducing falls in the elderly. The program, called Stepping On, is a fall prevention initiative supported by the Wisconsin Institute for Healthy Aging (WIHA) whose goal is to identify risk factors for falls in the older population and provide exercises and recommendations to reduce falls. The eleven volunteer participants in this student learners’ Stepping On program completed online fall prevention classes and provided feedback at the completion of the program. Participants reported being more conscientious while walking and noted improved balance and flexibility.

Evaluation Of A Care Management Program On Family Caregivers Of Persons With Dementia, Victoria L. Jackson

Doctoral Projects

Dementia due to Alzheimer’s and other disease is a growing concern for healthcare providers as the number of individuals in the U.S. population ages. Persons with dementia (PWDs) rely on caregivers, primarily family caregivers (FCGs), for basic and instrumental activities of daily living as the disease progresses. There may be negative outcomes, such as depression, strain, and distress for FCGs of PWDs. Routine assessment and intervention by healthcare providers can address needs of FCGs of PWDs. There are multiple interventions that have demonstrated effectiveness in caring for PWDs and FCGs; one such intervention is care management. The University of California, …

Nicotinamide Riboside And Beta-Hydroxybutyrate Activate Parallel Pathways For C. Elegans Lifespan Extension, Mckenzie Peters

Undergraduate Honors Theses

Supplementation with nicotinamide riboside (NR), a form of vitamin B3 and a precursor of nicotinamide adenine dinucleotide (NAD⁺) extends lifespan in the nematode C. elegans and delays aging-related pathologies in mammals. During aging, levels of NAD⁺ decline causing metabolic dysfunction and oxidative damage. Studies in C. elegans found that when NR was administered during larval development it induced the mitochondrial unfolded protein response (UPR^mt), which is frequently associated with lifespan extension. Both calorie restriction (CR) and ketogenic diets (KD) have been shown to extend lifespan, in part through increasing NAD⁺ and through increasing levels …

Effects Of Time Restricted Feeding And Whey Protein Isolate Supplementation On Dietary Intake, Mood, And Sleep In A 12-Week Randomized Controlled Trial, Sydney Boudrey

Human Nutrition and Hospitality Management Undergraduate Honors Theses

Background: Obesity is a quickly growing epidemic that is affecting adults in the United States leading to many chronic diseases and reduced well-being. Time Restricted Feeding (TRF) is type of dietary intervention that is gaining popularity among adults for weight loss. However, current data is lacking regarding the effectiveness of TRF on facets of well-being such as sleep and mood. Moreover, to our knowledge protein supplementation in conjunction with TRF has yet to be studied. The objective of this study was to determine the effect of time restricted feeding supplemented with whey protein isolate on food intake, sleep, and mood, …

Recognizing Barriers In The Elderly Population And Increasing Access To Case Management Services, Loveleena Alex

Doctor of Nursing Practice Projects

Abstract

Implementing case management can lead to fewer hospitalizations in the elderly population. Barriers influencing the number of hospitalizations include low socioeconomic status, transportation needs, health literacy, financial strain, multiple comorbidities, underserved populations, medication availability, availability of community resources, and access to primary care. A review of the available literature revealed that by addressing these barriers in a primary care setting and implementing case management, the number of hospitalizations can be decreased and the quality of life in the elderly population can be improved. This quality improvement project implemented a screening and referral process for chronic care management in the …

Ots Delivering Culturally Sensitive Care For Dementia Family Caregivers From Diverse Backgrounds, Abraham Lai, Lucy Palacios Mendez, Darren Sarmiento

Occupational Therapy | MSOT Capstone Projects

As occupational therapists, addressing key cultural barriers that may obstruct access to dementia care and education for individuals with dementia and their caregivers from diverse backgrounds is a priority for client-centered care. Stress, racial discrimination, and distrust may exacerbate symptoms and prevalence of dementia in certain populations, such as Chinese- Americans and Latinx (Quinones et al. 2020). Immigrants’ experiences of aging and health are diverse due to belonging to different socioeconomic, ethnic, cultural, and linguistic groups and having varying levels of education and work experience (R. S. 2020). There are existing cultural differences regarding caregiving and family networks, perception and …

Effects Of A 12-Week Remote Exercise Program On Balance In Adults With Down Syndrome, Kayla Kotake, Sherwin Cadiao, Nicole Kaes, Jayston Prudencio

