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Clinical And Neuropathological Characteristics Of The New Variant Of Cdj And Other Human And Animal Transmissible Spongiform, T. Hemachudha

Chulalongkorn Medical Journal

No abstract provided.

Lead Activation Of A Developmentally Regulated Calcium Channel In Rat Hippocampal Nerve Terminals, Troy E. Rhodes

Theses and Dissertations in Biomedical Sciences

Low level lead (Pb²⁺) exposure may produce lasting deficits in learning and memory by altering calcium (Ca²⁺) dependent processes. Isolated presynaptic nerve terminals from rat hippocampus were loaded with the intracellular (Ca²⁺) indicator Fura-2. The changes in cytoplasmic free calcium ([Ca²⁺]_i) were measured by stopped-flow fluorescence spectroscopy following depolarization with elevated potassium on a millisecond time scale (Lentzner et al., 1992). Depolarization promoted a rapid increase in Ca²⁺_i which occured in two kinetically distinguishable phases: a fast component, representing the activity of rapidly inactivating Ca²⁺ channels (τ …

Differential Expression Of The Toxr Regulon In Classical And E1 Tor Biotypes Of Vibrio Cholerae Is Due To Biotype-Specific Control Over Toxt Expression., Victor J. Dirita, Melody Neely, Ronald K. Taylor, Paul M. Bruss

Dartmouth Scholarship

The two major disease-causing biotypes of Vibrio cholerae, classical and El Tor, exhibit differences in their epidemic nature. Their behavior in the laboratory also differs in that El Tor strains produce two major virulence factors, cholera toxin (CT) and the toxin coregulated pilus (TCP), only under very restricted growth conditions, whereas classical strains do so in standard laboratory medium. Expression of toxin and TCP is controlled by two activator proteins, ToxR and ToxT, that operate in cascade fashion with ToxR controlling the synthesis of ToxT. Both biotypes express equivalent levels of ToxR, but only classical strains appear to express ToxT …

Neuronal Toxicity Of Humoral Factors From Patients With Diabetic Neuropathy And Mechanism Of Neuronal Death On Cultured Adrenergic Neurons: Studies Of Autoimmune Pathogenesis In Diabetic Neuropathy, Dong Liu

Theses and Dissertations in Biomedical Sciences

Diabetic neuropathy is an extremely common medical problem because of the high frequency of diabetes and its complications. Diabetic neuropathy consists of not one, but many patterns of nerve injury, each potentially with its own discrete pathogenic mechanisms. Evidence is accumulating that indicates autoimmunity plays a role in diabetic peripheral neuropathy. However, the significance of immunopathogenesis of diabetic neuropathy is as yet unclear.

Using the N1E-115 mouse neuroblastoma cell line (NB) as a model of the adrenergic autonomic neuron, we found that sera of IDDM patients with neuropathy inhibit growth and differentiation of adrenergic neurons in culture (Pittenger et al, …

Second-Order Conditioning Detects Unexpressed Morphine-Induced Salt Aversion, Rick A. Bevins, Timothy A. Delzer, Michael T. Bardo

Department of Psychology: Faculty Publications

Morphine failed to condition a salt taste aversion at a dose (15 mg/kg) sufficient to produce a robust aversion to a saccharin taste. Indeed, three different concentrations of salt (1%, 1.5%, and 2%) paired with the same morphine dose yielded no direct evidence for conditioned aversion. Yet, when a novel saccharin taste was paired in compound with the previously conditioned salt conditioned stimulus, we found evidence for a conditioning to the saccharin cue alone in three separate experiments. Control groups eliminated alternative accounts such as neophobia and differential exposure to morphine. Combined, these findings indicate that morphine conditioned a salt …

In The Affirmative, Vol.3, No.3 (Mid-June/Mid-July 1996), Mike Martin, The Aids Project

In the affirmative (1993-1999)

No abstract provided.

What's Happening: June 12, 1996, Maine Medical Center

What's Happening

No abstract provided.

Genome Research And Traditional Intellectual Property Protection -- A Bad Fit?, Kate H. Murashige

RISK: Health, Safety & Environment (1990-2002)

Dr. Murashige addresses the need for a patent system more closely tailored to the needs of biotechnology. For example, the obviousness requirement may interfere with using patents to recoup high costs of work when it could arguably be done by researchers of ordinary skill.

Impact Of The Human Genome Project At The Interface Between Patent And Fda Laws, Brian C. Cunningham

RISK: Health, Safety & Environment (1990-2002)

Mr. Cunningham stresses the broad scope of biotechnological innovations. Besides endorsing the need for a new oversight commission to deal with potential social issues, he suggests, for example, that some products should be treated like biologics rather than new drugs.

