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Physical And Chemical Stability Of Spray Dried Sugars And Protein-Sugar Molecuiar Mixtures For Inhalation, Venkatesh Naini

Theses and Dissertations

The feasibility of producing inhalable microparticles of sugars and protein-sugar molecular mixtures using spray drying was investigated as an alternative to conventional micronization techniques. Four sugars; lactose (L), trehalose (T), sucrose (S) and mannitol (M) were spray dried using a commercial bench-top spray dryer and their physicochemical stability, with respect to particle size, moisture uptake and crystallinity changes, investigated after storage at 23%, 52%, 75% and 93% relative humidity (RH) and 25 °C for 30 days. Two crystalline size fractions (“coarse” = 125-212 μm and “fine” = 44-74 μm) of each sugar, were also characterized, as possible replacements for lactose …

An Epidemiologic Investigation Of The Possible Association Between Maternal Diabetes And Maternal Hypertension And Placental Infection With Ureaplasma Urealyticum., Richard Joseph Sinsky

All ETDs from UAB

No abstract provided.

Effect Of Neurotrophic Factors On Cholinergic Neurons In The Septo-Hippocampal Pathway Of Normal And Af64a Treated Rats, Christopher Andrew Willson

Dissertations

No abstract provided.

The Effect Of Estrogen In A Murine Model Of Peritoneal Adhesion Formation, Michelle Rene Frazier-Jessen

Dissertations

No abstract provided.

A Dialogue Between Banyankole-Bakiga Peoples' Traditional Pre- And Marital Counseling Since 1870s And The Western Cognitive Behavior And Object Relations Therapies: A Reciprocal Challenge And Insight?, Cecilia Y. Nibyobyonka

Master's Theses

No abstract provided.

Use Of Alternative Approaches By Physical Therapists In Michigan, Karen E. Huber, Brian W. Scherff

Masters Theses

The purpose of this research was to determine the prevalence of use of alternative treatments by physical therapists in Michigan, what approaches are used most often and if use of alternative techniques is associated with practice characteristics. A questionnaire listing 20 treatment techniques which met the operational definition of alternative was mailed to a random sample of 300 licensed physical therapists in Michigan. Number of modalities used, frequency of use for each alternative treatment, average caseload treated, and relationships between modality use and characteristic of practitioners were determined. Results showed 83% of respondents use one or more alternative modalities; 39% …

Comparison Of The Effects Of Aerobic Dance To Water Aerobic Training On Maximal Oxygen Consumption, Terri L. Bedford, Tamara A. Dusterwinkle, Darcy J. Hoppman

Masters Theses

Water aerobics is one mode of exercise that is gaining popularity. Water aerobics allows adults who participate in an exercise program to improve their cardiorespiratory fitness. The purpose of this study was to determine if water aerobic training is as effective as land dance aerobic training in improving cardiorespiratory fitness in sedentary healthy adults. Eighteen subjects participated in this study; nine in dance aerobics and nine in water aerobics. Before and after eight weeks of training, subjects performed a graded maximal exercise test on a Schwinn Air-Dyne while maximal oxygen uptake was measured via a Beckman Metabolic Cart. ANCOVA was …

A Comparison Study Of Emergency And Medical/Surgical Registered Nurses' Understanding Of Pain And Its Management, Jo A. Oborski

Masters Theses

This replication study was designed to compare emergency and medical/surgical registered nurses' actual and perceived knowledge of the pharmacological and nonpharmacological aspects of pain and its management. A modification of the original tool that consisted of a combination of multiple choice, short answer and open-ended questions was utilized. A convenience sample representing beginner and expert medical/surgical and emergency nurses was obtained.; No difference was found between specialty or experience and current pain knowledge. All participants functioned at a similar level. Participants were unable to describe basic terms related to current pain theory and therapy. The only significant difference identified between …

Pre- And Post-Operative Comparison Of Kinematic Data In Ambulatory Patients With Cerebral Palsy, Douglas A. Miller, Matthew J. Vanderkooi

Masters Theses

Computerized three-dimensional gait analysis effectively supplements clinical examination by objectively assessing dynamic gait abnormalities and surgical outcomes. The purpose of this research was to assess the ambulatory outcomes of corrective surgery performed on children with spastic cerebral palsy by comparing pre- and post-operative kinematic data. It was hypothesized that post-operative data would be significantly improved compared to pre-operative values. Clinical examination and computerized gait analysis were performed pre-operatively and six to eighteen months following corrective surgery. Gait analysis included video taping of gait and recording of three-dimensional joint motion, synchronized force plate, and dynamic EMG data. The three patients (average …

Law And Ignorance: Genetic Therapy And The Legal Process, Roger B. Dworkin

Articles by Maurer Faculty

No abstract provided.

