Digital Commons Network^™

Guided Tissue Regeneration Of Localized Deep Combined 2-To-3- Wall Angular Defects: A Clinical Case Report With 15-Month Follow-Up

Journal IDA

Periodontitis is a chronic inflammatory disease affecting nearly 50 percent of U.S. adults. It is characterized by the irreversible destruction of the alveolar bone, periodontal ligament, and gingival tissues supporting the teeth. Periodontal breakdown results from a dysbiotic relationship between the plaque bacteria and host-immune response. Initiated by the bacterial plaque biofilm, the once normal and homeostatic host defenses intended to contain the subgingival inflammation become dysregulated and hyperactive. A diagnosis of an infrabony defect, also known as intrabony, vertical, or angular defects, is made when the base of the pocket is apical to the alveolar crest. It has been …

Role Of Microsurgery In The Evolution Of Periodontal Surgery

Journal IDA

Microscopes and microsurgery techniques have revolutionized the field of periodontology, offering enhanced visualization, precision, and improved clinical outcomes. This review explores the role of magnification in periodontal treatments, the benefits of microsurgical techniques, and their impact on patient recovery and procedural success. It examines how these advancements align with evolving surgical principles and addresses their implications for clinical practice and patient outcomes. By integrating microsurgery into periodontics, clinicians can achieve minimally invasive procedures with superior aesthetic and functional results. This paper also discusses the challenges and future directions of microsurgical applications in periodontics, emphasizing the importance of continual advancements and …

Journal Ida 2025 104 3

Journal IDA

In the Summer 2025 issue, the reader will find the following feature articles:

• Dental Sticky Situations
• Defining Prescriptive Supervision and Delegation in Indiana: The Essential Roles of the Dental Hygienist and the Dental Assistant on the Dental Team
• Safeguarding Ethics: The Work of the Indiana State Board of Dentistry
• Dental Treatment: Who Has the Final Say on Oral Health Care?
• Overview of Indiana Health Records Law
• Ethical Considerations in Cosmetic Dentistry
• Protecting Dentistry’s Ethics: IDA’s Peer Review Program
• An Annotated Walkthrough of Dental and Dental Hygiene Professional Oaths Using AI Search Engines
• Radiation Safety in Dental Offices: Where Do We …

Journal Ida 2022 101 3

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.

Journal Ida 2022 101 1

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.

Journal Ida 2021 100 2

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.

Journal Ida 2020 99 4

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.

Journal Ida 2020 99 2

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.

Journal Ida 2019 98 4

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.

Journal Ida 2019 98 2

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.

Distribution Of Urinary Calculi And Its Association With Clinical And Laboratory Findings In Dogs And Cats With Stone Analysis At Chulalongkorn Animal Teaching Hospital, Thailand (2020-2024), Tanattha Ladabornvidhaya, Natkrita Baikloy, Theaparak Thipjaroen, Parapond Kongrakchang, Warisara Kaechaiya, Sumonwan Chamsuwan, Monkon Trisiriroj, Chollada Buranakarl

The Thai Journal of Veterinary Medicine

Urinary calculi are commonly encountered in veterinary practice; however, information regarding their distribution of stone that underwent analysis and associated clinical findings remains limited. This study investigated the distribution of urolithiasis and the associations between stone types and clinical and laboratory findings in dogs and cats presented to the Chulalongkorn Small Animal Teaching Hospital between 2020 and 2024. The three most common stone types in both species were calcium oxalate (CaOx), struvite, and urate, with relatively stable trends over the 5-year period. Small-breed dogs had a higher risk of developing CaOx urolithiasis than medium-breed dogs (OR = 10.4, 95% CI …

A Review On Traditional And Modern Aspects Of Vitex Negundo L.: Ethnomedicine, Phytochemistry, And Pharmacology, Tathagata Khanra, Suvasish Mitra, Subham Saha, Maitryee Mondal, Subhash C. Mandal

International Journal of Traditional Knowledge

Vitex negundo L., or five-leaved chaste tree, is a medicinally significant plant widely distributed in Asia and other tropical regions, frequently utilized in traditional healing systems for a spectrum of ailments. This comprehensive review consolidates current knowledge on the botany, traditional uses, phytochemical constituents, and pharmacological potentials of Vitex negundo L. The plant is rich in diverse bioactive compounds such as flavonoids, alkaloids, glycosides, and terpenoids, which are primarily responsible for its multidimensional therapeutic actions. Scientific investigations have substantiated its role in exerting anti-inflammatory, analgesic, antimicrobial, antioxidant, hepatoprotective, nephroprotective, insecticidal, anticancer, and antidiabetic effects, among others. Research reveals promising enzyme-inhibitory, …

