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Abstract Book (Pdf), Department Of Psychiatry

Dept. of Psychiatry Research Symposium

Abstract book for the 4th Annual Department of Psychiatry Research Symposium held April 9, 2026.

Reirradiation Treatment Effects In The Clinic (Retec) Proposal - Proof Of Concept Based On Spinal Cord Dose Tolerance For Reirradiation With Stereotactic Body Radiotherapy, Jimm Grimm, Anand Mahadevan, Olusola Obayomi-Davies, Scott G. Soltys, Arjun Sahgal, Kristin J. Redmond, Michael T. Milano, Wolfgang A. Tomé, Kenneth Brooks, Scott Dodd, John Austin Vargo, Gopal Subedi, Jinyu Xue, Bisher Ebid, Felix Ehret, Byung-Han Andrew Rhieu, Christoph Fürweger, Rachel Grimm, Alexander Muacevic, Vitali Moiseenko, Shalom Kalnicki, Mark Mclaughlin, Lawrence R. Kleinberg, John R. Adler, Iris C. Gibbs

College of Health Professions Faculty Papers

BACKGROUND: Since the inception of spinal radiosurgery decades ago, the factors influencing spinal cord recovery have remained unclear. Elucidating these factors would aid in reirradiation planning and delivery. We describe modeling reirradiation normal tissue complication probabilities (NTCP) from compiled published data, akin to the collaborative Quantitative Analysis of Normal Tissue Effects in the Clinic (QUANTEC) and High Dose per Fraction, Hypofractionated Treatment Effects in the Clinic (HyTEC) projects.

PURPOSE: Simple dose-time recovery factors for the spinal cord serve as a basis to propose the Reirradiation Treatment Effects in the Clinic (ReTEC) project. ReTEC aims to define human organ recovery factors …

Connectivity, Classroom, And Contagion: An Ecological Analysis Of Testing Availability, Sex Education, And Sti Rates In The Upper Midwest, Macey M. Boerhave

Honors Thesis

Rural and frontier communities in the Upper Midwest face unique challenges that shape how young people access sexual health information and testing. While sexually transmitted infection (STI) rates continue to rise nationally, less is known about how sexual health education, digital access, and geographic distance influence these trends at a county level. This study examines the relationship between broadband internet access rates, poverty rates, proximity to free or low-cost STI testing sites, and county-level STI rates among individuals aged 15-24 in selected counties across South Dakota, North Dakota, Minnesota, Iowa, and Nebraska. Using an ecological, cross-sectional design, county-level STI surveillance …

Suena Como Nosotros: A Spanish-English Storybook For Growing Voices, Stephanie Czajka

Undergraduate Theses

The purpose of this project is to address the lack of speech therapy resources available to bilingual Spanish-English-speaking children between the ages of four to six. It will target common speech and language difficulties observed in children during the critical language development period, between the ages of four and six. This book will provide an accessible, culturally relevant speech therapy resource that can be used in the comfort of the home. Through the creation of this book, equity in healthcare access will be promoted, and bilingual pride and identity will be supported. The objectives of this project include designing and …

Exploring The Role Of Cine-Virtual Reality In Empathy And Awareness Of Social Determinants Of Health Among Occupational Therapy Students, Leah M. Stade, Madison Mckeever, Emma Gardner, Jana L. Wardian Phd

Innovations in Health Sciences Education Journal

Understanding social determinants of health (SDOH) is crucial for Occupational Therapy students to develop empathy and deliver optimal healthcare. This study explores using web-based 360° cinematic virtual reality (cine-VR) simulations in Level I fieldwork to address SDOH education and occupational engagement before community-based exposure.

This mixed methods study involved surveys and thematic analysis of written reflections from fifty students in a distance-based program at a Midwest university. Students viewed 12 web-based immersive cine-VR modules about a client experiencing multiple SDOH impacts. Surveys were conducted at baseline, post-intervention, and 6-weeks post-intervention, measuring empathy using the Jefferson Empathy Scale and attitudes toward …

Occupational Therapy And Periodontics Collaboration To Improve Hand Health And Fine Motor Skills In Dental Student, Zainab Alsuwaiyan

Master's Theses (2009 -)

