Digital Commons Network^™

Ua12/4 Commuter Link, Vol. 1, No. 1, Wku Health Services

WKU Administration Documents

Newsletter created for non-traditional students returning to WKU.

How To Make A Blastocyst., A J Watson, G M Kidder, G A Schultz

Obstetrics & Gynaecology Publications

Several of the new reproductive technologies have been cultivated from our current understanding of the genetic programming and cellular processes that are involved in the major morphogenetic events of mammalian preimplantation development. Research directed at characterizing the patterns of gene expression during early development has shown that the embryo is initially under maternal control and later superseded by new transcriptional activity provided by the activation of the embryonic genome. Several embryonic transcripts encoding: (i) growth factors, (ii) cell junctions, (iii) plasma membrane ion transporters, and (iv) cell adhesion molecules have been identified as contributing directly to the progression of the …

Loma Linda Nurse - Vol. 03, No. 01, Loma Linda University School Of Nursing

Loma Linda Nurse

Contents

2 | Message from the dean

3 | School of Nursing celebrates graduation

3 | House of Thrift brings out volunteer spirit

5 | Alumna wins Jessie M. Scott award

6 | Annual awards chapel

6 | Class of 1992

6 | Class of 1967

7 | Advancement

9 | Donor List

15 | Message from the president

16 | Memo

17 | Bylaws

20 | Near and Far

Sex Selection: Regulating Technology Enabling The Predetermination Of A Child's Gender, Owen D. Jones

Vanderbilt Law School Faculty Publications

The debate over the prohibition of sex (or gender) selection (also known as "preselection" or "predetermination"), has focused almost exclusively on the context of aborting a "wrong-sex" fetus after a fetal gender-identification procedure. Despite the fact that sex selection abortions represent only a small subset of sex selection procedures, attitudes toward the former are driving general policy approaches to the latter. However, the issues are analytically distinct, and only during the former infancy of the pre-conceptive (and non-abortive post-conceptive) technology for sex selection were members on both sides of the debate afforded the economy of using one logic to support …

Changes In Intracellular Chloride During Osmotic Stress And L-Alanine Uptake In Mouse Hepatocytes, Kening Wang

Electronic Theses and Dissertations

A stable intracellular ionic environment is necessary for hepatocytes to function normally. Thus, during hypotonic shock or L-alanine uptake, hepatocytes swell and then exhibit a regulatory volume decrease (RVD), which comprises an increase in K$\sp+$ conductance (G$\sb{\rm K}$), an increased K$\sp+$ efflux, and a hyperpolarization of transmembrane potential (V$\sb{\rm m}$). Since hepatocyte intracellular Cl$\sp-$ has been demonstrated to distribute passively with V$\sb{\rm m}$, this study is designed to test the hypothesis that the hypotonic shock- or L-alanine uptake-induced hyperpolarization of V$\sb{\rm m}$ might provide an electromotive force for the efflux of hepatocyte intracellular Cl$\sp-$, which in turn would contribute osmotically …

The Effects Of Post-Event Massage Therapy On Multistage Ultraendurance Cycling, Tracey Hodges Drews

Human Movement Studies & Special Education Theses & Dissertations

Post-event massage therapy has been proposed to hasten muscle recovery and improve ensuing performance in multistage ultraendurance cycling events. Six elite male cyclists competed in two 4·d stage races of 161 kmd^·1 on a computerized race simulator over challenging terrain in a controlled laboratory environment with an average completion time of 275 ± 28 min. In a crossover experimental design, subjects received either 30 min post-event massage therapy or a 30 min inactivated diathermy treatment serving as a blind placebo after each 161 km race. The subjects repeated the 4·d, 161 km·d^·1 event 18d later receiving alternate post-event …

Red Butte Canyon Research Natural Area: History, Flora, Geology, Climate, And Ecology, James R. Ehleringer, Lois A. Arnow, Ted Arnow, Irving B. Mcnulty, Norman C. Negus

Great Basin Naturalist

Red Butte Canyon is a protected, near pristine canyon entering Salt Lake Valley, Utah. It contains a well-developed riparian zone and a perennial stream; hillside vegetation ranges from grasslands on the lower limits to Douglas-fir and aspen stands at the upper elevations. In this paper we describe the history of human impact, natural history aspects of climate, geology, and ecology, and faunal and floral information for key species in the canyon. The role and importance of Research Natural Areas is discussed, particularly with respect to the need to protect Red Butte Canyon—one of the few remaining undisturbed riparian ecosystems in …