UNLV Theses, Dissertations, Professional Papers, and Capstones

Purpose/Hypothesis Individuals with Down syndrome (Ds) tend to have deficits in balance and postural control, which negatively affects their ability to perform physical activities safely and independently. Previous research has shown that exercise can improve balance in people with Ds, however, most studies looked at balance in children with Ds. As the average life expectancy for people with Ds has increased, there is a need for research investigating balance in adults with Ds. Also, there is a need to increase exercise opportunities (eg, remote exercise programs) for adults with Ds, as physical inactivity and sedentary behavior are prevalent among individuals …

The Effects Of Telehealth On Access To Palliative Care In Rural Communities, Ryleigh Hanson

Honors Program: Senior Projects (Public)

Patients with serious and life-limiting illnesses are in need of palliative care which allows for both the patient and their family to learn how to live a relatively quality life in spite of their illness. Current access to palliative care is limited to urban areas leaving those in rural communities to face their illness without proper care. To understand why these limitations exist and to determine possible solutions, several articles were analyzed that focused on the benefits and stigmas of palliative care, why rural communities struggle to gain access to palliative care, and if telehealth is a possible solution to …

Promoting Early Detection In Primary Care: Program Evaluation Of The Dementia Care Aware Program In Orange County, Ennah Cabading

UNLV Theses, Dissertations, Professional Papers, and Capstones

The aging population is growing quickly, raising concerns about the increasing numbers of those with Alzheimer's disease and related dementias, as age is the common risk factor for acquiring the disease. The increase in the elderly population may influence higher healthcare costs and the need for more healthcare professionals like primary care professionals. However, primary care professionals face challenges meeting this population's demands due to the lack of training, confidence, and understanding of dementia care. A new California initiative called Dementia Care Aware aims to support primary care professionals by offering training, tools, and resources to increase early detection and …

Prefrontal Activation During Inhibition Of A Balance Recovery Step, Ezinne Abugu

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

The ability to quickly step is an important strategy to avoid a fall. However, real-world settings often constrain a stepping path. Such constraints necessitate response inhibition to prevent an inappropriate step and select a new course of action to ultimately recover balance. The present study investigated neural mechanisms that underlie this ability to stop a highly automatic balance recovery step. In the field of cognitive neuroscience, response inhibition has typically been researched using focal hand reaction tasks performed by seated participants. This approach combined with neuroimaging has revealed a neural stopping network, which includes the right Inferior Frontal Gyrus (right …

Gender, Personality, And Cognitive Resilience Against Early-Life Disadvantage, Joseph L. Saenz, Sadaf Arefi Milani, Silvia Mejia-Arango

School of Medicine Publications

Objectives: Early-life disadvantage (ELD) relates to lower late-life cognition. However, personality factors, including having an internal locus of control (LOC) or a conscientious personality, relate to resilience and effective stress coping. We explore whether personality factors convey resilience against the negative effects of ELD on cognition, by gender, in Mexico.

Methods: Using the 2015 Mexican Health and Aging Study, we estimated expected cognition using multiple ELD markers to identify a subsample in the lowest quartile of expected cognition given ELD (n = 2,086). In this subsample, we estimated cross-sectional associations between personality and having above-median observed cognitive ability (n = …

Genome-Wide Analysis Of Structural Variants In Parkinson Disease, Kimberley J Billingsley, Jinhui Ding, Pilar Alvarez Jerez, Anastasia Illarionova, Kristin Levine, Francis P Grenn, Mary B Makarious, Anni Moore, Daniel Vitale, Xylena Reed, Dena Hernandez, Ali Torkamani, Mina Ryten, John Hardy, Uk Brain Expression Consortium (Ukbec), Ruth Chia, Sonja W Scholz, Bryan J Traynor, Clifton L Dalgard, Debra J Ehrlich, Toshiko Tanaka, Luigi Ferrucci, Thomas G Beach, Geidy E Serrano, John P Quinn, Vivien J Bubb, Ryan L Collins, Xuefang Zhao, Mark Walker, Emma Pierce-Hoffman, Harrison Brand, Michael E Talkowski, Bradford Casey, Mark R Cookson, Androo Markham, Mike A Nalls, Medhat Mahmoud, Fritz J Sedlazeck, Cornelis Blauwendraat, J Raphael Gibbs, Andrew B Singleton

Faculty, Staff and Students Publications

OBJECTIVE: Identification of genetic risk factors for Parkinson disease (PD) has to date been primarily limited to the study of single nucleotide variants, which only represent a small fraction of the genetic variation in the human genome. Consequently, causal variants for most PD risk are not known. Here we focused on structural variants (SVs), which represent a major source of genetic variation in the human genome. We aimed to discover SVs associated with PD risk by performing the first large-scale characterization of SVs in PD.