Background: A study conducted in 2023 by the Occupational Therapy (OT) Department and Marquette University school of dentistry (MUsoD) demonstrated that many student participants scored below average on hand function testing, indicating a need for occupational therapy intervention. Objective: The purpose of this study was to evaluate the effectiveness of occupational therapy–led training for periodontics and registered dental hygienist faculty on the performance of dental students in the Introduction to Clinical Practice course (DEIN 7114). Methods: Faculty teaching in DEIN 7114 were recruited for this study. They participated in educational sessions led by occupational therapy faculty focusing on musculoskeletal disorders …

Development And Application Of A Multiplex Bead-Based Platform For Quantifying Host-Pathogen Protein-Protein Interactions, Larah Gorayeb

Electronic Theses and Dissertations 2020 - Present

Host-pathogen protein-protein interactions are the key drivers of infectious diseases, where events such as pathogen adhesion and signaling are directly associated with disease severity. One example of this is Malaria, in which the Plasmodium falciparum infected erythrocytes adhere to endothelial receptors to avoid splenic clearance. This study investigated interactions between PfEMP1 CIDR1 field domains and host receptor CD36 using a multiplex platform to quantitatively determine binding affinities. Variants RP18 and RP27 exhibited strong affinity, suggesting a role in cytoadherence and disease severity. To evaluate broader applicability, the platform was expanded to the interaction between host protein SIVA1 and Helicobacter pylori …

Cerebellar Oligodendrocytic Α-Synuclein Pathology And Dentate Nucleus Neuronal Hypertrophy In Parkinson’S Disease, Diego Iacono, Hui Peng, John Paul Bouffard, Roger Kurlan

Department of Neurology Faculty Papers

Idiopathic Parkinson's disease (iPD) research has historically prioritized basal ganglia dysfunction and neuronal Lewy body pathology, often overlooking cerebellar and non-neuronal cells contributions. This study investigates cerebellar neuropathology in iPD, specifically focusing on neuronal and non-neuronal cells of the dentate nucleus (DN) and its adjacent white matter (DN-WM). We systematically assessed autopsy-confirmed iPD brains vs. age-matched controls using immunohistochemistry and stereology-based morphometry methods. The study evaluated α-synuclein pathology, other common age-related co-occurring pathologies (β-amyloid, Tau, neuroinflammation), myelin integrity (Luxol-Fast-Blue), and neuronal volumetric changes in the DN of the cerebellum. In iPD brains, we identified intracytoplasmic α-synuclein inclusions within oligodendrocytes across …

Late Presentation Of Shone’S Complex With Severe Left Ventricular Dysfunction, Refal Mahrouqi, Asayil Almarjan, Ahmed Sultan, Sheeren Khaled, Elnazeer O Ahmed

Journal of the Saudi Heart Association

Background:

Shone’s complex is a rare CHD, often including supravalvular mitral ring, parachute MV, subaortic stenosis, and coarctation of the aorta. Variants of this complex have been reported with considerable anatomical and clinical heterogeneity.

Case Presentation:

a 14-year-old girl with severe cachexia (BMI 12.37) and cardiac failure, referred for CHD evaluation. Echocardiography and CT revealed a bicuspid AV, severe valvular and subvalvular aortic stenosis, subaortic membrane, muscle ridge causing LVOT obstruction, dilated LV with EF 25–30%, and VSD.

Intervention:

MV replacement, Konno procedure with LVOT and annular enlargement, AV replacement, and TV repair. She had an uneventful ICU course

Perioperative Pressure Injury Prevention Education Program, Stephanie M. Reed

Walden Dissertations and Doctoral Studies

Pressure injuries (PIs) are localized injury to the skin and/or underlying tissue, usually over a bony prominence, resulting from sustained pressure including pressure associated from shear. Surgical patients are estimated to represent 42% of hospital acquired PIs. PIs result in poor patient outcomes, increase length of stay, add billions to heath care costs are no longer reimbursed by Centers for Medicare/Medicaid Services. Prevention of PI is different in the perioperative setting due to the complexities of surgery. This project focused on developing, delivering, and evaluating a robust education program for perioperative staff on PI prevention in the perioperative setting. The …

Contraception In The Ed: Understanding Education And Opportunities For Clinicians To Advise Patients, Hannah B. Lewis, Teagan R. Mccarthy, Dara Kass, Jennifer L. Kahoud

Department of Emergency Medicine Faculty Papers

Introduction: The United States faces a high rate of unwanted pregnancies. Despite this, many people continue to face barriers to accessing contraception. The emergency department (ED) can help bridge these gaps, but emergency clinicians must first feel comfortable offering contraceptive services. In this study, we sought to determine emergency clinician comfort in prescribing contraceptives and educating patients on their use. We also gauged clinician interest in receiving education specifically geared toward contraceptive care.