One-Trial Backward Excitatory Fear Conditioning Transfers Across Contexts, Rick A. Bevins, John J. B. Ayres

Department of Psychology: Faculty Publications

One path to human phobia may be one-trial backward fear conditioning. Human phobias transfer readily across contexts. However, animal studies of one-trial backward fear conditioning have yet to demonstrate such transfer. The present study sought to do so. It used a lick-suppression procedure with 84 naive male albino rats. Two conditioning contexts, designated O and V, were crossed factorially with two test contexts, O and V. Within each cell of the factorial design, rats received in the conditioning context either a single 12 sec tone backward paired with a single 4 sec 1 mA shock or the same tone explicitly …

Dentalgram - Vol. 06, No. 09, Loma Linda University School Of Dentistry

Dentalgram

In this issue:

• Annual Fund goal exceeded
• New residents in endodontics
• Student reflections on Sabbath retreat
• Student volunteers recognized by ADA
• New journals at library
• Upcoming graphic slide seminar
• New dental Sabbath school schedule
• Blood drive update

Patterns Of Neoplasia In C-Mos Transgenic Mice And Their Relevance To Multiple Endocrine Neoplasia, Nicholas Schulz, Friedrich Propst, Michael M. Rosenberg, R. Ilona Linnoila, Richard S. Paules, Douglas Schulte, George F. Vande Woude

Henry Ford Hospital Medical Journal

We have previously described a neurological phenotype for transgenic mice carrying the c-Mos proto-oncogene. Pheochromocytomas and C-cell thyroid neoplasms occur in these transgenic lines in patterns that are similar to those seen in multiple endocrine neoplasia type 2 (MEN 2). Characterization of the pathological lesions via immunohistochemistry underscores similarities between MEN 2 and these transgenic mice. When transgenic mice that do not display the MEN 2 phenotype are crossed to a different background, the progeny display the MEN 2 phenotype. Thus the interaction of the background with the transgene is such that it can suppress tumor information. This observation bears …

Parathyroid Tumor Biology In Familial Multiple Endocrine Neoplasia Type 1: A Model For Cancer Development, Maria Luisa Brandi

Henry Ford Hospital Medical Journal

Familial multiple endocrine neoplasia type 1 (FMEN 1) is an autosomal dominant disorder characterized by tumors of the parathyroid glands, pancreatic islets, and anterior pituitary. Hyperplasia appears to be the typical histopathological lesion in FMEN 1 endocrine tumors. A circulating mitogen related to basic fibroblast growth factor was active on proliferation of clonal bovine and human parathyroid endothelial cells. Moreover, the FMEN 1 mitogen modulated differentiation of human parathyroid endothelial cell in vitro. All these facts suggested that an extrinsic factor was active on parathyroid endothelial cell growth and differentiation. The FMEN 1 gene maps to chromosome 11q13, and allelic …

Biologic And Cytogenetic Characterization Of Three Human Medullary Thyroid Carcinomas In Culture, R. Pfragner, G. Wirnsberger, A. Behmel, B. Niederle, F. Längle, R. Roka, A. Mandl, P. Pürstner, J. Auner, F. Tatzber

Henry Ford Hospital Medical Journal

Neuroendocrine features and cytogenetic abnormalities of one continuous cell line (MTC-SK) and two long-term cultures (GER, STAH) derived from three sporadic cases of human medullary thyroid carcinomas (MTCs) were studied. Specific neuroendocrine markers (NSE, chromogranins, calcitonin, calcitonin gene-related peptide) were identified by electron microscopy and immunocytochemistry. In situ hybridochemistry and Northern blot analysis confirmed endocrine activity. Cytogenetic studies of the cell line MTC-SK revealed three consistent marker chromosomes, t(3;10), 11p+, and 22p+. Cells of long-term cultures GER and STAH exhibited a consistent translocation t(2;18), a trisomy 7, and two consistent marker chromosomes der3 and 5p+, respectively. Recently, we have isolated …

Gelatinase Activity In The Mouse Uterus During Early Pregnancy, Carol A. Brenner, Richard R. Adler, Gary L. Nieder

Neuroscience, Cell Biology & Physiology Faculty Publications

No abstract provided.

Yoghurt (Dahi): A Probiotic And Therapeutic View, Z Abbas, W Jafri

Section of Gastroenterology

No abstract provided.