METHODS: We leveraged a recently developed computational pipeline to detect and genotype SVs from 7,772 …

Genetic Associations Between Modifiable Risk Factors And Alzheimer Disease, Jiao Luo, Jesper Qvist Thomassen, Céline Bellenguez, Benjamin Grenier-Boley, Itziar De Rojas, Atahualpa Castillo, Kayenat Parveen, Fahri Küçükali, Aude Nicolas, Oliver Peters, Anja Schneider, Martin Dichgans, Dan Rujescu, Norbert Scherbaum, Deckert Jürgen, Steffi Riedel-Heller, Lucrezia Hausner, Laura Molina Porcel, Emrah Düzel, Timo Grimmer, Jens Wiltfang, Stefanie Heilmann-Heimbach, Susanne Moebus, Thomas Tegos, Nikolaos Scarmeas, Jordi Clarimon, Fermin Moreno, Jordi Pérez-Tur, María J Bullido, Pau Pastor, Raquel Sánchez-Valle, Victoria Álvarez, Mercè Boada, Pablo García-González, Raquel Puerta, Pablo Mir, Luis M Real, Gerard Piñol-Ripoll, Jose María García-Alberca, Jose Luís Royo, Eloy Rodriguez-Rodriguez, Hilkka Soininen, Teemu Kuulasmaa, Alexandre De Mendonça, Shima Mehrabian, Jakub Hort, Martin Vyhnalek, Sven Van Der Lee, Caroline Graff, Goran Papenberg, Vilmantas Giedraitis, Anne Boland, Delphine Bacq-Daian, Jean-François Deleuze, Gael Nicolas, Carole Dufouil, Florence Pasquier, Olivier Hanon, Stéphanie Debette, Edna Grünblatt, Julius Popp, Luisa Benussi, Daniela Galimberti, Beatrice Arosio, Patrizia Mecocci, Vincenzo Solfrizzi, Lucilla Parnetti, Alessio Squassina, Lucio Tremolizzo, Barbara Borroni, Benedetta Nacmias, Sandro Sorbi, Paolo Caffarra, Davide Seripa, Innocenzo Rainero, Antonio Daniele, Carlo Masullo, Gianfranco Spalletta, Julie Williams, Philippe Amouyel, Frank Jessen, Patrick Kehoe, Magda Tsolaki, Giacomina Rossi, Pascual Sánchez-Juan, Kristel Sleegers, Martin Ingelsson, Ole A Andreassen, Mikko Hiltunen, Cornelia Van Duijn, Rebecca Sims, Wiesje Van Der Flier, Agustín Ruiz, Alfredo Ramirez, Jean-Charles Lambert, Ruth Frikke-Schmidt

Faculty, Staff and Students Publications

IMPORTANCE: An estimated 40% of dementia is potentially preventable by modifying 12 risk factors throughout the life course. However, robust evidence for most of these risk factors is lacking. Effective interventions should target risk factors in the causal pathway to dementia.

OBJECTIVE: To comprehensively disentangle potentially causal aspects of modifiable risk factors for Alzheimer disease (AD) to inspire new drug targeting and improved prevention.

DESIGN, SETTING, AND PARTICIPANTS: This genetic association study was conducted using 2-sample univariable and multivariable mendelian randomization. Independent genetic variants associated with modifiable risk factors were selected as instrumental variables from genomic consortia. Outcome data for …

A Center Experience With Common Data Elements In Chronic Illness Self-Management Research, Wendy S. Bauer, Rachel F. Schiffman

College of Nursing Faculty Research and Publications

In recent decades, the use of common data elements has expanded across the health disciplines. This has included growth within programs of research focused on self-management and family nursing. Family nursing and self-management science may be expanded with the increased use of common concepts, measures, and theoretical frameworks. This article describes the experience of exploring the use of common data elements and identifying shared concepts from the perspective of one National Institute of Nursing Research funded Exploratory Center in Self-Management. Guidance offered by the Individual and Family Self-Management Theory is discussed, and implications for family research are presented.