Development Of Vaccines To Meet Public Health Needs: Incentives And Obstacles, Phillip K. Russell

RISK: Health, Safety & Environment (1990-2002)

Dr. Russell explains how such matters as high 'costs of regulation, lack of an effective plan for delivery (particularly abroad) and politics can interfere with providing globally needed vaccines.

Periodontal Repair In Dogs : Effect Of Recombinant Human Transforming Growth Factor Beta-1 On Guided Tissue Regeneration, Saghi Shayan Razi

Loma Linda University Electronic Theses, Dissertations & Projects

The objective of this study was to evaluate bone and cementum regeneration in the critical size, supraalveolar, periodontal defect model following surgical implantation of recombinant human transforming growth factor beta-1 (rhTGFß-1) in conjunction with guided tissue regeneration (GTR). Five male beagle dogs were used in a split-mouth design. Alternate jaw quadrants in consecutive animals received GTR with rhTGFß-1 in a resorbable calcium carbonate carrier. Contralateral jaw quadrants received GTR with carrier only (control). The healing interval was 4 weeks. Clinical healing was generally uneventful, however, minor membrane exposures were observed for both treatments with limited gingival inflammation. All defects with …

The Effect Of Guidor™ And Hop-1 On Hard Tissue Healing : Following Periradicular Surgery In Cats, Hugh Maguire

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to evaluate the effects of the resorbable membrane Guidor™ and the osteogenic protein hOP-1 on hard tissue healing following periradicular surgery in cats.

Surgical endodontic therapy was performed on the maxillary canine teeth of twelve cats. After orthograde root canal therapy, flap reflection, osteotomy, resection of the root end, root end cavity preparation and the placement of a root end filling, eight of the surgical sites were treated with Guidor™ and eight with hOP-1. The remaining eight sites received no further treatment and served as controls.

The animals were sacrificed at twelve weeks following …

The Effects Of Lowering Cholesterol On Vasodilation, Maria Christi Hardt

Loma Linda University Electronic Theses, Dissertations & Projects

Endothelial dysfunction has been found prior to any signs of atherosclerotic plaque formation in patients with a variety of risk factors for atherosclerosis. Elevated serum cholesterol has repeatedly been associated with endothelial dysfunction as demonstrated by impaired vasoreactivity to vasodilating stimuli.

The aim of this research was to determine whether short term lowering of serum cholesterol levels by life style changes or by cholesterol lowering medication could reverse or reduce the endothelial dysfunction. The brachial artery diameter was measured by high-resolution ultrasound at rest and during reactive hyperemia pre and postintervention. Fifty-three subjects with cholesterol levels above 240 mg/dl were …

Speak Of The Devil: Rhetoric In Claims-Making About The Satanic Ritual Abuse Problem, Mary Deyoung

The Journal of Sociology & Social Welfare

This paper uses Toulmin's (1958) scheme to conduct a rhetorical analysis of claims being made in the construction of the satanic ritual abuse of children problem. The analysis reveals that the persistence of these claims over the last fifteen years is the product not of their compelling facts or their effective conclusions, but of their persuasive warrants. These implicit, "self-evident truths" resonate well with recent cultural concerns about the vulnerability of children to abuse, and the satanic menace.

The Latency-Related Gene Of Bovine Herpesvirus 1 Encodes A Product Which Inhibits Cell Cycle Progression, L. M. Schang, Ashfaque Hossain, Clinton J. Jones

School of Veterinary and Biomedical Sciences: Faculty Publications

Bovine herpesvirus 1 (BHV-1) establishes a latent infection in the sensory ganglionic neurons of cattle. The exclusive viral RNA expressed in a latent infection is the latency-related (LR) RNA, suggesting that it regulates some aspect of a latent infection. During the course of a productive infection, alphaherpesviruses induce certain events which occur during cell cycle progression. Consequently, we hypothesized that a BHV-1 infection might induce events in neurons which occur during cell cycle progression. In agreement with this hypothesis, cyclin A was detected in neurons of trigeminal ganglia when rabbits were infected. Neuronal cell cycle progression or inappropriate expression of …

Bone Morphogenetic Proteins And Periodontal Repair, Michael B. Lee

Loma Linda University Electronic Theses, Dissertations & Projects

For over thirty years now, research has been carried out to isolate and purify bone morphogenetic protein (BMP), a substance which has been shown to induce heterotopic bone formation in various animal species. Recent advances in the fields of developmental biology, molecular biology and genetics, have shown that the BMPs not only are responsible for postfetal bone induction (including normal bone remodeling, healing and repair), but are also critical during embryogenesis - not only in regards to the skeletal system, but quite possibly in the morphogenesis and pattern formation of other tissues and organs as well.