Cytokines In Pigs Bred Selectively For High And Low Immune Response [Abstract Only], Jay Reddy, Bruce N. Wilkie, Bonnie A. Mallard, Soren Rosendal

Jay Reddy Publications

Yorkshire pigs have been bred for high (H) and low (L) immune response based on selection for multiple antibody (Ab) and cell mediated immune response traits. High responders have better production and larger litter size when compared with controls and low responders. The ability of high and low line pigs to resist M. hyorhinis infection has been tested. The high responders had more rapid and higher Ab response and the severity of the disease was less, as judged by clinical and postmortem signs. However, arthritis was found to be relatively more severe in high responders. We hypothesized that the immune …

All Our Days Are Numbered --: Journey Through Breast Cancer With Traditional And Alternative Medicine, Tomma Lou Maas

Dissertations and Theses @ UNI

All Our Days Are Numbered--Joumey Through Breast Cancer with Traditional and Alternative Medicine brings hope to women who must face breast cancer. In four books, Lorna Jordan shares the events leading up to her disease; her traditional breast cancer experience; her search for alternative medicine which will improve her health; and her journey into good health. Book One, "In the Beginning," presents evidence of Lorna's developing ill health. Beginning in adolescence, Lorna's exposure to mercury, antibiotics, and DDT contribute to her poor health. Later, in early adulthood, she begins to have mood shifts and menstrual disorders. When she takes birth-control …

Influence Of Physical Fitness On Susceptibility To Noise-Induced Temporary Threshold Shift In Females, Stacy Claire Bukatz

Dissertations and Theses @ UNI

This study investigated the influence of physical fitness on susceptibility to noise-induced temporary hearing loss in 33 females of various fitness levels, and the relationship between temporary threshold shift (TTS) and distortion product otoacoustic emission (DPOAE) measurements. Behavioral audiometric thresholds and DPOAE measurements were obtained at 2000, 3000, 4000, and 6000 Hz prior to and immediately after 10 minutes of exposure to 108-dB SPL narrow-band noise centered at 2000 Hz. The greatest TTS and largest reduction in DPOAE amplitude occurred at·3000 Hz. However, no significant correlation was observed between TTS and DPOAE at any frequency or between any of the …

Exercise And Immune Function In Athletes Over Age 50, Lynda L. Graham

Dissertations and Theses @ UNI

The purpose of this study was to search for relationships between lifestyle factors and the number of upper respiratory tract infections (URTI) suffered per year in older runners. A cover letter and questionnaire were mailed to 1400 members of the Combelt Running Club. It questioned subjects about life-style factors like: (a) education, (b) occupation, (c) race, (d) activity, (e) cold episodes, (f) vitamin/mineral supplements, (g) stress, (h) diet, (i) smoking, (j) alcohol, (k) weight, (1) height, (m) caffeine, and (n) self-remedy for a cold. One hundred and thirty subjects aged 50 years of age and older participated in this study. …

Numerical Chromosome Abnormalities In Sperm From Oligoasthenoteratozoospermic Patients And Fertile Males, Myung-Geol Pang

Theses and Dissertations in Biomedical Sciences

Artificial fertilization protocols have been developed which bypass natural barriers for reproduction. One aspect of infertility which has received little attention is the potential importance of aneuploidy in sperm. To more clearly understand the cytogenetic make-up of sperm from OAT patients, multi-probe, multi-color FISH was performed to determine aneuploidy.

The introduction of intracytoplasmic sperm injection (ICSI) has revolutionized protocols used in in vitro fertilization centers. The pregnancies resulting from ICSI suggest an increased frequency of sex chromosome aneuploidy in livebirths. Preliminary data by others' suggest that sperm tail swelling patterns following hypo-osmotic swelling (HOST) can be predictive of fertilizing ability. …

One-Trial Context Fear Conditioning As A Function Of The Interstimulus Interval, Rick A. Bevins, John J. B. Ayres

Department of Psychology: Faculty Publications

In two experiments, we examined the effects of a wide range of interstimulus intervals (2.5, 15, 45, 120, 135, and 405 sec) on one-trial context fear conditioning with rats. Here, the interstimulus interval (ISI) denotes the time between placement in a conditioning chamber and the onset of a single footshock. On the conditioning day, we observed that the rats’ behavior at the time of shock onset varied systematically across ISI values. On the subsequent test day, we used context-evoked freezing as a measure of context conditioning and found the well-known inverted U-shaped ISI function. We also found that conditioned freezing …

What's Happening: December 13, 1995, Maine Medical Center

What's Happening

No abstract provided.