Methods: We conducted an online survey of ED residents, attendings, and advanced practice clinicians at Thomas Jefferson Univerity Hospital and affiliates in both the urban and suburban …

Staff Education To Improve Nursing Knowledge Of Catheter-Associated Urinary Tract Infection Prevention Practices, Maylin Fernandez

Walden Dissertations and Doctoral Studies

In this Doctor of Nursing Practice quality improvement project, I used a staff education intervention to address nursing knowledge gaps related to catheter-associated urinary tract infection (CAUTI) prevention in a large outpatient urology clinic in the southeastern United States. Registered nurses (N = 28) participated in a single, 45-minute, in-person education session comprising PowerPoint slides, facilitated discussion, and printed job aids based on national guidelines. I used a single-group pre-/posttest design to evaluate the effect of the intervention. The primary outcome was staff knowledge measured using a paper-based, 17-item knowledge test administered immediately before and after the session. The secondary …

Multi-Trait Polygenic Scores For Copd And Copd Exacerbations Implicate Druggable Proteins, Tinashe Chikowore, Yi Ding, Bogdan Pasaniuc, Diana Chang, Qingwen Chen, Jessica A Lasky-Su, Julian Hecker, Martin D Tobin, Jing Chen, Sean Kalra, Katherine A Pratte, Hae Kyung Im, Emily S Wan, Ani Manichaikul, Edwin K Silverman, Russell P Bowler, Leslie A Lange, Victor E Ortega, Michael H Cho, Matthew R Moll

Faculty, Staff and Student Publications

BACKGROUND

We constructed multi-trait polygenic risk scores (PRSs) predicting chronic obstructive pulmonary disease (COPD) and exacerbations, validated their performance in diverse cohorts, and identified PRS-related proteins for potential therapeutic targeting.

METHODS

PRSmix+, a multi-trait PRS framework, is used to train a composite PRS (PRSmulti) in COPDGene non-Hispanic White participants (n = 6,647). Associations of PRSmulti with COPD status (GOLD 2–4 vs. GOLD 0 or ICD) and exacerbation frequency were tested in COPDGene African American (n = 2,466), ECLIPSE (n = 1,858), Mass General Brigham Biobank (n = 15,152), and All of Us (n = 118,566). …

Diabetes Mellitus And Its Association With Tuberculosis Clinical Presentation And Treatment Outcomes: Results From A Prospective Cohort Study In Ghana, Monica Baaba Jones, Kwadwo Ansah Koram, Francis Anto, Michael Lauzardo, Blanca I. Restrepo, Margaret Lartey, Hafisatu Gbadamosi, Awewura Kwara

School of Medicine Publications

Background: Tuberculosis (TB)-diabetes is a growing public health threat in TB-endemic settings. We aimed to determine diabetes prevalence among TB patients in Greater Accra and its association with TB clinical presentation and treatment outcomes.

Methods: We enrolled 204 adults (≥20 years) with bacteriologically confirmed pulmonary TB across 14 health facilities. At treatment initiation, participants were screened for diabetes using self-report, fasting plasma glucose, and glycated hemoglobin, following standard diagnostic criteria. Baseline characteristics were recorded, and participants were followed to determine TB treatment outcomes. Associations between diabetes, baseline characteristics and treatment outcomes were assessed using bivariate and multivariate analysis in STATA. …

Correction: Exploiting Prmt5 As A Target For Combination Therapy In Mantle Cell Lymphoma Characterized By Frequent Atm And Tp53 Mutations, Yijing Li, Wei Wang, Lixin Rui, Michael Wang

Faculty, Staff and Student Publications

No abstract provided.

