Digital Commons Network^™

Statement On Exercise: Benefits And Recommendations For Physical Activity Programs For All Americans - A Statement For Health Professionals By The Committee On Exercise And Cardiac Rehabilitation Of The Council On Clinical Cardiology, American Heart Association, Gerald F. Fletcher, Steven N. Blair, James Blumenthal, Carl Caspersen, Bernard Chaitman, Stephen Epstein, Harold Falls, Erika S. Sivarajan Froelicher, Victor F. Froelicher, Ileana L. Piña

Faculty Publications

No abstract provided.

Jefferson Alumni Bulletin – Volume Xli, Number 4, Summer 1992

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLI, Number 4, Summer 1992

Malignant bone tumors developing at sites of benign preexisting bone disease, page 13

An experience with a small rural hospital, page 15

The prevention of Turista and the enjoyment of foreign travel, page 16

The Nemours children’s clinic, page 17

The shoulder revisited, page 19

Jeff’s trauma program, page 20

The biochemical basis for diabetic nephropathy, page 21

Dealing with the media, page 23

Space motion sickness, page 24

Total joint replacement, page 25

Decision making and the doctor-patient relationship, 26

New endowed chair, page 30

Inaugural grandon lecture, page …

Department Of Radiology-Annual Report-July 1, 1991 To June 30, 1992, David C. Levin

Department of Radiology Administrative Documents and Reports

Department of Radiology Annual Report, July 1, 1991 to June 30, 1992. Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States. 72 pages.

What's Happening: June 17, 1992, Maine Medical Center

What's Happening

No abstract provided.

Motivational Effects On A Psychometric Measure Of Prefrontal Brain Functioning In Patients With Chronic Schizophrenia And Related Disorders, Paul C. Smith

Dissertations

This study compared multiple sequential performances on a computerized version of the Wisconsin Card Sorting Test (Grant & Berg, 1948; Harris, 1986) by adult men receiving institutional inpatient treatment for chronic schizophrenia and related disorders. Participants were exposed to differential test conditions of minimal post-session non-contingent token reinforcement (baseline phases) and enhanced intra-session performance-contingent token reinforcement (experimental phase). Each major participant resided at the same continuing treatment unit at Kalamazoo Regional Psychiatric Hospital receiving similar social therapies but idiosyncratic psychotropic medication regimens, changes in which were tracked in relation to test performances. A simple single-subject reversal design was employed with …

Dimarco V. Lynch Homes-Chester County, Inc.: How Far Should West Virginia Go In Extension Of Physician Liability For Transmission Of Communicable Disease, Rebecca Coffield Moore

West Virginia Law Review

No abstract provided.

Dentalgram - Vol. 06, No. 06, Loma Linda University School Of Dentistry

Dentalgram

In this issue:

• Commencement report
• Senior candids
• School of Dentistry has new Sabbath school
• ReTREAT plans unfold
• New signs for Prince Hall
• Students to spend summer in mission outreach
• Students conduct committee reports
• Department faculty busy
• Library has new serials, book
• LSU holding business seminar
• Alumni request help

Immune Responses Of Systemic And Mucosal Lymphoid Organs To Pnu-Imune Vaccine As A Function Of Age And The Efficacy Of Monophosphoryl Lipid A As An Adjuvant, Manju Garg, Subbarao Bondada

Microbiology, Immunology, and Molecular Genetics Faculty Publications

A murine model system was established to study immune responses to the Pnu-Imune vaccine, which is made up of 23 different pneumococcal capsular polysaccharides. In this animal model, antibody-forming cell responses to 21 of 23 individual polysaccharides in the vaccine were detected. The Pnu-Imune vaccine elicited good antibody responses from the spleens and mesenteric lymph nodes (MLN) of young mice, whereas a variety of other peripheral lymph nodes were unresponsive. The immunoglobulin M plaque-forming cell (PFC) response in the spleen to the Pnu-Imune vaccine (given intraperitoneally or subcutaneously) decreased dramatically with increasing age. However, the spleen and MLN differed in …

Differentiation Of Renal Beta-Intercalated Cells To Alpha-Intercalated And Principal Cells In Culture., Geza Fejes-Tóth, Aniko Náray-Fejes-Tóth