Siddha Formulations: A Traditional Reservoir Of Valuable Medicines For The Contemporary World, Agnes Preethy

International Journal of Traditional Knowledge

Traditional Medicine had been practised for many centuries in different parts of the world. However, the deep insights drawn from the traditional knowledge have remained highly localized as it had been privy only to the generations of traditional medicine practitioners. This, combined with lack of scientific evidence of their therapeutic action, had limited access, acceptance and awareness of these preparations to the larger segment of the community. The emergence of new lifestyle disorders and drug-resistant diseases in recent years has fuelled the search for alternate treatment strategies and has revived interest in traditional medicines. Concerted efforts to decipher the molecular …

Ayurvedic Herbs In The Management Of Benign Prostatic Hyperplasia: A Comprehensive Narrative Review, Latha Damle, Chandrasekhar C

International Journal of Traditional Knowledge

Benign Prostatic Hyperplasia (BPH) is a common, non-cancerous enlargement of the prostate gland, primarily affecting older men. It frequently leads to lower urinary tract symptoms (LUTS) such as increased urinary frequency, urgency, nocturia, and weak urine flow, which can significantly impair quality of life. Standard treatments for BPH include alpha-blockers, 5-alpha reductase inhibitors, and surgical interventions. However, limitations in efficacy and potential adverse effects have driven interest in complementary and traditional therapies, including Ayurveda. In Ayurvedic medicine, BPH is described as Mutraghata and Vatashthila, conditions attributed to an imbalance of Vata and Kapha doshas that disrupt normal prostate and …

Unveiling The Night-Flowering Jasmine: A Comprehensive Review Of Nyctanthes Arbor-Tristis’ (Oleaceae) Phytochemistry, Ethnomedicine, And Therapeutic Potential, Subham Saha, Soumya Mitra, Tathagata Khanra, Saban Karmakar, Tamalica Hore, Subhash C. Mandal

International Journal of Traditional Knowledge

Nyctanthes arbor-tristis (NAT), typically known as Night-flowering Jasmine or Harsingar or Parijat, is one of the prominent medicinal plants indigenous to the Indian subcontinent. Its application dates back to ancient times, with substantial documentation in former religious texts. Native communities have traditionally used this for various human ailments and as an ornamental plant. Leaves, flowers, seeds and stems of this plant are rich in various primary and secondary metabolites, providing a wide range of pharmacological effects. The most abundantly found phytoconstituents belong to iridoid glycosides, such as arbortristosides. Comprehensive research has investigated its potential in anticancer, antiviral, and anti-inflammatory activities, …

Gaining From Captured Indian Traditional Knowledge Systems: Paths Taken And Way Forward, Ramasami T

International Journal of Traditional Knowledge

India’s scientific heritage is deeply reflected in Ayurveda, a tradition of integrative medicine documented for over two millennia. P.C. Ray, the father of modern chemistry in India, highlighted the depth of ancient chemical knowledge and early use of mercury compounds, while M.S. Valiathan later revived and analyzed the classical texts of Charaka, Sushruta, and Vagbhata to bridge Ayurveda with modern science. Building on this foundation, the Government of India launched initiatives linking Ayurveda with genomics, personalized medicine, and rasayana therapies, yielding promising insights such as the genetic basis of prakriti classifications and protective effects of Amalaki Rasayana. Efforts like the …

Altered Postnatal Chromatin Development In The Nucleus Accumbens Primes Enduring Stress Sensitivity, Rebekah L Rashford, Lisa Z Fang, Michael Deberardine, Hye Ji J Kim, Laura W Hirschfield, Ella Cervi, Mason R Barrett, Jeremy M Thompson, Meaghan C Creed, Catherine Jensen Peña