Examining Moderators In The Relationship Between Injury/Injury Anxiety And Eating Disturbances In College Women Athletes, Lydia M. Reichley

Undergraduate Theses

Introduction: Injury and injury-related anxiety are common in collegiate athletes and may contribute to maladaptive psychological and behavioral outcomes, including eating disturbances. This study examined the relationship between injury/injury anxiety and eating disturbances, and whether athletic identity, injury self-efficacy, and body shame moderated this relationship. Methods: A cross-sectional design was used with 57 female collegiate and club athletes from Bellarmine University (M age = 19.98 + 1.37). Participants completed an online survey including the Sport Injury Anxiety Scale (SIAS), Athletic Identity Measurement Scale (AIMS), Athletic Injury Self-Efficacy Questionnaire (AISEQ), Eating Attitudes Test (EAT-26), and the Objectified Body Consciousness Scale (OBC; …

Versatile Smad2 And Smad3 Epitope-Tagged Mouse Models For Genomic Profiling Of Tgfβ Signaling: Uncovering Gdf9-Smad2/3 Targets, Kaori Nozawa, Suni Tang, Masahito Ikawa, Diana Monsivais, Martin M Matzuk

Faculty, Staff and Students Publications

Transforming growth factor β (TGFβ) signaling pathways are integral for a plethora of biological processes. SMAD2 and SMAD3 are the principal transcriptional effectors of TGFβ superfamily ligands, yet quantitative, genome-wide mapping of their DNA-associated complexes under physiological contexts has remained limited due to the lack of specific, robust models. Here, we generated two versatile epitope-tagged mouse models in which endogenous SMAD2 and SMAD3 proteins are globally tagged with hemagglutinin (HA) and podoplanin (PA) sequences, respectively, enabling high-fidelity profiling of SMAD2 and SMAD3 binding across tissues. To demonstrate the broad application of our models, we exemplified the usage of our lines …

Correction: The Formation Of Tau Pore-Like Structures Is Prevalent And Cell Specific: Possible Implications For The Disease Phenotypes, Julia E Gerson, Marcos Guerrero-Munoz, Juan C Troncoso, George R Jackson, Rakez Kayed

Faculty, Staff and Students Publications

This corrects the article "The formation of tau pore-like structures is prevalent and cell specific: possible implications for the disease phenotypes" in volume 2, 56.

Multi-Organ Physiologic Deficits During Exercise Identify Clinical And Molecular Predisposition To Heart Failure With Preserved Ejection Fraction, Andrew Perry, Phillip Lin, Quanhu Sheng, Shilin Zhao, Kaushik Amancherla, Michael Y Mi, Takenori Ikoma, Laura P Cohen, Ilya Giverts, Joseph Campain, Joao A C Lima, Wendy S Post, Kent D Taylor, Robert Gerszten, Stephen S Rich, Russell Tracy, Peter Durda, Alexis C Wood, Rajeev Malhotra, Jerome I Rotter, Clary Clish, Matthew Nayor, Eric R Gamazon, Ravi V Shah, Gregory D Lewis

Faculty, Staff and Students Publications

Background: Exercise unmasks limitations in multi-organ system reserve capacity characteristic of heart failure with preserved ejection fraction (HFpEF). However, the metabolic and genetic underpinnings of exercise deficits, and their cumulative contribution to HFpEF severity and prognosis, remain incompletely understood.

Methods: We used invasive cardiopulmonary exercise testing (iCPET), metabolite profiling, and genomics to simultaneously characterize seven exercise physiologic deficits in HFpEF patients: reduced exercise stroke volume and heart rate, steep pulmonary capillary wedge pressure/cardiac output (PCWP/CO) slope, elevated pulmonary vascular resistance, pulmonary mechanical limitation to exercise, impaired peripheral oxygen extraction, and obesity-related exaggerated metabolic cost of initiating exercise. We first mapped …

Exploring Lived Experiences Faced By Latina Breast Cancer Survivors, Deborah Fortino

Doctoral Dissertations and Projects

The purpose of the hermeneutic phenomenological study was to explore and understand lived experiences of Latina breast cancer survivors through semi-structured interviews on the Zoom Video Conferencing platform. The theory that guided the study was the Health Belief Model (HBM), a health behavior framework that explored Latina breast cancer survivors' behaviors concerning health (Rosenstock et al., 1988). Furthermore, Fleming et al.’s (2003) five steps of gathering qualitative data and Ajjai and Higgs’s (2007) six stages of data analysis were utilized to acquire the information to explore the phenomenon of Latina breast cancer survivors’ lived experiences. The sample population included nine …