Dartmouth Scholarship

The renal collecting duct is a heterogenous epithelium consisting of intercalated cells (ICC) and principal cells (PC). The origin of this cellular heterogeneity is not clear. To test the hypothesis that the two cell types might originate from one another, pure populations of ICC (beta subtype) and PC were isolated by fluorescence-activated cell sorting and grown on permeable supports. After the monolayers reached confluence, the expression of ICC- and PC-specific functions and antigens was monitored. Cultures of sorted beta-ICC, in addition to expressing ICC-specific functions (such as an electrogenic H+ secretion) and antigens, progressively acquired PC functions (amiloride-sensitive Na+ transport …

Modulation Of Rat Hepatic S9-Dependent Mutagenesis, Dna Binding, And Metabolism Of Aflatoxin B1 And Benzo[A]Pyrene By Four Chinese Medicinal Herbs, Brian Yuen Yau Wong

Loma Linda University Electronic Theses, Dissertations & Projects

Extracts of the herbs Oldenlandia diffusa (OD) and Scutellaria barbata (SB) have been used in traditional Chinese medicine for treating liver, lung and rectal tumors while extracts of Astragalus membranaceus (AM) and Ligustrum lucidum (LL) are often used as adjuncts in cancer therapy. In this study, we determined the effects of aqueous extracts of these four herbs on aflatoxin B₁ (AFB₁) benzo[a]pyrene (BaP), benzo[a]pyrene 7,8-dihydrodiol (BaP 7,8-DHD) and benzo[a]pyrene 7,8-dihydrodiol-9,10-epoxide (BPDE)-induced mutagenesis, mediated by enzymes in rat hepatic 9000 x g supernatant (S9), in Salmonella typhimurium TA100. We also studied the effects of these four herbs on …

Cortisol In The Ovine Fetus : Its Regulation And Role In Parturition, Ede Marie Apostolakis

Loma Linda University Electronic Theses, Dissertations & Projects

In fetal sheep, circulating cortisol increase during late gestation to abruptly rise 72 hours preceding birth. Although the surge in cortisol is thought to initiate the endocrine cascade which triggers parturition, it is not known what drives the prepartum rise in fetal cortisol. The first study tested the hypothesis that basal cortisol secretion is regulated by adrenocorticotropin (ACTH) which in turn, is controlled by arginine vasopressin (AVP). The fetus challenged with AVP increased plasma ACTH and cortisol concentrations. Pretreatment with an AVP V₁ receptor antagonist blocked AVP-induced plasma ACTH cortisol but failed to alter basal ACTH or cortisol. To …

Ability Of Cylindrical Root Form Implants To Withstand Controlled Lateral Forces, Silvio Emanuelli

Loma Linda University Electronic Theses, Dissertations & Projects

The ability of root form implants to withstand lateral forces has been investigated in animal model. Two new techniques for quantification of forces generated by a loading device have been developed and tested. The strain gages bonded to the loading device were calibrated either intraorally by a micro load cell, or in laboratory by Instrom Machine.

Preliminary results indicate that laterally applied continuous forces up to 6,000 grams do not elicit failure of root form implants.

New In Vivo And In Vitro Techniques For Quantification Of Lateral Force Levels That Cause Implants To Fail : A Progress Report On Monkey Research, V. Leroy Leggitt

Loma Linda University Electronic Theses, Dissertations & Projects

Two new techniques for quantification of forces generated by an expansion screw apparatus placed between pairs of cylindrical endosseous titanium implants are described, along with preliminary data gained from their use in Macaca rhesus monkeys. Strain gages were bonded to the expansion apparatus and were calibrated either directly by micro load cell, or indirectly by Instron Machine to reflect the applied force.

Immediate loads of up to 6 kilograms have been applied to the implants with no increase in mobility as verified by a Periotest device. No previous studies on the orthodontic uses of implants have evaluated in vivo forces …

Characteristics Of Habitual Dysfunctional Behaviors, Carole Ryan Serena

Loma Linda University Electronic Theses, Dissertations & Projects

The suggestion that habitual dysfunctional behavior disorders (HDBs) have a common underlying cluster of addictive characteristics and dynamics is new. A broad research base which would support this theory has not kept current with clinical In order successes. In order to address the need for relevant research, an anonymous cross sectional study was designed to identify, describe and compare variables associated with 15 habitual dysfunctional behaviors (HDBs) in a sample (N =176) from a broad spectrum of socioeconomic groups.