Cardiovascular Disease, Muscle Function, And Long-Term Falls Risk: The Perth Longitudinal Study Of Ageing Women, Abadi K. Gebre, Marc Sim, Jack Dalla Via, Alexander J. Rodríguez, Kun Zhu, John T. Schousboe, Jonathan M. Hodgson, Catherine P. Bondonno, Richard L. Prince, Joshua R. Lewis

Research outputs 2022 to 2026

Background: A few cross-sectional studies have highlighted inconsistent associations between cardiovascular disease (CVD) and musculoskeletal conditions. We sought to investigate the relationship between clinical CVD including subtypes, compromised muscle function, as well as incident self-reported and injurious falls in older women. Materials and methods: 1431 community-dwelling older women (mean age ± SD; 75.2 ± 2.7 years) were included in over 14.5 years of a prospective study, the Perth Longitudinal Study of Ageing in Women. CVD (up to 18-years prior to the baseline visit) and injurious fall hospitalizations over 14.5 years were obtained from linked health records. Self-reported falls for five …

Genetic Loci Of Beta-Aminoisobutyric Acid Are Associated With Aging-Related Mild Cognitive Impairment, Einat Granot-Hershkovitz, Brian Spitzer, Yunju Yang, Wassim Tarraf, Bing Yu, Eric Boerwinkle, Myriam Fornage, Thomas H Mosley, Charles Decarli, Bruce S Kristal, Hector M González, Tamar Sofer

Faculty, Staff and Student Publications

We studied the genetic associations of a previously developed Metabolomic Risk Score (MRS) for Mild Cognitive Impairment (MCI) and beta-aminoisobutyric acid metabolite (BAIBA)-the metabolite highlighted by results from a genome-wide association study (GWAS) of the MCI-MRS, and assessed their association with MCI in datasets of diverse race/ethnicities. We first performed a GWAS for the MCI-MRS and BAIBA, in Hispanic/Latino adults (n = 3890) from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). We identified ten independent genome-wide significant (p value <5 × 10-8) variants associated with MCI-MRS or BAIBA. Variants associated with the MCI-MRS are located in the Alanine-Glyoxylate Aminotransferase 2 (AGXT2 gene), which is known to be associated with BAIBA metabolism. Variants associated with BAIBA are located in the AGXT2 gene and in the SLC6A13 gene. Next, we tested the variants' association with MCI in independent datasets of n = 3178 HCHS/SOL older individuals, n = 3775 European Americans, and n = 1032 African Americans from the Atherosclerosis Risk In Communities (ARIC) study. Variants were considered associated with MCI if their p value <0.05 in the meta-analysis of the three datasets and their direction of association was consistent with expectation. Rs16899972 and rs37369 from the AGXT2 region were associated with MCI. Mediation analysis supported the mediation effect of BAIBA between the two genetic variants and MCI (p value = 0.004 for causal mediated effect). In summary, genetic variants in the AGXT2 region are associated with MCI in Hispanic/Latino, African, and European American populations in the USA, and their effect is likely mediated by changes in BAIBA levels.

Understanding The Experiences Lived By Nurses Caring For Patients With Covid-19: A Hermeneutic Approach, Awatif Mansoor Alrasheeday, Ma. Venus Borja, Eddieson Pasay-An, Farhan Alshammari

Makara Journal of Health Research

Background: Nursing is highlighted among professions that value caring and is perceived as the profession’s heart and soul because of its critical role in providing and delivering high-quality patient care, especially during this coronavirus disease 2019 (COVID-19) pandemic. However, little is understood about the experiences of the frontline workers in caring for persons diagnosed with COVID-19. This study aimed to explore the experiences of nurses in caring for persons diagnosed with COVID-19 inspired by the four lived worlds of van Manen.

Methods: The hermeneutic phenomenology was used in nine nurses working in hospitals of Hail region. This study …

Focusing Our Attention On Socially Responsive Professional Education To Serve Ethnogeriatric Populations With Neurogenic Communication Disorders In The United States, José G. Centeno, Loraine K. Obler, Linda Collins, Gloriajean Wallace, Valarie B. Fleming, Jacqueline Guendouzi

Communication Sciences and Disorders Faculty Articles and Research

Purpose:

This viewpoint discusses a plausible framework to educate future speech-language pathologists (SLPs) as socially responsive practitioners who serve and advocate for the burgeoning vulnerable ethnogeriatric populations with neurogenic communication disorders.

Method:

We provide an overview of the demographic, epidemiological, and biopsychosocial context that supports the implementation of equity-based, population-grounded educational approaches for speech-language pathology services in ethnogeriatric neurorehabilitation caseloads and discuss a plausible perspective based on the educational social determinants of health (SDOH) framework by the National Academies of Sciences, Engineering, and Medicine.