Oxygen Under Pressure: A Comparative Study Of Maximal Oxygen Uptake In Firefighters And Civilians, Jordan N. Hunt

Doctoral Dissertations and Projects

The purpose of this study aimed to investigate and compare V̇O2max levels between firefighters and age-matched individuals from the general population. This study used a quantitative, comparative, cross-sectional design to assess differences in directly measured V̇O2max with a breath-by-breath portable analyzer between firefighters and matched civilians, determine the percentage of firefighters meeting NFPA recommended fitness thresholds, and examine the accuracy of estimated V̇O2max values. A total sample size of 52 participants (26 per group) participated in this study. Firefighters exhibited significantly higher directly measured V̇O2max and V̇O2peak than age-, sex-, and BMI-matched individuals from the general population. Firefighters in this …

Reference Proteins To Improve Core 1 And Core 2 Alzheimer's Disease Csf And Plasma Biomarkers, Linda Karlsson, Nicolas R Barthélemy, Kanta Horie, Suzanne E Schindler, Brian A Gordon, Cyrus A Raji, Tammie L S Benzinger, John C Morris, Randall J Bateman, Et Al.

2020-Current year OA Pubs

Concentration-based fluid biomarkers represent an informative and cost-effective way to detect and monitor Alzheimer's disease (AD) pathology. However, non-AD-related interindividual variation in biofluids can also affect biomarker concentrations. Here, we investigated whether normalization of CSF and plasma biomarkers to reference proteins, such as amyloid-β40 (Aβ40) and non-phosphorylated mid-region tau (np-tau), improves their robustness and reliability of representing AD pathology load. Using the Swedish BioFINDER-2 cohort [n = 1702, 50.7% male, mean (standard deviation) age 68.4 (12.2) years], we compared the associations between tau/Aβ-PET load and fluid biomarkers alone versus biomarkers in a ratio with a reference protein (Aβ40 or np-tau) …

Emerging Paradigms In Connectome-Guided Neurosurgery For Central Nervous System Tumors: A Narrative Review Of Structural And Functional Connectomics, Tirath Patel, Hamza Yousuf Ibrahim, Muhammad Abbas, Muzna Amir Ali, Sana Sohrab, Kinza Nawaz, Syeda Ramish Zehra Kazmi, Bhumi Daishik Patel, Nikhilesh Anand

School of Medicine Publications

Connectomics is a comprehensive mapping of structural and functional brain networks. It has introduced a paradigm shift in neurosurgery by redefining brain tumors as network disorders rather than isolated lesions. Unlike traditional surgeries, connectome-guided neurosurgery conceptualizes brain tumors as network disorders and aims to preserve brain function in resection. The objective was to study the role of connectome-guided neurosurgery in the management of Central Nervous System tumors and the use of structural and functional connectomics in tumor resection while preserving neurological function. Articles have been identified by searches of PubMed, Scopus and Google scholar from January 2000 to May 2025, …

Navigating The Ethical Landscape Of Ai Created Responsibility Gaps In Healthcare, Kelsey Dwyer '26

Honor Scholar Theses

This work is a philosophical analysis of the ethical dilemma of AI-created responsibility gaps, or the idea that it is challenging to find someone to hold responsible for outcomes produced by an autonomous system. In particular, my focus is specifically on addressing responsibility gaps created by AI used in healthcare. This complex issue of responsibility gaps becomes more intense in the setting of critical areas of life like healthcare, where moral responsibility is a foundational component of upholding medical ethics. My paper will take a deep dive into exploring the intricacies of this complex problem by applying a pre-existing conceptual …

The Influence Of Lower-Body Explosive Power, Speed, And Eye-Foot Coordination On Long Jump Performance: A Path Analysis Study, Alwi Fahruzy Nasution, Imanuddin Siregar

Indonesian Journal of Research in Physical Education, Sport, and Health

Background: Long jump performance is influenced by various physical and coordinative components, particularly lower-body explosive power, running speed, and eye-foot coordination. However, limited studies have simultaneously examined the predictive relationships among these variables using a path analysis model among university students in physical education programs. Objective: This study aimed to analyze the direct and indirect predictive relationships among lower-body explosive power, speed, eye-foot coordination, and long jump performance. Methods: This study employed a quantitative, cross-sectional, correlational design with path analysis. The sample consisted of 30 students selected using a total sampling technique. Data were collected using standardized physical performance tests, …