2020-Current year OA Pubs

Early life stress (ELS) sensitizes individuals to subsequent stressors to increase lifetime risk for psychiatric disorders. Within the nucleus accumbens (NAc)-a key limbic and reward-associated brain region-ELS sensitizes both cellular and transcriptional response to later stress, which are programmed by enduring epigenetic changes. Among the histone modifications persistently enriched by ELS in NAc is H3K4me1, which is associated with open chromatin and epigenetic priming of genomic enhancers. Here, we sought to determine whether H3K4me1 enrichment in NAc was sufficient to prime cellular and behavioral responses to adult stress. Viral-mediated overexpression of the histone H3 monomethyltransferase

Translational Initiative To Minimize Childhood Hemiparesis After Asymmetrical Perinatal Brain Injury, Susan V. Duff, Emily Garavatti, Terrie Inder

Physical Therapy Faculty Articles and Research

The purpose of this perspective paper is to present a translational approach aimed at identifying the critical periods in brain development during which to provide neuroprotective and neurorestorative strategies, followed by prehensile training, to minimize hemiparesis and foster skill acquisition after asymmetrical perinatal brain injury (APBI). We contend that hemiparesis could be minimized after APBI through a multimodal sequential approach based on timely implementation of evidence-based intervention strategies. If APBI is identified early, neuroprotective techniques can be used in the first 10 days of life to minimize cell death. This can be followed in the next 3 months by the …

Heritable Transgenic Schistosomes As A Living Platform For Sars-Cov-2 Neutralizing Antibody Secretion, Wannaporn Ittiprasert, Bruce A Rosa, Sergej Djuranovic, Makedonka Mitreva, Et Al.

2020-Current year OA Pubs

We report the generation and propagation of not only the first heritable transgenic schistosome line but also a line that secretes a functional therapeutic protein in vivo. Using multiplexed CRISPR/Cas-mediated homology-directed knock-in targeted to a predicted genomic safe-harbor, we inserted a VHH-IgG1 Fc (termed C5-Fc) transgene into Schistosoma mansoni eggs. Single-miracidium infections of Biomphalaria glabrata yielded parental P0 lines; serial passage through snail and mouse hosts produced an F2 cohort in which all parasites carried the C5-Fc transgene and secreted C5-Fc into the murine venous circulation. Molecular assays confirmed chromosomal insertion, germline transmission and systemic secretion. Sera from mice harboring …

Retrieval Strategies For Embolized Left Atrial Appendage Closure Devices, Usama Sadiq, Muneeba Ali, Stacey Damito, Maxwell Ambrosino, Muhammad Sabri, Muhammad Ahmad Sadiq, Muhammad Hamza Sadiq, Richard Kovach, Sheena Rastogi, Muhammad Raza

Abington Jefferson Health Papers

BACKGROUND: Device embolization (DE) is a rare but potentially life-threatening complication of left atrial appendage occlusion (LAAO). As landmark trials broaden the eligible population for LAAO, operator preparedness for DE management becomes increasingly critical.

CASE SUMMARY: We present 4 cases of LAAO DE managed with distinct retrieval strategies: 1) open surgical retrieval with concurrent AtriClip ligation for an endothelialized left atrial device; 2) sequential transseptal then retrograde arterial snaring for intraprocedural migration to the abdominal aorta; 3) transseptal retrieval using a dedicated ONO system with cerebral embolic protection for partial left atrial dislodgment; and 4) retrograde large-bore arterial retrieval for …

Redo-Transcatheter Aortic Valve Replacement With Self-Expanding Valves: A U.S. Registry Analysis., Toby Rogers, Vinayak N Bapat, Stanley J Chetcuti, Harold L Dauerman, John K Forrest, Sachin S Goel, Kendra J Grubb, Wah Wah Htun, Rishi Puri, Michael J Reardon, Gilbert H L Tang, Amit N Vora, Steven J Yakubov, Ruth Eisenberg, Guilherme F Attizzani

Heart and Vascular Articles

BACKGROUND: Redo-transcatheter aortic valve replacement (TAVR) for failed transcatheter heart valves is expected to increase, but data on outcomes with self-expanding valves remain limited.

OBJECTIVES: The aims of this study were to evaluate procedural, clinical, and quality-of-life outcomes following redo-TAVR using self-expanding Evolut valves and to compare these outcomes with those among a contemporary native TAVR cohort.

