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Retrocyclin Rc-101 Overcomes Cationic Mutations On The Heptad Repeat 2 Of Hiv-1 Gp41, Christopher Fuhrman

Electronic Theses and Dissertations

Retrocyclin RC-101, a θ-defensin with lectin-like properties, potently inhibits infection by many HIV-1 subtypes by binding to the heptad repeat (HR)-2 region of gp41 and preventing six-helix bundle formation. In the present study, we used in silico computational exploration to identify residues of HR2 that interacted with RC-101 and then analyzed the HIV-1 Sequence Database at LANL for residue variations in the HR1 and HR2 segments that could plausibly impart in vivo resistance. Docking RC-101 to gp41 peptides in silico confirmed its strong preference for HR2 over HR1, and implicated residues crucial for its ability to bind HR2. We mutagenized …

Apoer2 Expression Increases Aβ Production While Decreasing Amyloid Precursor Protein (App) Endocytosis: Possible Role In The Partitioning Of App Into Lipid Rafts And In The Regulation Of Γ-Secretase Activity, Rodrigo A. Fuentealba, Maria Ines Barría, Jiyeon Lee, Judy Cam, Claudia Araya, Claudia A. Escudero, Nibaldo C. Inestrosa, Francisca C. Bronfman, Guojun Bu, Maria-Paz Marzolo

Open Access Publications

No abstract provided.

Molecular Classification And Prediction Of Metastatic Potential In Early Malignant Melanoma: Improvement Of Prognostic Accuracy By Quantitative In Situ Proteomic Analysis, Aaron J. Berger

Yale Medicine Thesis Digital Library

The incidence of cutaneous malignant melanoma continues to increase every year, and remains the leading cause of skin cancer death in industrialized countries. In spite of the aggressive nature of advanced melanoma, there are no standard biological assays in clinical usage that can predict metastasis. This may be due, in part, to the inadequacy of reproducible assessment of protein expression using traditional immunohistochemistry. This dissertation will discuss the use of tissue microarrays combined with quantitative in situ molecular analysis of protein expression to allow prediction of melanoma metastasis. Through the identification and validation of novel prognostic biomarkers, we seek to …

The Creativity And Aging Study: The Impact Of Professionally Conducted Cultural Programs On Older Adults, Gene D. Cohen, The Center On Aging, Health & Humanities, The George Washington University (Gw)

National Collaborative on Aging Faculty Publications

Executive Summary

In 2001, the National Endowment for the Arts developed a cooperative agreement with The George Washington University to conduct a multisite national study with the aim of measuring the impact of professionally conducted community based cultural programs on the general health, mental health, and social activities of older persons, age 65 and older. Referred to as the Creativity and Aging Study, the project’s formal title is “The Impact of Professionally Conducted Cultural Programs on Older Adults”. No previous study of this nature using an experimental design and a control group had been carried out. The study takes place …

Spontaneous Intracranial Arterial Dissection In The Young: Diagnosis By Ct Angiography, William C. Robertson, Curtis A. Given

Neurology Faculty Publications

BACKGROUND: Spontaneous carotid artery dissections have been rarely reported in children. Diagnosis has traditionally been confirmed by catheter arteriography. More recently diagnosis has been made by magnetic resonance imaging and magnetic resonance angiography; however the sensitivity of these techniques has yet to be determined. The authors are unaware of reports of carotid dissection confirmed by dynamic computed tomography (computerized tomographic arteriography) in the young.

CASE PRESENTATION: We recently evaluated a fourteen year-old male following the development of transient neurologic symptoms. There was no antecedent illness or trauma. Dynamic computed tomography revealed an intracranial dissection involving the supraclinoid segment of the …

Small B Cell Non-Hodgkins Lymphoma In Pakistan, Kanwal Aftab, Yasmin Bhurgri, Shahid Pervez

Department of Pathology and Laboratory Medicine

Objective: To study the pattern of small B cell lymphomas in Pakistan.

Methods: This descriptive study was carried out at the Aga Khan University Hospital pathology department including 1721 cases of Non-Hodgkins Lymphoma (NHL) diagnosed during a period of five years (1998-2002) and classified according to REAL/WHO classification. The antibodies used included Leukocyte Common Antigen (LCA), Pan B (CD20, CD79a), Pan T (UCHL-1), Bcl 2, Mib 1(Ki 67) and Cyclin D1 (Dako, Denmark).