The Impact Of Humor On Energy, Tension, Task Choices, And Attributions: Exploring Hypotheses From Toughness Theory, Richard A. Dienstbier

Department of Psychology: Faculty Publications

Hypotheses derived from toughness theory suggest that nonaggressive humor should lead to increased feelings of energy without influencing tension, to preferences for studying materials that require more effort and energy, and to ratings of mundane laboratory activities as more challenging but not more threatening. Eighty-one college-age men and women were randomly assigned to watch a 12-minute video of Bill Cosby's humor or to watch a nonhumorous control video that analyzed the Cosby comedy routine. The humor condition resulted in significant increases in feelings of energy but not in feelings of tension. The other hypotheses were also confirmed except that performance …

2,4-Disulfonyl Phenyl Butyl Nitrone, Its Salt And Their Use As Pharmaceuticals, John M. Carney

Pharmacology and Nutritional Sciences Faculty Patents

2,4-disulfonyl α-phenyl-tert-butyl nitrone and its pharmaceutically acceptable salts are disclosed. These materials are useful as pharmaceutical agents for oral or parenteral, e.g. intravenous administration to patients suffering from acute central nervous system oxidation as occurs in a stroke or from gradual central nervous system oxidation which can exhibit itself as progressive central nervous system function loss. The materials are also used to ameliorate the side effects of oxidative-damage causing antineoplastic disease treatments.

Phenyl Butyl Nitrone Compositions And Methods For Treatment Of Oxidative Tissue Damage, John M. Carney, Robert A. Floyd

Pharmacology and Nutritional Sciences Faculty Patents

Compositions for treating tissue damage from ischemia contain PBN, or active derivatives thereof, which are active during ischemia in preventing ATP depletion of the cells which predisposes them to subsequent injury during reperfusion, and which are active during reperfusion as oxygen radical scavengers, in a suitable pharmaceutical carrier for systemic or local administration, especially to the CNS, spinal column and eyes. Based on animal studies, the dosage for treating damage due to stroke is in the range of 10 to 300 mg/kg. Similar dosages are useful in treating damage resulting from free radical generation during inflammation, either as a product …

Ua66/14/4 Kentucky Partnership Newsletter, Vol. Ii, No. 9, Kentucky Partnership For Farm Family Health & Safety

University Organizations

Newsletter created by and about the Kentucky Partnership for Farm Family Health & Safety.

Jefferson Alumni Bulletin – Volume Xlv, Number 1, December 1995

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLV, Number 1, December 1995

We will fight cancer with molecular therapeutics and prediagnostics, page 4

Behavior and economics will challenge prevention, page 6

From genetic understanding to cure, page 9

Computer-based teaching reshapes how students learn, page 12

Will tomorrow’s journals be electronic? Page 14

Jefferson health system upgrades its information technology, page 17

Molecule essential for cell growth and division is discovered at Jeff, page 19

Current Theories On The Cell Biology Associated With Tooth Movement, Mohamadreza Yazdi

Loma Linda University Electronic Theses, Dissertations & Projects

This article discusses the current information on the mechanism of the biological signaling that takes place to bring about orthodontic tooth movement.

Currently, there are two general theories as to how orthodontic mechanical force is translated to biologically meaningful signals for the cells of the periodontium. These include a cellular-humoral response and a bioelectric response.

There are various mechanisms utilized by the cells of the periodontium to bring about the cellular-humoral response. These include: The activation of the cells of the immune system to synthesize and release specific chemicals (cytokines) which affect cell function, direct effects of mechanical force on …

Repellence Of The Tick Rhipicephalus Appendiculatus By The Grass Melinis Minutiflora, Esther N. Mwangi, S. Essuman, G. P. Kaaya, E. Nyandat, D. Munyinyi, M. G. Kimondo