METHODS: Outcomes after redo-TAVR with Evolut R, Evolut PRO, and Evolut PRO+ valves in the Society of Thoracic Surgeons/American College of Cardiology TVT (Transcatheter Valve Therapy) Registry were analyzed and compared with outcomes after native-valve TAVR using the same valve platform during the …

New Frontiers In Diagnosing Equine Lameness, Hyrum Hoopes, Karl Hoopes

All Current Publications

Lameness is one of the most common and expensive health problems seen in horses. Modern technology allows veterinarians to look beneath the surface. Tools such as artificial intelligence (AI), computed tomography (CT), magnetic resonance imaging (MRI), digital radiography (X-rays), nuclear scintigraphy, ultrasound, and positron emission tomography (PET) give clearer, more detailed pictures of what’s happening inside the horse’s leg. Each technology offers different advantages, from identifying uneven movement to revealing hidden damage within bones, joints, or soft tissues. When combined with veterinary visual evaluation, they help pinpoint the cause of lameness faster and more accurately than ever before.

Mean Platelet Volume As A Marker Of Disease Severity In Hospitalized Children With Acute Bronchiolitis., Kedar Tilak, Trisha Sunderajan, Lewis Krata

Manuscripts, Articles, Book Chapters and Other Papers

Bronchiolitis is one of the most common lower respiratory tract infections affecting children less than two years of age and is a leading cause of hospitalization. Mean platelet volume (MPV), a readily available component of the complete blood count, has been investigated as an inflammatory biomarker in various conditions. Our present study evaluated the association between MPV values and the severity of acute bronchiolitis in hospitalized children.    Objective: The aim of this study was to determine the association between MPV, severity of respiratory distress, and need for oxygen support in hospitalized children under two years of age with acute bronchiolitis. …

A Four-Year Analysis Of #Orthotwitter Use During Match Week: Can X Be A Potential Equalizer For Students Left Unmatched?, Desiree E Ojo, Davis Hedbany, Brook Willett, Brandon D Rust, Geoffrey Deckard, Omar Guerrero, Jalen Warren, Michael Megafu, Morgan Turnow, Jaime Bellamy

Medical Education Articles

Background The orthopedic surgery match has changed. Since the COVID-19 pandemic, orthopedic surgery candidates and residency programs have used #Orthotwitter to promote, advocate, and educate their followers. This study aimed to evaluate changes in the use of #OrthoTwitter and #OrthoMatch during Match Week over a four-year period, including trends in author type, post content, institutional affiliation, engagement, and posting activity, with particular attention to posts involving unmatched applicants. Methodology The top tweets containing the hashtags #Orthotwitter and/or #OrthoMatch during the 2021, 2022, 2023, and 2024 Match Week were reviewed and collected. Tweets between the years 2021, 2022, 2023, and 2024 …

Minimally Invasive Percutaneous Endoscopic Foraminotomy And Discectomy In A French Bulldog With Intervertebral Disc Extrusion, Tanhatai Krajarngjang, Luksamee Limpongsai, Panutda Darapong, Woraphanit Sonbanpai, Mataya Taweechart

The Thai Journal of Veterinary Medicine

A six-year-old female French Bulldog was referred for neurological diagnostic tests and treatment for progressive paraparesis over an 8-day period. The dog had a history of intervertebral disc extrusion (IVDE) surgical correction two years prior. Neurological examination revealed T3–L3 myelopathy. Magnetic resonance imaging of the thoracolumbar spine confirmed IVDE with spinal cord compression at T13–L1. A minimally invasive percutaneous endoscopic foraminotomy and discectomy (PEFD) was performed to remove the extruded disc material. The patient regained the ability to stand and showed voluntary limb movement 48 hours post-surgery. At the 4-week follow-up, the patient showed a complete recovery to her baseline …

Cells And Networks In Flux: Rethinking Ontogenesis And Pathogenesis, Mark L. Tykocinski

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Organ and tissue functions emerge from the coordinated activity of cell networks. Therapeutics that act on pathogenic cell networks, modulating their cellular interplay, follow naturally. Over several decades, our laboratory has developed a series of approaches for rewiring cell networks, culminating in a class of cell surface-directed signal converter proteins (SCPs) that do so by modulating juxtacrine and autocrine signaling in and among their nodal cells. A first such SCP has now produced encouraging clinical data for cancer immunotherapy. Yet, these early network-directed fusion proteins rest on a deliberately simplified picture: discrete end-cell types plugged into graphically tractable networks. That …