On The Mechanism Of Parathyroid Hormone Stimulation Of Calcium Uptake By Mouse Distal Convoluted Tubule Cells, F A. Gesek, A. Friedman

Dartmouth Scholarship

PTH stimulates transcellular Ca2+ absorption in renal distal convoluted tubules. The effect of PTH on membrane voltage, the ionic basis of the change in voltage, and the relations between voltage and calcium entry were determined on immortalized mouse distal convoluted tubule cells. PTH (10(-8) M) significantly increased 45Ca2+ uptake from basal levels of 2.81 +/- 0.16 to 3.88 +/- 0.19 nmol min-1 mg protein-1. PTH-induced 45Ca2+ uptake was abolished by the dihydropyridine antagonist, nifedipine (10(-5) M). PTH did not affect 22Na+ uptake. Intracellular calcium activity ([Ca2+]i) was measured in cells loaded with fura-2. Control [Ca2+]i averaged 112 +/- 21 nM. …

Antibodies Against Epstein-Barr Nuclear Antigen (Ebna) In Multiple Sclerosis Csf, And Two Pentapeptide Sequence Identities Between Ebna And Myelin Basic Protein., Patrick F. Bray, J Luka, Paul F. Bray, K W. Culp, J P. Schlight

Cardeza Foundation for Hematologic Research

The Epstein-Barr virus (EBV) causes infectious mononucleosis and is linked to several disparate malignancies. Prior studies on patients with multiple sclerosis (MS) showed that 100% are EBV-seropositive and that their blood contains higher antibody titers than those of controls to both transformation and lytic cycle antigens. We performed three different assays for antibodies in CSF to three major EBV antigens from patients with MS and controls. Among 93 patients with MS, 79 (85%) had CSF that reacted with a 70 kD protein, shown to be the nuclear antigen, EBNA-1, whereas only 11 (13%) of 81 EBV-seropositive controls reacted, p less …

Menno-Knight, September 1992, Mennonite College Of Nursing

Menno-Knight (1960s-1990s?)

Student newsletter of the Mennonite School/College of Nursing.

What's Happening: August 26, 1992, Maine Medical Center

What's Happening

No abstract provided.

Dentalgram - Vol. 06, No. 08, Loma Linda University School Of Dentistry

Dentalgram

In this issue:

• School of Dentistry retreat is upon us
• DH surpasses fund-raising goal
• Join new dentistry Sabbath school
• Japanese educators visit Loma Linda
• Researchers return from Scotland
• Lock your clinic carts
• Handpieces to be sterilized between each patient
• Dental employee wins travel certificate
• Give blood at School blood drive

Effects Of Dextro-Methamphetamine On Subjective Fatigue, C. A. Dejohn, Scott Shappell, D. F. Neri

Publications

Declining aircrew performance during periods of sustained flight operations (SUSOPs) has underscored the need to develop effective countermeasures. This paper reports on the ability of the central nervous system (CNS) stimulant d-methamphetamine to alleviate the detrimental effects of a simulated SUSOPs on subjective fatigue. Subjective fatigue was repeatedly measured by three questionnaires. The simulated SUSOP started at 1800 and consisted of a 9-h planning session followed by 4 h of rest and a 14-h mission. After 6 h of sleep, the 9/4/14 work/rest/work pattern was repeated. At 4 1/2 h into the second mission, 13 subjects were administered 10 mg …

Development Of Periapical Lesions In Immunosuppressed Rats, Phillip A. Waterman Jr.

Loma Linda University Electronic Theses, Dissertations & Projects

The pathogenesis of periapical lesions is the interaction of the oral flora with the existing host defenses. The role of bacteria has been established in endodontic disease but the contribution of the host defenses in periapical lesion formation is less clear. The purpose of this study was to compare periapical lesion development in immunosuppressed rats with that in normal rats. Thirty-five, eight-week old Sprague-Dawley rats were equally divided into seven groups. Groups 1, 2, and 3 were given weekly injections of Cytoxan, an immunosuppressive agent. Groups 4, 5, and 6 received no immunosuppressive therapy. Group 7 served as a control, …

Transforming Growth Factor-Beta 1 Expression In Developing Ovine Teeth As Visualized By In Situ Hybridization, Søren Jepsen