People reporting two different HDBs (alcohol and food-related behaviors) were compared to those not reporting any HDBs on levels of four …

The Effect Of Electrical Stimulation Of The Dorsal Raphe Nucleus On Local Cerebral Glucose Metabolism And Epileptogenesis In The Rat, Clifford C. Douglas

Loma Linda University Electronic Theses, Dissertations & Projects

Anatomic connections between the dorsal raphé and the hippocampus have been described in the literature; however, the understanding of the functional importance of these connections is not complete. In these studies the "functional" raphé-hippocampal pathway was elucidated first by the 2-deoxy-d-glucose (2-DG) method, and second by the effect of dorsal raphé electrical stimulation on kindled seizure in the rat. In the 2-DG study, differences in local rates of cerebral glucose metabolism were quantified. The pattern of 2-DG uptake differed significantly from controls (animals with electrodes placed and not receiving an electrical stimulus) and subjects stimulated in the pontine oral reticular …

Insulin Receptor And Epidermal Growth Factor Receptor Dephosphorylation By Three Major Rat Liver Protein-Tyrosine Phosphatases Expressed In A Recombinant Bacterial System, Naotake Hashimoto, Wei-Ren Zhang, Barry J. Goldstein

Department of Medicine Faculty Papers

Protein-tyrosine phosphatases (PTPases) play an essential role in the regulation of signal transduction mediated by reversible protein-tyrosine phosphorylation. In order to characterize individual rat hepatic PTPases that might have specificity for autophosphorylated receptor tyrosine kinases, we isolated cDNA segments encoding three PTPases (PTPase 1B, LAR and LRP) that are expressed in insulin-sensitive liver and skeletal muscle tissue, and evaluated their catalytic activity in vitro. The intrinsic PTPase activities of the full-length PTPase 1B protein and the cytoplasmic domains of LAR and LRP were studied by expression of recombinant cDNA constructs in the inducible bacterial vector pKK233-2 using extracts of …

Differential Regulation Of Collagenase Gene Expression By Retinoic Acid Receptors--Alpha, Beta And Gamma, Luying Pan, Stephen H. Chamberlain, David T. Auble, Constance E. Brinckerhoff

Dartmouth Scholarship

The mechanisms involved in retinoic acid (RA)-mediated regulation of the collagenase gene in a rabbit synovial fibroblast cell line (HIG82) were investigated. When HIG82 cells are cotransfected with expression vectors containing cDNAs for retinoic acid receptor (RAR) α1, β2, or γ1 and collagenase promoter-driven CAT reporter constructs, only RAR-γ1 represses basal CAT expression upon RA treatment, while RAR-α1, β2, and γ1 all suppress phorbol-induced CAT expression. Thus, transcriptional regulation of collagenase by RA is mediated by RARs in an RAR-type specific manner. Using mutatlonal and deletional analysis, we find that interaction between elements within 182 bp collagenase promoter plays an …

Plasticity Of The Gnrh Neuronal System During Sexual Maturation Of The Male Djungarian Hamster, Kevin L. Buchanan

Loma Linda University Electronic Theses, Dissertations & Projects

Onset of puberty in male Djungarian hamsters is characterized by increased pituitary gonadotropin secretion and testes maturation, and is controlled by neurons within the brain which secrete gonadotropin-releasing hormone (GnRH). Puberty is associated with increased numbers of morphologically unipolar, but not bipolar, GnRH neurons in the medial preoptic area (MPOA) and diagonal band of Broca (DBB). To test the hypothesis that delayed sexual maturation arrests this increase, males were exposed to short days or administered melatonin. Males with delayed puberty had significantly fewer unipolar GnRH neuron numbers in the MPOA and DBB comparable to pubertal controls in long days. Unipolar …

Dna Extraction From Preserved Trout Tissues, D. K. Shiozawa, J. Kudo, R. P. Evans, S. R. Woodward, R. N. Williams