Results: Out of the 1721 NHL cases, only 140 (8.1%) could be categorized as small B-cell NHL. The study group comprised small lymphocytic lymphoma/chronic lymphocytic leukemia (58 …

Embryonic Stem Cell-Derived Hematopoietic Stem Cells, Yuan Wang, Frank Yates, Olaia Naveiras, Patricia Ernst, George Q. Daley

Dartmouth Scholarship

Despite two decades of studies documenting the in vitro blood-forming potential of murine embryonic stem cells (ESCs), achieving stable long-term blood engraftment of ESC-derived hematopoietic stem cells in irradiated mice has proven difficult. We have exploited the Cdx-Hox pathway, a genetic program important for blood development, to enhance the differentiation of ESCs along the hematopoietic lineage. Using an embryonic stem cell line engineered with tetracycline-inducible Cdx4 , we demonstrate that ectopic Cdx4 expression promotes hematopoietic mesoderm specification, increases hematopoietic progenitor formation, and, together with HoxB4, enhances multilineage hematopoietic engraftment of lethally irradiated adult mice. Clonal analysis of retroviral integration sites …

Research News: 2005, No. 3, University Of Mississippi. School Of Pharmacy

Research News: Grants and Publications (2000-2014)

Grants, publications, technology transfer, special announcements

Information Interface - Volume 33, Issue 3 - August/September 2005, George Washington University, Himmelfarb Health Sciences Library

Information Interface (1976 - 2009)

News and information about Himmelfarb Health Sciences Library of interest to users. Includes articles on the library renovation, new faculty publications, and database search tips.

Research News: 2005, No. 2, University Of Mississippi. School Of Pharmacy

Research News: Grants and Publications (2000-2014)

Grants, publications, technology transfer, special announcements

Synthases, Joseph Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks

Pharmaceutical Sciences Faculty Patents

Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase. with or without a substrate bound in the active site.

Maternal Oral Health And Preterm Low Birth Weight In Pakistan., Amyn Lakhani

All ETDs from UAB

No abstract provided.

Cooperative Brains: Psychological Constraints On The Evolution Of Altruism, Jeffrey R. Stevens, Marc D. Hauser

Department of Psychology: Faculty Publications

Imagine an individual called "hunter" that expends a good deal of energy to capture a gazelle. As the hunter is consuming his small prey, a second individual called "recipient" approaches and begins feeding peacefully alongside the hunter. A few weeks later the roles reverse, such that the previous recipient has now captured a gazelle, and the previous hunter is taking advantage of the recipient's hard work. Could the hunter and recipient be Maasai warriors? Is it equally likely that they are common chimpanzees, African lions, or Nile crocodiles? All of these species hunt gazelle and live in groups, so why …

Differences In Peripheral Noradrenergic Function Among Actively Drinking And Abstinent Alcohol-Dependent Individuals., Ashwin A. Patkar, Charles A. Marsden, Prakash C. Naik, David A. Kendall, Raman Gopalakrishnan, Michael J. Vergare, Stephen P. Weinstein

Department of Psychiatry and Human Behavior Faculty Papers

We examined whether excessive alcohol consumption was related to changes in plasma levels of noradrenaline (NA) and whether these changes recover following abstinence. We also explored whether there were differences in NA levels between Type I and Type II alcoholics and controls during active drinking and abstinence. Plasma concentrations of NA were determined in (1) 27 Caucasian men with alcohol dependence who were regularly drinking (active drinkers) within 24 hours of hospitalization, (2) 29 Caucasian alcohol-dependent men who were in remission (abstinent for a minimum of three months), and (3) 28 race- and gender-matched healthy controls. NA concentrations were significantly …

Contributing Factors To Student Success In Anatomy & Physiology: Lower Outside Workload & Better Preparation., David E. Harris, Lynn Hannum, Sat Gupta

School of Nursing

Presents a study that examined the factors associated with the success in undergraduate Anatomy & Physiology coursework at Lewiston-Auburn College, University of Southern Maine in Lewiston. Details of the grading system used for the period of the study; Analysis of the independent variables that correlated significantly with the final course grades of the students; Relation between the amount of previous study of mathematics and science in both high school and college and the final course grades of the students.

Amyloid-Beta Peptide Induces Oligodendrocyte Death By Activating The Neutral Sphingomyelinase-Ceramide Pathway, Jiunn-Tay Lee, Jan Xu, Jin-Moo Lee, Grace Ku, Xianlin Han, Ding-I Yang, Shawei Chen, Chung Y. Hsu

Open Access Publications

No abstract provided.

Ionizing Radiation Induces A Stress Response In Primary Cultures Of Rainbow Trout Skin, Fiona Lyng, M. Lyons-Alcantara, P. Owell, Sharon Ni Shuilleabhain, Colin Seymour, D. Cottell, Carmel Mothersill

Articles

Fish skin is very vulnerable to damage from physical and chemical pollutants because it is in direct contact with the aquatic environment. In this study, the effect of g radiation on primary cultures of rainbow trout skin was investigated. Primary cultures containing two cell types, epidermal cells and goblet mucous cells, were exposed to doses ranging from 0.5–15 Gy 60Co g radiation. Expression of PCNA, c-myc and BCL2 was investigated as well as growth and levels of apoptosis and necrosis. Morphological and functional changes were also studied. The irradiated cultures showed evidence of a dose-dependent increase in necrosis and enhanced …

Synthases, Joseph Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks

Pharmaceutical Sciences Faculty Patents

Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase, with or without a substrate bound in the active site.