Loma Linda University Electronic Theses, Dissertations & Projects

Recently we demonstrated that human dentin contained relatively high amounts of transforming growth factor beta (TGF-ß) and proposed that dentin TGF-ß originated from odontoblasts. Because of the suggested role of TGF-ß in mediating cellular interactions in dental cell development by paracrine mechanisms, we studied the expression of TGF-ß message in developing teeth by in situ hybridization. 5 µm serial sections of neonatal sheep mandibular third molars that had been fixed in glutaraldehyde and paraffin-embedded were used for in situ analysis. An [³⁵S]-labeled cRNA probe, complementary to TGF-ß1 mRNA, was constructed from human TGF-ß1 cDNA. Northern analysis of total …

Relationship Satisfaction As A Function Of The Discrepancy Between Experienced And Desired Levels Of Intimacy, Joan I. Malcolm

All-Inclusive List of Electronic Theses and Dissertations

The present study investigated the effect of discrepancies between experienced versus desired levels ·of intimacy on relationship satisfaction using data from 13§ undergraduate students. Subjects completed the Personal Assessment of Intimacy in Relationships (PAIR), the Dyaqic Relationship Questionnaire (DRQ), the Dyadic Adjustment Scale (DAS), and a Background Questionnaire (BQ). Correlation and multiple regression analyses indicated that discrepancies between Desired and Experienced Intimacy, as measured by the PAIR and DRQ, was highly predictive of relationship satisfaction, as measured by the DAS. However, Experienced Intimacy was a better predictor of relationship satisfaction. Both males and females ranked Emotional Intimacy as most important …

Mechanism Of Calcium Transport Stimulated By Chlorothiazide In Mouse Distal Convoluted Tubule Cells., Frank A. Gesek, Peter A. Friedman

Dartmouth Scholarship

Thiazide diuretics inhibit Na+ and stimulate Ca2+ absorption in renal distal convoluted tubules. Experiments were performed on immortalized mouse distal convoluted tubule (MDCT) cells to determine the mechanism underlying the dissociation of sodium from calcium transport and the stimulation of calcium absorption induced by thiazide diuretics. Control rates of 22Na+ uptake averaged 272 +/- 35 nmol min-1 mg protein-1 and were inhibited 40% by chlorothiazide (CTZ, 10(-4) M). Control rates of 36Cl- uptake averaged 340 +/- 50 nmol min-1 mg protein-1 and were inhibited 50% by CTZ. CTZ stimulated 45Ca2+ uptake by 45% from resting levels of 2.86 +/- 0.26 …

Fixed-Ratio Size As A Determinant Of The Development Of Tolerance To Morphine, Mark J. Nickel

Masters Theses

The acute and chronic effects of morphine were examined in pigeons exposed to a multiple schedule with fixed ratio 5, 25, and 125 components. Acute exposure to morphine (0.56-10.0 mg/kg) resulted in rate reductions under each component when the dose was 1 mg/kg or higher. With chronic exposure to 5.6 mg/kg, tolerance to the rate-reducing effects of morphine was evident under each fixed ratio component. The development of tolerance was determined to some extent by fixed-ratio size, a result similar to earlier findings with cocaine.

Retrofilling Materials : The Effects Of Two Setting Times On The Degree Of Dye Leakage Of Retrograde Filling Materials, Robert K. Higa

Loma Linda University Electronic Theses, Dissertations & Projects

Sealing of the root canal system is usually accomplished by the conservative endodontic approach. Cases where it is impossible to treat nonsurgically are usually treated surgically by an apicoectomy and retrofill. There is a lot of controversy in the literature over which retrofilling material is closest to ideal. Presently, the most popular materials seem to be Amalgam, Super EBA, and IRM. For this reason, these materials were chosen for this study to evaluate the leakage potential at two different time intervals to see if setting time of the material had any influence on the amount of leakage.

Seventy extracted single …

F Response Frequency For The Median And Ulnar Nerves In A Normal Population, Patricia J. Killea

Rehabilitation Sciences Theses & Dissertations

The F wave or F response results form the recurrent discharge of antidromically activated anterior horn cells. F response latency represents an impulse which travels to and from the spinal cord through the central segment of a nerve. Study of the F wave is commonly done to assess proximal conduction in motor nerves, to measure motor nerve conduction velocity over a longer pathway than in orthodromic motor studies, and to assess motor neuron excitability. F response characteristics less commonly studied include duration, chronodispersion, shape, amplitude, and frequency. The primary purpose of this study was to determine F response frequencies of …

What's Happening: July 29, 1992, Maine Medical Center

What's Happening

No abstract provided.

What's Happening: July 15, 1992, Maine Medical Center

What's Happening

No abstract provided.

What's Happening: July 1, 1992, Maine Medical Center

What's Happening

No abstract provided.