Development And Validation Of A Basic Skill-Based Swimming Training Model For Beginner Athletes: An Addie Approach, Martinus Martinus, Hilmy Aliriad, Karmila Utari, I Bagus Endrawan, Muhamad Rohadi

Indonesian Journal of Research in Physical Education, Sport, and Health

Background: Mastery of basic swimming skills is foundational for the development of beginner athletes, yet structured, validated training models tailored to the Indonesian context remain scarce. Objective: This study aims to develop a basic skill-based swimming training model that is content-valid, practical, and effective in improving swimming technical ability in beginner athletes aged 8-12 years, through systematic, staged development procedures. Methods: The research used the Research and Development (R&D) ADDIE model approach with staged procedures: (1) drafting the initial model based on needs analysis, (2) expert validation by four active swimming coaching validators using the Content Validity Ratio (CVR) instrument …

La Dolce Vita Or The American Way: A Comparative Study Into The Italian And American Healthcare Systems Through An Analysis Of Total Knee Replacements, James (Jim) Mcmurray '26

Honor Scholar Theses

This thesis presents a comparative study of the Italian and the American healthcare systems, using Total Knee Replacements (TKRs) as a standardized metric to evaluate the health policy, financing, and patient outcomes. Despite the United States spending over $10,000 more per capita on healthcare than Italy, American life expectancy is 5 years shorter than Italian life expectancy. Through a mixed-methods analysis of data from the American Joint Replacement Registry (AJRR), the Programma Nazionale Esiti (PNE), the Registri Italiani di ArtoProtesi (RIAP), and the HCUPnet (AHRQ) database, this research identifies multiple disparities throughout the system. Key findings in this thesis include …

Developing Nursing Education On The Assessment Of Asthma Patients With Symptoms Of Shortness Of Breath In Urgent Care, Abigail Akorfa Adase

Walden Dissertations and Doctoral Studies

This quality improvement project aimed to enhance the assessment of dyspnea in patients presenting with shortness of breath, particularly those with asthma, through a staff education program. At the practice site, staff primarily relied on SpO₂ readings to evaluate dyspnea, which often led to misassessment and delays in care. The project addressed this gap by providing urgent care staff with training on comprehensive assessment techniques, including evaluation of respiratory rate, work of breathing, ability to speak, patient history, and use of validated tools such as Borg’s scale and peak flow meters. Twenty triage staff members participated, including licensed practical nurses, …

Body Composition Profiles And Physical Readiness Among Paragliding Trainees: A Cross-Sectional Study, Nanang Indardi, Anies Setiowati, Fajar Syamsudin, Didik Cahyono, Johnlenon Aliser, Sangheon Park

Indonesian Journal of Research in Physical Education, Sport, and Health

Background: Physical readiness is essential for performance and safety in paragliding. Body composition has been recognized as an important factor associated with physical performance; however, evidence regarding its collective influence on physical readiness among paragliding trainees remains limited. Objective: This study aimed to examine the role of body composition as an integrated correlate of physical readiness among paragliding trainees using a multiple regression analysis. Methods: A quantitative cross-sectional study was conducted involving 24 paragliding trainees selected through purposive sampling. Body composition variables, including body mass index (BMI), body fat percentage (PBF), skeletal muscle mass (SMM), and basal metabolic rate (BMR), …

Analysis Of Rule Violations Leading To Disqualification In Youth Swimming Competitions: Evidence From Indonesia, Ika Novitaria Marani, Ari Subarkah, Heni Widyaningsih, Ricky Susiono, Muhammad Syahrul Ramadhan

Indonesian Journal of Research in Physical Education, Sport, and Health

Background: The purpose of this study was to determine how disqualifications of competition rules in swimming competitions are committed. Rules must be obeyed when competing, and there are consequences for swimmers who violate them. Objective: To find out how the disqualification of the rules of the competition game in the swimming sport is carried out in the swimming competition. Methods: The research was conducted at the GBK Senayan Swimming Pool, and the study used a descriptive observational design. The population in this study consists of all beginner-level swimmers who take part in the 2025 DKI Jakarta swimming competition in Indonesia. …