Results:

The NASEM's three-domain SDOH educational perspective integrates education, community, and organization to create a self-reinforcing …

45 Senolytic Therapy Transiently Reduces Inflammatory Markers In Primary Blood Mononuclear Cells Of Individuals With Early Alzheimer’S Disease: Exploring The Conserved Transcriptional Response To Adversity As A Biomarker For Disease State, Valentina R. Garbarino, Peng Xu, Bin Zhang, Mitzi M. Gonzales, Miranda E. Orr

School of Medicine Publications

OBJECTIVES/GOALS: Determine if the Conserved Transcriptional Response to Adversity transcriptomic profile established in primary blood mononuclear cells (PBMC) of chronically stress caregivers, is present in individuals with early Alzheimer’s disease. Chronic stress is a risk factor for Alzheimer’s, and may be an untapped biomarker for disease risk and pathology.

METHODS/STUDY POPULATION: To collect preliminary data on the Conserved Transcriptional Response to Adversity profile in individuals with Alzheimer’s disease, we were able to utilize primary blood mononuclear cell samples from a small open label pilot study called Senolytic Therapy to Modulate the Progression of Alzheimer’s Disease, designed to clear stressed senescent …

Virtual Visits In Routine Prenatal Care, Katrina K. Wu

MUSC Theses and Dissertations

Problem

One million pregnant persons in the United States do not receive early prenatal care or the recommended number of prenatal visits each year, and this gap in care access disproportionately affects people of color, those with lower incomes, and those living in rural communities. Telemedicine was widely utilized in prenatal care during the COVID-19 pandemic, and optimizing prenatal telemedicine has the potential to improve prenatal care access beyond the pandemic.

Purpose

This dissertation focused on examining the integration of virtual visits in routine prenatal care during the COVID-19 pandemic. The purpose of this dissertation was to:

Aim 1. Explore …

Building Before: Community Resiliency As Emergency Management, Alexandria Rinne

Honors Program: Senior Projects (Public)

This project seeks to address gaps in emergency preparedness education related to tornado response. Through an examination of current research about best practices for tornado emergency management response and an examination of the needs of FEMA Regions 7 and 8, the author has identified key strategies and stakeholders to increase positive outcome through building community engagement and resiliency. Three presentations were created for delivery to key community stakeholders—local government officials; non-governmental organizations, social networks, and associations; and individual private citizens. The project offers an overview of background research and provides presentation slide decks, scripts, and discussion guides, all created with …

Design Considerations Of The Aged As It Is Applied To Senior Housing, Amanda Mcnally

Liberty University Research Week

Undergraduate

Applied

Combating Long-Term Care Isolation Through Healing Touch, Veronica J. Butts

ONU Student Research Colloquium

Loneliness is defined as feelings of disconnectedness, lack of belonging, and perceived isolation that can manifest as a physical or psychological state. In long-term care facilities, this sentiment can develop into social isolation in which residents are disconnected from family, removed from familiar environments, and suffer from various cognitive conditions that cause them to socially withdraw. Various clinical studies seek to identify the connection between isolation, loneliness, and lack of human touch with worsening health conditions and outcomes, determining that there is a correlation between this feeling of discontent. To combat this, healing touch has been a rising topic of …

What Can I Do? A Response To The Vulnerable Elderly, Josephine Camiola

Liberty University Research Week

Undergraduate

Theoretical Proposal

Limited English Proficiency: Addressing The Challenges To Health Care Workers, Adrianna Rought

Liberty University Research Week

Undergraduate

Theoretical Proposal

The Effects Of Verbal Fluency Interventions: Phonemic Versus Semantic Fluency Outcomes In Parkinson’S Disease, Brian Connelly

Student Academic Conference

•Relevant Literature and Background –Verbal Fluency Tasks –Parkinson’s Disease •Practice Activity –Phonemic and Semantic Trials •Discussion of the Study –Methods –Results –Discussion

The Relationship Of Trait-Like Compassion With Epigenetic Aging: The Population-Based Prospective Young Finns Study, Henrik Dobewall, Liisa Keltikangas-Järvinen, Saara Marttila, Pashupati P. Mishra, Aino Saarinen, C. Robert Cloninger, Igor Zwir, Mika Kähönen, Mikko Hurme, Olli Raitakari, Terho Lehtimäki, Mirka Hintsanen

School of Medicine Publications

Introduction: Helping others within and beyond the family has been related to living a healthy and long life. Compassion is a prosocial personality trait characterized by concern for another person who is suffering and the motivation to help. The current study examines whether epigenetic aging is a potential biological mechanism that explains the link between prosociality and longevity.

Methods: We used data from the Young Finns Study that follows six birth-cohorts from age 3–18 to 19–49. Trait-like compassion for others was measured with the Temperament and Character Inventory in the years 1997 and 2001. Epigenetic age acceleration and telomere …