Due to their bone …

The Anthelmintic Effects Of Bithionol Sulfoxide Against Sheep Experimentally Infected With Fasciola Gigantica(ประสิทธิผลของยาถ่ายพยาธิใบไธโอนัล ซัลฟอกไซด์ต่อพยาธิใบไม้ตับในแกะทดลอง), Tasanee Chompoochan, Piyanoot Prasitirat, Suree Thammasart, Suwannee Nithiuthai, Noriyuki Taira

The Thai Journal of Veterinary Medicine

The treatment of Fasciola gigantica infection with Bithionol sulfoxide was investigated in sheep that had been experimentally infected with 500 metacercariae. Ten sheep were divided into 3 groups: group 1 (n=4) were given a single dose of Bithionol sulfoxide 80 mg/kg orally at week 22 after infection, group 2 (n=4) were untreated positive controls and group 3 (n=3) were untreated negative controls. All animals were examined for Fasciola eggs per gram (epg) in faeces for the beads technique at weekly interval for a period of 28 weeks. The egg during weeks 22-23 were examined daily. The results revealed that on …

Concurrent Studies Of Plasma And Serum Cholinesterase Activity In Six Species Of Domestic Animals(การทำงานของเอนไซม์โฆลีนเอสเทอเรสในพลาสม่า และซีรั่มของสัตว์ 6 ชนิด), Wara Panichkriangkrai, Piyarat Subhachalat

The Thai Journal of Veterinary Medicine

Serum and plasma cholinesterase in normal animals were determined concurrently to see whether both values can be used interchangeably. Plasma, with EDTA as an anticoagulant and serum of horses, donkeys, mules, cattle, buffaloes and sheep were collected and cholinesterase activity was determined by colorimetric method. Results showed that plasma cholinesterase activity in all species except cattle was significantly lower than the activity in serum. Since organophosphorus compounds have cholinesterase inhibition property, the use of inhibited plasma cholinesterase as an indicator for organophosphorus poison is questionable and the use of serum cholinesterase activity is recommended.(วิเคราะห์การทำงานของเอนไซม์โซลีนเอสเทอเรสในพลาสม่าและซีรั่มของสัตว์ปกติเปรียบเทียบในสัตว์ตัวเดียวกันเพื่อศึกษาว่าค่าทั้งสองนี้สามารถใช้แทนกันได้หรือไม่ ทำการเจาะเลือดจากสัตว์ 6 ชนิด ได้แก่ ม้า ลา …

1996 - The First Annual Symposium Of Student Scholars

Symposium of Student Scholars Program Books

The full program book from the First Annual Symposium of Student Scholars, held on May 10th, 1996. Includes abstracts from presentations.

The Effect Of Acute Low Ph On Feeding And Locomotor Activity Of Larval Fathead Minnows, Pimephales Promelas, Sharon Ore

Masters Theses & Specialist Projects

Lowered pH conditions in aquatic environments can have a negative impact on many aquatic organisms. In fish it has been shown that acidic water conditions may result in altered gill morphology, reduced reproductive success, changes in locomotor and feeding behavior and even death. Juveniles and adults have been the primary focus of research. However, the larval stage is potentially the most sensitive to toxicity. It is also important ontogenetically as several crucial development thresholds, such as first feeding, occur during this period. The impact of acute low pH on feeding performance was investigated in larval fathead minnows one to fifteen …

The Effect Of A Nutrition And Fitness Program On The Dietary Habits, Fitness Level, And Health Status Of Ute Indian Youth, Alison K. Lemon

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Lifestyle changes from traditional diet and activities to modem diets high in fat and sugar, and sedentary habits have increased inherited health risk for diabetes and obesity among Native American youth. Nutrition education and physical activity programs have been recommended to help reduce health-risk factors. This study evaluated a summer nutrition education and fitness program for effectiveness in improving the dietary habits, nutrition knowledge, fitness level, and health status of American Indian children ages 9-14 living on or near the Uintah-Ouray Reservation in Uintah and Duchesne Counties of Eastern Utah.

A 6-week nutrition and fitness program was conducted through the …

Ms211: Marnies, Armin Weinberg

Works on Radiation Effects: 1990-2020

This is a version of a paper on Chernobyl written by Marnie Rose a Russian Studies student who went to Bellaire High School, then UT (I think phase2) that Armin helped get her to study and visit Ukraine. Marnie unfortunately died of a glioblastoma when a Pediatric Resident at UT Houston. A fun run Run for the Rose is held in Houston each year in her memory. http://www.drmarnierose.org/. See more at Armin Weinberg, PhD Papers and its finding aid.

A Thracian Charm And Socratic Teaching: The Politics Of Education, Arlene W. Saxonhouse

Center for the Study of Ethics in Society Papers

Presented to the WMU Center for the Study of Ethics in Society, May, 1996. Dr. Saxonhouse's lecture was sponsored by the Institute for the Study of Politics and Government and was part of the Sam Clark Lectures. We extend our appreciation to the Institute and its director, James Butterfield.

