Digital Commons Network^™

Advancing Hand Therapy Practice Through Specialized Clinical Reasoning And Patient Education, Candace Heinlein

Capstone Projects

This doctoral capstone experience (DCE) was completed at Corewell Health Grand Rapids Hospitals Hand Therapy Clinic and focused on two ACOTE concentration areas including advanced clinical practice skills and education. The experience combined hands-on clinical practice in a specialized outpatient hand therapy setting with the development of high-quality client education materials and home exercise programs (HEPs). Objectives were created to address identified needs through the creation of client education handouts, development of diagnosis-specific Medbridge HEP templates, and creation of training resources to improve therapist efficiency with Medbridge use. Outcomes of the project included improved access to evidence-based educational materials, reduced …

Dapk2 Regulates Pkm2 Phosphorylation At Threonine 45 To Facilitate Disturbed Flow-Induced Atherosclerosis, Yuan Zhao, Yuting Zhang, Runfa Yu, Kaixiang Cao, Litao Wang, Wenjia Ai, Jiang-Yun Luo, Lu Lu, Jun He, Yuan Zhou, Li Wang, Andrew H Baker, Yuqing Huo, Yiming Xu

Faculty, Staff and Students Publications

Background: Oscillatory shear stress (OSS), resulting from disturbed blood flow, is implicated in atherosclerotic plaque formation by incompletely understood mechanisms. This study aims to elucidate the involvement of death-associated protein kinase (DAPK) 2 in OSS-induced endothelial cell (EC) activation and atherosclerosis.

Methods: Publicly available resources, including genome-wide microarray, RNA sequencing, and single-cell RNA sequencing, were utilized to identify key OSS-sensitive regulatory factors. Techniques such as mass spectrometry, immunoprecipitation, proximity ligation assay, and RNA sequencing were employed to identify pyruvate kinase M2 (PKM2) as the binding protein of DAPK2 and determine the specific site of PKM2 phosphorylation by DAPK2. To assess …

From Beauty To Burden: Mapping The Health And Psychosocial Impacts Of Fragrances And Cosmetic Products Use In The Uae, Sharifa Alblooshi, Mariam Al Ali, Dana N. Abdelrahim, Suheir Awadalla

All Works

Background The dynamic beauty care sector in the Middle East is on an upward trend in the UAE; however, concerns persist about the side effects of this industry, attributed to chemical exposure, which is believed to contribute to skin problems and other health issues. In the UAE, there is a lack of data on consumer usage, awareness, and the health effects associated with it.Methods This study presents the results of an online survey administered to 461 female subjects in the United Arab Emirates as part of a cross-sectional study. The survey consisted of 55 questions on product use, knowledge, attitudes, …

What Patients Believe — And What They're Actually Doing, Michael Weitzner Dds

Virginia Dental Journal

No abstract provided.

Va Dent J April, May And June 2026

Virginia Dental Journal

This issue of the Virginia Dental Journal highlights the key forces shaping dentistry in 2026, including workforce shortages, legislative advocacy, and emerging technologies. It examines the impact of artificial intelligence on clinical care and regulation, alongside ongoing efforts to expand access to care and strengthen the dental workforce in Virginia. The issue also addresses changes in professional engagement, practice management trends, and the importance of organized dentistry in navigating policy and industry challenges. Overall, it underscores a profession adapting to rapid change while prioritizing patient care and collaboration.

Health Data And Policy Related To Methamphetamine-Use Suicide In Mississippi, Mary C. Drane

Honors Theses

The purpose of this research is to investigate how methamphetamine use in Mississippi, especially in its rural areas, intersects with public health, policy, and suicide outcomes in the state. Mississippi's methamphetamine crisis has evolved significantly, shifting from locally produced drugs to cartel-supplied crystal methamphetamine, while state and federal policies have struggled to keep pace with the scale and complexity of the problem. Using a convergent parallel mixed-methods design, this research analyzed CDC Wonder multiple causes of death data and SAMHSA Treatment Episode Data Set Admissions (TEDS-A) data from 2018 to 2024 alongside four qualitative key informant interviews with stakeholders across …

Acute Traumatic Aortic Injury: What The Radiologist Needs To Know, Jason Au, Erika Odisio, Gustavo S Oderich, Daniel Ocazionez, Cihan Duran, Thanila Macedo