Great Basin Naturalist

We have adapted techniques developed for the extraction of DNA from formalin-fixed, paraffin-imbedded human tissues for use on preserved fish tissues. DNA was successfully extracted and the d-loop region of mitochondrial DNA was amplified with the polymerase chain reaction (PCR). The sequences of the amplified DNA from preserved and modern samples were identical. These techniques were also applied to fin tissue treated with a variety of preservatives. Extraction of DNA from ethyl alcohol and air-dried fin tissues gave yields equivalent to those from frozen tissues. Extraction of DNA from preserved museum specimens of rare or extinct taxa could significantly increase …

Lying: A Failure Of Autonomy And Self-Respect, Jane Zembaty

Center for the Study of Ethics in Society Papers

Presented to the WMU Center for the Study of Ethics in Society - March 19, 1992.

Update - May 1992, Loma Linda University Center For Christian Bioethics

Update

In this issue:

[ Faith, Medicine, and Religious Liberty - Part 2, Christian Science ]
-- Spiritual Healing for Children
-- Religious Liberty, Spiritual Healing, and the Health Care of Children
-- Spiritual Healing, Laws, and Constitutional Free Exercise of Religious Rights
-- Baby Theresa: Parental Choice Must Reign in the Case of Brain-Absent Newborns
-- Anencephalic Infants as Organ Donors: Do We Follow Rules or Emotions?

Transformation Of A Continuous Rat Embryo Fibroblast Cell Line Requires Three Separate Domains Of Simian Virus 40 Large T Antigen., Jiyue Zhu, Philip W. Rice, Lisa Gorsch, Marina Abate, Charles N. Cole

Dartmouth Scholarship

Mouse C3H 10T1/2 cells and the established rat embryo fibroblast cell line REF-52 are two cell lines widely used in studies of viral transformation. Studies have shown that transformation of 10T1/2 cells requires only the amino-terminal 121 amino acids of simian virus 40 (SV40) large T antigen, while transformation of REF-52 cells requires considerably more of large T antigen, extending from near the N terminus to beyond residue 600. The ability of a large set of linker insertion, small deletion, and point mutants of SV40 T antigen to transform these two cell lines and to bind p105Rb was determined. Transformation …

Cytolytic T Lymphocytes Specific For Tumors And Infected Cells From Mice With A Retrovirus-Induced Immunodeficiency Syndrome., Jennifer G. Erbe, Kathy A. Green, Karen M. Crassi, Herbert C. Morse, W R. Green

Dartmouth Scholarship

LP-BM5 retrovirus complex-infected C57BL/6 mice develop immunodeficiency, somewhat analogous to AIDS, termed murine AIDS (MAIDS). After secondary stimulation with syngeneic B-cell lymphomas from LP-BM5-infected mice, C57BL/6 mice produced vigorous CD8+ cytotoxic T lymphocytes specific for MAIDS-associated tumors. An anti-LP-BM5 specificity was suggested because spleen and lymph node cells from LP-BM5-infected mice served as target cells in competition assays, and cells from LP-BM5, but not ecotropic, virus-infected mice functioned as secondary in vitro stimulators to generate cytotoxic T lymphocytes to MAIDS tumors.

Molecular And Cellular Analysis Of Chlamydia Trachomatis: Persistence And Reactivation, Kimberly R. Tau

Electronic Theses and Dissertations

Chlamydia trachomatis (CT) is the most prevalent sexually-transmitted infection in the United States. It has been suggested that CT infections can become latent. This has not been substantiated. CT persistence was examined at the molecular and cellular level in vitro and in vivo. Penicillin treatment of CT in vitro results in abnormal inclusions and reduced recovery of infectious CT. Penicillin did not inhibit initial stages of infection, but did downregulate CT rRNA levels after 25 hours post-inoculation (p.i.). DNA amplification was employed to differentiate between a resolved infection and a persistent one. Utilizing a primer pair that amplified a 144 …

Occupational Stress Among Nurse Administrators In General Hospitals In Tennessee, Ruby T. Davis

Electronic Theses and Dissertations

The purpose of this study was to determine the level of occupational stress among nurse administrators and to identify the types of strategies used by nurse administrators to deal with or manage occupational stress. The study examined the relationship between selected demographic variables, occupational stress, and strategies. The research design included five research questions along with seven null hypotheses testing the relationship between occupational stress and demographic variables--age, gender, marital status, years of professional nursing experience, years as a nurse administrator, educational attainment, and hospital bed capacity. There were seven additional hypotheses testing the relationship between the same demographic variables …