Nursing Faculty Connecting With Students: A Heideggerian Hermenteutical Study, Debra I. Craig Dnsc, Msn, Rn

Dissertations

This study sought to gain an insight into the phenomenon of nursing faculty members connecting with students. Caring has been espoused as a key component of nursing education for many decades. In the last 10 years the terms caring and connecting are commonly found associated with each other, and yet there is no clear definition of connecting. It is important to understand a phenomenon from the point of view of those who are experiencing it. Therefore, a study which asked nursing educators to tell stories of the times they had connected with students was undertaken. Ten nurse educators in the …

Genetic And Biochemical Characterization Of Drosophila Singed, A Homolog Of The Actin Bundling Protein Fascin, Kelly Cant

Yale Medicine Thesis Digital Library

Drosophila singed mutants were named for their gnarled bristle phenotype, however, severe alleles are also female sterile due to a defect in nurse cell cytoplasm transport. Recently, singed protein was shown to have 35% peptide identity with the actin bundling protein fascin. I present evidence that singed is a homolog of fascin. In vivo, singed is required for actin filament bundle formation in the cytoplasm of nurse cells during oogenesis and in the cellular extension that forms a bristle. In vitro, purified bacterially-expressed singed bundles actin filaments with the same 12 nm periodicity and stoichiometry reported for sea urchin fascin.While …

Removal Of Extracellular Chloride Suppresses Transmitter Release From Photoreceptor Terminals In The Mudpuppy Retina., Wallace B. Thoreson, R . F. Miller

Journal Articles: Ophthalmology

Removal of extracellular Cl- has been shown to suppress light-evoked voltage responses of ON bipolar and horizontal cells, but not photoreceptors or OFF bipolar cells, in the amphibian retina. A substantial amount of experimental evidence has demonstrated that the photoreceptor transmitter, L-glutamate, activates cation, not Cl-, channels in these cells. The mechanism for Cl-free effects was therefore reexamined in a superfused retinal slice preparation from the mudpuppy (Necturus maculosus) using whole-cell voltage and current clamp techniques. In a Cl-free medium, light-evoked currents were maintained in rod and cone photoreceptors but suppressed in horizontal, ON bipolar, and OFF bipolar cells. Changes …

Prefabrication Of A Secondary Tram Flap., Geoffrey G. Hallock Md

Department of Surgery

A secondary TRAM flap was prefabricated in a rat model using the rectus muscle. The right rectus muscle was elevated as an inferiorly pedicled muscle flap in one experimental group (n = 6) and as a superiorly pedicled muscle flap in a second group (n = 5) and then sandwiched between a silicone sheet and the abdominal skin. Two weeks later, the abdominal skin and attached rectus muscle were elevated over the silicone sheet as a secondary TRAM flap. The surviving skin paddle areas of these prefabricated TRAM flaps were compared with superiorly (n = 7) and inferiorly (n = …

Oochoristica Scelopori (Cestoda: Linstowiidae) In A Grassland Population Of The Bunch Grass Lizard, Sceloporus Scalaris (Phrynosomatidae), From Arizona, Stephen R. Goldberg, Charles R. Bursey, Chris T. Mcallister, Hobart M. Smith, Quynh A. Truong

Great Basin Naturalist

No abstract provided.

Effects Of Douglas-Fir Foliage Age Class On Western Spruce Budworm Oviposition Choice And Larval Performance, Kimberly A. Dodds, Karen M. Clancy, Kathryn J. Leyva, David Greenberg, Peter W. Price

Great Basin Naturalist

The western spruce budworm (Choristoneura occidentalis Freeman) prefers to feed on flushing buds and current-year needles of Douglas-fir (Pseudotsuga menziesii [Mirb.] Franco). Budworm larvae will not typically consume older age classes of needles unless all current-year foliage is depleted. We tested the following null hypotheses: (1) budworm larvae can feed on foliage with a wide range of qualities (i.e., current 1-, 2-, or 3-year-old needles) without measurable effects on fitness; and (2) budworm adults do not show any oviposition preference linked to the age of the foliage they fed on as larvae. We used both laboratory and field …

Selecting Wilderness Areas To Conserve Utah's Biological Diversity, Diane W. Davidson, William D. Newmark, Jack W. Sites Jr., Dennis K. Shiozawa, Eric A. Rickart, Kimball T. Harper, Robert B. Keiter

Great Basin Naturalist

Congress is currently evaluating the wilderness status of Bureau of Land Management (BLM) public lands in Utah. Wilderness areas play many important roles, and one critical role is the conservation of biological diversity. We propose that objectives for conserving biodiversity on BLM lands in Utah be to (1) ensure the long-term population viability of native animal and plant species, (2) maintain the critical ecological and evolutionary processes upon which these species depend, and (3) preserve the full range of communities, successional stages, and environmental gradients. To achieve these objectives, wilderness areas should be selected so as to protect large, contiguous …