Faculty, Staff and Students Publications

Acute traumatic aortic injury (ATAI) is a rare but life-threatening consequence of blunt trauma that requires prompt diagnosis and accurate imaging assessment. This review presents an imaging-based approach to ATAI, with emphasis on computed tomography angiography (CTA) as the first-line modality for diagnosis, grading, treatment planning, and follow-up. CTA enables the detection of both direct and indirect signs while also allowing for the assessment of lesion severity, extent, and associated findings that may influence management. Familiarity with common mimics and anatomic variants improves diagnostic confidence and helps avoid false positive interpretations. Careful protocol optimization, including multiphasic acquisition, bolus timing, and …

Three-Dimensional Imaging Of Neuronal Activation Patterns In Chronic Neuropathic Pain And Opioid Pharmacology, Madeline Martinez

Electronic Theses and Dissertations 2020 - Present

Chronic neuropathic pain severely diminishes quality of life, yet the supraspinal neural circuits that sustain pain perception and mediate analgesic relief remain incompletely characterized. While peripheral and spinal pain pathways are well established, relatively few studies have mapped pain- or opioid-related neuronal activation across the entire brain. This dissertation employed activity-dependent genetic labeling (TRAP2/Ai9), whole-brain tissue clearing, light sheet microscopy, and graph-theoretic network analysis to characterize brain-wide activation patterns across chronic pain and analgesic conditions in mice.

In Chapter 1, we mapped supraspinal neuronal activation in a bilateral spared nerve injury model of chronic neuropathic pain. Although no individual region …

Exploring Perspectives Of Autistic Individuals And Caregivers On Autism Inclusive Services In Public Libraries, Ayva J. Rose

LSU Master's Theses

Public libraries are increasingly recognized as important community hubs designed to promote literacy, learning, language, family engagement, and inclusivity. Despite this, autistic individuals may experience language, literacy, sensory, and social differences that could impact their ability to participate in literacy-based programming in libraries. Librarians currently report a desire to provide services that not only include but meaningfully support autistic children in their families; however, little research has examined how key stakeholders within the autism community perceive autism-inclusive programming within libraries. This research seeks to explore these perspectives and identify (1) perceived barriers to attending children’s library programs, (2) accommodations and …

Can Music-Based Interventions Improve The Prelinguistic Skills Of Young Children On The Autism Spectrum? A Systematic Review, Blythe Serrano

SACAD: Scholarly Activities

Many children on the autism spectrum have difficulty developing prelinguistic skills

such as joint attention, purposeful vocalization, and gesture, which are strongly

related to later expressive and receptive language development. This systematic

review aimed to evaluate the effectiveness of music-based interventions in

supporting the development of these foundational prelinguistic skills in young

children on the autism spectrum. Five databases were searched, yielding a total of

332 results. Five articles ultimately met criteria for inclusion. Results of these studies

were mixed, with studies in which the intervention was delivered by a professional

rather than a caregiver yielding more positive results. Additional …

Digital Touchpoints: Investigating Contact Page Accessibility And Visual Authenticity Within Medical Tourism Health Websites, Alicia Mason, Elizabeth Spencer, Kristen Livingston, Treyton Meyers, Sakshi Bhati, Himika Akram

Faculty Submissions

This study examines two critical digital touchpoints on medical tourism provider (MTP) websites: (1) the accessibility of contact pages which often function as entry points for inquiries, scheduling, and pre-travel coordination, and (2) the authenticity of visual imagery used to shape expectations about care environments, personnel, and technological capacity. A sample of 105 MTPs across all six World Health Organization regions were analyzed using quantitative web accessibility testing and qualitative visual analysis. Results indicate pervasive accessibility errors on contact-page touchpoints and extensive reliance on inauthentic imagery to depict patients, providers, and medical technologies. Together, these practices may distort user expectations …

Life Skills For Individuals In A Juvenile Detention Center, Carrington Brown

Student Capstone Papers

This capstone project involved the development, implementation, and evaluation of a life skills program for justice-involved youth in a juvenile detention setting. Guided by a needs assessment, the program targeted financial literacy, job readiness, professionalism, and soft skills through structured sessions incorporating education, interactive activities, and group discussion. Findings from pre- and post-surveys and qualitative feedback indicated improved knowledge, confidence, and readiness for community reintegration, supporting the value of rehabilitative, occupation-based programming.