Nascent Adam17 Synthesis Potentiates Gpibα Cleavage In Resting And Stimulated Stored Platelets, Shayan Askari, Harriet Ghansah, Christopher D. Mansi, Timothy J. Stalker, Lawrence E. Goldfinger

Cardeza Foundation for Hematologic Research

Platelet concentrates stored at room temperature have a shelf life of 5 to 7 days. During storage, platelets undergo glycoprotein cleavage by metalloproteases, notably cleavage of glycoprotein Ibα (GPIbα) by a disintegrin and metalloprotease 17 (ADAM17), which leads to decreased posttransfusion reactivity and recovery. To investigate the putative roles of nascent synthesis of ADAM17 in GPIbα shedding and platelet function during room temperature platelet storage. Human platelets maintained in autologous plasma were treated with naked endonuclease-resistant ADAM17 or control short inhibitory RNA (siRNA) and monitored for molecular and cellular effects during storage. Platelet-specific Adam17-deleted mice were generated, and the dynamics …

Selective Loss Of Primary Cilia And Neurotrophic Signaling In G51d Α-Synuclein Mice Highlights A Common Pathway To Parkinson’S Disease, Yu-En Lin, Ebsy Jaimon, Youngdoo Kim, Annabeth Loftman, Aaran Vijayakumaran, Benjamin D W Belfort, Claire Y Chiang, Benjamin R Arenkiel, Huda Y Zoghbi, Suzanne R Pfeffer

Duncan NRI Faculty and Staff Publications

Parkinson's disease is characterized by dopaminergic neuron loss and accumulation of α-synuclein aggregates in the brain. G51D α-synuclein knock-in mice provide a genetically and clinically relevant model of disease, exhibiting early olfactory deficits, age-dependent motor impairment, and progressive phospho-α-synuclein accumulation. In multiple Parkinson's disease models, striatal cholinergic and parvalbumin interneurons, as well as astrocytes, lose primary cilia and the neurotrophic signaling needed to sustain dopaminergic neurons. We show here that G51D α-synuclein mice share these phenotypes. Phospho-Ser129 α-synuclein accumulation correlates with cilia loss in cholinergic interneurons but not in spiny projection neurons that accumulate higher phospho-α-synuclein levels. In the piriform …

Acemannan/Alginate Composite Hydrogels Promote Sto Cell Spreading And Metabolic Activity, Hong Yongxing, Tharasanit Theerawat

The Thai Journal of Veterinary Medicine

Alginate-based hydrogels are widely used as biocompatible scaffolds. However, their limited cell-adhesive properties restrict their application in tissue engineering. This study aimed to fabricate acemannan/alginate (ACE/ALG) composite hydrogels and evaluate their cytocompatibility and ability to support STO cell spreading and metabolic activity. Composite hydrogels were prepared by blending different concentrations of ACE with alginate, followed by Ca²⁺-mediated ionic crosslinking. Rheological analysis showed that ACE incorporation increased both the storage modulus (G′) and loss modulus (G″) of the hydrogels. Cell viability and morphology were evaluated using Live/Dead staining on day 7, and cellular growth was assessed using an MTT assay on …

Multidrug Resistance, Extended-Spectrum Β-Lactamase (Esbl) Production, And Colistin Resistance In Escherichia Coli From Retail Chicken Meat In Fresh Markets In Bangkok, Thailand, Htet Lin Oo, Nawaphorn Roongrojmongkhon, Suwanee Chalermchainukul, Sirawit Pagdepanichkit

The Thai Journal of Veterinary Medicine

Contamination of chicken meat with antimicrobial-resistant bacteria, particularly multidrug-resistant (MDR), colistin-resistant, and extended-spectrum β-lactamase (ESBL)-producing Escherichia coli (E. coli), threatens its safety for human consumption. This study was conducted to determine the prevalence and antimicrobial resistance (AMR) profiles, particularly ESBL production and colistin resistance in E. coli isolated from retail chicken meat in fresh markets in Bangkok, Thailand. A total of 200 (81.6%) E. coli isolates were recovered from 245 chicken meat samples collected from fresh markets across six regions of Bangkok. Among the isolates, 189 (94.5%) exhibited resistance to at least one antimicrobial agent tested, with the …