All Peer-Reviewed Publications

In a study to develop anti-tick pastures, the climbing behaviour of Rhipicephalus appendiculatus on Melinis minutiflora (molasses grass) was investigated. Experiments were done with cut green stems of grass, grass dried in the shade, grass dried in sunshine, grass washed in solvent and grass growing in a study plot. In all cases a common pasture grass, Pennisetum clandestinum (Kikuyu grass), was used as control. All instars of the tick avoided climbing on the green M. minutiflora whereas most larvae, nymphs and adults climbed on the control green P. clandestinum grass. More ticks climbed on the stems dried in the sunshine …

Ovum Pick Up In Thai Native Calf(Ovum Pick Up ในลูกโคพื้นเมืองไทย), Chainarong Lohachit, Mongkol Techakumphu, Wichai Tantasuparak, Kaywalee Chatdarong, Siriwat Suadsong

The Thai Journal of Veterinary Medicine

The oocyte collection by using Real time B-mode scanning ultrasound (Ovum Pick Up) was performed in four Thai native calves aged 5-6 mts, weight 100 kg. All calves had an ear norgotromet progestagen implant for 7 days before ovarian stimulation. The calves were stimulated by follicle stimulting hormone (FSH) at dose of 120 mg, IM twice a day (am/pm) for 3 days as follow: 30/30, 20/20, 10/10 mg. The oocytes were collected 24 hrs. after the last injection of FSH. Every calf had a repeat stimulation every two weeks for one to five times. The average oocytes per collection was …

A Requirement For Bone Morphogenetic Protein-7 During Development Of The Mammalian Kidney And Eye., Andrew T. Dudley, K. M. Lyons, E. J. Robertson

Journal Articles: Genetics, Cell Biology & Anatomy

BMP-7/OP-1, a member of the transforming growth factor-beta (TGF-beta) family of secreted growth factors, is expressed during mouse embryogenesis in a pattern suggesting potential roles in a variety of inductive tissue interactions. The present study demonstrates that mice lacking BMP-7 display severe defects confined to the developing kidney and eye. Surprisingly, the early inductive tissue interactions responsible for establishing both organs appear largely unaffected. However, the absence of BMP-7 disrupts the subsequent cellular interactions required for their continued growth and development. Consequently, homozygous mutant animals exhibit renal dysplasia and anophthalmia at birth. Overall, these findings identify BMP-7 as an essential …

Host Restriction Phenotypes Of Salmonella Typhi And Salmonella Gallinarum, Lisa Pascopella, Bärbel Raupach, Nafisa Ghori, Denise Monack, Stanley Falkow, P. L. C. Small

Public and Community Health Sciences Faculty Publications

Salmonella typhi and Salmonella gallinarum phenotypes correlated with mouse host restriction have been identified by using in vitro and in vivo systems. S. typhi is capable of entering the murine intestinal epithelium via M cells, as is Salmonella typhimurium, which causes systemic infection in the mouse. But, unlike S. typhimurium, S. typhi does not destroy the epithelium and is cleared from the Peyer’s patches soon after M-cell entry. S. gallinarum appears to be incapable of entering the murine Peyer’s patch epithelium. Our in vitro evidence suggests that S. gallinarum is taken up in murine phagocytic cells by a mechanism different …

Dentalgram - Vol. 09, No. 11, Loma Linda University School Of Dentistry

Dentalgram

In this issue:

• New student assistant
• Family Clinic Protocol
• Teacher at AADS
• Alumni in Vegas
• New textbook
• Student tour
• New insurance location
• Mission opportunities
• Retreat pictures
• Staff helping kids
• New lounge look
• School downsizing
• Epic tournament

Is The Teaching Of Humanae Vitae Physicalist? A Critique Of The View Of Joseph A. Selling, Mark S. Latkovic

The Linacre Quarterly

No abstract provided.

Stimulation Of Alpha 1(I) Procollagen Gene Expression In Nih-3t3 Cells By The Human T Cell Leukemia Virus Type 1 (Htlv-1) Tax Gene., E. Munoz, D. Suri, S. Amini, K. Khalili, Sergio A. Jimenez

Selected Works of Sergio Jiménez, MD, MACR

The mechanisms that regulate the expression of genes encoding extracellular matrix proteins in fibroblasts and other mesenchymal cells have remained elusive. Studies from several laboratories have indicated that Tax, a trans-regulatory protein from the human T cell leukemia virus type I not only augments viral gene expression but also triggers the expression of various cellular genes. Here, we examined the hypothesis that the expression of collagen genes may also be modulated by Tax. NIH-3T3 cells were simultaneously transfected with a Tax expressor plasmid and a chimeric construct containing regulatory sequences (-804 to +42 bp) of the alpha 1(I) procollagen gene …