"I Wasn't Broken": Addressing Stigma Associated With Dementia While Walking The Talk For Dementia, Kate Irving, Fernando Aguzzoli Peres, Walter D. Dawson, Jonathan Adrián Zegarra-Valdivia, Lingani Mbakile-Mahlanza, Sherril B. Gelmon

Institute on Aging Publications

INTRODUCTION:Walking the Talk for Dementia (WTD) convenes people from every continent and multiple perspectives, including people with lived experience, in a 40- km walk followed by a 2-day symposium. The aim is collective reflective dialogue about dementia stigma without the burden of professional hierarchies.

METHODS: Qualitative reflections during and immediately following the walk were analyzed using content analysis to identify common themes.

RESULTS: Three themes demonstrate an evolution of perspectives about dementia and stigma: “meeting the person not the label”, “a community in solidarity”, and “I wasn’t treated like I was broken, and I wasn’t broken.”

DISCUSSION: WTD created an …

Health Insurance Literacy Among College Students At The University Of South Carolina, Emma J. Smith, Lorie Donelle Phd, Rn, Fcan, Robin Dawson

Caroliniana Undergraduate Research Journal

Purpose: This study aims to investigate the health insurance literacy skills of graduate college students and undergraduate college students.

Methods: A cross-sectional research design incorporated a 20-item questionnaire to examine college students’ knowledge of common health insurance terms and definitions, as well as their perceived understanding of health insurance. Descriptive analyses were conducted of participant demographics, health insurance literacy scores were summarized, and common health insurance policies were tested through a readability checker.

Results: The majority of students were between the ages of 18-25 and undergraduate students. More than half of the participants were female, and more …

The Role Of The "Indulgent Mindset" As A Modulator For Neuropsychiatric Biomarkers And Self-Reported Mental Wellbeing, Riva Ranier, Anika Anika, Sarah Simon, Ethan Chau, Emma Monte, Madison Retzloff, Johann Luna, Susan Helm

Seaver College Research And Scholarly Achievement Symposium

The Role of the "Indulgent Mindset" as a Modulator for Neuropsychiatric Biomarkers and Self-Reported Mental Wellbeing

Objective: Limited understanding persists regarding how an "indulgent mindset" about food shapes neuropsychiatric outcomes. Building on the "milkshake study" demonstrating that mindset modulates ghrelin response independent of nutritional content, this pilot study examines whether an indulgent mindset intervention affects neuropsychiatric biomarkers and mental wellbeing.

Methods: Women ages 19-65 (n=35; intervention n=17, control n=18) completed a 6-month randomized trial with baseline and post-intervention assessments including 3-day food diaries, mental wellbeing questionnaires, and comprehensive metabolomics (Iollo panel across mental health, metabolic health, gut microbiome, brain health, …

Statistical Inference Is Not Moral Reasoning: The Case Against Ai On Hospital Ethics Boards, Elan J. Haronian

Seaver College Research And Scholarly Achievement Symposium

As generative AI becomes more integrated in healthcare, it seems inevitable that AI will eventually be used on hospital ethics committees. However, before implementation, their roles need careful consideration. Although AI promises to reduce costs, increase efficiency, and reduce human workloads, there are important ways in which it is limited, especially when human emotion and connection are crucial, as in clinical ethics boards.

In this paper, I highlight several problems preventing AI from being useful on hospital ethics boards. These include issues of opaque reasoning (the “black box” problem), liability, transparency, privacy, and consent. While there are proposed frameworks for …

Living With Pets: The Science Behind Immune Development, Mitchell Wood

Osmosis Magazine

No abstract provided.

Seeing The Future: How Chemically Modified Vitamin A Slows Blindness, Marty Snyder

Osmosis Magazine

No abstract provided.

Milk-Fed Astronauts In A Microbial Galaxy, Charlie Lanning

Osmosis Magazine

No abstract provided.

Designing Eco-Islamic Memory Palace Media To Reduce Math Anxiety And Enhance Academic Resilience, Annas Solihin, Neni Mariana, Budi Purwoko

Jurnal Kajian Bimbingan dan Konseling

Math anxiety continues to hinder students' performance and emotional well-being in elementary mathematics education. This study aimed to develop and test the effectiveness of Eco-Islamic Memory Palace Media in reducing math anxiety and strengthening academic resilience. Employing the Plomp development model, the study involved three phases: preliminary research to identify psychological needs, prototyping of the media design, and a formative evaluation with expert validation and empirical testing on students (N = 24). The media integrated environmental imagery and Islamic values into visual-spatial mnemonic structures to create meaningful, calm, and emotionally safe learning experiences. Quantitative data analysis showed a significant decrease …

Bridging Movement Science And Clinical Care: Advancing Evidence-Based Scoliosis Care Through Professional Education And Outreach Initiatives, Megan B. Tenery