Commencement Program 2003, Loma Linda University

Commencement Programs

CONTENTS

2 | 2003 Events of Commencement

3 | The Academic Procession

4 | Significance of Academic Regalia

5 | The Speakers

12 | The University Honorees

21 | The School Honorees

29 | The Programs

• School of Medicine, 30
• School of Dentistry, 37
• Graduate School, 45
• School of Nursing, 55
• School of Allied Health Professions - Physical Therapy, 60
• School of Allied Health Professions, 68
• School of Public Health, 77

Synthases, Joe Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks

Pharmaceutical Sciences Faculty Patents

Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase, with or without a substrate bound in the active site.

Synthases, Joe Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks

Pharmaceutical Sciences Faculty Patents

Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase, with or without a substrate bound in the active site.

Dentalgram - Vol. 17, No. 05, Loma Linda University School Of Dentistry

Dentalgram

In this issue:

• Baccalaureate service planned for May 24; commencement to take place May 25
• School staff recognized during Administrative Professionals Days
• 13th annual Clinic With a Heart held April 13
• Students present table clinics at ADA and ADHA meetings
• Doctor's from Bangladesh and Nairobi study in the School of Dentistry

Androgen-Induced Recruitment Of Rna Polymerase Ii To A Nuclear Receptor–P160 Coactivator Complex, Maggie C. Louie, Hong Qiong Yang, Ai-Hong Ma, Wei Xu, June X. Zou, Hsing-Jien Kung, Hong-Wu Chen

Collected Faculty Scholarship

The androgen receptor, like other nuclear receptors, activates target genes by binding to hormone-responsive enhancers. Here we demonstrate that androgen induces robust recruitment of androgen receptor, members of the p160 coactivator family, and CREB-binding protein/p300 specifically at the distant enhancer of prostate-specific antigen (PSA) gene. Unexpectedly, we found that RNA polymerase II (Pol II) is directly recruited to the enhancer in a hormone-dependent manner, independent of the proximal promoter, and that the isolated PSA enhancer can mediate efficient androgen induction of transcription. Inhibition of the Pol II carboxyl-terminal domain kinase activity with low concentrations of flavopiridol blocks Pol II transfer …

Shiga Toxin–Producing Escherichia Coli In Montana: Bacterial Genotypes And Clinical Profiles, Jill K. Jelacic, Todd Damrow, Gilbert S. Chen, Srdjan Jelacic, Martina Bielaszewska, Marcia Ciol, Humberto M. Carvalho, Angela R. Melton-Celsa, Alison D. O'Brien, Phillip I. Tarr

Uniformed Services University of the Health Sciences

The diseases and virulence genes associated with Shiga toxin–producing Escherichia coli (STEC) are characterized incompletely. We analyzed, by polymerase chain reaction, 82 STEC isolates collected prospectively in Montana and profiled associated illnesses by patient chart review. All E. coli O157:H7 contained stx₂-group genes, as well as eae, iha, espA, and ehxA; 84% contained stx₁. Non-O157:H7 STEC less frequently contained stx₁( P = .046 ), stx₂ (P < .001), iha (P < .001), eae, and espA (P = .039 for both), were isolated less often from patients treated in emergency departments (P = .022), and …

Involvement Of Fatty Acid Pathways And Cortical Interaction Of The Pronuclear Complex In Caenorhabditis Elegans Embryonic Polarity, Chad A. Rappleye, Akiko Tagawa, Nathalie Le Bot, Julie Ahringer, Raffi V. Aroian

Open Access Publications

No abstract provided.

Synthases, Joseph Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks

Pharmaceutical Sciences Faculty Patents

Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase with or without a substrate bound in the active site.

Methods Of Making Modified Polypeptides, Joseph Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks

Pharmaceutical Sciences Faculty Patents

Novel polypeptides and the corresponding nucleic acids encoding such polypeptides are disclosed herein. The invention provides methods of making modified polypeptides by altering one or more amino acid residues involved in the active site of a preselected polypeptide.

How Should Governments Address High Levels Of Natural Radiation And Radon--Lessons From The Chernobyl Nuclear Accident And Ramsar, Iran, S. M. Javad Mortazavi, M. Ghiassi-Nejad, Azam Niroomand-Rad, P. Andrew Karam, John R. Cameron

RISK: Health, Safety & Environment (1990-2002)

The authors discuss the high levels of natural background radiation in Ramsar, Iran, and offer data indicating that this has had little effect on the health of Ramsar's inhabitants. The authors then examine the implications their research could have for public health policy.

Cancer Dose-Response Modeling Of Low Dose Radiation Exposure, Gizelle Susette Baker

MUSC Theses and Dissertations

Many late effects from exposure to ionizing radiation, including cancers, have been described in the literature. The identification and quantification of radiation-induced health effects is an important and complex issue. Recommendations for radiation safety and protection from the International Commission on Radiological Protection are made using a linear no threshold risk model on epidemiological data. A major obstacle in this process is the limited availability of data to directly measure the health effects of radiation on human populations. One way to circumvent this problem IS to use experimental data from laboratory animals and extrapolate across species to man. The cancer …

Outlook Magazine, Summer 2002

Outlook Magazine

No abstract provided.