The Proposed Use Of An Anatomically Marked Presurgically Fitted Prostheses With Infants Who Have Unrepaired Cleft Palates, Amy Moser

Undergraduate Honors Capstone Projects

Approximately one out of every 750 children are born with some type of an oral cleft (McWilliams, Morris, & Shelton, 1984) Children with clefts of the palate in general have a higher incidence of articulation disorders than do children without clefts. Typical speech problems which tend to occur are hypernasality and multiple articulation errors, often consisting of atypical tongue placement in the mouth or nontypical articulation at sites in the larynx or pharynx. These speech problems can be severe and may require years of expensive, long-term professional treatment to remediate.

Immunological Effects Of Amphotericin B Desoxycholate And Liposomal Amphotericin B On Splenocytes From Immune-Normal And Immune-Compromised Mice, Jay Jenson Schindler

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Because of the increasing number of serious risk factors which predispose a normally immune competent host to infection, the incidence of systemic fungal infections is steadily increasing. This epidemiological rise has especially become apparent since the onset of the AIDS epidemic. Amphotericin B is the drug of choice for these life-threatening mycotic infections. Complications due to drug toxicity, however, severely limit amphotericin B's clinical usefulness. The major complication associated with the administration of amphotericin B is renal toxicity. Research has indicated, however, that besides its antifungal activities, amphotericin B may act as an immune stimulant of both humoral and cellular …

An Assessment Of Food Sanitation Knowledge And Practice Of Restaurant Workers In Taichung City, Taiwan, Shiow-Fu Sheu

Community & Environmental Health Theses & Dissertations

Taichung city is located in the western middle part of Taiwan, with a population of nearly 800,000. The total number of food service establishments in Taichung City is more than 10,000. Among these, nearly 2000 of the food establishments are considered restaurants. For such a large number of restaurants, the total number of food sanitation inspectors is 16. In order to overcome the shortage of the food inspector manpower problem, Taichung City Health Department has set up a "Food Sanitation Self-inspection Program", in an effort to encourage the restaurants to direct more attention to food sanitation problems. In the meantime, …

Regulation Of Melanogenesis At The Sub-Cellular Level In Cloudman Murine Melanoma Cells, Kenneth Rosenzweig

Yale Medicine Thesis Digital Library

The decarboxylation of dopachrome to 5,6-dihydroxyindole (DHI) appears to be a major control point in the biosynthesis of melanin, in particular the conversation of dopachrome to 5,6-dihydroxyindole-2-carboxylic acid (DHICA). The recent discovery of a factor, DHICA stablin, that stabilizes DHICA and inhibits its conversion to DHI has added insight into the regulation of this intermediary compound. This study has shown that DHICA stablin activity is present in the melanosomal fraction of Cloudman murine melanoma cells and that this activity was observed by a new method using two complementary decarboxylase assays. When three known decarboxylase stabilizing cofactors (biotin, pyridoxal phosphate, and …

Hypothalamic Excitatory Amino Acid Receptors Mediate Stress-Induced Tachycardia In Rats, Robert P. Soltis, Joseph A. Dimicco

Scholarship and Professional Work – COPHS

The role of hypothalamic excitatory amino acid (EAA) receptors in mediating the cardiovascular response to stress was examined using conscious chronically instrumented rats. Microinjection of the EAA agonists N-methyl-D-aspartic acid (NMDA; 1-10 pmol), alpha-amino-3-hydroxy-5-methyl-4-isooxazolepropionic acid (AMPA; 0.3-3.0 pmol), or kainic acid (0.1-1.0 pmol) into the dorsomedial hypothalamus (DMH) elicited dose-related increases in heart rate and modest elevations in arterial pressure. Local microinjection of the NMDA antagonist 2-amino-5-phosphonopentanoic acid (AP5; 100 pmol) selectively blocked NMDA-induced cardiovascular changes, whereas the non-NMDA EAA antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX; 50 pmol) selectively blocked the responses to AMPA and kainic acid. In the stress trials, microinjection of …