OTD Capstone Projects

This doctoral capstone project was completed in collaboration with Spiral Spine Pilates (SSP), a Pilates studio specializing in scoliosis that serves clients from adolescents to older adults. SSP offers virtual and in-person private lessons, group classes, teacher training, and a scoliosis-focused retreat. These services are designed to educate individuals with scoliosis and movement practitioners on evidence-based, functional correction movements that support daily living. The primary objectives of this project were to expand SSP’s educational and community reach through the development of a new Pilates certification, an educational email series, a health and wellness podcast, and other outreach efforts. The primary …

A Rare Case Of Cutaneous Extramedullary Hematopoiesis In Chronic Myeloid Leukemia, Bennett Christie-Nguyen, Hanadi El Achi, Levani Iashvili, Amer Wahed, Brenda Mai, Jacob Armstrong

Faculty, Staff and Student Publications

Cutaneous extramedullary hematopoiesis (CEH) is a rare manifestation of extramedullary hematopoiesis (EMH), a process typically associated with fetal development or myeloproliferative neoplasms. EMH most commonly involves the spleen, liver, and lymph nodes, with CEH being exceedingly rare in chronic myeloid leukemia (CML). Here, we present a 34-year-old Hispanic male with multiple bilateral lower extremity lesions, right buttock and leg pain, fatigue, and splenomegaly, who was found to have chronic-phase CML. Punch biopsy of one of the skin lesions demonstrated dermal infiltration by maturing hematopoietic elements, including granulocytes, megakaryocytes, and erythroid precursors, with fluorescence in situ hybridization (FISH) testing confirming a …

A Tv-Bm3d Iterative Algorithm For Vmat-Ct Reconstruction

Faculty, Staff and Students Publications

Volumetric modulated arc therapy-computed tomography (VMAT-CT), which is the CT reconstructed using the portal images collected during VMAT, can potentially be an effective onsite imaging tool. The goal of this study was to propose an iterative reconstruction algorithm that can further improve the image quality of VMAT-CT and reduce the number of failed reconstructions. An iterative algorithm combining total variation (TV) with block-matching and 3D filtering (BM3D) was proposed, addressing the L1-L2 regularization problem using the split Bregman method. We collected portal images from 67 VMAT cases including 50 phantom and 17 real-patient cases. Both Feldkamp-Davis-Kress (FDK) and TV-BM3D iterative …

Constitutive Ampk Activation Prevents Hepatocellular Carcinoma Development Through Inhibition Of Hnf4Α Activity, Fiyad Alsarmi, Boyuan Sang, Nagireddy Putluri, Jeanine L Van Nostrand

Faculty, Staff and Students Publications

Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality and is largely driven by metabolic disorders such as obesity and type 2 diabetes. The AMP-activated protein kinase (AMPK) is a master regulator of metabolism, and its activation has been proposed as a therapeutic strategy for treating metabolic disorders. However, although AMPK activity is down-regulated in HCC, the precise role of AMPK in HCC development has not been clearly delineated. Here, we investigated the ability of constitutive AMPK activation to prevent HCC development using a constitutively active AMPK transgenic mouse model and a pharmacological AMPK activator. We observed that AMPK …

H3 Dopaminylation And Camkii Modulate Diffuse Midline Glioma Response To Cdk9 Inhibition, Ena I Campos-Hensley, Adanze N Nnyagu, W Austin Elam, Ai-Ni Tsao, Jack R Tremblay, Ruiying Ma, Alfred K Dei-Ampeh, Kieu Pham, Daniel C Kraushaar, Kwanha Yu, Calla M Olson, Akdes Serin-Harmanci, Benjamin Deneen, Jamie N Anastas

Faculty, Staff and Students Publications

Aberrant neurotransmitter signaling and transcriptional dysregulation are hallmarks of gliomagenesis and represent potential therapeutic targets. Monoamine neurotransmitters such as dopamine and serotonin primarily activate GPCRs but can also function epigenetically as histone H3 modifications. Here, we uncover mechanisms of crosstalk between monoamine neurotransmitter signaling, H3 dopaminylation, and RNA polymerase II (Pol2) transcription in diffuse midline glioma (DMG). We find that co-treatment with Pol2-targeting CDK9 inhibitors (CDK9i) and FDA-approved neuropsychiatric drugs, including selective serotonin reuptake inhibitors (SSRIs), synergistically reduces DMG growth. Mechanistically, CDK9i+SSRI treatment alters H3 dopaminylation patterns and represses synaptic and neurodevelopmental gene transcription associated with CDK9i resistance. Further phospho-proteomic …

Parental Awareness And Response To Cyberbullying: A Qualitative Study Of Nigerian Parents, Adaobi Jennifer Iloakasia, Nneka Anthonia Obumse

Jurnal Kajian Bimbingan dan Konseling

The problem of cyberbullying has been gaining momentum in modern society because of the dynamic development of digital technologies and the extensive use of social media by adolescents. This paper thus examined the parental cognition and reaction to cyberbullying of Nigerian parents with a particular emphasis on Anambra State. The research design in the study was a qualitative one, based on a phenomenological approach to reflect the experiences of parents. Purposive selection of parents with children in secondary schools was done (30 parents). The collection of data was done via semi-structured interviews, and thematic analysis was used to analyze the …

Navigating A Delicate Balance: Antibiotic Allergy In The Setting Of Renal Infection And Diabetic Ketoacidosis, Aun Bangash, Muhammad Bangash, Ruben M. Martinez Meza

School of Medicine Publications

Acute pyelonephritis is a bacterial infection of the renal parenchyma that requires prompt recognition and antibiotic therapy to prevent complications such as sepsis and chronic renal inflammation. We present a case of a 26-year-old woman with poorly controlled type 1 diabetes mellitus and a documented beta-lactam allergy who presented with atypical symptoms, including flank pain without urinary complaints. Laboratory evaluation demonstrated leukocytosis with a negative urinalysis. CT of the abdomen revealed left lobar nephronia with early contralateral involvement of the right kidney. Given her allergy history, she was treated with levofloxacin. During her hospital stay, she developed nausea, vomiting, and …

Structural Transformation Of A Hydrogel-Forming Cell Division Protein Zapb Of Multidrug Resistant Klebsiella Pneumoniae With Small Molecules, Ayesha Khan, M. Iqbal Choudhary, Sumaira Javaid, Humaira Zafar, Innokentiy Maslennikov, Atia-Tul Wahab

Pharmacy Faculty Articles and Research

Septal ring assembly protein ZapB (EMR18431.1) is involved in Z-ring formation, and nucleoid segregation during the bacterial cell division . It promotes cell division in the initial stages of the cell cycle through direct interaction with FtsZ, thus stimulating Z-ring assembly. The ZapB inhibition can make bacterial cell susceptible to primary antibiotics, and therefore considered as an important approach for adjuvent therapy against MDR bacterial infections. Hence in the current study, ZapB protein of multidrug resistant Klebsiella pneumoniae was cloned, and expressed in E. coli system. To understand its role, and to assess the mechanism of ZapB activation, the characteristic …

Abstract Book (Pdf), Department Of Psychiatry

Dept. of Psychiatry Research Symposium

Abstract book for the 4th Annual Department of Psychiatry Research Symposium held April 9, 2026.

Reirradiation Treatment Effects In The Clinic (Retec) Proposal - Proof Of Concept Based On Spinal Cord Dose Tolerance For Reirradiation With Stereotactic Body Radiotherapy, Jimm Grimm, Anand Mahadevan, Olusola Obayomi-Davies, Scott G. Soltys, Arjun Sahgal, Kristin J. Redmond, Michael T. Milano, Wolfgang A. Tomé, Kenneth Brooks, Scott Dodd, John Austin Vargo, Gopal Subedi, Jinyu Xue, Bisher Ebid, Felix Ehret, Byung-Han Andrew Rhieu, Christoph Fürweger, Rachel Grimm, Alexander Muacevic, Vitali Moiseenko, Shalom Kalnicki, Mark Mclaughlin, Lawrence R. Kleinberg, John R. Adler, Iris C. Gibbs

College of Health Professions Faculty Papers

BACKGROUND: Since the inception of spinal radiosurgery decades ago, the factors influencing spinal cord recovery have remained unclear. Elucidating these factors would aid in reirradiation planning and delivery. We describe modeling reirradiation normal tissue complication probabilities (NTCP) from compiled published data, akin to the collaborative Quantitative Analysis of Normal Tissue Effects in the Clinic (QUANTEC) and High Dose per Fraction, Hypofractionated Treatment Effects in the Clinic (HyTEC) projects.

PURPOSE: Simple dose-time recovery factors for the spinal cord serve as a basis to propose the Reirradiation Treatment Effects in the Clinic (ReTEC) project. ReTEC aims to define human organ recovery factors …